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The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}}, "$insert": {"model_sequences": {"sequence": {"3528": {"dna_sequence": {"fmax": "4277383", "fmin": "4277059", "accession": "NC_000913", "strand": "-", "sequence": "TTACAGGCGGTGGCGATAATCGCTGGGAGTGCGATCAAACTGCCGACGGAAAACGCGGGAGAAGGTCTGCTGCGAGACATAACCCAGGTCCATTGCGATATCAAAAATCGGACGCTCGGTGGTGCGCAACTCAACGGCGGCCAGTAACAGGCGGCGTTGGCGAATGTAATCGCCAAGCGTCTGATGCGTCACCGTGCGGAACATTCGTTGCAAGTACCACTTTGAATAGCCTGATTTTTTTGCGACTACATCAATGTTAAGCGGCTGGTCAATATGCTCGTCAATCCATGCGATAAGATCCTGAATAATTTTCTGATGGGACAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. 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"ATGAATCAGGAAGTTAAAAACAAAATATTTTCAATCTTAAAAATTACGTTTGCTACAGCTTTATTTATTTTTGTAGCAATCACATTGTATCGGGAGTTATCTGGTATTAACTTTAAAGATACGTTGGTTGAATTTAGTAAGATTAACCGTATGTCCTTAGTGTTACTATTTATTGGTGGTGGGGCATCGCTTGTTATTCTATCAATGTATGATGTGATTTTATCTAGAGCTTTAAAAATGGATATATCCTTAGGCAAAGTTTTAAGAGTAAGTTATATCATCAATGCATTGAATGCGATTGTAGGTTTCGGTGGCTTTATTGGTGCAGGCGTTAGAGCAATGGTTTATAAAAACTATACGCATGATAAAAAGAAATTAGTTCACTTTATATCCTTAATACTTATTTCAATGTTGACAGGTTTAAGCTTATTATCATTGCTAATTGTATTCCATGTTTTCGATGCATCTTTAATCTTAGATAAGATTACATGGGTAAGATGGGTATTATATGTAGTGTCATTTTTCTTACCATTATTCATTATTTATTCAATGGTTAGACCACCCGATAAAAACAATCGTTTTGTAGGATTGTACTGCACTTTAGTGTCGTGTGTTGAATGGTTAGCAGCTGCAGTTGTATTATATTTCTGTGGTGTAATTGTTGACGCTCATGTATCATTCATGTCCTTTATTGCAATATTTATCATTGCTGCATTATCAGGTTTAGTCAGCTTTATTCCTGGTGGTTTCGGCGCTTTCGATTTAGTTGTATTACTAGGATTTAAAACTTTAGGTGTCCCTGAGGAAAAAGTATTATTAATGCTACTTCTATATCGTTTTGCGTACTATTTTGTACCGGTAATTATTGCATTAATTTTATCATCATTTGAATTTGGTACATCAGCTAAGAAGTACATTGAGGGATCTAAATACTTTATTCCTGCTAAAGATGTTACGTCATTTTTAATGTCTTATCAAAAGGATATTATTGCTAAAATTCCATCATTATCATTAGCAATTTTAGTATTCTTTACAAGTATGATCAACTTAACGATTGTTTACGATGCTTTATATGATGGAAATCACTTAACGTATTATATTCTATTGGCAATTCATACTAGTGCTTGTTTATTACTTTTACTGAATGTAGTTGGTATTTATAAGCAAAGTAGACGTGCCATTATCTTTGCTATGATTTCAATTTTATTAATCACAGTGGCGACATTCTTCACTTACGCTTCATATATTTTAATAACATGGTTAGCTATTATTTTTGTTCTGCTTATTGTAGCTTTCCGTAGAGCACGTAGGTTGAAACGCCCAGTAAGAATGAGAAATATAGTTGCAATGCTTTTATTCAGTTTATTTATTTTATATGTTAACCATATATTTATTGCTGGAACGTTATATGCATTAGATATTTATACGATTGAAATGCATACATCTGTATTGCGCTATTACTTCTGGCTTACGATTTTAATCATCGCTATCATCATAGGTATGATTGCATGGTTGTTTGATTATCAATTTAGCAAAGTACGTATTTCTTCTAAAATTGAAGATTGCGAGGAGATTATTAATCAGTACGGCGGTAATTATTTGAGTCACTTGATATATAGTGGTGACAAGCAGTTTTTCACTAATGAAAATAAAACAGCATTTTTAATGTATCGTTATAAAGCAAGTTCATTAGTGGTTCTTGGAGATCCGTTAGGTGATGAAAATGCCTTTGATGAATTGTTAGAAGCATTCTATAATTACGCTGAGTATTTAGGCTATGATGTTATATTCTATCAAGTTACAGATCAACACATGCCTTTATATCATAATTTCGGTAACCAATTTTTCAAATTAGGTGAAGAAGCAATTATTGATTTAACGCAATTTTCAACTTCAGGTAAAAAACGCCGTGGATTTAGAGCGACTTTAAATAAATTCGATGAACTTAATATTTCGTTCGAAATTATTGAACCACCGTTTTCAACTGAATTTATAAATGAACTTCAACATGTAAGTGATTTATGGCTAGATAATCGTCAGGAAATGCATTTCTCTGTTGGTGAATTTAATGAAGAATACTTATCTAAAGCGCCAATTGGTGTAATGCGAAATGAAGAAAATGAAGTAATTGCATTTTGTAGTTTAATGCCAACATACTTTAATGATGCCATTTCAGTCGATTTAATTAGATGGTTGCCAGAGTTAGATTTACCATTAATGGATGGTCTATACTTGCATATGTTACTTTGGAGTAAAGAACAAGGTTATACAAAATTTAATATGGGTATGGCAACGTTATCGAACGTTGGTCAATTGCATTATTCATATTTAAGAGAACGACTTGCAGGCCGTGTCTTTGAACATTTCAACGGTCTATATCGTTTCCAAGGATTACGTCGTTATAAATCTAAATATAATCCGAATTGGGAACCACGCTTTTTAGTTTATCGTAAAGATAATTCGCTTTGGGAATCACTTTCTAAAGTAATGCGTGTAATACGTCACAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"GI": "ADJ67256", "sequence": "MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGGGASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYTHDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFIIYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALSGLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGTSAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMINLTIVYDALYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYILITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYTIEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSHLIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVIFYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEIIEPPFSTEFINELQHVSDLWLDNRQEMHFSVGEFNEEYLSKAPIGVMRNEENEVIAFCSLMPTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSYLRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK"}}}}}, "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3613": "T345K", "3614": "T472K", "3615": "M347R", "3616": "L341S", "3617": "V351E", "3609": "I420N"}}}, "$insert": {"clinical": {"2212": "T345A", "2211": "T345I", "2210": "P314L", "2204": "F57S", "2205": "I418N", "3616": "L341S", "2207": "G61V", "2208": "S337L", "2206": "S295L", "3609": "I420N", "3617": "V351E", "3613": "T345K", "2209": "L826F", "3614": "T472K", "3615": "M347R"}}}}}}}, "431": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2132": "R77L", "2133": "V96E", "2130": "I49S", "2131": "A70T", "2852": "R94H", "2109": "G103S", "2108": "R77C", "2103": "R94S", "2102": "Y137H", "2107": "R73S", "2106": "R73C", "2105": "V45E", "2104": "L78M"}}}}}}}, "579": {"$update": {"ARO_category": {"$insert": {"40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}}}}, "627": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2024": "Q513L", "2025": "Q513P", "2026": "H526Y", "2034": "R687H", "2033": "V146F", "2032": "P564L", "2031": "T563P", "2030": "L533P", "2027": "R529C", "2028": "R529S", "2029": "S531F"}}}}}}}, "626": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-170"}}}}}}, "624": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2040": "V472I", "2041": "S456L"}}}}}}}, "335": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2827": "P587S", "2828": "D434H", "2829": "D434N"}}}}}}}, "336": {"$update": {"ARO_name": "tlrB conferring tylosin resistance", "model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-120"}}}}}}, "499": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "455": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1966": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2887": "Q52P"}}}}}}}, "259": {"$update": {"ARO_category": {"$insert": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}}}}, "1872": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-130"}}}}}}, "2196": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3143": "T83I", "3144": "H80R", "3145": "D87N"}}}}}}}, "178": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-180"}}}}}}, "2198": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3149": "M437I", "3150": "A473V"}}}}}}}, "1907": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "558": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-100"}}}}}}, "2201": {"$update": {"ARO_description": "PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence", "model_type": "absent protein homolog model", "ARO_category": {"36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}, "40439": {"category_aro_name": "gene conferring resistance via absence", "category_aro_cvterm_id": "40439", "category_aro_accession": "3003768", "category_aro_description": "Deletion of gene or gene product results in resistance. For example, deletion of a porin gene blocks drug from entering the cell."}}, "model_description": "A model to detect the absence of a protein that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences and a curated BLASTP cut-off.", "model_type_id": "40354"}}, "2202": {"$delete": ["model_param"]}, "851": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["2594", "2595", "2596", "2597", "2590", "2591", "2592", "2593", "2635", "2634", "2637", "2613", "2631", "2599", "2617", "2632", "2626", "2612", "2611", "2583", "2580", "2616", "2587", "2627", "2622", "2586", "2606", "2607", "2600", "2601", "2581", "2603", "2628", "2609", "2589", "2588", "2624", "2619", "2633", "2620", "2604", "2615", "2610", "2578", "2579", "2577", "2574", "2585", "2570", "2571", "2636"], "$insert": {"3427": "P54T", "3434": "G17D", "3435": "Y34S", "3425": "T47A", "3426": "A140S", "3424": "D12E"}}}, "$insert": {"clinical": {"2614": "N118T", "2605": "L85P", "2572": "I5S", "2598": "P69R", "2630": "T142M", "2573": "V7G", "2621": "H137P", "3434": "G17D", "3435": "Y34S", "2623": "C138Y", "2584": "Y41H", "2582": "A26G", "2602": "C72R", "2625": "V139L", "2629": "T142K", "2608": "K96N", "2618": "G132S", "2576": "Q10P", "2575": "Q10R", "3427": "P54T", "3426": "A140S", "3425": "T47A", "3424": "D12E"}}}}}}}, "1981": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-180"}}}}}}, "1731": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["638", "636"]}}}}}, "2083": {"$update": {"ARO_category": {"$insert": {"36631": {"category_aro_name": "gene involved in self resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}}}, "model_param": {"$update": {"snp": {"$update": {"param_value": {"3545": "K134R"}}, "$insert": {"clinical": {"3545": "K134R"}}}}}}, "$insert": {"model_sequences": {"sequence": {"3491": {"dna_sequence": {"fmax": "636235", "fmin": "633433", "accession": "AGAC01000007.1", "strand": "-", "sequence": "CTATTTTTTCTTAATTTGTTTAATTTTTTGCATTATTGTTTCAAGATCTATTTTTTCAATTTCTTGTATTTTCTGACTAACGCTTTCTTTTGTTGCTATATTTTTTTTATCTTTTTGGTTGTCATTAACGTTATTTGAAACATTTGGTAATTCAATATCTTCAGTAGATATTTGAAATAGTTCTTCTTGTTCTTCATTATTTAAATGTTGAATATCTTGATTATAGGATTTTTTAATCAAAGCATGTTCAGCGGTCAATTCAATATTTTTATCAATATATCCTTGATATTCTTGTCTTATTTTTTCTTGCTCTATTTCATCAACTTCAATTAATTCATTAATTTTTATTGGCGTAATAAAATACCCAGGGTTAGTAAATGAATAATCTAATTTAAGAAGTTTACTTTCCTTAGTCTTATCTTTTAATATAAATTTTCAATCATATTCTGCCAAATTACCATTATTATCAGTGTATAACATTTTTAAATTGCTCAATGTAACAGCAAGTGATTGAAGACCTAAAATATTATTTTTTAGTGGCGTAAACAACATTTTTGGAGTATTGCGTGTGGTTGATTCTAATTTGCTAGTATCCCAACATTTTATATAGCCACCTTGCGTTAAATAAATTATATTGTTGTATTTTGAAACTGTTATAAAACCACTTACTTGAAGTTGAGGATGTTTATATAAGTTTAAAAGAAGTCTAATGCCTCTTGCTTTCAAAGAAATTCCAACCTTTAGTTCGTTTTCCGAAACTAAATGATACATACCATTATTTAGTAAAATAAATAGCATTTTTTCATCATTAGAAATTTGAGCATCTATTAATTCATCATTATCATCTTTAAACGACATGCACGTTTTTGTTTTAAGAGAAGATTTATTTTCAAAATCTCTTAAATTAACTTTTTTGGCATATCCTAATTTTGACATTAAAATAAAGTTTGCATAATTATTGAATGACGTAATTTCTATAACTCTAATAATTTTTTCTGAGCTTTCTAGAGCTACTATTGATGAAATATGTTGGCCAAGATCTTTTCAATTGCAATCTTTAAACAAATGGCAATCAATAATAAAATAATTCCCTAAATTTGTAAAGAATAATATCTTTGATAATGAGTTTACTTTATCAAAATAGAAAACATTGTCTTCTTCTTTTAATTTGAACGTGCTTAATTCATTGCTAGTATAAACTTTTAAACTTATTTTTTTATAATATCCATCTTTGGTTATATATAAATAAAAATCTTCATTTTTTGTCAATAATTTATGATCAATTTCTTTATCGATTTTTTGATCTGAAATTTCCGTTAATCTTGGCTTTGAATATTGATTTTTTATTTCAAGCAATTGCTTTATTAAATATTGATTAAATTCTCATTTATCATTTAATAATTTATTGCAATTTTCAATTTGAATTTCAAGGTTTTTCTTTTCTTCTTGAAATTCAATTTGATCCATTCTTGAAAGCTTATACAATCTTAATTCAGCAATCGCTGTTGCTTGCAATTCACTAAATTTAAATTTATTCATCAATGCAAGGATAACACCTTTTTTTGAGTTATCGCTTTCTTTAATCAAATGTATAACTTCATCAGAAATTTCAGCTACTTTAATGAACCCTTCAACTATTTCAAGTCTTAATTTAAACTTCTTTAAATCATAATTAATACCATTTATATTAACTTCTTTTAAATGACTTAAATAAGCAATTAAAGCACTATAGAGATTTAGAATTACTGGACGGTTATTGTCAATTGCAACCATGTTATAACTATACGAGATACTTAGTTCGGTTTTATTCATTAAGTATGCAATTATTGCGTCAGCATTTGCACCGTCTTCTAATTGAATAAATATTGAAATTCCGTTTCTATCTGTTTGATCCAAAACTTCTTTAATACCAGAAATTTTTTTATCTATTGCAATTGCATCAATGTCGGCAACTAATTTTGATTTAACAACCCCAAAAGGAATTTCAATTATTTCAATGCCAATAATTTTCGATTCATCTTTTTTATCATAAACATAATGATATTTCGAAGAAATTGTAATTCTACCTTGCCCACTTGAAAGAGCTTTTTTTATTTCATTTATACCATTAATAATTGCTCCTGTTGGGAAATCCGGTCCTTTAACTATTTCACTTAATTCTTCAATTGATATTGTAGGATTTTTGATTAATGCAATTGTTGCATCAATAACTTCGCCTAGATTATGTGGTGGGATTTCTGTAGCAAAACCAGCAGCAATTCCTTTAGCACCGTTAACTAATAAATTAGGAAATAAGGCCGGCAAAACAATTGGTTCGTATTCAGAGTCATCAAAGTTTGGAGCCATTTTTACAACTTTTCTGTCTAAATCTTTCAACATCAGTTCACTAATTTTTTCAAGTCTTGATTCAGTGTAACGCATTGCAGCGGCAGGGTCATCATCAATTGAACCTTTATTACCATGCATTTCAATTAATGGGAAATTGCTTTTTCAATCTTGAGCCATTCTGACTAATGCTTCGTATATTGAACTATCTCCATGAGGGTGATAACGTCCGATAACATCCCCAACGATTCTAGCTGATTTTTTAAAAGGTTCGCTATTTTTTAAATGTAAATTTCACATTGAATATAAAATCCGACGTTGAACAGGTTTTAGTCCATCACGAGCATCAGGAATTGCTCTTTGTTGAATAATGTATTTTGAATAACGTCCGAATCTATCAGACATTATATCGGCCATATTTTTTTCAATAATGTTTTCAGTAACTTCTTGTATTTCTTCTTTTCTATCTTTTTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycoplasma hominis ATCC 23114", "NCBI_taxonomy_id": "347256", "NCBI_taxonomy_cvterm_id": "40300"}, "protein_sequence": {"GI": "AVGJ01000262.1", "sequence": "MKKDRKEEIQEVTENIIEKNMADIMSDRFGRYSKYIIQQRAIPDARDGLKPVQRRILYSMWNLHLKNSEPFKKSARIVGDVIGRYHPHGDSSIYEALVRMAQDWKSNFPLIEMHGNKGSIDDDPAAAMRYTESRLEKISELMLKDLDRKVVKMAPNFDDSEYEPIVLPALFPNLLVNGAKGIAAGFATEIPPHNLGEVIDATIALIKNPTISIEELSEIVKGPDFPTGAIINGINEIKKALSSGQGRITISSKYHYVYDKKDESKIIGIEIIEIPFGVVKSKLVADIDAIAIDKKISGIKEVLDQTDRNGISIFIQLEDGANADAIIAYLMNKTELSISYSYNMVAIDNNRPVILNLYSALIAYLSHLKEVNINGINYDLKKFKLRLEIVEGFIKVAEISDEVIHLIKESDNSKKGVILALMNKFKFSELQATAIAELRLYKLSRMDQIEFQEEKKNLEIQIENCNKLLNDKWEFNQYLIKQLLEIKNQYSKPRLTEISDQKIDKEIDHKLLTKNEDFYLYITKDGYYKKISLKVYTSNELSTFKLKEEDNVFYFDKVNSLSKILFFTNLGNYFIIDCHLFKDCNWKDLGQHISSIVALESSEKIIRVIEITSFNNYANFILMSKLGYAKKVNLRDFENKSSLKTKTCMSFKDDNDELIDAQISNDEKMLFILLNNGMYHLVSENELKVGISLKARGIRLLLNLYKHPQLQVSGFITVSKYNNIIYLTQGGYIKCWDTSKLESTTRNTPKMLFTPLKNNILGLQSLAVTLSNLKMLYTDNNGNLAEYDWKFILKDKTKESKLLKLDYSFTNPGYFITPIKINELIEVDEIEQEKIRQEYQGYIDKNIELTAEHALIKKSYNQDIQHLNNEEQEELFQISTEDIELPNVSNNVNDNQKDKKNIATKESVSQKIQEIEKIDLETIMQKIKQIKKK"}}}}}}, "1989": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2128": "Y114F", "2185": "M109I", "2867": "V165I"}}}}}}}, "159": {"$update": {"ARO_category": {"$insert": {"40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}}}}, "1699": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "734": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "2111": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2901": "A1355G"}}}}}}}, "1509": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "1036": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-100"}}}}}}, "2149": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2907": "T1482C", "3016": "T1389C", "3062": "C1480T"}}}}}}}, "2116": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3059": "C1194G"}}}}}}}, "1035": {"$update": {"ARO_category": {"$insert": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}}}}, "752": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1210": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-130"}}}}}}, "756": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"22": "W73C"}}}}}}}, "1608": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-100"}}}}}}, "465": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1219": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "786": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "462": {"$update": {"model_sequences": {"$update": {"sequence": {"3553": {"dna_sequence": {"fmax": "1279164", "fmin": "1278585", "accession": "NC_003923", "strand": "+", "sequence": "ATGAATATTCCGAACCAGATTACGGTTTTTAGAGTAGTGTTAATACCAGTTTTTATATTGTTTGCGTTAGTTGATTTTGGATTTGGCAATGTGTCATTTCTAGGAGGATATGAAATAAGAATTGAGTTATTAATCAGTGGTTTTATTTTTATATTGGCTTCCCTTAGCGATTTTGTTGATGGTTATTTAGCTAGAAAATGGAATTTAGTTACAAATATGGGGAAATTTTTGGATCCATTAGCGGATAAATTATTAGTTGCAAGTGCTTTAATTGTACTTGTGCAACTAGGACTAACAAATTCTGTAGTAGCAATCATTATTATTGCCAGAGAATTTGCCGTAACTGGTTTACGTTTACTACAAATTGAACAAGGATTCGTAAGTGCAGCTGGTCAATTAGGTAAAATTAAAACAGCAGTTACTATGGTAGCAATTACTTGGTTGTTATTAGGTGATCCATTGGCAACATTGATTGGTTTGTCATTAGGACAAATTTTATTATACATTGGCGTTATTTTTACTATCTTATCTGGTATTGAATACTTTTATAAAGGTAGAGATGTTTTTAAACAAAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"GI": "WP_001025093", "sequence": "MNIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIFILASLSDFVDGYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTNSVVAIIIIAREFAVTGLRLLQIEQGFVSAAGQLGKIKTAVTMVAITWLLLGDPLATLIGLSLGQILLYIGVIFTILSGIEYFYKGRDVFKQK"}}}}}, "model_param": {"$update": {"snp": {"$insert": {"experimental": {"2213": "A64V", "2214": "S177F", "2215": "K66R", "2229": "V59N"}}}}}}}, "2183": {"$delete": ["model_param"]}, "2182": {"$delete": ["model_param"]}, "2181": {"$delete": ["model_param"]}, "2180": {"$delete": ["model_param"]}, "2186": {"$delete": ["model_param"]}, "2185": {"$delete": ["model_param"]}, "2184": {"$delete": ["model_param"]}, "164": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-170"}}}}}}, "90": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2862": "Q468K", "2055": "A473T", "2054": "H481N", "2057": "L466S", "2056": "Q465R", "2083": "A477T"}}}}}}}, "97": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-130"}}}}}}, "1046": {"$update": {"ARO_category": {"$insert": {"40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}}}}, "1622": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "966": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "2113": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2899": "T1406A"}}}}}}}, "1626": {"$update": {"ARO_category": {"$insert": {"40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}}}}, "2215": {"$update": {"ARO_category": {"$insert": {"36631": {"category_aro_name": "gene involved in self resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}}}, "model_param": {"$update": {"snp": {"$insert": {"clinical": {"3166": "E91K", "3167": "S87W", "3165": "S87L"}}}}}}}, "2158": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2965": "R334C", "3019": "R234F", "2934": "T335A", "3030": "R231C", "3020": "R234S", "3044": "R231V"}}}}}}}, "2122": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2953": "A1355G"}}}}}}}, "1181": {"$update": {"ARO_category": {"$insert": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}}}}, "2109": {"$update": {"model_sequences": {"$update": {"sequence": {"3530": {"dna_sequence": {"fmax": "7267", "fmin": "5239", "accession": "NC_009525.1", "strand": "+", "sequence": "GTGGCTGCCCAGAAAAAGAAGGCCCAAGACGAATACGGCGCTGCGTCTATCACCATTCTCGAAGGGCTGGAGGCCGTCCGCAAACGTCCCGGCATGTACATTGGCTCGACCGGTGAGCGCGGTTTACACCATCTCATTTGGGAGGTGGTCGACAACGCGGTCGACGAGGCGATGGCCGGTTATGCAACCACAGTGAACGTAGTGCTGCTTGAGGATGGCGGTGTCGAGGTCGCCGACGACGGCCGCGGCATTCCGGTCGCCACCCACGCCTCCGGCATACCGACCGTCGACGTGGTGATGACACAACTACATGCCGGCGGCAAGTTCGACTCGGACGCGTATGCGATATCTGGTGGTCTGCACGGCGTCGGCGTGTCGGTGGTTAACGCGCTATCCACCCGGCTCGAAGTCGAGATCAAGCGCGACGGGTACGAGTGGTCTCAGGTTTATGAGAAGTCGGAACCCCTGGGCCTCAAGCAAGGGGCGCCGACCAAGAAGACGGGGTCAACGGTGCGGTTCTGGGCCGACCCCGCTGTTTTCGAAACCACGGAATACGACTTCGAAACCGTCGCCCGCCGGCTGCAAGAGATGGCGTTCCTCAACAAGGGGCTGACCATCAACCTGACCGACGAGAGGGTGACCCAAGACGAGGTCGTCGACGAAGTGGTCAGCGACGTCGCCGAGGCGCCGAAGTCGGCAAGTGAACGCGCAGCCGAATCCACTGCACCGCACAAAGTTAAGAGCCGCACCTTTCACTATCCGGGTGGCCTGGTGGACTTCGTGAAACACATCAACCGCACCAAGAACGCGATTCATAGCAGCATCGTGGACTTTTCCGGCAAGGGCACCGGGCACGAGGTGGAGATCGCGATGCAATGGAACGCCGGGTATTCGGAGTCGGTGCACACCTTCGCCAACACCATCAACACCCACGAGGGCGGCACCCACGAAGAGGGCTTCCGCAGCGCGCTGACGTCGGTGGTGAACAAGTACGCCAAGGACCGCAAGCTACTGAAGGACAAGGACCCCAACCTCACCGGTGACGATATCCGGGAAGGCCTGGCCGCTGTGATCTCGGTGAAGGTCAGCGAACCGCAGTTCGAGGGCCAGACCAAGACCAAGTTGGGCAACACCGAGGTCAAATCGTTTGTGCAGAAGGTCTGTAACGAACAGCTGACCCACTGGTTTGAAGCCAACCCCACCGACGCGAAAGTCGTTGTGAACAAGGCTGTGTCCTCGGCGCAAGCCCGTATCGCGGCACGTAAGGCACGAGAGTTGGTGCGGCGTAAGAGCGCCACCGACATCGGTGGATTGCCCGGCAAGCTGGCCGATTGCCGTTCCACGGATCCGCGCAAGTCCGAACTGTATGTCGTAGAAGGTGACTCGGCCGGCGGTTCTGCAAAAAGCGGTCGCGATTCGATGTTCCAGGCGATACTTCCGCTGCGCGGCAAGATCATCAATGTGGAGAAAGCGCGCATCGACCGGGTGCTAAAGAACACCGAAGTTCAGGCGATCATCACGGCGCTGGGCACCGGGATCCACGACGAGTTCGATATCGGCAAGCTGCGCTACCACAAGATCGTGCTGATGGCCGACGCCGATGTTGACGGCCAACATATTTCCACGCTGTTGTTGACGTTGTTGTTCCGGTTCATGCGGCCGCTCATCGAGAACGGGCATGTGTTTTTGGCACAACCGCCGCTGTACAAACTCAAGTGGCAGCGCAGTGACCCGGAATTCGCATACTCCGACCGCGAGCGCGACGGTCTGCTGGAGGCGGGGCTGAAGGCCGGGAAGAAGATCAACAAGGAAGACGGCATTCAGCGGTACAAGGGTCTAGGTGAAATGGACGCTAAGGAGTTGTGGGAGACCACCATGGATCCCTCGGTTCGTGTGTTGCGTCAAGTGACGCTGGACGACGCCGCCGCCGCCGACGAGTTGTTCTCCATCCTGATGGGCGAGGACGTCGACGCGCGGCGCAGCTTTATCACCCGCAACGCCAAGGATGTTCGGTTCCTGGATGTCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Ra", "NCBI_taxonomy_id": "419947", "NCBI_taxonomy_cvterm_id": "40415"}, "protein_sequence": {"GI": "CAA55486.1", "sequence": "MGKNEARRSALAPDHGTVVCDPLRRLNRMHATPEESIRIVAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV"}}}}}, "model_param": {"$insert": {"snp": {"param_type": "single resistance variant", "param_value": {"3462": "N538D", "3461": "D500H", "3460": "V340L"}, "clinical": {"3462": "N538D", "3461": "D500H", "3460": "V340L"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}}}, "2108": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3055": "G258A", "2952": "G276A"}}}}}}}, "1748": {"$update": {"ARO_category": {"$insert": {"40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}}}}, "2054": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["364", "365"]}}}, "model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-130"}}}}}}, "1976": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-100"}}}}}}, "111": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2158": "R136H", "2159": "R136S", "2156": "R136L", "2157": "R136C", "2161": "R136I", "2160": "R136G", "2162": "R136E"}}}}}}}, "2100": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2981": "A1355G"}}}}}}}, "1510": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1108": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"39": "A180T", "2203": "E192G", "44": "T120A", "2252": "H264Q"}}}}}}}, "2104": {"$update": {"ARO_category": {"$insert": {"36631": {"category_aro_name": "gene involved in self resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}}}, "model_param": {"$update": {"snp": {"$insert": {"clinical": {"2946": "S83L", "2940": "S83W", "3051": "S84P"}}}}}}, "$insert": {"model_sequences": {"sequence": {"3529": {"dna_sequence": {"fmax": "533999", "fmin": "531446", "accession": "NC_002162.1", "strand": "+", "sequence": "ATGAGTGTAAATCATCAAAAAATTATTAATACACCTTTAGACAACATTGTTGGTGAAAGTTATGCAAAATATGCAAAATACATTATTCAAGATCGTGCTTTACCTGATATTCGTGATGGTTTAAAACCTGTTCAACGACGAATTTTATACGCAATGAGTGAATTAGGAATCTTTTATGATAAACCTTATAAAAAATCTGCACGTACAGTAGGAGAAGTAATTGGTAAATATCATCCACATGGAGATTCATCAATTTATGAAGCAATGGTGAGAATGAGTCAAGATTGAAAAAATAATCTATGTTTATTAGATATGCATGGTAATAAAGGTTCAATTGATGGTGATAATGCTGCTGCAATGCGTTATACAGAAGCTCGATTATCAAAAATTGCTAGTGTAATGTTAGCCAACTTAAAAAAAGATGTTGTTAAATTTAGTCCAAACTTTGATGATAGTGAAAAAGAGCCATCAATTTTACCATCTCTTTTTCCTAATTTGTTAATCAATGGAGCAACAGGAATTGCTTCTGGTTATGCAACAAATATTCCTCCTCATAACCCTAATGAAGTTTTTGATGCTTTAATTTATCGTATTGATCATCCAGATTGTAGTGTAGAAAAACTAATTGAAATCTGTCCTGCGCCAGATTTTCCCACAGGTGGGGAAATCCACGATTTAAATGGATGTGCTAATGCTCACAAAACTGGTGAAGGTAAATTTATAATTCGTGCTTGCATTGATTTTAAAATCAATGATAATAAGATTAATCAAATTATTATTAGTTCAATCCCTTATGAAACAAACAAGGCTTTAATCATTAAAGAAATTGAAGATATTATTTATAATAAAGAAGTTGCTGGATTAATCGAAGTTCGTGATGAATCTGATGCTAAGGGAATTAGTATAATTATTGATACTAAAAAAGATATTAATTTAGAAAATGTTAAAAACTATTTATATAAAAAAACCAACTTGGAAATCAGCTATAATACAAAATTTATTGCAATTGTTCACCGAACTCCTACACTTGTAAATCTATCTACATATTTAGATGCTCAAATTAATCATAGTTTAGATGTAATTAATAAAGTCGATTTATATGATCTAAACAAAATTTTGTTACGTATTGAAATTGTTGAAGGCTTAATTAAATGCGTTGATTTAATTGATGAAATTATTAAAATTATTCGTGCTAGTGAATCGCGTCAAGATGCAAAAAATACTTTAATTCAAGTTTTTAATTTTACAAATAATCAAGCTGAAGCGATTATTATGATGCGTTTACATAATTTGACACGTACTGATATATTTGATTTAAAAAATGAATGACAAACGCTACAAGACGAAGCTAAAACGCTACAAGAACGAATAAATTCACTTCAAGTTCGCAAAAATTATTTAAAACAAAAAATGATTGAATTTAAAAAAACTTTTGGTTTTGAACGCAAAACAAAATTATTTGATGAATTAGTAAAAGTTGAAATAAACGAAGATCAAATGATCGAAAAACAAAATTTGAATTTAGTAATAAGTCGTGATGGATACATTAAAACTGTTTCTAAAAAGTCATTTGAGTCATCTAAATATGATGAATTAGGATTAAAAACTAATGATATTCTTTTTTATCATAATATCATTAATTCTCATGATAAAATCCTAATCATTACATCAAAAGCTAAATTAATTAATTTAGTTGCTCATAAAATCACTTCTATGCGGTGAAAAGATGTTGGTGAACACTTAAATAATTATGTGAAATTTGATGCTAATGAAAAAGTTATAGCTGTTTATATATGGAACGAACAATTTAAAATTGATGAATATCAATTAGTTTTGGCTTCTAGATTAAATCTAATTAAAAGAATTGAATTAAGCGAGTTGGATATAAATAAAAATAGTAAACAAATTAGCATTATGAAATTAAATGATAATGATAATTTAATCAGTGCTAATTTAATCAAAAAAGGTCATAATCAATTTATTATTGCAATTTCTAAATTAGGATTAGCCCTGCTATTTTTAGTTCATGAAATTAATTGCTTAAATCGTTTAGCTAAAGGAATTAAAATTATGAAATTAAAACCAAATGATGAGGTTAGTGCTATTTTAATTACTCCTAATAATGGTTATAATGTTCAACTTTTTTTAGAACGGGGAAGTAAGTGTTTTAATATTAGTGAATTAAAATTATCAAAACGTGCGGCCACACCAACAAATTTATATCCAATAACAAAAAAAGTGCAAAATGTTTTAGCAGCTTTTTTAGTTGCTCATGAAAATGTTTTTTATCTTTTAGATCAACAACAAAAAATAAATCCATATTACTTATCAAACCCCAAACCAACAAAACTAGATACTAAAATTAGTATCTATGAAAACGATCAAATGATCACTGATGTAGTTAAAGATTGCTTTTTAAGTGATGAAGCAATTAGTGATTTTAAAAAAATTAATATGTACGCAAATGAATTTGATAATGAAATGCTAAAAATTAATAAAAATCACGATGATTCACAATTAGAATTAATTGATGAAGAGGAAGAAAAAAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Ureaplasma parvum", "NCBI_taxonomy_id": "134821", "NCBI_taxonomy_cvterm_id": "40416"}, "protein_sequence": {"GI": "WP_010891786.1", "sequence": "MSVNHQKIINTPLDNIVGESYAKYAKYIIQDRALPDIRDGLKPVQRRILYAMSELGIFYDKPYKKSARTVGEVIGKYHPHGDSSIYEAMVRMSQDWKNNLCLLDMHGNKGSIDGDNAAAMRYTEARLSKIASVMLANLKKDVVKFSPNFDDSEKEPSILPSLFPNLLINGATGIASGYATNIPPHNPNEVFDALIYRIDHPDCSVEKLIEICPAPDFPTGGEIHDLNGCANAHKTGEGKFIIRACIDFKINDNKINQIIISSIPYETNKALIIKEIEDIIYNKEVAGLIEVRDESDAKGISIIIDTKKDINLENVKNYLYKKTNLEISYNTKFIAIVHRTPTLVNLSTYLDAQINHSLDVINKVDLYDLNKILLRIEIVEGLIKCVDLIDEIIKIIRASESRQDAKNTLIQVFNFTNNQAEAIIMMRLHNLTRTDIFDLKNEWQTLQDEAKTLQERINSLQVRKNYLKQKMIEFKKTFGFERKTKLFDELVKVEINEDQMIEKQNLNLVISRDGYIKTVSKKSFESSKYDELGLKTNDILFYHNIINSHDKILIITSKAKLINLVAHKITSMRWKDVGEHLNNYVKFDANEKVIAVYIWNEQFKIDEYQLVLASRLNLIKRIELSELDINKNSKQISIMKLNDNDNLISANLIKKGHNQFIIAISKLGLALLFLVHEINCLNRLAKGIKIMKLKPNDEVSAILITPNNGYNVQLFLERGSKCFNISELKLSKRAATPTNLYPITKKVQNVLAAFLVAHENVFYLLDQQQKINPYYLSNPKPTKLDTKISIYENDQMITDVVKDCFLSDEAISDFKKINMYANEFDNEMLKINKNHDDSQLELIDEEEEKK"}}}}}}, "2106": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2929": "A1391G", "2970": "T1389A"}}}}}}}, "606": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-160"}}}}}}, "744": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1161": {"$update": {"ARO_category": {"$insert": {"40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}}}}, "1033": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "748": {"$update": {"ARO_category": {"$insert": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}}}}, "158": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-90"}}}}}}, "1203": {"$update": {"ARO_description": "Mutations in the Mycobacterium tuberculosis ndh gene that results in increased resistance to isoniazid.", "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3646": "L50V", "3644": "G313R", "3643": "T110A", "3642": "R268H", "3641": "A300P"}}}, "$insert": {"clinical": {"2310": "V18A", "2402": "R13C", "3646": "L50V", "3644": "G313R", "3643": "T110A", "3642": "R268H", "3641": "A300P"}}}}}}}, "36": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2127": "A91T"}}}}}}}, "1899": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-130"}}}}}}, "1894": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2136": "R46P", "2137": "M84I", "2864": "E160D", "2138": "Y59H", "2139": "T18P", "2155": "G25A"}}}}}}}, "722": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "2136": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3068": "T1406A", "2904": "A1408G"}}}}}}}, "2137": {"$update": {"model_sequences": {"$update": {"sequence": {"3531": {"dna_sequence": {"fmax": "2945", "fmin": "1760", "accession": "AH002539.2", "strand": "+", "sequence": "GTGTCTAAAGAAAAATTTGAACGTACAAAACCGCACGTTAACGTTGGTACTATCGGCCACGTTGACCACGGTAAAACTACTCTGACCGCTGCAATCACCACCGTACTGGCTAAAACCTACGGCGGTGCTGCTCGTGCATTCGACCAGATCGATAACGCGCCGGAAGAAAAAGCTCGTGGTATCACCATCAACACTTCTCACGTTGAATACGACACCCCGACCCGTCACTACGCACACGTAGACTGCCCGGGGCACGCCGACTATGTTAAAAACATGATCACCGGTGCTGCTCAGATGGACGGCGCGATCCTGGTAGTTGCTGCGACTGACGGCCCGATGCCGCAGACTCGTGAGCACATCCTGCTGGGTCGTCAGGTAGGCGTTCCGTACATCATCGTGTTCCTGAACAAATGCGACATGGTTGATGACGAAGAGCTGCTGGAACTGGTTGAAATGGAAGTTCGTGAACTTCTGTCTCAGTACGACTTCCCGGGCGACGACACTCCGATCGTTCGTGGTTCTGCTCTGAAAGCGCTGGAAGGCGACGCAGAGTGGGAAGCGAAAATCCTGGAACTGGCTGGCTTCCTGGATTCTTATATTCCGGAACCAGAGCGTGCGATTGACAAGCCGTTCCTGCTGCCGATCGAAGACGTATTCTCCATCTCCGGTCGTGGTACCGTTGTTACCGGTCGTGTAGAACGCGGTATCATCAAAGTTGGTGAAGAAGTTGAAATCGTTGGTATCAAAGAGACTCAGAAGTCTACCTGTACTGGCGTTGAAATGTTCCGCAAACTGCTGGACGAAGGCCGTGCTGGTGAGAACGTAGGTGTTCTGCTGCGTGGTATCAAACGTGAAGAAATCGAACGTGGTCAGGTACTGGCTAAGCCGGGCACCATCAAGCCGCACACCAAGTTCGAATCTGAAGTGTACATTCTGTCCAAAGATGAAGGCGGCCGTCATACTCCGTTCTTCAAAGGCTACCGTCCGCAGTTCTACTTCCGTACTACTGACGTGACTGGTACCATCGAACTGCCGGAAGGCGTAGAGATGGTAATGCCGGGCGACAACATCAAAATGGTTGTTACCCTGATCCACCCGATCGCGATGGACGACGGTCTGCGTTTCGCAATCCGTGAAGGCGGCCGTACCGTTGGCGCGGGCGTTGTTGCTAAAGTTCTGGGCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"GI": "AAA50993.1", "sequence": "MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG"}}}}}, "model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["2903", "2906", "2963", "2895", "2987", "2994", "2905", "3065", "3041", "3009", "2960"], "$insert": {"3312": "E379K", "3311": "Q125E", "3308": "L121Q", "3307": "Y161N", "3306": "Y161D", "3310": "A376S", "3313": "Y161C", "3305": "A376V", "3302": "G317D", "3303": "Q125R"}}}, "$insert": {"clinical": {"2947": "Q125K"}, "experimental": {"3305": "A376V", "3306": "Y161D", "3308": "L121Q", "3307": "Y161N", "3311": "Q125E", "3310": "A376S", "3313": "Y161C", "3312": "E379K", "3302": "G317D", "3303": "Q125R"}}}}}}}, "1817": {"$update": {"ARO_category": {"$insert": {"40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}}}}, "2132": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3026": "C1402T", "2923": "C1402A", "3014": "A1401G", "3040": "G1484T"}}}}}}}, "1055": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2226": "D476N"}}}}}}}, "1240": {"$update": {"ARO_description": "Bacillus Cluster A mph are chromosomally-encoded macrolide phosphotransferases that inactivate 14- and 15-membered macrolides such as erythromycin, clarithromycin, azithromycin.", "ARO_name": "Bacillus Cluster A intrinsic mph"}}, "1617": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "2224": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3176": "Q142X"}}}}}}}, "2223": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3173": "V44A", "3175": "Q10Z", "3174": "G46S", "3168": "G195E"}}}}}}}, "1197": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-70"}}, "snp": {"$update": {"param_value": {"$delete": ["2659", "2658", "2652", "2657", "2656", "2655", "2654", "2660"]}}, "$insert": {"clinical": {"2653": "K43R", "2651": "T40I", "2045": "K88Q", "2661": "K88R"}}}}}}}, "2139": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1696": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"experimental": {"2174": "E466D"}}}}}}}, "1298": {"$update": {"ARO_category": {"$insert": {"40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}}, "model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1441": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2085": "G133D"}}}}}}}, "1561": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "1635": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1754": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-170"}}}}}}, "1566": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-130"}}}}}}, "320": {"$update": {"ARO_category": {"$insert": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}}}}, "1176": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3239": "R463L", "3236": "P131R", "3237": "N194Y", "3243": "V68G", "3242": "P131Q", "3238": "W91R", "3240": "L101P", "3247": "S315I", "3246": "M126I", "3245": "S315N", "3244": "A234G", "2284": "S315T", "3241": "R128Q"}}}}}}}, "1175": {"$update": {"model_sequences": {"$update": {"sequence": {"3498": {"dna_sequence": {"fmax": "1010292", "fmin": "1008840", "accession": "JPPA01000001.1", "strand": "-", "sequence": "TTATAGGATTGGAGAAAATAATCGAGAAATTTGTTGCTTGAATAATAGCCAGTTAGACATTTCCTTGACTGTTTCAGTTGTCATGGATGAACAATGTGTCTCATCTTCTTTGAACTGAGTAGCAAGTTCTTCTAAAAACTCAGGATCGTAAATGACAGCACTTGTTTCAAAATTCAATCGGTAGCTACGAATATCTTGATTTGCTGAACCTACCATGCAGATTTCATCATCCATTATCAATGTTTTTGCATGGAGGAAGCCGTTCTCATAGACAAGGATTTGTACATTTTCCTTGATCAGCTGCCGAGCATAATATTGTGTTGCTCGATAAATAAAAGGATGATCCGGTTTGTTGGGAATCATGATTTTCACATCTACACCAGAGGCAGTTGCGATTTTTAAAGCAGCAATGACACTTTCATCAGGAACAAGGTAAGGTGTCTGTATCCAAACACGTTTTTTAGCAGAAGTAATCAATTTGATAAATGAAAGCTTGATTTGTTCCCTTTCGTTATTCGGTCCGCTTGAAACAAGCTGGATGGATGTATCAGCAAGCTTAGATTCATCTCGATCTGCTTTTTTAAAGAAATAATTCAAATGATAGCCGACCTTTTTTTCTTCAGGTACCGAGACGTTCCAGTCTGTTAAGAAGCGAAGCTGGAGCAAAGAAGAAGCGGCACCGAAAATCCGTATATGCGTATCGCGCCAATAGCCGAATTTTTTTGTTGTATTTACATATTGATTGGCAATATTGAAACCACCGGTATAACTAATCTTTCCATCGATCACAACGATTTTTCGGTGATCATGGTAATTCAATCGGAAACGAAGTAATGCCCTTTGTGAGGTAACAAATGTATGGACATGTCCACCATTTTTGATTAGACGATTGAAATCTTTTGCTTTTGTGCCATGAGAGCCAAATGCATCATATAATATTCGAACTTCCACGCCTTCTGCGGCTTTTTCTTCTAAAACATGTAAGACTTGCTGGCCGATATTATCTGTCACAAATGCGTAATATTCGATATGGATCGAATGTTTGGCTTTTTTTAGATCTTGAAGCAGTGAATCCAATTTCTCTTGTCCGTCTGTGAGAAGAGTGACAGAATTCATTCTTGTCAGCGGCATACGATTTAATGAAGAGAAGAAGTCAACAAATTGCTGTTTGTCTTTATCGCCCATGTCAGGATCGTAATGTTCAATGGTATCTCCTCTAAAAGACTGAAAGTTTTCTAATTCTTTCAAGTCACTTTGTCGGAGATAGAATTTTTTCTTATCCGTTAATCCACGTCCGAAAAATAAATATAATACAAAGCCCACCCCAGGAAGGGCAAATAATACTAAGAGCCATGCCCAAATGGCTGCTACATCTCGGGGTTTGATCAAAATAGCCACCAAAGCAATAAGTGCATTTAATAGATAAAGGGCGGTTATAATACTAGATACCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"GI": "AVIW01000092.1", "sequence": "MVSSIITALYLLNALIALVAILIKPRDVAAIWAWLLVLFALPGVGFVLYLFFGRGLTDKKKFYLRQSDLKELENFQSFRGDTIEHYDPDMGDKDKQQFVDFFSSLNRMPLTRMNSVTLLTDGQEKLDSLLQDLKKAKHSIHIEYYAFVTDNIGQQVLHVLEEKAAEGVEVRILYDAFGSHGTKAKDFNRLIKNGGHVHTFVTSQRALLRFRLNYHDHRKIVVIDGKISYTGGFNIANQYVNTTKKFGYWRDTHIRIFGAASSLLQLRFLTDWNVSVPEEKKVGYHLNYFFKKADRDESKLADTSIQLVSSGPNNEREQIKLSFIKLITSAKKRVWIQTPYLVPDESVIAALKIATASGVDVKIMIPNKPDHPFIYRATQYYARQLIKENVQILVYENGFLHAKTLIMDDEICMVGSANQDIRSYRLNFETSAVIYDPEFLEELATQFKEDETHCSSMTTETVKEMSNWLLFKQQISRLFSPIL"}}}}}, "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3574": "N13I", "3584": "A20D", "3585": "R267H", "3586": "D27N", "3578": "N13T"}}}, "$insert": {"clinical": {"3584": "A20D", "3585": "R267H", "3586": "D27N", "3574": "N13I", "2073": "R218Q", "2072": "H215R", "2074": "G178T", "2075": "K59T", "3578": "N13T"}}}}}}}, "89": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-130"}}}}}}, "1474": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2760": "I72N", "2763": "R83C", "2762": "L75R", "2761": "L75P", "2889": "I46N", "2891": "T69I", "2890": "L57R", "2825": "R91C", "2826": "R91H", "2888": "L45P"}}}}}}}, "1198": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-100"}}}}}}, "948": {"$update": {"ARO_category": {"$insert": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}}}}, "1340": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-100"}}}}}}, "1710": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["2065"]}}}, "model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["2167", "2170", "2171", "2168", "2166"]}}, "$insert": {"clinical": {"2165": "D464N", "2172": "E504V", "2169": "N502D"}}}}}}}, "1647": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-170"}}}}}}, "489": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3683": "G164C", "3682": "L49F", "3681": "L79F", "3678": "N52T", "3679": "G117E", "3672": "W45S", "3673": "P84L", "3670": "A183T", "3676": "G30R", "3675": "H48Y"}}}, "$insert": {"clinical": {"3678": "N52T", "3679": "G117E", "3672": "W45S", "3673": "P84L", "3670": "A183T", "3676": "G30R", "3675": "H48Y", "3235": "P75S", "2666": "D67H", "2667": "S70R", "2664": "R47Q", "2665": "I55S", "2662": "L16R", "2663": "W45C", "2668": "G71V", "3683": "G164C", "3682": "L49F", "3681": "L79F", "2671": "A134E", "2670": "Q127P", "2673": "W148R", "2672": "A138E", "2675": "V188G", "2674": "A183E", "2676": "A200E"}}}}}}}, "487": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-120"}}}}}}, "1354": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3583": "G5S"}}}, "$insert": {"clinical": {"3583": "G5S", "2396": "A201T", "2397": "G321S", "2395": "D4N", "2400": "D833A", "2401": "P913S", "2398": "G350D", "2399": "A462V"}}}}}}}, "1671": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2234": "E52K"}}}}}}}, "2102": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2936": "T1482C", "2954": "T1389C", "3037": "C1480T"}}}}}}}, "2239": {"$update": {"ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}}, "$insert": {"model_param": {"blastp_evalue": {"param_value": "1e-160", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}, "1595": {"$update": {"ARO_category": {"$insert": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}}}}, "2088": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3056": "G504C", "2978": "C506T", "2927": "C502T", "2948": "A503C"}}}}}}}, "_timestamp": "2016-06-06T21:07:56+00:00", "2124": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"3422": "G261E"}}, "$insert": {"clinical": {"3422": "G261E"}}}}}}}, "2127": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3012": "A1401G"}}}}}}}, "2126": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2918": "C1376T", "2920": "G1458T", "3049": "A1375G", "2926": "T1373A"}}}}}}}, "2129": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2910": "C1192A", "2919": "G1064A", "3023": "G1064T", "3070": "C1192G", "2959": "G1064C", "3064": "C1066T", "3046": "C1192T"}}}}}}}, "2128": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2983": "C1376T", "3005": "T1373A", "2958": "A1375G", "3002": "G1458T"}}}}}}}, "2080": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2933": "C1192T"}}}}}}}, "2131": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2911": "A1401G", "2989": "C513T", "3039": "C526T", "2938": "C517T", "3067": "A514T", "2949": "G427C", "3057": "C492T", "3054": "A906G", "3052": "A514C"}}}}}}}, "2086": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"3071": "G1053A", "2956": "C1054T", "2900": "A964G", "2988": "A1055G"}}}}}}}, "943": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-50"}}}}}}, "1607": {"$update": {"ARO_category": {"$insert": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}}}}, "2085": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2925": "G1068A"}}}}}}}, "1360": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"3430": "T214A", "3431": "T214I", "3429": "R184Q", "3428": "G124S"}}, "$insert": {"experimental": {"3430": "T214A", "3431": "T214I", "3429": "R184Q", "3428": "G124S"}}}}}}}, "350": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-60"}}}}}}, "1689": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "2105": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2896": "A1375G"}}}}}}}, "559": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-130"}}}}}}, "953": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"21": "I144T", "721": "L39F"}}}}}}}, "1368": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-100"}}}}}}, "1574": {"$update": {"model_param": {"$update": {"snp": {"$insert": {"clinical": {"2288": "I95P", "2289": "I194T", "2709": "I16T", "2224": "S94A", "2222": "I47T", "2223": "V78A", "2220": "I21V", "2221": "I21T"}}}}}}}}, "$delete": ["2095", "2134", "2135", "2130", "859", "2118", "2119", "2156", "2150", "2151", "2153", "2110", "2112", "2247", "2114", "2115", "2075", "2117", "651", "2187", "2079", "2189", "2188", "2071", "2121", "2120", "2123", "2089", "2125", "2082", "2081", "2159", "2168", "2103", "2101", "2166", "2064", "2067"], "$insert": {"2269": {"model_id": "2269", "ARO_accession": "3003756", "model_param": {"snp": {"param_type": "single resistance variant", "param_value": {"3489": "G192D", "3488": "E165A", "3483": "R107H", "3482": "G166D", "3485": "G192A", "3484": "Q44L", "3487": "W138C", "3486": "V93G"}, "clinical": {"3489": "G192D", "3488": "E165A", "3483": "R107H", "3482": "G166D", "3485": "G192A", "3484": "Q44L", "3487": "W138C", "3486": "V93G"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "nfsB encodes the minor oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA, while the increased resistance associated with second step mutants is a consequence of nfsB mutation.", "model_sequences": {"sequence": {"3522": {"dna_sequence": {"fmax": "605424", "fmin": "604770", "accession": "NC_000913.3", "strand": "-", "sequence": "TTACACTTCGGTTAAGGTGATGTTTTGCGGCAGACGAGATTTCGGCAGCGTAGCGTTAAAATCTTCAACGCTGTGATGACCTACCGGAACAACCACCAGACTGGTGTAGCCTTTCTCTTTCAGACCAAATTCTGCATCGAGGATGGCGGCGTCAAAACCTTCGATGGGTACCGCGTCCAGACCCAGAGCCGCCACGCCGAGCAGGAAGTTACCGACGTTGAGATAAACCTGTTTTGCCATCCACTCTGCATCATCATGCAGATCTTTACGGTGCATATCAGCGAAGAACTTGCGACCTTTATCGTTCGCGGCTTTCGCTTCCGGCGTGGCAAAGCGGCCATCGGCATCTTCCTGGTCAACAACCAGCTTCAGCCAGACATCGTCCATCGCGGTTTTTGCACAGAACACCACGACGTGCGAGGCATCAAGCATTTTACGCTCGTTGAACACGTAATTACCGGCAGCGGATTTGGCAACACGCGCTTTACCTTCTTCCGTGCTGGCAACAATAAAATGCCACGGCTGGGAGTTGGTGCTGGATGGGCTGTATTGCAGTAGCGTTTTGATCTGCTCGGCCTGTTCCGGGGTAAGTTTTTTGCTGGCATCAAATGCCTTAGTGGAATGACGCTTTAAGGCGACAGAAATGATATCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_415110.1", "sequence": "MDIISVALKRHSTKAFDASKKLTPEQAEQIKTLLQYSPSSTNSQPWHFIVASTEEGKARVAKSAAGNYVFNERKMLDASHVVVFCAKTAMDDVWLKLVVDQEDADGRFATPEAKAANDKGRKFFADMHRKDLHDDAEWMAKQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDAEFGLKEKGYTSLVVVPVGHHSVEDFNATLPKSRLPQNITLTEV"}}}}, "ARO_category": {"40420": {"category_aro_name": "nitrofuratoin resistance gene", "category_aro_cvterm_id": "40420", "category_aro_accession": "3003763", "category_aro_description": "Genetic determinants which confer resistance to nitrofuratoin."}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "Escherichia coli nfsB mutations conferring resistance to nitrofurantoin", "model_type": "multiple gene mutations model", "model_description": "A model to detect specific mutation(s) in different genes that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences, a curated BLASTP cut-off, and mapped mutations in each gene.", "ARO_id": "40413", "model_name": "Escherichia coli nfsB mutations conferring resistance to nitrofurantoin", "model_type_id": "40329"}, "2248": {"model_id": "2248", "ARO_accession": "3003731", "model_param": {"blastp_evalue": {"param_value": "1e-140", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "A specific fusidic acid resistance gene conferring intrinsic resistance in the bacteria Staphylococcus saprophyticus.", "model_sequences": {"sequence": {"3506": {"dna_sequence": {"fmax": "2257187", "fmin": "2256545", "accession": "NZ_CP014057", "strand": "+", "sequence": "ATGGAAAAACAACTTTACCCTTATCAATTTAATTATATAAAAGAACGCGTTGCACATTTAGTCAATGCTTATAATTCGGTCAACGATCCCAATACAATCGCTTCAATCAAAGATATCACACGCGATGAAATACTCAATACATTTAACTCGAGAGACACTACAATTCGTTCAAATGTTGAAAAGCTCATGAATGTACAACTAACTAAAGAACAAGCTCAAAAAATTTTAACGACCATACAAATGTATGTTAAGCCATTTGAACATCCGAGTAAAAAGCAAGTCACTAACCTTTTTAAAAAAGTTAAAAAGCTAAAAACACCTCTTATCAGTGATGAAGTACTACAAACAAGTACGTATATCGGTTGGAATGATATTGCTTCAAATAGAAAATTCATCATTTATTATGATAACTTTGGAAAATTAAACGGTGTATACGGAGACATTTCTAACCAAACTGTCAAAGGTTTCTGCTCTATTTGCAATAAAGAATCCCGTGTTGCTCTATTTATGCGAAAAACACGTACTGGCAATGATGGCCAATATACCAAAAAAGGTGACTACATTTGTTTTGATAGCACATTATGTAACCATCAAATATCCGATTTATCGCACTTCCATCATTTTTTGAATAAGATTCAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus saprophyticus", "NCBI_taxonomy_id": "29385", "NCBI_taxonomy_cvterm_id": "40387"}, "protein_sequence": {"GI": "WP_011303797", "sequence": "MEKQLYPYQFNYIKERVAHLVNAYNSVNDPNTIASIKDVTRDEILSTFNSRNTTIRSNVEKLMNVQLTKEQAQKILTTIQMYVKPFEHPSNKQVTNLFKKVKKLKTPLISDEVLQTSTYIGWNDIASNRKFIIYYDNFGKLNGVYGDISNQTVKSFCSICNKESRVALFMRKTRTGNDGQYTKKGDYICFDSTLCNHQISDLSHFHHFLNKIQ"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "39458": {"category_aro_name": "fusidic acid resistance gene", "category_aro_cvterm_id": "39458", "category_aro_accession": "3003024", "category_aro_description": "Genes that confers resistance to fusidic acid"}}, "ARO_name": "fusD", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40386", "model_name": "fusD", "model_type_id": "40292"}, "2249": {"model_id": "2249", "ARO_accession": "3003573", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"3337": "Q72K", "3336": "G68D", "3335": "H159D"}, "clinical": {"3337": "Q72K", "3336": "G68D", "3335": "H159D"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane", "model_sequences": {"sequence": {"3505": {"dna_sequence": {"fmax": "2256463", "fmin": "2255674", "accession": "CP010781.1", "strand": "-", "sequence": "TTAGCGCACAATTCCACGCTCTGATTGTTCAAGAGAATCAATCAAGAGTTGAGCTTCTGGAACTGAAGGTAAAATTTCACTTTTAATTTGGTCAATAGCTTGAACAGAAGTTAATCCAGATTTAAATATCAATTTATAAGCTTCTCTTAAGCCTTGAATTGTATTTTTAGACCAACCTTTTCTTCGCATACCTTCAATATTTATACCAAACGCATGTGCAGGGTTACCAGAAGCCATCACATAGGCTGGAACATCTTTAAGGATCAAAGAAGCCCCACCAATCATGCTATAAGAATCGATCTTACAGAATTGATGAATTCCAGAATTACCACCCACAATAACGTGATCACCAATATGTACATGTCCAGCGACACCTACATTATTAGCAAAGATATTATGGTCACCTACGATACAATCATGTGCAATATGTGTATTTACCATTAATAGGTTATGACTACCTATCTTGGTTAATGCATTATCTTGCACCGTACCTCTATGTAAGCTGCAATGTTCGCGAATTAGATTATTGTTACCAATTTCAAGCCACGTTTCTTCACCTTTATATTTGAGGTCTTGGCAAACTTCGCCAACACTTGCAAATTGAAAGATTTCGTTATTTTGGCCAATTCTGGTAAAACCACCTACAACCACATGAGAATGTAATTTAGTACCAGCACCAATAGTCACTTGAGGACCGATAATACAATAAGGTCCTATTTGAACATCTGAAGCAATCACTGCAGATGGATCAATAATGGCGGTAGAATGGATTAAATCGTGATTGCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"GI": "AJF82049.1", "sequence": "MSNHDLIHSTAIIDPSAVIASDVQIGPYCIIGPQVTIGAGTKLHSHVVVGGFTRIGQNNEIFQFASVGEVCQDLKYKGEETWLEIGNNNLIREHCSLHRGTVQDNALTKIGSHNLLMVNTHIAHDCIVGDHNIFANNVGVAGHVHIGDHVIVGGNSGIHQFCKIDSYSMIGGASLILKDVPAYVMASGNPAHAFGINIEGMRRKGWSKNTIQGLREAYKLIFKSGLTSVQAIDQIKSEILPSVPEAQLLIDSLEQSERGIVR"}}}}, "ARO_category": {"39418": {"category_aro_name": "polymyxin resistance gene", "category_aro_cvterm_id": "39418", "category_aro_accession": "3002984", "category_aro_description": "Genes conferring resistance to polymyxins"}, "36021": {"category_aro_name": "gene conferring antibiotic resistance via molecular bypass", "category_aro_cvterm_id": "36021", "category_aro_accession": "3000012", "category_aro_description": "Genes involved in restructuring of the cell wall"}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "LpxA", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40183", "model_name": "LpxA", "model_type_id": "40293"}, "2262": {"model_id": "2262", "ARO_accession": "3003745", "model_param": {"blastp_evalue": {"param_value": "1e-80", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "mefC is a macrolide efflux gene isolated from a plasmid in Photobacterium damselae.", "model_sequences": {"sequence": {"3516": {"dna_sequence": {"fmax": "145536", "fmin": "144312", "accession": "AB571865", "strand": "-", "sequence": "TTAAATATTTTTGATTTTACCTAATTGCATTAAGTTGCGAGTGCTAAACGAAAGAATACCCACAAGGATTGCCAAACAACCGCTTATGATAAACGTAATGTTTACACCAATAACTTCTGCAATCAGGCCTGTGAATAATAAACCGATTACACTTGGCAAAACTGCCAAACTATAATAAAGTGAAAATACACGTCCTAATTTTTCAGGACTTACCTCTGTTTGTACAATTGCTGTAAAACAGCCATTGAAAACAGACAGGCTGATACCGCCAATGGCTGTTACCATCACAAATCCTACAAACCAACTTGCAGGTAATACACCACTCAAAATAAATGTAAGTCCCAATAATACATACATAACATTGACTGCGACTACTTTTGAGCCTTTCAATTTGAAAATACTCAGGATGACACCGCCAATAAGCATACCTCCGCCCCAAACCACTTCTACAATTCCTATCTCCCATTTTCCTCCTGCAAAATGCCCTGTTGTGAGCAACGGAAACATAATGGCAGCTGGCATTATAACAAAGGTTATCGCCATTGCATAAAGAAAAAGATAACGCAAACCTTTGTTTTTTGAAACAGTCTGAAACCCTTCCGAAAATTCTGTAGCAATAGAATGTGCAGACGATTTTGACTTCGCAACCACATTGGGAATTTTCACCATCACGAGTGAAAGAATAGCCAGCAATGCTCCAATCAAATCCAAGTACAATACTTTTGAAATAGGAAGATAAGCAATGGCTAATGTGCCAATGGCAGGACCACCAATCCTGCAAACCGAATGTAACACCTGATTAATTCCTGCTACCTTTATCAATTCATTTTGGGGTACAATCAGCGGAGCAATTGCCTGTAGTGCCGGAGCGTGAAAAGCATTACCAACAGAGCGTAAACCCAATAAAATGTATATCCATATAAGATTAACATTTTCATTTTGTAAAATGACGAGTAACAAAAGGGCACAGAGAGCTATAAAAGCATCCGAAAAAATCATTACATATTTACGATTGAGACGGTCAACATATACACCTGCTATTAAGCCTATCAATGCTTGAGGCAACATAGCTGCTATTCCTGCGTAGGCTAAAACTTCGGCTGACTTGTACTCCAGACTAAGCCATATAACAATAGCAAACTGAACAGCATAACTTGTAAGCATTGAAGCAAACTGTCCAGCCCATATAAACATATAGGTCTTAAACCATTTACGGTTTTCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Photobacterium damselae subsp. damselae", "NCBI_taxonomy_id": "85581", "NCBI_taxonomy_cvterm_id": "40398"}, "protein_sequence": {"GI": "BAL43360", "sequence": "MENRKWFKTYMFIWAGQFASMLTSYAVQFAIVIWLSLEYKSAEVLAYAGIAAMLPQALIGLIAGVYVDRLNRKYVMIFSDAFIALCALLLLVILQNENVNLIWIYILLGLRSVGNAFHAPALQAIAPLIVPQNELIKVAGINQVLHSVCRIGGPAIGTLAIAYLPISKVLYLDLIGALLAILSLVMVKIPNVVAKSKSSAHSIATEFSEGFQTVSKNKGLRYLFLYAMAITFVIMPAAIMFPLLTTGHFAGGKWEIGIVEVVWGGGMLIGGVILSIFKLKGSKVVAVNVMYVLLGLTFILSGVLPASWFVGFVMVTAIGGISLSVFNGCFTAIVQTEVSPEKLGRVFSLYYSLAVLPSVIGLLFTGLIAEVIGVNITFIISGCLAILVGILSFSTRNLMQLGKIKNI"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}}, "ARO_name": "mefC", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40401", "model_name": "mefC", "model_type_id": "40292"}, "2260": {"model_id": "2260", "ARO_accession": "3003744", "model_param": {"blastp_evalue": {"param_value": "1e-95", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "vatF is a streptogramin A acetyl transferase gene isolated from the chromosome of Yersinia enterocolitica.", "model_sequences": {"sequence": {"3514": {"dna_sequence": {"fmax": "735", "fmin": "69", "accession": "AF170730", "strand": "+", "sequence": "ATGGAAGATAAGCCAATATTAGGGCCAGATCCCCAGTGTAAACACCCGATGGTGGGGTTTTCTCAAGTATGCTTTATCAAAAATACCACACAGAATCCGAACATTATTATCGGTGATTATACCTACTACGACGATCCACAAGATTCTGAAAACTTTGAACGTAACGTGCTTTATCACTACCCCTTTATTGGTGATAAGCTGATTATCGGCAAATTCTGTGCATTAGCTCATGGGGTGAAGTTCATTATGAATGGTGCCAACCATAAAATGTCTGGGTTATCGACTTACCCATTCAATATTTTTGGTAACGGTTGGGAAAGAGTCGCCCCGTCCAGGGATGAGCTGCCTTATAAAGGCGATACTCATGTCGGAAATGATGTGTGGATTGGCTATGATGTGTTGATTATGCCAGGTGTCACCATTGGCAATGGGGCAATTATTTCATCACGCTCAGTGGTCACGCGCGATGTGCCCGCTTATAGTGTGGTCGGCGGTAATCCCGCAACACTGATTAAAAATCGCTTCTCAGCCGAGGTTATCGGTAAGCTACAAACCATTGCCTGGTGGGATTGGCCAATAGACGCGATCAGTCGCAATCTACACCTGATCGTTGCCGGTGATATCGAGGCATTAGCGCGAGCAGCCAGCGAGATTGATCACACCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Yersinia enterocolitica", "NCBI_taxonomy_id": "630", "NCBI_taxonomy_cvterm_id": "40164"}, "protein_sequence": {"GI": "AAF63432", "sequence": "MEDKPILGPDPQCKHPMVGFSQVCFIKNTTQNPNIIIGDYTYYDDPQDSENFERNVLYHYPFIGDKLIIGKFCALAHGVKFIMNGANHKMSGLSTYPFNIFGNGWERVAPSRDELPYKGDTHVGNDVWIGYDVLIMPGVTIGNGAIISSRSVVTRDVPAYSVVGGNPATLIKNRFSAEVIGKLQTIAWWDWPIDAISRNLHLIVAGDIEALARAASEIDHT"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36379": {"category_aro_name": "streptogramin resistance gene", "category_aro_cvterm_id": "36379", "category_aro_accession": "3000240", "category_aro_description": "Genes conferring resistance to streptogramin antibiotics."}}, "ARO_name": "vatF", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40399", "model_name": "vatF", "model_type_id": "40292"}, "2261": {"model_id": "2261", "ARO_accession": "3003762", "model_param": {"blastp_evalue": {"param_value": "1e-95", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "lnuE encodes a lincosamide resistance gene isolated from Streptococcus suis that was truncated by an ISEnfa5-cfr-ISEnfa5 segment insertion. It shares the closest sequence similarity to lnuA.", "model_sequences": {"sequence": {"3515": {"dna_sequence": {"fmax": "522", "fmin": "0", "accession": "KF287643", "strand": "+", "sequence": "TTGGGAAAAAATAATGTCACAGAAAAACATCTATTTTATATTTTAGATTTACTTAAAGACCTCCAAATAACTTATTGGTTAGACGGTGGATGGGGAGTAGATGTACTCACTGGAAAGCAACAGAGAGAACACAGAGACATAGATATCGATTTTGATTCACAACATACAGACAAATTAGTTAAAAAATTAAAAGAGATTGGATACATCACAGTTGTAGATTGGATGCCTTCCAGAATGGAATTAAAACACGAAGAATACGGATATTTAGATATACATCCCTTAGATTTAAAAAAAGATGGCACAGCAACTCAAGCCGATCCAAAAGGCGGTTTTTATCTATTCGAAAAAGATTGGTTCACAACTACAAATTACAAAAATCGAAAAATACCATGCATTTCAAAAGAAGCACAACTACTTTTTCACTCTGGATATGAATTAACAGAAAAAGACCAATTTGATATTAAAAATTTAAACTCAATAAATCAAGTTAAGAAAGAAGGTCATTTTTCAAATGACTTCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "synthetic construct", "NCBI_taxonomy_id": "32630", "NCBI_taxonomy_cvterm_id": "36748"}, "protein_sequence": {"GI": "AGT57825", "sequence": "MGKNNVTEKHLFYILDLLKDLQITYWLDGGWGVDVLTGKQQREHRDIDIDFDSQHTDKLVKKLKEIGYITVVDWMPSRMELKHEEYGYLDIHPLDLKKDGTATQADPKGGFYLFEKDWFTTTNYKNRKIPCISKEAQLLFHSGYELTEKDQFDIKNLNSINQVKKEGHFSNDF"}}}}, "ARO_category": {"36380": {"category_aro_name": "lincosamide resistance gene", "category_aro_cvterm_id": "36380", "category_aro_accession": "3000241", "category_aro_description": "Genes conferring resistance to lincosamides."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}, "ARO_name": "lnuE", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40400", "model_name": "lnuE", "model_type_id": "40292"}, "2267": {"model_id": "2267", "ARO_accession": "3003751", "model_param": {"snp": {"param_type": "single resistance variant", "param_value": {"3467": "R15C", "3470": "R203C", "3471": "G131D", "3472": "S33R", "3469": "R203L", "3468": "Y45C"}, "clinical": {"3467": "R15C", "3470": "R203C", "3471": "G131D", "3472": "S33R", "3469": "R203L", "3468": "Y45C"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "nfsA encodes the major oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA.", "model_sequences": {"sequence": {"3520": {"dna_sequence": {"fmax": "891906", "fmin": "891183", "accession": "NC_000913.3", "strand": "+", "sequence": "ATGACGCCAACCATTGAACTTATTTGTGGCCATCGCTCCATTCGCCATTTCACTGATGAACCCATTTCCGAAGCGCAGCGTGAGGCGATTATTAACAGCGCCCGTGCGACGTCCAGTTCCAGTTTTTTGCAGTGCAGTAGCATTATTCGCATTACCGACAAAGCGTTACGTGAAGAACTGGTGACGCTGACCGGCGGGCAAAAACACGTAGCGCAAGCGGCGGAGTTCTGGGTGTTCTGTGCCGACTTTAACCGCCATTTACAGATCTGTCCGGATGCTCAGCTCGGCCTGGCGGAACAACTGTTGCTCGGTGTCGTTGATACGGCAATGATGGCGCAGAATGCATTAATCGCAGCGGAATCGCTGGGATTGGGCGGGGTATATATCGGCGGCCTGCGCAATAATATTGAAGCGGTGACGAAACTGCTTAAATTACCGCAGCATGTTCTGCCGCTGTTTGGGCTGTGCCTTGGCTGGCCTGCGGATAATCCGGATCTTAAGCCGCGTTTACCGGCCTCCATTTTGGTGCATGAAAACAGCTATCAACCGCTGGATAAAGGCGCACTGGCGCAGTATGACGAGCAACTGGCGGAATATTACCTCACCCGTGGCAGCAATAATCGCCGGGATACCTGGAGCGATCATATCCGCCGAACAATCATTAAAGAAAGCCGCCCATTTATTCTGGATTATTTGCACAAACAGGGTTGGGCGACGCGCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_415372.1", "sequence": "MTPTIELICGHRSIRHFTDEPISEAQREAIINSARATSSSSFLQCSSIIRITDKALREELVTLTGGQKHVAQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMAQNALIAAESLGLGGVYIGGLRNNIEAVTKLLKLPQHVLPLFGLCLGWPADNPDLKPRLPASILVHENSYQPLDKGALAQYDEQLAEYYLTRGSNNRRDTWSDHIRRTIIKESRPFILDYLHKQGWATR"}}}}, "ARO_category": {"40420": {"category_aro_name": "nitrofuratoin resistance gene", "category_aro_cvterm_id": "40420", "category_aro_accession": "3003763", "category_aro_description": "Genetic determinants which confer resistance to nitrofuratoin."}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "Escherichia coli nfsA mutations conferring resistance to nitrofurantoin", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40407", "model_name": "nfsA", "model_type_id": "40293"}, "2264": {"model_id": "2264", "ARO_accession": "3003748", "model_param": {"blastp_evalue": {"param_value": "1e-125", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion.", "model_sequences": {"sequence": {"3518": {"dna_sequence": {"fmax": "2505", "fmin": "1527", "accession": "L06249", "strand": "+", "sequence": "GTGACCGTACGGGGGCTGGTCAAGCACTACGGCGAGACCAAGGCGCTGGACGGCGTCGACCTGGACGTGCGCGAGGGCACCGTGATGGGTGTGCTCGGGCCGAACGGCGCCGGCAAGACCACCCTCGTCCGCATCCTGTCCACCCTGATCACCCCGGACTCCGGGCAGGCCACCGTGGCCGGCTACGACGTCGTACGCCAGCCCCGGCAGCTGCGCCGGGTCATCGGGCTCACCGGCCAGTACGCGTCGGTGGACGAGAAGCTCCCGGGCTGGGAGAACCTCTACCTGATCGGCCGGCTGCTGGACCTGTCCCGCAAGGAGGCCCGGGCCCGCGCCGACGAGCTGCTGGAGCGGTTCTCGCTGACCGAGGCCGCCCGGCGCCCGGCCGGCACCTACTCCGGCGGTATGCGGCGCCGACTGGACCTGGCCGCCTCGATGATCGGCCGGCCGGCCGTGCTGTACCTGGACGAGCCGACCACCGGCCTCGACCCGCGCACCCGCAACGAGGTGTGGGACGAGGTCAAGGCGATGGTCGGCGACGGCGTCACCGTGCTGCTCACCACCCAGTACATGGAGGAGGCCGAGCAGCTCGCCTCGGAACTGACCGTGGTGGACCGCGGCCGGGTCATCGCCAAGGGCGGCATCGAGGAGCTGAAGGCCCGCGTCGGCGGGCGCACCCTGCGGGTGCGGCCGGTCGACCCGCTCCAGCTGCGCCCGCTCGCCGGCATGCTGGACGAGCTGGGCATCACCGGGCTGGCTTCCACCACCGTGGACACCGAGACCGGGGCCCTGCTGGTGCCGATCCTCAGCGACGAGCAGCTGACCGCCGTGGTCGGCGCGGTCACCGCGCGCGGCATCACGCTGTCCTCCATCACCACCGAACTGCCCAGCCTGGACGAGGTGTTCCTGTCCCTCACCGGCCACCGCGCCAGTGCCCCGCAGGACGCCGAGCCCGCCCGCCAGGAGGTCGCCGTATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces antibioticus", "NCBI_taxonomy_id": "1890", "NCBI_taxonomy_cvterm_id": "36823"}, "protein_sequence": {"GI": "AAA26793", "sequence": "MTVRGLVKHYGETKALDGVDLDVREGTVMGVLGPNGAGKTTLVRILSTLITPDSGQATVAGYDVVRQPRQLRRVIGLTGQYASVDEKLPGWENLYLIGRLLDLSRKEARARADELLERFSLTEAARRPAGTYSGGMRRRLDLAASMIGRPAVLYLDEPTTGLDPRTRNEVWDEVKAMVGDGVTVLLTTQYMEEAEQLASELTVVDRGRVIAKGGIEELKARVGGRTLRVRPVDPLQLRPLAGMLDELGITGLASTTVDTETGALLVPILSDEQLTAVVGAVTARGITLSSITTELPSLDEVFLSLTGHRASAPQDAEPARQEVAV"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "oleC", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40404", "model_name": "oleC", "model_type_id": "40292"}, "2265": {"model_id": "2265", "ARO_accession": "3003749", "model_param": {"blastp_evalue": {"param_value": "1e-70", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "salA is an ABC transporter gene isolated from the chromosome of Staphylococcus sciuri conferring resistance to lincosamides and streptogramins.", "model_sequences": {"sequence": {"3519": {"dna_sequence": {"fmax": "1626", "fmin": "0", "accession": "KC693025", "strand": "+", "sequence": "ATGCTATTTTTATTTGAAGAAAAAGCATTAGAAGTTGAACATAAAGTATTAATACCCGAGTTGACTTTTTCAATAGAGGACCATGAACATTTAGCAATCGTTGGTGTTAATGGTGTTGGAAAATCAACATTATTAAAAGTCATTCATCAAGATCAATCAGTTGATTCAGCGATGATGGAACAAGATTTAACACCTTATTATGATTGGACTGTTATGGATTATATAATTGAATCATATCCTGAAATCGCAAAGATTAGATTGCAACTTAATCATACAGATATGATTAATAAATATATTGAATTAGATGGATACATTATAGAAGGTGAAATCGTAACAGAAGCAAAAAAGCTCGGAATAAAAGAGGAACAACTAGAACAGAAAATTTCTACTTTAAGTGGTGGAGAACAAACAAAAGTATCATTTTTAAAAGTGAAAATGTCTAAAGCATCATTACTATTAATCGATGAACCAACAAACCACATGGATTTAGAAATGAAGGAATGGTTGACGAAAGCTTTTAAACAAGAACAACGTGCTATATTATTTGTATCTCATGACCGAACATTTTTAAATGAAACGCCAGATGCTATATTAGAATTGAGTCTTGATGGGGCTAAGAAGTATATCGGTAAATACGATAAATACAAACAACAAAAAGATATAGAGCATGAAACATTAAAGCTACAGTATGAAAAACAACAAAAAGAACAAGCGGCCATTGAAGAAACGATTAAAAAATATAAAGCATGGTATCAAAAAGCAGAACAAAGTGCTTCTGTGAGAAGCCCATATCAACAAAAACAATTAAGTAAGTTAGCGAAACGGTTTAAATCAAAAGAACAACAATTAAATCGTAAACTTGATCAAGAGCATATCCCAAATCCACATAAAAAAGAGAAAACTTTCTCAATACAACATCATAATTTTAAATCACATTATTTAGTTCAATTTAATCATGTTTCGTTTGCTTATGATAACCGGAAAATATTCGATGATGTATCATTCTATATTAAGCGAAATCAAAATGTTATTGTTGAAGGCAGAAATGGTACAGGTAAATCAACTTTAATCAAATTGATACTCGGTGAACTCGAGCCAACTAAAGGTGATATAACTGTTCATCCAGAATTAGAAATTGGATATTTCTCTCAAGATTTTGAGAATTTAAATATGCATCATACTGTCTTAGATGAAATATTAGAAATTCCTGAAATGAAAGAAGCAGATGCAAGAACCATATTAGCAAGCTTTTATTTTGATAAAGATAGGATAAATGATGTTGTTGAAACACTATCGATGGGTGAAAAATGTAGGTTACAATTTGTAAAATTATATTTTTCAAATCCTCATATTATGATATTAGATGAGCCAACAAACTATTTCGATATTGGCATGCAAGAAAATATCATTCAATTAATACAATCATTTCAAGGTTCGGTCCTTATTGTATCTCATGATAATTATTTTAAATCACAAATTAAAGATCAGACTTGGACTATAAAAAATCATCAAATGACGCATGAAAATGTTCAAGTCAAAGATCCTATTAATACAGAATCTATGAAACATCATTTAAAAGAATTAGAACAATATACAGATGAAAGAAATCGTGAAACAGAGTTCTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus sciuri subsp. sciuri", "NCBI_taxonomy_id": "147467", "NCBI_taxonomy_cvterm_id": "40406"}, "protein_sequence": {"GI": "AGN74946", "sequence": "MLFLFEEKALEVEHKVLIPELTFSIEDHEHLAIVGVNGVGKSTLLKVIHQDQSVDSAMMEQDLTPYYDWTVMDYIIESYPEIAKIRLQLNHTDMINKYIELDGYIIEGEIVTEAKKLGIKEEQLEQKISTLSGGEQTKVSFLKVKMSKASLLLIDEPTNHMDLEMKEWLTKAFKQEQRAILFVSHDRTFLNETPDAILELSLDGAKKYIGKYDKYKQQKDIEHETLKLQYEKQQKEQAAIEETIKKYKAWYQKAEQSASVRSPYQQKQLSKLAKRFKSKEQQLNRKLDQEHIPNPHKKEKTFSIQHHNFKSHYLVQFNHVSFAYDNRKIFDDVSFYIKRNQNVIVEGRNGTGKSTLIKLILGELEPTKGDITVHPELEIGYFSQDFENLNMHHTVLDEILEIPEMKEADARTILASFYFDKDRINDVVETLSMGEKCRLQFVKLYFSNPHIMILDEPTNYFDIGMQENIIQLIQSFQGSVLIVSHDNYFKSQIKDQTWTIKNHQMTHENVQVKDPINTESMKHHLKELEQYTDERNRETEF"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36380": {"category_aro_name": "lincosamide resistance gene", "category_aro_cvterm_id": "36380", "category_aro_accession": "3000241", "category_aro_description": "Genes conferring resistance to lincosamides."}, "36379": {"category_aro_name": "streptogramin resistance gene", "category_aro_cvterm_id": "36379", "category_aro_accession": "3000240", "category_aro_description": "Genes conferring resistance to streptogramin antibiotics."}, "40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}, "ARO_name": "salA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40405", "model_name": "salA", "model_type_id": "40292"}, "2288": {"model_id": "2288", "ARO_accession": "3003779", "ARO_description": "Mutations in the Mycobacterium bovis ndh gene that results in increased resistance to isoniazid.", "model_sequences": {"sequence": {"3552": {"dna_sequence": {"fmax": "2104001", "fmin": "2102609", "accession": "AM408590", "strand": "-", "sequence": "CTAGCTGGCCACCTTAGCGCTTGCCGCTGAGCCCTGCGCCTCGGCGGCCAGCTCGGCCAGCTGTTCGAGCCGCGTTCGCGCAAATGCCTGCTGGTCGGTGATGGTCAGCTGGCCGCGGCGAGTACTGAGGAAAGTCACCGTCCACGACAGCAGAGTGGTGATCTTGGTCTTGAACCCGATCAGGTACGCCAGGTGCAGCACCAGCCAAATCAGCCAGGCGATAAAGCCGCTGAACTCAACGGGACCGATCTTGGCCACCGCCGAAAACCTCGAAACCGTGGCCATCGATCCCTTGTCGAAGTACTGGAATGGCTCACGCTCCGCCGGGTTGGCGCCGGCCAGTTCGGCCTTGATCGTGCTGGCGACGTATTTCGCCCCCTGGATGGCGCCCTGCGCCACACCCGGCACACCCTCCACAGCGGCCATATCGCCCACCACGAACACGTTCGGGTACCGGGGAATGGACAGGTCGGGCAGCACTTGGACCCGGCCGGCCCGGTCGAGCTCAACCCGTGATTGCTCGGCAAGGTCCCTGCCCAACCGACTGGCCGAAACCCCGGCCGACCAGACCTTGCAGGCCGACTCGATGCGCCGGACGGTGCCGTCGGAGTCCTTGACGGTGATGCCGTTGCGGTCGACGTCGGTGACCATCGCACCCAGCTGGATTTCCACGCCCAGCTTCTGCAACCGGGCAGCCGCCCGCTGACCGAGCTTTGCGCCCATCGGTGGCAGCACCGCCGGGGCGGCGTCAAGCAGAATCACCCGCGCCTTGGTCGAGTCGATGTGCCGGAATGCGCCCTTCAACGTGTGCTCGGCCAGCTCGGCGATCTGTCCGGCCATTTCAACACCGGTGGGGCCAGCCCCGACAACGGTGAATGTCAGTAGCTTGGCCCGCCGTTCCGGATCGCTGGACCGTTCGGCTTGCTCGAAAGCGCTCAATATGCGGCCACGCAACTCCAACGCGTCGTCGATGGACTTCATGCCGGGTGCGAATTCGGCGAAATGGTCGTTGCCGAAATAAGACTGGCCAGCACCCGCGGCGACGATCAGGCTGTCGTAGGGGGTTTGGTAGGTGTGACCGAGCAATTCCGAGACGACGCACTGCCCGGCCAGGTCGATGTGGGTGACGTTGCCCAACAGTACCTGGACATTGCGCTGCTTACGCAGCACGACCCGGGTCGGCGGAGCGATTTCTCCCTCGGAGATAATCCCGGTGGCCACTTGGTACAGCAGCGGCTGGAACAGGTGATGGGTGGTGCGCGCGATCAGCTTGATGTCAACGTCGGCCCGCTTGAGCTTCTTTGCCGCGTTTAGCCCGCCGAACCCAGATCCGATGATCACAACTCGATGCCTACGAGGTGGTTGCGCTGTGGGTTCTTGCTGGGGACTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium bovis BCG str. Pasteur 1173P2", "NCBI_taxonomy_id": "410289", "NCBI_taxonomy_cvterm_id": "40462"}, "protein_sequence": {"GI": "CAL71877", "sequence": "MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASRLGRDLAEQSRVELDRAGRVQVLPDLSIPRYPNVFVVGDMAAVEGVPGVAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAASAKVAS"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "40016": {"category_aro_name": "isoniazid resistance gene", "category_aro_cvterm_id": "40016", "category_aro_accession": "3003432", "category_aro_description": "Genetic determinants which confer resistance to isoniazid."}}, "ARO_name": "Mycobacterium bovis mutant ndh conferring resistance to isoniazid", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40461", "model_name": "Mycobacterium bovis mutant ndh conferring resistance to isoniazid", "model_type_id": "40293"}, "2281": {"model_id": "2281", "ARO_accession": "3003772", "model_param": {"blastp_evalue": {"param_value": "1e-70", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins.", "model_sequences": {"sequence": {"3545": {"dna_sequence": {"fmax": "570923", "fmin": "568280", "accession": "AE014292", "strand": "+", "sequence": "TTGCTCTGGTGGGACGACATTTCGATGAGCCTGATTGATGATGAAATACCTTCTTCGCAACCGCAAGTGTCAGGTAGGCATTTCGGCTGGTTGAAACAATATCAGCATTTTCTGTTTCCAATCGCAGGCATCGCCATTGCGTTATTGGCTATTTATGTTCTGGAAAATCTTCTCAGGCACACCTCCCGCACCGAAACGCTTGCAGCCCTTCACAATATTTCATGGACGACGCTCGCACTGGCCGTCTTTTTCACAGCATTAAGCTATGCCGCAGTGGCGCTTTATGATGTCGTGGCGGTGGACACCATAGCGCCCAACCAGATACCGCGCCGCATCGCGGCGGTGGCGGGTGCTGCGGGCTATGCGATTTCCAACGCGCTCGGCTTCTCGCTCCTGACCGGCGGGGCGCTGCGTTATCGCATTTATGCCGCAGAAGGCATAAGCCTGGCCGATATCGGCAAGATCGTCGGCACCTCATGGTTCGCCATCTGGTTCGCCCTCATCATCATGGTGGGCGCAGCCCTGCTGATCGATCCGCAGGACGTGCCTTTTCTTTCCGCCATCGATATACGGATTGATATTGTCGCAGGCATTCTCATCCTTGGCGGCATTGGCTGGCTGATCTACTGGCTTTCGCATGGCGAACGCAATGTCAGCATCGGTTCGTTCAGCCTGCGCCTGCCCAATTCAAAAGGCGCGCTCACGCAGATTTTTGCGGGCGTGGTGGATGTGGGCGCTGCCGCGGCCACGCTCTATGTGCTGTTGCCGGAAGGGGCTGTGCCAAGCTTCGCCGTCTTTGCGCTCGTTTATGTCATCGCCATCGTGCTTGGCATTGCAAGCCACGCGCCAGGCGGCCTCGGCGCTTTTGAGGCAACAATCATCGCAGGGCTTGGCCTCGGTGGAAAACCCGATGCAATTGCGGGCCTGCTGGCCTATCGCCTCATTTACACGGTTCTTCCCCTCGTGGTTGCCACCGCCGGAATCCTCATCTGGGAGGTCATGCGCCGCCGCCATATGCTCGACAAGCAGGCCCGATTCGCCAAGCGGCTGGTGGAGCCGCTGGTTCCGGGGCTTTCAGCCAGCATCATCTTTCTCGGTGGCATCATCCTGCTTATCTCAGGCGCCACGCCCGATATGCGCTATCGTGTGAAGTTGCTGTCCGACATCGTGCCGGAATTTCTTGTGGAGATGTCGCATCTGGCGGCAAGCCTCGTCGGCGTTGCTCTTCTCATCGTCGCGCGCGGCCTTTCCAAACGGCTGGAGCGCGCCTGGGTGGCCGCGATGGTGCTTCTTCTTTGCGGCGCGGTGTTTTCGATCGCAAAAGGACTGGACTGGGAAGAGGCAAGCATTTTGTGCCTTTTTGCCCTTTCACTCTGGGGCTTTCGCGATTCCTTCTACCGTCGTCCGATTGCCGGCCCGTTTGAACTGAGCTGGAACTGGATCGCAACCGTTGGAACCACGGTTCTCGTGTCCACCTGGCTTGGTTTTTTCGTCTACCGCCATATCGAATATTCAAGCGATCTCTGGTGGGATTTCGCGTGGAACGGCAACGCCCCGCGTTTCCTGCGCGCCACCGTTCTGGTTTTCGCAGTCGTGGCGGCAGTCGGCCTTCATTCGATCATCAACCGGCATGGCCAGCGCAGGCGCAAGGTTGATCATTCCATCCCCGATGCCGTGCCCGCACTCGTCGCCCGGTGCCCGCATACAGATGCAGCCCTTGCCATGCTGGGCGACAAGCAATTTCTGCTGGCGCCCGACGACAGCGCGTTCATCATGTATGCGCAGTCGGGCGGCAGCCTGATCGCGCTTGGCGAGCCTATCGGCGATGCCGAAGCGGGCAAGGAACTTGCCTGGTCTTTCCATTCGCTTGCCGACCGTCTGGCGCTGCGCACTGTCTTCTATGGTGTCGGCCCGCAAAGCCTGCCGCTTTTCCTCGATATGGGCCTGATTGCGCTCAAGCTGGGTGAAGTCGCACGCGTTGACCTGACAGATTTTTCGCTGGAAGGCCCGCGCCGCCAGCCCTTCCGTTATGCCGACCGCAAGGTGGACAAGGATGGGCTGACCTTCGAGATTATCCCTGCTGCGGACGTGCCGCCGCTGATCCCGCGCCTGCGCGCAATTTCCGACGCTTGGCTCGACCATAAATCAGGCAGCGAAAAGGGTTTTTCGCTTGGCTATTTCAACGATGAGTATTTAAAGCGTTTCGATATTGCCGTGCTGAAGAAAGACGGCGAAATCGTTGCTTTCGCCAATATATGGCGCGGTGCCGACAAGTATGAGATCACGGTCGACCTGATGCGCTACATGCCCAATGTGCACAAGCTCCTGATGGATGCGCTGTTCGCCAAGCTGCTGACCTTTTCCAAGCAAGAAGGCTACAAATGGTTCAACCTTGGCGCGGCCCCGCTTTCCGGCCTTAGCGGCAGCAGGCTTGCCTCGCGCTGGAACCGTTTCGGCTCGTTCATCTATCGCCGTGGGGCCGATCTTTATCACTTCGACGGGCTCAAAGCCTTCAAGGAAAAATTCGATCCCGTCTGGACCCCGCATTATATGGTTTGCCCCGGCGGGCTTGAAACGCCGCGCGCCCTTCTTGATGCCACAACACTGATTAACGGCAGCCCTTTGGAGTTCATTCGCAAATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Brucella suis", "NCBI_taxonomy_id": "29461", "NCBI_taxonomy_cvterm_id": "40446"}, "protein_sequence": {"GI": "Q8FW76", "sequence": "MLWWDDISMSLIDDEIPSSQPQVSGRHFGWLKQYQHFLFPIAGIAIALLAIYVLENLLRHTSRTETLAALHNISWTTLALAVFFTALSYAAVALYDVVAVDTIAPNQIPRRIAAVAGAAGYAISNALGFSLLTGGALRYRIYAAEGISLADIGKIVGTSWFAIWFALIIMVGAALLIDPQDVPFLSAIDIRIDIVAGILILGGIGWLIYWLSHGERNVSIGSFSLRLPNSKGALTQIFAGVVDVGAAAATLYVLLPEGAVPSFAVFALVYVIAIVLGIASHAPGGLGAFEATIIAGLGLGGKPDAIAGLLAYRLIYTVLPLVVATAGILIWEVMRRRHMLDKQARFAKRLVEPLVPGLSASIIFLGGIILLISGATPDMRYRVKLLSDIVPEFLVEMSHLAASLVGVALLIVARGLSKRLERAWVAAMVLLLCGAVFSIAKGLDWEEASILCLFALSLWGFRDSFYRRPIAGPFELSWNWIATVGTTVLVSTWLGFFVYRHIEYSSDLWWDFAWNGNAPRFLRATVLVFAVVAAVGLHSIINRHGQRRRKVDHSIPDAVPALVARCPHTDAALAMLGDKQFLLAPDDSAFIMYAQSGGSLIALGEPIGDAEAGKELAWSFHSLADRLALRTVFYGVGPQSLPLFLDMGLIALKLGEVARVDLTDFSLEGPRRQPFRYADRKVDKDGLTFEIIPAADVPPLIPRLRAISDAWLDHKSGSEKGFSLGYFNDEYLKRFDIAVLKKDGEIVAFANIWRGADKYEITVDLMRYMPNVHKLLMDALFAKLLTFSKQEGYKWFNLGAAPLSGLSGSRLASRWNRFGSFIYRRGADLYHFDGLKAFKEKFDPVWTPHYMVCPGGLETPRALLDATTLINGSPLEFIRK"}}}}, "ARO_category": {"36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}, "37131": {"category_aro_name": "peptide antibiotic resistance gene", "category_aro_cvterm_id": "37131", "category_aro_accession": "3000751", "category_aro_description": "Genes conferring resistance to peptide antibiotics."}}, "ARO_name": "Brucella suis mprF", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40445", "model_name": "Brucella suis mprF", "model_type_id": "40292"}, "2282": {"model_id": "2282", "ARO_accession": "3003773", "model_param": {"blastp_evalue": {"param_value": "1e-95", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins.", "model_sequences": {"sequence": {"3546": {"dna_sequence": {"fmax": "1757774", "fmin": "1756064", "accession": "CP000312", "strand": "-", "sequence": "TTATTTTTTCTCTACTCTTTCCTTTGAATTAGCTATTAATAAACATAAGTTAATAAACACCTCTGGTAAGGACATAAACTTAGGATATGCTAAATATCTAGGTTGCCAAATTGGAGAAAACTTTGACTTATATCTTCTTAGTCCATCAAAACTATAGAATATATTACCACTATTATAAACTAACCTTGCAAGCTTTTCTTGTAAATGTGAATGAGTGTTAAATCCTACATTAGATAATGGTGCTTCTCCTAAGCTAAAATACTTATATCCTTTTTCTTTAAAGGTTAAGAATAAATTAAGCATTAGGTAATCCATAGAGGCATTTGGAGCATCTTTATCTATTCTCATTAAATCTATTGCTACTGTCTCCCCTCCATCATTAGCATCCATTATTGTTACAAAGCCCATAATCTTATTTTCTTCTTCATTCTTTAAAATAGCTATAGGTGATCTTTGTATATAATCCTCACTAAACCATCCTAAAGAAAATCCCTTTTCTTTTCTGTCCCCTAACCATTTATCAGATATTTCCTTCAATTGACTTACTACCTCATTATTAAAAGGAGGCTCTATAATGCTAAAATTATATCCTTCCCTTTCAACTCTTCTTAAGGTGTTTCTAAAGGCACTCTTTTTAGAACCAATCAAATTAAATTCTTCTAAATCTATCCTTGCCTCTTCTCCTAACTTAAAGAAATAATACCCTGCATCATGATAGGTAGAAAAGTTTTTTTCTTCTATTTCATAAAAGACAACATCATATCCATATAAATTTGTAAAAGCTTGAAACTCTTCTATACAACTATATAGGTTTTCCTTAGTAGCTATAGGATCTCCTAAAACTATTATCTTATCTTTGTACTTGCTATACATTATTAAGGACTCTCCTTCATTAGCCCAAAAGACCTTTTTATCCTTTAAATAAACTAAATGGGAGAATATTGTTCCATAATCTATTTCTTTAAAGAATTTTGATACCTTTTCTAAATCAGCATCCATATACCTTTCGTCATCTTCTATTTTAGGCATTGTTAAATACCATATTATCACAAATATTATAAAGGATATATATGTGAATAATGCTATTCTTAAATACCCCTTTGTGCTATGGAAAAAGTCTATATAGTATTTATAGTTCTTGCTAAAATGTATGTTAAATTTATGTATAAAACTCGCAAAGATAATCATTACAATTGAAAGAACTATTAATATCCCACTTAATTTAGTAACCTTAATAGGAATACTTTTTCTGTAAAAACTCTTTTTTGATAATATTAGAAGTATTATTACTCCTAAAATAAAAATTCCTTCTTTGTAATCTAAATCTTTTATAAAGGCAAAGGCTCCTCCTACTATAAGCAATGTTAATGTAACATAATAAGCTCTTTTTACCTTAAAGAAAACTTCCTTAGAGGTCATTATTAACATTAATCCAATTAATATTGAAGCTCTATGTGAAAACCTTAAAAAAGATAAACTGTATATATTATCTAAAAATTTTATCTTATAAAATATACTAGGATAAATCCCTGAAATTATTAAAAGAATACCACTTAGAAATACCAAAACTGATACTATTATATTTGATATATCACTTAAGATTTTGTAATTTTTTAATAGCTTCTTTATATTTTCATAATTTCTTTTATCAGTAACAAATCCTAAAATATTTTTTAAATGTCTATAACTTTTTTTTAGTGAATCCCACAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Clostridium perfringens SM101", "NCBI_taxonomy_id": "289380", "NCBI_taxonomy_cvterm_id": "40448"}, "protein_sequence": {"GI": "Q0SSM7", "sequence": "MWDSLKKSYRHLKNILGFVTDKRNYENIKKLLKNYKILSDISNIIVSVLVFLSGILLIISGIYPSIFYKIKFLDNIYSLSFLRFSHRASILIGLMLIMTSKEVFFKVKRAYYVTLTLLIVGGAFAFIKDLDYKEGIFILGVIILLILSKKSFYRKSIPIKVTKLSGILIVLSIVMIIFASFIHKFNIHFSKNYKYYIDFFHSTKGYLRIALFTYISFIIFVIIWYLTMPKIEDDERYMDADLEKVSKFFKEIDYGTIFSHLVYLKDKKVFWANEGESLIMYSKYKDKIIVLGDPIATKENLYSCIEEFQAFTNLYGYDVVFYEIEEKNFSTYHDAGYYFFKLGEEARIDLEEFNLIGSKKSAFRNTLRRVEREGYNFSIIEPPFNNEVVSQLKEISDKWLGDRKEKGFSLGWFSEDYIQRSPIAILKNEEENKIMGFVTIMDANDGGETVAIDLMRIDKDAPNASMDYLMLNLFLTFKEKGYKYFSLGEAPLSNVGFNTHSHLQEKLARLVYNSGNIFYSFDGLRRYKSKFSPIWQPRYLAYPKFMSLPEVFINLCLLIANSKERVEKK"}}}}, "ARO_category": {"36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}, "37131": {"category_aro_name": "peptide antibiotic resistance gene", "category_aro_cvterm_id": "37131", "category_aro_accession": "3000751", "category_aro_description": "Genes conferring resistance to peptide antibiotics."}}, "ARO_name": "Clostridium perfringens mprF", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40447", "model_name": "Clostridium perfringens mprF", "model_type_id": "40292"}, "2283": {"model_id": "2283", "ARO_accession": "3003774", "model_param": {"blastp_evalue": {"param_value": "1e-130", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins.", "model_sequences": {"sequence": {"3547": {"dna_sequence": {"fmax": "2113820", "fmin": "2111276", "accession": "AE009948", "strand": "-", "sequence": "TTATTTAACAATCTTAATTTTACTATCTTCCATTAATAGGGCACAAATAGCACAAATTAACCAGGACGAACGAGAACAAGAAATATAACGTTCCGACCACAATGGTGTAAACTTCTTCTTATACTTGTGTAAACCATTAAATGAGTAGAAATGACTACCGAAATGATAGACAAGATACGCCATTCTCTCTTTAGCAAAACTTGTTTCAACGCGACCAACTCCTGATAAAGGTGCCATCCCCAAATCAAAATAGTGGTATCCCTTCTCTTGATAATAAGAGAATAATGATAAAAAGAGGAAATCCATAACGCCATTCGGAATTTTCTGTTTATCGTGACGCATTAAATCAATAGAGATAATACTCTTTTCATAGTTTGGCATAATATTAGCAAAAGCAACAACTTCGTGTTCAGCATTTTTTACCAAAGCTATTGGGGCTTGTTGGAAATAATCTTTATTAAAATATCCTAGTGAGAAACCTTTTTCAGGACGTCCTTCTAACCAAGTATTAGAAATCTCTTCCAAACTATTTAGTAGCTCTTGACTATGTGGCGATTGTACAACTTCGAAATAGAAACCATCCTTTTCAACTCTATTTAGGGCATTTCTGAAAGGTTTGTACTTATTCCCTTTAAGAGTAAACGTTTCTAAATTAACTAAAGCATCCTCACCAACTTTCATAAAGTCAAAACCATACTCATGTAAAAGTAGTGTCAACTTCTGTCCAATACTGTAAAAAACAAGGTCATAGTCTAGCTTATCAGCATCATCAATAAACGATTCAATAGCTTCACGAATATAAGTGTCATCACCGGCTGGTTCCCCCATAATAAGACATTTATTATTGACAATTACAAATTGGAACGCAACGCAATCTTCTCCATTTTTTTGGTACCAGTAGAGCCTTTTATCATTTAAAAAGGCTAAACCGCTATCCGAAGAACCACCGTAAGCTTGAAGTAGTTTTTTATAACGATCCACATTGAACACATCACCAATCTGACAAGATTTTCCTTGTAAAATCTTAACCAAACATAAATAAACGAGAGTAAGAATCAACGTAGCCAATGCTATCGGCTCCCATGCTATGATATAATGCAGGCGTTCAATACTACCACCTGTAATATGAGCCCTGATAGGGAATAGTAGTCCTGCAATATAAAATAGAACTCCCATTAAACTAACGATAATGATTCCATCCTTAATACGCTCTTCCCAGCTATAAATAAATTGTTTTTTATAGAGAGTTGGCTTAATGACTAATAAGCCTAACAATAGTAAAATAAACCAGAAAGATAGTCGCCAACTAATATGACCTAAATTAAGATAAAACAATGTCAAAGTAATCCAGATAATAGCAATTGGAAAAGCATTTTTCACTTTTTGATCAATAGTTCTAGCTAAGAGAATAAAACAAACCCCCAGCAATAAACCTGGAAACTGCCATAACATTTGTTCTTGTAATGGGTCCAAGCCTAGCTTCTGCAACCACATAATATAAGTAATATTTTCAAAAAATGCTGTTGAAAATATTAAGAATGCACCTAAAATACGCATCAAATGGCTCACCATGGTTTGTAGAACAGTTGATACTAACTCTTTCGGGACATTTTCATAACGTTGATTTATTTGACTACCTAAATAATGGATAAAGAAATAGATACCTGCAAAGAATGGAATAATATAGTAGGCTAAACGATAAAGTAATAACCATGCAACCACAGTTTCTTTAGGTAGTCCCTCGGCAGCAAACCCTGTAAATAGAACTAATTCAAAACTTCCTAATCCACCGGGAATAAGGGATACAATCCCGACGGCACAACCAATACAAAATAGTGGTAAAATTTTATAAACTGGTAGATGAATGCCCATTAAATAACCGATAATTATAAATGCTGCGGCCGCACATCCCCATTCAAAAAAAGAAACAACACCTAATTTTATACGAGTACTAGATGGCATATCTCCGAAATAATGGCTTCCTTTATGACCAGAAATCCAATAAATAACAGGAAAATACATACTAGCACCAATTAATACCAAATAATAGTAATCAACACTAGCTTTGGCATGAAAAATATGGCTCATGATTAAGGCAATCACACTAATAAATGACAGACCAGAAATAAGATAGGGTAAAAAACGAGTCACTTCTCTTAGGTCACTCTTCTCTTGACCTTTTTTACCATAAAAAGCCATGCGCAACCCAATATCGATTAAGCCACCGAATCCTGACAAGTTATTAAAAGTGTTGATACACCAACTAGTCTGTAAAATATACCTTTTGCTTTTATCTGTACGTAAAAGTCCATTCAGTACAAAGTCATATCCGGTTGTCGGTAAGACAGCGATAACCCCCACAAGGATAATTAAGAAAAGATTCATTGGAGATAATTGCCCAAAAACACTCTTTAGTTGCTCAACAGAAATAGTTCGTTTCAAATGAATCATTTCAACAATAATAAGCACTAAAACAGATATAAAAAATACAATTTTAATCACAGAAGTCAGTGATTTGACTTTTTCAATTAGCTTTTTCAACAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus agalactiae serogroup V", "NCBI_taxonomy_id": "216466", "NCBI_taxonomy_cvterm_id": "40450"}, "protein_sequence": {"GI": "Q8DWT2", "sequence": "MLKKLIEKVKSLTSVIKIVFFISVLVLIIVEMIHLKRTISVEQLKSVFGQLSPMNLFLIILVGVIAVLPTTGYDFVLNGLLRTDKSKRYILQTSWCINTFNNLSGFGGLIDIGLRMAFYGKKGQEKSDLREVTRFLPYLISGLSFISVIALIMSHIFHAKASVDYYYLVLIGASMYFPVIYWISGHKGSHYFGDMPSSTRIKLGVVSFFEWGCAAAAFIIIGYLMGIHLPVYKILPLFCIGCAVGIVSLIPGGLGSFELVLFTGFAAEGLPKETVVAWLLLYRLAYYIIPFFAGIYFFIHYLGSQINQRYENVPKELVSTVLQTMVSHLMRILGAFLIFSTAFFENITYIMWLQKLGLDPLQEQMLWQFPGLLLGVCFILLARTIDQKVKNAFPIAIIWITLTLFYLNLGHISWRLSFWFILLLLGLLVIKPTLYKKQFIYSWEERIKDGIIIVSLMGVLFYIAGLLFPIRAHITGGSIERLHYIIAWEPIALATLILTLVYLCLVKILQGKSCQIGDVFNVDRYKKLLQAYGGSSDSGLAFLNDKRLYWYQKNGEDCVAFQFVIVNNKCLIMGEPAGDDTYIREAIESFIDDADKLDYDLVFYSIGQKLTLLLHEYGFDFMKVGEDALVNLETFTLKGNKYKPFRNALNRVEKDGFYFEVVQSPHSQELLNSLEEISNTWLEGRPEKGFSLGYFNKDYFQQAPIALVKNAEHEVVAFANIMPNYEKSIISIDLMRHDKQKIPNGVMDFLFLSLFSYYQEKGYHYFDLGMAPLSGVGRVETSFAKERMAYLVYHFGSHFYSFNGLHKYKKKFTPLWSERYISCSRSSWLICAICALLMEDSKIKIVK"}}}}, "ARO_category": {"36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}, "37131": {"category_aro_name": "peptide antibiotic resistance gene", "category_aro_cvterm_id": "37131", "category_aro_accession": "3000751", "category_aro_description": "Genes conferring resistance to peptide antibiotics."}}, "ARO_name": "Streptococcus agalactiae mprF", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40449", "model_name": "Streptococcus agalactiae mprF", "model_type_id": "40292"}, "2284": {"model_id": "2284", "ARO_accession": "3003775", "model_param": {"blastp_evalue": {"param_value": "1e-20", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"3623": "D369N", "3624": "L370I"}, "clinical": {"3623": "D369N", "3624": "L370I"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species.", "model_sequences": {"sequence": {"3548": {"dna_sequence": {"fmax": "1416077", "fmin": "1414817", "accession": "CP009072", "strand": "+", "sequence": "ATGGATAAATTTCGTGTTCAGGGGCCAACGAAGCTCCAGGGCGAAGTCACAATTTCCGGCGCTAAAAATGCTGCTCTGCCTATCCTTTTTGCCGCACTACTGGCGGAAGAACCGGTAGAGATCCAGAACGTCCCGAAACTAAAAGACGTCGATACATCAATGAAGCTGCTAAGCCAGCTGGGTGCGAAAGTAGAACGTAATGGTTCTGTGCATATTGATGCCCGCGACGTTAATGTATTCTGCGCACCTTACGATCTGGTTAAAACCATGCGTGCTTCTATCTGGGCGCTGGGGCCGCTGGTAGCGCGCTTTGGTCAGGGGCAAGTTTCACTGCCTGGCGGTTGTACGATCGGCGCACGTCCGGTTGATCTACACATTTCTGGCCTCGAACAATTAGGCGCGACCATCAAACTGGAAGAAGGTTACGTTAAAGCTTCCGTCGATGGTCGTTTGAAAGGCGCACATATCGTGATGGATAAAGTCAGCGTTGGCGCAACGGTGACCATCATGTGTGCTGCAACCCTTGCGGAAGGCACCACGATTATTGAAAACGCAGCGCGTGAACCGGAAATCGTCGATACCGCGAACTTCCTGATTACGCTGGGTGCGAAAATTAGCGGTCAGGGCACCGATCGTATCGTCATCGAAGGTGTGGAACGTTTAGGCGGCGGTGTCTATCGCGTGCTGCCGGATCGTATCGAAACCGGTACTTTCCTGGTGGCGGCGGCGATCTCTCGCGGCAAAATTATCTGCCGTAACGCGCAGCCAGATACTCTGGACGCCGTGCTGGCGAAACTGCGTGACGCTGGAGCGGACATCGAAGTCGGCGAGGACTGGATTAGCCTGGATATGCATGGCAAACGTCCGAAGGCTGTTAACGTACGTACCGCGCCGCATCCGGCATTCCCTACCGATATGCAGGCCCAGTTCACGCTGTTGAACCTGGTGGCAGAAGGGACCGGATTCATCACCGAAACGGTCTTTGAAAACCGCTTTATGCATGTGCCAGAGCTGAGCCGTATGGGCGCGCACGCCGAAATCGAAAGCAATACCGTTATTTGTCACGGTGTTGAAAAACTTTCTGGCGCACAGGTTATGGCAACCGATCTGCGTGCATCAGCAAGCCTGGTGCTGGCTGGCTGTATTGCGGAAGGGACGACGGTGGTTGATCGTATTTATCACATCGATCGTGGCTACGAACGCATTGAAGACAAACTACGCGCTTTAGGTGCAAATATTGAGCGTGTGAAAGGCGAGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli ATCC 25922", "NCBI_taxonomy_id": "1322345", "NCBI_taxonomy_cvterm_id": "40452"}, "protein_sequence": {"GI": "AIL15701", "sequence": "MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE"}}}}, "ARO_category": {"36410": {"category_aro_name": "fosfomycin resistance gene", "category_aro_cvterm_id": "36410", "category_aro_accession": "3000271", "category_aro_description": "Genes conferring resistance to fosfomycin."}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "Escherichia coli mutant murA conferring resistance to fosfomycin", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40451", "model_name": "Escherichia coli mutant murA conferring resistance to fosfomycin", "model_type_id": "40293"}, "2286": {"model_id": "2286", "ARO_accession": "3003777", "ARO_description": "murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Mutations to the murA enzyme confers resistance to the antibiotic.", "model_sequences": {"sequence": {"3550": {"dna_sequence": {"fmax": "1284", "fmin": "0", "accession": "NC_001318", "strand": "+", "sequence": "TAAATATAATTTAATAGTATAAAAAAAATTAAATCAAATTAATAATAGTTTAAAAAACTGTTTGTATAATATAATATTATTATATATAATATTAAGCAACTACTATGATACTAATGAAGTATAGTGCTATTTTATTAATATGTAGCGTTAATTTATTTTGTTTTCAAAATAAATTAACTACTTCTCGATGGGAATTCCCTAAAGAAGATTTAATTAAAAAAAAAATAAAAATAGGCATAATTTACCATAATTACATAAATTCTATCTTTTACAATGAAAATTATAAATACATTGCCTTTATCGGAATATTGACATCTTATAATGAATGGATTGAAATACAATTTAGCCCCATAAATTTTTTTACTATCCCAACAAATAAAGATTTTATTTCAAATACTTATTTCAATTTAGCTTTCACTATTTACATTACCAAGTATTCAATTTTAACTGATACACTTGCTATAAAATTTTTTATTGGAACCCAAATCGATTTAACTCTGAGAACTACTATATTTACAGGAAAAACAACTCATGCATTTCTCTATCCAATTCTTCCCATAATTACCTTCAAATTTGAAATTGATTTCATACCTAATAACTATAGTATTTACTATAAATTATCGACTTCTTTTAAAGAATTTATCCTTTTAGATCTAGGAATTTCTATATTTATATAATCCTTTTTTTATTATAGAACTTTTTTTATGGTATAAATTATTTAACACAAATTGTAAAAAGACCAAAAACAAATTTTCAAAACAATTTCACTAAGGAATGAGTACTATATTGACACCCGAACTCAAAGACTTTTTAATAGCATTTTCAATATTAGAAAAACTTCTTGTAATTGCTCCCATATCATAAGAATCTGTCATCATAATACTAGTAATATTTAAATTTTCCCTTATAATATTAACAATACTTTTAGACATGCTAGTTATATCTTTAGAAATTTTAGGAACATTTACATGACCAATCATAATAAATTTAGCAGCTCTACCAAAAACAAATGGAACAAAATTATTTAACATTAAAAAGCTTTTACTATAAGGCAAAAATGCTAAATATTTATGTGTATCTGTAGTTGTTCCCCCTAATCCAGGAAAATGTTTGATTGCCGAAAATACTCCATTATTCTGCATACCATCAATAAAAGCTTCTACCATAAGTCCAATATTATAAGCGGAATATCCTCCAAATGTCCTATTTAATAAAGGAGTATGTGGTGCAAATTTTATATCGGCAACTGGAGCCATATTTAAATTAATACCCAATCTACGCAAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Borrelia burgdorferi B31", "NCBI_taxonomy_id": "224326", "NCBI_taxonomy_cvterm_id": "40455"}, "protein_sequence": {"GI": "NP_212606", "sequence": "MHSYIVEGGYKIGGQITASGNKNAALPCILAALLTDEEVILENIPNINDVKVVLDILNDIGADIAREGNTLKIKVLNIVKTEIDSSFTDLIRASILLLGPFVSRFGKIDMALPGGDVIGKRRLDTHFYGLCKLGAKLSTKDRRIVLKANKLVGAEMFLDEASVTATENIIMAAVLAEGNTVIMNAACEPHVQDLCNMLNSMGANILGIGSNVLEIKGVKKLSGTVFRIGADFMQVGSLISLAALTGGELEIKKADPQHFRLIRHVYSRLGINFEYDRENVYVRNKQELKVKLDFGGHIPKIDDGPWPAFPTDLMSIIVVTATQVEGTVLVFEKMFESRMFFVDKLIKMGARIVLCDPHRVVVTGKSSLKGNVLSSPDVRAGMSLLIAAFVAEGRSEIQNVYQIERGYEDVVNKLINLGAKIKKVKSQ"}}}}, "ARO_category": {"36410": {"category_aro_name": "fosfomycin resistance gene", "category_aro_cvterm_id": "36410", "category_aro_accession": "3000271", "category_aro_description": "Genes conferring resistance to fosfomycin."}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "Borrelia burgdorferi mutant murA conferring resistance to fosfomycin", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40454", "model_name": "Borrelia burgdorferi mutant murA conferring resistance to fosfomycin", "model_type_id": "40293"}, "2287": {"model_id": "2287", "ARO_accession": "3003778", "ARO_description": "Mutations in the Mycobacterium smegmatis ndh gene that results in increased resistance to isoniazid.", "model_sequences": {"sequence": {"3551": {"dna_sequence": {"fmax": "3685431", "fmin": "3684057", "accession": "NZ_CP009496", "strand": "+", "sequence": "ATGAGCCATCCCGGAGCTACGGCGTCGGATCGGCATAAAGTCGTCATCATCGGTTCGGGTTTCGGTGGTCTCACCGCTGCCAAGACCCTCAAGCGCGCTGACGTCGACGTCAAGCTAATCGCCCGTACCACGCACCACCTCTTCCAGCCGCTGCTCTACCAGGTGGCGACCGGCATCATCTCCGAGGGCGAGATCGCCCCGGCCACTCGAGTGATCCTCCGCAAGCAGAAGAACGCCCAGGTCCTTCTCTGCGATGTGACGCACATCGATCTGGAGAACAAGACCGTGGATTCGGTGCTGCTCGGTCACACCTACTCGACGCCCTACGACAGCCTCATCATCGCCGCGGGCGCGGGTCAGTCCTACTTCGGCAACGACCACTTCGCCGAGTTCGCACCCGGCATGAAGTCGATCGACGATGCGCTGGAGCTGCGCGGTCGCATCCTCGGCGCGTTCGAACAGGCCGAGCGCTCCAGCGACCCGGTGCGCCGCGCGAAGTTGCTGACGTTCACCGTCGTCGGCGCGGGCCCGACCGGCGTCGAGATGGCCGGACAGATCGCCGAATTGGCCGACCAGACTTTGCGGGGCAGCTTCCGCCACATCGATCCCACCGAGGCCCGGGTGATCCTGCTCGACGCCGCACCGGCCGTGCTACCGCCCATGGGCGAGAAGCTCGGCAAGAAGGCGCGGGCCCGTCTGGAGAAGATGGGCGTCGAGGTCCAGCTGGGTGCGATGGTCACCGACGTCGACCGCAACGGCATCACCGTCAAGGATTCCGACGGGACCATCCGTCGCATCGAGTCGGCGTGCAAGGTGTGGTCGGCCGGTGTGTCGGCCAGCCCTCTCGGCAAGGATCTCGCCGAGCAGTCGGGTGTCGAACTCGACCGCGCGGGCCGGGTCAAGGTACAGCCCGACCTGACGCTGCCCGGTCACCCGAACGTGTTCGTCGTGGGCGACATGGCGGCCGTCGAGGGCGTGCCCGGTGTGGCGCAGGGCGCCATCCAGGGTGGCCGCTACGCCGCGAAGATCATCAAGCGTGAGGTCAGTGGCACCAGCCCGAAGATCCGCACGCCGTTCGAGTACTTCGACAAGGGCTCGATGGCGACGGTGTCGCGGTTCTCCGCGGTGGCCAAGGTGGGTCCCGTCGAGTTCGCGGGCTTCTTCGCCTGGTTGTGCTGGCTCGTGCTGCACCTGGTGTACCTGGTCGGGTTCAAGACGAAGATCGTCACACTGCTGTCGTGGGGCGTGACGTTCCTGAGCACCAAGCGTGGTCAGCTCACCATCACCGAGCAGCAGGCCTATGCGCGAACCCGCATCGAGGAGCTCGAGGAGATCGCGGCGGCGGTGCAGGACACCGAGAAAGCCGCGTCCTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium smegmatis", "NCBI_taxonomy_id": "1772", "NCBI_taxonomy_cvterm_id": "36871"}, "protein_sequence": {"GI": "WP_038583059", "sequence": "MSHPGATASDRHKVVIIGSGFGGLTAAKTLKRADVDVKLIARTTHHLFQPLLYQVATGIISEGEIAPATRVILRKQKNAQVLLCDVTHIDLENKTVDSVLLGHTYSTPYDSLIIAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILGAFEQAERSSDPVRRAKLLTFTVVGAGPTGVEMAGQIAELADQTLRGSFRHIDPTEARVILLDAAPAVLPPMGEKLGKKARARLEKMGVEVQLGAMVTDVDRNGITVKDSDGTIRRIESACKVWSAGVSASPLGKDLAEQSGVELDRAGRVKVQPDLTLPGHPNVFVVGDMAAVEGVPGVAQGAIQGGRYAAKIIKREVSGTSPKIRTPFEYFDKGSMATVSRFSAVAKVGPVEFAGFFAWLCWLVLHLVYLVGFKTKIVTLLSWGVTFLSTKRGQLTITEQQAYARTRIEELEEIAAAVQDTEKAAS"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "40016": {"category_aro_name": "isoniazid resistance gene", "category_aro_cvterm_id": "40016", "category_aro_accession": "3003432", "category_aro_description": "Genetic determinants which confer resistance to isoniazid."}}, "ARO_name": "Mycobacterium smegmatis mutant ndh conferring resistance to isoniazid", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40460", "model_name": "Mycobacterium smegmatis mutant ndh conferring resistance to isoniazid", "model_type_id": "40293"}, "2275": {"model_id": "2275", "ARO_accession": "3001293", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "B-Glycosidase involved in Streptomyces venezuelae self-resistance. This organism produces pikromycin/narbomycin/methymycin/neomethymycin which are inactivated by a glucosyltransferase inside the cell. DesR is a secreted enzyme that re-activates the antibiotic by removing the glucose once it is pumped out of the cell.", "model_sequences": {"sequence": {"3535": {"dna_sequence": {"fmax": "6054", "fmin": "3624", "accession": "AF079762.1", "strand": "+", "sequence": "GTGACAGGTAAGACCCGAATACCGCGTGTCCGCCGCGGCCGCACCACGCCCAGGGCCTTCACCCTGGCCGTCGTCGGCACCCTGCTGGCGGGCACCACCGTGGCGGCCGCCGCTCCCGGCGCCGCCGACACGGCCAATGTTCAGTACACGAGCCGGGCGGCGGAGCTCGTCGCCCAGATGACGCTCGACGAGAAGATCAGCTTCGTCCACTGGGCGCTGGACCCCGACCGGCAGAACGTCGGCTACCTTCCCGGCGTGCCGCGTCTGGGCATCCCGGAGCTGCGTGCCGCCGACGGCCCGAACGGCATCCGCCTGGTGGGGCAGACCGCCACCGCGCTGCCCGCGCCGGTCGCCCTGGCCAGCACCTTCGACGACACCATGGCCGACAGCTACGGCAAGGTCATGGGCCGCGACGGTCGCGCGCTCAACCAGGACATGGTCCTGGGCCCGATGATGAACAACATCCGGGTGCCGCACGGCGGCCGGAACTACGAGACCTTCAGCGAGGACCCCCTGGTCTCCTCGCGCACCGCGGTCGCCCAGATCAAGGGCATCCAGGGTGCGGGTCTGATGACCACGGCCAAGCACTTCGCGGCCAACAACCAGGAGAACAACCGCTTCTCCGTGAACGCCAATGTCGACGAGCAGACGCTCCGCGAGATCGAGTTCCCGGCGTTCGAGGCGTCCTCCAAGGCCGGCGCGGCCTCCTTCATGTGTGCCTACAACGGCCTCAACGGGAAGCCGTCCTGCGGCAACGACGAGCTCCTCAACAACGTGCTGCGCACGCAGTGGGGCTTCCAGGGCTGGGTGATGTCCGACTGGCTCGCCACCCCGGGCACCGACGCCATCACCAAGGGCCTCGACCAGGAGATGGGCGTCGAGCTCCCCGGCGACGTCCCGAAGGGCGAGCCCTCGCCGCCGGCCAAGTTCTTCGGCGAGGCGCTGAAGACGGCCGTCCTGAACGGCACGGTCCCCGAGGCGGCCGTGACGCGGTCGGCGGAGCGGATCGTCGGCCAGATGGAGAAGTTCGGTCTGCTCCTCGCCACTCCGGCGCCGCGGCCCGAGCGCGACAAGGCGGGTGCCCAGGCGGTGTCCCGCAAGGTCGCCGAGAACGGCGCGGTGCTCCTGCGCAACGAGGGCCAGGCCCTGCCGCTCGCCGGTGACGCCGGCAAGAGCATCGCGGTCATCGGCCCGACGGCCGTCGACCCCAAGGTCACCGGCCTGGGCAGCGCCCACGTCGTCCCGGACTCGGCGGCGGCGCCACTCGACACCATCAAGGCCCGCGCGGGTGCGGGTGCGACGGTGACGTACGAGACGGGTGAGGAGACCTTCGGGACGCAGATCCCGGCGGGGAACCTCAGCCCGGCGTTCAACCAGGGCCACCAGCTCGAGCCGGGCAAGGCGGGGGCGCTGTACGACGGCACGCTGACCGTGCCCGCCGACGGCGAGTACCGCATCGCGGTCCGTGCCACCGGTGGTTACGCCACGGTGCAGCTCGGCAGCCACACCATCGAGGCCGGTCAGGTCTACGGCAAGGTGAGCAGCCCGCTCCTCAAGCTGACCAAGGGCACGCACAAGCTCACGATCTCGGGCTTCGCGATGAGTGCCACCCCGCTCTCCCTGGAGCTGGGCTGGGTGACGCCGGCGGCGGCCGACGCGACGATCGCGAAGGCCGTGGAGTCGGCGCGGAAGGCCCGTACGGCGGTCGTCTTCGCCTACGACGACGGCACCGAGGGCGTCGACCGTCCGAACCTGTCGCTGCCGGGTACGCAGGACAAGCTGATCTCGGCTGTCGCGGACGCCAACCCGAACACGATCGTGGTCCTCAACACCGGTTCGTCGGTGCTGATGCCGTGGCTGTCCAAGACCCGCGCGGTCCTGGACATGTGGTACCCGGGCCAGGCGGGCGCCGAGGCCACCGCCGCGCTGCTCTACGGTGACGTCAACCCGAGCGGCAAGCTCACGCAGAGCTTCCCGGCCGCCGAGAACCAGCACGCGGTCGCCGGCGACCCGACAAGCTACCCGGGCGTCGACAACCAGCAGACGTACCGCGAGGGCATCCACGTCGGGTACCGCTGGTTCGACAAGGAGAACGTCAAGCCGCTGTTCCCGTTCGGGCACGGCCTGTCGTACACCTCGTTCACGCAGAGCGCCCCGACCGTCGTGCGTACGTCCACGGGTGGTCTGAAGGTCACGGTCACGGTCCGCAACAGCGGGAAGCGCGCCGGCCAGGAGGTCGTCCAGGCGTACCTCGGTGCCAGCCCGAACGTGACGGCTCCGCAGGCGAAGAAGAAGCTCGTGGGCTACACGAAGGTCTCGCTCGCCGCGGGCGAGGCGAAGACGGTGACGGTGAACGTCGACCGCCGTCAGCTGCAGACCGGTTCGTCCTCCGCCGACCTGCGGGGCAGCGCCACGGTCAACGTCTGGTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces venezuelae", "NCBI_taxonomy_id": "54571", "NCBI_taxonomy_cvterm_id": "36873"}, "protein_sequence": {"GI": "AAC68679.1", "sequence": "MTGKTRIPRVRRGRTTPRAFTLAVVGTLLAGTTVAAAAPGAADTANVQYTSRAAELVAQMTLDEKISFVHWALDPDRQNVGYLPGVPRLGIPELRAADGPNGIRLVGQTATALPAPVALASTFDDTMADSYGKVMGRDGRALNQDMVLGPMMNNIRVPHGGRNYETFSEDPLVSSRTAVAQIKGIQGAGLMTTAKHFAANNQENNRFSVNANVDEQTLREIEFPAFEASSKAGAASFMCAYNGLNGKPSCGNDELLNNVLRTQWGFQGWVMSDWLATPGTDAITKGLDQEMGVELPGDVPKGEPSPPAKFFGEALKTAVLNGTVPEAAVTRSAERIVGQMEKFGLLLATPAPRPERDKAGAQAVSRKVAENGAVLLRNEGQALPLAGDAGKSIAVIGPTAVDPKVTGLGSAHVVPDSAAAPLDTIKARAGAGATVTYETGEETFGTQIPAGNLSPAFNQGHQLEPGKAGALYDGTLTVPADGEYRIAVRATGGYATVQLGSHTIEAGQVYGKVSSPLLKLTKGTHKLTISGFAMSATPLSLELGWVTPAAADATIAKAVESARKARTAVVFAYDDGTEGVDRPNLSLPGTQDKLISAVADANPNTIVVLNTGSSVLMPWLSKTRAVLDMWYPGQAGAEATAALLYGDVNPSGKLTQSFPAAENQHAVAGDPTSYPGVDNQQTYREGIHVGYRWFDKENVKPLFPFGHGLSYTSFTQSAPTVVRTSTGGLKVTVTVRNSGKRAGQEVVQAYLGASPNVTAPQAKKKLVGYTKVSLAAGEAKTVTVNVDRRQLQTGSSSADLRGSATVNVW"}}}}, "ARO_category": {"36631": {"category_aro_name": "gene involved in self resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}}, "ARO_name": "desR", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "37692", "model_name": "desR", "model_type_id": "40292"}, "2274": {"model_id": "2274", "ARO_accession": "3001301", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "RlmA(II) is a methyltransferase found in Streptococcus pneumoniae and confers resistance to mycinamicin, tylosin and lincosamides. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA.", "model_sequences": {"sequence": {"3534": {"dna_sequence": {"fmax": "2149772", "fmin": "2148923", "accession": "CP007593.1", "strand": "+", "sequence": "ATGAATACAAATCTCAAGCCCAAACTTCAGCGTTTTGCTTCTGCGACTGCCTTTGCCTGTCCTATCTGTCAAGAAAATCTGACTCTGTTAGAGACTAATTTCAAGTGCTGCAACCGTCATTCTTTTGACTTGGCGAAATTTGGCTATGTCAATCTAGCACCTCAAATCAAGCAATCTGCTAACTATAACAAGGAAAATTTTCAAAACCGTCAACAAATCCTAGAAGCCGGCTTTTACCAAGCTATCTTAGATGCTGTATCTGACTTGCTTGCAAGCTCAAAAACTACCACAACAATTTTGGATATCGGTTGTGGTGAAGGATTCTATTCTCGCAAACTACAAGAAAGTCACTCTGAAAAAACTTTCTATGCCTTTGACATCTCCAAAGATTCAGTCCAAATCGCTGCTAAAAGTGAACCCAACTGGGCAGTCAATTGGTTTGTTGGCGACTTGGCACGACTTCCTATAAAAGACGCTAACATGGATATTCTGCTTGATATCTTCTCACCTGCCAACTATGGAGAATTTCGTCGCGTTTTATCCAAAGACGGTATCTTGATAAAGGTTATCCCAACTGAAAATCACCTCAAAGAAATCCGTCAAAGAGTACAGGACCAGCTGACAAACAAGGAGTATTCTAACCAAGATATCAAGGAGCATTTCCAGGAACACTTTACCATCCTATCTAGTCAAACTGCCTCTCTGACTAAGACTATCACAGCAGAACAACTCCAAGCCCTACTCAGTATGACTCCTCTCCTCTTTCACGTTGACCAGAGCAAGATTGACTGGAGCCAACTGACAGAGATTACCATCGAAGCAGAGATTTTGGTTGGGAAAGCATTCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus pneumoniae", "NCBI_taxonomy_id": "1313", "NCBI_taxonomy_cvterm_id": "35917"}, "protein_sequence": {"GI": "AJD73064.1", "sequence": "MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNRHSFDLAKFGYVNLAPQIKQSANYNKENFQNRQQILEAGFYQAILDAVSDLLASSKTTTTILDIGCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDLARLPIKDANMDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIKEHFQEHFTILSSQTASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSQLTEITIEAEILVGKAF"}}}}, "ARO_category": {"36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}, "36631": {"category_aro_name": "gene involved in self resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}, "36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}}, "ARO_name": "RlmA(II)", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "37700", "model_name": "RlmA(II)", "model_type_id": "40292"}, "2277": {"model_id": "2277", "ARO_accession": "3003767", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Bacillus Cluster B mph are chromosomally-encoded macrolide phosphotransferases that inactivate 14-, 15- and 16-membered macrolides.", "model_sequences": {"sequence": {"3539": {"dna_sequence": {"fmax": "20020", "fmin": "19120", "accession": "AHFH01000066.1", "strand": "-", "sequence": "CTAGCGGTCATTCACTTGCAATGTTTCTTTCGCCATCTGCTCATATTCTTCCAAACCTGAGATAATCGCAAACTCAGCTATCGCAACAGGGTATGCAGCATTAAGTTCAATGACGTGCTCTTTCATGGCAGGCCAGTAAATTCCGCCTGCTTGCCGGTAATGTTGGATCAGTTTCTCCAGGGATGCTTCCCCAAATGCCCGGTACTGGAAAACAAAGTCATTTGATACATCCGTTACTTTTGCTTCAGTCCAGTCGATTAAACCGGTTACGTTAGCATCTTTATCAATCATCGTGTGGCCAGCATGAACATCACCGTGAATCAGGCCTGTTTTCTGCGGCCACAATTCTTCATTTTTTATCCAGGCCTGCCAGCGGTTCCATAAGGATTTTCCTACATCAAACTTCGCCTTAACCTTTTCCATACGCTCAATCATCGATTTTCTGGCCTCTTCTGCTGTCTGGACAAAAAGGCCTACTTTAAGAGCCTCTTCTTTCGGAATTGTGTGTAGCGAAGCCAACGCTTTGGCTAATGTCTGGTGAAATCGTTCAGGTACATTTTCATAATCCATCTCCCACAAATAATTTTGAATCTCTGGATCAATTGTGCCTGCTGGCACTCCGGTTAACTTTTTATAAGCTATTAGATCGTTTTTATAAAGCGACCAGACTGGAACCTGAAAAGTGGCATATTTGTTTACAAGATCCAGTGCTTTCTTCTCCACTATAGTCCTAGGCATCACATCGTCTCGTCTCGGAAACCTTAGCACCCATTCTTCGCCTTTATAATCTTCTGCATACGCAACTAGAAAATCTAAACCGGACTCGTTGAATATAATGGATCCCTCTTTAACTTCCAAGCCATACTTTCTTGCTATTTCTATCGCTTTTTGTTTGTTCAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacillus cereus VD156", "NCBI_taxonomy_id": "1053239", "NCBI_taxonomy_cvterm_id": "39616"}, "protein_sequence": {"GI": "EJR71705.1", "sequence": "MNKQKAIEIARKYGLEVKEGSIIFNESGLDFLVAYAEDYKGEEWVLRFPRRDDVMPRTIVEKKALDLVNKYATFQVPVWSLYKNDLIAYKKLTGVPAGTIDPEIQNYLWEMDYENVPERFHQTLAKALASLHTIPKEEALKVGLFVQTAEEARKSMIERMEKVKAKFDVGKSLWNRWQAWIKNEELWPQKTGLIHGDVHAGHTMIDKDANVTGLIDWTEAKVTDVSNDFVFQYRAFGEASLEKLIQHYRQAGGIYWPAMKEHVIELNAAYPVAIAEFAIISGLEEYEQMAKETLQVNDR"}}, "3540": {"dna_sequence": {"fmax": "4143", "fmin": "3243", "accession": "AHEL01000071.1", "strand": "-", "sequence": "CTAGCGGTCATTCACTTCCAATGTTTCTTTCGCCATCTGCTCATATTCTTCCAAGCCTGAGATAATCGCAAACTCAGCTATCGCAACAGGGTATGCCGCATTAAGTTCAATGACGTGCTCTTTCATGGCAGGCCAGTAAATCCCACCTGCTTGCCGGTAATAGTTGATCAGTTTCTCCAGGGCTGCCTCCCCGAATACCCGGTACTGGAAAACAAAGTCATTTGATACATCCGTTACTTTTGCTTCGGTCCAGTCGATAAAACCTGTTAAGTTAGCATCTTTATCAATCATCGTGTGGCCAGCATGAACATCCCCATGAATCAGACCTGTTCTCTGAGGCCACAATTCCTCATTTTTTACCCAGGCCTGCCAGCGGTTCCATAAGGATTCGCCTACGCCAAACTTCGCTTTAACCTTTTTCATACGCTCAATCATCGATTTTCTTGCCTCTTCTGCTGTCTGGACAAACAGGCCTACTTTAAGAGCCTCTGTTTTCGGAACTGTGTGTAGCGAAGCCAACGCTTTGGCTAATGTCTGGTGAAATTGTTCAGGCACATTTTCATAATCCATCTCCCACACATAGTTTTGAATCTCCGGATCAATCGTGCCTGCTGGCACTCCGATTAACTTTTTATAAGCTATTAGATCGCCTTCATAAACCGACCAGACTGGAACCTGAAAAGTGGCATATTTATTTACAAGATCCAGTGCTTTCTTCTCCACTATCGTCCTTGGCATCACATCGTCCCGTCTCGGAAACCTTAGCACCCATTCTTCGCCTTTATCGTCTTCTGCATAAGCAACCAGAAAATCTAAACCGGACTCGTTGAATATGATGGACTCATCTTTAACTTCCAAACCATACTTTCTTGCTATTTCTACCGCTTTCTGTTTGTTCAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacillus cereus K-5975c", "NCBI_taxonomy_id": "1053217", "NCBI_taxonomy_cvterm_id": "39641"}, "protein_sequence": {"GI": "EOO80837.1", "sequence": "MNKQKAVEIARKYGLEVKDESIIFNESGLDFLVAYAEDDKGEEWVLRFPRRDDVMPRTIVEKKALDLVNKYATFQVPVWSVYEGDLIAYKKLIGVPAGTIDPEIQNYVWEMDYENVPEQFHQTLAKALASLHTVPKTEALKVGLFVQTAEEARKSMIERMKKVKAKFGVGESLWNRWQAWVKNEELWPQRTGLIHGDVHAGHTMIDKDANLTGFIDWTEAKVTDVSNDFVFQYRVFGEAALEKLINYYRQAGGIYWPAMKEHVIELNAAYPVAIAEFAIISGLEEYEQMAKETLEVNDR"}}}}, "ARO_category": {"36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}, "ARO_name": "Bacillus Cluster B intrinsic mph", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40436", "model_name": "Bacillus Cluster B intrinsic mph", "model_type_id": "40292"}, "2273": {"model_id": "2273", "ARO_accession": "3001297", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "B-Glycosidase involved in Streptomyces antibioticus self-resistance. This organism produces oleandomycin which is inactivated by glucosyltransferase (OleI or OleD) inside the cell. OleR is a secreted enzyme that re-activates the antibiotic by removing the glucose once it is pumped out of the cell.", "model_sequences": {"sequence": {"3533": {"dna_sequence": {"fmax": "14769", "fmin": "12459", "accession": "AF055579.2", "strand": "-", "sequence": "TCACGGCGCCGTGGCGCTGAGCGGGAGACGGCCGAGGGACGGGCCCACCATGACCTGCCGTCCGGGTCCGGTCACCCAGGTGTGGGCGCCGCTGTCCCAGTTCTGGAGGGCCCTGCGCTCGACGTGCAGGGTCAGCCTCCTGCTCTCGCCCGGCCGCAGCTCGACCTTCCCGTAGGCCGCCAGGGCACGCTTGGCCTGCGCCACCCGCACGTGCGGGGACGGCCCCACGTAGACCTGCGGGACCTCCTTGCCGGTGCGCGTACCGGTGTTGCGCAGCGTGAAGCAGACGTCGAGCCCGCCGTCCGCCGTCGCCGTCACCTTCAGGTCCCGGTAGTCGAAGGAGGTGTAGCACAACCCGTGGCCGAAGGAGAACAGCGGCTGGACGCCCTGCTGTTCGTACCAGCGGTAGCCGGAGTAGATGCCCTCGGAGTAGTCCAGTTGGTCATCGACTCCCGGGTAGCGCCTGGCGTCCCCGGCGAACGGCGTCTGCCCCTCGTCGGCCGGGAAGGTCTGGGTCAGCCGGCCTCCTGGGTCGGCGTCGCCGAACAGCAGGGCGGTGGTCGCCTCGGCGCCGGCCTGGCCCGGGTACCACATGGTGAGCACCGCGGCGGTCTTCCTCAGCCAGGGCATGGTGAGGGAGGAGCCCGTGTTGAGCACCACCACGGTCCGTGGGTTGACCGCGGCCACGGCGCTGATCAGGTCGTCCTGGCGGCCGGGCAGGGACAGCGACGTGCGGTCCCCGTCCTCCGAGCCGTCGTCGTACGCGAAGACGACCGCGGTCCTCGCCGTCCGCGCGATCGACACGGCCCGGTCGATCGCCTCCTGGGCGGCCTGCGGAGTGACCCACGTCAGCTCGAAGGTCATGGGCGACTTCGCCAGGGCCGCGCCGGTGATGCGCAGCTTGTGCGTTCCGGCCGCCAGCCGCATGGGGCGGCTGCTGACGTCGCCGTAGACCCAGGGCCGACGGCCGAACGGCTCCTGGCCGTCGAGTTCGACGTAGGCGTTGCCGCCCTGCGCGCGGGCCGCGATGCGGTAGCTGCCGGTGACCGGCACGGTGATGGTGCCGTCGTAGAGGACACCGCCCCCACCGGCGGGGAACACCTCGCCCGAGGGGCGGGGCCGCGGAAGAGGGGCGGACTGCGGAACGGGAACCCCGACCGTCTCCTCACCGGTGCTGTAGCGCACGGTGCTGCCGGCGCCGGCCCGTTCGCGGATGGTGTCCAGAGGGGCGGACGCGCCGTCCGGCACGATGTACGAACTGCCCAGCCCGGTCACCTTCGGGACCTTGGCGGTGGGGCCGATCACGGCGATGTCCGCCGCCGTCTCCGTGGTCAGGGGAAGGGTGGCGCCCTCGTTGCGCAGCAGGACCGCGCCGTCCTCGGCGACCTGGCGCGCGACCTTCAAGCCGCCCGCGAGGTCGCGCGCCGGGCGGGCGGGCGGATCCTCGTCCAGCAGCCGGAACCGGGCCATCTGCGACACGATGCGGGTGACGGCCTCGTCGAGGGCCGACTCGGGGATGCGTCCCTCCCGGATCGCCGTCTTGAGCGGGTCGCCGAAGAACTTGCCGCCGGGTATCGGCTCGCCCGGGGCGGGTTCGTGGTCCAGCTCGATGCCGAGTTCCTGGTCGAGCCCCTTGGTGAGGGCGTCCGTGCTCTGCGTCGCCAGCCAGTCCGAGGTCACCCAGCCACGGAACTTCCACTGCTCCTTGAGGACCTTGTTCAGCAGTTCGTCACTGCCGCAGGCCGGCTGGCCGTTGACCTTGTTGTAGGCGCACATCACCGAGCCGGTTCCGGCAGCCACGGCGCTCTCGAAACCGGGCAGTTCCCGCTCGCGCAACGTCTGTTCGTCGACGTTCACGTTAACGCTGAAACGATTCTTCTCCTGGTTGTTCGCCGCGTAGTGCTTGGTGGCGGCGATCAGCCCCTGACTCTGGATGCCCTTGATCTCCGCGGCGGCCATCCGCGAGGTGACCAGGGGGTCCTCGCTGAACGTCTCGAAGTTCCGCCCGGCGTACGGCACGCGTATGGAGTTCACCATCGGCGCGAACACCACGTCCTGCCCGAAGGCGCGCCCCTCCCGGCCGATCACCGCCCCGTAGGACCGCGCCAGGCCGTCGTCGAAGGTGGAGGCCAGCGCCACGGGAGCGGGCAGCGCGAGGGACGGCCGGTGGATCGTGATTCCGGCGGGACCGTCGGTGGCCCGCATCTCGGGTATGCCGAGGCGGGGAACGCCCGGCAGGTACACCTTTGCCGACTCATCGCTCGTGTGATAGCTCCAGTGCACGAACGACAGCTTTTCTTCCAGGGTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces antibioticus", "NCBI_taxonomy_id": "1890", "NCBI_taxonomy_cvterm_id": "36823"}, "protein_sequence": {"GI": "AAC12650.1", "sequence": "MTLEEKLSFVHWSYHTSDESAKVYLPGVPRLGIPEMRATDGPAGITIHRPSLALPAPVALASTFDDGLARSYGAVIGREGRAFGQDVVFAPMVNSIRVPYAGRNFETFSEDPLVTSRMAAAEIKGIQSQGLIAATKHYAANNQEKNRFSVNVNVDEQTLRERELPGFESAVAAGTGSVMCAYNKVNGQPACGSDELLNKVLKEQWKFRGWVTSDWLATQSTDALTKGLDQELGIELDHEPAPGEPIPGGKFFGDPLKTAIREGRIPESALDEAVTRIVSQMARFRLLDEDPPARPARDLAGGLKVARQVAEDGAVLLRNEGATLPLTTETAADIAVIGPTAKVPKVTGLGSSYIVPDGASAPLDTIRERAGAGSTVRYSTGEETVGVPVPQSAPLPRPRPSGEVFPAGGGGVLYDGTITVPVTGSYRIAARAQGGNAYVELDGQEPFGRRPWVYGDVSSRPMRLAAGTHKLRITGAALAKSPMTFELTWVTPQAAQEAIDRAVSIARTARTAVVFAYDDGSEDGDRTSLSLPGRQDDLISAVAAVNPRTVVVLNTGSSLTMPWLRKTAAVLTMWYPGQAGAEATTALLFGDADPGGRLTQTFPADEGQTPFAGDARRYPGVDDQLDYSEGIYSGYRWYEQQGVQPLFSFGHGLCYTSFDYRDLKVTATADGGLDVCFTLRNTGTRTGKEVPQVYVGPSPHVRVAQAKRALAAYGKVELRPGESRRLTLHVERRALQNWDSGAHTWVTGPGRQVMVGPSLGRLPLSATAP"}}}}, "ARO_category": {"36631": {"category_aro_name": "gene involved in self resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}}, "ARO_name": "oleR", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "37696", "model_name": "oleR", "model_type_id": "40292"}, "2279": {"model_id": "2279", "ARO_accession": "3003770", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins.", "model_sequences": {"sequence": {"3543": {"dna_sequence": {"fmax": "1761291", "fmin": "1758693", "accession": "NC_003210", "strand": "-", "sequence": "TTACTCAGAATCTGGTTTTTTTGTTTCTTCTTCGAGTGGGAAATCAAGGACTACTTGGCTATTTGCAAGTGGTCGTTTTTTACCAACAAGAATCATTAATTGTAACATGGTGAAAGCAATGGAACTTCTTTTTCTAAAGGCAACAAATTTTTGTTCCCATTCTGTAACATATTTGGATTTAAAATTACGTAATCCTTTGAAACCGTAAAAACCTTGACTATAACGGTATACAAGTCCGGCTAATCGTTCACCTAGGAAAGCATATTTACTTTCCCCAACATTGGCAAGTGGTGCCATACCGGCATTAAATGTTTGGAAGCCATCTTCTTTGGCTTTTTCGAATAGGTTAATGAAAAGGAAATCCATAATACCTGATGGCGCTTCTTTGGAGTAACGCATTAAATCAATCGAAGTCATTTCGTCTGTATATGACGGCATCATCGAAGCAAATCCAACGATAGTACCTTCTCCGTTTTTAGCGATAGCAATCGGAGCTTGTTCGAGATAATACGTATCGAAGAATCCTAATGAGAAACCTTTTTCTTCCCTACCATCTAGCCACTCATCAGAAACTGCTCGTAAAGTTGTCCAAGTGTCGTGATTGAATGGTGGTTCTATTATTTCAAAAGTATAACCTTCTCGTTCTAATTTATTCATGAGAGCTCGCTCACCTTTTTTCTTTTTACCACTCATTGTAAAGTTTTGGACGTCGACAAAACCTTCCTCGCCAAGCTTGATAAAGTCAAATCCGTGATCATGTAAATATGGAATCATCGTGCCCCGGACTTCATAGAAAACAGGTCGATAGCCAAATCTATCAGCGTTCATCATTACCTCTTCAATCGCTGCTTCCATTTTGTCCATGTTCCCAGTTGGTTCGCCCATGATGACCATTTTGTCCGCAATGATTCGGTAAGAGAAAAGTACTTCCCCCTCTGCTGCCCAAAATAGCAGTTTATCACGTAAGAACATCGTATGACTGACTTCATTTCCGCCCCATTTCGCTAAATGTTCGCGTACTTTGACTGCTTCAAATGGAGAGCCAAGTTTTTCTTTTGTTGTGGATAAATAAATGTAAATAATGACTAAACTAACAACGGCGATAAATACGCCAACGAAGCCGACTAACCATAAATGCTCTGAGGCAATGCGTAAATAGTCAGGGATTTCTTTGGAGTGTTTGATATTTGGTGAGTTGTAAATACCGATAACAATGTAACCTGCCAGACATACGATGAAAATAATGCTATCAATAATTACTTTACTCCAAGTATAAACCAGTTTTTCTCGGTAAAATTCGTTTCGAGCTAAGAATAAACATAACAGCACAATTCCTAAAAAGATTGCCTGCTTCATCGAAAATACGCGAGCAAGTGTGTTGAAAATCGCGCAACCTAGAACAATTACTGTAATAATATACGCTTTCTTTGTTTTACATTCAATCCCTCTCGCAAGCCCCAGTAGTAAAAAGCCAAATGCAACAATGGTAATTTGGGAAGTGAATAAGAAATTAAACGGCATAATTTTGTATAAGAATGGCACATGGTAAATAGCGTTTGGTACGGCGGAAGACAAAATTAACAATAACCCAGAGCCGTAAACAAAAATAACTAAGAAGCGATGGGCCACTTTTTGTAAGAATAATAACGGTAATCCTTCTAAAAAGTCATTTACTTTTTTACCAGCTTTTTGGACGAAGAAAAGTAGTCCCACTACAAAAGGAATAATATAGTAGAAAATTCGGTAAAATAGCATCCAAGCGAGCGCTAATTCTTGAGAAACACCTAATTGGCTAAGTCCAAGAATCATCACGACGTCAAATGTCCCTACTCCACCAGGTACCATCGAAGCAATCCCAATTACCGAAGCAATAACAAATAACGGGAACACTTTGAAAATATCGACTGGTTCTCCCATCAATGTACCGATAATCGCGAAACATCCAAAAGCGAAGCCCCACTCCAAAAGAGAAGCGATAATTAACGTTAATTCTCTTTTGATAGGTAAATCAACAAAGAGTGACTTACTTTTCCATTTCGTAATAGTAAATAAAATCGGGAAGTAAAGACCACCCGCAAGAAGCCATGGCCAGTAATTAACAAAATGATCTGCAAATCCTGGAATGAGTAAAGTGGCTAATGATACTAAACAGTAAATCGATAAACCAGATACTAAAAATAAAGCAATCTTAGAAATAGCTAGTAAAATTTCCTTATGAGATGCATTTTTCCCATAAAAACTTGCTCTTAAACTGGCACCTAATACGCCACCAAAACCGCCAATATTAGTAAAGGTATTCGTAATCCAACCAGAGGCAATCACATGACTTGGCGAAAACTTTCCAGGTAACAACTTAACGATGACATAATCATACAAAAGCATTGGAGTGACAGCAATTAAGCCCACGATAAACATAATAAATATTTGTTCCGGGCTTTGAGAAGTTAAATTTTCTTTTAGCGACGGATAGTCAATCCCCGTCGCAATATTAATAATTTCAAAAATAACAAAAGCCATCACAAAAGTAATAAAAACGATTTTTACGACGGTACTATTTTTTTGAAACCAGGCATAGGCTTGCATTAATTTTTCTTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Listeria monocytogenes EGD-e", "NCBI_taxonomy_id": "169963", "NCBI_taxonomy_cvterm_id": "40443"}, "protein_sequence": {"GI": "NP_465220", "sequence": "MKEKLMQAYAWFQKNSTVVKIVFITFVMAFVIFEIINIATGIDYPSLKENLTSQSPEQIFIMFIVGLIAVTPMLLYDYVIVKLLPGKFSPSHVIASGWITNTFTNIGGFGGVLGASLRASFYGKNASHKEILLAISKIALFLVSGLSIYCLVSLATLLIPGFADHFVNYWPWLLAGGLYFPILFTITKWKSKSLFVDLPIKRELTLIIASLLEWGFAFGCFAIIGTLMGEPVDIFKVFPLFVIASVIGIASMVPGGVGTFDVVMILGLSQLGVSQELALAWMLFYRIFYYIIPFVVGLLFFVQKAGKKVNDFLEGLPLLFLQKVAHRFLVIFVYGSGLLLILSSAVPNAIYHVPFLYKIMPFNFLFTSQITIVAFGFLLLGLARGIECKTKKAYIITVIVLGCAIFNTLARVFSMKQAIFLGIVLLCLFLARNEFYREKLVYTWSKVIIDSIIFIVCLAGYIVIGIYNSPNIKHSKEIPDYLRIASEHLWLVGFVGVFIAVVSLVIIYIYLSTTKEKLGSPFEAVKVREHLAKWGGNEVSHTMFLRDKLLFWAAEGEVLFSYRIIADKMVIMGEPTGNMDKMEAAIEEVMMNADRFGYRPVFYEVRGTMIPYLHDHGFDFIKLGEEGFVDVQNFTMSGKKKKGERALMNKLEREGYTFEIIEPPFNHDTWTTLRAVSDEWLDGREEKGFSLGFFDTYYLEQAPIAIAKNGEGTIVGFASMMPSYTDEMTSIDLMRYSKEAPSGIMDFLFINLFEKAKEDGFQTFNAGMAPLANVGESKYAFLGERLAGLVYRYSQGFYGFKGLRNFKSKYVTEWEQKFVAFRKRSSIAFTMLQLMILVGKKRPLANSQVVLDFPLEEETKKPDSE"}}}}, "ARO_category": {"36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}, "37131": {"category_aro_name": "peptide antibiotic resistance gene", "category_aro_cvterm_id": "37131", "category_aro_accession": "3000751", "category_aro_description": "Genes conferring resistance to peptide antibiotics."}}, "ARO_name": "Listeria monocytogenes mprF", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40442", "model_name": "Listeria monocytogenes mprF", "model_type_id": "40292"}, "2278": {"model_id": "2278", "ARO_accession": "3003730", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Bifidobacteria have an intrinsically resistant form of ileS (isoleucyl-tRNA synthetase) that confers resistance to mupirocin.", "model_sequences": {"sequence": {"3541": {"dna_sequence": {"fmax": "1613960", "fmin": "1610636", "accession": "NC_014638", "strand": "-", "sequence": "TCACGCCTTGGCGACCTCCACGCCCAGCTCGGCACCTTCCTTCACCGCGAAGGAGGTGGCCAGCGTCTCATGGGCGATCAGATCGCGGAACCGCTCGACATCGGCCACATTGGCGGACGGCACGGTCAGCACCAGGGCGATGCGATCGGCGATGTCCAGGTCGGCGGCCTTGCGGGCGTCCTGCACGGCGCGAATCACGTCGCGGGCGTAGCCCTCGGCCTCCAGGTCGGCGGTCAGCACGGTATCGAGAATCACGAAACCGCCGGTAGGCAGAGCGGCCGACACGGAAGCGTCGGCCTCGGCGGCGTTCTCCTCCTCCACGCGGTTGATTAGCTCGTATTCGCCAGCCTCCAGCGCAACCTCGCCGTTCGGCGTCTCGACGACCGGAGCACCGGTCGCGGCATCGACATGCCAGGCACCGGTCTTGGACGCCTTGATGGCGAACTGGACCTGCTTGCCGAGGCGCGGGCCGGCGGCGCGGGCGTTGACCTTCAGCTCGTGCACGATCTTCAGCCCCTGCGAACCGGCATCCTCCATCGTGCAGAACTCAATATCCTTTATATTAAGCTCTGACTTGAGAATTTCGTCGTACGCCTTGACGGCATCCACATCCTCGACCACGACGGTGAGCTTGGCGAGCGGCTGGCGCACACGGATCTGGGCGGCCTTGCGCAACGACAGAGCGCCGGAGACGATCTCGCGCACCTTCTCCATCGCGTCCACCAGTGCCGGGTCGTCGACCAGCACACGGCCAAGCTCGGTCGCCTCACCGGTCTTCTCGTCCGCGACGTACGGCCAATCGGCCAGATGCACGGATTCGCCGCCGGTCAGGCCACGCCACACGGATTCGGACTCCATCGGGGCGAGCGGCGCGAGAACGCGCATGAACACCTCAAGCACGGTGTACAGCGTGTTGAACGCATTCACGTCCTCCTTCCAGAAGCGATCACGGGTGTTGCGGATGTACCAGTTGGTGAGCACGTCGATGAAGTCACTCGCCGCATCGCACGCGTCAGAAATCGCGAACTCGTCGAGCGACTTCTCTACACGCTCTACGAGCCTGCGGGTGCGGGCCAGCAGGTAACGATCCATCTCAGGCAGACCCGCCACCTCGTCCGCGCGCAGCTGACGGGCGTCGAAGCCGGCCCCGCCATTGGCCGCGTTCGCATACAGCGTGAAGAAGTAGTAGGAGCTCCACACCGGCAGCATGACCTGGCGCACGGTGTCGCGGATGCCCTCAGCGGTAACAATGAGGTTGCCGCCGCGCAGGATCGGCGACGACATAAGGAACCAGCGCATGGCGTCGGAACCGTACTTGTCGAACACGCCGTTCACGTCCGGGTAGTTGCGCAGGTGCTTCGACATCTTCTGGCCGTCGGAACCGAGCACGATGCCGTGGCAGATCACGTTCTTGAACGCCGGGCGGTCGAACAGCGCGGTGGCCATCACGTGCAGCAGGTAGAACCAGCCGCGGGTCTGGCCGATGTATTCGACAATGTAGTCGGCCGGGAAGTGCTGCTCGAACTTCTCCTTGTTCTCGAACGGGTAGTGGAACTGCGCGAACGACATCGAACCGGATTCGAACCAGCAGTCGAGCACGTCGCTGATACGGTGCATGTGGCTCTTGCCGGTCGGGTCGTCCGGGTTGACGCGCGTGAGGTTGTCGATCCACGGACGGTGCATGTTGACGTTGCCGTCCTTGTCGCGCGGGTAGTCGCCGAAGTCGGCCTTGAGCTCCTCCAACGAACCGTACACGTCGACGCGCGGGTACTTCGGGTCATCGCTCACCCACACCGGGATCGGCGAACCCCAGAAGCGGTTGCGGGAGATCGACCAGTCGCGCGCGTTGGCGAGCCACTTACCGAACTGACCATCCTTGACATTCTCAGGAATCCAGTTGATCTGCTGGTTGAGCTCCAACAGGCGCGGCTTGATCTTCGTCACCGACACGAACCATGAGCTCACAGGCTTGTAGATCAGCGGCGTGGCGCAACGCCAGCAATGCGGGTAGGAGTGCACATAGCTCTTCTCCTGGAACAGGATCGCGCGATGCTCGGCCGGGATCTCGGCCAGCGGGCCGTCTCCGTTGCGCAGGTTGCGCAGGATCGGCTTGTTCGCGTCGAACACGTACATGCCCTCGTAATCGGGGCACTGCGCGGTGAAGCGGCAGCCGGCGTCGAGCACGTCAGTGCTCTTGATGCCGTGCGCGTTCAGCGTGTTCATATCGTCCTCACCATAGGGAGCCTGGTGAACCAGGCCGGTACCCTCGACGGTGTCTACGTAGTCCGCGGTAAAGATTTGGTAGCCTTCGGGCCCCGGCACGTTGCCCTCAGACTCGGCTTTGTCGCCAGCGAAGTACGGGAACACCGGCCAGTAACGCCAACCGGCCATCTCGGAGCCCTTGAGCTCGCGCACGACCTCGTAATCCTCGCCGAGCTCCTTCTCGTACTTGGAGAGCAGGGGCTTGCCGAAGTAGAACTTCTTGCCGGCGTACTTGCCCTGCGTCGGGCGCACCTCGACATAGTCGATGTCAGCGCCGACGACGATCGCGAAGTTAGTGGGCACGGTCCACGGCGTGGTGGTCCAGAAGACCGCGTAGGCGTCCTCCTCGTCGCGCAGCTTCACGGCCACCGACACGGTGGTGTCCTGACGATCCTGATACACGTCGGCGTCCATGCGCAGCTCGTGCGCCGAAAGCGGCGTCTGATCCTTCGGGCAGTACGGCAGCACGCGGTAGCCCTGGTACGCCAGGCCCTTCTCGTACAGCTGCTTGAACGCCCACATCACCGACTCCATATACGGGATGTTCAGCGTCTTGTACCCGTGCTCGAAGTCGACCCAGCGGGCCTGACGATGCACGTAATCCTGCCATTCGTGCGTGTACTTCAGGACGGAGGCGCGGCAGGCGTCATTGAACTTGTCGATGCCCATCTTCTCGATCTGGTCGACCGAGTCGATGCCGAGCTCCTTCTGCGCCTCCAGCTCGGCGGGCAGACCGTGCGTGTCCCAGCCGAACACGCGGTTGACCTTGCGGCCCTTCATGGTCTGGTAGCGCGGGATCACGTCCTTCGCGTAACCGGTCAGCAGGTGGCCGTAGTGCGGCAGGCCGTTCGCGAACGGCGGGCCGTCGAAGAACACGAACTCGTTCTGACTATGGTCGCCGGAAGGGTTGCGTTCAACGGACTTGTTGAAGGTGTCGTCCTTGTCCCAATACTTCAGGACGGTTTCCTCCATGTTGGGGAAACTCGGGTTCGGCGCGACGCTGGCGGTCTCGCCGCCCTCGTTCGCCTTGGGATACACGTGGGAATTGGTGGTTTCGCTCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bifidobacterium bifidum PRL2010", "NCBI_taxonomy_id": "702459", "NCBI_taxonomy_cvterm_id": "40437"}, "protein_sequence": {"GI": "YP_003971446", "sequence": "MSETTNSHVYPKANEGGETASVAPNPSFPNMEETVLKYWDKDDTFNKSVERNPSGDHSQNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRKVNRVFGWDTHGLPAELEAQKELGIDSVDQIEKMGIDKFNDACRASVLKYTHEWQDYVHRQARWVDFEHGYKTLNIPYMESVMWAFKQLYEKGLAYQGYRVLPYCPKDQTPLSAHELRMDADVYQDRQDTTVSVAVKLRDEEDAYAVFWTTTPWTVPTNFAIVVGADIDYVEVRPTQGKYAGKKFYFGKPLLSKYEKELGEDYEVVRELKGSEMAGWRYWPVFPYFAGDKAESEGNVPGPEGYQIFTADYVDTVEGTGLVHQAPYGEDDMNTLNAHGIKSTDVLDAGCRFTAQCPDYEGMYVFDANKPILRNLRNGDGPLAEIPAEHRAILFQEKSYVHSYPHCWRCATPLIYKPVSSWFVSVTKIKPRLLELNQQINWIPENVKDGQFGKWLANARDWSISRNRFWGSPIPVWVSDDPKYPRVDVYGSLEELKADFGDYPRDKDGNVNMHRPWIDNLTRVNPDDPTGKSHMHRISDVLDCWFESGSMSFAQFHYPFENKEKFEQHFPADYIVEYIGQTRGWFYLLHVMATALFDRPAFKNVICHGIVLGSDGQKMSKHLRNYPDVNGVFDKYGSDAMRWFLMSSPILRGGNLIVTAEGIRDTVRQVMLPVWSSYYFFTLYANAANGGAGFDARQLRADEVAGLPEMDRYLLARTRRLVERVEKSLDEFAISDACDAASDFIDVLTNWYIRNTRDRFWKEDVNAFNTLYTVLEVFMRVLAPLAPMESESVWRGLTGGESVHLADWPYVADEKTGEATELGRVLVDDPALVDAMEKVREIVSGALSLRKAAQIRVRQPLAKLTVVVEDVDAVKAYDEILKSELNIKDIEFCTMEDAGSQGLKIVHELKVNARAAGPRLGKQVQFAIKASKTGAWHVDAATGAPVVETPNGEVALEAGEYELINRVEEENAAEADASVSAALPTGGFVILDTVLTADLEAEGYARDVIRAVQDARKAADLDIADRIALVLTVPSANVADVERFRDLIAHETLATSFAVKEGAELGVEVAKA"}}}}, "ARO_category": {"36668": {"category_aro_name": "mupirocin resistance gene", "category_aro_cvterm_id": "36668", "category_aro_accession": "3000529", "category_aro_description": "Genes conferring resistance to the antibiotic mupirocin. Mutations in ileS can confer low-level mupirocin resistance, high level resistance is conferred by the presence of alternative isoleucyl-tRNA syntheses."}}, "ARO_name": "Bifidobacteria intrinsic ileS conferring resistance to mupirocin", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40419", "model_name": "Bifidobacteria intrinsic ileS conferring resistance to mupirocin", "model_type_id": "40292"}, "2259": {"model_id": "2259", "ARO_accession": "3003742", "model_param": {"blastp_evalue": {"param_value": "1e-80", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "The mphG gene encodes a macrolide 2'-phosphotransferase found in Photobacterium damselae sharing sequence similarity to mphA in E. coli.", "model_sequences": {"sequence": {"3513": {"dna_sequence": {"fmax": "144308", "fmin": "143423", "accession": "AB571865", "strand": "-", "sequence": "CTACTCAACACCTAACTGTAATTTTGCAGAACTAAGATGAATTTCATCTTGTGTTTCTAAAGCAAAATATCCATAAGCTAGAGGTGCGGCAGCAGCTCGTTCAACTGCTTGTTCAAACAGTTTATCCCATACTTCTCCACCTTGTTTTTCGTATGCCGCAATTAAATTTTTCAGACTTTCTTCACCGAAAACAGTAACGTGACCTGAAAAATCTTGTGCTATATCGCTGACTTGTGCAGTTGACCAATCAATAATTCCACAAACTTCTCCATTATGATGAGTAAGTGTATGACCTGCATACAAATCACCGTGAATGAATTTTGTAAAATTCGGCCATAAGGCATCATTATCCAGCCATTTTTGGTACCGAAGTTCTAATTCGGCATTTATCCCTAATTCAGATTTCACCAAAATCAATCTTTCAGAAATCTCATTTCTAACCTGTTCAGGTGTCAAAATTTTTAGATTATTACGAAGTACTTCTTCCGTAGGAATTGAATGAAGTTCTATAAGTGCTTTCGCTAATGATGGTATATAAAGGTCGTTTTCTTTAGACATATTCCAGGTTACTTCATAAGTCTCCGCATCATAAGTAAGTGCAGGTTTTCCATCGAGCAAAGGATAGGCTACCAGTTTTTCATTAGCTATACGCCAATCAGGAACTTGAACCGAAAGGTATTTCGACACCAATTGAAGAATGCGTTTCTCATTCGCAATCTGTTCGCCTAAGGTTGTTCTTCTTGGAATACGCAACAACCACTTTGTGCCATCCCTATCTGTAGCGAAACCAACCTTAAAATCAATTCCCATTTCATTAAAACTCATTTCATCCGAAAGAATTAACCCATTTCTTTCCGCTAATTTTTGAATATCTCTATTTTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Photobacterium damselae subsp. damselae", "NCBI_taxonomy_id": "85581", "NCBI_taxonomy_cvterm_id": "40398"}, "protein_sequence": {"GI": "BAL43359", "sequence": "MKNRDIQKLAERNGLILSDEMSFNEMGIDFKVGFATDRDGTKWLLRIPRRTTLGEQIANEKRILQLVSKYLSVQVPDWRIANEKLVAYPLLDGKPALTYDAETYEVTWNMSKENDLYIPSLAKALIELHSIPTEEVLRNNLKILTPEQVRNEISERLILVKSELGINAELELRYQKWLDNDALWPNFTKFIHGDLYAGHTLTHHNGEVCGIIDWSTAQVSDIAQDFSGHVTVFGEESLKNLIAAYEKQGGEVWDKLFEQAVERAAAAPLAYGYFALETQDEIHLSSAKLQLGVE"}}}}, "ARO_category": {"36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}, "ARO_name": "mphG", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40397", "model_name": "mphG", "model_type_id": "40292"}, "2257": {"model_id": "2257", "ARO_accession": "3003361", "model_param": {"snp": {"param_type": "single resistance variant", "param_value": {"3421": "V295C", "3420": "G279A", "3418": "G261S", "3419": "V278A"}, "clinical": {"3421": "V295C", "3420": "G279A", "3418": "G261S", "3419": "V278A"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A", "model_sequences": {"sequence": {"3512": {"dna_sequence": {"fmax": "1670", "fmin": "476", "accession": "U67308.1", "strand": "+", "sequence": "GTGGCCAAGGCCAAGTTCGAGCGGACCAAGCCGCACATGAACATCGGCACCATTGGGCATATCGACCACGGCAAGACCACTCTGACCGCGGCGATCACCAAGGTGCTCCACGACCGGTACCCCGAGCTGAACAAGGCGACCCCGTTCGACAAGATCGACAAGGCGCCCGAGGAGAAGGCTCGTGGCATCACGATCTCCATCGCGCACGTCGAGTACCAGACCGAGAAGCGCCACTACGCCCACGTGGACTGCCCCGGTCACGCCGACTACGTGAAGAACATGATCACCGGTGCTGCTCAGATGGACGGCGCCATCCTCGTGGTCGCCGCCACCGCCGGCCCGATGCCGCAGACGAAGGAGCACGTCCTCCTGGCCCGTCAGGTCGGCGTCCCCTACATCGTCGTGGCCCTGAACAAGGCCGACATGGTGGACGACGAGGAGATCCTGGAGCTCGTCGAGCTCGAGGTCCGCGAGCTGCTCTCGGCTCAGGAGTTCCCCGGCGACGACCTGCCGGTCGTGCGCGTCTCCGCTCTCAAGGCCCTCGAGGGCGACGAGAAGTGGGCCGACAGCATCATCGAGCTGATGAACGCTGTGGACGAGAACATCCCCGAGCCGCCGCGTGACACCGACAAGCCGTTCCTCATGCCGATCGAGGACGTCTTCTCGATCACCGGTCGTGGAACCGTCGTCACCGGCCGTATCGAGCGCGGTGTCGTCAAGGTCAACGAGCAGGTCGACATCATCGGCATCAAGAGCGAGAAGACCACGACCACCGTCACCAGCATCGAGATGTTCAACAAGATGCTGGACGAGGGCCACGCGGGTGACAACGCGGCCCTGCTGCTCCGCGGCATCAAGCGTGAGCAGGTCGAGCGCGGCCAGTGCATCATCAAGCCGGGCACGACCACCCCGCACACCGAGTTCGAGGCTCAGGTCTACATCCTGTCCAAGGACGAGGGCGGCCGCCACACGCCGTTCTTCAACAACTACCGTCCGCAGTTCTACTTCCGTACGACTGACGTGACCGGTGTCGTGAACCTGCCCGAGGGCACCGAGATGGTCATGCCCGGTGACAACACCGAGATGACCGTCCAGCTCATCCAGCCGATCGCGATGGAGGAAGGCCTCAAGTTCGCGATCCGTGAGGGTGGCCGGACCGTCGGCGCCGGCCGCGTCACCAAGATCCTCAAGTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Planobispora rosea", "NCBI_taxonomy_id": "35762", "NCBI_taxonomy_cvterm_id": "40395"}, "protein_sequence": {"GI": "AAB39605.1", "sequence": "MAKAKFERTKPHMNIGTIGHIDHGKTTLTAAITKVLHDRYPELNKATPFDKIDKAPEEKARGITISIAHVEYQTEKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATAGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEILELVELEVRELLSAQEFPGDDLPVVRVSALKALEGDEKWADSIIELMNAVDENIPEPPRDTDKPFLMPIEDVFSITGRGTVVTGRIERGVVKVNEQVDIIGIKSEKTTTTVTSIEMFNKMLDEGHAGDNAALLLRGIKREQVERGQCIIKPGTTTPHTEFEAQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVNLPEGTEMVMPGDNTEMTVQLIQPIAMEEGLKFAIREGGRTVGAGRVTKILK"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "37710": {"category_aro_name": "elfamycin resistance gene", "category_aro_cvterm_id": "37710", "category_aro_accession": "3001311", "category_aro_description": "Genes conferring resistance to elfamycin antibiotics."}}, "ARO_name": "Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "39945", "model_name": "Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A", "model_type_id": "40293"}, "2252": {"model_id": "2252", "ARO_accession": "3003575", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "The LpxD gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane", "model_sequences": {"sequence": {"3509": {"dna_sequence": {"fmax": "2258022", "fmin": "2256951", "accession": "CP010781.1", "strand": "-", "sequence": "CTATTTACGCAAATTAAAAGTTGATTCAAGAGACTCTATTTGAGCTTGTATATGATCAAGTCGTTTAGTGATTTGGGTCAATGGCACATCTGCTAATTGTCGCAAGCGTACAATCGTCTTTTTCCAATGATTATTTTCAAATAATCCGGTTCCCGAAGAGTAAGTTCCAGCTTCAGAAATATTTTTTGTGACCATTGACATTCCAGTCAAAGTCACATTATCAGCAATTGAAAGGTGTCCTGCCACTCCACACGCCCCAGCTAGAATACAGTTTTTGCCAATTTTTGTACTTCCGGCAATACCGCACTTCGCTGCAATAGCAGTATTTGAACCAATATGGACGTTATGTGCAATTTGCACAAGGTTATCAATAATAACCCCATCTTCCAAAATTGTATTATCAAGTGCGCCTCTATCAATACTACAATTTGATCCAATTCGGACATCATTTCCAATTAAAACTGAACCTAATTGAGCAATACGATGCCACTTTCCTTGATATGGAGCAAAACCAAAACCTTCTCCACCAATGACAGTACTTGAATGAATACGGACGCGATCTCGTAATTTAGAACCACCTGTAATAGTGACATGAGAATCAATAAAACAGTCTTTTCCAACTTCTACATTATCATCAAGTTTGGTATGTGACTGAATGACGGTATTATCGCCAACTACACAATTCTCACCAATAACCACATAGTGACCAATATAAGCAGTTTCGGAAATAACAGCAGATGGATGAATTTGGGCAGTGCTTTCTATGCCTGTTGAGCTAATCTTTTTATCAAATACATGGGTAAGGATTGCAAACGCAAGATAGGGATTATCAACAATAATAAAATTATCTTTTTCAGGAAGATGTTCTTTTAAAGCTGCGGTAACAATGTAAGCGCCCGCACGACTTACTTTAGCTTGATCAAGATGTTTCTCACCATTCACAAAAGTAAGATGGTTAACCTCTGCATTTTCCAAACTCGCCAAGTTTGAAAATTGAAGACTACCTTCACCAATTAGCTCACCTTTAACAAGGTGAGCTAATTCATCTAAACGATATTGTTGCACTTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"GI": "AJF82051.1", "sequence": "MKVQQYRLDELAHLVKGELIGEGSLQFSNLASLENAEVNHLTFVNGEKHLDQAKVSRAGAYIVTAALKEHLPEKDNFIIVDNPYLAFAILTHVFDKKISSTGIESTAQIHPSAVISETAYIGHYVVIGENCVVGDNTVIQSHTKLDDNVEVGKDCFIDSHVTITGGSKLRDRVRIHSSTVIGGEGFGFAPYQGKWHRIAQLGSVLIGNDVRIGSNCSIDRGALDNTILEDGVIIDNLVQIAHNVHIGSNTAIAAKCGIAGSTKIGKNCILAGACGVAGHLSIADNVTLTGMSMVTKNISEAGTYSSGTGLFENNHWKKTIVRLRQLADVPLTQITKRLDHIQAQIESLESTFNLRK"}}}}, "ARO_category": {"39418": {"category_aro_name": "polymyxin resistance gene", "category_aro_cvterm_id": "39418", "category_aro_accession": "3002984", "category_aro_description": "Genes conferring resistance to polymyxins"}, "36021": {"category_aro_name": "gene conferring antibiotic resistance via molecular bypass", "category_aro_cvterm_id": "36021", "category_aro_accession": "3000012", "category_aro_description": "Genes involved in restructuring of the cell wall"}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "LpxD", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40185", "model_name": "LpxD", "model_type_id": "40293"}, "2251": {"model_id": "2251", "ARO_accession": "3003574", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"3342": "P30L"}, "clinical": {"3342": "P30L"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane", "model_sequences": {"sequence": {"3508": {"dna_sequence": {"fmax": "3758934", "fmin": "3758031", "accession": "CP010781.1", "strand": "-", "sequence": "TTATGTCACACTCACGTATGGAATTGGACAGTCTTTCTCGTCATCAAATGTTACAATTTCATAATTACTCGGATCGCTTTGAACATTGCGTAATAGCTGATTATTTAAGGCATGTCCTGATTTATAGCCATCAAACTTGGCAATAATTTGATGACCAAGTAAATACAAATCACCAACTGCATCTAAAATTTTGTGACGAACAAACTCATCGGCAAATCGTAAACCTTCTTCGTTTACAACACCTGTATCATCTACGCCAATTGCATTATCTAGACTTGCTCCTAAAGCTAAATTATTTGCTTTAAGGTAATCCAAGTCTTTCATAAAACCAAAAGTTCGTGCCTCACTGACCTCATACACAAACGTTTCAGTAGAAAAATCGATAGTTGCAGACTGATATTCTTTGGCAAATGCAGGATGATCAAAATCAATCGTAAAGTTAAGCTGAAAGCCATTATGCGGGCTGAATATTGCTTTTTTATCATCAATTAAAGCCTCAACTGGCTTTAATATTTTTATAAATTTCTTAGGAGCATCTTGTTCACGCAAGCCACCTTGCATGAGCAAATAAATAAATGGACCAGCACTACCATCCATAATTGGAACTTCAGAAGCAGACACTTCCACAATTAAGTTATCGATTCCTAAACCGGCAATCGCACTCATCACATGTTCGATTGTCCCGACTTTAATATCGCCAGTAACAAGATTTGAACACATAAATGCTTCTTGAATCAGCAATGCATTAGCAGGAATATCGACAGGTGGATCCAAATCGATACGGCGAAATACAATACCTCCATCCACGGTATGTGGAATGAAATTGATCATCACTTTTTGACCGCTATGAAGACCTATTCCACTCGCTTTTACCACACGATTGAGAGTACGCTGTTTCACCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"GI": "AJF83452.1", "sequence": "MVKQRTLNRVVKASGIGLHSGQKVMINFIPHTVDGGIVFRRIDLDPPVDIPANALLIQEAFMCSNLVTGDIKVGTIEHVMSAIAGLGIDNLIVEVSASEVPIMDGSAGPFIYLLMQGGLREQDAPKKFIKILKPVEALIDDKKAIFSPHNGFQLNFTIDFDHPAFAKEYQSATIDFSTETFVYEVSEARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFADEFVRHKILDAVGDLYLLGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDEKDCPIPYVSVT"}}}}, "ARO_category": {"39418": {"category_aro_name": "polymyxin resistance gene", "category_aro_cvterm_id": "39418", "category_aro_accession": "3002984", "category_aro_description": "Genes conferring resistance to polymyxins"}, "36021": {"category_aro_name": "gene conferring antibiotic resistance via molecular bypass", "category_aro_cvterm_id": "36021", "category_aro_accession": "3000012", "category_aro_description": "Genes involved in restructuring of the cell wall"}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "LpxC", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40184", "model_name": "LpxC", "model_type_id": "40293"}}}