Model_id Action ARO_name ARO_category Changes To Summary 217 UPDATE vanXA glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-130 " 212 UPDATE Staphylococcus aureus parC conferring resistance to fluoroquinolone gene involved in self resistance to antibiotic; antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; ARO_category; model_param "UPDATED category_aro_name with gene involved in self resistance to antibiotic UPDATED category_aro_cvterm_id with 36631 UPDATED category_aro_accession with 3000492 UPDATED category_aro_description with Genes that are involved in conferring self resistance to antibiotic UPDATED 3563 with S80Y UPDATED 3564 with S80F UPDATED 3563 with S80Y UPDATED 2179 with E84G UPDATED 3564 with S80F " 1301 UPDATE Staphylococcus aureus cls conferring resistance to daptomycin antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_param "UPDATED 3440 with T33N UPDATED 622 with A23V UPDATED 687 with L52F UPDATED 653 with F60S UPDATED 3440 with T33N " 1308 UPDATE vanTE glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-160 " 660 UPDATE Streptococcus pneumonia parC conferring resistance to fluoroquinolone gene involved in self resistance to antibiotic; antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; ARO_category; model_param "UPDATED category_aro_name with gene involved in self resistance to antibiotic UPDATED category_aro_cvterm_id with 36631 UPDATED category_aro_accession with 3000492 UPDATED category_aro_description with Genes that are involved in conferring self resistance to antibiotic UPDATED 2183 with D83H UPDATED 2184 with S80W " 2097 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to paromomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2995 with A1408G " 2096 UPDATE Escherichia coli 16S rRNA mutation in the rrsC gene conferring resistance to kasugamicin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2998 with A1519G UPDATED 3034 with G926T UPDATED 2977 with A1519T UPDATED 2979 with A794G UPDATED 3050 with G926A UPDATED 2971 with A794T UPDATED 2951 with A1519C UPDATED 2941 with G926C " 2091 UPDATE Mycobacterium chelonae 16S rRNA mutation conferring resistance to gentamicin C antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3008 with A1355G " 2090 UPDATE Mycobacterium abscessus 16S rRNA mutation conferring resistance to kanamycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2912 with T1373A UPDATED 2922 with C1376T UPDATED 2915 with G1458T UPDATED 3075 with A1375G " 2093 UPDATE Chlamydophila psittaci 16S rRNA mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3027 with C1193G UPDATED 2932 with G1194C UPDATED 3010 with A1192G UPDATED 2914 with C1193T " 2092 UPDATE Enterobacter aerogenes acrR mutation resulting in antibiotic resistance chloramphenicol resistance gene; gene modulating antibiotic efflux; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; model_param "UPDATED 2992 with R45C " 336 UPDATE tlrB antibiotic target modifying enzyme; gene involved in self resistance to antibiotic; macrolide resistance gene; model_param; ARO_name "UPDATED param_value with 1e-120 UPDATED ARO_name with tlrB conferring tylosin resistance " 2099 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsB gene conferring resistance to kanamycin A antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3029 with A1391G UPDATED 2916 with T1389A " 2098 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsB gene conferring resistance to viomycin peptide antibiotic resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 3053 with G1475T UPDATED 2985 with G1475A " 1547 UPDATE vanRC glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 691 UPDATE vanRE glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1835 UPDATE tet38 efflux pump conferring antibiotic resistance; tetracycline resistance gene; model_param "UPDATED param_value with 1e-100 " 2105 UPDATE Mycobacterium abscessus 16S rRNA mutation conferring resistance to neomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2896 with A1375G " 1943 UPDATE Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid antibiotic resistant gene variant or mutant; isoniazid resistance gene; model_param "UPDATED 2569 with F413L UPDATED 2568 with G387D UPDATED 2567 with R121K " 29 UPDATE Escherichia coli sulfonamide resistant mutant folP antibiotic resistant gene variant or mutant; sulfonamide resistance gene; model_param "UPDATED 2281 with P64S UPDATED 2282 with P64A UPDATED 2283 with P64H UPDATED 2114 with P64R UPDATED 2115 with P64L " 2154 UPDATE Borrelia burgdorferi 16S rRNA mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2996 with C1185T UPDATED 2975 with A1184G " 2155 UPDATE Propionibacterium acnes 16S rRNA mutation conferring resistance to tetracycline antibiotic resistant gene variant or mutant; tetracycline resistance gene; model_param "UPDATED 2931 with G1032C " 2157 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to gentamicin C antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3018 with A1408G UPDATED 2974 with T1406A " 2152 UPDATE Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2897 with G1065C " 810 UPDATE mecC antibiotic resistance gene cluster, cassette, or operon; antibiotic inactivation enzyme; beta-lactam resistance gene; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 2246 UPDATE vanRI glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 349 UPDATE vanL glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 409 UPDATE vanRL glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 570 UPDATE Streptococcus pyogenes sulfonamide resistant folP mutants antibiotic resistant gene variant or mutant; sulfonamide resistance gene; model_param "UPDATED 2116 with F25I " 1441 UPDATE Enterobacter aerogenes omp36 mutants antibiotic resistant gene variant or mutant; beta-lactam resistance gene; gene modulating permeability to antibiotic; model_param "UPDATED 2085 with G133D " 1622 UPDATE vanWG glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1157 UPDATE vanG glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-120 " 1790 UPDATE vanHF glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-180 " 1098 UPDATE vanB glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-180 " 366 UPDATE Mycobacterium tuberculosis iniA mutant conferring resistance to Ethambutol efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; ethambutol resistance gene; model_param "UPDATED 3333 with S501W UPDATED 3334 with G308R UPDATED 3333 with S501W UPDATED 3334 with G308R " 1956 UPDATE IMI-1 antibiotic inactivation enzyme; beta-lactam resistance gene; model_param "UPDATED param_value with 1e-160 " 264 UPDATE lsaE lincosamide resistance gene; pleuromutilin resistance gene; ARO_category "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin " 2070 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2980 with A1401G " 1554 UPDATE norA efflux pump conferring antibiotic resistance; fluoroquinolone resistance gene; model_param "UPDATED param_value with 1e-100 " 1558 UPDATE Bacillus subtilis mprF mutations conferring resistance to daptomycin antibiotic target modifying enzyme; peptide antibiotic resistance gene; ARO_name; ARO_description; ARO_category; model_param; model_type; model_description; model_name; model_type_id "UPDATED ARO_name with Bacillus subtilis mprF UPDATED ARO_description with MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Additionally, large-scale mutations causing loss of function of the gene result in increased susceptibility to daptomycin. UPDATED category_aro_name with antibiotic target modifying enzyme UPDATED category_aro_cvterm_id with 36658 UPDATED category_aro_accession with 3000519 UPDATED category_aro_description with Enzymes that confer resistance by modifying antibiotic targets. UPDATED category_aro_name with peptide antibiotic resistance gene UPDATED category_aro_cvterm_id with 37131 UPDATED category_aro_accession with 3000751 UPDATED category_aro_description with Genes conferring resistance to peptide antibiotics. DELETED snp UPDATED model_type with protein homolog model UPDATED model_description with Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off. UPDATED model_name with Bacillus subtilis mprF UPDATED model_type_id with 40292 " 1826 UPDATE ykkC efflux pump conferring antibiotic resistance; chloramphenicol resistance gene; tetracycline resistance gene; model_param "UPDATED param_value with 1e-60 " 1822 UPDATE Staphylococcus aureus gyrB conferring resistance to aminocoumarin aminocoumarin resistance gene; antibiotic resistant gene variant or mutant; model_param "DELETED 2141 UPDATED 3442 with G85S UPDATED 3442 with G85S UPDATED 2147 with T173A UPDATED 2146 with I102S UPDATED 2145 with I56S UPDATED 2144 with R144I UPDATED 2143 with R144S UPDATED 2142 with S128L " 2068 UPDATE Escherichia coli 16S rRNA mutation conferring resistance to edeine peptide antibiotic resistance gene; antibiotic resistant gene variant or mutant; polyamine resistance gene; model_param "UPDATED 2928 with T1506A UPDATED 3073 with A1499G " 2146 UPDATE Escherichia coli 16S rRNA mutation in the rrnB gene conferring resistance to streptomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3066 with G527T UPDATED 3032 with C528T " 535 UPDATE Morganella morganii gyrB conferring resistance to fluoroquinolone antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 3448 with S463A UPDATED 2164 with S464Y UPDATED 3448 with S463A " 2144 UPDATE Mycobacterium bovis embB mutations conferring resistance to ethambutol ethambutol resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2969 with Q998R UPDATED 2950 with T610K UPDATED 2917 with F1012S " 2143 UPDATE Borrelia burgdorferi 16S rRNA mutation conferring resistance to gentamicin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3038 with A1401G " 2142 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsA gene conferring resistance to viomycin peptide antibiotic resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 3069 with G1475A UPDATED 3001 with G1475T " 2141 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsB gene conferring resistance to neomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2893 with T1389A " 2140 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to streptomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2966 with A523C " 824 UPDATE vanD glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-180 " 372 UPDATE qacA efflux pump conferring antibiotic resistance; fluoroquinolone resistance gene; model_param "UPDATED param_value with 1e-100 " 821 UPDATE Mycobacterium tuberculosis embB mutants conferring resistance to rifampicin rifampin resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2649 with Y319D UPDATED 2650 with Y333H " 2066 UPDATE Escherichia coli soxS mutant chloramphenicol resistance gene; gene modulating antibiotic efflux; gene modulating permeability to antibiotic; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; model_param "UPDATED 3562 with A12S UPDATED 3562 with A12S UPDATED param_type with single resistance variant UPDATED param_type_id with 36301 UPDATED param_description with A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s). " 1383 UPDATE IMI-4 antibiotic inactivation enzyme; beta-lactam resistance gene; model_param "UPDATED param_value with 1e-160 " 1323 UPDATE Salmonella serovars parE conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 2227 with V461G " 1320 UPDATE Klebsiella mutant PhoP conferring antibiotic resistance to colistin gene modulating antibiotic efflux; gene altering cell wall charge conferring antibiotic resistance; macrolide resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; polymyxin resistance gene; model_sequences; model_param "UPDATED fmax with 2326308 UPDATED strand with - UPDATED accession with FO834906.1 UPDATED fmin with 2325636 UPDATED sequence with TCAGCGCAATTCGAACAGATAGCCCTGGCCGCGCACCGTGGTGATGACGTCCTGTGGGTATTCAGCCTGAATTTTCTTGCGCAGCCGACCCATCAGCACGTCGATGGTGTGGCTTTCTCGCAGTTCGGCATCCGGGTAAAGCTGGAGCATCAGCGAATCTTTGCTGACCACTTTGCCGCGGTTACGGATCAGGGTTTCCATAATGGTGTATTCAAAGGCGGTCAGCTTGATCGGCTGGTCATTCACCGACAGCTCGCGCCGGGAGAGGTCGACCTGGAACGGCGGCAGGGAGATCACCTGCGAGGCCAGACCGCTGTTACGGCGCAGCAGCGCCTGCATGCGGGCGGCAACCTCTTCAATATGGAAAGGCTTGGTGACGTAATCATCCGCCCCGGCGCTCAGCACTTCCACTTTATCCTGCCATCCTTCGCGGGCGGTCAGCACCAGCACCGGCAGCGACACGTCGTGGCTGCGCCAGCGGCGGATCAGTGATAAACCGTCTTCATCCGGCAGGCCGAGATCGACGATGGCGATATCCGGGAGATGTTCGCCCAGATAGTAGTCCGCTTCCCTGGCATCTTCCGCCGCATCGACCTGATGGCCCAGCTCCTGCAGCTGAACTTTGAGGTGGTGACGCAGCAGGGCATTATCCTCAACCACGAGTACGCGCAT UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED GI with CDO13981.1 UPDATED sequence with MRVLVVEDNALLRHHLKVQLQELGHQVDAAEDAREADYYLGEHLPDIAIVDLGLPDEDGLSLIRRWRSHDVSLPVLVLTAREGWQDKVEVLSAGADDYVTKPFHIEEVAARMQALLRRNSGLASQVISLPPFQVDLSRRELSVNDQPIKLTAFEYTIMETLIRNRGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAEYPQDVITTVRGQGYLFELR UPDATED 2871 with D191Y " 1321 UPDATE mecA antibiotic resistance gene cluster, cassette, or operon; antibiotic inactivation enzyme; beta-lactam resistance gene; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 597 UPDATE Klebsiella pneumoniae ramR mutants chloramphenicol resistance gene; gene modulating antibiotic efflux; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; model_param "UPDATED 2134 with A16D UPDATED 2135 with I88N UPDATED 2863 with G96D UPDATED 2110 with K5E UPDATED 2111 with T43M UPDATED 2112 with T162I UPDATED 2113 with A19V " 1120 UPDATE IMI-7 antibiotic inactivation enzyme; beta-lactam resistance gene; model_param "UPDATED param_value with 1e-160 " 2113 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to tobramycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2899 with T1406A " 1328 UPDATE vanSM glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 196 UPDATE Mycobacterium tuberculosis embB mutations conferring resistance to ethambutol ethambutol resistance gene; antibiotic resistant gene variant or mutant; model_param "DELETED 2477 UPDATED 3593 with Y319C UPDATED 3590 with D331Y UPDATED 3596 with T630I UPDATED 3595 with Y319N UPDATED 3594 with Y333C UPDATED 3588 with E504Q UPDATED 3589 with R507G UPDATED 3593 with Y319C UPDATED 2299 with M306V UPDATED 2298 with M306L UPDATED 2472 with G406D UPDATED 2471 with G406C UPDATED 2470 with G406S UPDATED 2431 with A357S UPDATED 2430 with A356V UPDATED 2297 with D299E UPDATED 2296 with S297A UPDATED 2453 with S380R UPDATED 2478 with P446H UPDATED 3590 with D331Y UPDATED 2460 with P397Q UPDATED 3596 with T630I UPDATED 2345 with D311H UPDATED 3595 with Y319N UPDATED 2488 with Q497R UPDATED 2489 with Q497K UPDATED 2301 with M306T UPDATED 2300 with M306I UPDATED 2485 with I465D UPDATED 2482 with R460C UPDATED 2240 with F330V UPDATED 2242 with G406A UPDATED 2243 with L413P UPDATED 2464 with N399H UPDATED 2440 with E368A UPDATED 2446 with P375A UPDATED 3588 with E504Q UPDATED 3589 with R507G UPDATED 2426 with Y334H UPDATED 2450 with E378A UPDATED 2239 with D328G UPDATED 2238 with D328Y UPDATED 2491 with D959A UPDATED 2490 with G745D UPDATED 2493 with D1024N UPDATED 2492 with M1000R UPDATED 3594 with Y333C UPDATED 2486 with R469P UPDATED 2413 with L239P UPDATED 2414 with D240H UPDATED 2487 with R471P " 984 UPDATE Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 3416 with D95N UPDATED 3415 with D90G UPDATED 2121 with D90G UPDATED 2122 with D95N UPDATED 3416 with D95N UPDATED 3415 with D90G " 1088 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to daptomycin antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_param "UPDATED 2047 with I953S UPDATED 2048 with A1085V UPDATED 2049 with A621E " 1920 UPDATE vanSF glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 117 UPDATE elfamycin resistant EF-Tu antibiotic resistant gene variant or mutant; elfamycin resistance gene; model_param "UPDATED 146 with E378K UPDATED 147 with R230C UPDATED 144 with A375S UPDATED 145 with A375V UPDATED 142 with Q329H UPDATED 143 with A375T UPDATED 140 with Y160C UPDATED 141 with G316D UPDATED 150 with T334A UPDATED 151 with R230V UPDATED 153 with G257A UPDATED 148 with R233S UPDATED 149 with R333C UPDATED 152 with R233F UPDATED 137 with Q124K UPDATED 136 with Q124E UPDATED 135 with Q124R UPDATED 134 with L120Q UPDATED 139 with Y160D UPDATED 138 with Y160N UPDATED 154 with G275A " 390 UPDATE vanSG glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1924 UPDATE vanM glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-170 " 1925 UPDATE mexB chloramphenicol resistance gene; beta-lactam resistance gene; macrolide resistance gene; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; aminocoumarin resistance gene; tetracycline resistance gene; polymyxin resistance gene; trimethoprim resistance gene; model_param "UPDATED param_value with 1e-160 " 276 UPDATE tetR efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; gene modulating antibiotic efflux; model_param "UPDATED 2712 with T103I UPDATED 2710 with H64Y UPDATED 2711 with N82H " 2147 UPDATE Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa antibiotic resistant gene variant or mutant; elfamycin resistance gene; model_param "UPDATED 3568 with Q124K UPDATED 3569 with Q329H UPDATED 3566 with A375T UPDATED 3567 with G316D UPDATED 3568 with Q124K UPDATED 3569 with Q329H UPDATED 3566 with A375T UPDATED 3567 with G316D " 1710 UPDATE Mycobacterium leprae gyrB conferring resistance to fluoroquinolone antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_sequences; model_param "DELETED 2065 DELETED 2167 UPDATED 2165 with D464N UPDATED 2172 with E504V UPDATED 2169 with N502D " 794 UPDATE Staphylococcus aureus rpoC conferring resistance to daptomycin antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_param "UPDATED 2071 with Q961K UPDATED 2070 with F632S " 2069 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to neomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3060 with A1408G " 2145 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to tetracycline antibiotic resistant gene variant or mutant; tetracycline resistance gene; model_param "UPDATED 3061 with G1058C " 798 UPDATE cmeC efflux pump conferring antibiotic resistance; macrolide resistance gene; beta-lactam resistance gene; antibiotic inactivation enzyme; fluoroquinolone resistance gene; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 3 UPDATE Escherichia coli ompF mutants antibiotic resistant gene variant or mutant; beta-lactam resistance gene; gene modulating permeability to antibiotic; model_param "UPDATED 2256 with R154D UPDATED 2255 with R154A UPDATED 2254 with G141E UPDATED 2253 with G141D " 2078 UPDATE Mycobacterium chelonae 16S rRNA mutation conferring resistance to kanamycin A antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3074 with A1355G " 2073 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to G418 antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2898 with T1406A " 1748 UPDATE lsaC efflux pump conferring antibiotic resistance; streptogramin resistance gene; lincosamide resistance gene; pleuromutilin resistance gene; ARO_category "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin " 1395 UPDATE Neisseria gonorrhoeae mutant porin PIB (por) with reduced permeability to antibiotic beta-lactam resistance gene; antibiotic resistant gene variant or mutant; tetracycline resistance gene; gene modulating permeability to antibiotic; model_sequences; model_param "DELETED 55 UPDATED 60 with G120K UPDATED 61 with G120D UPDATED 64 with A121D DELETED 40330 " 2077 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsA gene conferring resistance to neomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2990 with T1389A " 2076 UPDATE Neisseria gonorrhoeae 16S rRNA mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3004 with C1192T " 2074 UPDATE Salmonella enterica serovar Typhimurium 16S rRNA mutation in the rrsD gene conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3035 with C1065T UPDATED 3015 with C1192T " 1237 UPDATE Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin rifampin resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 3276 with H451C UPDATED 3277 with H451D UPDATED 3274 with S447Q UPDATED 3275 with H451Y UPDATED 3272 with D441V UPDATED 3273 with D441Y UPDATED 3270 with V176F UPDATED 3271 with Q438K UPDATED 3278 with H451R UPDATED 3279 with S456L UPDATED 3258 with S531W UPDATED 3259 with S531G UPDATED 3251 with S531L UPDATED 3252 with H526C UPDATED 3253 with L533R UPDATED 3254 with L538R UPDATED 3255 with H526Y UPDATED 3256 with D516V UPDATED 3257 with L533P UPDATED 3261 with H526S UPDATED 3260 with H526D UPDATED 3263 with D516T UPDATED 3262 with K527Q UPDATED 3265 with M515I UPDATED 3264 with D516Y UPDATED 3267 with L511P UPDATED 3266 with M515V UPDATED 3269 with S522L UPDATED 3268 with I572F UPDATED 3280 with S456W " 1339 UPDATE Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol ethambutol resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2350 with C110Y UPDATED 2369 with Q379R " 1669 UPDATE vanZF glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-130 " 1232 UPDATE cmeR antibiotic inactivation enzyme; gene modulating antibiotic efflux; macrolide resistance gene; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; beta-lactam resistance gene; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 2127 UPDATE Borrelia burgdorferi 16S rRNA mutation conferring resistance to kanamycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3012 with A1401G " 440 UPDATE mexA chloramphenicol resistance gene; beta-lactam resistance gene; macrolide resistance gene; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; aminocoumarin resistance gene; tetracycline resistance gene; polymyxin resistance gene; trimethoprim resistance gene; model_param "UPDATED param_value with 1e-140 " 953 UPDATE Enterococcus faecium liaF mutant conferring daptomycin resistance peptide antibiotic resistance gene; antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_param "UPDATED 21 with I144T UPDATED 721 with L39F " 1135 UPDATE Staphylococcus aureus parE conferring resistance to aminocoumarin aminocoumarin resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2192 with D78S UPDATED 2193 with R136G " 1545 UPDATE Escherichia coli gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 3318 with S83W UPDATED 3326 with S83L UPDATED 3327 with D87V UPDATED 2051 with D87N UPDATED 2050 with S83I UPDATED 2053 with D87H UPDATED 2052 with D87G UPDATED 2084 with D87Y UPDATED 3318 with S83W UPDATED 3326 with S83L UPDATED 3327 with D87V " 240 UPDATE vanRF glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1935 UPDATE Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "DELETED 2182 UPDATED 2217 with D94V UPDATED 2216 with D94Y UPDATED 2095 with D89G UPDATED 2094 with D89N UPDATED 2181 with D94N UPDATED 2096 with G88C UPDATED 2091 with D94G UPDATED 2093 with D94A UPDATED 2092 with D89V UPDATED 2180 with S91P UPDATED 2504 with A90G UPDATED 2503 with A90V UPDATED 2502 with G88A " 1666 UPDATE vanXB glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 100 UPDATE mycobacterium tuberculosis ethA mutant conferring resistance to ethionamide antibiotic resistant gene variant or mutant; model_param "UPDATED 2499 with G413D UPDATED 2498 with T392A UPDATED 2495 with E223K UPDATED 2494 with G43S UPDATED 2497 with G385D UPDATED 2496 with I338S UPDATED 2500 with R463S " 851 UPDATE Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide antibiotic resistant gene variant or mutant; pyrazinamide resistance gene; model_param "DELETED 2594 UPDATED 3427 with P54T UPDATED 3426 with A140S UPDATED 3434 with G17D UPDATED 3435 with Y34S UPDATED 3425 with T47A UPDATED 3424 with D12E UPDATED 2614 with N118T UPDATED 2623 with C138Y UPDATED 3427 with P54T UPDATED 3426 with A140S UPDATED 2598 with P69R UPDATED 2630 with T142M UPDATED 2618 with G132S UPDATED 2621 with H137P UPDATED 3434 with G17D UPDATED 3435 with Y34S UPDATED 2605 with L85P UPDATED 2584 with Y41H UPDATED 2582 with A26G UPDATED 2602 with C72R UPDATED 2625 with V139L UPDATED 2629 with T142K UPDATED 2608 with K96N UPDATED 2576 with Q10P UPDATED 2575 with Q10R UPDATED 2572 with I5S UPDATED 2573 with V7G UPDATED 3425 with T47A UPDATED 3424 with D12E " 1849 UPDATE Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides antibiotic target modifying enzyme; antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2235 with N236K UPDATED 2259 with P183L UPDATED 2258 with L118P UPDATED 2257 with R14W UPDATED 2189 with L150P UPDATED 2188 with A91E " 1432 UPDATE Mycobacterium tuberculosis mutant embC conferring resistance to ethambutol ethambutol resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 3612 with R738Q UPDATED 3612 with R738Q UPDATED 2392 with Y327N UPDATED 3290 with S244T UPDATED 2381 with I297L UPDATED 2380 with Y296S UPDATED 2383 with M300R UPDATED 2382 with I297T UPDATED 2385 with V303G UPDATED 2384 with R302G UPDATED 2387 with G308D UPDATED 2386 with A307T UPDATED 2389 with M310K UPDATED 2263 with Q491R UPDATED 2261 with T270I UPDATED 2264 with L502P UPDATED 2393 with N394D UPDATED 2262 with P398S UPDATED 2388 with Y309N UPDATED 2394 with V981L UPDATED 2378 with G288V UPDATED 2379 with Y296H UPDATED 2390 with G325S UPDATED 2391 with W326R UPDATED 2375 with H285Y UPDATED 2376 with V287F UPDATED 2377 with G288W UPDATED 2371 with A247P UPDATED 2372 with L251R UPDATED 2373 with A254G " 1842 UPDATE IMI-3 antibiotic inactivation enzyme; beta-lactam resistance gene; model_param "UPDATED param_value with 1e-160 " 1724 UPDATE vanHM glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-180 " _version N/A N/A N/A N/A NEW: 1.0.7 , OLD: 1 1721 UPDATE Mycobacterium leprae dapsone resistant folP mutants antibiotic resistant gene variant or mutant; sulfonamide resistance gene; model_param "DELETED 2194 UPDATED 3294 with P55T UPDATED 3295 with P55A UPDATED 3296 with P55H UPDATED 3292 with T53P UPDATED 3293 with T53N UPDATED 2200 with P55R UPDATED 2201 with P55L UPDATED 2202 with P55S UPDATED 2175 with T53I UPDATED 2140 with T53A UPDATED 3294 with P55T UPDATED 3295 with P55A UPDATED 3296 with P55H UPDATED 3292 with T53P UPDATED 3293 with T53N " 1333 UPDATE vanHD glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 518 UPDATE vanXYN glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 645 UPDATE mecR1 antibiotic resistance gene cluster, cassette, or operon; antibiotic inactivation enzyme; beta-lactam resistance gene; gene modulating beta-lactam resistance; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 377 UPDATE mepA efflux pump conferring antibiotic resistance; tetracycline resistance gene; model_param "UPDATED param_value with 1e-100 " 2102 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsB gene conferring resistance to hygromycin B antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2936 with T1482C UPDATED 2954 with T1389C UPDATED 3037 with C1480T " 1005 UPDATE Escherichia coli soxR mutants chloramphenicol resistance gene; gene modulating antibiotic efflux; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; model_param "UPDATED 2231 with T38S UPDATED 2230 with R20H UPDATED 2233 with G121D UPDATED 2232 with G74R " 1004 UPDATE vanRD glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 432 UPDATE sav1866 efflux pump conferring antibiotic resistance; model_param "UPDATED param_value with 1e-150 " 1001 UPDATE Staphylococcus aureus mprF mutations conferring resistance to daptomycin peptide antibiotic resistance gene; antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_sequences; ARO_category; model_param "UPDATED fmax with 2511 UPDATED strand with + UPDATED accession with HM140977 UPDATED fmin with 0 UPDATED sequence with ATGAATCAGGAAGTTAAAAACAAAATATTTTCAATCTTAAAAATTACGTTTGCTACAGCTTTATTTATTTTTGTAGCAATCACATTGTATCGGGAGTTATCTGGTATTAACTTTAAAGATACGTTGGTTGAATTTAGTAAGATTAACCGTATGTCCTTAGTGTTACTATTTATTGGTGGTGGGGCATCGCTTGTTATTCTATCAATGTATGATGTGATTTTATCTAGAGCTTTAAAAATGGATATATCCTTAGGCAAAGTTTTAAGAGTAAGTTATATCATCAATGCATTGAATGCGATTGTAGGTTTCGGTGGCTTTATTGGTGCAGGCGTTAGAGCAATGGTTTATAAAAACTATACGCATGATAAAAAGAAATTAGTTCACTTTATATCCTTAATACTTATTTCAATGTTGACAGGTTTAAGCTTATTATCATTGCTAATTGTATTCCATGTTTTCGATGCATCTTTAATCTTAGATAAGATTACATGGGTAAGATGGGTATTATATGTAGTGTCATTTTTCTTACCATTATTCATTATTTATTCAATGGTTAGACCACCCGATAAAAACAATCGTTTTGTAGGATTGTACTGCACTTTAGTGTCGTGTGTTGAATGGTTAGCAGCTGCAGTTGTATTATATTTCTGTGGTGTAATTGTTGACGCTCATGTATCATTCATGTCCTTTATTGCAATATTTATCATTGCTGCATTATCAGGTTTAGTCAGCTTTATTCCTGGTGGTTTCGGCGCTTTCGATTTAGTTGTATTACTAGGATTTAAAACTTTAGGTGTCCCTGAGGAAAAAGTATTATTAATGCTACTTCTATATCGTTTTGCGTACTATTTTGTACCGGTAATTATTGCATTAATTTTATCATCATTTGAATTTGGTACATCAGCTAAGAAGTACATTGAGGGATCTAAATACTTTATTCCTGCTAAAGATGTTACGTCATTTTTAATGTCTTATCAAAAGGATATTATTGCTAAAATTCCATCATTATCATTAGCAATTTTAGTATTCTTTACAAGTATGATCAACTTAACGATTGTTTACGATGCTTTATATGATGGAAATCACTTAACGTATTATATTCTATTGGCAATTCATACTAGTGCTTGTTTATTACTTTTACTGAATGTAGTTGGTATTTATAAGCAAAGTAGACGTGCCATTATCTTTGCTATGATTTCAATTTTATTAATCACAGTGGCGACATTCTTCACTTACGCTTCATATATTTTAATAACATGGTTAGCTATTATTTTTGTTCTGCTTATTGTAGCTTTCCGTAGAGCACGTAGGTTGAAACGCCCAGTAAGAATGAGAAATATAGTTGCAATGCTTTTATTCAGTTTATTTATTTTATATGTTAACCATATATTTATTGCTGGAACGTTATATGCATTAGATATTTATACGATTGAAATGCATACATCTGTATTGCGCTATTACTTCTGGCTTACGATTTTAATCATCGCTATCATCATAGGTATGATTGCATGGTTGTTTGATTATCAATTTAGCAAAGTACGTATTTCTTCTAAAATTGAAGATTGCGAGGAGATTATTAATCAGTACGGCGGTAATTATTTGAGTCACTTGATATATAGTGGTGACAAGCAGTTTTTCACTAATGAAAATAAAACAGCATTTTTAATGTATCGTTATAAAGCAAGTTCATTAGTGGTTCTTGGAGATCCGTTAGGTGATGAAAATGCCTTTGATGAATTGTTAGAAGCATTCTATAATTACGCTGAGTATTTAGGCTATGATGTTATATTCTATCAAGTTACAGATCAACACATGCCTTTATATCATAATTTCGGTAACCAATTTTTCAAATTAGGTGAAGAAGCAATTATTGATTTAACGCAATTTTCAACTTCAGGTAAAAAACGCCGTGGATTTAGAGCGACTTTAAATAAATTCGATGAACTTAATATTTCGTTCGAAATTATTGAACCACCGTTTTCAACTGAATTTATAAATGAACTTCAACATGTAAGTGATTTATGGCTAGATAATCGTCAGGAAATGCATTTCTCTGTTGGTGAATTTAATGAAGAATACTTATCTAAAGCGCCAATTGGTGTAATGCGAAATGAAGAAAATGAAGTAATTGCATTTTGTAGTTTAATGCCAACATACTTTAATGATGCCATTTCAGTCGATTTAATTAGATGGTTGCCAGAGTTAGATTTACCATTAATGGATGGTCTATACTTGCATATGTTACTTTGGAGTAAAGAACAAGGTTATACAAAATTTAATATGGGTATGGCAACGTTATCGAACGTTGGTCAATTGCATTATTCATATTTAAGAGAACGACTTGCAGGCCGTGTCTTTGAACATTTCAACGGTCTATATCGTTTCCAAGGATTACGTCGTTATAAATCTAAATATAATCCGAATTGGGAACCACGCTTTTTAGTTTATCGTAAAGATAATTCGCTTTGGGAATCACTTTCTAAAGTAATGCGTGTAATACGTCACAAATAA UPDATED NCBI_taxonomy_name with Staphylococcus aureus UPDATED NCBI_taxonomy_id with 1280 UPDATED NCBI_taxonomy_cvterm_id with 35508 UPDATED GI with ADJ67256 UPDATED sequence with MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGGGASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYTHDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFIIYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALSGLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGTSAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMINLTIVYDALYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYILITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYTIEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSHLIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVIFYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEIIEPPFSTEFINELQHVSDLWLDNRQEMHFSVGEFNEEYLSKAPIGVMRNEENEVIAFCSLMPTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSYLRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK UPDATED category_aro_name with peptide antibiotic resistance gene UPDATED category_aro_cvterm_id with 37131 UPDATED category_aro_accession with 3000751 UPDATED category_aro_description with Genes conferring resistance to peptide antibiotics. UPDATED 3613 with T345K UPDATED 3614 with T472K UPDATED 3615 with M347R UPDATED 3616 with L341S UPDATED 3617 with V351E UPDATED 3609 with I420N UPDATED 2212 with T345A UPDATED 2211 with T345I UPDATED 2210 with P314L UPDATED 2204 with F57S UPDATED 2205 with I418N UPDATED 3616 with L341S UPDATED 2207 with G61V UPDATED 2208 with S337L UPDATED 2206 with S295L UPDATED 3609 with I420N UPDATED 3617 with V351E UPDATED 3613 with T345K UPDATED 2209 with L826F UPDATED 3614 with T472K UPDATED 3615 with M347R " 431 UPDATE Escherichia coli marR mutant resulting in antibiotic resistance chloramphenicol resistance gene; gene modulating antibiotic efflux; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; model_param "UPDATED 2132 with R77L UPDATED 2133 with V96E UPDATED 2130 with I49S UPDATED 2131 with A70T UPDATED 2852 with R94H UPDATED 2109 with G103S UPDATED 2108 with R77C UPDATED 2103 with R94S UPDATED 2102 with Y137H UPDATED 2107 with R73S UPDATED 2106 with R73C UPDATED 2105 with V45E UPDATED 2104 with L78M " 579 UPDATE vgaA efflux pump conferring antibiotic resistance; streptogramin resistance gene; pleuromutilin resistance gene; ARO_category "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin " 1197 UPDATE Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED param_value with 1e-70 DELETED 2659 UPDATED 2653 with K43R UPDATED 2651 with T40I UPDATED 2045 with K88Q UPDATED 2661 with K88R " 627 UPDATE Escherichia coli rpoB mutants conferring resistance to rifampicin rifampin resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2024 with Q513L UPDATED 2025 with Q513P UPDATED 2026 with H526Y UPDATED 2034 with R687H UPDATED 2033 with V146F UPDATED 2032 with P564L UPDATED 2031 with T563P UPDATED 2030 with L533P UPDATED 2027 with R529C UPDATED 2028 with R529S UPDATED 2029 with S531F " 626 UPDATE vanHB glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-170 " 624 UPDATE Mycobacterium leprae rpoB mutants conferring resistance to rifampicin rifampin resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2040 with V472I UPDATED 2041 with S456L " 335 UPDATE Staphylococcus aureus parE conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 2827 with P587S UPDATED 2828 with D434H UPDATED 2829 with D434N " 453 UPDATE mtrE efflux pump conferring antibiotic resistance; model_param "UPDATED param_value with 1e-120 " 499 UPDATE vanSB glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 455 UPDATE vanC glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 259 UPDATE PBP1b antibiotic inactivation enzyme; beta-lactam resistance gene; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 1872 UPDATE vanXYL glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-130 " 2196 UPDATE Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 3143 with T83I UPDATED 3144 with H80R UPDATED 3145 with D87N " 178 UPDATE vanHA glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-180 " 2198 UPDATE Pseudomonas aeruginosa parE conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 3149 with M437I UPDATED 3150 with A473V " 1907 UPDATE vanSA glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1161 UPDATE lsaB efflux pump conferring antibiotic resistance; streptogramin resistance gene; lincosamide resistance gene; pleuromutilin resistance gene; ARO_category "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin " 2201 UPDATE PvrR aminoglycoside resistance gene; gene conferring resistance via absence; ARO_description; model_type; ARO_category; model_type_id; model_description "UPDATED ARO_description with PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence UPDATED model_type with absent protein homolog model UPDATED category_aro_name with aminoglycoside resistance gene UPDATED category_aro_cvterm_id with 36243 UPDATED category_aro_accession with 3000104 UPDATED category_aro_description with Genes conferring resistance to aminoglycoside antibiotics. UPDATED category_aro_name with gene conferring resistance via absence UPDATED category_aro_cvterm_id with 40439 UPDATED category_aro_accession with 3003768 UPDATED category_aro_description with Deletion of gene or gene product results in resistance. For example, deletion of a porin gene blocks drug from entering the cell. UPDATED model_type_id with 40354 UPDATED model_description with A model to detect the absence of a protein that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences and a curated BLASTP cut-off. " 2128 UPDATE Mycobacterium abscessus 16S rRNA mutation conferring resistance to gentamicin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2983 with C1376T UPDATED 3005 with T1373A UPDATED 2958 with A1375G UPDATED 3002 with G1458T " 1983 UPDATE vanTN glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 1981 UPDATE vanA glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-180 " 1731 UPDATE mphB macrolide resistance gene; antibiotic inactivation enzyme; model_sequences "DELETED 638 " 1989 UPDATE Klebsiella pneumoniae acrR mutant resulting in high level antibiotic resistance chloramphenicol resistance gene; gene modulating antibiotic efflux; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; model_param "UPDATED 2128 with Y114F UPDATED 2185 with M109I UPDATED 2867 with V165I " 748 UPDATE cmeB efflux pump conferring antibiotic resistance; macrolide resistance gene; beta-lactam resistance gene; antibiotic inactivation enzyme; fluoroquinolone resistance gene; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 320 UPDATE PBP2x antibiotic inactivation enzyme; beta-lactam resistance gene; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 734 UPDATE vanTC glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 2111 UPDATE Mycobacterium chelonae 16S rRNA mutation conferring resistance to tobramycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2901 with A1355G " 505 UPDATE Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; ethambutol resistance gene; model_param "UPDATED 2346 with P248A " 1036 UPDATE vanWB glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-100 " 2149 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsA gene conferring resistance to hygromycin B antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3016 with T1389C UPDATED 2907 with T1482C UPDATED 3062 with C1480T " 2116 UPDATE Pasteurella multocida 16S rRNA mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3059 with C1194G " 1035 UPDATE PBP2b antibiotic inactivation enzyme; beta-lactam resistance gene; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 752 UPDATE vanRM glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1210 UPDATE novA efflux pump conferring antibiotic resistance; aminocoumarin resistance gene; model_param "UPDATED param_value with 1e-130 " 756 UPDATE Enterococcus faecium liaR mutant conferring daptomycin resistance peptide antibiotic resistance gene; antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_param "UPDATED 22 with W73C " 465 UPDATE vanSO glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1219 UPDATE vanRN glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 786 UPDATE vanHO glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 462 UPDATE Staphylococcus aureus pgsA mutations conferring resistance to daptomycin antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_sequences; model_param "UPDATED fmax with 1279164 UPDATED strand with + UPDATED accession with NC_003923 UPDATED fmin with 1278585 UPDATED sequence with ATGAATATTCCGAACCAGATTACGGTTTTTAGAGTAGTGTTAATACCAGTTTTTATATTGTTTGCGTTAGTTGATTTTGGATTTGGCAATGTGTCATTTCTAGGAGGATATGAAATAAGAATTGAGTTATTAATCAGTGGTTTTATTTTTATATTGGCTTCCCTTAGCGATTTTGTTGATGGTTATTTAGCTAGAAAATGGAATTTAGTTACAAATATGGGGAAATTTTTGGATCCATTAGCGGATAAATTATTAGTTGCAAGTGCTTTAATTGTACTTGTGCAACTAGGACTAACAAATTCTGTAGTAGCAATCATTATTATTGCCAGAGAATTTGCCGTAACTGGTTTACGTTTACTACAAATTGAACAAGGATTCGTAAGTGCAGCTGGTCAATTAGGTAAAATTAAAACAGCAGTTACTATGGTAGCAATTACTTGGTTGTTATTAGGTGATCCATTGGCAACATTGATTGGTTTGTCATTAGGACAAATTTTATTATACATTGGCGTTATTTTTACTATCTTATCTGGTATTGAATACTTTTATAAAGGTAGAGATGTTTTTAAACAAAAATAA UPDATED NCBI_taxonomy_name with Staphylococcus aureus UPDATED NCBI_taxonomy_id with 1280 UPDATED NCBI_taxonomy_cvterm_id with 35508 UPDATED GI with WP_001025093 UPDATED sequence with MNIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIFILASLSDFVDGYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTNSVVAIIIIAREFAVTGLRLLQIEQGFVSAAGQLGKIKTAVTMVAITWLLLGDPLATLIGLSLGQILLYIGVIFTILSGIEYFYKGRDVFKQK UPDATED 2213 with A64V UPDATED 2229 with V59N UPDATED 2215 with K66R UPDATED 2214 with S177F " 229 UPDATE vanTmL glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-120 " 164 UPDATE vanN glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-170 " 90 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to rifampicin rifampin resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2862 with Q468K UPDATED 2055 with A473T UPDATED 2054 with H481N UPDATED 2057 with L466S UPDATED 2056 with Q465R UPDATED 2083 with A477T " 97 UPDATE vanXYC glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-130 " 2124 UPDATE Clostridium difficile EF-Tu mutants conferring resistance to elfamycin antibiotic resistant gene variant or mutant; elfamycin resistance gene; model_param "UPDATED 3422 with G261E UPDATED 3422 with G261E " 966 UPDATE vanSC glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1509 UPDATE vanXF glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 1626 UPDATE vgaE efflux pump conferring antibiotic resistance; streptogramin resistance gene; pleuromutilin resistance gene; ARO_category "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin " 2215 UPDATE Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolone gene involved in self resistance to antibiotic; antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; ARO_category; model_param "UPDATED category_aro_name with gene involved in self resistance to antibiotic UPDATED category_aro_cvterm_id with 36631 UPDATED category_aro_accession with 3000492 UPDATED category_aro_description with Genes that are involved in conferring self resistance to antibiotic UPDATED 3166 with E91K UPDATED 3167 with S87W UPDATED 3165 with S87L " 2158 UPDATE Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin antibiotic resistant gene variant or mutant; elfamycin resistance gene; model_param "UPDATED 2965 with R334C UPDATED 3019 with R234F UPDATED 2934 with T335A UPDATED 3030 with R231C UPDATED 3020 with R234S UPDATED 3044 with R231V " 1181 UPDATE cmeA efflux pump conferring antibiotic resistance; macrolide resistance gene; beta-lactam resistance gene; antibiotic inactivation enzyme; fluoroquinolone resistance gene; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 2109 UPDATE Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolone antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_sequences; model_param "UPDATED fmax with 7267 UPDATED strand with + UPDATED accession with NC_009525.1 UPDATED fmin with 5239 UPDATED sequence with GTGGCTGCCCAGAAAAAGAAGGCCCAAGACGAATACGGCGCTGCGTCTATCACCATTCTCGAAGGGCTGGAGGCCGTCCGCAAACGTCCCGGCATGTACATTGGCTCGACCGGTGAGCGCGGTTTACACCATCTCATTTGGGAGGTGGTCGACAACGCGGTCGACGAGGCGATGGCCGGTTATGCAACCACAGTGAACGTAGTGCTGCTTGAGGATGGCGGTGTCGAGGTCGCCGACGACGGCCGCGGCATTCCGGTCGCCACCCACGCCTCCGGCATACCGACCGTCGACGTGGTGATGACACAACTACATGCCGGCGGCAAGTTCGACTCGGACGCGTATGCGATATCTGGTGGTCTGCACGGCGTCGGCGTGTCGGTGGTTAACGCGCTATCCACCCGGCTCGAAGTCGAGATCAAGCGCGACGGGTACGAGTGGTCTCAGGTTTATGAGAAGTCGGAACCCCTGGGCCTCAAGCAAGGGGCGCCGACCAAGAAGACGGGGTCAACGGTGCGGTTCTGGGCCGACCCCGCTGTTTTCGAAACCACGGAATACGACTTCGAAACCGTCGCCCGCCGGCTGCAAGAGATGGCGTTCCTCAACAAGGGGCTGACCATCAACCTGACCGACGAGAGGGTGACCCAAGACGAGGTCGTCGACGAAGTGGTCAGCGACGTCGCCGAGGCGCCGAAGTCGGCAAGTGAACGCGCAGCCGAATCCACTGCACCGCACAAAGTTAAGAGCCGCACCTTTCACTATCCGGGTGGCCTGGTGGACTTCGTGAAACACATCAACCGCACCAAGAACGCGATTCATAGCAGCATCGTGGACTTTTCCGGCAAGGGCACCGGGCACGAGGTGGAGATCGCGATGCAATGGAACGCCGGGTATTCGGAGTCGGTGCACACCTTCGCCAACACCATCAACACCCACGAGGGCGGCACCCACGAAGAGGGCTTCCGCAGCGCGCTGACGTCGGTGGTGAACAAGTACGCCAAGGACCGCAAGCTACTGAAGGACAAGGACCCCAACCTCACCGGTGACGATATCCGGGAAGGCCTGGCCGCTGTGATCTCGGTGAAGGTCAGCGAACCGCAGTTCGAGGGCCAGACCAAGACCAAGTTGGGCAACACCGAGGTCAAATCGTTTGTGCAGAAGGTCTGTAACGAACAGCTGACCCACTGGTTTGAAGCCAACCCCACCGACGCGAAAGTCGTTGTGAACAAGGCTGTGTCCTCGGCGCAAGCCCGTATCGCGGCACGTAAGGCACGAGAGTTGGTGCGGCGTAAGAGCGCCACCGACATCGGTGGATTGCCCGGCAAGCTGGCCGATTGCCGTTCCACGGATCCGCGCAAGTCCGAACTGTATGTCGTAGAAGGTGACTCGGCCGGCGGTTCTGCAAAAAGCGGTCGCGATTCGATGTTCCAGGCGATACTTCCGCTGCGCGGCAAGATCATCAATGTGGAGAAAGCGCGCATCGACCGGGTGCTAAAGAACACCGAAGTTCAGGCGATCATCACGGCGCTGGGCACCGGGATCCACGACGAGTTCGATATCGGCAAGCTGCGCTACCACAAGATCGTGCTGATGGCCGACGCCGATGTTGACGGCCAACATATTTCCACGCTGTTGTTGACGTTGTTGTTCCGGTTCATGCGGCCGCTCATCGAGAACGGGCATGTGTTTTTGGCACAACCGCCGCTGTACAAACTCAAGTGGCAGCGCAGTGACCCGGAATTCGCATACTCCGACCGCGAGCGCGACGGTCTGCTGGAGGCGGGGCTGAAGGCCGGGAAGAAGATCAACAAGGAAGACGGCATTCAGCGGTACAAGGGTCTAGGTGAAATGGACGCTAAGGAGTTGTGGGAGACCACCATGGATCCCTCGGTTCGTGTGTTGCGTCAAGTGACGCTGGACGACGCCGCCGCCGCCGACGAGTTGTTCTCCATCCTGATGGGCGAGGACGTCGACGCGCGGCGCAGCTTTATCACCCGCAACGCCAAGGATGTTCGGTTCCTGGATGTCTAA UPDATED NCBI_taxonomy_name with Mycobacterium tuberculosis H37Ra UPDATED NCBI_taxonomy_id with 419947 UPDATED NCBI_taxonomy_cvterm_id with 40415 UPDATED GI with CAA55486.1 UPDATED sequence with MGKNEARRSALAPDHGTVVCDPLRRLNRMHATPEESIRIVAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV UPDATED 3462 with N538D UPDATED 3461 with D500H UPDATED 3460 with V340L UPDATED 3462 with N538D UPDATED 3461 with D500H UPDATED 3460 with V340L UPDATED param_type with single resistance variant UPDATED param_type_id with 36301 UPDATED param_description with A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s). " 2108 UPDATE Escherichia coli EF-Tu mutants conferring resistance to GE2270A antibiotic resistant gene variant or mutant; elfamycin resistance gene; model_param "UPDATED 3055 with G258A UPDATED 2952 with G276A " 1450 UPDATE Escherichia coli parC conferring resistance to fluoroquinolone gene involved in self resistance to antibiotic; antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; ARO_category; model_param "UPDATED category_aro_name with gene involved in self resistance to antibiotic UPDATED category_aro_cvterm_id with 36631 UPDATED category_aro_accession with 3000492 UPDATED category_aro_description with Genes that are involved in conferring self resistance to antibiotic DELETED 2191 UPDATED 3543 with E84G UPDATED 2176 with S80I UPDATED 3543 with E84G " 2054 UPDATE msrC efflux pump conferring antibiotic resistance; streptogramin resistance gene; macrolide resistance gene; model_sequences; model_param "DELETED 364 UPDATED param_value with 1e-130 " 1976 UPDATE mefA efflux pump conferring antibiotic resistance; macrolide resistance gene; model_param "UPDATED param_value with 1e-100 " 111 UPDATE Escherichia coli gyrB conferring resistance to aminocoumarin aminocoumarin resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2158 with R136H UPDATED 2160 with R136G UPDATED 2156 with R136L UPDATED 2157 with R136C UPDATED 2161 with R136I UPDATED 2159 with R136S UPDATED 2162 with R136E " 2100 UPDATE Mycobacterium chelonae 16S rRNA mutation conferring resistance to amikacin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2981 with A1355G " 1510 UPDATE vanTrL glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1108 UPDATE Enterococcus faecium liaS mutant conferring daptomycin resistance peptide antibiotic resistance gene; antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_param "UPDATED 39 with A180T UPDATED 2203 with E192G UPDATED 44 with T120A UPDATED 2252 with H264Q " 2104 UPDATE Ureaplasma urealyticum parC conferring resistance to fluoroquinolone gene involved in self resistance to antibiotic; antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; ARO_category; model_param "UPDATED category_aro_name with gene involved in self resistance to antibiotic UPDATED category_aro_cvterm_id with 36631 UPDATED category_aro_accession with 3000492 UPDATED category_aro_description with Genes that are involved in conferring self resistance to antibiotic UPDATED 2946 with S83L UPDATED 3051 with S84P UPDATED 2940 with S83W " 1166 UPDATE Staphylococcus aureus gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 2118 with S85P UPDATED 2119 with E88K UPDATED 2120 with E88A UPDATED 2117 with S84L " 606 UPDATE IMI-2 antibiotic inactivation enzyme; beta-lactam resistance gene; model_param "UPDATED param_value with 1e-160 " 744 UPDATE vanSL glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 558 UPDATE qacB efflux pump conferring antibiotic resistance; fluoroquinolone resistance gene; model_param "UPDATED param_value with 1e-100 " 1033 UPDATE vanSN glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1607 UPDATE PBP1a antibiotic inactivation enzyme; beta-lactam resistance gene; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 159 UPDATE vgaALC efflux pump conferring antibiotic resistance; streptogramin resistance gene; pleuromutilin resistance gene; ARO_category "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin " 158 UPDATE myrA antibiotic target modifying enzyme; gene involved in self resistance to antibiotic; macrolide resistance gene; model_param "UPDATED param_value with 1e-90 " 1203 UPDATE Mycobacterium tuberculosis ndh mutant conferring resistance to isoniazid antibiotic resistant gene variant or mutant; isoniazid resistance gene; ARO_description; model_param "UPDATED ARO_description with Mutations in the Mycobacterium tuberculosis ndh gene that results in increased resistance to isoniazid. UPDATED 3646 with L50V UPDATED 3644 with G313R UPDATED 3643 with T110A UPDATED 3642 with R268H UPDATED 3641 with A300P UPDATED 2310 with V18A UPDATED 2402 with R13C UPDATED 3646 with L50V UPDATED 3644 with G313R UPDATED 3643 with T110A UPDATED 3642 with R268H UPDATED 3641 with A300P " 36 UPDATE Mycobaterium leprae gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 2127 with A91T " _timestamp N/A N/A N/A N/A NEW: 2016-06-06T21:07:56+00:00 , OLD: 2016-05-03T18:38:01+00:00 1899 UPDATE vanYF glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-130 " 1894 UPDATE Salmonella serovars ramR mutants chloramphenicol resistance gene; gene modulating antibiotic efflux; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; model_param "UPDATED 2136 with R46P UPDATED 2137 with M84I UPDATED 2864 with E160D UPDATED 2138 with Y59H UPDATED 2139 with T18P UPDATED 2155 with G25A " 722 UPDATE vanRA glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 2136 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to kanamycin A antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3068 with T1406A UPDATED 2904 with A1408G " 2137 UPDATE Escherichia coli EF-Tu mutants conferring resistance to kirromycin antibiotic resistant gene variant or mutant; elfamycin resistance gene; model_sequences; model_param "UPDATED fmax with 2945 UPDATED strand with + UPDATED accession with AH002539.2 UPDATED fmin with 1760 UPDATED sequence with GTGTCTAAAGAAAAATTTGAACGTACAAAACCGCACGTTAACGTTGGTACTATCGGCCACGTTGACCACGGTAAAACTACTCTGACCGCTGCAATCACCACCGTACTGGCTAAAACCTACGGCGGTGCTGCTCGTGCATTCGACCAGATCGATAACGCGCCGGAAGAAAAAGCTCGTGGTATCACCATCAACACTTCTCACGTTGAATACGACACCCCGACCCGTCACTACGCACACGTAGACTGCCCGGGGCACGCCGACTATGTTAAAAACATGATCACCGGTGCTGCTCAGATGGACGGCGCGATCCTGGTAGTTGCTGCGACTGACGGCCCGATGCCGCAGACTCGTGAGCACATCCTGCTGGGTCGTCAGGTAGGCGTTCCGTACATCATCGTGTTCCTGAACAAATGCGACATGGTTGATGACGAAGAGCTGCTGGAACTGGTTGAAATGGAAGTTCGTGAACTTCTGTCTCAGTACGACTTCCCGGGCGACGACACTCCGATCGTTCGTGGTTCTGCTCTGAAAGCGCTGGAAGGCGACGCAGAGTGGGAAGCGAAAATCCTGGAACTGGCTGGCTTCCTGGATTCTTATATTCCGGAACCAGAGCGTGCGATTGACAAGCCGTTCCTGCTGCCGATCGAAGACGTATTCTCCATCTCCGGTCGTGGTACCGTTGTTACCGGTCGTGTAGAACGCGGTATCATCAAAGTTGGTGAAGAAGTTGAAATCGTTGGTATCAAAGAGACTCAGAAGTCTACCTGTACTGGCGTTGAAATGTTCCGCAAACTGCTGGACGAAGGCCGTGCTGGTGAGAACGTAGGTGTTCTGCTGCGTGGTATCAAACGTGAAGAAATCGAACGTGGTCAGGTACTGGCTAAGCCGGGCACCATCAAGCCGCACACCAAGTTCGAATCTGAAGTGTACATTCTGTCCAAAGATGAAGGCGGCCGTCATACTCCGTTCTTCAAAGGCTACCGTCCGCAGTTCTACTTCCGTACTACTGACGTGACTGGTACCATCGAACTGCCGGAAGGCGTAGAGATGGTAATGCCGGGCGACAACATCAAAATGGTTGTTACCCTGATCCACCCGATCGCGATGGACGACGGTCTGCGTTTCGCAATCCGTGAAGGCGGCCGTACCGTTGGCGCGGGCGTTGTTGCTAAAGTTCTGGGCTAA UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED GI with AAA50993.1 UPDATED sequence with MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG DELETED 2903 UPDATED 3305 with A376V UPDATED 3306 with Y161D UPDATED 3308 with L121Q UPDATED 3310 with A376S UPDATED 3311 with Q125E UPDATED 3307 with Y161N UPDATED 3313 with Y161C UPDATED 3312 with E379K UPDATED 3302 with G317D UPDATED 3303 with Q125R UPDATED 2947 with Q125K UPDATED 3312 with E379K UPDATED 3311 with Q125E UPDATED 3308 with L121Q UPDATED 3310 with A376S UPDATED 3306 with Y161D UPDATED 3307 with Y161N UPDATED 3313 with Y161C UPDATED 3305 with A376V UPDATED 3302 with G317D UPDATED 3303 with Q125R " 1817 UPDATE vgaB efflux pump conferring antibiotic resistance; streptogramin resistance gene; pleuromutilin resistance gene; ARO_category "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin " 2132 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3026 with C1402T UPDATED 2923 with C1402A UPDATED 3014 with A1401G UPDATED 3040 with G1484T " 2133 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to viomycin peptide antibiotic resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 2909 with A1401G " 1240 UPDATE Bacillus intrinsic mph macrolide resistance gene; antibiotic inactivation enzyme; ARO_description; ARO_name "UPDATED ARO_description with Bacillus Cluster A mph are chromosomally-encoded macrolide phosphotransferases that inactivate 14- and 15-membered macrolides such as erythromycin, clarithromycin, azithromycin. UPDATED ARO_name with Bacillus Cluster A intrinsic mph " 1617 UPDATE vanE glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 1966 UPDATE lmrA lincosamide resistance gene; antibiotic resistant gene variant or mutant; gene modulating antibiotic efflux; model_param "UPDATED 2887 with Q52P " 2223 UPDATE mexZ chloramphenicol resistance gene; gene modulating antibiotic efflux; macrolide resistance gene; aminoglycoside resistance gene; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; tetracycline resistance gene; beta-lactam resistance gene; model_param "UPDATED 3173 with V44A UPDATED 3175 with Q10Z UPDATED 3174 with G46S UPDATED 3168 with G195E " 2138 UPDATE NmcA beta-lactamase antibiotic inactivation enzyme; beta-lactam resistance gene; model_param "UPDATED param_value with 1e-160 " 2139 UPDATE vanSD glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1696 UPDATE Salmonella serovars gyrB conferring resistance to fluoroquinolone antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 2174 with E466D " 1298 UPDATE lsaA efflux pump conferring antibiotic resistance; streptogramin resistance gene; lincosamide resistance gene; pleuromutilin resistance gene; ARO_category; model_param "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin UPDATED param_value with 1e-140 " 1759 UPDATE vanF glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-180 " 1561 UPDATE vanTG glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-150 " 1635 UPDATE vanRG glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1754 UPDATE vanO glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-170 " 1566 UPDATE vanXD glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-130 " 1699 UPDATE vanXO glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1176 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid antibiotic resistant gene variant or mutant; isoniazid resistance gene; model_param "UPDATED 3240 with L101P UPDATED 3236 with P131R UPDATED 3237 with N194Y UPDATED 3243 with V68G UPDATED 3242 with P131Q UPDATED 3238 with W91R UPDATED 3239 with R463L UPDATED 3247 with S315I UPDATED 3246 with M126I UPDATED 3245 with S315N UPDATED 3244 with A234G UPDATED 2284 with S315T UPDATED 3241 with R128Q " 1175 UPDATE Enterococcus faecium cls conferring resistance to daptomycin antibiotic resistant gene variant or mutant; lipopeptide antibiotic resistance gene; model_sequences; model_param "UPDATED fmax with 1010292 UPDATED strand with - UPDATED accession with JPPA01000001.1 UPDATED fmin with 1008840 UPDATED sequence with TTATAGGATTGGAGAAAATAATCGAGAAATTTGTTGCTTGAATAATAGCCAGTTAGACATTTCCTTGACTGTTTCAGTTGTCATGGATGAACAATGTGTCTCATCTTCTTTGAACTGAGTAGCAAGTTCTTCTAAAAACTCAGGATCGTAAATGACAGCACTTGTTTCAAAATTCAATCGGTAGCTACGAATATCTTGATTTGCTGAACCTACCATGCAGATTTCATCATCCATTATCAATGTTTTTGCATGGAGGAAGCCGTTCTCATAGACAAGGATTTGTACATTTTCCTTGATCAGCTGCCGAGCATAATATTGTGTTGCTCGATAAATAAAAGGATGATCCGGTTTGTTGGGAATCATGATTTTCACATCTACACCAGAGGCAGTTGCGATTTTTAAAGCAGCAATGACACTTTCATCAGGAACAAGGTAAGGTGTCTGTATCCAAACACGTTTTTTAGCAGAAGTAATCAATTTGATAAATGAAAGCTTGATTTGTTCCCTTTCGTTATTCGGTCCGCTTGAAACAAGCTGGATGGATGTATCAGCAAGCTTAGATTCATCTCGATCTGCTTTTTTAAAGAAATAATTCAAATGATAGCCGACCTTTTTTTCTTCAGGTACCGAGACGTTCCAGTCTGTTAAGAAGCGAAGCTGGAGCAAAGAAGAAGCGGCACCGAAAATCCGTATATGCGTATCGCGCCAATAGCCGAATTTTTTTGTTGTATTTACATATTGATTGGCAATATTGAAACCACCGGTATAACTAATCTTTCCATCGATCACAACGATTTTTCGGTGATCATGGTAATTCAATCGGAAACGAAGTAATGCCCTTTGTGAGGTAACAAATGTATGGACATGTCCACCATTTTTGATTAGACGATTGAAATCTTTTGCTTTTGTGCCATGAGAGCCAAATGCATCATATAATATTCGAACTTCCACGCCTTCTGCGGCTTTTTCTTCTAAAACATGTAAGACTTGCTGGCCGATATTATCTGTCACAAATGCGTAATATTCGATATGGATCGAATGTTTGGCTTTTTTTAGATCTTGAAGCAGTGAATCCAATTTCTCTTGTCCGTCTGTGAGAAGAGTGACAGAATTCATTCTTGTCAGCGGCATACGATTTAATGAAGAGAAGAAGTCAACAAATTGCTGTTTGTCTTTATCGCCCATGTCAGGATCGTAATGTTCAATGGTATCTCCTCTAAAAGACTGAAAGTTTTCTAATTCTTTCAAGTCACTTTGTCGGAGATAGAATTTTTTCTTATCCGTTAATCCACGTCCGAAAAATAAATATAATACAAAGCCCACCCCAGGAAGGGCAAATAATACTAAGAGCCATGCCCAAATGGCTGCTACATCTCGGGGTTTGATCAAAATAGCCACCAAAGCAATAAGTGCATTTAATAGATAAAGGGCGGTTATAATACTAGATACCAC UPDATED NCBI_taxonomy_name with Enterococcus faecium UPDATED NCBI_taxonomy_id with 1352 UPDATED NCBI_taxonomy_cvterm_id with 36779 UPDATED GI with AVIW01000092.1 UPDATED sequence with MVSSIITALYLLNALIALVAILIKPRDVAAIWAWLLVLFALPGVGFVLYLFFGRGLTDKKKFYLRQSDLKELENFQSFRGDTIEHYDPDMGDKDKQQFVDFFSSLNRMPLTRMNSVTLLTDGQEKLDSLLQDLKKAKHSIHIEYYAFVTDNIGQQVLHVLEEKAAEGVEVRILYDAFGSHGTKAKDFNRLIKNGGHVHTFVTSQRALLRFRLNYHDHRKIVVIDGKISYTGGFNIANQYVNTTKKFGYWRDTHIRIFGAASSLLQLRFLTDWNVSVPEEKKVGYHLNYFFKKADRDESKLADTSIQLVSSGPNNEREQIKLSFIKLITSAKKRVWIQTPYLVPDESVIAALKIATASGVDVKIMIPNKPDHPFIYRATQYYARQLIKENVQILVYENGFLHAKTLIMDDEICMVGSANQDIRSYRLNFETSAVIYDPEFLEELATQFKEDETHCSSMTTETVKEMSNWLLFKQQISRLFSPIL UPDATED 3574 with N13I UPDATED 3584 with A20D UPDATED 3585 with R267H UPDATED 3586 with D27N UPDATED 3578 with N13T UPDATED 3578 with N13T UPDATED 3584 with A20D UPDATED 3585 with R267H UPDATED 3586 with D27N UPDATED 3574 with N13I UPDATED 2073 with R218Q UPDATED 2072 with H215R UPDATED 2075 with K59T UPDATED 2074 with G178T " 89 UPDATE vanYA glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-130 " 1360 UPDATE Bartonella bacilliformis gyrB conferring resistance to aminocoumarin aminocoumarin resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 3430 with T214A UPDATED 3431 with T214I UPDATED 3429 with R184Q UPDATED 3428 with G124S UPDATED 3430 with T214A UPDATED 3431 with T214I UPDATED 3429 with R184Q UPDATED 3428 with G124S " 141 UPDATE vanRB glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 2106 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsA gene conferring resistance to kanamycin A antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2929 with A1391G UPDATED 2970 with T1389A " 1340 UPDATE mtrC efflux pump conferring antibiotic resistance; model_param "UPDATED param_value with 1e-100 " 2148 UPDATE Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolone antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 3048 with P462S " 1595 UPDATE mecB antibiotic resistance gene cluster, cassette, or operon; antibiotic inactivation enzyme; beta-lactam resistance gene; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 1647 UPDATE mexI efflux pump conferring antibiotic resistance; fluoroquinolone resistance gene; model_param "UPDATED param_value with 1e-170 " 489 UPDATE Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin antibiotic target modifying enzyme; antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3683 with G164C UPDATED 3682 with L49F UPDATED 3681 with L79F UPDATED 3678 with N52T UPDATED 3679 with G117E UPDATED 3672 with W45S UPDATED 3673 with P84L UPDATED 3670 with A183T UPDATED 3676 with G30R UPDATED 3675 with H48Y UPDATED 3678 with N52T UPDATED 3679 with G117E UPDATED 3672 with W45S UPDATED 3673 with P84L UPDATED 3670 with A183T UPDATED 3676 with G30R UPDATED 3675 with H48Y UPDATED 3235 with P75S UPDATED 2666 with D67H UPDATED 2667 with S70R UPDATED 2664 with R47Q UPDATED 2665 with I55S UPDATED 2662 with L16R UPDATED 2663 with W45C UPDATED 2668 with G71V UPDATED 3683 with G164C UPDATED 3682 with L49F UPDATED 3681 with L79F UPDATED 2671 with A134E UPDATED 2670 with Q127P UPDATED 2673 with W148R UPDATED 2672 with A138E UPDATED 2675 with V188G UPDATED 2674 with A183E UPDATED 2676 with A200E " 487 UPDATE macB efflux pump conferring antibiotic resistance; macrolide resistance gene; model_param "UPDATED param_value with 1e-120 " 1354 UPDATE Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol ethambutol resistance gene; antibiotic resistant gene variant or mutant; model_param "UPDATED 3583 with G5S UPDATED 3583 with G5S UPDATED 2396 with A201T UPDATED 2397 with G321S UPDATED 2395 with D4N UPDATED 2400 with D833A UPDATED 2401 with P913S UPDATED 2398 with G350D UPDATED 2399 with A462V " 1671 UPDATE Salmonella serovars soxS mutants chloramphenicol resistance gene; gene modulating antibiotic efflux; gene modulating permeability to antibiotic; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; model_param "UPDATED 2234 with E52K " 1055 UPDATE Escherichia coli parE conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; model_param "UPDATED 2226 with D476N " 2239 UPDATE ampC antibiotic inactivation enzyme; beta-lactam resistance gene; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. UPDATED category_aro_name with beta-lactam resistance gene UPDATED category_aro_cvterm_id with 36268 UPDATED category_aro_accession with 3000129 UPDATED category_aro_description with Genes conferring resistance to beta-lactams. " 1608 UPDATE mexT efflux pump conferring antibiotic resistance; chloramphenicol resistance gene; trimethoprim resistance gene; gene modulating antibiotic efflux; fluoroquinolone resistance gene; model_param "UPDATED param_value with 1e-100 " 2088 UPDATE Mycobacterium smegmatis 16S rRNA mutation in the rrsB gene conferring resistance to streptomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 3056 with G504C UPDATED 2978 with C506T UPDATED 2927 with C502T UPDATED 2948 with A503C " 2122 UPDATE Mycobacterium chelonae 16S rRNA mutation conferring resistance to neomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2953 with A1355G " 1046 UPDATE vgaD efflux pump conferring antibiotic resistance; streptogramin resistance gene; pleuromutilin resistance gene; ARO_category "UPDATED category_aro_name with pleuromutilin resistance gene UPDATED category_aro_cvterm_id with 40410 UPDATED category_aro_accession with 3003753 UPDATED category_aro_description with Genes conferring resistance to pleuromutilin " 948 UPDATE mecI antibiotic resistance gene cluster, cassette, or operon; antibiotic inactivation enzyme; beta-lactam resistance gene; gene modulating beta-lactam resistance; antibiotic target replacement protein; ARO_category "UPDATED category_aro_name with antibiotic inactivation enzyme UPDATED category_aro_cvterm_id with 36696 UPDATED category_aro_accession with 3000557 UPDATED category_aro_description with Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. " 2126 UPDATE Mycobacterium abscessus 16S rRNA mutation conferring resistance to tobramycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2918 with C1376T UPDATED 2920 with G1458T UPDATED 3049 with A1375G UPDATED 2926 with T1373A " 2129 UPDATE Escherichia coli 16S rRNA mutation in the rrsB gene conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2910 with C1192A UPDATED 2919 with G1064A UPDATED 3023 with G1064T UPDATED 3070 with C1192G UPDATED 2959 with G1064C UPDATED 3064 with C1066T UPDATED 3046 with C1192T " 2083 UPDATE Mycoplasma hominis parC conferring resistance to fluoroquinolone gene involved in self resistance to antibiotic; antibiotic resistant gene variant or mutant; fluoroquinolone resistance gene; ARO_category; model_param "UPDATED category_aro_name with gene involved in self resistance to antibiotic UPDATED category_aro_cvterm_id with 36631 UPDATED category_aro_accession with 3000492 UPDATED category_aro_description with Genes that are involved in conferring self resistance to antibiotic UPDATED 3545 with K134R UPDATED 3545 with K134R " 2080 UPDATE Escherichia coli 16S rRNA mutation in the rrsH gene conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2933 with C1192T " 2131 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2911 with A1401G UPDATED 2989 with C513T UPDATED 3039 with C526T UPDATED 2938 with C517T UPDATED 3067 with A514T UPDATED 2949 with G427C UPDATED 3057 with C492T UPDATED 3054 with A906G UPDATED 3052 with A514C " 2086 UPDATE Escherichia coli 16S rRNA mutation in the rrnB gene conferring resistance to tetracycline antibiotic resistant gene variant or mutant; tetracycline resistance gene; model_param "UPDATED 3071 with G1053A UPDATED 2956 with C1054T UPDATED 2900 with A964G UPDATED 2988 with A1055G " 943 UPDATE vanU glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-50 " 2084 UPDATE Mycobacterium abscessus 16S rRNA mutation conferring resistance to amikacin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2972 with G1458T UPDATED 3036 with A1375G UPDATED 2993 with T1373A UPDATED 3011 with C1376T " 2085 UPDATE Escherichia coli 16S rRNA mutation in the rrnB gene conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; aminoglycoside resistance gene; model_param "UPDATED 2925 with G1068A " 1198 UPDATE mefB efflux pump conferring antibiotic resistance; macrolide resistance gene; model_param "UPDATED param_value with 1e-100 " 1474 UPDATE mexR chloramphenicol resistance gene; gene modulating antibiotic efflux; beta-lactam resistance gene; aminocoumarin resistance gene; macrolide resistance gene; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; polymyxin resistance gene; trimethoprim resistance gene; model_param "UPDATED 2889 with I46N UPDATED 2763 with R83C UPDATED 2762 with L75R UPDATED 2761 with L75P UPDATED 2760 with I72N UPDATED 2891 with T69I UPDATED 2890 with L57R UPDATED 2825 with R91C UPDATED 2826 with R91H UPDATED 2888 with L45P " 350 UPDATE ykkD efflux pump conferring antibiotic resistance; chloramphenicol resistance gene; tetracycline resistance gene; model_param "UPDATED param_value with 1e-60 " 1689 UPDATE vanRO glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 1571 UPDATE vanSE glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-140 " 559 UPDATE vanXYE glycopeptide resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_param "UPDATED param_value with 1e-130 " 2224 UPDATE oprD gene modulating permeability to antibiotic; model_param "UPDATED 3176 with Q142X " 1368 UPDATE abeM efflux pump conferring antibiotic resistance; model_param "UPDATED param_value with 1e-100 " 1574 UPDATE Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid antibiotic resistant gene variant or mutant; isoniazid resistance gene; model_param "UPDATED 2288 with I95P UPDATED 2289 with I194T UPDATED 2709 with I16T UPDATED 2224 with S94A UPDATED 2222 with I47T UPDATED 2223 with V78A UPDATED 2220 with I21V UPDATED 2221 with I21T " 2095 DELETE elongation factor Tu N/A N/A 2134 DELETE CMY-36 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2135 DELETE ACT-33 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2130 DELETE opcM efflux pump conferring antibiotic resistance; aminoglycoside resistance gene; fluoroquinolone resistance gene; N/A N/A 859 DELETE AER-14 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2118 DELETE OXA-193 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2119 DELETE LRA-10 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2156 DELETE NDM-14 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2150 DELETE efflux pump conferring antibiotic resistance N/A N/A 2151 DELETE resistance-nodulation-cell division (RND) antibiotic efflux pump efflux pump conferring antibiotic resistance; N/A N/A 2153 DELETE acridine dye N/A N/A 2110 DELETE CARB-20 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2112 DELETE patB efflux pump conferring antibiotic resistance; fluoroquinolone resistance gene; N/A N/A 2247 DELETE hydroxypropylphosphonic acid epoxidase N/A N/A 2114 DELETE APH(3')-IIa antibiotic inactivation enzyme; aminoglycoside resistance gene; N/A N/A 2115 DELETE TEM-4 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2075 DELETE Salmonella serovars soxR mutants chloramphenicol resistance gene; gene modulating antibiotic efflux; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; antibiotic resistant gene variant or mutant; tetracycline resistance gene; rifampin resistance gene; beta-lactam resistance gene; N/A N/A 2117 DELETE AAC(6')-Ib7 antibiotic inactivation enzyme; aminoglycoside resistance gene; N/A N/A 651 DELETE mprF antibiotic target modifying enzyme; peptide antibiotic resistance gene; N/A N/A 2187 DELETE Staphylococcus aureus parE conferring resistance to aminocoumarin N/A N/A 2079 DELETE sgm antibiotic target modifying enzyme; aminoglycoside resistance gene; N/A N/A 2189 DELETE Ureaplasma urealyticum parC conferring resistance to fluoroquinolone N/A N/A 2188 DELETE Mycoplasma hominis parC conferring resistance to fluoroquinolone N/A N/A 2071 DELETE AAC(6')-Ib8 antibiotic inactivation enzyme; aminoglycoside resistance gene; N/A N/A 2121 DELETE LRA-7 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2120 DELETE MacAB-TolC efflux pump conferring antibiotic resistance; macrolide resistance gene; N/A N/A 2123 DELETE vgaC efflux pump conferring antibiotic resistance; streptogramin resistance gene; N/A N/A 2089 DELETE TEM-31 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2125 DELETE major facilitator superfamily (MFS) antibiotic efflux pump efflux pump conferring antibiotic resistance; N/A N/A 2082 DELETE CMY-106 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2081 DELETE patA efflux pump conferring antibiotic resistance; fluoroquinolone resistance gene; N/A N/A 2159 DELETE 23S rRNA with mutation conferring antibiotic resistance antibiotic resistant gene variant or mutant; N/A N/A 2168 DELETE fluoroquinolone sensitive parC N/A N/A 2103 DELETE SHV-3 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2101 DELETE ATP-binding cassette (ABC) antibiotic efflux pump efflux pump conferring antibiotic resistance; N/A N/A 2166 DELETE fluoroquinolone sensitive gyrA N/A N/A 2064 DELETE TEM-196 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2067 DELETE CMY-131 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2269 ADD Escherichia coli nfsB mutations conferring resistance to nitrofurantoin nitrofuratoin resistance gene; antibiotic resistant gene variant or mutant; N/A N/A 2248 ADD fusD antibiotic inactivation enzyme; fusidic acid resistance gene; N/A N/A 2249 ADD LpxA polymyxin resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistant gene variant or mutant; N/A N/A 2262 ADD mefC efflux pump conferring antibiotic resistance; macrolide resistance gene; N/A N/A 2260 ADD vatF antibiotic inactivation enzyme; streptogramin resistance gene; N/A N/A 2261 ADD lnuE lincosamide resistance gene; antibiotic inactivation enzyme; N/A N/A 2267 ADD Escherichia coli nfsA mutations conferring resistance to nitrofurantoin nitrofuratoin resistance gene; antibiotic resistant gene variant or mutant; N/A N/A 2264 ADD oleC efflux pump conferring antibiotic resistance; N/A N/A 2265 ADD salA efflux pump conferring antibiotic resistance; lincosamide resistance gene; pleuromutilin resistance gene; streptogramin resistance gene; N/A N/A 2288 ADD Mycobacterium bovis mutant ndh conferring resistance to isoniazid antibiotic resistant gene variant or mutant; isoniazid resistance gene; N/A N/A 2281 ADD Brucella suis mprF antibiotic target modifying enzyme; peptide antibiotic resistance gene; N/A N/A 2282 ADD Clostridium perfringens mprF antibiotic target modifying enzyme; peptide antibiotic resistance gene; N/A N/A 2283 ADD Streptococcus agalactiae mprF antibiotic target modifying enzyme; peptide antibiotic resistance gene; N/A N/A 2284 ADD Escherichia coli mutant murA conferring resistance to fosfomycin fosfomycin resistance gene; antibiotic resistant gene variant or mutant; N/A N/A 2286 ADD Borrelia burgdorferi mutant murA conferring resistance to fosfomycin fosfomycin resistance gene; antibiotic resistant gene variant or mutant; N/A N/A 2287 ADD Mycobacterium smegmatis mutant ndh conferring resistance to isoniazid antibiotic resistant gene variant or mutant; isoniazid resistance gene; N/A N/A 2275 ADD desR gene involved in self resistance to antibiotic; N/A N/A 2274 ADD RlmA(II) antibiotic target modifying enzyme; gene involved in self resistance to antibiotic; macrolide resistance gene; N/A N/A 2277 ADD Bacillus Cluster B intrinsic mph macrolide resistance gene; antibiotic inactivation enzyme; N/A N/A 2273 ADD oleR gene involved in self resistance to antibiotic; N/A N/A 2279 ADD Listeria monocytogenes mprF antibiotic target modifying enzyme; peptide antibiotic resistance gene; N/A N/A 2278 ADD Bifidobacteria intrinsic ileS conferring resistance to mupirocin mupirocin resistance gene; N/A N/A 2259 ADD mphG macrolide resistance gene; antibiotic inactivation enzyme; N/A N/A 2257 ADD Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A antibiotic resistant gene variant or mutant; elfamycin resistance gene; N/A N/A 2252 ADD LpxD polymyxin resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistant gene variant or mutant; N/A N/A 2251 ADD LpxC polymyxin resistance gene; gene conferring antibiotic resistance via molecular bypass; antibiotic resistant gene variant or mutant; N/A N/A