{"$update": {"489": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3689": "V188M", "3688": "P84C"}}, "clinical": {"$insert": {"3689": "V188M", "3688": "P84C"}}}}}}}}, "455": {"$update": {"ARO_description": "VanC is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is specific to Enterococcus gallinarum and E. casseliflavus, providing intrinsic resistance."}}, "333": {"$update": {"ARO_description": "Present in Lahey's list of beta-lactamases, not yet released"}}, "660": {"$update": {"model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "model_param": {"$delete": ["snp"]}, "model_type_id": "40292"}}, "1924": {"$update": {"ARO_description": "VanM is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance."}}, "794": {"$update": {"model_param": {"$update": {"snp": {"$delete": ["clinical"], "$insert": {"experimental": {"2071": "Q961K", "2070": "F632S"}}}}}}}, "1981": {"$update": {"ARO_description": "VanA is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with both vancomycin and teicoplanin resistance."}}, "1617": {"$update": {"ARO_description": "VanE is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis"}}, "1446": {"$update": {"ARO_description": "PDC-6 is a beta-lactamase found in Pseudomonas aeruginosa."}}, "1759": {"$update": {"ARO_description": "VanF is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance in Paenibacillus popilliae"}}, "366": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3856": "P3A", "3857": "R537H"}}}, "$insert": {"clinical": {"3856": "P3A", "3857": "R537H"}}}}}}}, "1754": {"$update": {"ARO_description": "VanO is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance."}}, "349": {"$update": {"ARO_description": "VanL is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis"}}, "1176": {"$update": {"ARO_description": "katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent.", "model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["3237"], "$insert": {"3759": "T667P", "3714": "D735N", "3770": "A431V", "3711": "S315R", "3710": "S315G", "3713": "G629S", "3712": "L587M", "3805": "A243S", "3804": "Q224E", "3807": "P2S", "3806": "A550D", "3755": "V47E", "3754": "G32D", "3803": "G19D", "3802": "S17N", "3724": "P232S", "3793": "D36E", "3725": "N133T", "3737": "D542H", "3777": "S17T", "3735": "R632C", "3734": "M176T", "3733": "D419H", "3732": "G299S", "3731": "G123E", "3808": "S140N", "3698": "W107R", "3699": "H108E", "3727": "H97R", "3798": "Q295H", "3795": "A139V", "3794": "A110V", "3797": "H276M", "3796": "G300W", "3696": "D63E", "3697": "R104L", "3751": "Q439P", "3762": "I335T", "3704": "W300G", "3769": "G269R", "3730": "D387H", "3750": "T394M", "3753": "A541D", "3813": "S457I", "3812": "G316D", "3761": "A717P", "3810": "G279D", "3811": "G285D", "3764": "Q127P", "3766": "Q352E", "3767": "Y98C", "3746": "G269D", "3747": "T306P", "3744": "D142G", "3745": "A162V", "3742": "P131T", "3743": "A139P", "3740": "Y64S", "3741": "Y95C", "3748": "R385W", "3708": "Y337C", "3709": "A350S", "3728": "R489S", "3757": "A256T", "3702": "N138S", "3703": "Y229F", "3726": "S383P", "3701": "N138D", "3706": "T275P", "3707": "W328G", "3693": "D194Y", "3723": "Q127E", "3700": "H108Q", "3752": "F483L", "3786": "A93T", "3768": "A379T", "3749": "D387G", "3756": "D194G", "3705": "T262R", "3760": "M624V", "3814": "G593D", "3729": "M420T"}}, "clinical": {"$delete": ["3237"], "$insert": {"3759": "T667P", "3714": "D735N", "3770": "A431V", "3711": "S315R", "3710": "S315G", "3713": "G629S", "3712": "L587M", "3805": "A243S", "3804": "Q224E", "3807": "P2S", "3806": "A550D", "3755": "V47E", "3754": "G32D", "3803": "G19D", "3802": "S17N", "3724": "P232S", "3793": "D36E", "3725": "N133T", "3737": "D542H", "3777": "S17T", "3735": "R632C", "3734": "M176T", "3733": "D419H", "3732": "G299S", "3731": "G123E", "3808": "S140N", "3698": "W107R", "3699": "H108E", "3727": "H97R", "3798": "Q295H", "3795": "A139V", "3794": "A110V", "3797": "H276M", "3796": "G300W", "3696": "D63E", "3697": "R104L", "3751": "Q439P", "3762": "I335T", "3704": "W300G", "3769": "G269R", "3730": "D387H", "3750": "T394M", "3753": "A541D", "3813": "S457I", "3812": "G316D", "3761": "A717P", "3810": "G279D", "3811": "G285D", "3764": "Q127P", "3766": "Q352E", "3767": "Y98C", "3746": "G269D", "3747": "T306P", "3744": "D142G", "3745": "A162V", "3742": "P131T", "3743": "A139P", "3740": "Y64S", "3741": "Y95C", "3748": "R385W", "3708": "Y337C", "3709": "A350S", "3728": "R489S", "3757": "A256T", "3702": "N138S", "3703": "Y229F", "3726": "S383P", "3701": "N138D", "3706": "T275P", "3707": "W328G", "3693": "D194Y", "3723": "Q127E", "3700": "H108Q", "3752": "F483L", "3786": "A93T", "3768": "A379T", "3749": "D387G", "3756": "D194G", "3705": "T262R", "3760": "M624V", "3814": "G593D", "3729": "M420T"}}}}}}}}, "1175": {"$update": {"model_sequences": {"$update": {"sequence": {"3560": {"dna_sequence": {"fmax": "1010292", "fmin": "1008840", "accession": "CP013009", "strand": "-", "sequence": "TTATAGGATTGGAGAAAATAATCGAGAAATTTGTTGCTTGAATAATAGCCAGTTAGACATTTCCTTGACTGTTTCAGTTGTCATGGATGAACAATGTGTCTCATCTTCTTTGAACTGAGTAGCAAGTTCTTCTAAAAACTCAGGATCGTAAATGACAGCACTTGTTTCAAAATTCAATCGGTAGCTACGAATATCTTGATTTGCTGAACCTACCATGCAGATTTCATCATCCATTATCAATGTTTTTGCATGGAGGAAGCCGTTCTCATAGACAAGGATTTGTACATTTTCCTTGATCAGCTGCCGAGCATAATATTGTGTTGCTCGATAAATAAAAGGATGATCCGGTTTGTTGGGAATCATGATTTTCACATCTACACCAGAGGCAGTTGCGATTTTTAAAGCAGCAATGACACTTTCATCAGGAACAAGGTAAGGTGTCTGTATCCAAACACGTTTTTTAGCAGAAGTAATCAATTTGATAAATGAAAGCTTGATTTGTTCCCTTTCGTTATTCGGTCCGCTTGAAACAAGCTGGATGGATGTATCAGCAAGCTTAGATTCATCTCGATCTGCTTTTTTAAAGAAATAATTCAAATGATAGCCGACCTTTTTTTCTTCAGGTACCGAGACGTTCCAGTCTGTTAAGAAGCGAAGCTGGAGCAAAGAAGAAGCGGCACCGAAAATCCGTATATGCGTATCGCGCCAATAGCCGAATTTTTTTGTTGTATTTACATATTGATTGGCAATATTGAAACCACCGGTATAACTAATCTTTCCATCGATCACAACGATTTTTCGGTGATCATGGTAATTCAATCGGAAACGAAGTAATGCCCTTTGTGAGGTAACAAATGTATGGACATGTCCACCATTTTTGATTAGACGATTGAAATCTTTTGCTTTTGTGCCATGAGAGCCAAATGCATCATATAATATTCGAACTTCCACGCCTTCTGCGGCTTTTTCTTCTAAAACATGTAAGACTTGCTGGCCGATATTATCTGTCACAAATGCGTAATATTCGATATGGATCGAATGTTTGGCTTTTTTTAGATCTTGAAGCAGTGAATCCAATTTCTCTTGTCCGTCTGTGAGAAGAGTGACAGAATTCATTCTTGTCAGCGGCATACGATTTAATGAAGAGAAGAAGTCAACAAATTGCTGTTTGTCTTTATCGCCCATGTCAGGATCGTAATGTTCAATGGTATCTCCTCTAAAAGACTGAAAGTTTTCTAATTCTTTCAAGTCACTTTGTCGGAGATAGAATTTTTTCTTATCCGTTAATCCACGTCCGAAAAATAAATATAATACAAAGCCCACCCCAGGAAGGGCAAATAATACTAAGAGCCATGCCCAAATGGCTGCTACATCTCGGGGTTTGATCAAAATAGCCACCAAAGCAATAAGTGCATTTAATAGATAAAGGGCGGTTATAATACTAGATACCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"GI": "ALL09868", "sequence": "MVSSIITALYLLNALIALVAILIKPRDVAAIWAWLLVLFALPGVGFVLYLFFGRGLTDKKKFYLRQSDLKELENFQSFRGDTIEHYDPDMGDKDKQQFVDFFSSLNRMPLTRMNSVTLLTDGQEKLDSLLQDLKKAKHSIHIEYYAFVTDNIGQQVLHVLEEKAAEGVEVRILYDAFGSHGTKAKDFNRLIKNGGHVHTFVTSQRALLRFRLNYHDHRKIVVIDGKISYTGGFNIANQYVNTTKKFGYWRDTHIRIFGAASSLLQLRFLTDWNVSVPEEKKVGYHLNYFFKKADRDESKLADTSIQLVSSGPNNEREQIKLSFIKLITSAKKRVWIQTPYLVPDESVIAALKIATASGVDVKIMIPNKPDHPFIYRATQYYARQLIKENVQILVYENGFLHAKTLIMDDEICMVGSANQDIRSYRLNFETSAVIYDPEFLEELATQFKEDETHCSSMTTETVKEMSNWLLFKQQISRLFSPIL"}}}}}}}, "1157": {"$update": {"ARO_description": "VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis"}}, "1098": {"$update": {"ARO_description": "VanB is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with vancomycin resistance, but not teicoplanin resistance."}}, "384": {"$update": {"ARO_description": "APH(2'')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in E. casseliflavus"}}, "1935": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3841": "A74S", "3849": "P102H", "3844": "T80A", "3847": "S95T", "3848": "L109V"}}, "clinical": {"$insert": {"3841": "A74S", "3849": "P102H", "3844": "T80A", "3847": "S95T", "3848": "L109V"}}}}}}}}, "164": {"$update": {"ARO_description": "VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecium"}}, "1849": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["2259", "2258"]}, "clinical": {"$delete": ["2188", "2259", "2258"]}}, "$insert": {"experimental": {"2188": "A91E"}}}}}}}, "_timestamp": "2016-06-16T16:07:12+00:00", "2215": {"$update": {"model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "model_param": {"$delete": ["snp"]}, "model_type_id": "40292"}}, "2083": {"$update": {"model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "model_param": {"$delete": ["snp"]}, "model_type_id": "40292"}}, "_version": "1.0.8", "2109": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3845": "N510D"}}, "clinical": {"$insert": {"3845": "N510D"}}}}}}}}, "1450": {"$update": {"model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "model_param": {"$delete": ["snp"]}, "model_type_id": "40292"}}, "1943": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"3772": "G312S", "3771": "G269S", "3791": "D66N"}}, "clinical": {"$insert": {"3772": "G312S", "3771": "G269S", "3791": "D66N"}}}}}}}}, "824": {"$update": {"ARO_description": "VanD is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance."}}, "2104": {"$update": {"model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "model_param": {"$delete": ["snp"]}, "model_type_id": "40292"}}}, "$delete": ["2239", "2288", "2252", "212", "953", "117", "2286", "2287", "2172", "2173", "2170", "2171", "2169", "2165", "2167", "2161", "2160", "2162"], "$insert": {"2298": {"model_id": "2298", "ARO_accession": "3003793", "model_param": {"blastp_evalue": {"param_value": "1e-60", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Plasmid-mediated SPM metallo-beta-lactamase conferring resistance to carbapenem. Originally isolated from Pseudomonas aeruginosa. Responsible for carbapenem-resistant Pseudomonas aeruginosa (CRPA) outbreaks in Brazil.", "model_sequences": {"sequence": {"3564": {"dna_sequence": {"fmax": "1235", "fmin": "404", "accession": "AJ492820.1", "strand": "+", "sequence": "ATGAACTCACCTAAATCGAGAGCCCTGCTTGGATTCATGGGCGCGTTTTGTTTGTTGCTCGTTGCGGGAGCGCCATTGTCTGCAAAAAGTTCGGATCATGTCGACTTGCCCTACAATCTAACGGCGACCAAGATTGATTCGGACGTTTTCGTCGTCACAGACCGCGATTTCTATTCTTCGAATGTCTTAGTAGCGAAAATGCTTGATGGGACCGTTGTCATTGTCTCTTCGCCGTTTGAAAATCTGGGTACGCAAACGCTTATGGATTGGGTGGCTAAGACTATGAAGCCGAAGAAAGTAGTAGCCATCAATACGCACTTTCATTTGGACGGCACGGGTGGAAATGAAATTTACAAGAAGATGGGCGCGGAGACGTGGTCGAGCGATCTGACAAAGCAGTTGCGACTTGAGGAAAACAAGAAAGACCGGATAAAAGCAGCTGAGTTCTATAAAAACGAGGATCTGAAGCGAAGGATTCTGAGTTCCCATCCTGTTCCAGCGGATAATGTTTTTGATTTGAAACAAGGCAAGGTCTTCTCGTTTTCTAATGAGCTGGTTGAGGTTTCATTTCCAGGACCGGCTCACTCGCCCGATAATGTCGTCGTATATTTTCCCAAGAAGAAACTGCTGTTTGGCGGCTGCATGATAAAGCCGAAGGAACTTGGTTATCTGGGAGATGCCAATGTGAAGGCATGGCCCGATTCAGCTCGGCGGCTAAAAAAGTTTGATGCGAAAATTGTTATACCTGGACACGGCGAATGGGGCGGACCGGAGATGGTTAACAAGACGATCAAGGTCGCGGAAAAGGCCGTTGGCGAAATGAGACTGTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"GI": "CAD37801.1", "sequence": "MNSPKSRALLGFMGAFCLLLVAGAPLSAKSSDHVDLPYNLTATKIDSDVFVVTDRDFYSSNVLVAKMLDGTVVIVSSPFENLGTQTLMDWVAKTMKPKKVVAINTHFHLDGTGGNEIYKKMGAETWSSDLTKQLRLEENKKDRIKAAEFYKNEDLKRRILSSHPVPADNVFDLKQGKVFSFSNELVEVSFPGPAHSPDNVVVYFPKKKLLFGGCMIKPKELGYLGDANVKAWPDSARRLKKFDAKIVIPGHGEWGGPEMVNKTIKVAEKAVGEMRL"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "SPM-1", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40478", "model_name": "SPM-1", "model_type_id": "40292"}, "2292": {"model_id": "2292", "ARO_accession": "3003318", "model_param": {"blastp_evalue": {"param_value": "1e-200", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "point mutation on the Streptomyces rishiriensis parY resulting in aminocoumarin resistance", "model_sequences": {"sequence": {"3557": {"dna_sequence": {"fmax": "40140", "fmin": "38028", "accession": "AF235050.4", "strand": "+", "sequence": "GTGAGTACATTCCCCGCCCCGGCCGCCGGCAGCCGCCCCCAGGACGGCTCCGACTACACCGCACGGCACCTGATGGTGCTCGACGGGCTCGAAGCCGTGCGCAAGCGCCCGGGCATGTACATCGGATCCAGCGACAGCCGCGGTCTGATGCACTGCCTGTGGGAGATCATCGACAACTCCGTGGACGAGGCCCTGGCCGGTGCCTGCGACCACATCGAGGTCATCCTCCACGACGACGGTTCCGTGGAAGTCACCGACAACGGCCGCGGCATCCCCGTGGACACGGAACCCCGCACCGGCCTGTCCGGAGTCGAGCTCGCCTACACCAAACTCCACGCCGGCGGCAAGTTCGGCGGCGGCTCGTACGCCGCCTCCGGCGGCCTGCACGGCGTCGGCGCCTCCGTGGTCAACGCGCTGTCCGCCCGGCTGGACATCGAGGTCGACCGCCACGGCCGCACACACGCCATCAGCTTCCGCCGCGGCGCACCCGGCACCTACTCCGCCCCTGGACCCGACGCCCCCTTCACCCGCGCCCAGGGACTGCACCGGACCGCCAGAATCCCCAAGTCACGGACCGGCACGCGCGTGCGGTACTGGGCCGACCGTCAGATCTTCCTCAAGGACGCCAAGCTCTCCCTGGAGAACCTCCATCAGCGCGCCCGCCAGACGGCGTTCCTGGTGCCGGGCCTGACCATCGTCGTGCGCGATGAGTACGGGCTCGGTGAGGGCGGCAGCAAGGGCGAGGAGTCCTTCCGTTTCGACGGCGGCATCAGCGAGTTCTGCGAGTACCTGGCCGCCGACAAGCCGGTCTGCGACGTCCTGCGCCTCACCGGCCAGGGCACGTTCAAGGAGACGGTCCCGGTCCTGGACGAGCACGGGCAGATGACCCCGACCGAGGTCACCCGCGAGCTCGGCGTGGATGTGGCGCTGCGCTGGGGGACCGGTTACGACACGACGCTGCGGTCGTTCGTCAACATCATCGCCACGCCCAAGGGCGGCACCCATGTCGCCGGGTTCGAGCAGGCCGTGGCCAAGACGATGAACGAGGTGCTGCGGGCCAAGAAGCTGCTGCGCGTCGCGGAGGACGACATCGTCAAGGACGACGCGCTGGAGGGTCTGACGGCCGTCGTCACCGTGCGCCTGGCCGAACCCCAGTTCGAGGGTCAGACCAAGGAGGTCCTGGGCACCTCGGCGGCCCGGCGCATCGTGAACACCGTGATCTCCAGGGAGCTGAAGGCGTTCCTGACCTCCACCAAGCGTGACGCGGCCGCTCAGGCGCGGGTCGTGATGGAGAAGGCGGTCGCCGCCGCGCGCACGCGTATCGCGGCGCGGCAGCACAAGGACGCACAGCGTCGCAAGACGGCGCTGGAGTCCTCGTCCCTGCCCGCCAAGCTGGCCGACTGCCGCAGCGACGACGTCGAGCGCAGCGAACTGTTCATCGTCGAGGGCGACTCGGCGCTCGGTACGGCGAAGCTGGCCCGCAACTCCGAGTTCCAGGCGCTGCTGCCGATCCGGGGCAAGATCCTCAACGTCCAGAAGTCGTCCGTGACCGACATGCTGAAGAACGCCGAGTGCGGGGCGATCATCCAGGTCATAGGGGCGGGCTCCGGGCGGACCTTCGACATCGACGCGGCCCGTTACGGCAAGATCATCATGATGACCGACGCCGATGTGGACGGTTCCCACATCCGGACGCTGTTGCTGACGCTGTTCCATCGCTACATGCGGCCCATGGTCGAGTCGGGCCGGGTGTTCGCCGCGGTGCCGCCGCTGCACCGCATCGAGCTGGTCCAGCCCAAGAAGGGCCAGGACAGGTACGTGTACACGTACTCGGACCGGGAGCTGCGCGACAGGCTCATGGAGTTCCAGAGCAAGGGCGTGAGGTACAAGGACTCCATCCAGCGCTACAAGGGTCTGGGCGAGATGGACGCCGATCAGCTGGCCGAGACGACGATGGACCCGCGTCATCGCACCCTGCGACGCATCAACCTCTCCGACCTGGAGGCCGCCGAGCAGGTCTTCGACCTGCTCATGGGCAACGATGTGGCGCCGCGCAAGGAGTTCATCTCCAGCTCCGCGGCCACGCTGGACCGGTCCAGGATCGATATCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces rishiriensis", "NCBI_taxonomy_id": "68264", "NCBI_taxonomy_cvterm_id": "36876"}, "protein_sequence": {"GI": "AAO47226.2", "sequence": "MSTFPAPAAGSRPQDGSDYTARHLMVLDGLEAVRKRPGMYIGSSDSRGLMHCLWEIIDNSVDEALAGACDHIEVILHDDGSVEVTDNGRGIPVDTEPRTGLSGVELAYTKLHAGGKFGGGSYAASGGLHGVGASVVNALSARLDIEVDRHGRTHAISFRRGAPGTYSAPGPDAPFTRAQGLHRTARIPKSRTGTRVRYWADRQIFLKDAKLSLENLHQRARQTAFLVPGLTIVVRDEYGLGEGGSKGEESFRFDGGISEFCEYLAADKPVCDVLRLTGQGTFKETVPVLDEHGQMTPTEVTRELGVDVALRWGTGYDTTLRSFVNIIATPKGGTHVAGFEQAVAKTMNEVLRAKKLLRVAEDDIVKDDALEGLTAVVTVRLAEPQFEGQTKEVLGTSAARRIVNTVISRELKAFLTSTKRDAAAQARVVMEKAVAAARTRIAARQHKDAQRRKTALESSSLPAKLADCRSDDVERSELFIVEGDSALGTAKLARNSEFQALLPIRGKILNVQKSSVTDMLKNAECGAIIQVIGAGSGRTFDIDAARYGKIIMMTDADVDGSHIRTLLLTLFHRYMRPMVESGRVFAAVPPLHRIELVQPKKGQDRYVYTYSDRELRDRLMEFQSKGVRYKDSIQRYKGLGEMDADQLAETTMDPRHRTLRRINLSDLEAAEQVFDLLMGNDVAPRKEFISSSAATLDRSRIDI"}}}}, "ARO_category": {"36631": {"category_aro_name": "gene involved in self resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}, "36616": {"category_aro_name": "aminocoumarin resistance gene", "category_aro_cvterm_id": "36616", "category_aro_accession": "3000477", "category_aro_description": "Point mutations to DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. In some cases, expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can also confer aminocoumarin resistance. Aminocoumarin efflux pump exists that export the drug out of the cell to confer resistance"}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39902", "model_name": "Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin", "model_type_id": "40292"}, "2303": {"model_id": "2303", "ARO_accession": "3003801", "model_param": {"blastp_evalue": {"param_value": "1e-60", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene", "model_sequences": {"sequence": {"3570": {"dna_sequence": {"fmax": "5980365", "fmin": "5979156", "accession": "CP012901.1", "strand": "-", "sequence": "TCAACGGTTTCCGCCGTGCAGGGCCAAGCCCAGCGCGAGCAGGCTGCCGACGCCGCAGACGGCCATCACCAGCGCCATCGGCAGCACGCCGGGCAGCGCCAGCCAGCCGACCGCCAGGCTGGCCAGGCAGCCGAGGCCGAACTGCCCGGACACCGCCACCGCCGAAGCCGCCCCGGCCTGTCCGGGATACAACGCCAGCAGGCTGGCGATGCAGTTGGCGCCGAGCAGGCCGGTGACGCTGACGAAGCACAGCAGGCCGGGCACCAGCGCCCACAACCCGCCCCGCTCGCCGAGCGCCGCATAGCCGAGGAGGAACAGCCCGGACACGCAGGCCAGCAGGCTGCCGGCCCGCAGCAGCGGCCGCGGACCGTGGCGGCGCACCAGGCGCGCGCTGCACCAGGTGGCGAGCATCACGCCGAGGATGTTCAGGCCGAAGAACCAGCCGAAGCGCTCCGCGCGCACGCCGAAATGCTCGATGAACACGAAGGGCGCGGCGCTGATGTAGGCGAACATCCCGGCGAACGCCAGCCCCATGCACAGCACGTAGCCCAGCGCGCGACGGTCGCCGAGCAGCCGCCCATAGGCGAGAAAGGCCTGGGCCAGGCTGCCGCCGCGGCGCTCCGGCGGGTGGCTTTCGGCGACCCGCCAGACCGCCAGCAGGCAGAGCCCGGCGAACAGCGCCAGGACCACGAACAACGCGCGCCAGCCGGCCCAGAGCATCAGGTAGCCGCCGAGCAGCGGCGCGGCCAGCGGTGCCAGCATGGTCACCATGTGCATCAATGCCAGCATCCGGGCGGCCTCGCCCAACGGATAGAGGTCGCGCACCATGGCCCGCGCCAGCACCGACGCGGCGCCGCCGCCGAGGGCCTGGAGCACCCTCAGCAGGACCAGTTGCCCCGCGCTGTCGGCCAGCGCGCAGGCCAGGCTGCTGAACAGGTACAAGGCGATACCGGCCAGCAGCACCGGGCGCCGGCCGAAACGGTCGGACAAGGGGCCGTAGAACAGCATGCCGACGCAGAAGCCGACCAGGAAGCCGCTGATGCTCCGCTGCACCTGGGCATCGCTGGCGCCGAGATCGGCGGCGATCGCCGGCAGGCTCGGCAGGTACATGTCGATCGACAGCGGGCCGAACGCCACCAGCGCCGACAACAGCAGCAACAGGCGTCGTTCGCCGCTTCCGACCTGAATCCTCGATGCACTCGCAGGCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"GI": "ALV80601.1", "sequence": "MPASASRIQVGSGERRLLLLLSALVAFGPLSIDMYLPSLPAIAADLGASDAQVQRSISGFLVGFCVGMLFYGPLSDRFGRRPVLLAGIALYLFSSLACALADSAGQLVLLRVLQALGGGAASVLARAMVRDLYPLGEAARMLALMHMVTMLAPLAAPLLGGYLMLWAGWRALFVVLALFAGLCLLAVWRVAESHPPERRGGSLAQAFLAYGRLLGDRRALGYVLCMGLAFAGMFAYISAAPFVFIEHFGVRAERFGWFFGLNILGVMLATWCSARLVRRHGPRPLLRAGSLLACVSGLFLLGYAALGERGGLWALVPGLLCFVSVTGLLGANCIASLLALYPGQAGAASAVAVSGQFGLGCLASLAVGWLALPGVLPMALVMAVCGVGSLLALGLALHGGNR"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "bcr-1", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40486", "model_name": "bcr1", "model_type_id": "40292"}, "2290": {"model_id": "2290", "ARO_accession": "3003784", "model_param": {"blastp_evalue": {"param_value": "1e-110", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance.", "model_sequences": {"sequence": {"3555": {"dna_sequence": {"fmax": "1474242", "fmin": "1472985", "accession": "HE608151", "strand": "+", "sequence": "GTGGCCGAGCGTTTCGTCGTGACTGGGGGCAACCGGTTATCAGGCGAAGTGGCCGTCGGCGGCGCCAAGAACAGCGTGCTCAAGCTCATGGCTGCGACGTTGTTGGCCGAGGGCACCAGCACGATCACCAACTGTCCCGACATCCTCGATGTGCCGCTGATGGCGGAGGTACTGCGTGGTCTGGGCGCCACCGTCGAACTCGACGGTGACGTGGCCCGGATCACCGCACCTGACGAGCCGAAGTACGATGCCGACTTCGCTGCGGTGCGGCAATTCCGCGCCTCGGTCTGTGTGCTGGGACCGCTGGTCGGGCGGTGCAAACGGGCCAGGGTCGCGCTGCCGGGCGGTGACGCGATCGGGTCGCGTCCGTTGGATATGCACCAGGCGGGCCTACGGCAATTGGGTGCCCACTGCAACATCGAGCACGGCTGCGTGGTAGCCCGAGCGGAAACGTTGCGCGGTGCGGAGATTCAGTTGGAGTTCCCCTCGGTGGGAGCCACCGAGAACATCTTGATGGCCGCCGTGGTGGCCGAGGGAGTCACCACTATTCACAATGCGGCTCGAGAACCCGACGTCGTCGACTTGTGCACGATGTTGAACCAGATGGGCGCACAGGTCGAAGGTGCGGGTTCGCCGACAATGACCATCACCGGTGTCCCGCGGCTGCATCCAACCGAGCACCGGGTGATCGGAGACCGTATCGTTGCCGCCACATGGGGCATCGCTGCCGCAATGACCCGTGGTGATATATCAGTGGCGGGCGTAGACCCGGCGCATCTGCAGCTGGTGCTGCACAAATTGCACGACGCGGGCGCAACCGTCACCCAGACTGACGCCAGCTTCCGGGTGACCCAGTACGAGCGTCCGAAGGCTGTCAACGTTGCGACCTTGCCGTTCCCCGGGTTTCCCACGGATCTGCAGCCGATGGCTATCGCTTTGGCGTCGATCGCCGACGGCACATCGATGATCACGGAGAACGTGTTCGAGGCGCGGTTCCGCTTCGTTGAAGAGATGATCCGGCTCGGTGCAGACGCTCGGACCGACGGGCACCACGCCGTGGTGCGGGGCCTCCCGCAGCTGTCGAGCGCTCCGGTGTGGTGTTCGGACATCCGTGCCGGGGCCGGCTTGGTGCTGGCGGGGCTCGTTGCCGACGGCGACACCGAGGTCCACGATGTATTCCACATCGATCGCGGATATCCGTTGTTCGTGGAGAACCTGGTGAGTCTCGGTGCCGAGATCGAACGGGTATGCTGTTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis UT205", "NCBI_taxonomy_id": "1097669", "NCBI_taxonomy_cvterm_id": "40468"}, "protein_sequence": {"GI": "CCE36834", "sequence": "MAERFVVTGGNRLSGEVAVGGAKNSVLKLMAATLLAEGTSTITNCPDILDVPLMAEVLRGLGATVELDGDVARITAPDEPKYDADFAAVRQFRASVCVLGPLVGRCKRARVALPGGDAIGSRPLDMHQAGLRQLGAHCNIEHGCVVARAETLRGAEIQLEFPSVGATENILMAAVVAEGVTTIHNAAREPDVVDLCTMLNQMGAQVEGAGSPTMTITGVPRLHPTEHRVIGDRIVAATWGIAAAMTRGDISVAGVDPAHLQLVLHKLHDAGATVTQTDASFRVTQYERPKAVNVATLPFPGFPTDLQPMAIALASIADGTSMITENVFEARFRFVEEMIRLGADARTDGHHAVVRGLPQLSSAPVWCSDIRAGAGLVLAGLVADGDTEVHDVFHIDRGYPLFVENLVSLGAEIERVCC"}}}}, "ARO_category": {"36410": {"category_aro_name": "fosfomycin resistance gene", "category_aro_cvterm_id": "36410", "category_aro_accession": "3000271", "category_aro_description": "Genes conferring resistance to fosfomycin."}}, "ARO_name": "Mycobacterium tuberculosis murA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40467", "model_name": "Mycobacterium tuberculosis murA", "model_type_id": "40292"}, "2294": {"model_id": "2294", "ARO_accession": "3003789", "model_param": {"blastp_evalue": {"param_value": "1e-200", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"3817": "T86I"}, "clinical": {"3817": "T86I"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Campylobacter jejuni is a major bacterial infectious agent associated with gastroenteritis. Quinolone resistance is reportedly conferred by a single C-257-T nucleotide substitution in the gyrA gene.", "model_sequences": {"sequence": {"3559": {"dna_sequence": {"fmax": "960222", "fmin": "957630", "accession": "NC_002163.1", "strand": "-", "sequence": "TTATTGCAAATCTAAACCAAAGTTTTCATCGCTTAACTCATCCTCGTCATTTTCCTCTTTAGGACACTTAGCGATGCTAACCACCTCGTCATTTTCCACATTAACTACAATGACACCACTCGTATTACGCCCTGCTTTTCTAATGCTTTGCATATCAACACGTATCATCTTACCTGAACTTGTAAGAGCCATTAAATCCATAGTTTCATCTACTATAACTACGCTAATAAGATCTTTGGTTTTTTCTGTAAGTTTCATACAAATTACACCCTTACCACCTCTGCTTTGCAATCTATATTCTCCAGCATTGGTGCGTTTTCCTATACCTTTTGCACTTATGCTTAAAATTTCTTGCTCATCATTTTCTATAACAACTGCACCTACTAATTCGTCATTTTTCTCTTTAAACTTAATAGCCGTCACCCCACGACTTACACGGCCGATTTCACGCACTTTAGCAAGTGGGAATTTGATACACATACCTTTTTTGGTTACTGCAAAGAGCATTTTACCTTGTGTGCTTACACTTTCTTCATTTTCAAGATTTTCATCATCTAAATTTTCAATTTCTTGATTTTCTAAATTTTCTTCACCACCAGTGGCAAAAATTTCATCTTCATCTCTTTGAACAATAATAGCAGTTACCAACTCATCATTTTCATCCAAGTTGATCGCTCTAACTCCTACACTTCTGATATTTTGATATTCACTCAAATTTGTACGCTTTACAATACCATTTTTAGTAAAGAAACATAAAGATTTGCTCTCATCAAAATCCGTGGTTGGAATAATAGCCATGATTTTTTCTTCAGCTTGTAAATTGATAAGATTTACCACTGCTTTTCCTTTAGCCGTTCTTGAGCCTTCAGGAATTTTATAAACTTTAAGCCAATAAAGCTGTCCACGATCTGTTACAAACATAAGCGTATCATGTGTATTTGCCGTAAAGAAACTTTCTATAAAATCATCATCATAAGTCGTAACGGCTAATTTTCCTTTTCCACCTCGTTTTTGTTTTTCATATTGTTTACTAGGCACACGCTTAATATAACCACGATGTGTGATAGTTACAACCATATTTTCATTAGGAATCAAATCTTCAATATCAATATCATCGTAATCATCTTCAATTTGAGTAATACGTGGCACATCAAATTTACTTCTAATTTCTTTTAATTCATCGCGAATTAAATTTTCAAGCAAGGTTTCACTTTTTAAAATTTCTTCAAGTCTTGCAATTTCTTTCATTAATTCTGCAAGTTCATTTTCGATTTTTTCTCTTTCAAGTCCTGTTAAACGACCAAGTTTCATATCTAAAATAGCATTGGCTTGAAGCTCACTAAGACCAAATTTAGCTACTAAAGAATCTCTTGCGGTATTATTATCAGAACTATTTTTAATTAAAGCAATCACTTCATCTATATTATCAAGTGCAATTTTAAGACCTTCTAAAATATGAGCTCTTGCTCTTGCCTTTTGAAGTTCAAAAATCGTTCTTCTAATAATAACTGTTTTTCTATGAGTTAAGAAAAGATTTAAAAGTTCCAACAAAGAGAAAATTTTAGGTTCTTTATTATGAATTGCCAACATAATCACACCAAAAGTACTTTCCATAGTGGTAGATTTAAATAGATTATTTAAAACAATTTCACTCATAGCCTCACGTTTAAGCTCTATAACAACGCGGATTCCTTCTTTATTGCTCTCATCTCTTACTTCAGATATTCCTTCAATTTGCCTTTCTTTAACAAGCTCTGCAATCTGCTCTATAAGCCTAGCTTTATTGGTTTGATAAGGAAGCTCATCGATAACAATAACATCTTTATTTGTCTTTTTTTCAATATGAGTTTTAGCTCGCACTTTCACGCGACCACGCCCTGTGCGATAAGCTTCTATAATACCTTTTTTACCATAAATTATTCCACCTGTTGGAAAATCTGGACCTTTGATAAACTGCATAATCTCTTCTAGGCTTGCATCTTTATTATCAAGCAAATATAAAAGTCCATCTATCAACTCATTTAAACTATGAGGTGGGATGTTTGTCGCCATACCTACAGCTATACCACTTGAACCATTTAATAATAAATTTGGAACCCTAGAAGGTAAAACATCAGGTTCGCTTTCTGAACCATCATAATTTGGAACAAAATCGACCGTATCTTTATCTATATCTTTTAAAAGCTCATGAGAAAGTTTACTCATTTTTGCTTCAGTATAACGCATCGCAGCGGCACTATCACCATCTATAGATCCAAAGTTGCCTTGTCCTGTAATACTTGGATATCTCATAGAAAAATCTTGAGCCATTCTAACCAAAGCATCATAAACTGCTGTATCTCCATGTGGGTGATAACGACCTATAACAGCACCCACTATACGGGCTGATTTGACAAAATCTGTTCTACTTTTTGCCTCATCATTTTGCATAGCATATAAAATTCTTCTATGAACAGGCTTTAAACCATCTCTTGCGTCAGGCAAAGCACGACCTATAATAACACTCATAGAATAGTCTAAATAACTACTTTTTATAGAATTTTCTATATCTACAAGTTCAATATCAGAATCTTTGCTAAAAATATTCTCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Campylobacter jejuni subsp. jejuni NCTC 11168", "NCBI_taxonomy_id": "192222", "NCBI_taxonomy_cvterm_id": "36956"}, "protein_sequence": {"GI": "YP_002344422.1", "sequence": "MENIFSKDSDIELVDIENSIKSSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEAKSRTDFVKSARIVGAVIGRYHPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSAAAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPDVLPSRVPNLLLNGSSGIAVGMATNIPPHSLNELIDGLLYLLDNKDASLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGRGRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKERQIEGISEVRDESNKEGIRVVIELKREAMSEIVLNNLFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRKTVIIRRTIFELQKARARAHILEGLKIALDNIDEVIALIKNSSDNNTARDSLVAKFGLSELQANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKFDVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTYDDDFIESFFTANTHDTLMFVTDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMAIIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSVGVRAINLDENDELVTAIIVQRDEDEIFATGGEENLENQEIENLDDENLENEESVSTQGKMLFAVTKKGMCIKFPLAKVREIGRVSRGVTAIKFKEKNDELVGAVVIENDEQEILSISAKGIGKRTNAGEYRLQSRGGKGVICMKLTEKTKDLISVVIVDETMDLMALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSIAKCPKEENDEDELSDENFGLDLQ"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Campylobacter jejuni gyrA conferring resistance to fluoroquinolone", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40474", "model_name": "Campylobacter jejuni gyrA conferring resistance to fluoroquinolone", "model_type_id": "40293"}, "2291": {"model_id": "2291", "ARO_accession": "3003785", "model_param": {"blastp_evalue": {"param_value": "1e-80", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Chlamydia murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 119 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance.", "model_sequences": {"sequence": {"3556": {"dna_sequence": {"fmax": "1335", "fmin": "0", "accession": "AY152390", "strand": "+", "sequence": "ATGCCTGGTATCAAGGTTTTTGGAGAAACGGTCTTAAGAGGATCTGTGCGCGTGTCAGGAGCTAAAAATGCTACAACTAAATTACTTGTAGCCTCCTTACTTTCGGATCAGCGAACGATTTTAAAGAACGTCCCTAATATTGAAGATGTTCGGCAAACGGTAGATCTTTGTCGGGTTTTAGGGGCGATTGTAGAGTGGGATCAGCAAGCGCAAGTGATTGAAATTCACACTCCGCGCATTTTATTGTCCAAGGTTCCTCCGCAATTTTCTTGTGTTAATCGGATTCCTATTTTGCTGTTAGGAGCGTTGTTACGTCGTTGTCCTTATGGGATTTTTGTTCCTATTTTGGGAGGGGATGCTATAGGACCTCGTACGCTACATTTCCATTTAGAAGGATGGAAGAAGCTTGGAGCAGAGATAGTAATTAGTGATGAAGGCTATTGGGCTTCAGCTCCAAATGGTCTTGTTGGAGCACACATCACGTTACCCTACCCTTCTGTGGGAGCCACAGAAAACCTCATCCTTGCTTCTGTAGGGGCTCAAGGACGAACGATTATTAAGAATGCTGCTCTTGAAGTGGAAATCATTGATTTGATTGTCTTTTTACAGAAAGCAGGCGTGGAGATTACAACAGATAATGATAAGACCATCGAAATTTTTGGATGTCAGGATTTCTATTCTGTTGAGCACTTCATTATTCCAGATAAAATCGAGGCTGCTTCTTTCGGTATGGCTGCGGTAGTTTCTCAGGGAAGGATCTTCGTAGAACAAGCGCGCCATGAGCATATGATCCCTTTTTTAAAGGTATTAAGATCGATAGGAGGGGGATTCTCTGTACATGAGAATGGGATCGAATTTTTCTACGATAAGCCTTTGAAAGGGGGTGTTCTTCTAGAAACGGATGTGCATCCAGGGTTTATTACAGATTGGCAACAACCTTTTGCCGTATTGCTCTCTCAGTCAGAAGGTTGTTCGGTGATCCATGAGACAGTGCATGAGAATCGTCTTGGGTATTTGAAAGGTTTGGTAAAAATGGGAGCGCATTGTGATTTATTTCACGAGTGTTTGAGTGCTAAGTCGTGTCGCTATTCTACAGGGAATCATCCTCATAGCGCAGTCATTCATGGTCCGACTCCTTTGCAGGCAACAGACTTAGTGATTCCTGATTTGCGCGCAGGATTTGCTTATGTCATGGCCGCACTCATTGCAGAAGGCGGAGCCTCATGGATTGAGAATACCGAGATGCTGGATCGAGGGTACACTGATTGGCGAGGGAAATTAGAAAGATTAGGAGCTAAGGTTTTAGCGCGAGACGCAGTATCTGTGTATGTTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Chlamydia trachomatis", "NCBI_taxonomy_id": "813", "NCBI_taxonomy_cvterm_id": "40470"}, "protein_sequence": {"GI": "AAN28945", "sequence": "MPGIKVFGETVLRGSVRVSGAKNATTKLLVASLLSDQRTILKNVPNIEDVRQTVDLCRVLGAIVEWDQQAQVIEIHTPRILLSKVPPQFSCVNRIPILLLGALLRRCPYGIFVPILGGDAIGPRTLHFHLEGWKKLGAEIVISDEGYWASAPNGLVGAHITLPYPSVGATENLILASVGAQGRTIIKNAALEVEIIDLIVFLQKAGVEITTDNDKTIEIFGCQDFYSVEHFIIPDKIEAASFGMAAVVSQGRIFVEQARHEHMIPFLKVLRSIGGGFSVHENGIEFFYDKPLKGGVLLETDVHPGFITDWQQPFAVLLSQSEGCSVIHETVHENRLGYLKGLVKMGAHCDLFHECLSAKSCRYSTGNHPHSAVIHGPTPLQATDLVIPDLRAGFAYVMAALIAEGGASWIENTEMLDRGYTDWRGKLERLGAKVLARDAVSVYV"}}}}, "ARO_category": {"36410": {"category_aro_name": "fosfomycin resistance gene", "category_aro_cvterm_id": "36410", "category_aro_accession": "3000271", "category_aro_description": "Genes conferring resistance to fosfomycin."}}, "ARO_name": "Chlamydia trachomatis murA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40469", "model_name": "Chlamydia trachomatis murA", "model_type_id": "40292"}}}