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{"model_sequences": {"$update": {"sequence": {"$update": {"1155": {"$update": {"protein_sequence": {"$update": {"GI": "CAL08007.1"}}}}}}}}}}, "961": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1877": {"$update": {"protein_sequence": {"$update": {"GI": "ABN49110.1"}}}}}}}}}}, "962": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1533": {"$update": {"protein_sequence": {"$update": {"GI": "AGW83454.1"}}}}}}}}}}, "963": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1022": {"$update": {"protein_sequence": {"$update": {"GI": "AGE45504.1"}}}}}}}}}}, "968": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1503": {"$update": {"protein_sequence": {"$update": {"GI": "AIT76104.1"}}}}}}}}}}, "969": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1805": {"$update": {"protein_sequence": {"$update": {"GI": "AGH33739.1"}}}}}}}}}}, "2108": {"$update": {"ARO_description": "Sequence 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{"model_sequences": {"$update": {"sequence": {"$update": {"3243": {"$update": {"dna_sequence": {"$update": {"accession": "NC_008596.1"}}}}}}}}}}, "2100": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3272": {"$update": {"dna_sequence": {"$update": {"accession": "NR_114659.1"}}}}}}}}}}, "2107": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2132": {"$update": {"protein_sequence": {"$update": {"GI": "AAC44548.1"}}}}}}}}}}, "2106": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3246": {"$update": {"dna_sequence": {"$update": {"accession": "NC_008596.1"}}}}}}}}}}, "2105": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3255": {"$update": {"dna_sequence": {"$update": {"accession": "CU458896.1"}}}}}}}}}}, "2104": {"$update": {"model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. 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In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}, "model_type_id": "40293"}}, "635": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1532": {"$update": {"protein_sequence": {"$update": {"GI": "AGW16414.1"}}}}}}}}}}, "1560": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1448": {"$update": {"protein_sequence": {"$update": {"GI": "CAP12360.2"}}}}}}}}}}, "641": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1736": {"$update": {"protein_sequence": {"$update": {"GI": "AAD19217.1"}}}}}}}}}}, "878": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1105": {"$update": {"protein_sequence": {"$update": {"GI": "AGW25368.1"}}}}}}}}}}, "879": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1799": {"$update": {"protein_sequence": {"$update": {"GI": "AEG64812.1"}}}}}}}}}}, "876": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"564": {"$update": {"protein_sequence": {"$update": {"GI": "CAC14595.1"}}}}}}}}}}, "877": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1851": {"$update": {"protein_sequence": {"$update": {"GI": "ACV32634.1"}}}}}}}}}}, "874": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"51": {"$update": {"protein_sequence": {"$update": {"GI": "ADH03009.1"}}}}}}}}}}, "875": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"716": {"$update": {"protein_sequence": {"$update": {"GI": "CAC81324.1"}}}}}}}}}}, "872": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"211": {"$update": {"protein_sequence": {"$update": {"GI": "AAC61671.1"}}}}}}}}}}, "643": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1467": {"$update": {"protein_sequence": {"$update": {"GI": "CAG34107.1"}}}}}}}}}}, "870": {"$update": {"model_sequences": {"$update": 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MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_414618.4", "sequence": "MPEVQTDHPETAELSKPQLRMVDLNLLTVFDAVMQEQNITRAAHVLGMSQPAVSNAVARLKVMFNDELFVRYGRGIQPTARAFQLFGSVRQALQLVQNELPGSGFEPASSERVFHLCVCSPLDSILTSQIYNHIEQIAPNIHVMFKSSLNQNTEHQLRYQETEFVISYEDFHRPEFTSVPLFKDEMVLVASKNHPTIKGPLLKHDVYNEQHAAVSLDRFASFSQPWYDTVDKQASIAYQGMAMMSVLSVVSQTHLVAIAPRWLAEEFAESLELQVLPLPLKQNSRTCYLSWHEAAGRDKGHQWMEEQLVSICKR"}}}}, "ARO_category": {"36547": {"category_aro_name": "sulfonamide resistance gene", "category_aro_cvterm_id": "36547", "category_aro_accession": "3000408", "category_aro_description": "Genes conferring resistance to sulfonamide antibiotics."}, "36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}}, "ARO_name": "leuO", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40537", "model_name": "leuO", "model_type_id": "40292"}, "2331": {"model_id": "2331", "ARO_accession": "3003841", "model_param": {"blastp_evalue": {"param_value": "1e-130", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding.", "model_sequences": {"sequence": {"3608": {"dna_sequence": {"fmax": "721733", "fmin": "721055", "accession": "NC_000913.3", "strand": "-", "sequence": "TCAAAGCATAAACCGATAGCCAATACCGGTTTCAGTAATGAAATGGCGTGGGCGGGCGGGATCCTGTTCCAGTTTTTGTCGCAGATGTCCCATATAAATACGCAAATAGTGACTGTGTTCGACCGCGTTTGGCCCCCACACCTGGTTAAGGAGCTGGCGCTGGGTGAGTACTTTTCCGGCATTGTTGAGCAGCACCGCCAGCAGGCGGAACTCAATTGGTGTGAGATGCACCTCTTCCTCACCCCGGTGAATCACGCGGGCGGCTAAATCGACGGTAACATCGGAAAATTTTACCAGCGGATCGGGCGCGGTGGTGGCAGAGTGGCGGCGTAATGCGACGCGCAGACGGGCCTGCAATTCGCCAATGCCAAACGGCTTACTCAGATAATCATCCGCTCCGGCATCCAGCGCGGCGATTTTGTCGCTCTCTTCGCTGCGTGCGGAAAGCACAATCACCGGCACCGCGCTCCACTGGCGCAGGTCGCGGATAAACTCAATCCCATCACCATCGGGCAGGCCGAGATCGAGAATAATCAAATCTGGCTTACGGGTTGCCGCTTCCAGCAAGCCGCGTTGCAGCGTTTCGGCCTCAAAGACGCGCATCCCGTCGCCCTCCAGCGCCGTGCGCAGAAAGCGACGAATAGCCTGTTCATCTTCAACAATCAGAACGTTTGTCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_415222.1", "sequence": "MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAVPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATTAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRFML"}}}}, "ARO_category": {"36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}}, "ARO_name": "kdpE", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40534", "model_name": "kdpE", "model_type_id": "40292"}, "2332": {"model_id": "2332", "ARO_accession": "3003844", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor, is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions.", "model_sequences": {"sequence": {"3609": {"dna_sequence": {"fmax": "1173964", "fmin": "1170517", "accession": "NC_000913.3", "strand": "-", "sequence": "TTAAGCGATCGCGTTCTCTTCCAGTTCACGCATAAACTGGCGTACCCATTCGATACGCGTTTTCCGCTCACTCAAATCCTGAATAAATTTCAGGCGCGTCGGACCATCAAGGCGGTAATGCTGCGGCTGTTTTTGCAGCAAACCAATCAACCAGGCCGGATTAACGTGATTCTTCTCGGCAAATTCGATCACCCCGCCTTTCTCATTACCTTCCAGCTTCCTGATCCCCAGTTTCTGCGCTTGCTGGCGCAGACGGGCAATATCCAGCAGGGTACGCGCCGGATCTGGCAGCAGGCCGAAGCGATCGATAAGCTCGACTTTGATCTCTTCCAGTTCGTTTTCCGTTTTGGCGCTGGCAATACGTTTGTAGAACGACAGACGCGTGTTCACGTCAGGGATGAAATCATCTGGCAATAGCGACGGCATCCGCAGCTCGACTTCTGTTTGCTGGCTGGTGAGATCTTCCAGCGACGGCTCGCGTCCGGCTTTCAGTGCATCGACGGCGTTTTCCAGCAACTCCATATACAGCGAGAAACCGATGGTTTCCATTGAGCCGCTTTGTTCTTCGCCAAGCAGTTCACCCGCGCCGCGAATCTCCAGATCGTGCGTTGCCAGCGCAAAACCTGCCCCGAGATCTTCCAGCGAGGCAATTGCTTCAAGACGTTTTTGTGCATCGGTAGTCATCGCTTTTGGATGCGGTGTCAGCAACCATGCATATGCCTGATGATGCGAACGTCCGACGCGACCGCGTAACTGGTGCAGCTGCGCCAGACCGAAGTGATCCGCGCGTTCAATGATAATAGTGTTGGCTGTCGGGATGTCGATCCCGGTTTCGATAATGGTTGTACAAACCAGCACGTTGAAACGTTGATGATGGAAATCATTCATCACCCGTTCCAGTTCGCGCTCGCGCATCTGCCCGTGACCGATGGCGATCCGCGCTTCTGGCACCAGTTCTGCCAGCCGTTCGGCGGCTTTCTGAATGTTTTCCACATCATTGTAGAGATAATAAACCTGTCCTCCGCGCAAAATTTCACGCAGGATCGCCTCCCGGACCACCATGCTGTCATACTCACGGACAAAGGTTTTAACTGCCAGACGACGGGCGGGCGGCGTGGCGATAATCGACAGGTCACGCATTCCGCTCATTGCCATATTCAGCGTACGTGGGATCGGCGTTGCAGTAAGCGTCAGAATATCCACGTTCGCGCGCATCGCTTTAATGCGCTCTTTATGACGCACCCCGAAGCGGTGTTCTTCATCGACAATCAGCAGGCCTAAATCTTTAAACTTGACGTCACTTTGCAGCAGTTTGTGCGTACCGATCAGAATATCGATTTTCCCTTCCGCCACTTCCGCAAGGATTTGCGTCTGCTCTTTGGCGCTGCGGAAACGGGAGATCATTTCGATACGTACCGGCCAGTTGGCGAAACGGTCGCGGAAGTTGTCGTAATGCTGCTGCGCGAGAAGGGTGGTAGGCACCAGCACCGCCACCTGCTTGTGGTTATCTACTGCCAGGAAAGCTGCGCGCATCGCCACTTCTGTTTTACCAAAGCCAACATCGCCGCACACCAGACGATCCATTGCCAGCGGCTGACACATGTCGCTAAGTACCGCATTAATGGCCTGCGCCTGATCCGGCGTGGTTTCAAACGGGAAGCTGTCGCAGAACAACTGATACTGCTCACGATCGTGTTTAAACGCGAAGCCCTCTTTGGCGGCGCGTTGCGCGTAGATATCCAGCAATTCCGCCGCCACATCACGCACTTTTTCCGCCGCTTTCTGCCGCGCGCGTGACCACGCATCGCCGCCAAGTTTATGCAGCGGGGCGTTTTCTTCCGCGCCACCTGCGTAACGGCTAATCAGATGCAGTGACGACACCGGAACATACAGTTTGGCGTCGTTGGCATAGGTGAGCATCAGATACTCGCCAGTAATGCCACCCGCTTCCAGCGTGGTCATTCCGGCATAACGACCGACGCCGTGCTCCAGATGGACCACCGGCTGACCAATATGCAGTTCCGCAAGGTTACGGATCAGTGTATCGGGGTTGATGGTGCGGCGAGAATCCTGACGACGACGGGCAACGCGTTCACCGAGCAGATCGCTTTCGCAAATCAGCGCCAGATTACGCACCGTATCGACAAAACCATGTTCGGCAGCGCCAATCATCAGATAACGCCCACGGTCGCTGGCTTCATCAAGACGCATAATGCGTTGCGGAGCAATTTTAATTCGTGCGAGCAGTTCACCCAGCGCTTCACGGCGACCTTCACTTTCTACCGAGAACACCACCGGACCGTCGAAAGTCTCGAGGAACTTACGCAGCGCATCCAGCGGCGCTTTTTGTTGTGCCTGAACGGCCAGGTCTGGCAGTTTCTGGAAACCTAAATTGGCATTCGCGGCTTTTGTCGGTAAATGTTCAGTTTTTAGCTGCACCCGGGGCCAGTTTTTCAGCTCTGAGAAGAGCTCGTCCACCCGCAGCCAGAGCGATTGTGGTGGCAACAGCGGGCGCATCGGATCGACGCCGCGATTCTCAAAACGCGCCAGCGTGTCAGCCTGGAAACGTTCGGCACTGGTTTCCAGATCGCCAGTATTCACGAGCAAGGTATTGGCAGGGAAATAACTGAACAGCGGCGGCAGTGGTTCGCTGAAGAACAATGGCTGCCAGTACTCGATCCCGGCAGGTAATGTGCCTTTACTCACTTGCTGGTAAATATGTTCTGGATCGCGCTTCACTTCGAAGGTATCGCGCCACTGGCTGCGGAACAGTTCAATTGCCGCTTTATCGGTCGGAAATTCGTGCGCGGGCAGCAGATTGATCGCTTCTACTTCCTCCAGCGTGCGCTGGCTGTCGACGTCAAACACCCGCAGGCTGTCGATTTCATCATCAAAGAAATCAAGACGATAAGGCAGCTCACTCCCCATCGGGAAGAGATCCAGCAACGCGCCGCGCGTGGCGTATTCGCCGTGCTCCATCACCTGGTCAACATGGCGATAACCGGCGCTGTCCAGTTGGGTTCGTAATGCATCTCGTGACAGGCGCTGACCTTTTTTCATCACCAGCGCATGACCGTGGAGAAAACTGTGTGGGCAAACGCGCTGCATAAGCGTATTCACCGGAACAATCAGTACGCCACGCTGCATCGTCGGTAGCTGGTAAAGGGTGGAAAGGCGCGAGGAGATAATGTCCTGATGAGGCGAAAAACTGTCGTAGGGAAGAGTTTCCCAGTCCGCCAGATTCATCACCATTTGATCGGTAAACTGGCTGATTTCATCATGCAAACGCAGAGCATTTTGCATATCTGGTGCAATGAGTACCACCGGACCGGCGTGACGTTCGGCAATTTCCGCTACCAGCGTTGCACAGGCTGCGCCGGTTAACTCGCCCAGCAGACGCTGCTCACCCGCTTTGACGGGCAGCGTATAACGATATTGTTCAGGCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_415632.1", "sequence": "MPEQYRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALRLHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQRGVLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHVDQVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTLEEVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTLPAGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARFENRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANLGFQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLARIKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGERVARRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLEAGGITGEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAWSRARQKAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTPDQAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHKQVAVLVPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVAEGKIDILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVDILTLTATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVREAILREILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERVMNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRVGRSHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIRGAGELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTEVELRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLLPDPARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGLLQKQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAIA"}}}}, "ARO_category": {"36324": {"category_aro_name": "antibiotic target protection protein", "category_aro_cvterm_id": "36324", "category_aro_accession": "3000185", "category_aro_description": "These proteins confer antibiotic resistance by bind the antibiotic target to prevent antibiotic binding."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "mfd", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40538", "model_name": "mfd", "model_type_id": "40292"}, "2333": {"model_id": "2333", "ARO_accession": "3002474", "model_param": {"blastp_evalue": {"param_value": "1e-130", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "LEN-26 is a beta-lactamase found in Escherichia coli and Klebsiella pneumoniae.", "model_sequences": {"sequence": {"3610": {"dna_sequence": {"fmax": "861", "fmin": "0", "accession": "NG_049281", "strand": "+", "sequence": "ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCAACCTGCCACTAGCGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGGTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTGACCGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACATGCGCGACACCACTACCCCGGCCAGCATGGCCGCCACGCTGCGTAAACTACTGACTGCGCAGCATCTGAGCGCCCGTTCACAGCAGCAGCTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGACAAGACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGCATTGTGGTGATTTATATGCGGGATACGCCGGCGACCATCGCCGAGCGTAACCAGCAGATCGCCGCTATCGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella", "NCBI_taxonomy_id": "570", "NCBI_taxonomy_cvterm_id": "37059"}, "protein_sequence": {"GI": "WP_025712239", "sequence": "MRYVRLCVISLLANLPLAVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGVEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTIGELCAAAITMSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDMRDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGARGIVALLGPDGKAERIVVIYMRDTPATIAERNQQIAAIGAALIEHWQR"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "LEN-26", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "38874", "model_name": "LEN-26", "model_type_id": "40292"}, "2327": {"model_id": "2327", "ARO_accession": "3003840", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin, an aminocoumarin antibiotic, in Escherichia coli.", "model_sequences": {"sequence": {"3604": {"dna_sequence": {"fmax": "1334829", "fmin": "1333854", "accession": "NC_000913.3", "strand": "+", "sequence": "ATGAAATTACAACAACTTCGCTATATTGTTGAGGTGGTCAATCATAACCTGAATGTCTCATCAACAGCGGAAGGACTTTACACATCACAACCCGGGATCAGTAAACAAGTCAGAATGCTGGAAGACGAGCTAGGCATTCAAATTTTTTCCCGAAGCGGCAAGCACCTGACGCAGGTAACGCCAGCAGGGCAAGAAATAATTCGTATCGCTCGCGAAGTCCTGTCGAAAGTCGATGCCATAAAATCGGTTGCCGGAGAGCACACCTGGCCGGATAAAGGTTCACTGTATATCGCCACCACGCATACCCAGGCACGCTACGCATTACCAAACGTCATCAAAGGCTTTATTGAGCGTTATCCTCGCGTTTCTTTGCATATGCACCAGGGCTCGCCGACACAAATTGCTGATGCCGTCTCTAAAGGCAATGCTGATTTCGCTATCGCCACAGAAGCGCTGCATCTGTATGAAGATTTAGTGATGTTACCGTGCTACCACTGGAATCGGGCTATTGTAGTCACTCCGGATCACCCGCTGGCAGGCAAAAAAGCCATTACCATTGAAGAACTGGCGCAATATCCGTTGGTGACATATACCTTCGGCTTTACCGGACGTTCAGAACTGGATACTGCCTTTAATCGCGCAGGGTTAACGCCGCGTATCGTTTTCACGGCAACGGATGCTGACGTCATTAAAACTTACGTCCGGTTAGGGCTGGGGGTAGGGGTCATTGCCAGCATGGCGGTGGATCCGGTCGCCGATCCCGACCTTGTGCGTGTTGATGCTCACGATATCTTCAGCCACAGTACAACCAAAATTGGTTTTCGCCGTAGTACTTTCTTGCGCAGTTATATGTATGATTTCATTCAGCGTTTTGCACCGCATTTAACGCGTGATGTCGTTGATGCGGCTGTCGCATTGCGCTCTAATGAAGAAATTGAGGTCATGTTTAAAGATATAAAACTGCCGGAAAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_415791.1", "sequence": "MKLQQLRYIVEVVNHNLNVSSTAEGLYTSQPGISKQVRMLEDELGIQIFSRSGKHLTQVTPAGQEIIRIAREVLSKVDAIKSVAGEHTWPDKGSLYIATTHTQARYALPNVIKGFIERYPRVSLHMHQGSPTQIADAVSKGNADFAIATEALHLYEDLVMLPCYHWNRAIVVTPDHPLAGKKAITIEELAQYPLVTYTFGFTGRSELDTAFNRAGLTPRIVFTATDADVIKTYVRLGLGVGVIASMAVDPVADPDLVRVDAHDIFSHSTTKIGFRRSTFLRSYMYDFIQRFAPHLTRDVVDAAVALRSNEEIEVMFKDIKLPEK"}}}}, "ARO_category": {"36616": {"category_aro_name": "aminocoumarin resistance gene", "category_aro_cvterm_id": "36616", "category_aro_accession": "3000477", "category_aro_description": "Point mutations to DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. In some cases, expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can also confer aminocoumarin resistance. Aminocoumarin efflux pump exists that export the drug out of the cell to confer resistance"}}, "ARO_name": "aminocoumarin resistant cysB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40533", "model_name": "aminocoumarin resistant cysB", "model_type_id": "40292"}, "2335": {"model_id": "2335", "ARO_accession": "3003848", "model_param": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "ADC-2 is a beta-lactamase found in Oligella urethralis.", "model_sequences": {"sequence": {"3628": {"dna_sequence": {"fmax": "1252", "fmin": "100", "accession": "NG_048644.1", "strand": "+", "sequence": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCTCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTAATGCCAACCTTAACCCACAAAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Proteobacteria", "NCBI_taxonomy_id": "1224", "NCBI_taxonomy_cvterm_id": "40546"}, "protein_sequence": {"GI": "WP_004746565.1", "sequence": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "ADC-2", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40545", "model_name": "ADC-2", "model_type_id": "40292"}, "2318": {"model_id": "2318", "ARO_accession": "3003828", "model_param": {"blastp_evalue": {"param_value": "1e-60", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "adiY is a DNA-binding transcriptional activator of the adi system. Implicated in arginine-dependent acid resistance in Escherichia coli.", "model_sequences": {"sequence": {"3591": {"dna_sequence": {"fmax": "4337929", "fmin": "4337167", "accession": "NC_000913.3", "strand": "-", "sequence": "TCAGGCGACAGTGCGTTCTCTGTGCTGACTAACATAATGCAGCGGCGTCATACCGTAGAAGTCTTTAAAGACAGAAATAAAGTACGACGTACTGTTGTAGCCGCAGGACTGTGATACCTGAGAGATATTTTTACCGTCCATCATTAATTCATTTACGGCATAACGCATGCGGCAGGTGGTGATTATTTGGCTATAACTGGTGTTTTCGCTTTTCAACTTTTTCTTTAACAGACTTGGGCTAAGACATAAACAACTGGCTACCATACTAAGATTCCAGTCTTTGTGAATATCGCTTTCAATAATTTGATAAACGCTGTCACTTACACAATTACGTAACATATACATCATTAATGAAACGAATTTTTTACTGTCGAGAAAACGGGATAGCACCGTGAATAATAATGCGCGTGTTCGTTCCTTTTCTGACTCAGTTTCTGCGGGCATCATGCTGTGTTGCGCGGCAACGCGAAAGACGTCTGGCGTCAGGCATGGCAGGGTGAGTATGGGCGTAGCGCTACGTTGCCATACTGGTATTTGCGAGAGATCTTTATTCAGAAACCGGAGGTAATCTTTGATGATGTCGTGACTAATATGAGCAACCAAAGTGTTGTTAAGAGAGGAGACGTCGATAATATTATTTTCACAATTTAATAACGCCATATGGTTAGCTTTAAGGCTAATAGGTTCTTTCCCATTCACCCTTATCCAGACATCTTTTTCAGTCAATAAAACAATACAAGGTTGGTCGCTGCAAATCCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_418540.1", "sequence": "MRICSDQPCIVLLTEKDVWIRVNGKEPISLKANHMALLNCENNIIDVSSLNNTLVAHISHDIIKDYLRFLNKDLSQIPVWQRSATPILTLPCLTPDVFRVAAQHSMMPAETESEKERTRALLFTVLSRFLDSKKFVSLMMYMLRNCVSDSVYQIIESDIHKDWNLSMVASCLCLSPSLLKKKLKSENTSYSQIITTCRMRYAVNELMMDGKNISQVSQSCGYNSTSYFISVFKDFYGMTPLHYVSQHRERTVA"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "adiY", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40519", "model_name": "adiY", "model_type_id": "40292"}, "2319": {"model_id": "2319", "ARO_accession": "3003830", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli", "model_sequences": {"sequence": {"3592": {"dna_sequence": {"fmax": "2822011", "fmin": "2819380", "accession": "NC_000913.3", "strand": "-", "sequence": "TTATTGCAATTTCGCGCTGACCCAGCCTTTCACACTGGCTAACGCTGCAGGTAAGGCCGCAGCATCCGTACCACCGGCTTGCGCCATGTCAGGACGTCCACCACCCTTGCCGCCCACCTGCTGAGCGACCATACCAATCAGTTCCCCTGCTTTCACACGATCTGTGACGTCCTTAGATACGCCTGCAATCAGAGAAACCTTACCTTCGACTACCGTTGCCAGCACGATAATTGTCGACCCCAGCTGATTTTTTAAATCGTCAACCATGGTACGCAACATTTTCGGCTCAACACCGCTAAGCTCGCTAACCAACAGCTTAACACCATTAACATCAATTGCCTTACTGGAAAGATTTGCGCTCTCCTGTGCGGCAGCTTGTTCTTTAAGCTGTTGTAACTCTTTTTCCAGCTGACGCGTACGTTCCAGTACTGAGCGCACTTTATCAGCCAGATTATTGCTATCGCCTTTCAGCAGATGCGCGACTTCGCTTAAGCGATCGCTGTCTGCATGAACGGTGGCGATAGCACCTTCTCCGGTTACCGCTTCGATACGACGAACGCCTGCAGCAGTACCCGATTCAGAGATGATGCGGAACAGACCAATATCACCAGTGCGGCTGGCGTGAGTACCGCCACACAACTCGGTAGAGAAATCGCCCATGCTCAGCACGCGTACGCGCTCATCATACTTCTCGCCGAACAGCGCCATCGCACCTTTCGCTTTCGCCGCTTCGAGATCCATGATGTTGGTTTCGATCGGCAAATTGCGACGAATCTGTGTGTTCACCAGGTCTTCGACCGCACGAATCTCTTCTGGTTTCATCGCTTCGTTGTGTGAGAAGTCGAAGCGCAGCACCTTGTCGTTAACCAGTGAACCTTTCTGCGATACATGAGTACCCAGAACCTGGCGCAGCGCAGCGTGCATCAGGTGCGTTGCGGAGTGATTCAGACGAATACGGGCGCGACGAGCCTCATCAACATCAGCCTGCACCGCGTCGCCCACTTTCAGAGAACCCGCAGCAAGTTTACCGATGTGACCAATCGCCTGGCCGTATTTCTGCGTATCTTCCACCGCAAAGGAGAAGTTAGCGCCTTTCAGTTCGCCTTTATCGCCAACCTGACCGCCGGATTCCGCATAGAATGGCGTTTGATCCAGCACGACCACAGCTTCCTGGCCTGCATTGATGGCATCAACCGCTTTACCATCAACAAACAGCGCAGTCACTTTGCCGTTCAGTTCCAGATGGTCATAGCCTTTAAATTCAGATGCACTGTCAACACGGATCATTGCGTTGTAATCGGCACCAAAGCCGCTGGCTTCGCGCGCGCGACGACGCTGCTCTTCCATTGCAGCTTCAAAACCAGCTTCGTCAACTTTGATGTTGCGCTCACGACAAACATCAGCCGTCAGGTCAACCGGGAAGCCATAGGTGTCGTACAGACGGAAAGCAGTTTCACCATCCAGCGTATCACCAGAAAGTTTTGCCAGCTCTTCATCCAGCAACGCCAGACCGCGCTCCAGAGTACGAGCAAACTGCTCTTCTTCAGTCTTCAGCACCTGCTCAACCTGCGCCTGCTGGCGTTTCAGGTCTTCACCCGCAGAGCCCATAACGTCGATCAGCGGACCAACCAGTTTGTAGAAGAAGGTTTCTTTCGCGCCGAGCATATTACCGTGACGCACTGCGCGACGAATGATACGACGCAGTACATAACCACGGTTTTCATTGGACGGCATTACGCCATCCGCGATCAGGAACGCACAAGAACGAATGTGGTCAGCGATTACGCGCAGCGATTTATTGCTCAGATCGGTTGCGCCAGTGACTTTCGCTACCGCCTGGATCAGCGTGCGGAACAGGTCGATGTCATAGTTAGAGTTAACGTGTTGCAGCACCGCAGCAATACGCTCCAGACCCATACCGGTATCTACAGACGGCTTCGGCAGCGGTTCCATCGTGCCATCGGCCTGGCGGTTGAACTGCATGAAGACGATGTTCCAGATCTCAATGTAGCGGTCGCCGTCTTCTTCCGGGCTTCCCGGAGGGCCCCCCCAAATGTGGTCGCCGTGATCGTAGAAGATTTCGGTGCACGGGCCGCACGGACCAGTGTCACCCATCTGCCAGAAGTTGTCAGATGCGTATGGCGCACCTTTGTTATCGCCGATGCGAATAATACGTTCGCGCGGGATCCCTACTTCTTTTTCCCAGATTTCGTAGGCTTCGTCGTCGCTTTCATAGACGGTAACCCACAGACGCTCTTTCGGCAGGGCAAACCATTTTTCGCTGGTCAGCAGTTCCCATGCAAACTGAATGGCATCGTGTTTGAAATAGTCGCCGAAGCTGAAGTTGCCCAGCATTTCGAAGAAGGTATGGTGACGCGCGGTGTAACCGACGTTTTCCAGGTCGTTGTGTTTACCACCCGCACGCACGCAGCGTTGGGAAGTGGTAGCGCGGGAATAATTACGCTTGTCGAGCCCAAGGAACACATCCTTGAACTGGTTCATCCCGGCGTTGGTAAACAACAAAGTTGGGTCGTTATGGGGTACCAGGGAGCTGCTGGCAACTACCTGATGTCCCTTACTATGGAAAAAGTCGAGAAACGCCTGACGGATCTCAGCGGTGCTCTTGCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_417177.1", "sequence": "MSKSTAEIRQAFLDFFHSKGHQVVASSSLVPHNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKHDAIQFAWELLTSEKWFALPKERLWVTVYESDDEAYEIWEKEVGIPRERIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERIAAVLQHVNSNYDIDLFRTLIQAVAKVTGATDLSNKSLRVIADHIRSCAFLIADGVMPSNENRGYVLRRIIRRAVRHGNMLGAKETFFYKLVGPLIDVMGSAGEDLKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLSGDTLDGETAFRLYDTYGFPVDLTADVCRERNIKVDEAGFEAAMEEQRRRAREASGFGADYNAMIRVDSASEFKGYDHLELNGKVTALFVDGKAVDAINAGQEAVVVLDQTPFYAESGGQVGDKGELKGANFSFAVEDTQKYGQAIGHIGKLAAGSLKVGDAVQADVDEARRARIRLNHSATHLMHAALRQVLGTHVSQKGSLVNDKVLRFDFSHNEAMKPEEIRAVEDLVNTQIRRNLPIETNIMDLEAAKAKGAMALFGEKYDERVRVLSMGDFSTELCGGTHASRTGDIGLFRIISESGTAAGVRRIEAVTGEGAIATVHADSDRLSEVAHLLKGDSNNLADKVRSVLERTRQLEKELQQLKEQAAAQESANLSSKAIDVNGVKLLVSELSGVEPKMLRTMVDDLKNQLGSTIIVLATVVEGKVSLIAGVSKDVTDRVKAGELIGMVAQQVGGKGGGRPDMAQAGGTDAAALPAALASVKGWVSAKLQ"}}}}, "ARO_category": {"36616": {"category_aro_name": "aminocoumarin resistance gene", "category_aro_cvterm_id": "36616", "category_aro_accession": "3000477", "category_aro_description": "Point mutations to DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. In some cases, expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can also confer aminocoumarin resistance. Aminocoumarin efflux pump exists that export the drug out of the cell to confer resistance"}}, "ARO_name": "aminocoumarin resistant alaS", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40521", "model_name": "aminocoumarin resistant alaS", "model_type_id": "40292"}, "2317": {"model_id": "2317", "ARO_accession": "3003820", "model_param": {"blastp_evalue": {"param_value": "1e-30", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "mgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae", "model_sequences": {"sequence": {"3586": {"dna_sequence": {"fmax": "1908766", "fmin": "1908622", "accession": "NC_000913.3", "strand": "-", "sequence": "TCACCACGGGATAAACTGGTTAATGGCACAAATTCCGCTGAAAAATTGTACATCCTGATCGCACATCATGTTGAATACCTGCGCCCAAAGCAGCAAGCAAGCCAACACCACGACAACCAGAACGACCCATCGAAACTTTTTCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_416340.1", "sequence": "MKKFRWVVLVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINQFIPW"}}}}, "ARO_category": {"36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}, "40190": {"category_aro_name": "gene altering cell wall charge conferring antibiotic resistance", "category_aro_cvterm_id": "40190", "category_aro_accession": "3003580", "category_aro_description": "Genes involved in alteration of the cell wall overall charge, leading to antimicrobial resistance due to reduced binding"}, "36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}, "36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "40439": {"category_aro_name": "gene conferring resistance via absence", "category_aro_cvterm_id": "40439", "category_aro_accession": "3003768", "category_aro_description": "Deletion of gene or gene product results in resistance. For example, deletion of a porin gene blocks drug from entering the cell."}, "39418": {"category_aro_name": "polymyxin resistance gene", "category_aro_cvterm_id": "39418", "category_aro_accession": "3002984", "category_aro_description": "Genes conferring resistance to polymyxins"}}, "ARO_name": "mgrB", "model_type": "absent protein homolog model", "model_description": "A model to detect the absence of a protein that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences and a curated BLASTP cut-off.", "ARO_id": "40510", "model_name": "mgrB", "model_type_id": "40354"}, "2329": {"model_id": "2329", "ARO_accession": "3002191", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "MOX-9 is a beta-lactamase found in Citrobacter freundii.", "model_sequences": {"sequence": {"3606": {"dna_sequence": {"fmax": "1252", "fmin": "100", "accession": "NG_049322", "strand": "+", "sequence": "ATGCAACAACAGGTGCGGATGACATTGCTGATGGCGAGCACGCTGCTCTGGGCCGGTCTGGCCCAGGCCACGGCGGACACCCAGGCCGATCCCCTGCGCCCCCTGGTGGATGCCAGTATCCGGCCCGTGCTCAAGGAGCACCGGATCCCCGGCATGGCGGTGGCGGTGCTGAAAGATGGCAAGGCCCACTACTTCAACTACGGGGTGGCCAACCGGGAGAGCGGGGCCCGTGTCAGCGAGCAGACCCTGTTCGAGATTGGATCGGTCAGCAAGACTCTTACGGCAACGCTTGGGGCTTATGCCGTGGTGAAGGGGGCGCTCAAGCTCGATGACAAGGTGAGTCAGCATGGGCCCTGGCTGAAAGGATCGGCTTTTGACGGTATCACCATGGCCGAGCTCGCCACCTACAGCGCCGGGGGCTTGCCGCTGCAATTCCCCGACGAGGTGGATTCCATCGACAAGATGCGTGCCTACTATCGCCAGTGGACGCCTGCCTATCGGGCGGGCAGCCATCGCCAGTACTCCAACCCCAGCATCGGCCTGTTCGGCCATCTCGCGGCCCAGAGCCTGGGCCAACCCTTTGAACAGTTGATGAGCCAGACCCTGCTGCCCGGGCTTGGTCTCGAGCACACCTATCTCAAGGTCCCTGCCGAGGCCATGGCGAACTACGCCTATGGCTACTCGAAAGAGGACAAGCCTATCAGGGTCAACCCGGGGGTCCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGAAGTTTGTCGGCGCCAACATGACAGGCACCGGGGACGAGGCGATGCAGCAGGCGATTGCCCTGACCCACAAGGGGGTTTACTCGGTGGGTGCCATGACTCAGGGGCTCGGCTGGGAGAGTTATGCCTATCCCGTGACCGAAGAGACCTTGCTTGCAGGCAACTCGGGCAAGGTGATCCTCGAGGCCAACCCGACGGCGCCCGCCTCCAACGAGACGGGTAGCCAGGTGCTCTTCAACAAGACCGGCTCCACCGGCGGCTTTGGTGCCTATGTGGCCTTTGTGCCAGCCAAGGGGATTGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCAGGCCAGGGTAGAGACGGCCCACGCCATCCTGAGCAAGCTGGCCGAGTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Gammaproteobacteria", "NCBI_taxonomy_id": "1236", "NCBI_taxonomy_cvterm_id": "40536"}, "protein_sequence": {"GI": "WP_042649345", "sequence": "MQQQVRMTLLMASTLLWAGLAQATADTQADPLRPLVDASIRPVLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGARVSEQTLFEIGSVSKTLTATLGAYAVVKGALKLDDKVSQHGPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSIDKMRAYYRQWTPAYRAGSHRQYSNPSIGLFGHLAAQSLGQPFEQLMSQTLLPGLGLEHTYLKVPAEAMANYAYGYSKEDKPIRVNPGVLADEAYGIKTSSADLLKFVGANMTGTGDEAMQQAIALTHKGVYSVGAMTQGLGWESYAYPVTEETLLAGNSGKVILEANPTAPASNETGSQVLFNKTGSTGGFGAYVAFVPAKGIGIVMLANRNYPIQARVETAHAILSKLAE"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "MOX-9", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "38591", "model_name": "MOX-9", "model_type_id": "40292"}, "2325": {"model_id": "2325", "ARO_accession": "3003839", "model_param": {"blastp_evalue": {"param_value": "1e-60", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Part of the macrolide inactivation gene cluster in Aeromonas hydrophila", "model_sequences": {"sequence": {"3600": {"dna_sequence": {"fmax": "8983", "fmin": "7744", "accession": "AY522923.1", "strand": "-", "sequence": "TCAGTGTTCACCTTCTGTATGGGTTGGGGCGGAGGCTGTGGCTGCCGCCGCCATTGTAGCAAATTGAAGACGGAGCGAGAGTAGAGCCACGAGCCCCGCAAACACGGCCGATACAACGAGGCCAGGGAGCGGACCAGCAAGGTCGACAAACGCGCCGGCCGCAAGCATAACCATGGGCGAGGCTGACAGCATCACCGCCGAGACCGTGCCGAGTACCCGGCCGAGAAGTTCTGGCGGCGTGCGGTTGTAGATGGCAGCGTTGAGAATGGGAGAGACTGAGCCGGTCAGCAGTCCCACGAGCGCGCCCAACAACATCAGCACCGGCACGCCTGGCAACTGTGAAAGCAGAAGCGAGCCCACCGCAGAGCCACAAAATGCCACCGCCAGCCAGTTCTGCGCTGATATCCGGGCGCCGACCGACGCATGAATGGCAATGCCAAGGAGACCACCAGCCCCCATCATTGAGGAGAACAGCCCGAGCTCTGCTACTTGGCGTCCTGCATCTACAAACAGCGCAGGCATGATGACGCTGCCGTTGGCGCCAACGATGCCCACGAAGATCATCACTATACCAAAGAGAGGGCGCAGCAGGGGTTCGCTCCAGAGAAAAGCGACGCCGGCGCGCATGGAGAGAGTCGCCGTCGTGGTCATCGTCCGAGCGGCACGCGCGGGAAGCACCCACGCGCCGAGCAGACCTGCAAGGACGGAGCAGAACGCCGTCAGCCCGAGCGTTGGCGCAGCGCCAAGCAGGCCGATTGCGGCCCCCCCAAGGGCCGGGCCACCTAGAATCGCGACGTTCCCGATCACCGCTTTCAGTGACGAGACGCGCTCAACGGAGAGCCCGGCGACGTGGCCGAGTTTGGGCAGCTCACTGTCCTGCGCGGCCATACCGGGTGCGTCGAACGCGGCACCGAGCACCACGCAAGCGATCAGCCCAGTGTTCGAGAGGGCGCCAACGGCATCGAGCAGTGGGATGCTCGCCATGGCCACGCCGCCCACCACACCCGAGATCAATGCGACGGGCGCGCGCCCGAACCGATCGACGAGGCCACCACCAACCCACGCGCCGATGATGGTCGCGATGACGCTGCTAGCGGCCGTGGCGCCCGCCCAGGCCGCGCTCTTTGTATGAGACAGGACGAACCATGGAAGCGCGAGGGCCGCCACCGCGTTGCCGATCCGGAAGAGAAAGGTCGCCGCGAACAGCGTCGCGAGCGGGCTATATCGACGTTCGCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Aeromonas hydrophila", "NCBI_taxonomy_id": "644", "NCBI_taxonomy_cvterm_id": "36810"}, "protein_sequence": {"GI": "AAS13767.1", "sequence": "MSERRYSPLATLFAATFLFRIGNAVAALALPWFVLSHTKSAAWAGATAASSVIATIIGAWVGGGLVDRFGRAPVALISGVVGGVAMASIPLLDAVGALSNTGLIACVVLGAAFDAPGMAAQDSELPKLGHVAGLSVERVSSLKAVIGNVAILGGPALGGAAIGLLGAAPTLGLTAFCSVLAGLLGAWVLPARAARTMTTTATLSMRAGVAFLWSEPLLRPLFGIVMIFVGIVGANGSVIMPALFVDAGRQVAELGLFSSMMGAGGLLGIAIHASVGARISAQNWLAVAFCGSAVGSLLLSQLPGVPVLMLLGALVGLLTGSVSPILNAAIYNRTPPELLGRVLGTVSAVMLSASPMVMLAAGAFVDLAGPLPGLVVSAVFAGLVALLSLRLQFATMAAAATASAPTHTEGEH"}}}}, "ARO_category": {"36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}, "ARO_name": "Mrx", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40531", "model_name": "Mrx", "model_type_id": "40292"}, "2321": {"model_id": "2321", "ARO_accession": "3003835", "model_param": {"blastp_evalue": {"param_value": "1e-60", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Clostridium difficile and Escherichia coli multidrug efflux transporter with antiporter function. Confers resistance to fluoroquinolones in E. coli and acriflavin in C.difficile.", "model_sequences": {"sequence": {"3596": {"dna_sequence": {"fmax": "1696", "fmin": "370", "accession": "AJ574887.1", "strand": "-", "sequence": "TTAATACTTATATCTACCTTTATATTTTTTTATAAATAGAATAGATATAAATATGGTTATAACCTCAGCAAATGGAACTGTAAGCCATAATCCAGTCATGTTTAACATAGGAGGAAGAATTATGATTCCTATGATTATAAAAACAAAGGCACGACTAAAAGATATAATAGCTGAAATTTTTCCATTGTGAAATGCTGTAAAAAATCCTGATGCAAATATATTTATACCAACAAACAAAAAAGCAAATGCAAATATTTTTAATCCTTGTAAGGCTAGTTTAAATACTGTGTTATCTGGATTTACAAAGACCCTAACAATAAATGGTGCAAATACTAAAGCAATAATAAACACTAAAAGAGAAGAAATAAATATAAATTTTAGAGAATGTTTAAATGTTTCTTTTAATTTATCACTGTTTTCAGCACCAAAATTATAGCTTATTAATGGAGACACTCCAGCAGCGAATCCTAGATAGACTGATGTCATTAAAAAATGAGCATACAATACTATAGTAAGAGCAGCAAGTCCATTTTCTCCTGCTAATTTTAAAGCTACTACATTAAATAAGAATGTTGTAATTCCTGTAGATAATTCTGTAACCATTTCAGAAGAACCGTTTATCATAGTATCTCTTATAAGTCTAAAATCGGTTTTTGGTTTTCTTAATTTTAGTGTAGATTTATTAGATAAGAAGTAAATAATACCTAAAACACAAGTTAAAATAATACCTATAGCAGTTGCAACTGCAGCTCCTAAAAGACCCATTCCAAAATATTTAATAAATACATAATCCAATATTATATTTGTTACACCACCAATGACTGATAGAAATAAACTAAATTTAGAATTTCCATCAGTTCTTGCAAAGTACTCAAATATAAATTTTAAAATATAAAATGGTGTACATAAAATCATAACTTTACCATAAGTTATACAATATGGTAATAACTTATCTGTTGCACCAAGCAAAATAGATATTTCTTTGATAAAGAAATATGAGATTACTGTGAATAAAATCCCAACAATCAATGAAAACAAAACTATAAAAGAAAATGTAGAGTTGGCTTCATCCTGTCTATTTTCACCCATACGTATAGAAACGATAGCACCTCCACCAGTTGCCATCATTATTCCAAATCCACAAACAAGGTTAATTATAGGTAGTACAATATTTATACTAGCAAGAGCATCAGAACCAACTAATGTCGATACAAAGATGCCATCTATTATTGTGTACAAAGATATAAATATCATGGATATAATTGCAGGAGAAACAAATTTTAGAAATTCAAAAGTAGTGAATTTTCTTGTAAATAAATTTTCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Clostridium difficile", "NCBI_taxonomy_id": "1496", "NCBI_taxonomy_cvterm_id": "36807"}, "protein_sequence": {"GI": "CAE00499.1", "sequence": "MENLFTRKFTTFEFLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFLFNVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFISSLLVFIIALVFAPFIVRVFVNPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLNMTGLWLTVPFAEVITIFISILFIKKYKGRYKY"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "CdeA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40526", "model_name": "CdeA", "model_type_id": "40292"}, "2310": {"model_id": "2310", "ARO_accession": "3003359", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Sequence variants of Streptomyces cinnamoneus elongation factor Tu that confer resistance to elfamycin antibiotics.", "model_sequences": {"sequence": {"3578": {"dna_sequence": {"fmax": "1555", "fmin": "361", "accession": "X98831.1", "strand": "+", "sequence": "GTGGCGAAGGCGAAGTTCGAGCGGACTAAGCCGCACGTCAACATCGGCACCATCGGTCACGTCGACCACGGTAAGACGACTCTTACCGCGGCGATCACCAAGGTGCTGCACGACGCGATCCCGGACCTGAACCCCTTCACGCCGTTCGACGAGATCGACAAGGCGCCGGAAGAGCGTCAGCGCGGTATCACGATCTCGATCGCTCACGTTGAGTACCAGACCGAGTCGCGTCACTACGCCCACGTCGACTGCCCGGGTCACGCAGACTACATCAAGAACATGATCACCGGTGCCGCCCAGATGGACGGCGCGATCCTCGTGGTCGCCGCGACCGACGGTCCGATGCCGCAGACCAAGGAGCACGTGCTCCTGGCCCGCCAGTCCGGCGTTCCGTACATTGTGGTGGCCCTGAACAAGGCCGACATGGTGGACGACGAGGAGATCATGGAGCTCGTCGAGCTCGAGGTCCGTGAGCTCCTCTCCGAGTACGAGTTCGACGGCGACAACTGCCCCGTCGTCCAGGTCTCGGCTCTCAAGGCGCTCGAGGGCGACAAGGAGTGGGGCGAGAAGCTCCTCGGCCTCATGAAGGCCGTGGACGAGAACATCCCGCAGCCCGAGCGTGACGTCGACAAGCCGTTCCTGATGCCGATCGAGGACGTCTTCACGATCACCGGTCGTGGCACCGTCGTCACCGGTCGTATCGAGCGCGGTGTCCTCAAGGTCAACGAGACCGTCGACATCATCGGCATCAAGACCGAGAAGACCACCACCACGGTCACCGGTATCGAGATGTTCCGCAAGCTGCTCGACGAGGGCCAGGCCGGTGAGAACGTCGGTCTGCTCCTCCGTGGCATCAAGCGCGAGGACGTCGAGCGCGGCCAGTGCATCATCAAGCCCGGTACGGTCACGCCGCACACCGAGTTCGAGGCCACGGCGTACATCCTGTCGAAGGACGAGGGTGGCCGTCACACCCCGTTCTTCAACAACTACCGTCCGCAGTTCTACTTCCGTACGACTGACGTGACCGGTGTTGTGACCCTCAAGGAGGGCACGGAGATGGTCATGCCCGGCGACAACGCCGAGATGACCGTCAACCTGATCCAGCCTGTCGCGATGGAGGAGGGCCTGCGCTTCACCATCCGTGAGGGTGGCCGCACCGTCGGCGCCGGCCAGGTCGTCAAGATCAACAAGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces cinnamoneus", "NCBI_taxonomy_id": "53446", "NCBI_taxonomy_cvterm_id": "40498"}, "protein_sequence": {"GI": "CAA67349.1", "sequence": "MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDAIPDLNPFTPFDEIDKAPEERQRGITISIAHVEYQTESRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTKEHVLLARQSGVPYIVVALNKADMVDDEEIMELVELEVRELLSEYEFDGDNCPVVQVSALKALEGDKEWGEKLLGLMKAVDENIPQPERDVDKPFLMPIEDVFTITGRGTVVTGRIERGVLKVNETVDIIGIKTEKTTTTVTGIEMFRKLLDEGQAGENVGLLLRGIKREDVERGQCIIKPGTVTPHTEFEATAYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLKEGTEMVMPGDNAEMTVNLIQPVAMEEGLRFTIREGGRTVGAGQVVKINK"}}}}, "ARO_category": {"36631": {"category_aro_name": "gene involved in self resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "37710": {"category_aro_name": "elfamycin resistance gene", "category_aro_cvterm_id": "37710", "category_aro_accession": "3001311", "category_aro_description": "Genes conferring resistance to elfamycin antibiotics."}}, "ARO_name": "Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39943", "model_name": "Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin", "model_type_id": "40292"}, "2306": {"model_id": "2306", "ARO_accession": "3003807", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"3903": "R45C"}, "clinical": {"3903": "R45C"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli.", "model_sequences": {"sequence": {"3575": {"dna_sequence": {"fmax": "486408", "fmin": "485760", "accession": "NC_000913.3", "strand": "+", "sequence": "ATGGCACGAAAAACCAAACAAGAAGCGCAAGAAACGCGCCAACACATCCTCGATGTGGCTCTACGTCTTTTCTCACAGCAGGGGGTATCATCCACCTCGCTGGGCGAGATTGCAAAAGCAGCTGGCGTTACGCGCGGTGCAATCTACTGGCATTTTAAAGACAAGTCGGATTTGTTCAGTGAGATCTGGGAACTGTCAGAATCCAATATTGGTGAACTAGAGCTTGAGTATCAGGCAAAATTCCCTGGCGATCCACTCTCAGTATTAAGAGAGATATTAATTCATGTTCTTGAATCCACGGTGACAGAAGAACGGCGTCGATTATTGATGGAGATTATATTCCACAAATGCGAATTTGTCGGAGAAATGGCTGTTGTGCAACAGGCACAACGTAATCTCTGTCTGGAAAGTTATGACCGTATAGAACAAACGTTAAAACATTGTATTGAAGCGAAAATGTTGCCTGCGGATTTAATGACGCGTCGCGCAGCAATTATTATGCGCGGCTATATTTCCGGCCTGATGGAAAACTGGCTCTTTGCCCCGCAATCTTTTGATCTTAAAAAAGAAGCCCGCGATTACGTTGCCATCTTACTGGAGATGTATCTCCTGTGCCCCACGCTTCGTAATCCTGCCACTAACGAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_414997.1", "sequence": "MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE"}}}}, "ARO_category": {"36537": {"category_aro_name": "chloramphenicol resistance gene", "category_aro_cvterm_id": "36537", "category_aro_accession": "3000398", "category_aro_description": "Genes conferring resistance to chloramphenicol."}, "36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}, "36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36611": {"category_aro_name": "tetracycline resistance gene", "category_aro_cvterm_id": "36611", "category_aro_accession": "3000472", "category_aro_description": "Genes conferring resistance to tetracycline antibiotics."}, "36522": {"category_aro_name": "rifampin resistance gene", "category_aro_cvterm_id": "36522", "category_aro_accession": "3000383", "category_aro_description": "Genetic determinants which confer resistance to rifampin."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "Escherichia coli acrR mutants resulting in antibiotic resistance", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40492", "model_name": "Escherichia coli acrR mutants resulting in antibiotic resistance", "model_type_id": "40293"}, "2320": {"model_id": "2320", "ARO_accession": "3003833", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "fyuA is a pesticin receptor that is found in E.coli. The fyuA gene encodes the outer membrane receptor for the siderophore yersiniabactin (Ybt) and the hemR gene.", "model_sequences": {"sequence": {"3595": {"dna_sequence": {"fmax": "2183", "fmin": "161", "accession": "Z38064.1", "strand": "+", "sequence": "ATGAAAATGACACGGCTTTATCCTCTGGCCTTGGGGGGATTATTGCTCCCCGCCATTGCTAATGCCCAGACTTCACAGCAAGACGAAAGCACGCTGGTGGTTACCGCCAGTAAACAATCTTCCCGCTCGGCATCAGCCAACAACGTCTCGTCTACTGTTGTCAGCGCGCCGGAATTAAGCGACGCCGGCGTCACCGCCAGCGACAAACTCCCCAGAGTCTTGCCCGGGCTCAATATTGAAAATAGCGGCAACATGCTTTTTTCGACGATCTCGCTACGCGGCGTCTCTTCAGCGCAGGACTTCTATAACCCCGCCGTCACCCTGTATGTCGATGGCGTCCCTCAGCTTTCCACCAACACCATCCAGGCGCTTACCGATGTGCAAAGCGTGGAGTTGCTGCGAGGCCCACAGGGAACGTTATATGGCAAAAGCGCTCAGGGCGGGATCATCAACATCGTCACCCAGCAGCCGGACAGCACGCCGCGCGGCTATATTGAAGGCGGCGTCAGTAGCCGCGACAGTTATCGAAGTAAGTTCAACCTGAGCGGCCCCATTCAGGATGGCCTGCTGTACGGCAGCGTCACCCTGTTACGCCAGGTTGATGACGGCGACATGATTAACCCCGCGACGGGAAGCGATGACTTAGGCGGCACCCGCGCCAGCATAGGGAATGTGAAACTGCGTCTGGCGCCGGACGATCAGCCCTGGGAAATGGGCTTTGCCGCCTCACGCGAATGTACCCGCGCCACCCAGGACGCCTATGTGGGATGGAATGATATTAAGGGCCGTAAGCTGTCGATCAGCGATGGTTCACCAGACCCGTACATGCGGCGCTGCACTGACAGCCAGACCCTGAGTGGGAAATACACCACCGATGACTGGGTTTTCAACCTGATCAGCGCCTGGCAGCAGCAGCATTATTCGCGCACCTTCCCTTCCGGTTCGTTAATCGTCAATATGCCTCAGCGCTGGAATCAGGATGTGCAGGAGCTGCGCGCTGCAACCCTGGGCGATGCGCGTACCGTTGATATGGTGTTTGGGCTGTACCGGCAGAACACCCGCGAGAAGTTAAATTCAGCCTACGACATGCCGACAATGCCTTATTTAAGCAGTACCGGCTATACCACCGCTGAAACGCTGGCCGCATACAGTGACCTGACCTGGCATTTAACCGATCGTTTTGATATCGGCGGCGGCGTGCGCTTCTCGCATGATAAATCCAGTACACAATATCACGGCAGCATGCTCGGCAACCCGTTTGGCGACCAGGGTAAGAGCAATGACGATCAGGTGCTCGGGCAGCTATCCGCAGGCTATATGCTGACCGATGACTGGAGAGTGTATACCCGTGTAGCCCAGGGATATAAACCTTCCGGGTACAACATCGTGCCTACTGCGGGTCTTGATGCCAAACCGTTCGTCGCCGAGAAATCCATCAACTATGAACTTGGCACCCGCTACGAAACCGCTGACGTCACGCTGCAAGCCGCGACGTTTTATACCCACACCAAAGACATGCAGCTTTACTCTGGCCCGGTCGGGATGCAGACATTAAGCAATGCGGGTAAAGCCGACGCCACCGGCGTTGAGCTTGAAGCGAAGTGGCGGTTTGCGCCAGGCTGGTCATGGGATATCAATGGCAACGTGATCCGTTCCGAATTCACCAATGACAGTGAGTTGTATCACGGTAACCGGGTGCCGTTCGTACCACGTTATGGCGCGGGAAGCAGCGTGAACGGCGTGATTGATACGCGCTATGGCGCACTGATGCCCCGACTGGCGCTTAATCTGGTCGGGCCGCATTATTTCGATGGCGACAACCAGTTGCGGCAAGGCACCTATGCCACCCTGGACAGCAGCCTGGGCTGGCAGGCGACTGAACGGATGAACATTTCCGTCTATGTCGATAACCTGTTCGACCGTCGTTACCGTACCTATGGCTACATGAACGGCAGCAGCGCCGTCGCGCAGGTCAATATGGGTCGCACCGTCGGTATCAATACGCGAATTGATTTCTTCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"GI": "CAA86211.1", "sequence": "MKMTRLYPLALGGLLLPAIANAQTSQQDESTLVVTASKQSSRSASANNVSSTVVSAPELSDAGVTASDKLPRVLPGLNIENSGNMLFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTDVQSVELLRGPQGTLYGKSAQGGIINIVTQQPDSTPRGYIEGGVSSRDSYRSKFNLSGPIQDGLLYGSVTLLRQVDDGDMINPATGSDDLGGTRASIGNVKLRLAPDDQPWEMGFAASRECTRATQDAYVGWNDIKGRKLSISDGSPDPYMRRCTDSQTLSGKYTTDDWVFNLISAWQQQHYSRTFPSGSLIVNMPQRWNQDVQELRAATLGDARTVDMVFGLYRQNTREKLNSAYDMPTMPYLSSTGYTTAETLAAYSDLTWHLTDRFDIGGGVRFSHDKSSTQYHGSMLGNPFGDQGKSNDDQVLGQLSAGYMLTDDWRVYTRVAQGYKPSGYNIVPTAGLDAKPFVAEKSINYELGTRYETADVTLQAATFYTHTKDMQLYSGPVGMQTLSNAGKADATGVELEAKWRFAPGWSWDINGNVIRSEFTNDSELYHGNRVPFVPRYGAGSSVNGVIDTRYGALMPRLALNLVGPHYFDGDNQLRQGTYATLDSSLGWQATERMNISVYVDNLFDRRYRTYGYMNGSSAVAQVNMGRTVGINTRIDFF"}}}}, "ARO_category": {"36611": {"category_aro_name": "tetracycline resistance gene", "category_aro_cvterm_id": "36611", "category_aro_accession": "3000472", "category_aro_description": "Genes conferring resistance to tetracycline antibiotics."}, "36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}}, "ARO_name": "fyuA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40524", "model_name": "fyuA", "model_type_id": "40292"}, "2322": {"model_id": "2322", "ARO_accession": "3003834", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "gadE is a DNA-binding transcriptional activator that regulates the expression of genes involved in acid resistance. It is required for the expression of gadA and gadBC.", "model_sequences": {"sequence": {"3597": {"dna_sequence": {"fmax": "3658893", "fmin": "3658365", "accession": "NC_000913.3", "strand": "+", "sequence": "ATGATTTTTCTCATGACGAAAGATTCTTTTCTTTTACAGGGCTTTTGGCAGTTGAAAGATAATCACGAAATGATAAAAATCAATTCCCTGTCAGAGATCAAAAAAGTAGGCAATAAACCCTTCAAGGTTATCATTGATACCTATCACAATCATATCCTTGATGAAGAAGCGATTAAATTTCTGGAGAAATTAGATGCCGAGAGAATTATTGTTTTGGCACCTTATCACATCAGTAAACTAAAAGCTAAAGCGCCTATTTATTTTGTTAGCCGCAAAGAAAGTATCAAAAATCTTCTTGAGATTACTTATGGTAAACACTTGCCCCATAAGAATTCACAATTATGTTTTTCACATAATCAGTTCAAAATTATGCAACTGATTCTGAAAAATAAAAATGAAAGCAATATCACGTCGACGCTCAATATTTCGCAACAAACATTAAAGATTCAGAAATTCAACATTATGTACAAGCTGAAACTAAGACGTATGAGCGACATCGTCACCCTGGGTATCACATCTTATTTTTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_417969.1", "sequence": "MIFLMTKDSFLLQGFWQLKDNHEMIKINSLSEIKKVGNKPFKVIIDTYHNHILDEEAIKFLEKLDAERIIVLAPYHISKLKAKAPIYFVSRKESIKNLLEITYGKHLPHKNSQLCFSHNQFKIMQLILKNKNESNITSTLNISQQTLKIQKFNIMYKLKLRRMSDIVTLGITSYF"}}}}, "ARO_category": {"36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}, "36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}, "36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "35929": {"category_aro_name": "antibiotic resistance gene cluster, cassette, or operon", "category_aro_cvterm_id": "35929", "category_aro_accession": "0000010", "category_aro_description": "Clusters of antibiotic resistance genes. May be regulated by a shared promoter or repressor."}, "36611": {"category_aro_name": "tetracycline resistance gene", "category_aro_cvterm_id": "36611", "category_aro_accession": "3000472", "category_aro_description": "Genes conferring resistance to tetracycline antibiotics."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "gadE", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40525", "model_name": "gadE", "model_type_id": "40292"}, "2328": {"model_id": "2328", "ARO_accession": "3003842", "model_param": {"blastp_evalue": {"param_value": "1e-140", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "MUS-2 is a chromosome-encoded beta-lactamase from Myroides odoratimimus.", "model_sequences": {"sequence": {"3605": {"dna_sequence": {"fmax": "741", "fmin": "0", "accession": "NG_049325", "strand": "+", "sequence": "ATGCACAGAATACTTAGTGTCATAACGATGTTAATCTGTACTACATTAGTACACGCTCAATCTGACAAGCTAAAAATCAAACAACTCAATGATAATATGTATATATACACTACTTATCAAGAGTTTCAAGGAGTAACATACTCTTCTAATTCGATGTACGTACTGACAGATGAAGGTGCTATTCTAATAGACACACCTTGGGATAAAGATCAGTACGAACCTCTATTAGAGTACATCAGATCGAATCATAACAAAGAGGTTAAATGGGTCATCACTACCCACTTCCACGAAGATCGTTCTGGTGGATTAGGTTACTTTAACAGTATAGGAGCACAGACGTATACCTATGCATTGACCAATGAAATATTAAAAGAACGCAATGAACCACAAGCTCAATATTCTTTTAATAAAGAAAAACAGTTTACCTTTGGCAATGAGAAGTTGGCTGTATACTTTTTAGGAGAAGGACATTCACTAGATAATACCGTAGTCTGGTTTCCAAAAGAAGAAGTACTATACGGAGGGTGCCTGATTAAGAGTGCCGAAGCTACCACTATAGGTAATATAGCCGATGGTAACGTGATAGCTTGGCCTAAGACTATCGAAGCCGTAAAACAAAAATTTAAGAATGCTAAAGTCATTATACCAGGACATGATGAATGGGATATGATAGGGCATATCGAGAATACTGAGCGTATATTATCAGCATACAATCAACAACATTCAACTAAAAACGATTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Myroides odoratimimus", "NCBI_taxonomy_id": "76832", "NCBI_taxonomy_cvterm_id": "39072"}, "protein_sequence": {"GI": "WP_063860852", "sequence": "MHRILSVITMLICTTLVHAQSDKLKIKQLNDNMYIYTTYQEFQGVTYSSNSMYVLTDEGAILIDTPWDKDQYEPLLEYIRSNHNKEVKWVITTHFHEDRSGGLGYFNSIGAQTYTYALTNEILKERNEPQAQYSFNKEKQFTFGNEKLAVYFLGEGHSLDNTVVWFPKEEVLYGGCLIKSAEATTIGNIADGNVIAWPKTIEAVKQKFKNAKVIIPGHDEWDMIGHIENTERILSAYNQQHSTKND"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "MUS-2 beta-lactamase", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40535", "model_name": "MUS-2 beta-lactamase", "model_type_id": "40292"}, "2326": {"model_id": "2326", "ARO_accession": "3003204", "model_param": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "TLA-3 is a beta-lactamase found in a transferable plasmid of Serratia marcescens clinical isolate. It confers resistance to ceftazidime, cefotaxime and cefepime, but not to cefmetazole and meropenem", "model_sequences": {"sequence": {"3603": {"dna_sequence": {"fmax": "1030", "fmin": "100", "accession": "NG_050312", "strand": "+", "sequence": "ATGAAAAAACATCTTATTGTAATTGCATTTTGTGCGCTTTTTGCTTCTGCCTTTGCGGCTAAAGGTACGGATTCGCTTAAAAACAGTGCTAAAGGTACGGATTCGCTTAAAAACAGTATTGAAAAATATCTTAAAGATAAAAAAGCAAAAGTCGGTGTTGCCGTTTTGGGAATTGAAGATAATTTTAAATTGAACGTTAACGAAAAGCATCACTATCCTATGCAAAGTACTTATAAATTCCATTTAGCGTTGGCAGTGCTTGATAAACTTGATAAAGAGAATATTTCCGTTGACAAGAAGCTTTTTGTAAAGAAATCCGACCTTCAACCGAATACTTGGAGCCCGCTAAAAGATAAATATCCTAACGGAAATTTGGAATTGTCATTTAGTGAAATTATTAAGTCTACAGTTTCTCACAGCGATAACAACGGCTGCGATATTCTTTTCAGATTTGTCGGCGGAACAAATAAAGTCCACAATTTTATTAGCAAGCTTGGCGTTAAGAATATTTCTATCAAAGCTACAGAAGAAGAAATGCACAAGGCATGGAATGTACAATATACCAATTGGACAACTCCCGATGCTACCGTTCAGCTCTTAAAGAAGTTCTACAAAAATGAAATACTCTCAAAAAATAGTTACGACTTTTTGCTTAATACCATGATTGAAACTACTACCGGACCTAAACGACTCAAAGGACTTTTGCCGGATGGAACTGTTGTTGCGCATAAAACCGGAAGCTCAGATACTAACAATAAAGGAATTACTGCTGCCACAAATGATATCGGTATTATTACTTTGCCGAACGGCAAGCACTTTGCCATTGCTGTTTATGTGTCGGATTCAAGCGAAAAGAGCGATGTTAACGAAAAAATTATTGCCGAAATTTGCAAAAGCGTTTGGGATTATCTAGTTAAGGATGGGAAATAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacteriaceae", "NCBI_taxonomy_id": "543", "NCBI_taxonomy_cvterm_id": "40532"}, "protein_sequence": {"GI": "WP_059512353.1", "sequence": "MKKHLIVIAFCALFASAFAAKGTDSLKNSAKGTDSLKNSIEKYLKDKKAKVGVAVLGIEDNFKLNVNEKHHYPMQSTYKFHLALAVLDKLDKENISVDKKLFVKKSDLQPNTWSPLKDKYPNGNLELSFSEIIKSTVSHSDNNGCDILFRFVGGTNKVHNFISKLGVKNISIKATEEEMHKAWNVQYTNWTTPDATVQLLKKFYKNEILSKNSYDFLLNTMIETTTGPKRLKGLLPDGTVVAHKTGSSDTNNKGITAATNDIGIITLPNGKHFAIAVYVSDSSEKSDVNEKIIAEICKSVWDYLVKDGK"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "TLA-3", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39788", "model_name": "TLA-3", "model_type_id": "40292"}, "2323": {"model_id": "2323", "ARO_accession": "3003836", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "qacH is a subunit of the qac multidrug efflux pump in Vibrio cholerae", "model_sequences": {"sequence": {"3598": {"dna_sequence": {"fmax": "521", "fmin": "188", "accession": "DQ149925.1", "strand": "+", "sequence": "GTGAAGAACTGGATATTTATGGCTGTTGCAATCTTTGGCGAGGTCATCGCAACTTCCGCACTGAAGTCTAGCCATGGATTCACTAGGTTAGTTCCTTCCGTTGTAGTTGTGGCTGGCTACGGGCTTGCGTTCTATTTCTTGTCTCTCGCGCTCAAGTCCATTCCGGTCGGTATTGCTTACGCTGTATGGGCTGGGCTTGGCATCGTGCTTGTGGCAGCTATTGCTTGGATTTTCCATGGCCAAAAACTAGACTTCTGGGCGTTCATTGGCATGGGACTTATCGTCAGTGGCGTCGCCGTTCTAAACCTGCTATCCAAGGTCAGCGCACATTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Vibrio cholerae", "NCBI_taxonomy_id": "666", "NCBI_taxonomy_cvterm_id": "36789"}, "protein_sequence": {"GI": "AAZ42322.1", "sequence": "MKNWIFMAVAIFGEVIATSALKSSHGFTRLVPSVVVVAGYGLAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLDFWAFIGMGLIVSGVAVLNLLSKVSAH"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "qacH", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40527", "model_name": "qacH", "model_type_id": "40292"}, "2075": {"model_id": "2075", "ARO_accession": "3003382", "model_param": {"blastp_evalue": {"param_value": "1e-70", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"3900": "R20H", "3901": "G121D"}, "clinical": {"3900": "R20H", "3901": "G121D"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps.", "model_sequences": {"sequence": {"3574": {"dna_sequence": {"fmax": "4349963", "fmin": "4349504", "accession": "NC_003198.1", "strand": "+", "sequence": "ATGGAAAAAAAATCTCCCCGTTTAAAAGCCTTACTGACGCCGGGGGAAGTTGCGAAACGTAGCGGTGTTGCTGTGTCCGCCCTGCACTTCTATGAAAGCAAAGGGCTAATTACCAGTATCCGTAATAGCGGTAACCAACGGCGATACAAGCGTGACGTGTTGCGTTATGTCGCGATTATCAAGATTGCCCAGCGTATCGGCATCCCGCTGGCAACTATCGGCGACGCGTTTGGTATCTTGCCGGAAGGGCATACGTTAAGCGCGAAAGAGTGGAAGCAGCTCTCCTCGCAGTGGCGCGAAGAGTTAGACCGACGTATTCATACGCTGGTGGCGTTGCGCGATGAGCTGGACGGTTGTATCGGCTGCGGCTGTTTATCGCGTAGCGACTGTCCGCTGCGGAATCCAGGCGACAGGCTTGGCGAACACGGGACGGGCGCCCGGCTGCTTGAAGATGATTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Typhi str. CT18", "NCBI_taxonomy_id": "220341", "NCBI_taxonomy_cvterm_id": "35776"}, "protein_sequence": {"GI": "NP_458564.1", "sequence": "MEKKSPRLKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGDAFGILPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEHGTGARLLEDD"}}}}, "ARO_category": {"36537": {"category_aro_name": "chloramphenicol resistance gene", "category_aro_cvterm_id": "36537", "category_aro_accession": "3000398", "category_aro_description": "Genes conferring resistance to chloramphenicol."}, "36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}, "36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36611": {"category_aro_name": "tetracycline resistance gene", "category_aro_cvterm_id": "36611", "category_aro_accession": "3000472", "category_aro_description": "Genes conferring resistance to tetracycline antibiotics."}, "36522": {"category_aro_name": "rifampin resistance gene", "category_aro_cvterm_id": "36522", "category_aro_accession": "3000383", "category_aro_description": "Genetic determinants which confer resistance to rifampin."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "Salmonella enterica soxR mutants", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "39966", "model_name": "Salmonella enterica soxR mutants", "model_type_id": "40293"}, "2324": {"model_id": "2324", "ARO_accession": "3003838", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and, in situations where GadX is missing, activates gadA and gadBC.", "model_sequences": {"sequence": {"3599": {"dna_sequence": {"fmax": "2552440", "fmin": "2551711", "accession": "CP015085.1", "strand": "-", "sequence": "TCAGGAAAAGGTACCCGGCGAATGTTGCGAAAACTGATGTGGCGTTACACCATAATATTGTCTAAATGTATTTATAAAGTATGACGTACTGCTATAGCCACATTTTTCCGCAATAGTATGCAGAGGTATTTGACGTAACTCGAGTAATCGTCTGGCCATCGACATCCTGGAGGCGAGTAATATTTTACTGAAACAGGTATTTTCATCCTGCAACTTTTTTTTGATGAGACTCTCGCTGGTGTACATTCTTTCTGCGATATCGCGTAGATACCAACGTTTAGCGATATCAAAGCTAATAAGGCGTTCAACTTTTCCTGAAACAGTACTGATACTATTGAAAAGTAAGGGGATCAGTTCTTTCTTATGAGAAAACATTGATAAACAGGAAAGATAGAGCATTTTGCTCAGTATCGGCGAATTGACCCGGGGGTCATTGAAACTATCAAAAATCGCCGTCACCAGCTGTATGGGGGGTGACTGGTTAATTAACAAACGGTCTTTGCTATGCAATCCTAAATTGCGTGGCAACTGACGAATATTTTGTAAGTAATGGCAAACTGTCAGCTCTTCGATATCCAGCCGTCGCGTATCCAGTGAACAAAACGCAAAATCGTCTGCCAAATTTTTATCCAGCAGCAGGATACTCTCGTTATGCAACGATATTTTTTGCTGTTCATGATGAATATCGAATGAACGACGAACGAGGATCACCGAGCAGACATGAGCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli O25b:H4", "NCBI_taxonomy_id": "941280", "NCBI_taxonomy_cvterm_id": "40530"}, "protein_sequence": {"GI": "ANK04027.1", "sequence": "MAHVCSVILVRRSFDIHHEQQKISLHNESILLLDKNLADDFAFCSLDTRRLDIEELTVCHYLQNIRQLPRNLGLHSKDRLLINQSPPIQLVTAIFDSFNDPRVNSPILSKMLYLSCLSMFSHKKELIPLLFNSISTVSGKVERLISFDIAKRWYLRDIAERMYTSESLIKKKLQDENTCFSKILLASRMSMARRLLELRQIPLHTIAEKCGYSSTSYFINTFRQYYGVTPHQFSQHSPGTFS"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}, "36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "gadW", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40529", "model_name": "gadW", "model_type_id": "40292"}}}