Model_id Action ARO_name ARO_category Changes To Summary 2201 UPDATE PvrR gene conferring resistance via absence; aminoglycoside resistance gene; model_type; model_description "UPDATED model_type with protein knockout model UPDATED model_description with A model to detect cases where the absence of a protein due to large scale insertions or deletions confers elevated resistance to antibiotic(s). These models include reference sequences and a curated BLASTP cut-off. " 632 UPDATE PmrA polymyxin resistance gene; gene altering cell wall charge conferring antibiotic resistance; model_type; model_description; model_sequences; model_param; model_type_id "UPDATED model_type with protein variant model UPDATED model_description with A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants. UPDATED fmax with 5364736 UPDATED strand with + UPDATED accession with NC_002516.2 UPDATED fmin with 5364070 UPDATED sequence with ATGAGAATACTGCTGGCCGAGGACGACCTGCTGCTCGGCGACGGCATCCGCGCCGGGCTGCGCCTGGAAGGCGATACCGTGGAATGGGTGACCGACGGCGTGGCCGCGGAGAACGCGCTGGTCACCGACGAGTTCGACCTGCTGGTGCTCGACATCGGACTGCCGCGCCGCAGCGGCCTGGACATCCTGCGCAACCTGCGTCACCAGGGCCTGCTCACCCCGGTGCTGCTGCTCACCGCGCGGGACAAGGTGGCCGACCGGGTCGCCGGGCTCGACAGCGGTGCCGACGACTACCTGACCAAGCCCTTCGATCTCGACGAACTGCAGGCACGGGTGCGCGCCCTGACCCGCCGCACCACCGGTCGCGCCCTGCCGCAACTGGTGCACGGCGAGCTGCGCCTGGACCCGGCGACCCACCAGGTGACCCTGTCCGGGCAGGCGGTGGAACTGGCGCCGCGCGAATACGCACTGCTGCGCCTGCTGCTGGAGAACAGCGGCAAGGTGCTCTCGCGCAACCAACTGGAGCAGAGCCTCTACGGCTGGAGCGGCGACGTCGAGAGCAACGCCATCGAAGTCCACGTCCACCACCTGCGGCGCAAGCTCGGCAACCAGTTGATCCGCACCGTCCGCGGCATCGGCTACGGCATCGACCAGCCGGCGCCCTGA UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa PAO1 UPDATED NCBI_taxonomy_id with 208964 UPDATED NCBI_taxonomy_cvterm_id with 36804 UPDATED GI with NP_253464.1 UPDATED sequence with MRILLAEDDLLLGDGIRAGLRLEGDTVEWVTDGVAAENALVTDEFDLLVLDIGLPRRSGLDILRNLRHQGLLTPVLLLTARDKVADRVAGLDSGADDYLTKPFDLDELQARVRALTRRTTGRALPQLVHGELRLDPATHQVTLSGQAVELAPREYALLRLLLENSGKVLSRNQLEQSLYGWSGDVESNAIEVHVHHLRRKLGNQLIRTVRGIGYGIDQPAP UPDATED 4374 with L157Q UPDATED 4375 with L71R UPDATED 4374 with L157Q UPDATED 4375 with L71R UPDATED param_type with single resistance variant UPDATED param_type_id with 36301 UPDATED param_description with A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s). UPDATED model_type_id with 40293 " _timestamp N/A N/A N/A N/A NEW: 2016-08-04T17:32:21+00:00 , OLD: 2016-07-13T15:08:04+00:00 2317 UPDATE mgrB gene modulating antibiotic efflux; gene altering cell wall charge conferring antibiotic resistance; macrolide resistance gene; efflux pump conferring antibiotic resistance; gene conferring resistance via absence; polymyxin resistance gene; model_type; model_description "UPDATED model_type with protein knockout model UPDATED model_description with A model to detect cases where the absence of a protein due to large scale insertions or deletions confers elevated resistance to antibiotic(s). These models include reference sequences and a curated BLASTP cut-off. " _version N/A N/A N/A N/A NEW: 1.1.0 , OLD: 1.0.9 332 UPDATE r39 beta-lactamase antibiotic inactivation enzyme; beta-lactam resistance gene; ARO_description; model_param "UPDATED ARO_description with Class A beta-lactamase found in Actinomadura R39 UPDATED param_value with 1e-120 " 2003 UPDATE pmrA efflux pump efflux pump conferring antibiotic resistance; fluoroquinolone resistance gene; model_sequences; model_param "UPDATED fmax with 867410 UPDATED strand with + UPDATED accession with NC_003098.1 UPDATED fmin with 866210 UPDATED sequence with ATGACAGAGATTAACTGGAAGGATAATCTGCGTATTGCCTGGTTTGGTAATTTTCTGACAGGAGCCAGTATTTCTTTGGTTGTACCTTTTATGCCCATCTTCGTGGAAAATCTAGGTGTAGGGAGTCAGCAAGTCGCTTTTTATGCAGGCTTAGCAATTTCTGTCTCTGCTATTTCCGCGGCGCTCTTTTCTCCTATTTGGGGTATTCTTGCTGACAAATACGGCCGAAAACCCATGATGATTCGGGCAGGTCTTGCTATGACTATCACTATGGGAGGCTTGGCCTTTGTCCCAAATATCTATTGGTTAATCTTTCTTCGTTTACTAAACGGTGTATTTGCAGGTTTTGTTCCTAATGCAACGGCACTGATAGCCAGTCAGGTTCCAAAGGAGAAATCAGGCTCTGCCTTAGGTACTTTGTCTACAGGCGTAGTTGCAGGTACTCTAACCGGTCCCTTTATTGGTGGCTTTATCGCAGAATTATTTGGCATTCGTACAGTTTTCTTACTGGTTGGTAGTTTTCTATTTTTAGCTGCTATTTTGACTATTTGCTTTATCAAGGAAGATTTTCAACCAGTAGCCAAGGAAAAGGCTATTCCAACAAAGGAATTATTTACCTCGGTTAAATATCCCTATCTTTTGCTCAATCTCTTTTTAACCAGTTTTGTCATCCAATTTTCAGCTCAATCGATCGGCCCTATTTTGGCTCTTTATGTACGCGACTTAGGGCAGACAGAGAATCTTCTTTTTGTCTCTGGTTTGATTGTGTCCAGTATGGGCTTTTCCAGTATGATGAGTGCAGGAGTCATGGGCAAGCTAGGTGACAAGGTGGGCAATCATCGTCTCTTGGTTGTCGCCCAGTTTTATTCAGTCATCATCTATCTCCTCTGTGCCAATGCCTCTAGCCCCCTTCAACTAGGACTCTATCGTTTCCTCTTTGGCTTGGGAACCGGTGCCTTGATTCCAGGGGTTAATGCCCTACTCAGCAAAATGACTCCCAAAGCCGGCATTTCGAGGGTCTTTGCCTTCAATCAGGTATTCTTTTATCTGGGAGGTGTTGTTGGTCCCATGGCAGGTTCTGCAGTAGCAGGTCAATTTGGCTACCATGCTGTCTTTTATGCGACAAGCCTTTGTGTTGCCTTTAGTTGTCTCTTTAACCTGATTCAATTTCGAACATTATTAAAAGTAAAGGAAATCTAG UPDATED NCBI_taxonomy_name with Streptococcus pneumoniae R6 UPDATED NCBI_taxonomy_id with 171101 UPDATED NCBI_taxonomy_cvterm_id with 39596 UPDATED GI with NP_358469.1 UPDATED sequence with MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSQQVAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYWLIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAELFGIRTVFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLFLTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDKVGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPKAGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRTLLKVKEI UPDATED param_value with 1e-120 " 383 UPDATE phoQ efflux pump conferring antibiotic resistance; polymyxin resistance gene; macrolide resistance gene; gene modulating antibiotic efflux; gene altering cell wall charge conferring antibiotic resistance; ARO_accession; ARO_name; ARO_description; model_sequences; model_param; model_type; model_description; ARO_id; model_type_id "UPDATED ARO_accession with 3003896 UPDATED ARO_name with Pseudomonas mutant PhoQ conferring resistance to colistin UPDATED ARO_description with Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin UPDATED fmax with 1279708 UPDATED strand with + UPDATED accession with NC_002516.2 UPDATED fmin with 1278361 UPDATED sequence with GTGATCCGTTCCCTGCGCATCCGTCTGATGCTCGGCGCCGCCGCCCTGGCGGTGCTGTTCATGCTGGCGCTGCTGCCGGCCCTGCAGCGGGCCTTCGGCATCGCCCTGGAGAACACCATCGAGCAGCGCCTGGCCGCCGACGTGGCGACCCTGGTCTCGGCGGCGCGGGTGGAGAAGGGCCGCCTGGTGATGCCCGAGCACCTGCCGGTGGAGGAGTTCAACCTGCCGGAGGCCAAGGTCCTCGGCTATATCTACGACCAGAATGGCGATCTGCTCTGGCGCTCCACCTCGGCGGCCGACGAGTCGATCAACTACACGCCGCGCTACGACGGCCGCGGCAACGAATTCCACACCACCCGCGATGCGAAGGGCGAGGAGTTCTTCGTGTTCGACGTCGAGATCGACCTGCTGCGCGGCAAGCAGGCGGCCTACAGCATCGTCACCATGCAATCGGTCAGCGAGTTCGAGAGCCTGCTCAAGGGGTTCCGCGAGCAGCTCTACCTGTGGCTCGGCGGCGCCCTGCTGGTCTTGCTCGGGCTGCTCTGGCTGGGTCTGACCTGGGGCTTCCGGGCGATGCGCGGGTTGAGTTCCGAGCTGGACCAGATCGAATCCGGCGAGCGCGAGAGCCTGAGCGAGGAGCATCCGCGCGAGCTGCTGCGCCTGACCCACTCGCTTAACCGCCTGTTGCGCAGCGAGCACAAACAGCGCGAGCGCTACCGCCACTCCCTCGGCGACCTGGCGCACAGTCTGAAGACGCCGCTGGCGGTCTTGCAGGGGGTCGGCGACCAGCTCGCCGAGGAGCCCGGCAACCGCGAGCAGGTGCGGGTGCTACAGGGCCAGATCGAGCGCATGAGCCAGCAGATAGGCTATCAGTTGCAGCGCGCCAGCCTGCGCAAGAGCGGCCTGGTACGCCATCGCGAGCAACTGGCGCCGCTGGTGGAGACCCTGTGCGACGCGCTGGACAAGGTCTATCGCGACAAGCGGGTAAGCCTGCAGCGGGACTTCTCGCCGTCCTTCAGCGTGCCGGTGGAGCGCGGCGCGCTGCTGGAACTGCTCGGCAACCTGCTGGAGAACGCCTATCGCCTGTGCCTGGGCCGGGTCCGCGTGGGCGCCCGGCTGGGGCCGGGTTACTCGGAGCTGTGGGTCGAGGACGACGGTCCCGGAGTGCCTGCCGAACAGCGCGCACGAATCATCCGCCGCGGCGAGCGCGCCGATACCCAGCACCCGGGGCAGGGCATCGGCCTGGCCGTGGCGCTGGACATCATCGAGAGCTACGACGGCGAACTGAGCCTGGACGATTCCGAGCTGGGCGGCGCCTGCTTCCGCATACGTTTCGCTACAGTCTGA UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa PAO1 UPDATED NCBI_taxonomy_id with 208964 UPDATED NCBI_taxonomy_cvterm_id with 36804 UPDATED GI with NP_249871.1 UPDATED sequence with MIRSLRIRLMLGAAALAVLFMLALLPALQRAFGIALENTIEQRLAADVATLVSAARVEKGRLVMPEHLPVEEFNLPEAKVLGYIYDQNGDLLWRSTSAADESINYTPRYDGRGNEFHTTRDAKGEEFFVFDVEIDLLRGKQAAYSIVTMQSVSEFESLLKGFREQLYLWLGGALLVLLGLLWLGLTWGFRAMRGLSSELDQIESGERESLSEEHPRELLRLTHSLNRLLRSEHKQRERYRHSLGDLAHSLKTPLAVLQGVGDQLAEEPGNREQVRVLQGQIERMSQQIGYQLQRASLRKSGLVRHREQLAPLVETLCDALDKVYRDKRVSLQRDFSPSFSVPVERGALLELLGNLLENAYRLCLGRVRVGARLGPGYSELWVEDDGPGVPAEQRARIIRRGERADTQHPGQGIGLAVALDIIESYDGELSLDDSELGGACFRIRFATV UPDATED param_value with 1e-120 UPDATED 4370 with K123Q UPDATED 4371 with V260G UPDATED param_type_id with 36301 UPDATED param_type with single resistance variant UPDATED param_description with A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s). UPDATED 4370 with K123Q UPDATED 4371 with V260G UPDATED model_type with protein variant model UPDATED model_description with A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants. UPDATED ARO_id with 40598 UPDATED model_type_id with 40293 " 1600 UPDATE phoP efflux pump conferring antibiotic resistance; polymyxin resistance gene; macrolide resistance gene; gene modulating antibiotic efflux; gene altering cell wall charge conferring antibiotic resistance; ARO_accession; ARO_name; ARO_description; model_sequences; model_param; model_type; model_description; ARO_id; model_type_id "UPDATED ARO_accession with 3003895 UPDATED ARO_name with Pseudomonas mutant PhoP conferring resistance to colistin UPDATED ARO_description with Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. UPDATED fmax with 1278365 UPDATED strand with + UPDATED accession with NC_002516.2 UPDATED fmin with 1277687 UPDATED sequence with ATGAAACTGCTGGTAGTGGAAGACGAGGCGCTGTTGCGCCACCACCTCTATACCCGCCTGGGTGAACAGGGGCACGTGGTGGACGCGGTACCGGATGCCGAGGAAGCCCTCTACCGGGTCAGCGAATACCACCACGACCTGGCGGTGATCGACCTCGGCCTGCCGGGCATGAGCGGCCTGGACCTGATCCGCGAGCTGCGTTCGCAGGGCAAGTCCTTCCCGATCCTGATCCTCACCGCCCGCGGCAACTGGCAGGACAAGGTCGAAGGCCTGGCCGCCGGGGCCGACGACTACGTGGTCAAGCCGTTCCAGTTCGAGGAACTGGAAGCGCGCCTGAACGCGTTGCTGCGACGCTCCTCGGGGTTCGTCCAGTCGACCATCGAGGCCGGCCCCCTGGTCCTCGACCTGAACCGCAAGCAGGCGCTGGTCGAGGAGCAACCGGTGGCGCTGACCGCCTACGAATACCGCATCCTCGAATACCTCATGCGGCATCACCAGCAGGTGGTGGCCAAGGAACGCCTGATGGAACAGCTCTATCCCGACGACGAGGAGCGCGACGCCAACGTCATCGAGGTGCTGGTCGGCCGCCTGCGGCGCAAGCTGGAGGCCTGCGGCGGCTTCAAGCCGATCGATACGGTGCGCGGCCAGGGCTACCTGTTCACCGAGCGCTGCCGGTGA UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa PAO1 UPDATED NCBI_taxonomy_id with 208964 UPDATED NCBI_taxonomy_cvterm_id with 36804 UPDATED GI with NP_249870.1 UPDATED sequence with MKLLVVEDEALLRHHLYTRLGEQGHVVDAVPDAEEALYRVSEYHHDLAVIDLGLPGMSGLDLIRELRSQGKSFPILILTARGNWQDKVEGLAAGADDYVVKPFQFEELEARLNALLRRSSGFVQSTIEAGPLVLDLNRKQALVEEQPVALTAYEYRILEYLMRHHQQVVAKERLMEQLYPDDEERDANVIEVLVGRLRRKLEACGGFKPIDTVRGQGYLFTERCR UPDATED param_value with 1e-120 UPDATED 4367 with R117L UPDATED 4368 with A110V UPDATED param_type_id with 36301 UPDATED param_type with single resistance variant UPDATED param_description with A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s). UPDATED 4367 with R117L UPDATED 4368 with A110V UPDATED model_type with protein variant model UPDATED model_description with A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants. UPDATED ARO_id with 40597 UPDATED model_type_id with 40293 " 1912 UPDATE LRA-13 antibiotic inactivation enzyme; beta-lactam resistance gene; ARO_description "UPDATED ARO_description with LRA-13 is a class D/class C fusion bifunctional beta-lactamase isolated from soil samples in Alaska. " 1670 UPDATE nalC chloramphenicol resistance gene; gene modulating antibiotic efflux; beta-lactam resistance gene; macrolide resistance gene; fluoroquinolone resistance gene; efflux pump conferring antibiotic resistance; aminocoumarin resistance gene; tetracycline resistance gene; polymyxin resistance gene; trimethoprim resistance gene; model_type; model_description; model_param; model_type_id "UPDATED model_type with protein variant model UPDATED model_description with A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants. UPDATED 4364 with R97G UPDATED 4366 with A186T UPDATED 4363 with S209R UPDATED 4364 with R97G UPDATED 4366 with A186T UPDATED 4363 with S209R UPDATED param_type with single resistance variant UPDATED param_type_id with 36301 UPDATED param_description with A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s). UPDATED model_type_id with 40293 " 1348 DELETE cphA1 antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2269 DELETE Escherichia coli nfsB mutations conferring resistance to nitrofurantoin nitrofuratoin resistance gene; antibiotic resistant gene variant or mutant; N/A N/A 2375 ADD Rm3 beta-lactamase antibiotic inactivation enzyme; beta-lactam resistance gene; N/A N/A 2372 ADD Escherichia coli mutant GlpT conferring resistance to fosfomycin fosfomycin resistance gene; antibiotic resistant gene variant or mutant; N/A N/A 2373 ADD Escherichia coli mutant UhpT conferring resistance to fosfomycin fosfomycin resistance gene; antibiotic resistant gene variant or mutant; N/A N/A