{"$update": {"150": {"$update": {"model_sequences": {"$update": {"sequence": {"3699": {"dna_sequence": {"fmax": "58833", "fmin": "58200", "accession": "NC_019368.1", "strand": "+", "sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGAGCCTTACGCTATCGTTGGCGGCAATCCCGCTAAGAAGATTAAGAAACGCTTCACCGATGAGGAAATTTCATTGCTTCTGGAGATGGAGTGGTGGAATTGGTCACTGGAGAAGATCAAAGCGGCAATGCCCATGCTGTGCTCGTCTAATATTGTTGGCCTGCACAAGTATTGGCTCGAGTTTGCCGTCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550", "NCBI_taxonomy_cvterm_id": "36884"}, "protein_sequence": {"GI": "YP_006965431.1", "sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVEPYAIVGGNPAKKIKKRFTDEEISLLLEMEWWNWSLEKIKAAMPMLCSSNIVGLHKYWLEFAV"}}}}}}}, "621": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["595", "594"]}}}}}, "45": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3304", "3305"]}}}}}, "1952": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["797"]}}}}}, "1201": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "780": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "333": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "_version": "1.1.1", "273": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1486": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "113": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "821": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3328", "3331"]}}}}}, "83": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3320"]}}}}}, "138": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["754"]}}}, "ARO_name": "Streptomyces lividans cml"}}, "823": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["450", "452", "453", "444", "443", "438", "432", "441"]}}}}}, "255": {"$update": {"model_sequences": {"$update": {"sequence": {"3682": {"dna_sequence": {"fmax": "10249", "fmin": "9883", "accession": "NC_020818.1", "strand": "+", "sequence": "ATGGCTGACCACGTCACCCCCAATCTGCCATCGCGCGATTTCGATGTGACAGAGGCGTTTTATGCGAAGCTGGGCTTTGCGACGAGTTGGAAGGATCGCGGCTGGATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"GI": "YP_007652797.1", "sequence": "MADHVTPNLPSRDFDVTEAFYAKLGFATSWKDRGWMILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD"}}}}}}}, "1830": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["542", "543"]}}}}}, "696": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3287", "3288"]}}}}}, "1811": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["1097"]}}}, "model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "2056": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3302", "3301"]}}}}}, "2242": {"$update": {"ARO_description": "VanWI is a vanW variant found in the vanI gene cluster"}}, "1192": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3418"]}}}, "model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "2222": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1118": {"$update": {"model_sequences": {"$update": {"sequence": {"3720": {"dna_sequence": {"fmax": "828", "fmin": "0", "accession": "M95287.4", "strand": "+", "sequence": "CTTTAATTATACCTTTGTGTTATTTGTGGATTGTGCAGCTCAGTGGGGCGCTGGCCGTGACGGTGCGGTGTCCCCCGTAACCGGCCGCGCGGCGGCCGCTAACTCGCAGTACGGCGCCGCGACCCGCAGGCGGGCCGCCGTACCCGCGCGCAGGCGCGCGGCGCCCACTGCGCACCCCCGTGGAGGACGTGCGGCAGCTGCGTGGCGGCGGGCTGGGTTATGGCTTAGCAGGGAGGGGGGTTGGCCTGTTGCTCCGGTCAGTCCCGCAGTTTCCGGCGATTTGCGGCCGGTGTCCGGTGGAGTCCGGCGCGGTCGCCTTCCATGCCCTGACGGGCATATGGCGGCACATCGCATTCGACGAAACCCAACCTAACCGGAGTCATCAGGCTAGAATGTTATTCATCATTTATTTTCTCTGAATGGTTGCCTTTTGTCGTGTAGCGATAAATAGTCATGCGAGAAACATTGAAGCGCTTCGCAACAGCTCCTACTGTCATTTCAGGATCAGCAAGCAGAATTTTCATTTGCTTAATATCATCTTCCGAAAGTGACGGTTTTCTTCCCCCTACACGGCCCCTTGCGCGAGCAGCTGCGAGTCCAGATCTCGTTCGTTCAATATTGCGGTTGCGTTCAAAGTTAGAGAATATAGCCATCAGATGAGTATAGATTTCCCCGATAACAGGAGCGCTAGTATCTATTCTGTCTTTGATGGCTATAAAGGTGATTCCGCGCTTTTTCAGGTCGTCAAGCAACGTAATCACCTGGCTCAATGAACCGCCGAGCCGATCAAGCGCCCAAACAACCAGGGTATCACCTTCGCGCAATGCC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Plasmid R46", "NCBI_taxonomy_id": "2488", "NCBI_taxonomy_cvterm_id": "36846"}, "protein_sequence": {"GI": "AAB59082.1", "sequence": "MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR"}}}}}}}, "919": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["817"]}}}}}, "1442": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3299"]}}}}}, "1117": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["241"]}}}}}, "639": {"$update": {"ARO_description": "AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri", "model_sequences": {"$update": {"sequence": {"3715": {"dna_sequence": {"fmax": "777", "fmin": "0", "accession": "DQ241380.1", "strand": "+", "sequence": "GTGCAATACGAATGGCGAAAAGCCGAGCTCATCGGTCAGCTTCTCAACCTTGGGGTTACCCCCGGCGGTGTGCTGCTGGTCCACAGCTCCTTCCGTAGCGTCCGGCCCCTCGAAGATGGGCCACTTGGACTGATCGAGGCCCTGCGTGCTGCGCTGGGTCCGGGAGGGACGCTCGTCATGCCCTCGTGGTCAGGTCTGGACGACGAGCCGTTCGATCCTGCCACGTCGCCCGTTACACCGGACCTTGGAGTTGTCTCTGACACATTCTGGCGCCTGCCAAATGTAAAGCGCAGCGCCCATCCATTTGCCTTTGCGGCAGCGGGGCCACAGGCAGAGCAGATCATCTCTGATCCATTGCCCCTGCCACCTCACTCGCCTGCAAGCCCGGTCGCCCGTGTCCATGAACTCGATGGGCAGGTACTTCTCCTCGGCGTGGGACACGATGCCAACACGACGCTGCATCTTGCCGAGTTGATGGCAAAGGTTCCCTATGGGGTGCCGAGACACTGCACCATTCTTCAGGATGGCAAGTTGGTACGCGTCGATTATCTCGAGAATGACCACTGCTGTGAGCGCTTTGCCTTGGCGGACAGGTGGCTCAAGGAGAAGAGCCTTCAGAAGGAAGGTCCAGTCGGTCATGCCTTTGCTCGGTTGATCCGCTCCCGCGACATTGTGGCGACAGCCCTGGGTCAACTGGGCCGAGATCCGTTGATCTTCCTGCATCCGCCAGAGGCGGGATGCGAAGAATGCGATGCCGCTCGCCAGTCGATTGGCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"GI": "ABB43029.1", "sequence": "MQYEWRKAELIGQLLNLGVTPGGVLLVHSSFRSVRPLEDGPLGLIEALRAALGPGGTLVMPSWSGLDDEPFDPATSPVTPDLGVVSDTFWRLPNVKRSAHPFAFAAAGPQAEQIISDPLPLPPHSPASPVARVHELDGQVLLLGVGHDANTTLHLAELMAKVPYGVPRHCTILQDGKLVRVDYLENDHCCERFALADRWLKEKSLQKEGPVGHAFARLIRSRDIVATALGQLGRDPLIFLHPPEAGCEECDAARQSIG"}}}}}, "model_name": "AAC(3)-IV", "ARO_name": "AAC(3)-IV"}}, "1443": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "917": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["831"]}}}}}, "1031": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["466"]}}}}}, "467": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "1405": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["749"]}}}}}, "1363": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "1094": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "587": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3323"]}}}}}, "737": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3326"]}}}}}, "522": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["102", "98"]}}}}}, "898": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "613": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "2282": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-100"}}}}}}, "2283": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-160"}}}}}}, "26": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "1135": {"$update": {"model_sequences": {"$update": {"sequence": {"3681": {"dna_sequence": {"fmax": "2376", "fmin": "384", "accession": "D67075.1", "strand": "+", "sequence": "ATGAATAAACAAAATAATTATTCAGATGATTCAATACAGGTTTTAGAGGGGTTAGAAGCAGTTCGTAAAAGACCTGGTATGTATATTGGATCAACTGATAAACGGGGATTACATCATCTAGTATATGAAATTGTCGATAACTCCGTCGATGAAGTATTGAATGGTTACGGTAACGAAATAGATGTAACAATTAATAAAGATGGTAGTATTTCTATAGAAGATAATGGACGTGGTATGCCAACAGGTATACATAAATCAGGTAAACCGACAGTCGAAGTTATCTTTACTGTTTTACATGCAGGAGGTAAATTTGGACAAGGCGGCTATAAAACTTCAGGTGGTCTTCACGGTGTTGGTGCTTCAGTTGTAAATGCATTGAGTGAATGGCTTGAAGTTGAAATCCATCGAGATGGTAATATATATCATCAAAGTTTTAAAAACGGTGGTTCGCCATCTTCTGGTTTAGTGAAAAAAGGTAAAACTAAGAAAACAGGTACCAAAGTAACATTTAAACCTGATGACACAATTTTTAAAGCATCTACATCATTTAATTTTGATGTTTTAAGTGAACGACTACAAGAGTCTGCGTTCTTATTGAAAAATTTAAAAATAACGCTTAATGATTTACGCAGTGGTAAAGAGCGTCAAGAGCATTACCATTATGAAGAAGGAATCAAAGAGTTTGTTAGTTATGTCAATGAAGGAAAAGAAGTTTTGCATGACGTGGCTACATTTTCAGGTGAAGCAAATGGTATAGAGGTAGACGTAGCTTTCCAATATAATGATCAATATTCAGAAAGTATTTTAAGTTTTGTAAATAATGTACGTACTAAAGATGGTGGTACACATGAAGTTGGTTTTAAAACAGCAATGACACGTGTATTTAATGATTATGCACGTCGTATTAATGAACTTAAAACAAAAGATAAAAACTTAGATGGTAATGATATTCGTGAAGGTTTAACAGCTGTTGTGTCTGTTCGTATTCCAGAAGAATTATTGCAATTTGAAGGACAAACGAAATCTAAATTGGGTACTTCTGAAGCTAGAAGTGCTGTTGATTCAGTTGTTGCAGACAAATTGCCATTCTATTTAGAAGAAAAAGGACAATTGTCTAAATCACTTGTGAAAAAAGCGATTAAAGCACAACAAGCAAGGGAAGCTGCACGTAAAGCTCGTGAAGATGCTCGTTCAGGTAAGAAAAACAAGCGTAAAGACACTTTGCTATCTGGTAAATTAACACCTGCACAAAGTAAAAACACTGAAAAAAATGAATTGTATTTAGTCGAAGGTGATTCTGCGGGAGGTTCAGCAAAACTTGGACGAGACCGCAAATTCCAAGCGATATTACCATTACGTGGTAAGGTAATTAATACAGAGAAAGCACGTCTAGAAGATATTTTTAAAAATGAAGAAATTAATACAATTATCCACACAATCGGGGCAGGCGTTGGTACTGACTTTAAAATTGAAGATAGTAATTATAATCGTGTAATTATTATGACTGATGCTGATACTGATGGTGCGCATATTCAAGTGCTATTGTTAACATTCTTCTTCAAATATATGAAACCGCTTGTTCAAGCAGGTCGTGTATTTATTGCTTTACCTCCACTTTATAAATTGGAAAAAGGTAAAGGCAAAACAAAGCGAGTTGAATACGCTTGGACAGACGAAGAGCTTAATAAATTGCAAAAAGAACTTGGTAAAGGCTTCACGTTACAACGTTACAAAGGTTTGGGTGAAATGAACCCTGAGCAATTATGGGAAACGACGATGAACCCAGAAACACGAACTTTAATTCGTGTACAAGTTGAAGATGAAGTGCGTTCATCTAAACGTGTAACAACATTAATGGGTGACAAAGTACAACCTAGACGTGAATGGATTGAAAAGCATGTTGAGTTTGGTATGCAAGAGGACCAAAGTATTTTAGATAATTCTGAAGTACAAGTGCTTGAAAATGATCAATTTGATGAGGAGGAAATCTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus RN4220", "NCBI_taxonomy_id": "561307", "NCBI_taxonomy_cvterm_id": "35597"}, "protein_sequence": {"GI": "BAA11086.1", "sequence": "MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI"}}}}}, "model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-170"}}, "snp": {"$update": {"param_value": {"$delete": ["2192"], "$insert": {"4410": "G78S"}}, "clinical": {"$delete": ["2192"], "$insert": {"4410": "G78S"}}}}}}}}, "446": {"$update": {"model_sequences": {"$update": {"sequence": {"3700": {"dna_sequence": {"fmax": "1444", "fmin": "811", "accession": "NG_035647.1", "strand": "+", "sequence": "ATGAAAAACTACTTTAACAGCCCTTTCAAAGGGGAACTTCTTTCTGAGCAAGTGAAAAATCCAAATATCAGAGTAGGCCGGTATAGCTATTACTCTGGCTACTATCACGGGCACTCATTTGATGAATGCGCGCGATACTTGCTTCCAGATCGTGATGACGTTGATAAATTGATCATTGGCAGCTTTTGTTCTATAGGAAGCGGGGCTTCCTTCATCATGGCTGGCAATCAGGGGCATCGGCATGACTGGGCATCATCCTTCCCCTTCTTCTATATGCAAGAGGAGCCTGCTTTCTCAAGAGCACTCGACGCCTTCCAAAGAGCAGGTGATACCGTCATTGGCAATGATGTCTGGATAGGCTCGGAGGCAATGATTATGCCTGGCATCAAAATTGGAGACGGTGCCGTGATAGGTAGTCGCTCGTTGGTGACAAAAGATGTAGAGCCTTATGCCATCATCGGGGGAAATCCCGCAAAGCAAATTAAGAAGCGCTTCTCCGATGAGGAAATCTCATTGCTCATGGAGATGGAGTGGTGGAACTGGCCACTAGATAAAATTAAGACAGCAATGCCTCTGCTGTGCTCGTCAAATATTTTTGGTCTGCATAAGTATTGGCGCGAGTTTGCCGTCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Typhi", "NCBI_taxonomy_id": "90370", "NCBI_taxonomy_cvterm_id": "35731"}, "protein_sequence": {"GI": "YP_009077553.1", "sequence": "MKNYFNSPFKGELLSEQVKNPNIRVGRYSYYSGYYHGHSFDECARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWASSFPFFYMQEEPAFSRALDAFQRAGDTVIGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTKDVEPYAIIGGNPAKQIKKRFSDEEISLLMEMEWWNWPLDKIKTAMPLLCSSNIFGLHKYWREFAV"}}}}}}}, "1795": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "264": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3297"]}}}}}, "1499": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "513": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "105": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "10": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "39": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["269"]}}}}}, "_timestamp": "2016-10-05T13:13:32+00:00", "906": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "1558": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-160"}}}}}}, "2279": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-160"}}}}}}, "969": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-140"}}}}}}, "641": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "1105": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["658"]}}}}}, "533": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "2039": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "1745": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3377"]}}}}}, "1478": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "515": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["312"]}}}, "model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-120"}}}}}}, "293": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3321"]}}}}}, "1661": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}, "368": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}}}}}}, "$insert": {"2134": {"model_id": "2134", "ARO_accession": "3002047", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "CMY-36 is a beta-lactamase found in Klebsiella pneumoniae", "model_sequences": {"sequence": {"3695": {"dna_sequence": {"fmax": "3520", "fmin": "2374", "accession": "EU331426.1", "strand": "+", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACTGTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCTTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCAGAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCACAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"GI": "ABY58049.1", "sequence": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "CMY-36", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "38447", "model_name": "CMY-36", "model_type_id": "40292"}, "2135": {"model_id": "2135", "ARO_accession": "3001853", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "ACT-33 is a beta-lactamase. From the Lahey list of ACT beta-lactamases.", "model_sequences": {"sequence": {"3684": {"dna_sequence": {"fmax": "1146", "fmin": "0", "accession": "KM087834.1", "strand": "+", "sequence": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTAGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCACATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550", "NCBI_taxonomy_cvterm_id": "36884"}, "protein_sequence": {"GI": "AIT76087.1", "sequence": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILDALQ"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "ACT-33", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "38253", "model_name": "ACT-33", "model_type_id": "40292"}, "2130": {"model_id": "2130", "ARO_accession": "3003037", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "OpcM is an outer membrane factor protein found in Burkholderia cepacia. It is part of the CeoAB-OpcM complex.", "model_sequences": {"sequence": {"3687": {"dna_sequence": {"fmax": "1536", "fmin": "0", "accession": "U38944.1", "strand": "+", "sequence": "ATGGACAACATGCACAACACGAACGGCCTGATGCGCTTCGCGAAGGTGGCGGCCGCGAGCACCCTGCTCGCGACGCTGCTCGCCGCGTGTGCGGTCGGCCCCGACTACCAGCGTCCCGACGCGGTGGTGCCCGCCGCGTTCAAGGAAGCGCCGACCCTCGCCGCCGGCGAGCAGGCCGGCACGTGGAAGACGGCCGAGCCGTCGGATGGCCGAACACCGCGGCGAATGGTGAAGGTGTTCGGCGACCCGGTGCTCGATTCGCTCGAGACGCAGGCGCTTGCCGCGAACCAGAACCTGAAGGCCGCGGCCGCGCGGGTCGAGGAAGCGCGGGCGGCGACGCGTTCGGCGCGCTCGCAATGGTTCCCGCAGGTCGGCGCCGGTTTCGGGCCGACGCGCGAGGGGCTGTCGTCGGCGTCGCAGTTCCAGCCGCAGGGCACCGGCCCGACCAACGCGACGCTGTGGCGCGCGCAGGGCACGGTGTCGTACGAAGCCGATCTGTTCGGCCGCGTCGGCCGCAACGTCGAGGCGTCGCGTGCCGATCAGGCGCAGAGCGAAGCGCTGTTCCGTTCGGTGCAGCTCGCGCTGCAGGCCGACGTCGCGCAGAACTACTTCGAACTGCGTCAGCTCGATTCGGACCAGGACCTGTACCACCGCACGGTCGAGTTGCGCGAGCAGGCACTGAAGCTCGTGCAGCGCCGCTTCAACGAAGGCGACATCAGCGAGCTCGACGTGTCGCGCGCGAAGAACGAACTGGCGAGCGCGCAGGCCGATGCGGTCGACGTCGCGCGCCGGCGCGCGGCGTCCGAGCATGCGCTCGCCATCCTGCTCGGCAAGGCGCCCGCGGATTTCGCGTTCAAGGAAACGCCGATCGTGCCGGTCGCGGTGAAGATTCCGCCGGGCCTGCCGTCCGCGCTGCTCGAACGCCGCCCGGACGTGTCGGCGGCCGAACGCGCGATGGCGGCCGCGAACGCGCGGATCGGGCTCGCGAAGTCGGCGTACTTCCGAAGCTCGATATCACCGGGTCGTTCGGCTATAAGCGTCGACGCTCGGCAACCTGTTCCTGTGGTCGAGCCGTACTTCCTGCTCGGGCCGTTCGCCGGTACCGCGCTGACGTTGCCGCTGTTCGACGGCGGACGGCGGGCGGCCGGCGTGCAGCAGGCGCGCGCGCAGTACGACGAGCAGGGCGCGAACTACCGGCAGCAGGTGCTCGTCGCGTTCCGCGAGGTCGAGGACAATCTCGCCGATCTGCGTTTGCTCGATGATCAGATCCGCGCGCAGGAGGCGGCCGTCAATGCGTCGCGCCGGGCGGCGACGTTGTCGCGCAGCGAATATCAGGAAGGCGAGGTCGCATATCTCGACGTGATCGACAGCGAGCGCTCGGTGCTGCAGTCGCAGTTGCAGGCGAACCAGTTGACGGGTGCGCAGGCGGTGTCGACCGTCAATCTGATCCGTGCGCTGGGCGGCGGGTGGGGGAATGCGCCGGCGCCGACGGCGGTGGGTGATGCGGCGTCTGGCAAGGCTGACGTAGCTGCGCGG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Burkholderia cepacia", "NCBI_taxonomy_id": "292", "NCBI_taxonomy_cvterm_id": "36822"}, "protein_sequence": {"GI": "AAC43969.1", "sequence": "MDNMHNTNGLMRFAKVAAASTLLATLLAACAVGPDYQRPDAVVPAAFKEAPTLAAGEQAGTWKTAEPSDGRTPRRMVKVFGDPVLDSLETQALAANQNLKAAAARVEEARAATRSARSQWFPQVGAGFGPTREGLSSASQFQPQGTGPTNATLWRAQGTVSYEADLFGRVGRNVEASRADQAQSEALFRSVQLALQADVAQNYFELRQLDSDQDLYHRTVELREQALKLVQRRFNEGDISELDVSRAKNELASAQADAVDVARRRAASEHALAILLGKAPADFAFKETPIVPVAVKIPPGLPSALLERRPDVSAAERAMAAANARIGLAKSAYFRSSISPGRSAISVDARQPVPVVEPYFLLGPFAGTALTLPLFDGGRRAAGVQQARAQYDEQGANYRQQVLVAFREVEDNLADLRLLDDQIRAQEAAVNASRRAATLSRSEYQEGEVAYLDVIDSERSVLQSQLQANQLTGAQAVSTVNLIRALGGGWGNAPAPTAVGDAASGKADVAAR"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "opcM", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39471", "model_name": "opcM", "model_type_id": "40292"}, "2407": {"model_id": "2407", "ARO_accession": "3003931", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4461": "G80N"}, "clinical": {"4461": "G80N"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutation in Capnocytophaga gingivalis that decreases binding affinity of fluoroquinolone antibiotics to gyrA, thereby conferring resistance.", "model_sequences": {"sequence": {"3733": {"dna_sequence": {"fmax": "26749", "fmin": "24238", "accession": "ACLQ01000019.1", "strand": "+", "sequence": "ATGGTTGAAGGAGAAAAACTCATTCCTATTAACATAGAAGACCAGATGAAGACAGCCTACATTGACTATTCAATGTCAGTGATTGTCTCAAGAGCTTTGCCCGATGTACGCGATGGGCTGAAGCCTGTACATCGTCGTGTACTCTTTGGAATGCACGAGCTTGGCGTACGTAGCAACACCGCTCATAAGAAATCAGCCCGTATCGTAGGGGAAGTACTCGGTAAGTACCATCCACACGGCGATTCTTCCGTATATGACACAATGGTACGTATGGCACAATGGTGGAACATGCGCTATATGCTTGTAGATGGGCAAGGTAACTTTGGTTCTATCGATGGAGACTCTCCTGCAGCTATGCGTTATACCGAGGCGAGAATGAGAAAAATGGCCGAGGATATGCTGATAGATATCGACAAAGAAACAGTAGATCACAGCCTGAACTTTGACGATACCCTACTCGAACCTACTGTATTGCCTACCCGCATCCCTAACCTACTGGTGAATGGGTCTTCGGGTATTGCTGTAGGTATGGCTACCAATATGCCACCTCATAATCTTGCTGAAGTAGTTGATGGTATAATTGCTTATCTTGGCAATCAAGATATTACCATCGATGAACTTATGGAATATATCAAGGCTCCTGACTTCCCTACAGGTGGAATCATCTATGGCTATGATGGAGTAAGAGAAGCCTTCAAGACTGGACGTGGACGTGTAGTAATCCGCGCCAAGGCTCATTTTGAAGAAGTTAATGGTCGTGACTGTATTGTCGTAACTGAAGTTCCCTATCAAGTGAACCCAGAGACGATGCGTGAACAGACTTCGAACCTTGTCAAAGAAGGCAAACTCGAAGGCCTAGCCGATATCGTAGATCAAACAGGTAAAGGAGGAATGCGCATCGTATATGAACTCAAAAAAGATGCTATTCCCAACGTAGTGCTGAATAACCTCTTCAAACACACAGCATTACAATCCTCCTTCAGTGTCAATAATATTGCCTTGGTCAATGGACGCCCTCAGCAACTGAACCTCAAGGACTTAATATATCACTTTGTAGAACATCGCCACGATGTAGTATACAGACGTACTGAGTATGAGCTCAAAAAAGCCAAAGAACGTATCCATATCTTGGAAGGGTTCATGAAGGTGATGGCCACAGAAGACACTATGGGGAAAGCTATTGAAATCATCCGTTTTCATGACAAGCCCAAAGAGGATTTGATGACCGAGTTCGAGCTTACCGAAATACAAGCTGAAGCTATCTTAGCCTTACAGCTACGTCGTATCAATAAGCTATTAATCCTTCAAACCAAAGAAGAATATGAGCAATTATTAGCACAAATTATTGATTTGGAAGATATCCTTGCTCGCAAAGAACGCCGTACCGAGATTATCAAAGAAGAACTCTTGGAAATAAAATCCAAATATGGAGACGAACGTCGTTCTGTCATAGAATATGCAGGGGGTGATATCTCCATTGAGGATATTATCCCTGATGATCAAGTGGTTATTACCATTTCCAACGCAGGTTACATAAAGCGTACTTCTGTCAATGAATACAAAACCCAAGCACGTGGTGGTGTAGGACAAAAAGCCTCTGCTACTCGTGATAAGGACTTCATAGAGCATCTGTTCATAGGTACCAACCACCAGTATATGCTGTTCTTTACAGAGAAAGGTAAGTGTTTTTGGCTCAGGGTGTATGAGATTCCTGAAGGAGGTAAAAATACCAAAGGACGCGCCATACAGAACCTTATCAATATCGAACCCGATGACCTTGTTAAGGCAGTCATCTGTACCCATGACCTCAAGGAAAAAGACTATACCAATAGTCACTATGTCATCATGGCTACTAAAAAAGGGATTATTAAGAAAACCAGCTTAGAACAATATTCACGTCCACGCCAGAATGGTATCGTTGCCATCACTATCAAAGAAGATGATGAGCTATTAGAAGCACGTCTTACCTCTGGCAACAGCCAAATCATGCTAGCTGTCAAGTCTGGAAAGGCTATTCGCTTCCCAGAGGACAAGGTGAGAGCTGTAGGGCGTAGTGGCTCTGGAGTACGAGGTATCTCTTTGGATAGTGACAAAGATGAGGTAATCGGAATGATTGCCATAGAAAATCCTCTGGAAGAAACCGTATTGGTAGTTTCCGAGAATGGTTATGGTAAGCGTACCTTTATCGATGAACCAGAGACAGGAGAAGCAGTATATCGTATTACCAACCGTGGAGGAAAAGGAGTCAAGACTATTTCTATCACAGAGAAAACAGGTAATCTGGTAGCAATCAAGTCAGTTTTGGAAGAAGACGATCTGATGATTATCAATAAGTCGGGTATGGCTATTCGCCTCCCTGTAAGTGGACTCCGTGTGATGGGACGTGCTACCCAAGGAGTACGCCTTATCAATATCAAAGGAAATGACTCTATTGCCGCAGTAGCAAAGGTTATGAAAGAAGATGAGGATGAAAATACTACCGAAGAGATAGAAAACCCAACAGAAGAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Capnocytophaga gingivalis ATCC 33624", "NCBI_taxonomy_id": "553178", "NCBI_taxonomy_cvterm_id": "40642"}, "protein_sequence": {"GI": "EEK14408.1", "sequence": "MVEGEKLIPINIEDQMKTAYIDYSMSVIVSRALPDVRDGLKPVHRRVLFGMHELGVRSNTAHKKSARIVGEVLGKYHPHGDSSVYDTMVRMAQWWNMRYMLVDGQGNFGSIDGDSPAAMRYTEARMRKMAEDMLIDIDKETVDHSLNFDDTLLEPTVLPTRIPNLLVNGSSGIAVGMATNMPPHNLAEVVDGIIAYLGNQDITIDELMEYIKAPDFPTGGIIYGYDGVREAFKTGRGRVVIRAKAHFEEVNGRDCIVVTEVPYQVNPETMREQTSNLVKEGKLEGLADIVDQTGKGGMRIVYELKKDAIPNVVLNNLFKHTALQSSFSVNNIALVNGRPQQLNLKDLIYHFVEHRHDVVYRRTEYELKKAKERIHILEGFMKVMATEDTMGKAIEIIRFHDKPKEDLMTEFELTEIQAEAILALQLRRINKLLILQTKEEYEQLLAQIIDLEDILARKERRTEIIKEELLEIKSKYGDERRSVIEYAGGDISIEDIIPDDQVVITISNAGYIKRTSVNEYKTQARGGVGQKASATRDKDFIEHLFIGTNHQYMLFFTEKGKCFWLRVYEIPEGGKNTKGRAIQNLINIEPDDLVKAVICTHDLKEKDYTNSHYVIMATKKGIIKKTSLEQYSRPRQNGIVAITIKEDDELLEARLTSGNSQIMLAVKSGKAIRFPEDKVRAVGRSGSGVRGISLDSDKDEVIGMIAIENPLEETVLVVSENGYGKRTFIDEPETGEAVYRITNRGGKGVKTISITEKTGNLVAIKSVLEEDDLMIINKSGMAIRLPVSGLRVMGRATQGVRLINIKGNDSIAAVAKVMKEDEDENTTEEIENPTEE"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40641", "model_name": "Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2156": {"model_id": "2156", "ARO_accession": "3003183", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "NDM-14 is a beta-lactamase found in Acinetobacter lwoffii.", "model_sequences": {"sequence": {"3685": {"dna_sequence": {"fmax": "9880", "fmin": "9067", "accession": "KM210086.1", "strand": "+", "sequence": "ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGGCGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAGAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter lwoffii", "NCBI_taxonomy_id": "28090", "NCBI_taxonomy_cvterm_id": "36948"}, "protein_sequence": {"GI": "AJP18054.1", "sequence": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMGALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "NDM-14", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39760", "model_name": "NDM-14", "model_type_id": "40292"}, "2406": {"model_id": "2406", "ARO_accession": "3003930", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4458": "V57L", "4457": "V57M"}, "clinical": {"4458": "V57L", "4457": "V57M"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "rpsJ is a tetracycline resistance protein identified in Neisseria gonorrhoeae. Tetracycline resistance is conferred by binding to the ribosome as a 30S ribosomal protection protein.", "model_sequences": {"sequence": {"3732": {"dna_sequence": {"fmax": "1807670", "fmin": "1807358", "accession": "NC_002946.2", "strand": "-", "sequence": "TTATTGGACTTTAATTTCTACATCAACACCGGCCGGCAAATCCAGCTTCATCAGCGCATCGGTAGTTTTATCGGTCCAATCCACGATGTCCATCAGGCGCAAATGGGTGCGGATTTCCAATTGTTCACGGGAAGTTTTGTTCACGTGCGGAGAACGCAAAATGTTGAAACGCTCGATTTTGGTCGGCAAAGGAATCGGGCCTTTTACAACAGCACCGGTACGTTTTGCAGTTTCAACGATTTCTTGTGCAGAACGGTCAATCAGGGCGTAATCATAAGCTTTCAGGCGGATACGGATTTTTTGGTTTGCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae FA 1090", "NCBI_taxonomy_id": "242231", "NCBI_taxonomy_cvterm_id": "40638"}, "protein_sequence": {"GI": "YP_208874.1", "sequence": "MANQKIRIRLKAYDYALIDRSAQEIVETAKRTGAVVKGPIPLPTKIERFNILRSPHVNKTSREQLEIRTHLRLMDIVDWTDKTTDALMKLDLPAGVDVEIKVQ"}}}}, "ARO_category": {"36324": {"category_aro_name": "antibiotic target protection protein", "category_aro_cvterm_id": "36324", "category_aro_accession": "3000185", "category_aro_description": "These proteins confer antibiotic resistance by bind the antibiotic target to prevent antibiotic binding."}, "36611": {"category_aro_name": "tetracycline resistance gene", "category_aro_cvterm_id": "36611", "category_aro_accession": "3000472", "category_aro_description": "Genes conferring resistance to tetracycline antibiotics."}}, "ARO_name": "rpsJ", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40640", "model_name": "rpsJ", "model_type_id": "40293"}, "2119": {"model_id": "2119", "ARO_accession": "3002489", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "LRA-10 is a beta-lactamase isolated from soil samples in Alaska", "model_sequences": {"sequence": {"3697": {"dna_sequence": {"fmax": "1180", "fmin": "52", "accession": "EU408357.1", "strand": "-", "sequence": "TTACAGTTGTTCCAGGATCGCATGGGCCGCCTTGATACGGTCCGGACCCGGGATGTTCTTGTTCGCGAGGATGACGATGCCGATTTTCTTCTCCGGCACGAACGCCACGTAGGCGCCGAAGCGGCTGGTGGAGCCGGTCTTGTTGAACAGGGTCGCGCCGGACGGTACGCTCGGCGGCGTGAGTTTCTGCGCGGGGTTGGCTTCCCATGCCATGGTGGTGGAGTTGCCGGCCTGTAGCTGCTGCAGGGAGACCGGGTAAGGGTATTGCTCCCAGCCGAGTCCCTGCACCATGCCGCCCACCTTGAAGTAGCCGACATGGGTGCCTTCCACCGCGCGCCGCAACGGCGTTTCCAGCTTGCCCGGGGCGATGTTGGCTTGCACATAGCGGATCATGTCGGCGGCTGTCGACCGGATGCCATAGATTCCGTCGGCGAGGACGCCGGGGTTCATGCGGCCAGGCTTGTTTGCTTGATCGTATCCCCAGGCGTAATTGGCCATGGCGCTTTGTGGCACGTGGACATAGGTGCTCTTCATGCCCATCTGCGTGAGGACATTCGTTTCCAGCGCGTCGGTAAAACGGCTCTTCAGCGCAAGGCTGGTCAGGTGTCCGAACAGCCCGAGGCTGGGATTGGAATAGGTCCGTTGTACGCCGGGCGCGGCCTTCGGTTTCCAGTGCTGGAAGTAGCTGGCCATCTGCTGGTCCGAGACGTCGTCCGGGAATTGCAGCGGCAGTCCGCCCGCCGTGTAGGTGCCCAGATTGAGCAGGGTGGCCTTGTCGATCGCGCTGCCCTTCAGCTGCGGCATGTACTTGCCGGGATGGTCGTCCAGCGACAGCTTGCCGGTCACCTGCGCATACGAGGCCAGCGTGGCGGCAAAAGTCTTGCTGATGGAGCCGAGCTCGAACAGCGTCGCGTCGCTGACGGGCGTGTTGCTCTCGCGCGAGGCGACGCCATAGTTGAAGACGAACGGTTGGCCGTCGACCGTCACGGCGACCGCCATGCCCGGCACGTCGTGTTCGGCCATGACGGGGCGTATCGCCTGGTCGACGATGGCGCGGATCCTGGCGCTGTCGTCGGCGGCCCGGCTGGCGAGCGGCGCGAAACAGGAAGACAGGATGGCGATTGCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "uncultured bacterium BLR10", "NCBI_taxonomy_id": "506513", "NCBI_taxonomy_cvterm_id": "39682"}, "protein_sequence": {"GI": "ACH58999.1", "sequence": "MAIAILSSCFAPLASRAADDSARIRAIVDQAIRPVMAEHDVPGMAVAVTVDGQPFVFNYGVASRESNTPVSDATLFELGSISKTFAATLASYAQVTGKLSLDDHPGKYMPQLKGSAIDKATLLNLGTYTAGGLPLQFPDDVSDQQMASYFQHWKPKAAPGVQRTYSNPSLGLFGHLTSLALKSRFTDALETNVLTQMGMKSTYVHVPQSAMANYAWGYDQANKPGRMNPGVLADGIYGIRSTAADMIRYVQANIAPGKLETPLRRAVEGTHVGYFKVGGMVQGLGWEQYPYPVSLQQLQAGNSTTMAWEANPAQKLTPPSVPSGATLFNKTGSTSRFGAYVAFVPEKKIGIVILANKNIPGPDRIKAAHAILEQL"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "LRA-10", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "38889", "model_name": "LRA-10", "model_type_id": "40292"}, "2383": {"model_id": "2383", "ARO_accession": "3003905", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Kanamycin nucleotidyltransferase sequence from Staphylococcus aureus plasmid. Confers resistance to kanamycin, neomycin and other aminoglycosides", "model_sequences": {"sequence": {"3702": {"dna_sequence": {"fmax": "27499", "fmin": "26737", "accession": "NC_013342.1", "strand": "-", "sequence": "TCAAAATGGTATGCGTTTTGACACATCCACTATATATCCGTGTCGTTCTGTCCACTCCTGAATCCCATTCCAGAAATTCTCTAGCGATTCCAGAAGTTTCTCAGAGTCGGAAAGTTGACCAGACATTACGAACTGGCACAGATGGTCATAACCTGAAGGAAGATCTGATTGCTTAACTGCTTCAGTTAAGACCGAAGCGCTCGTCGTATAACAGATGCGATGATGCAGACCAATCAACATGGCACCTGCCATTGCTACCTGTACAGTCAAGGATGGTAGAAATGTTGTCGGTCCTTGCACACGAATATTACGCCATTTGCCTGCATATTCAAACAGCTCTTCTACGATAAGGGCACAAATCGCATCGTGGAACGTTTGGGCTTCTACCGATTTAGCAGTTTGATACACTTTCTCTAAGTATCCACCTGAATCATAAATCGGCAAAATAGAGAAAAATTGACCATGTGTAAGCGGCCAATCTGATTCCACCTGAGATGCATAATCTAGTAGAATCTCTTCGCTATCAAAATTCACTTCCACCTTCCACTCACCGGTTGTCCATTCATGGCTGAACTCTGCTTCCTCTGTTGACATGACACACATCATCTCAATATCCGAATAGGGCCCATCAGTCTGACGACCAAGAGAGCCATAAACACCAATAGCCTTAACATCATCCCCATATTTATCCAATATTCGTTCCTTAATTTCATGAACAATCTTCATTCTTTCTTCTCTAGTCATTATTATTGGTCCATTCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"GI": "YP_006938491.1", "sequence": "MNGPIIMTREERMKIVHEIKERILDKYGDDVKAIGVYGSLGRQTDGPYSDIEMMCVMSTEEAEFSHEWTTGEWKVEVNFDSEEILLDYASQVESDWPLTHGQFFSILPIYDSGGYLEKVYQTAKSVEAQTFHDAICALIVEELFEYAGKWRNIRVQGPTTFLPSLTVQVAMAGAMLIGLHHRICYTTSASVLTEAVKQSDLPSGYDHLCQFVMSGQLSDSEKLLESLENFWNGIQEWTERHGYIVDVSKRIPF"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}}, "ARO_name": "ANT(4')-Ib", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40608", "model_name": "ANT(4')-Ib", "model_type_id": "40292"}, "2404": {"model_id": "2404", "ARO_accession": "3003928", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4449": "S91F", "4451": "D95N", "4450": "D95G"}, "clinical": {"4449": "S91F", "4451": "D95N", "4450": "D95G"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutation in Neisseria gonorrhoeae DNA gyrase subunit A. Decreases affinity between fluoroquinolone antibiotic molecule and gyrA, thereby conferring resistance to fluoroquinolone", "model_sequences": {"sequence": {"3730": {"dna_sequence": {"fmax": "621189", "fmin": "618438", "accession": "NC_002946.2", "strand": "-", "sequence": "TCAGTTCTCGGCTTCCGGTTCGGTTACATTGGAAATTACAGAAGCGCCGGAGAGTTCGGATTCGTCTTCGGCAACACGTTCCAGCGATACCAAGGTTTCGCCTTCGTCCAAGTTAATCAGTTTCACGCCTGCTGCGGCGCGGCCGGTTTCGCGGATTTGTTCGACTTTGGTACGGATAAGCACGCCGCCGCTGGTAATCAGCATCAAATCGTCGGTTTCGCCGACCAAGGTTGCGGCGACCAAATCGCCGTTGCGCTCGCCGGTGTTAATGGCAATACTGCCTTGCCCGCCTTTGTTTTTGCGGCTGTAATCGGCAATCGGGGTGCGTTTTCCGTATCCGTTGGCGGTGGCGGTTAAAACTTGCAAACCGCTTTCTTCGGTTTCAGGGGCGAAGGTAATCAGGCTGACGATTTTGCCGTCGGCAGGCAGGCGCATACCGCGCAAACCGCCGCTGCCGCGACCGGACGGACGCACGCCGTTTTTGCCGCTTGGCAGGGTGTTTTCGTTGTCGGCGGTTTCGTCTTCGAGGTCGTCTGAAATCTCGGTTTCGATGTCGGCATCTTCCGCTTCGTCGTTGCCGGATTTTTCCCAGTATTCGTTGAAGCGGATGGCTTTGCCCAAGTTGGAGAACAACATAATGTCGTCCGCACCGCCTGTTTGCGCAGCGCCGACGAGGTAGTCGCCTTCTTTGAGTGCGATGGCTTTAATGCCTTGGGCGCGGACGTTTTTAAAGGCGGAAAGTTGGACTTTTTTCACCATTCCCTGCGCGGTGGCGAAGAAGACGTATTGGTCTTCGGGAAACTCGCGTACTGCCAGAATCGCGCTGACTTTTTCGCCTTCTTCCAGCTGGATGACGTTGTTAATCGGACGGCCGCGGCTGTTGCGTCCGCCTTCGGGCAGTTTGTAAACCTTAATCCAGTGGCACTTGCCGAGGTTGGTAAAACACATCAAATAGTCATGCGTGTTGGCAACAAACAGGGTTTCGATAAAGTCTTCGTCTTTGGTGGCAGCCGCCTGTTTGCCGCGCCCGCCGCGACGCTGAGCCTGATAGTCGGTGGTCGGCTGGGTTTTTATATAGCCGCCGTGGGTCAGGGTCACGACCATTTCGCGTTGCGGAATCAGGTCTTCATCGGCAATGTCGCCGCCGAACGGGTTGATTTCGCTGCGGCGTTCGTCGCCATAGTTGGTTTTGATTTCTTCCAGTTCGTCACGGATGATTTGGGTAATGCGTTCGGGTTTGGAGAGGATATCCACAAAGTCGATGATTTTACCCATCAGGTTTTTGTAGCTTTCGATAATTTCTTTCTGATCGAGGCCGGTCAGGTTTCGCAGGCTCATGCGTAAAATAGCATCTGCCTGAATCTCGCTCAGGTAATAACCTTGTTTTTTCAGACCAATGTTTGCAGCCAATCCTTCCGGACGCATCATTTCCAAATCCAGACCGGAACGCGTCAGCATTTCTTCAACGAGGCTGCTGCGCCAAGGGCGCGCAAGCAGTTTTTCTTTGGCCTCGGCCGCGTTGGGCGATTCTTTGATGAGCTTGATGATTTCATCGATATTGGACAGTGCGACGGCTTTGCCTTCGGCGATATGCCCTTCATGGCGTGCCTTCTTCAGCCGGAAAAGCGTACGTCGGGTAACGACTTCGCGGCGGTGGCGCAGGAATTCGGAGAGAATCTGTTTCAGGTTTAACAGGCGCGGTTGTCCGTCGACCAAAACAACCATATTGATGCCGAAACTGTCTTGCAGCGGAGTCAGTTTGTAGAGTTGGTTTAAGACGACTTCGGCATTTTCGTTGCGTTTCAGCTCGATAACGACGCGCATCCCGGATTTGTCGGATTCGTCGCGGAGCTCGGAAATGCCTTCCAGCGTTTTTTCCCGAACCAAATCGCCGATTTTCTCGACCAACTTGGCTTTGTTGACCTGATAGGGGATTTCGTCGATAACGATGGCTTCGCGTTCGCCGTTTTTGCCTATGGGTTCGATATGGGTCTTACCGCGTATAACGACGCGGCCGCGGCCTGTTTTATAGCCTTCGCGCACGCCGCCCAAGCCGTAGATGGTTGCCCCGGTCGGGAAGTCGGGGGCTTGGATAATGTCGATCAGTTCGTCGATTTCGGTTTTGGGTTCGTCCAAAAGACGCAGACAGGCGTTGATGGTGTCGGTGAGGTTGTGCGGCGGGATGTTGGTCGCCATACCGACGGCGATACCGGACGAGCCGTTGACGAGCAGTGTGGGGAAACGGGTCGGCAGTACAAGCGGCTCGTGTTCGCTACCGTCGTAGTTCGGGCCGAAATTAACGGTTTCTTCCTCAATGTCTGCCAGCATTTCATGTGAGATTTTCGCCATGCGGATTTCGGTATAGCGCATGGCTGCGGCGGCAAGCCCGTCCACCGATCCGAAGTTGCCCTGTCCGTCTATCAGCACATAACGCATAGCGAAATTTTGCGCCATACGGACGATGGTGTCGTAAACTGCGGAATCGCCGTGGGGGTGGTATTTACCGATGACGTCGCCGACGATGCGCGCCGATTTTTTGTAGGCGGCATTCCAGTTATTTTTCAGCTCGTGCATCGCGTACAGTACGCGCCGGTGCACCGGCTTTAGGCCGTCGCGAACGTCCGGCAGCGCGCGCCCGACAATGACGCTCATGGCGTAGTCGAGATAGCTTTTGCGCATTTCGTCTTCAAGGCTGACGGGCAGGGTTTCGAGGGCGAATTTGTGGTCGTGGCGGATGGTTGCGTCGGTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae FA 1090", "NCBI_taxonomy_id": "242231", "NCBI_taxonomy_cvterm_id": "40638"}, "protein_sequence": {"GI": "YP_207769.1", "sequence": "MTDATIRHDHKFALETLPVSLEDEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELKNNWNAAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQNFAMRYVLIDGQGNFGSVDGLAAAAMRYTEIRMAKISHEMLADIEEETVNFGPNYDGSEHEPLVLPTRFPTLLVNGSSGIAVGMATNIPPHNLTDTINACLRLLDEPKTEIDELIDIIQAPDFPTGATIYGLGGVREGYKTGRGRVVIRGKTHIEPIGKNGEREAIVIDEIPYQVNKAKLVEKIGDLVREKTLEGISELRDESDKSGMRVVIELKRNENAEVVLNQLYKLTPLQDSFGINMVVLVDGQPRLLNLKQILSEFLRHRREVVTRRTLFRLKKARHEGHIAEGKAVALSNIDEIIKLIKESPNAAEAKEKLLARPWRSSLVEEMLTRSGLDLEMMRPEGLAANIGLKKQGYYLSEIQADAILRMSLRNLTGLDQKEIIESYKNLMGKIIDFVDILSKPERITQIIRDELEEIKTNYGDERRSEINPFGGDIADEDLIPQREMVVTLTHGGYIKTQPTTDYQAQRRGGRGKQAAATKDEDFIETLFVANTHDYLMCFTNLGKCHWIKVYKLPEGGRNSRGRPINNVIQLEEGEKVSAILAVREFPEDQYVFFATAQGMVKKVQLSAFKNVRAQGIKAIALKEGDYLVGAAQTGGADDIMLFSNLGKAIRFNEYWEKSGNDEAEDADIETEISDDLEDETADNENTLPSGKNGVRPSGRGSGGLRGMRLPADGKIVSLITFAPETEESGLQVLTATANGYGKRTPIADYSRKNKGGQGSIAINTGERNGDLVAATLVGETDDLMLITSGGVLIRTKVEQIRETGRAAAGVKLINLDEGETLVSLERVAEDESELSGASVISNVTEPEAEN"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Neisseria gonorrhoeae gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40637", "model_name": "Neisseria gonorrhoeae gyrA conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2402": {"model_id": "2402", "ARO_accession": "3003925", "model_param": {"blastp_evalue": {"param_value": "1e-145", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4440": "S84F"}, "clinical": {"4440": "S84F"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutation of Haemophilus parainfluenzae parC resulted in the lowered affinity between fluoroquinolones and ParC. Thus, conferring resistance.", "model_sequences": {"sequence": {"3728": {"dna_sequence": {"fmax": "1907418", "fmin": "1905162", "accession": "NC_015964.1", "strand": "+", "sequence": "ATGAGCAATATTAATTACGAAGGCATCGAGCAGATGCCACTTCGCACCTTTACAGAAAAGGCTTACCTTAATTATTCAATGTACGTCATCATGGATCGTGCATTGCCTTTTATTGGCGATGGCTTAAAGCCTGTTCAACGTCGTATTGTCTATGCGATGTCTGAACTGGGTTTAAATGCCGCGGCAAAATTTAAAAAGTCCGCGCGTACCGTCGGTGATGTGTTAGGTAAATTCCATCCACATGGTGACTCTGCTTGTTATGAAGCCATGGTATTAATGGCTCAGCCTTTTTCTTATCGTTATCCTTTGGTAGATGGGCAAGGAAACTGGGGGGCGCCAGATGATCCTAAATCATTTGCGGCAATGCGTTATACAGAATCTCGCCTGTCCAAAATCTCTGAAATTTTATTATCTGAATTAGGCCAAGGCACTGTTGATTTCCAACCGAACTTTGATGGTACCTTAGAAGAACCTCAATATTTGCCTGCACGTTTGCCTCATATTCTGTTAAACGGCACCACCGGGATTGCCGTCGGGATGGCAACCGATATTCCACCACATAATATTAATGAAGTGGCGGATGCCGCTGTTATGCTATTAGATAATCCAAAAGCAGGATTAGATGATGTACTCAATATCATTCAAGGCCCGGATTTCCCAACTGAAGCGGAAATTATTTCACCAAAAGATGATATTCGCAAAATGTATGAAACCGGTCGTGGTTCTATCAAAATGCGTGCAACATGGCATAAAGAAGACGGTGAAATCATCATTAGTGCACTTCCTCATCAATCTTCACCATCAAAAATCATTGCGCAAATTGCTGAACAAATGACAGCAAAAAAATTGCCAATGGTGGAAGATATTCGTGATGAAGCAGATTATGAAAACCCTGTACGTATCGTGCTTGTGCCACGTTCAAATCGTGTTGATACGGATGCCTTAATGGCGCATTTATTTGCGACGACTGATCTCGAAAAAAGCTATCGTGTAAATATGAATATGATCGGACTTGATCATAAACCAGCCGTAAAAGGCCTACTTCAAGTTCTTATCGAATGGCTGACATTCCGTCGTACTACCGTGACACGTCGTTTACAACATCGTTTAGATAAAGTACTCGCTCGTTTGCACATTTTAGATGGTTTGATGATTGCCTTCCTCAATATTGACGAAGTGATTGAGATTATTCGTACTGAAGATGAACCAAAACAAGTTTTAATGGCTCGCTTTAACTTAAGTGATGAACAGGCAGAAGCCATTTTAAACTTACGTTTACGCCATTTGGCCAAATTAGAAGAACATCAATTACAAGCTGAAAAAGATAAACTCGAAGAAGAGCGGTCAAATTTAGAGTTAATTTTAGGATCTGAACGTCGCTTAAATACCTTGATCAAAAAAGAAATTCAAGAAGATGCGAAAAAATACGCCAGCCCTAGAATGTCTCAATTAGTTGAACGTGAAGAAGCGAAAGCCATTTCTGAAAGTGAAATGACTCCGGCTGAACCCGTTACCGTTATCTTATCTGAAATGGGCTGGGTACGCTGTGCAAAAGGTCATGACATTGATCCGGAAGGATTAAGCTATAAAGCAGGCGATAAATATCTGGCTCACGCTTGCGGTAAAAGTAATCAGCCTGTAATCTTTATTGACAGCACGGGGCGTAGCTATGCTTTAGATCCATTAAGCTTGCCTTCTGCGCGTTCACAAGGTGAACCACTCACCGGTAAACTGACATTACCGGCCGGTGCGACCATTGAACAGGTTATTATGGAACCTGAAAAACAAGAATTATTGATGGCATCAGATGCAGGATATGGTTTTATTTGCAAATTTGAAGATTTAATTGCGCGTAATAAAGCAGGAAAAGCCTTGATTTCTTTGCCAGAAAATGCGAAAGTCTTGAAACCTGAGACACTTTCCGAGTCGACCTCACTTCTTGTGTCCCTCACTTCAGCGGGTCGAATGCTGATTTTTCCGGTACGGGATTTACCGGCATTATCAAAAGGGAAAGGCAACAAAATCATCAGTATTCCAGCAGCGAATGCAAAAGCGCGGTCAGAATTATTAGTGAAATTGTTCTTAATTTCAGAGCAAGCTAGCCTTGAGTTCCATTCCGGTAAACGAAAAATCACATTAAAACCGGAAGATCTGCAAAAATTCCGAGCGGAACGCGGCAGAAAAGGCTCCCAATTACCACGTGGATTACATAGCAATGTTGATATTGTGGTAGTTGAACCCGAACACAACTCATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Haemophilus parainfluenzae", "NCBI_taxonomy_id": "729", "NCBI_taxonomy_cvterm_id": "36927"}, "protein_sequence": {"GI": "WP_041918279.1", "sequence": "MSNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNAAAKFKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKISEILLSELGQGTVDFQPNFDGTLEEPQYLPARLPHILLNGTTGIAVGMATDIPPHNINEVADAAVMLLDNPKAGLDDVLNIIQGPDFPTEAEIISPKDDIRKMYETGRGSIKMRATWHKEDGEIIISALPHQSSPSKIIAQIAEQMTAKKLPMVEDIRDEADYENPVRIVLVPRSNRVDTDALMAHLFATTDLEKSYRVNMNMIGLDHKPAVKGLLQVLIEWLTFRRTTVTRRLQHRLDKVLARLHILDGLMIAFLNIDEVIEIIRTEDEPKQVLMARFNLSDEQAEAILNLRLRHLAKLEEHQLQAEKDKLEEERSNLELILGSERRLNTLIKKEIQEDAKKYASPRMSQLVEREEAKAISESEMTPAEPVTVILSEMGWVRCAKGHDIDPEGLSYKAGDKYLAHACGKSNQPVIFIDSTGRSYALDPLSLPSARSQGEPLTGKLTLPAGATIEQVIMEPEKQELLMASDAGYGFICKFEDLIARNKAGKALISLPENAKVLKPETLSESTSLLVSLTSAGRMLIFPVRDLPALSKGKGNKIISIPAANAKARSELLVKLFLISEQASLEFHSGKRKITLKPEDLQKFRAERGRKGSQLPRGLHSNVDIVVVEPEHNS"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40634", "model_name": "Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2403": {"model_id": "2403", "ARO_accession": "3003926", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4443": "S97P", "4444": "S83F", "4445": "D87N", "4446": "D87Y"}, "clinical": {"4443": "S97P", "4444": "S83F", "4445": "D87N", "4446": "D87Y"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid, a fluoroquinolone antibiotic.", "model_sequences": {"sequence": {"3729": {"dna_sequence": {"fmax": "2376347", "fmin": "2373710", "accession": "NC_003197.1", "strand": "-", "sequence": "TTACTCGTCAGCGTCATCCGCAACGTCGTCATCGCTTTCCGCTTCCGGGGCGATATCCTCATCCCCTTCCGCCACGCTGCCGTCGATAGCGTCGAGTTCTTCGTCATCTACCGGTTCAGCAACGCGTTGCAGACCCACCACGTTTTCATCTTCCGCCGTGCGGATAAGGATAACGCCCTGGGTATTACGTCCCACTACGCTGATCTCGGACACACGGGTACGCACCAGAGTACCGGCATCCGTGATCATCATGATCTGGTCGCAATCGTCTACCTGTACCGCACCGACAACGGAACCGTTGCGCTCGGTCACTTTGATAGAGATAACGCCCTGCGTCGCACGAGACTTGGTCGGGTACTCGTCCGCTGCGGTACGCTTCCCGTAGCCGTTTTGCGTTACGGTCAGAATAGCGCCTTCGCCGCGTGGGATGATCAGAGAGACGACTTTATCGTCTCCCGCCAGCTTAATACCGCGCACACCGGTCGCGGTACGCCCCATCGCACGGACGGCGTCTTCTTTGAAGCGCACCACTTTACCCGCGGCCGAGAACAGCATGACTTCGTCAGAACCAGAAGTCAGGTCAACGCCAATCAGCTCGTCGCCGTCGTTGAGGTTCACCGCGATAATACCGGCGGAACGCGGACGGCTGAATTCGGTCAGCGCCGTTTTCTTCACGGTACCGCTGGCGGTCGCCATAAAGACGTTGACGCCTTCTTCATACTCACGAACCGGCAGAATCGCGGTGATACGTTCGTTGGCTTCCAGCGGCAGCAGGTTGACGATCGGACGACCGCGCGCGCCGCGGCTGGCTTCCGGCAGCTGATAGACCTTCATCCAGTACAGACGGCCCCGGCTGGAGAAGCAGAGGATGGTGTCATGGGTGTTAGCCACCAGCAGGCGGTCGATAAAGTCTTCTTCTTTAATACGCGCGGCAGATTTACCTTTCCCACCACGACGTTGCGCTTCGTAATCTGTCAGCGGTTGATATTTGACGTAACCCTGGTGAGACAGCGTCACGACAACATCTTCCTGGCTAATCAGATCTTCGATATTAATATCGGCGCTGTTGGCGGTGATTTCGGTACGACGCTCATCGCCGAACTGATCGCGAATTAACTCCATCTCTTCGCGGATCACTTCCATCAGGCGATCGGCGCTGCCCAGAATGTGCAGCAATTCAGCAATCTGCTCCAGCAGCTCTTTGTATTCGTCGAGCAGTTTTTCATGCTCCAGGCCGGTCAGTTTCTGCAAACGCAGATCCAGAATCGCCTGCGCCTGCTGTTCAGTCAGGTAGTACTGACCGTCACGCACGCCAAATTCTGGCTCCAGCCATTCCGGACGCGCGGCGTCATCACCAGCGCGCTCCAGCATCGCAGCAACGTTGCCCAGATCCCACGGACGCGAAATCAGCGCCGCTTTTGCTTCCGCCGGCGTTGGCGCGCGGCGAATCAGTTCGATAATCGGGTCGATGTTGGCCAGCGCAATCGCCAGAGCTTCAAGGATATGCGCACGGTCACGGGCTTTACGCAGTTCAAAAATAGTCCGACGCGTCACCACTTCACGGCGGTGGCGCACGAACGCTGAAATGATATCTTTCAGGTTCATGATCTTCGGCTGGCCGTGATGCAGCGCCACCATGTTAATACCGAAGGAAACCTGTAGCTGGGTCTGGGAGTAGAGATTATTAAGCACCACCTCGCCCACCGCATCGCGTTTCACTTCAATCACGATGCGCATCCCGTCTTTGTCGGATTCGTCACGCAGCGCGCTGATGCCTTCCACGCGTTTATCTTTCACCAGCTCGGCGATTTTCTCGATCAGGCGCGCTTTGTTCACCTGATAGGGAATTTCATGGACGATGATGGTTTCACGGCCCGTTTTGGCGTCAGCTTCAACTTCCGCGCGGGCGCGAATGTACACTTTGCCACGACCGGTGCGGTAGGCTTCTTCGATACCACGACGACCGTTGATGATCGCGGCGGTCGGGAAGTCCGGCCCCGGAATATGTTCCATCAGCCCTTCAATGCTGATGTCTTCGTTGTCGATATACGCCAGGCAGCCGTTAATCACTTCCGTCAGGTTGTGCGGCGGGATATTCGTCGCCATACCTACTGCGATACCGGAAGAACCGTTCACCAGCAGATTCGGAATTTTGGTCGGCATGACGTCCGGAATTTTTTCCGTACCGTCATAGTTATCCACGAAATCCACCGTCTCTTTTTCGAGATCGGCCATCAGTTCGTGGGCGATTTTCGCCAGACGGATCTCCGTATAACGCATTGCCGCCGCGGAGTCGCCGTCAATAGAACCGAAGTTACCCTGACCATCCACCAGCATGTAACGCAGCGAGAATGGCTGCGCCATACGAACGATGGTGTCATACACTGCGGAATCGCCGTGGGGATGGTATTTACCGATTACGTCACCAACGACACGGGCAGATTTTTTATAGGCTTTGTTCCAGTCATTGCCCAATACGTTCATGGCGTAAAGTACGCGACGGTGTACCGGCTTCAGGCCATCTCGGACATCCGGCAGCGCACGGCCAACAATGACCGACATCGCATAATCCAGATAGGAGCTCTTCAGCTCCTCCTCAATGTTGACCGGTGTAATTTCTCTCGCAAGGTCGCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Typhimurium str. LT2", "NCBI_taxonomy_id": "99287", "NCBI_taxonomy_cvterm_id": "35734"}, "protein_sequence": {"GI": "NP_461214.1", "sequence": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Salmonella enterica gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40635", "model_name": "Salmonella enterica gyrA conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2400": {"model_id": "2400", "ARO_accession": "3003923", "model_param": {"blastp_evalue": {"param_value": "1e-170", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "RND efflux pump conferring resistance to fluoroquinolone", "model_sequences": {"sequence": {"3726": {"dna_sequence": {"fmax": "51003", "fmin": "47850", "accession": "NC_010378.1", "strand": "+", "sequence": "ATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATTTTAATTTTTATCACCGGGTTAATCGCTATCCCACTGCTGCCGGTGAGCGAATATCCGGATGTCGTCCCGCCGAGCGTCCAGGTGCGCGCGGAGTATCCCGGCGCCAACCCGAAAGTGATTGCCGAGACCGTGGCGACGCCGCTGGAGGAAGCGATCAACGGCGTTGAAAACATGATGTACATGAAATCGGTCGCCGGCTCCGACGGCGTGCTGGTCACCACCGTCACCTTCCGCCCGGGTACCGACCCGGATCAGGCGCAGGTTCAGGTGCAGAACCGCGTCGCGCAGGCCGAAGCGCGTCTGCCGGAGGATGTACGCCGTCTGGGGATCACCACCCAGAAGCAGTCTCCGACGCTGACCCTGGTGGTGCATCTGTTCTCCCCCGGCGGGAAGTACGACTCGCTGTATATGCGCAACTACGCCACGCTGAAAGTGAAGGATGAGCTGGCGCGCCTGCCCGGCGTCGGCCAGATCCAGATTTTTGGCTCCGGTGAATATGCGATGCGCGTCTGGCTGGATCCCAATAAGGTCGCTGCCCGCGGTCTGACGGCCTCGGATGTGGTGACGGCGATGCAGGAGCAAAACGTCCAGGTGTCTGCCGGACAGCTTGGCGCCGAGCCGCTGCCGCAGGAGAGCGATTTCCTGATCTCCATTAACGCCCAGGGCCGTCTGCATACCGAAGAAGAGTTTGGCAATATCATTCTGAAAACGGCGCAGGATGGCTCGCTGGTCCGCCTGCGCGACGTGGCGCGCATCGAGATGGGTTCCGGTAGCTATGCGCTGCGCTCCCAGCTCAACAATAAGGATGCGGTCGGGATCGGTATCTTCCAGTCACCCGGCGCTAACGCCATCGATCTGTCGAACGCGGTACGCGCCAAAATGGCCGAGCTGGCCACCCGCTTCCCGGAAGATATGCAATGGGCGGCGCCGTACGACCCGACGGTTTTCGTCCGCGACTCCATCCGCGCGGTGGTGCAGACGCTGCTGGAGGCGGTAGTGCTGGTGGTGCTGGTAGTGATCCTGTTCCTGCAGACCTGGCGCGCGTCGATTATCCCGTTGATCGCTGTGCCGGTATCGGTGGTGGGTACCTTCAGCATTCTCTATCTGCTGGGCTTCTCGCTGAATACCCTGAGCCTGTTCGGGCTGGTACTGGCTATCGGTATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGTAATATCGAAGAGGGGCTTGCGCCGCTTGCCGCGGCGCATCAGGCGATGCGTGAGGTCTCCGGGCCGATTATCGCCATTGCGCTGGTGCTGTGTGCGGTGTTCGTGCCGATGGCGTTTCTCTCCGGGGTCACCGGCCAGTTCTACAAACAGTTCGCGGTGACCATCGCCATCTCGACGGTGATCTCGGCCATCAACTCGCTGACGCTCTCCCCGGCGCTGGCGGCCCTGCTGTTAAAGCCGCACGGCGCGAAGAAAGACCTCCCTACCCGGCTGATCGATCGCCTGTTTGGCTGGATTTTCCGTCCGTTTAACCGCTTTTTCCTGCGCAGCTCGAACGGCTATCAGGGACTGGTAGGCAAAACGCTTGGACGCCGTGGCGCAGTGTTTGCGGTGTACCTGCTGCTGCTCTGCGCCGCTGGGGTGATGTTTAAAGTCGTCCCCGGCGGGTTTATTCCCACCCAGGATAAGCTGTATCTCATTGGCGGCGTGAAGATGCCGGAAGGGTCGTCGCTGGCGCGCACCGACGCGGTGATCCGCAAAATGAGCGAGATCGGGATGAATACCGAAGGGGTCGACTATGCGGTCGCTTTCCCGGGGCTTAACGCGCTGCAGTTCACCAACACGCCGAATACCGGGACGGTCTTTTTTGGCCTGAAACCGTTCGACCAGCGCAAACACACGGCGGCGGAAATTAACGCGGAGATCAACGCCAAAATCGCGCAAATCCAGCAGGGCTTTGGCTTTTCCATCCTGCCGCCGCCGATTTTAGGTCTGGGTCAGGGTTCCGGCTACTCCCTGTACATCCAGGATCGCGGAGGGCTGGGCTATGGCGCGCTGCAAAGCGCGGTGAATGCGATGTCCGGGGCGATTATGCAGACGCCGGGGATGCACTTCCCGATCTCGACTTACCAGGCTAACGTGCCGCAGCTGGACGTGCAGGTCGATCGCGATAAGGCGAAAGCGCAGGGGGTATCGCTAACCGATCTGTTCGGTACGCTGCAGACCTATCTCGGCTCGTCTTATGTCAATGACTTTAACCAGTTCGGGCGTACCTGGCGCGTGATGGCCCAGGCTGACGGACCATACCGCGAGAGCGTGGAAGATATCGCCAATCTGCGCACCCGCAATAATCAGGGCGAAATGGTACCGATCGGCAGTATGGTGAATATCAGTACCACCTACGGGCCGGATCCGGTGATCCGCTACAACGGTTATCCGGCGGCGGACCTGATTGGCGATGCCGATCCGCGGGTCCTCTCTTCTTCGCAGGCGATGACGCATCTGGAAGAGCTGTCGAAGCAGATCCTGCCGAATGGGATGAATATTGAGTGGACGGATCTCAGCTTCCAGCAGGCCACCCAGGGCAACACGGCGCTGATCGTCTTCCCGGTGGCGGTGCTGCTGGCATTCCTCGTACTGGCCGCGCTGTATGAAAGCTGGACCCTGCCGCTGGCGGTGATCCTTATCGTACCGATGACGATGCTCTCCGCGCTGTTTGGCGTCTGGCTGACCGGGGGCGATAACAACGTCTTCGTGCAGGTGGGTCTGGTGGTCCTGATGGGCCTGGCCTGTAAAAACGCCATTCTGATCGTCGAGTTTGCCCGCGAGCTGGAGATCCAGGGGAAAGGCATCATGGAAGCGGCGCTGGAGGCATGCCGCCTGCGTCTGCGCCCGATCGTGATGACCTCCATCGCCTTTATCGCCGGGACCATTCCGCTGATCCTCGGCCACGGCGCGGGGGCGGAAGTCCGCGGCGTCACCGGGATCACGGTGTTCTCCGGGATGCTGGGCGTGACGCTCTTCGGTCTGTTCCTGACGCCGGTGTTTTACGTGACGCTACGGAAACTGGTGACCCGCAGGAAGCCGGTCCAGGAGGATCTGCCCGCCTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"GI": "YP_001693238", "sequence": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPGGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVGKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTDLFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPYRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLPA"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "oqxB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40632", "model_name": "oqxB", "model_type_id": "40292"}, "2386": {"model_id": "2386", "ARO_accession": "3003907", "model_param": {"blastp_evalue": {"param_value": "1e-160", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Cfr-like methyltransferase enzyme conferring resistance to multiple clinically relevant antibiotic classes.", "model_sequences": {"sequence": {"3704": {"dna_sequence": {"fmax": "3932167", "fmin": "3931126", "accession": "NC_013406.1", "strand": "-", "sequence": "TTAAATGTTACCGTTTGATCCATATAGTTGACCGCATGCTGCGTTGATGTCTGATCCGAATTGGGTCCTCACGGTGACATGGATTCCCTTTGACTTCAAGATTCTAAGGAACATATTGATGCTGTTCTGATCCGACTCTACAAAACTTTGTGATGTGGCATCAGTGGAATTGTATGGAATTAGATTGACGTGATATAAATGTTCCCACGACCCTCTTTCACGCAACAAATCAGCAACGGCTTTAGCATGTTTAGTTGAATCGTTGATACCCCTTAGCAGGATATAAGCAATGTAAACCTTTCGCTTTGTTTGCTGAATATGCTCGTCCAACACGGTCATAACTTCTTCTAATGGAAAATGATTGTTAATGGGCATTAACTCGCTTCTCTGATCATGAAATGGTGAATGAAGCGAGAACGTTAAATTAATCTGTGGAAATTCCTTCGTCAACTTTTTTACTCCAGGTAATAAACCTATGGTAGAAACCGTAATCCTTCGATGTCCTAAACCGAAAAGTTTAGGATCCGTCAGCAAATGCAAAGCATCAAATACATATGGATTTGCAAGTGCCTCTCCCATTCCCATAAAAGACACACTGTCCAAGGGATGGTTATTCAAAGTAAAATAAAGCAGTTGATCCGTTATTTCATCCGTTGTAAGATTCCTCTTCAAACCGAGTGTTCCCGTAGCGCAAAATGTACAACCAAATCCGCAACCGCACTGCGAAGAGATACAATAGGATTCCCAGCCCGTTTGATAACTTAACCTTACGGATTCAATGTATTCATCGCCTGGGATAGCAAACAGAATTTTGCTAACTTGGTTGGATTTCTGCTCCATTTTCGGTGTGATGCTTAACACATTGTTTCCAAGCTCTTTGATTAATTCATTTCTTACAGGCTTAGGCAAGTTGTTCATTGCTTCGAAATTTCCGATCTTGTTCTTGAAGATTGCCTCTGTTATTTGCGAATATCTATAATTCGGTTGATTTAGAGCCGATAAGATCTTACGTATTTTTTCATACTTAGATAAATACTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. Y412MC10", "NCBI_taxonomy_id": "481743", "NCBI_taxonomy_cvterm_id": "40613"}, "protein_sequence": {"GI": "WP_015735625.1", "sequence": "MKYLSKYEKIRKILSALNQPNYRYSQITEAIFKNKIGNFEAMNNLPKPVRNELIKELGNNVLSITPKMEQKSNQVSKILFAIPGDEYIESVRLSYQTGWESYCISSQCGCGFGCTFCATGTLGLKRNLTTDEITDQLLYFTLNNHPLDSVSFMGMGEALANPYVFDALHLLTDPKLFGLGHRRITVSTIGLLPGVKKLTKEFPQINLTFSLHSPFHDQRSELMPINNHFPLEEVMTVLDEHIQQTKRKVYIAYILLRGINDSTKHAKAVADLLRERGSWEHLYHVNLIPYNSTDATSQSFVESDQNSINMFLRILKSKGIHVTVRTQFGSDINAACGQLYGSNGNI"}}}}, "ARO_category": {"36406": {"category_aro_name": "linezolid resistance gene", "category_aro_cvterm_id": "36406", "category_aro_accession": "3000267", "category_aro_description": "Genes conferring resistance to linezolids."}, "36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}, "36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}, "36191": {"category_aro_name": "phenicol resistance gene", "category_aro_cvterm_id": "36191", "category_aro_accession": "3000052", "category_aro_description": "Genes conferring resistance to phenicol antibiotics."}, "36380": {"category_aro_name": "lincosamide resistance gene", "category_aro_cvterm_id": "36380", "category_aro_accession": "3000241", "category_aro_description": "Genes conferring resistance to lincosamides."}, "36379": {"category_aro_name": "streptogramin resistance gene", "category_aro_cvterm_id": "36379", "category_aro_accession": "3000240", "category_aro_description": "Genes conferring resistance to streptogramin antibiotics."}}, "ARO_name": "CIPa", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40612", "model_name": "CIPa", "model_type_id": "40292"}, "2110": {"model_id": "2110", "ARO_accession": "3003150", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "CARB-20 is a beta-lactamase found worldwide in Vibrio parahaemolyticus", "model_sequences": {"sequence": {"3694": {"dna_sequence": {"fmax": "1052", "fmin": "0", "accession": "NG_048723.1", "strand": "+", "sequence": "ATCGACAGGGATTTAACAGTGGTTAGAGTATTCACTCGTTATAGTTTGCTTAACATCGCCAAAGTGCGAATCAAAACCAAAAGAATGAAGAACACCACGCATGAAAAAGTTATTCCTGTTGGTTGGGCTGATGGTTTGCTCAACTGTTAGTTACGCCTCCAAATTAAACGAAGACATCTCCCTCATCGAGAAACAAACATCTGGGCGAATTGGAGTGTCAGTCTGGGATACACAAACGGACGAGCGTTGGGATTATCGCGGAGACGAACGTTTCCCATTAATGAGCACATTCAAAACGTTAGCGTGTGCCACCATGCTAAGCGACATGGACAGCGGCAAACTCAACAAAAATGCCACAGCGAGAATCGATGAACGCAATATTGTGGTTTGGTCTCCGGTGATGGATAAACTGGCTGGACAAAGCACGCGTATCGAACACGCTTGTGAAGCCGCCATGTTGATGAGCGACAACACCGCCGCAAACTTAGTGCTAAATGAAATTGGTGGTCCTAAAGCGGTCACGCTGTTTTTGCGCTCTATTGGCGACAAAGCAACGCGACTTGACCGATTGGAGCCCCGTTTGAACGAAGCAAAACCGGGCGACAAGCGAGACACCACAACGCCTAACGCCATGGTAAACACCCTACACACCTTGATGGAAGATAACGCCCTATCTTACGAGTCACGCACACAGCTGAAAATCTGGATGCAAGACAACAAAGTATCGGATTCTCTCATGCGCTCTGTTCTACCAAAAGGCTGGTCGATTGCAGACCGCTCTGGCGCAGGTAACTACGGTTCACGCGGCATTAGCGCGATGATTTGGAAAGACAACTACAAGCCGGTTTACATCAGTATTTACGTCACAGATACTGACCTTTCGCTTCAAGCTCGCGATCAACTGATCGCGCAAATCAGCCAACTGATTTTAGAGCACTACAAAGAAAGTTAAGCTCGAACTCGAGCAACCAAGCCCTTCTCATTCAGAGGGGCTTTTTCTTACCTGCTCTCTCAAATTCTTAACAAATCTCTCTTATTCTTGCTGTCTTCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Vibrio", "NCBI_taxonomy_id": "662", "NCBI_taxonomy_cvterm_id": "37072"}, "protein_sequence": {"GI": "WP_020835015.1", "sequence": "MKKLFLLVGLMVCSTVSYASKLNEDISLIEKQTSGRIGVSVWDTQTDERWDYRGDERFPLMSTFKTLACATMLSDMDSGKLNKNATARIDERNIVVWSPVMDKLAGQSTRIEHACEAAMLMSDNTAANLVLNEIGGPKAVTLFLRSIGDKATRLDRLEPRLNEAKPGDKRDTTTPNAMVNTLHTLMEDNALSYESRTQLKIWMQDNKVSDSLMRSVLPKGWSIADRSGAGNYGSRGISAMIWKDNYKPVYISIYVTDTDLSLQARDQLIAQISQLILEHYKES"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "CARB-20", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39727", "model_name": "CARB-20", "model_type_id": "40292"}, "2112": {"model_id": "2112", "ARO_accession": "3000025", "model_param": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance..", "model_sequences": {"sequence": {"3693": {"dna_sequence": {"fmax": "1360395", "fmin": "1359228", "accession": "NC_003098.1", "strand": "-", "sequence": "TTAACATTTGGCAAAAGTAGCCACAATCCGCTGACAGACTTCTTGCAACAGAGATTTGGGCATAGCTATATTGATGCGGGCATGGAGACTTCCTTCCTCTCCAAAATCCAAACCACGGTTGAGGATAACCTTGGCTTCATTTCTCAACAACTCTTGCAATGTTTCATCAGTCAGGTCATAAGCTGAAAAGTCAAGCCAAATCAAGTAGGTACCTTGCGGTTTCATGACCTTGATTTTAGTCTCTTTTCCAAATAGATCCACCACATAATTGATGTGGTCTTCAAAGACTTGCTTGAGTTCCTCTAGCCAATCTTTACCGTATCGATAGGCAGCTTCTGTCGCCAAATAACCCAAGCCTGAAATTTCATGCTGATTATTGGCCAACAGGCGTTTCTGGAAAGCCAGTCTCAACTTAGGATTTTCAATGACTGCATAGGAATTTTTTGTTCCAGCAATATTAAATGTTTTAGTGGCACTGCTCAAGACGATAGCAAAATTTTTGAAGGCAGGATTGATGGTATTGAAAGACTGGTGTTTGTGACCAAAGAGGGTCAAATCTTGGTGAATCTCATCCGAAACTAACAAAACACCGTGTTTTTGGCAGAGTTGGCCAATCTTCTCCAACACTTCTTTTTCCCAAACACGTCCACCAGGATTGTGAGGGTTGCAAAGAACATAGAGTTTAACCTCCTCTTCCACCAAATCCTTTTCAAGTTGGTCAAAGTCAATCTCAAACAGACTATCCTTTTCCACTAAGGAATTAGTAATCAATCTACGATTATTCAACTTGACACTGCGAGCAAAGGGTGGGTAGACAGGCGTGTTAATTAAAACCGCCTCGCCTTCTTTTGTAAAGGTTTGAATAGCTGTTGAGATGGCTGGTACCACACCCTCGATAAAGACAAGAGCCTCTTTGTCAAAGTTGTAACCGTATTGTGTAGCTTCCCACTTTTGAACTTCCTTAATTAAGTCTTCACTGGCATAGGTATAACCATAAACCAGTTGGTCTGCGTAAGTTTGCACGGCTTGGTGGATTTCAGGCAAGACTACAAAGTCCATATCCGCTATCCAAGCTGGTAGAACTTCACTATCCGTTTCTGTTTCTTTCCATTTATAGGTATGGTGCCCTAAACGGTTGGGCAGGCTTGTAAAATCATATTTTCCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus pneumoniae R6", "NCBI_taxonomy_id": "171101", "NCBI_taxonomy_cvterm_id": "39596"}, "protein_sequence": {"GI": "NP_358969.1", "sequence": "MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPEIHQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAIQTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEEVKLYVLCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTINPAFKNFAIVLSSATKTFNIAGTKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLATEAAYRYGKDWLEELKQVFEDHINYVVDLFGKETKIKVMKPQGTYLIWLDFSAYDLTDETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKC"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "patB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "36034", "model_name": "patB", "model_type_id": "40292"}, "2114": {"model_id": "2114", "ARO_accession": "3002644", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "APH(3')-IIa is a transposon-encoded aminoglycoside phosphotransferase in E. coli", "model_sequences": {"sequence": {"3689": {"dna_sequence": {"fmax": "995", "fmin": "0", "accession": "NG_047417.1", "strand": "+", "sequence": "GAAGCCCTGCAAAGTAAACTGGATGGCTTTCTTGCCGCCAAGGATCTGATGGCGCAGGGGATCAAGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacteria", "NCBI_taxonomy_id": "2", "NCBI_taxonomy_cvterm_id": "35506"}, "protein_sequence": {"GI": "WP_000572405.1", "sequence": "MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}}, "ARO_name": "APH(3')-IIa", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39044", "model_name": "APH(3')-IIa", "model_type_id": "40292"}, "2115": {"model_id": "2115", "ARO_accession": "3000876", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "TEM-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates.", "model_sequences": {"sequence": {"3688": {"dna_sequence": {"fmax": "1061", "fmin": "0", "accession": "NG_050265", "strand": "+", "sequence": "AACCCCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGCTCATGAGACAATAACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCTTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTAAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCAGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACATGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"GI": "WP_063864911.1", "sequence": "MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "TEM-4", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "37256", "model_name": "TEM-4", "model_type_id": "40292"}, "2117": {"model_id": "2117", "ARO_accession": "3002578", "model_param": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii", "model_sequences": {"sequence": {"3683": {"dna_sequence": {"fmax": "980", "fmin": "0", "accession": "Y11946.1", "strand": "+", "sequence": "CTGTTCGGTTCGTAAACTGTAATGCAAGTAGCGTATGCGCTCACGCAACTGGTCCAGAACCTTGACCGAACGCAGCGGTGGTAACGGCGCAGTGGCGGTTTTCATGGCTTGTTATGACTGTTTTTTTGTACAGTCTATGCCTCGGGCATCCAAGCAGCAAGCGCGTTACGCCGTGGGTCGATGTTTGATGTTATGGAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAACCCTTCCATCGAGGACGTCCACGGGCTGGCGCCTTGGCCGCCCCTCATGTCAAACGTTAGACATCATGAGGGTAGCGGTGACCATCGAAATTTCGAACCAACTATCAGAGGTGCTAAGCGTCATTGAGCGCCATCTGGAATCAACGTTGCTGGCCGTGCA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Corvallis", "NCBI_taxonomy_id": "593905", "NCBI_taxonomy_cvterm_id": "35906"}, "protein_sequence": {"GI": "AKN19287.1", "sequence": "MRSRNWSRTLTERSGGNGAVAVFMACYDCFFVQSMPRASKQQARYAVGRCLMLWSSNDVTQQGSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}}, "ARO_name": "AAC(6')-Ib7", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "38978", "model_name": "AAC(6')-Ib7", "model_type_id": "40292"}, "2387": {"model_id": "2387", "ARO_accession": "3003908", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Chromosome-encoded gene conferring MLSB resistance. Identified from Helcococcus kunzii.", "model_sequences": {"sequence": {"3705": {"dna_sequence": {"fmax": "81078", "fmin": "80337", "accession": "KU612222.1", "strand": "+", "sequence": "ATGAACAGAAAAAGTGTTAGATTTGGACAAAATTTTGTAACTTCTATTAATGATATAAACAAAATATGTAAGAAGATAGACGTGAATTCTAATGATGTTTATTTTGAAATTGGTCCAGGTAAAGGGCATTTTACTCAATACTTTGTGGAAAGGGCTAAAGAGGTAATTGCTATTGAAATAGACAGTGAATTAATTCCTATATTAAACAACAAATTTTCAGATCTAGATAATATAAAAATTATTAATCATGACTTTATGTCTTATGAATTACCATCTACATTTAAGTATAAAGTTTTTGGAAATATTCCATTTAATTTGAGTACTTCTATTATTCGTAAACTTAGTTTAGAAAAATATGCAGATGAGATTTACTTAATAGTGGAATTAGGGTTTGCAAAAAGATTAGAAGACTTAAACCGTAAAATGGGACTAATGTTAGCTCCATTTTATGAAATTTCAATTTTATACAATATTCCAAAAAGATATTTTCATCCCATACCCAGTGTTGAGGTAGTGCTGATAAAACTAAAAAGAACTTCCTATAATATGTCCATGAAAGAATATATAAAGTATGAAGACTTTATAGAAAAATGGGTAAAAAAGGATTATAATGTTTTATTTACAAAAAATCAGCTAAAACAAGCAATCAGATATGGAAATATTGATAATTTAAGAATCCTAAAAGTTGATCAAATTCTATCCATATTTGAAAGTTACAAATTATTTAATGGGTTAAAGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helcococcus kunzii", "NCBI_taxonomy_id": "40091", "NCBI_taxonomy_cvterm_id": "40615"}, "protein_sequence": {"GI": "ANZ79476.1", "sequence": "MNRKSVRFGQNFVTSINDINKICKKIDVNSNDVYFEIGPGKGHFTQYFVERAKEVIAIEIDSELIPILNNKFSDLDNIKIINHDFMSYELPSTFKYKVFGNIPFNLSTSIIRKLSLEKYADEIYLIVELGFAKRLEDLNRKMGLMLAPFYEISILYNIPKRYFHPIPSVEVVLIKLKRTSYNMSMKEYIKYEDFIEKWVKKDYNVLFTKNQLKQAIRYGNIDNLRILKVDQILSIFESYKLFNGLK"}}}}, "ARO_category": {"36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}, "36380": {"category_aro_name": "lincosamide resistance gene", "category_aro_cvterm_id": "36380", "category_aro_accession": "3000241", "category_aro_description": "Genes conferring resistance to lincosamides."}, "36454": {"category_aro_name": "macrolide resistance gene", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Genes or their products conferring resistance to macrolide antibiotics."}, "36379": {"category_aro_name": "streptogramin resistance gene", "category_aro_cvterm_id": "36379", "category_aro_accession": "3000240", "category_aro_description": "Genes conferring resistance to streptogramin antibiotics."}}, "ARO_name": "Erm(47)", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40614", "model_name": "Erm(47)", "model_type_id": "40292"}, "2401": {"model_id": "2401", "ARO_accession": "3003924", "model_param": {"blastp_evalue": {"param_value": "1e-190", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4438": "S84Y"}, "clinical": {"4438": "S84Y"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutation of Haemophilus parainfluenzae gyrA resulted in the lowered affinity between fluoroquinolones and GyrA. Thus, conferring resistance. Both Ser and Tyr are hydrophilic amino acids, however Tyr has an additional bulky hydrophobic group which could affect the interaction between the DNA gyrase with quinolones", "model_sequences": {"sequence": {"3727": {"dna_sequence": {"fmax": "1999166", "fmin": "1996520", "accession": "NC_015964.1", "strand": "+", "sequence": "ATGACGGATTCAATCCATTCCTCTATTACCCCAGTCAATATTGAAGAAGAACTAAAATCTTCTTACCTTGACTACGCCATGTCGGTGATTGTTGGGCGTGCTTTGCCTGATGTGCGTGACGGTTTAAAACCGGTGCATCGACGTGTGCTTTTCTCCATGGATCAATCTGGCATCACTGCCGGCAAAAAATACGTAAAATCTGCCCGTGTGGTAGGTGATGTAATCGGTAAATATCACCCGCACGGTGATTCTGCAGTGTACGACACCATTGTGCGTATGGCACAGCCGTTCTCATTGCGCTACATGTTGGTAGATGGGCAAGGTAACTTCGGTTCAATCGACGGTGATGCGCCAGCGGCAATGCGTTATACCGAAGTCCGTATGCAAAAAATCACCCAAGCGTTATTAACTGACTTGGATAAAGAAACCGTAAATTTCTCGCCAAACTATGATGGCGAATTAATGATTCCGGATGTATTACCAACTCGTATTCCTGCACTTTTAGCAAACGGTTCTTCCGGTATTGCGGTGGGGATGGCAACCAACATTCCACCACACAACTTAAATGAAGTTTTAGATGGATGCTTGGCTTATATTGATAACGAAAACATCACCATTGATGAGTTAATGCAATATATCCCGGGCCCAGACTTCCCAACAGCGGCATTAATTAATGGCCGTAAAGGGATTGAAGAAGCTTATCGCACTGGTCGCGGCAAAGTGTATGTTCGCGCTCGCGCTAGCGTAGAAACCACAGATAAAGGCAAAGAGCAAATTATTGTGACCGAATTGCCTTATCAAGTGAACAAAGCCAAATTAGTGGAAAAAATTGCTGAGCTTATCAAAGATAAAAAAATCGAAGGCATCAGCAATATTATCGACCTTTCGAACAAAGAAGGGATTCGCATTGAAATTGACATCAAACGTGATGCCGTAGGCGAAGTAGTATTAAATCACCTCTATGCGCTTACCCAAATGCAGGTAACCTTCGGGATTAACATGGTGGCCTTGGATCACGGTCAACCACGTTTATTCAACTTAAAACAAATCATTGAAGCCTTTGTGATGCACCGTCGCGAAGTGGTGATTCGCCGTTCTTTATTTGAATTGCGTAAAGCCCGCGAGCGTACCCATATTTTAGAAGGTTTAGCGGTTGCAACATCAAATATCGATGAAATCATCGATATCATCCGTCAATCGAAAGAGCGTAAAGAAGCGGCAGAAAAATTAATCTCTCGCCCTTGGAAATTGAATAACGAAATTTTAGGTTTACTTGATGCAGCGGCACGTCCAGCTGAGTTAGCGGCTGAATTTGGTATTAAAGGTTCGGATTACTATCTTTCTCCAGAACAAGTTGATGCAATCTTAGAACTTCGCTTGCATCGTTTAACCGGTCTTGCTACCGAAGAAGTAATCAATGAATACAAAGAGTTATTGGTTAAAATTGCAGAACTTCTCCACATCATCAACAGCCCTGAGCGTTTGATGGAAGTGATTCGTGAAGAGCTTGAACAAGTACGCGCACAATTCGCGGATGAACGTCGTACCGAAATTACTGCGGCTTCTGGTGATATTGATTTAGAAGATTTAATTGCTCAAGAAGATGTGGTAGTGACCCTTTCTCACGAAGGTTATGTGAAATATCAACCGCTTACCGACTACGAAGCACAACGTCGTGGTGGTAAAGGTAAATCCGCAACGAAGATGAAAGATGAAGACTTCATTGAAAAACTCTTAGTAGCGAATACTCACGATACGATTCTCTGTTTCTCTAGCCGCGGTCGCTTATATTGGTTGAAAGTCTATCAATTACCACAAGCAAGCCGTGGTGCGCGTGGTCGTCCGATTGTGAATATTCTACCGTTGCAAGAAAACGAGCGTATCACCGCAATCTTGCCAATCTCTGCTTATGAAGAAGATAAATTCGTCATCATGGCAACGGCTGGTGGTATTGTGAAGAAAATTGCGCTAACCGAATTCAGCCGTCCACGTTCAAGCGGTATCATCGCCTTGAACTTACGTGATGAAGATGAATTAATCGGCGTGGATATCACCGATGGTTCTAACGAAATCATGTTGTTCTCTTCGCAAGGTCGCGTAGTACGTTTCGCTGAAAGTGCAGTGCGTGCAATGGGTCGTTTAGCAACAGGTGTACGCGGTATTAAACTCGCCCTAACCAACGACATCGCTGACGATGAAAGTGCGGTCGAAATTGAAGAGGTTTCCGATGATAATGCAGAAGAAACCCTCGATCTCAATATCGATAAAGTGGTTTCCTTAGTTGTGCCGAAAAATGACGGCGCAATCCTTACGGCGACGCAAAACGGTTACGGTAAACGCACACAATTAAGCGAATACCCAACCAAATCCCGTAATACCAAAGGGGTGATTTCGATTAAAGTGAGCGAACGTAACGGTAAAGTCGTTGCGGCGACACAAGTGGAAGAAACCGACCAAATTATGCTTATCACTGATGCGGGTACCTTAGTGCGTACTCGTGTAAGTGAAGTGAGCATCGTTGGCCGTAACACCCAAGGGGTTCGTTTAATTCGTACCGCAGAAGATGAGCACGTAGTCAGTCTTGAACGTGTTTGTGATGTGGATGATGAAGACGAAGGCACTGAAGATGTGACTTCTGAAGAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Haemophilus parainfluenzae", "NCBI_taxonomy_id": "729", "NCBI_taxonomy_cvterm_id": "36927"}, "protein_sequence": {"GI": "WP_014065640.1", "sequence": "MTDSIHSSITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQSGITAGKKYVKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQALLTDLDKETVNFSPNYDGELMIPDVLPTRIPALLANGSSGIAVGMATNIPPHNLNEVLDGCLAYIDNENITIDELMQYIPGPDFPTAALINGRKGIEEAYRTGRGKVYVRARASVETTDKGKEQIIVTELPYQVNKAKLVEKIAELIKDKKIEGISNIIDLSNKEGIRIEIDIKRDAVGEVVLNHLYALTQMQVTFGINMVALDHGQPRLFNLKQIIEAFVMHRREVVIRRSLFELRKARERTHILEGLAVATSNIDEIIDIIRQSKERKEAAEKLISRPWKLNNEILGLLDAAARPAELAAEFGIKGSDYYLSPEQVDAILELRLHRLTGLATEEVINEYKELLVKIAELLHIINSPERLMEVIREELEQVRAQFADERRTEITAASGDIDLEDLIAQEDVVVTLSHEGYVKYQPLTDYEAQRRGGKGKSATKMKDEDFIEKLLVANTHDTILCFSSRGRLYWLKVYQLPQASRGARGRPIVNILPLQENERITAILPISAYEEDKFVIMATAGGIVKKIALTEFSRPRSSGIIALNLRDEDELIGVDITDGSNEIMLFSSQGRVVRFAESAVRAMGRLATGVRGIKLALTNDIADDESAVEIEEVSDDNAEETLDLNIDKVVSLVVPKNDGAILTATQNGYGKRTQLSEYPTKSRNTKGVISIKVSERNGKVVAATQVEETDQIMLITDAGTLVRTRVSEVSIVGRNTQGVRLIRTAEDEHVVSLERVCDVDDEDEGTEDVTSEE"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40633", "model_name": "Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2405": {"model_id": "2405", "ARO_accession": "3003929", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4455": "E91G", "4454": "S87R"}, "clinical": {"4455": "E91G", "4454": "S87R"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutations in Neisseria gonorrhoeae parC protein that confer resistance to fluoroquinolone by reducing affinity to antibiotic binding site", "model_sequences": {"sequence": {"3731": {"dna_sequence": {"fmax": "1212827", "fmin": "1210523", "accession": "NC_002946.2", "strand": "+", "sequence": "ATGAATACGCAACCGCACGCTTCCCATACCGATTCCAACACGCTGATGCTCGGCCGATACGCCGAACGCGCCTATCTCGAATACGCCATGAGCGTGGTCAAAGGCCGCGCGCTGCCTGAAGTTTCAGACGGCCAAAAGCCCGTGCAGCGGCGCATTTTGTTTGCCATGCGCGATATGGGTTTGACGGCGGGGGCGAAGCCGGTGAAATCGGCGCGCGTGGTCGGCGAGATTTTGGGTAAATACCATCCGCACGGCGACAGTTCCGCCTATGAGGCGATGGTGCGCATGGCTCAGGATTTTACCTTGCGCTACCCCTTAATCGACGGCATCGGCAACTTCGGTTCGCGCGACGGCGACGGGGCGGCGGCGATGCGTTACACCGAAGCGCGGCTGACGCCGATTGCGGAATTGCTGTTGTCCGAAATCAATCAGGGGACGGTGGATTTTATGCCGAACTACGACGGCGCGTTTGACGAGCCGCTGCACCTTCCCGCCCGCTTGCCTATGGTGTTGCTCAACGGCGCGTCGGGCATCGCGGTGGGTATGGCGACCGAGATTCCGTCGCACAATTTGAACGAAGTCACGCAGGCGGCGATTGCACTGTTGAAGAAACCGACGCTGGAAACCGCCGACCTGATGCAATATATTCCTGCTCCCGATTTTGCCGGCGGCGGTCAAATCATCACGCCGGCGGACGAATTGCGCCGTATTTACGAAACCGGCAAGGGCAGCGTGCGCGTGCGTGCGCGTTATGAAATCGAGAAATTGGCGCGCGGACAGTGGCGCGTCATCGTAACCGAACTGCCGCCGAACGCCAACTCCGCCAAAATCCTTGCCGAAATCGAAGAGCAAACCAACCCGAAACCGAAAGCGGGTAAAAAGCAGCTCAACCAAGACCGGCTCAATACCAAAAAGCTGATGCTGGATTTAATCGACCGCGTGCGCGACGAGTCCGACGGCGAACATCCCGTGCGCCTTGTATTTGAACCGAAATCCAGCCGCATCGATACCGATACCTTCATCAACACGCTGATGGCGCAAACTTCGCTGGAAGGCAATGTGTCCATGAACTTGGTGATGATGGGTTTGGACAACCGCCCCGCGCAGAAAAACCTGAAAACGATTTTGCAGGAATGGCTGGATTTCCGCGTCGTTACCGTAACACGCCGTCTGAAATTCCGTTTAAACCAAGTGGAAAAACGGCTGCACATCCTCGAAGGCCGTCTGAAAGTCTTTCTGCACATCGACGAAGTGATTAAAGTCATCCGCGAATCGGACGACCCGAAAGCCGATTTGATGGCGGTGTTCGGGCTGACCGAAATCCAAGCCGAAGACATTTTGGAAATCCGCCTGCGTCAGCTGGCGCGTTTGGAAGGTTTCAAACTCGAAAAAGAATTGAACGAATTGCGCGAAGAACAAGGCCGTCTGAATATCTTTTTGGGCGACGAAAACGAAAAACGCAAGCTGATTATCAAAGAGATGCAGGCGGACATGAAGCAGTTCGGCGACGCGCGCCGCACGCTGGTGGAAGAGGCCGGACGCGCCGTGCTGACACAAACCGCCGCCGACGAACCCATCACGCTGATTTTGTCGGAAAAAGGCTGGATACGCAGCCGTGCCGGACATAATCTCGATTTGAGCCAAACCGCGTTCAAAGAAGGCGACCGCCTCAAACAAACCCTTGAAGGCCGCACTGTTTTACCCGTCGTCATCCTCGATTCATCGGGCAGAACCTACTCGATCGATGCCGCCGAAATCCCCGGCGGACGCGGCGACGGCGTACCGGTTTCCTCCTTAATCGAGTTGCAAAACGGCGCGAAACCCGTCGCGATGTTGACAGGATTGCCGGAACAACATTATTTATTATCAAGCAGCGGCGGCTACGGCTTTATCGCCAAGCTGGGCGATATGGTCGGACGCGTGAAAGCGGGCAAAGTGGTGATGACCGCAGACAGCGGCGAAACCGTCCTGCCGCCGGTTGCCGTCTATGCCTCCTCGTTCATCAACCCCGACTGCAAAATCATTGCAGCCACCAGTCAAAACCGCGCCCTCGCCTTCCCCATCGGCGAATTGAAAATTATGGCGAAAGGCAAAGGACTGCAAATCATCGGATTAAACGCCGGCGAATCGATGACGCATACCGCCGTTTCTTCCGAGCCGGAAATCCTGATTGAAAGCGAAGGCAGGCGCGGCGCGGCGCACAAAGACCGCCTCCCCGTCGCCCTGATTGAGGCAAAACGCGGCAAAAAAGGCAGACTGTTGCCCATATCGGGCAGCCTGAAACAGCTTTCTTCCCCCAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae FA 1090", "NCBI_taxonomy_id": "242231", "NCBI_taxonomy_cvterm_id": "40638"}, "protein_sequence": {"GI": "YP_208330.1", "sequence": "MNTQPHASHTDSNTLMLGRYAERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLTAGAKPVKSARVVGEILGKYHPHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAAAMRYTEARLTPIAELLLSEINQGTVDFMPNYDGAFDEPLHLPARLPMVLLNGASGIAVGMATEIPSHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPADELRRIYETGKGSVRVRARYEIEKLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGKKQLNQDRLNTKKLMLDLIDRVRDESDGEHPVRLVFEPKSSRIDTDTFINTLMAQTSLEGNVSMNLVMMGLDNRPAQKNLKTILQEWLDFRVVTVTRRLKFRLNQVEKRLHILEGRLKVFLHIDEVIKVIRESDDPKADLMAVFGLTEIQAEDILEIRLRQLARLEGFKLEKELNELREEQGRLNIFLGDENEKRKLIIKEMQADMKQFGDARRTLVEEAGRAVLTQTAADEPITLILSEKGWIRSRAGHNLDLSQTAFKEGDRLKQTLEGRTVLPVVILDSSGRTYSIDAAEIPGGRGDGVPVSSLIELQNGAKPVAMLTGLPEQHYLLSSSGGYGFIAKLGDMVGRVKAGKVVMTADSGETVLPPVAVYASSFINPDCKIIAATSQNRALAFPIGELKIMAKGKGLQIIGLNAGESMTHTAVSSEPEILIESEGRRGAAHKDRLPVALIEAKRGKKGRLLPISGSLKQLSSPK"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Neisseria gonorrhoeae parC conferring resistance to fluoroquinolone", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40639", "model_name": "Neisseria gonorrhoeae parC conferring resistance to fluoroquinolone", "model_type_id": "40293"}, "2079": {"model_id": "2079", "ARO_accession": "3000862", "model_param": {"blastp_evalue": {"param_value": "1e-30", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Sgm, or sisomicin-gentamicin methyltransferase, methylates G1405 of 16S rRNA to confer resistance to various aminoglycosides.", "model_sequences": {"sequence": {"3696": {"dna_sequence": {"fmax": "925", "fmin": "100", "accession": "NG_050600", "strand": "+", "sequence": "ATGACGGCACCTGCGGCCGACGACCGTATCGACGAGATTGAGCGGGCCATCACCAAGAGCAGGCGTTACCAGACGGTGGCGCCGGCCACCGTGCGCCGCCTGGCCCGCGCTGCTCTCGTCGCCGCGCGGGGTGACGTGCCCGACGCGGTGAAGCGCACCAAGCGGGGTCTGCACGAGATCTACGGCGCCTTCCTGCCGCCCAGCCCTCCCAACTACGCAGCGTTGCTGCGGCACCTGGACTCGGCAGTGGACGCCGGTGACGACGAGGCGGTTCGAGCGGCCCTACTTCGCGCTATGTCCGTACATATCTCCACCCGCGAGCGATTGCCGCACCTCGACGAGTTCTACCGGGAACTCTTCCGGCACCTCCCCCGACCGAACACGCTGCGTGACCTCGCCTGTGGTCTCAACCCCCTGGCCGCGCCCTGGATGGGCCTGCCCGCCGAGACCGTCTACATCGCCTCGGACATCGACGCCCGCCTGGTCGGCTTCGTGGACGAGGCCCTGACCCGACTCAATGTTCCACATCGGACGAACGTGGCCGACCTGCTCGAGGACCGTCTTGACGAGCCGGCCGACGTCACGCTATTGCTGAAGACGCTGCCCTGTCTGGAGACTCAGCAACGAGGATCGGGCTGGGAAGTGATTGACATTGTCAACTCGCCGAATATCGTGGTAACCTTCCCGACCAAGTCTCTCGGTCAGCGATCGAAGGGGATGTTTCAGAACTATTCACAGAGTTTTGAGTCCCAGGCCAGAGAGCGGTCATGCCGTATTCAGCGACTGGAGATTGGCAACGAGCTGATTTACGTCATTCAGAAATAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Micromonospora zionensis", "NCBI_taxonomy_id": "1879", "NCBI_taxonomy_cvterm_id": "40607"}, "protein_sequence": {"GI": "WP_063978071.1", "sequence": "MTAPAADDRIDEIERAITKSRRYQTVAPATVRRLARAALVAARGDVPDAVKRTKRGLHEIYGAFLPPSPPNYAALLRHLDSAVDAGDDEAVRAALLRAMSVHISTRERLPHLDEFYRELFRHLPRPNTLRDLACGLNPLAAPWMGLPAETVYIASDIDARLVGFVDEALTRLNVPHRTNVADLLEDRLDEPADVTLLLKTLPCLETQQRGSGWEVIDIVNSPNIVVTFPTKSLGQRSKGMFQNYSQSFESQARERSCRIQRLEIGNELIYVIQK"}}}}, "ARO_category": {"36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}, "36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}}, "ARO_name": "sgm", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "37242", "model_name": "sgm", "model_type_id": "40292"}, "2071": {"model_id": "2071", "ARO_accession": "3002579", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae", "model_sequences": {"sequence": {"3719": {"dna_sequence": {"fmax": "4849", "fmin": "4171", "accession": "NC_025003.1", "strand": "+", "sequence": "ATGAGCCTTAAACCCGGACCAAAAAGAATTGCCGAATCGACGGGGCAACCTGATCAACGCCAACGCGACAATAAAAAGACGCCTGGAAATACTGACAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCACCGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550", "NCBI_taxonomy_cvterm_id": "36884"}, "protein_sequence": {"GI": "YP_009062819.1", "sequence": "MSLKPGPKRIAESTGQPDQRQRDNKKTPGNTDKLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}}, "ARO_name": "AAC(6')-Ib8", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "38979", "model_name": "AAC(6')-Ib8", "model_type_id": "40292"}, "2121": {"model_id": "2121", "ARO_accession": "3002486", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "LRA-7 is a beta-lactamase isolated from soil samples in Alaska", "model_sequences": {"sequence": {"3698": {"dna_sequence": {"fmax": "8479", "fmin": "7570", "accession": "EU408356.1", "strand": "+", "sequence": "ATGCGGTCGAAATTCCTGCTTGCTACTGCGCTCGTTCTGTCGACGGCCTTCACCGCCGATGCAGCAGACGCGCCGAAGCGCCTTCCCGTCAACATCACCAACCAGGATTGGCTGAAGCCGTTTCCGGGATTCAAGATCGTCGGCAACATGTATTATGTCGGCACCTACGATCTCGGCTGCTACCTGATCGATACCGGCGCAGGGCTGATCCTCGTCAACACCGGCATCATGGGTTCCTACCCGCTGATGAAGGCGAGCATCGAATCCCTCGGCTTCAAGACCAGCGACATCAAGATTATCACCGCGACGCATGGCCATTCCGACCATGTCGCCGATATGGCGTCGTTCAAGAAGGACGCGCCGAGCGCCGTCGTCTATATGAGCGAGCGCGATGTGGAGAGCCTCGAAAGCGGCGGTAATTTCGATTACCGCCGCCCCGCACCGGAAGGCCGTGGCGGTCTCGTCTATGATCCCATCCATGTCGATGTGAAGACGAAGCCCGGCGATCACATCAAGCTCGGCAATGTCGATATGACCGTGCTGCAGGCCTATGGCCACACGCCGGGCGCGACGAGCTTCCAATTCCAGCAGACGGATGCGGGCAAGACCTACAATGTGATGATCGTGAACATGAACGGCATCAACGCCGGCGTTAAGCTGCTGGGTTCGCCGAAATATCCGACCATCGTCGAGGACTTCAAGAACACCATCGACATGCAGGCGACGTACAAGCCCGACATCTGGGTGTCGTCGCATGCGGGGCAGTTCAACCTGCATCAGGTCTATAAGCCGGGCGATGCGTACAATCCGGCCCGCTTCGGCGATCAGGCCGCCTATCAGCAGAAGATCGCGACCGCGAAGGCGAATTACGAGAAGCAGCTCGCCGAGGAACGCGCGGCGGCGAAATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "uncultured bacterium BLR7", "NCBI_taxonomy_id": "506523", "NCBI_taxonomy_cvterm_id": "39087"}, "protein_sequence": {"GI": "ACH58998.1", "sequence": "MRSKFLLATALVLSTAFTADAADAPKRLPVNITNQDWLKPFPGFKIVGNMYYVGTYDLGCYLIDTGAGLILVNTGIMGSYPLMKASIESLGFKTSDIKIITATHGHSDHVADMASFKKDAPSAVVYMSERDVESLESGGNFDYRRPAPEGRGGLVYDPIHVDVKTKPGDHIKLGNVDMTVLQAYGHTPGATSFQFQQTDAGKTYNVMIVNMNGINAGVKLLGSPKYPTIVEDFKNTIDMQATYKPDIWVSSHAGQFNLHQVYKPGDAYNPARFGDQAAYQQKIATAKANYEKQLAEERAAAK"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "LRA-7", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "38886", "model_name": "LRA-7", "model_type_id": "40292"}, "2123": {"model_id": "2123", "ARO_accession": "3002831", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "vgaC is an efflux protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA.", "model_sequences": {"sequence": {"3686": {"dna_sequence": {"fmax": "102430", "fmin": "102199", "accession": "KU302801", "strand": "+", "sequence": "ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAGCGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGGACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550", "NCBI_taxonomy_cvterm_id": "36884"}, "protein_sequence": {"GI": "AMP35312.1", "sequence": "MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36379": {"category_aro_name": "streptogramin resistance gene", "category_aro_cvterm_id": "36379", "category_aro_accession": "3000240", "category_aro_description": "Genes conferring resistance to streptogramin antibiotics."}, "40410": {"category_aro_name": "pleuromutilin resistance gene", "category_aro_cvterm_id": "40410", "category_aro_accession": "3003753", "category_aro_description": "Genes conferring resistance to pleuromutilin"}}, "ARO_name": "vgaC", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39265", "model_name": "vgaC", "model_type_id": "40292"}, "2081": {"model_id": "2081", "ARO_accession": "3000024", "model_param": {"blastp_evalue": {"param_value": "1e-110", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance.", "model_sequences": {"sequence": {"3692": {"dna_sequence": {"fmax": "3220873", "fmin": "3219493", "accession": "NC_000913.3", "strand": "+", "sequence": "TTGAACAGGTTACCTTCGAGCGCATCGGCTTTAGCGTGCAGCGCCCACGCCCTGAATCTCATTGAGAAGCGAACGCTGGATCATGAGGAGATGAAAGCACTTAACCGAGAGGTGATTGAATACTTCAAAGAGCATGTCAATCCGGGGTTTTTAGAGTATCGCAAATCTGTTACCGCCGGCGGGGATTACGGAGCCGTAGAGTGGCAAGCGGGAAGTTTAAATACGCTTGTCGACACCCAGGGCCAGGAGTTTATCGACTGCCTGGGAGGTTTTGGAATTTTCAACGTGGGGCACCGTAATCCAGTTGTGGTTTCCGCCGTACAGAATCAACTTGCGAAACAACCGCTGCACAGCCAGGAGCTGCTCGATCCGTTACGGGCGATGTTGGCGAAAACCCTTGCTGCGCTAACGCCCGGTAAACTGAAATACAGCTTCTTCTGTAATAGCGGCACCGAGTCCGTTGAAGCAGCGCTGAAGCTGGCGAAAGCTTACCAGTCACCGCGCGGCAAGTTTACTTTTATTGCCACCAGCGGCGCGTTCCACGGTAAATCACTTGGCGCGCTGTCGGCCACGGCGAAATCGACCTTCCGCAAACCGTTTATGCCGTTACTGCCGGGCTTCCGTCATGTGCCGTTTGGCAATATCGAAGCCATGCGCACGGCTCTTAACGAGTGCAAAAAAACCGGTGATGATGTGGCTGCGGTGATCCTCGAACCGATTCAGGGTGAAGGTGGCGTAATTCTGCCGCCGCCGGGCTATCTCACCGCCGTACGTAAGCTATGCGATGAGTTCGGCGCACTGATGATCCTCGATGAAGTACAAACGGGCATGGGGCGCACGGGCAAGATGTTCGCCTGCGAGCATGAGAACGTACAGCCGGATATCCTCTGCCTTGCCAAAGCGCTCGGCGGCGGCGTGATGCCGATTGGCGCGACCATCGCCACTGAAGAGGTGTTTTCAGTTCTGTTCGACAACCCATTCCTGCATACCACCACCTTTGGCGGCAACCCGCTGGCCTGTGCGGCGGCGCTGGCGACCATCAATGTGTTGCTGGAGCAGAACTTACCGGCTCAGGCTGAGCAAAAAGGCGATATGTTGCTGGACGGTTTCCGTCAACTGGCGCGGGAATATCCCGATCTGGTACAGGAAGCGCGTGGTAAAGGGATGTTGATGGCGATTGAGTTTGTTGATAACGAAATCGGCTATAACTTTGCCAGCGAGATGTTCCGCCAGCGCGTACTGGTGGCCGGAACGCTCAATAACGCCAAAACGATCCGCATTGAACCGCCACTGACACTGACCATTGAACAGTGTGAACTGGTGATCAAAGCGGCGCGTAAGGCGCTGGCGGCCATGCGAGTAAGTGTCGAAGAAGCGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_417544.5", "sequence": "MNRLPSSASALACSAHALNLIEKRTLDHEEMKALNREVIEYFKEHVNPGFLEYRKSVTAGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPPPGYLTAVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLDGFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCELVIKAARKALAAMRVSVEEA"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "patA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "36033", "model_name": "patA", "model_type_id": "40292"}, "2396": {"model_id": "2396", "ARO_accession": "3001555", "ARO_description": "OXA-368 is a beta-lactamase found in Aeromonas sobria. From the Lahey list of OXA beta-lactamases.", "model_sequences": {"sequence": {"3721": {"dna_sequence": {"fmax": "2721", "fmin": "0", "accession": "KT736121.1", "strand": "+", "sequence": "TCAGCCGGGCGACAAGTGCAAGGCCAAGGCGTCCAGCGGGCTGGAGGTGCCTCCGGCAGCGACTTTCAGCACATGCGTGTAGATCATCGTCGTGCTCACGTCCGAATGCCCCAACAACTCTTGCACCGTTCGGATGTCTGTGCCTGCTTGCAGCAAGTGGGTGGCGAATGAGTGGCGCAGGGTGTGGACAGATACGTGTTTGGCAATGCCAGCCTGAACTACCGCTTTTTTTAGTTGCCGGTTCAGTCTTTCCTCAAACAAGTGGTGGCGGCGCTCAACGCCGGTTTGTGGGTCCACAGACAGCTTGGCCGATGGAAACACCCAGAACCAGGCCCAGCTCTCGCCCGCCCTGGGGTACTTGCGCTCCAGTGCATGAGGCAGATACACGCCTCCGCGCCCCGTGGCACGGTCCTGCCCCCACACAGCGCGGACCTGAATCAGCTGCGCCCGCAACCGAGGTACGAGCGCCCTGGGCAGCATCACCACGCGGTCCTTGTCGCCCTTGCCGCTGCGCACAATGATCGCGTGGCGGTCGAAATCCACATCCTTGACCCGCAGGCCCAGCGCTTCGCGCAGGCGCAACCCACTGCCGTAAAGCAGGGCGGCCAACAGCGCTTCGGTGCCCGCCATGTGCGAAAGCAACGTCTGAACCTCCTGCACCGTCAGCACCACCGGAATCCGCTTGCGTTCTGGCGGCCGACCAATCTGCTGCATCCACGGCAATTCCATGCCCAGCACCTGCCGATACAAGAACAACAGCGCGTTGAGCGCCTGCCGGTGGGTGGCCGGCGCCACTTGCTTCTCGGTGGCGAGCATGGTCAGAAAACCCTCGACTTCAGCTTGCCCCATTTCGCGCGGATGTCGAAACCCACCATGGCTGCGGGCCGTCCACAACACAAATGCCTTGGCCCAGTAGACATAAGCTTTCTCGGTCTGTAGGCTGTAATGCAGGTAGCGAACCCGTTCGCGCACCTGATCGAGCAGCTTGATGGATCGGGGAGGGAACCAGTCAGGTTTGTCATTTCTGTTATACCTGTTCATGCATCCGGTATGATGCTTTACAGAATTGATTTCAAACACTTTTTTTGGGTGCCGTGCGACATTGTTTAACGACCACGGTTGTGGGTATCCGGTGTTTGGTCAGATAAACCATAAGTTAGCCACCAAGAAGGTGCCATGAAAACATTTGCCGCATATGTAATTATCGCGTGTCTTTCGAGTACGGCATTAGCTGGTTCAATTACAGAAAATACGTCTTGGAACAAAGAGTTCTCTGCCGAAGCCGTCAATGGTGTCTTCGTGCTTTGTAAAAGTAGCAGTAAATCCTGCGCTACCAATGACTTAGCTCGTGCATCAAAGGAATATCTTCCAGTATCAACATTTAAGATCCCCAGCGCAATTATCGGCCTAGAAACTGGTGTCATAAAGAATGAGCATCAGGTTTTCAAATGGGACGGAAAGCCAAGAGCCATGAAGCAATGGGAAAGAGACTTGACCTTAAGAGGGGCAATACAAGTTTCAGCTGTTCCCGTATTTCAACAAATCGCCAGAGAAGTTGGCGAAGTAAGAATGCAGAAATACCTTAAAAAATTTTCCTATGGCAACCAGAATATCAGTGGTGACATTGACAAATTCTGGTTGGAAGGCCAGCTTAGAATTTCCGCAGTTAATCAAGTGGAGTTTCTAGAGTCTCTATATTTAAATAAATTGTCAGCATCTAAAGAAAACCAGCTAATAGTAAAAGAGGCTTTGGTAACGGAGGCGGCACCTGAATATCTAGTGCATTCAAAAACTGGTTTTTCTGGTGTGGGAACTGAGTCAAATCCTGGTGTCGCATGGTGGGTTGGGTGGGTTGAGAAGGAGACAGAGGTTTACTTTTTCGCCTTTAACATGGATATAGACAACGAAAGTAAGTTGCCGCTAAGAAAATCCATTCCCACCAAAATCATGGAAAGTGAGGGCATCATTGGTGGCTAACAAGTCGCTCAAGGTCGCTCCCTGCGGTCGCTGGACAGTCCCAGTCGGCGCATGCTTCGCATTTTATGCGCCGCCTGTGCCTGCCCCTTAGCTCCAACGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAACCCTTCCATCGAGGGGGACGTCCAAGGGCTGGCGCCCTTGGCCGCCCCTCATGTCAAACGTTGAGC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Aeromonas sobria", "NCBI_taxonomy_id": "646", "NCBI_taxonomy_cvterm_id": "36957"}, "protein_sequence": {"GI": "AMB19637.1", "sequence": "MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPVSTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGDIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "OXA-368", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "37955", "model_name": "OXA-368", "model_type_id": "40292"}, "2397": {"model_id": "2397", "ARO_accession": "3003920", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "A gene that produces the protein lipid A 4\u2019-phosphatase", "model_sequences": {"sequence": {"3724": {"dna_sequence": {"fmax": "573902", "fmin": "573191", "accession": "AP009380.1", "strand": "-", "sequence": "TCAGAAGAGCAGGAAGACATAGTACTGTAGTATCTCCGTCAACTGGCGGGACATACACAGCATGGCAAAGACAAAGCCGATGAGGCTAAGTGTCCAGAGCCGAATGGAATCGCCGGCATAGACTGCCGACGGATGGGCAGGGCATGAGGCTCCCAACCAACGGGAACGTGCATACAGATAGACTTTATAAACAAAGTGTCCTACGATAAGTCCGACGGCGATACCCGGGATAATATCGGTGATGAAATGCACTCCGATATAAATACGGCTATAGATGACGAGTGCGACGACGCTCCAGATCGTCCACGTGTAGAATTTATTCCGAAAAATACGGCTCGTAAATAATGCCAGCGATATGTAGTTCGTCGTATGCCCTGAGATAAATCCGTACTTTCCTCCCCGATAGCCGTAGACCGTCTTCACATAGTCGATAAAATCAGGGTGGTGCGAAGGGCGGAATCTTGCGAAGAAAGGCTTGAAAAAAGAAGAGGAGAGTTGATCGCAGATGAGTACGCTCAATAAGACTGCTCCTACGATGAAGAGAGCTTCCTTTGTCGGTTTCTTATAAAAAAGGAAGAACAGAAACGCGATGGACATTATCACCCAAGTCCATTTGGCCGAGATCAAATAGAAAAAACCGTCCAACAAAGGATGCTGTACTCCGTTCAGAGTCAAAAAGAGGTTCCTTTCTACTTCAAGAATGTATTCCAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Porphyromonas gingivalis ATCC 33277", "NCBI_taxonomy_id": "431947", "NCBI_taxonomy_cvterm_id": "40629"}, "protein_sequence": {"GI": "BAG33043.1", "sequence": "MEYILEVERNLFLTLNGVQHPLLDGFFYLISAKWTWVIMSIAFLFFLFYKKPTKEALFIVGAVLLSVLICDQLSSSFFKPFFARFRPSHHPDFIDYVKTVYGYRGGKYGFISGHTTNYISLALFTSRIFRNKFYTWTIWSVVALVIYSRIYIGVHFITDIIPGIAVGLIVGHFVYKVYLYARSRWLGASCPAHPSAVYAGDSIRLWTLSLIGFVFAMLCMSRQLTEILQYYVFLLF"}}}}, "ARO_category": {"39418": {"category_aro_name": "polymyxin resistance gene", "category_aro_cvterm_id": "39418", "category_aro_accession": "3002984", "category_aro_description": "Genes conferring resistance to polymyxins"}, "40190": {"category_aro_name": "gene altering cell wall charge conferring antibiotic resistance", "category_aro_cvterm_id": "40190", "category_aro_accession": "3003580", "category_aro_description": "Genes involved in alteration of the cell wall overall charge, leading to antimicrobial resistance due to reduced binding"}}, "ARO_name": "pgpB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40628", "model_name": "PGN_0524", "model_type_id": "40292"}, "2395": {"model_id": "2395", "ARO_accession": "3003918", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Plasmid-borne apramycin-resistant aminocyclitol acetyltransferase gene identified from bovine MRSA.", "model_sequences": {"sequence": {"3717": {"dna_sequence": {"fmax": "3518", "fmin": "2693", "accession": "FN806789.3", "strand": "+", "sequence": "ATGAAAACCAGACTTGAACAAGTTTTAGAACGTTATCTCAACGGACGCGAGGTAGCTGTATGGGGTGTTCCGACACGCCGTTTGCTTCGTGCATTAAAACCTTTTAAATTTCATACTGCCGATCGTGTTGATCCTCAATATCATTATGTTGTTGCTGTAACCGATGACGACTTAACCGACTTTTTATCCGATGAACAGAGCAAGTCGTTTCAATACGCGAATGACTACCTTACGTTTGACGACGAGGGAGGCGAACTTCCGTTTGAACGAATGTGCTTCAATGTCCCCGTTGGCAGGCAAACGTATTTTGGAGACGGTGTCGTAGGAGCTTGCGAAAACGGGTATATCAAGAGCATCGGCCAATTTACATCGATTAACGGCACGGCAGAGATCCATGCGAACCATCAGTTAAACATGACCTTTGTAAGCGACGATATTCAAAACTTCTTCAACGAAGAAAGCATGGCTGTATTCCAAGAAAAGCTGCGAAAAGACCCGAAACACCCTTATGCTTATAGCAAAGAACCTATGACCATAGGTAGCGATGTTTATATCGGCGCACATGCATTCATCAATGCTTCCACTGTGACAAGCATCGGTGACGGTGCAATAATTGGCTCAGGGGCAGTAGTTCTGGAAAATGTTCCTCCTTTTGCTGTCGTCGTTGGTGTCCCTGCGAGAATCAAGCGTTACCGCTTCTCAAAGGAGATGATTGAAACCCTCCTTCGTGTCAAATGGTGGGACTGGAGTATAGAGGAAATTAACGAAAATGTTGATGCGCTTATATCACCTGAACTATTTATGAAAAAGTACGGGAGTTTGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"GI": "CBL58181.1", "sequence": "MKTRLEQVLERYLNGREVAVWGVPTRRLLRALKPFKFHTADRVDPQYHYVVAVTDDDLTDFLSDEQSKSFQYANDYLTFDDEGGELPFERMCFNVPVGRQTYFGDGVVGACENGYIKSIGQFTSINGTAEIHANHQLNMTFVSDDIQNFFNEESMAVFQEKLRKDPKHPYAYSKEPMTIGSDVYIGAHAFINASTVTSIGDGAIIGSGAVVLENVPPFAVVVGVPARIKRYRFSKEMIETLLRVKWWDWSIEEINENVDALISPELFMKKYGSL"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36243": {"category_aro_name": "aminoglycoside resistance gene", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Genes conferring resistance to aminoglycoside antibiotics."}}, "ARO_name": "apmA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40626", "model_name": "apmA", "model_type_id": "40292"}, "2103": {"model_id": "2103", "ARO_accession": "3001062", "model_param": {"blastp_evalue": {"param_value": "1e-130", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "SHV-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"sequence": {"3691": {"dna_sequence": {"fmax": "961", "fmin": "100", "accession": "NG_050068", "strand": "+", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTACTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACTGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTAGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATCGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"GI": "WP_063864673.1", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "SHV-3", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "37442", "model_name": "SHV-3", "model_type_id": "40292"}, "2064": {"model_id": "2064", "ARO_accession": "3001376", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "From the Lahey list of beta-lactamases. Not yet released.", "model_sequences": {"sequence": {"3690": {"dna_sequence": {"fmax": "861", "fmin": "0", "accession": "JQ034306", "strand": "+", "sequence": "ATGAGTATTCAACATTTTCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCTTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCTGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTCGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella sonnei", "NCBI_taxonomy_id": "624", "NCBI_taxonomy_cvterm_id": "36790"}, "protein_sequence": {"GI": "AFE48832.1", "sequence": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKIFESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "TEM-196", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "37776", "model_name": "TEM-196", "model_type_id": "40292"}, "2398": {"model_id": "2398", "ARO_accession": "3003158", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "From the Lahey list of beta-lactamases.", "model_sequences": {"sequence": {"3723": {"dna_sequence": {"fmax": "861", "fmin": "0", "accession": "KM998962.1", "strand": "+", "sequence": "ATGAGTATTCAACATTTTCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCTGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGACGCCTGCAACAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae", "NCBI_taxonomy_id": "485", "NCBI_taxonomy_cvterm_id": "36806"}, "protein_sequence": {"GI": "AIW68620.1", "sequence": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPATMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "TEM-220", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "39735", "model_name": "TEM-220", "model_type_id": "40292"}, "2399": {"model_id": "2399", "ARO_accession": "3003922", "model_param": {"blastp_evalue": {"param_value": "1e-130", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "RND efflux pump conferring resistance to fluoroquinolone", "model_sequences": {"sequence": {"3725": {"dna_sequence": {"fmax": "47827", "fmin": "46651", "accession": "NC_010378.1", "strand": "+", "sequence": "ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTGCGACGACAGCGTCGCACAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTCAGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAAGTGAATTACACTGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCTGGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTCGCGCAAAGCGAGGCGAACCGCACCGATAAATTAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCGCAGGCCGACATTCGCGCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGCGCCAGCCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAAAAGACGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCCAGCGATAATCAGGCGCTCCCGGTGGAGATTGGCCTGGTGGGCGAGGAGGGTTACCCCCACCAGGGCAAAGTGGATTTTCTCGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACGCCGGGGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTGATCGACGACAAAGCGGTACTGACCGATCAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCAGACGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGGGTATGCCGGTTAACGCCAAAACCGTTGCCATGACCTCCAGCGCCACCCTTAACTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"GI": "YP_001693237.1", "sequence": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "oqxA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40631", "model_name": "oqxA", "model_type_id": "40292"}}}