{"$update": {"_timestamp": "2016-11-08T01:42:40+00:00", "783": {"$update": {"model_sequences": {"$update": {"sequence": {"3746": {"dna_sequence": {"fmax": "3219", "fmin": "2406", "accession": "FN396876", "strand": "-", "sequence": "TCAGCGCAGCTTGTCGGCCATGCGGGCCGTATGAGTGATTGCGGCGCGGCTATCGGGGGCGGAATGGCTCATCACGATCATGCTGGCCTTGGGGAACGCCGCACCAAACGCGCGCGCTGACGCGGCGTAGTGCTCAGTGTCGGCATCACCGAGATTGCCGAGCGACTTGGCCTTGCTGTCCTTGATCAGGCAGCCACCAAAAGCGATGTCGGTGCCGTCGATCCCAACGGTGATATTGTCACTGGTGTGGCCGGGGCCGGGGTAAAATACCTTGAGCGGGCCAAAGTTGGGCGCGGTTGCTGGTTCGACCCAGCCATTGGCGGCGAAAGTCAGGCTGTGTTGCGCCGCAACCATCCCCTCTTGCGGGGCAAGCTGGTTCGACAACGCATTGGCATAAGTCGCAATCCCCGCCGCATGCAGCGCGTCCATACCGCCCATCTTGTCCTGATGCGCGTGAGTCACCACCGCCAGCGCGACCGGCAGGTTGATCTCCTGCTTGATCCAGTTGAGGATCTGGGCGGTCTGGTCATCGGTCCAGGCGGTATCGACCACCAGCACGCGGCCGCCATCCCTGACGATCAAACCGTTGGAAGCGACTGCCCCGAAACCCGGCATGTCGAGATAGGAAGTGTGCTGCCAGACATTCGGTGCGAGCTGGCGGAAAACCAGATCGCCAAACCGTTGGTCGCCAGTTTCCATTTGCTGGCCAATCGTCGGGCGGATTTCACCGGGCATGCACCCGCTCAGCATCAATGCAGCGGCTAATGCGGTGCTCAGCTTCGCGACCGGGTGCATAATATTGGGCAATTCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"GI": "CAZ39946.1", "sequence": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"}}}}}}}, "1340": {"$update": {"ARO_category": {"$insert": {"36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}}}}}, "453": {"$update": {"ARO_category": {"$insert": {"36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}}}}}, "_version": "1.1.2", "1607": {"$update": {"ARO_name": "Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin", "ARO_category": {"$delete": ["36520"], "$insert": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}}, "model_param": {"$insert": {"snp": {"param_type": "single resistance variant", "param_value": {"4484": "N609D", "4483": "S575T"}, "clinical": {"4484": "N609D", "4483": "S575T"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}, "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "model_type_id": "40293"}}, "2294": {"$update": {"ARO_name": "Campylobacter jejuni gyrA conferring resistance to fluoroquinolones"}}, "810": {"$update": {"model_sequences": {"$update": {"sequence": {"3735": {"dna_sequence": {"fmax": "37678", "fmin": "35680", "accession": "NC_017349.1", "strand": "-", "sequence": "TTACTGATCTATATCAAATTGAGTTTTTCCATTATCATACAAATCATCATAAACTTTTCCAGATATAGTAGCATTATAGCTGGCCATCCCTTTATTTTGAACGTCTTTAACATTAATCGCCATTAACATATTAGGATTATTTTTATTATATGAAACAAACCAACCTATTTGTCTTCCAGTTTCCCCTTGATTCATTTTTAATTCTGCTGTGCCAGATTTACCAATAATTCGGGCATAATTTTTGTATATATCATCCCTATGTGTTTTATTAACTACACGTTCCATACCATTAGTTAATATATCTATGTCTTTTTTAGGTATAATATCTTTTTTCCATATTTGAGATTTTGTTTTACGTAAAACATGAGGATTTTGTATATTTCCGTTATTTTCTAAAGCACTGTATATTGATAAAATTTGTATAGGGTTTACTAGTATCTCGCCTTGGCCATATCCTGAATCTGCTAATAATATTTCATTTTTTAAATTACTATTTGAGATTTGTGCTTTATAAAAGGGATAATCACTCGGGATATTTTCACCGATTCCCAAATCTTGCATACCTTGCTCAAATTTTTTGGCTCCTAATGCTAATGCAATGCGGGCAAAAAATATGTTGTCTGATGATTCTATTGCTTGCTTTAAATCGATATTGCCGTCTACTACTTTAAATCTTGTGATATTATAATTCCCCCATGATGCATCTTTTTGCCAACCCTTACCATAAATATCAAAATTAGTATTTTTGTCTAGTTTATTTTCTTTTAAGGCTATAATAGATGTTAATATTTTTTGGGTTGAACCTGGTGATGTAGTGATTTGAAATTTGTTGAGCAAAGGCTCTTTTTTATTGTTAGTTAATTTACGGTAGTCATTATTGCTTAATCCATTCATGAATGGATAAACATCGTACGATGGGGTACTTACCAAAGCTAAAATTTCTCCAGTTTTTGGTTGTAATGCTGTACCAGATCCATCGTCATTTTTCATATGTTTATAAATACTTTCTTGTACTCTAGCATCTATAGTTAAATGAAGATCTTTTCCGTTTTCAGCCTTTTTCTCCAATAATGTGTCTAAAGGTTTATTGTCATAAGTATTTGCAATGGATACCTTAAAACCATCAGTGTTTTGCAATTGTTTATCATAGAGGCGTTCTAAGCCTTTTTTTCCAATAACAGTATTTTTGCTATAGTTTCTAAATTGCTTACTTTTTAACTCGTCAGAATTAATTGGACCCACATAACCTAAAAGGTGTACTGTTGCTTCGTTCAATGGATAAACACGGCTTTTTATAGTGTTTATTTGTAAATTGTATGATTTAATTAATTTGTCTATATATTCATCTTGTTTATTTATCTTTTTAATTGGTACAAATGAATCTGGCTGAACCCATTTTTGATTAACTTTATTGGTTATAGCTTTTGTATCAATTTGTAAGTCACGAGCAATATCATCATATTTTTCTTTGGGTGTTTTGTTAGGGACAATACCGATTTCATATGTATTTCCAGTTTTAGCTAATTCTATACCATTTCTATCTTTTATTTTGCCTCGCTCTGATTTTAATGTTTCTATATTAATTTTCTGTCCATTTTTCAAACCAGGTACTATTACGTCTGGTCTCCAATCTAATTTCCAATGCTTATCTTCATAAATAAAGTTTAATTGTGTATTACGTCGTATAGTTCCATATTTTGTATATATGTTATATTTAACATCAACTTGCTTTTTATCTTTTCCAGTTTTTTTAATTTCATGATTAGTAATTTTTAAGTTATTGACACTTAAATCTTTGTAAATTTTTTTATTCCTATCTACAATTTCTTCTTCTCCATATGCCAGTTTAGATTTTTCTGAACTATTTTTATATACTTCGTTATAGTTTCCTTTTTCAATAGAACTAATTGTTTTCTCAATATCGTCATCTTTGAATAACCAAGTTATTATAATCATAATTAGTAAAAGAACTAGCACACTAATATAAATTTTTTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus", "NCBI_taxonomy_id": "1279", "NCBI_taxonomy_cvterm_id": "37074"}, "protein_sequence": {"GI": "WP_000725529.1", "sequence": "MKKIYISVLVLLLIMIIITWLFKDDDIEKTISSIEKGNYNEVYKNSSEKSKLAYGEEEIVDRNKKIYKDLSVNNLKITNHEIKKTGKDKKQVDVKYNIYTKYGTIRRNTQLNFIYEDKHWKLDWRPDVIVPGLKNGQKINIETLKSERGKIKDRNGIELAKTGNTYEIGIVPNKTPKEKYDDIARDLQIDTKAITNKVNQKWVQPDSFVPIKKINKQDEYIDKLIKSYNLQINTIKSRVYPLNEATVHLLGYVGPINSDELKSKQFRNYSKNTVIGKKGLERLYDKQLQNTDGFKVSIANTYDNKPLDTLLEKKAENGKDLHLTIDARVQESIYKHMKNDDGSGTALQPKTGEILALVSTPSYDVYPFMNGLSNNDYRKLTNNKKEPLLNKFQITTSPGSTQKILTSIIALKENKLDKNTNFDIYGKGWQKDASWGNYNITRFKVVDGNIDLKQAIESSDNIFFARIALALGAKKFEQGMQDLGIGENIPSDYPFYKAQISNSNLKNEILLADSGYGQGEILVNPIQILSIYSALENNGNIQNPHVLRKTKSQIWKKDIIPKKDIDILTNGMERVVNKTHRDDIYKNYARIIGKSGTAELKMNQGETGRQIGWFVSYNKNNPNMLMAINVKDVQNKGMASYNATISGKVYDDLYDNGKTQFDIDQ"}}}}}}}, "320": {"$update": {"ARO_name": "Streptococcus pneumoniae PBP2x conferring resistance to amoxicillin", "ARO_category": {"$delete": ["36520"], "$insert": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}}, "model_param": {"$insert": {"snp": {"param_type": "single resistance variant", "param_value": {"4479": "M339F", "4478": "M400T", "4473": "I371T", "4475": "N514H", "4474": "R384G", "4477": "N605T", "4476": "L546V"}, "clinical": {"4479": "M339F", "4478": "M400T", "4473": "I371T", "4475": "N514H", "4474": "R384G", "4477": "N605T", "4476": "L546V"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}, "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "model_type_id": "40293"}}, "2033": {"$update": {"ARO_category": {"$delete": ["36298"]}}}, "2403": {"$update": {"ARO_description": "Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid, a fluoroquinolone antibiotic. These mutations have also been shown to reduce susceptibility to ciprofloxacin."}}, "431": {"$update": {"ARO_name": "Escherichia coli marR mutant conferring antibiotic resistance"}}, "6": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["3588"], "$insert": {"3740": {"dna_sequence": {"fmax": "1245553", "fmin": "1244359", "accession": "NC_016845.1", "strand": "-", "sequence": "TTAAGACTTGGTTTGTTCTGATGGCGCGTTGCCTGCGGCTTGCTGTTTATCATCAGAAGCTACTTCCTGCGCTTTTACCTGCACACCTGGTTTGATTTTTTGCAGGCCGGTGACGATAACGCGATCGCCGGATTTCAGACCGTCAGTGACCAGCCATTTATCGCCGATCGCCTGAGAAGCAGTGACCTGGCGGACTTCGACTTTATCGCCTTCCCCCACTACCATGACGCTGGCGTCGCCGCGCGGCGTACGGGTAACACCCTGTTGCGGTACCAGCAGGGCGTCAGGGTTAATCCCTTCTTCCAGACGGGCACGGACGAACATCCCCGGTAGCAGGGTGTGATCCGGGTTCGGGAAAATAGCGCGTAGCGTGATTGAGCCGGTGGTCTGATCGACGGTGACATCCGAGAATTCCAGCGTGCCGGACTGCGGATACTTAAGACCGTCATTAGTCACTAGCTCCACTTTCGCTTTGCCGTTTTCCTGTTTCAGGCGGCCGTCGGCTAGCTCCTGCTTCAGGCGCAGGAAATCATTGCTCGACTGGGTGACGTCAACATAGATCGGATCCAGCTGCTGAACGGTTGCCAGGGCGGTCGTTTGACCATTCTGTACCAGCGCCCCTTCGGTCACGGTGGATTTACCAATCCGGCCGCTGATCGGCGAGGTGACTTTGGTGTAGGCCAGATTGATGCGCGCGGTTTCAACGGCCGCTTTCGCCGCGACCACGGCCGCATTGCTCTGCTGCGCCGTCGCAACGGCGGTATCGTAGTCTTGTTGACTAATATATTTGGTGCCCAACAGTTTCTGATAACGCTTGACCGTCAGTTGATCCATGTTTGCCGCCGCCTGGGCTTTTGCCAGGTCGCCTTTGGCGCTGTCATAGCTGGCCTGATAGGTGGCTGGATCGATCTGATACAGGGAGACGCCGGCCTGGATATCGCTACCTTCCACGAAGTTACGTTTTAAAATAATGCCACTGACCTGAGGACGGACTTCCGCAATGCGATAGGCGCTGGTGCGGCCTGGCAGTTCGGTGGTTATTTGTAGAGGTGCGGATTTGAGCGTCACAATACCGACTTCCGGCATGTGCTGGGCTCCCTGTTGAGCCGGTTTATCGTCACATCCTGTTAGCGCTAAGCTGCCTGAGAGCATCAGAACGACCGCCAGAGGCGTTAACCCTCTGTTTTTGTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae subsp. pneumoniae HS11286", "NCBI_taxonomy_id": "1125630", "NCBI_taxonomy_cvterm_id": "40663"}, "protein_sequence": {"GI": "YP_005225489.1", "sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS"}}}}}}}}, "2092": {"$update": {"ARO_name": "Enterobacter aerogenes acrR mutation conferring antibiotic resistance"}}, "1938": {"$update": {"ARO_category": {"$insert": {"36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}}}}}, "293": {"$update": {"model_sequences": {"$update": {"sequence": {"3768": {"dna_sequence": {"fmax": "861", "fmin": "0", "accession": "KP050487.1", "strand": "+", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCACGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGACCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"GI": "AJO16040.1", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGHVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}}}, "1035": {"$update": {"ARO_name": "Streptococcus pneumoniae PBP2b conferring resistance to amoxicillin", "model_sequences": {"$update": {"sequence": {"3737": {"dna_sequence": {"fmax": "1496273", "fmin": "1494215", "accession": "NC_003098.1", "strand": "-", "sequence": "CTAATTCATTGGATGGTATTTTTGATACAGATTGATAATGTCACGCGCAATGGAAGGTCCTACACCATTTGTTAGATTGGTATTATGAGGAAAGACCACTGCGACAGCGATTTGGGGATTATCAGATGGGGCATAGGCCACCGCATTGGTATTGGTTGCTTGCTGACCATCTGCCACATAGCTTTCGGCTGTACCTGTTTTTCCGCTAATGGATACCAAGGCACCATTTGAAAAGGCACGTCCAGTTGTCAATCCACTAGTACCATGGGCAACCTGATAAAAACCTTGGTGCAAGATGCTCATATCGGAGTCGGATATATTGACCTTATTCATCTCTGTCGGTTGCAGTTGCTGAATCAAGTCACCCAGTCCTCCCTTATCATTATTACCATAAATGCCTTCAACAATACGAGGAGCCACACGAACACCATTATTTGCAATAGTTGCTACATACTGAGCCAACTGCATCGGCGTATAGTTATCAAACTGCCCAAAGGCATTAGTAATGTAATTAGCAAAGCTATACTCTTTGGGAACAAATCCAGTAGATTCATCTGGTAGGTCAATTCCTGTCGCAGTACCCAAGCCATATTCGCCAAAGGTTGAACGCAGTTTCTCCATAGCAGACTCTAGATTGCTGGTGCCGACAAACATATTGGGTTGATAGGTTTGCCCCATAAGACCTAAGGCTGTTTGGACCATATAGGTATTTGATGAATACTCCAGAGCTTGGACCGCTGTGATAGGGAATGAACCGTAAGCCTGAGTATACCAAGAATTGATGGGAGCTGAACCTTGGAAGACAATGGACTGGTCTGTCAAGGTCTGGTTTCCTGACAAGACTCCATTTTCCCAACCTGAGCTGATGGTCGCCGCCTTGACAACCGAACCTGGAACAAAGACATTGGTTACCGTTCCCAAGGAATCAGGCGTCAACTCTCCCGTTTTCAAGTCATGTTTAATCCCTGACATAGACAAAACCGCACCTGTTTTTGGGTTAAGGGCGACTGCATAGACACCTTCAGAATACTTGGCTCCACCATTTTCTAGCTCAGAATTGAAATAACTTTTCAGTAAAGCATCCACGCTATCTTGGAAAGCCAAATCAATGGTCAGTTTGATATTGTTTCCCTTACTACCTTCCTCAATTGTATCCACGCTTTCCATATTGCCATATTTATCCAGATGGATTTCTTTTACCGAGCGTTTTCCTTGTAAGGTCTCTTCATATTGCTTTTCCAAATAGGAGGTTCCTACACGGTCATTTAGAGAATAGCCTTTTTTAAGATAGGCTTCTGCTTCTTCCGCTGGGAGACCAGCTTTTTCACTGGATACACTCCCAACTATAGAAGAAAGGGAAGTTTCCAAAACCTTTCTATCCCAAGAAGTAGAAATACTAATGCCAGGCATCTCCTTTGAAATAGAGGCAATAACAGCCACCTGAGAATCATTTAGAGGATCTGTAGCAATGGTTCCTGTCGCAAAGTTTCCAACAGCATTTAACTGACTAAAAAGATAGATTTCTTTCTTTTCATCCTCTGTATAGTTTAGTTGACTCGTTTGTACACTATCGACCGCATTGTTATACAGTTCTGATTCGGATAGACGATTGCCATCTGAATCCAAGCGTTTCTCGCTTGGGAGAGCTTCCACTATTTTTTTATAGATTTCAGGATCAGCCAAATAGTAATCCGCCAGCTGGCGTTCTGTCAAATTTGGAGAACTGATGCTCACATAAGTCAGTAACTTTTTAGCTGTTTCTTTTAAGTCTGTAGCCGTCATTTTATTGCTACGCGTAAAGGAAACAACCTGCTTTAACGTATTTTCTACCAAAGGTTTTCCACTAGCATCATAAATTTCCCCACGGGCTGAACTGCTTGTAATCTTGGTCTGACTAGCTGAGGCTAGCTTTTTTTCGTAAAAATCCTTGTTCAAAACCTGCATATACAACAAACGACCAATAATGGTCATAAAGAGTAAAATGACGATTGAAAACAATAAATTAAGCCGAATCGGAATCGAATGGCTGTTAAATTTTCTCATACAAATCAGTCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus pneumoniae R6", "NCBI_taxonomy_id": "171101", "NCBI_taxonomy_cvterm_id": "39596"}, "protein_sequence": {"GI": "NP_359110.1", "sequence": "MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN"}}}}}, "ARO_category": {"$delete": ["36520"], "$insert": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}}, "model_param": {"$insert": {"snp": {"param_type": "single resistance variant", "param_value": {"4480": "T445A", "4481": "E475G", "4482": "T488A"}, "clinical": {"4480": "T445A", "4481": "E475G", "4482": "T488A"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}, "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "model_type_id": "40293"}}}, "$delete": ["259"], "$insert": {"2433": {"model_id": "2433", "ARO_accession": "3003967", "ARO_description": "lfrA is involved in the active efflux of quinolones and is found in Mycobacterium smegmatis.", "model_sequences": {"sequence": {"3766": {"dna_sequence": {"fmax": "1685", "fmin": "170", "accession": "U40487.1", "strand": "+", "sequence": "ATGTCCACCTGCATCGAGGGCACGCCGTCGACGACCAGGACGCCCACGCGCGCCTGGGTGGCGCTGGCCGTCCTCGCACTTCCGGTGCTGCTCATCGCGATCGACAACACCGTGCTGGCGTTCGCGTTGCCGCTGATCGCCGAGGACTTCCGCCCGTCGGCCACCACGCAGCTGTGGATCGTCGACGTGTACTCACTGGTGCTGGCCGCGCTGCTGGTCGCCATGGGCAGCCTCGGCGACCGACTGGGCCGCCGCAGGGTGCTGCTCATCGGCGGGGCCGGGTTCGCGGTGGTCTCGGCGCTGGCGGCCTTCGCCCCGAGCACCGAGTTGCTGGTGGGAGCGCGCGCACTTCTCGGTGTGTTCGGCGCGATGCTGATGCCTTCGACGCTGTCGTTGATCCGCAACATCTTCACCGACGCGTCGGCGCGGCGGTTGGCCATCGCGATCTGGGCGTCGTGTTTCACCGCGGGTTCCGCGCTGGGCCCGATCGTCGGCGGCGCGCTGCTGGAGCATTTCCACTGGGGCGCAGTGTTCCTGGTGGCGGTGCCGATCCTGTTGCCGCTGCTGGTCCTCGGCCCGCGTCTGGTGCCCGAATCGCGTGATCCCAATCCGGGCCCGTTCGATCCCGTGAGCATCGTGCTGTCGTTCACGACCATGCTGCCCATCGTGTGGGCGGTCAAAACCGCGGCGCACGACGGTCTGTCGGCGGCGGCCGCGGCCGCGTTCGCCGTGGGCATCGTCTCGGGTGCGTTGTTCGTGCGACGGCAGAACCGCAGTGCCACACCGATGCTCGACATCGGCCTGTTCAAGGTCATGCCGTTCACGTCGTCGATCCTGGCGAACTTCCTGTCGATCATCGGCCTGATCGGGTTCATCTTCTTCATCTCGCAGCACCTTCAGTTGGTGCTGGGCCTGTCCCCGCTCACCGCCGGCCTGGTGACGCTGCCGGGTGCCGTGGTGTCGATGATCGCGGGCCTGGCCGTGGTGAAGGCCGCCAAGCGCTTCGCACCCGACACCCTGATGGTCACGGGCCTGGTGTTCGTGGCGGTCGGGTTCCTGATGATCCTGTTGTTCCGCCACAACCTCACGGTGGCCGCGATCATCGCGTCGTTCGTGGTGCTCGAGCTCGGCGTCGGCGTCTCGCAGACCGTGTCCAACGACACCATCGTGGCGTCGGTTCCCGCCGCGAAATCCGGTGCGGCGTCCGCGGTTTCCGAGACGGCCTACGAGCTGGGCGCCGTGGTGGGGACAGCGACGCTGGGCACGATCTTCACGGCGTTCTACCGCAGCAACGTCGACGTGCCCGCGGGGCTGACGCCCGAGCAGACCGGTGCGGCGGCCGAGAGCATCGGCGGTGCGGCCGCGGTGGCAGCGGATCTGCCTGCCGCCACCGCCACGCAGCTTCTCGATTCGGCCCGTGCGGCGTTCGATTCGGGTATCGCCCCGACCGCGGTGATCGCCGCGATGCTGGTGCTGGCCGCCGCCGCGGTGGTGGGTGTGGCGTTCAGGCGCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium smegmatis str. MC2 155", "NCBI_taxonomy_id": "246196", "NCBI_taxonomy_cvterm_id": "36769"}, "protein_sequence": {"GI": "AAC43550.1", "sequence": "MSTCIEGTPSTTRTPTRAWVALAVLALPVLLIAIDNTVLAFALPLIAEDFRPSATTQLWIVDVYSLVLAALLVAMGSLGDRLGRRRVLLIGGAGFAVVSALAAFAPSTELLVGARALLGVFGAMLMPSTLSLIRNIFTDASARRLAIAIWASCFTAGSALGPIVGGALLEHFHWGAVFLVAVPILLPLLVLGPRLVPESRDPNPGPFDPVSIVLSFTTMLPIVWAVKTAAHDGLSAAAAAAFAVGIVSGALFVRRQNRSATPMLDIGLFKVMPFTSSILANFLSIIGLIGFIFFISQHLQLVLGLSPLTAGLVTLPGAVVSMIAGLAVVKAAKRFAPDTLMVTGLVFVAVGFLMILLFRHNLTVAAIIASFVVLELGVGVSQTVSNDTIVASVPAAKSGAASAVSETAYELGAVVGTATLGTIFTAFYRSNVDVPAGLTPEQTGAAAESIGGAAAVAADLPAATATQLLDSARAAFDSGIAPTAVIAAMLVLAAAAVVGVAFRR"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "lrfA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40738", "model_name": "lrfA", "model_type_id": "40292"}, "2432": {"model_id": "2432", "ARO_accession": "3003966", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Klebsiella outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK35 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism.", "model_sequences": {"sequence": {"3763": {"dna_sequence": {"fmax": "1904991", "fmin": "1904307", "accession": "NC_016845.1", "strand": "-", "sequence": "TTAGAACTGGTAAACGATACCCACGGCCGCCTGGTCGTCAGTGGCGACACCAGCCGCTTTGGTGTAATCGTTGTCGTCCAGCTGGTTGAATTTATACGCAGCGTAGACGTTCATGTTCTTGTTAAAGTAGTACCAGGTACCCACTTCGATGTATTTAACCAGATCCGCATCGCCGCCGGAGAAGCCAGCACGCGACTGCAGGTCCTTGCCTTTGGTCTGTACGTAGCCGATGGACGGACGCAGGCCGAAGTCAAACTGATACTGTACAACTGCTTCAAAGTTCTGAGTTTTACCAGCGAAGTGGTTATCTTCTTCCGGAGTCATGTTGTAAGTCTGGGAGTACATGACGGCCGCATAGATGTTGTTAGCGTCATATTTTGCAGAGGTCGCCCAGGCTTCGGCTTTGTCGCCATTGCCGTCAGCTTTCTGATCGACGCTACGGTTAGAGCTGGAGTAGCCTGCAGACAGTGCGATACCGTTGTCGAACGCGTAGGTGGCTGCGGTGCTGAAGCCGTCGCCATTCTGCTTGCGAATCGCACGGTCATGGTCGTTTTTACCCTGGTACTGCAGCGCGAAGCTCAGACCGTCAACCAGACCGAAGAAGTCGGAGTTACGGTAGGTTGCGACGCCGTTGGTACGACCGGTCATGTAGTTGTCGGTATAGTTCCAGCCGTCACCGCCCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae subsp. pneumoniae HS11286", "NCBI_taxonomy_id": "1125630", "NCBI_taxonomy_cvterm_id": "40663"}, "protein_sequence": {"GI": "YP_005226137.1", "sequence": "MGGDGWNYTDNYMTGRTNGVATYRNSDFFGLVDGLSFALQYQGKNDHDRAIRKQNGDGFSTAATYAFDNGIALSAGYSSSNRSVDQKADGNGDKAEAWATSAKYDANNIYAAVMYSQTYNMTPEEDNHFAGKTQNFEAVVQYQFDFGLRPSIGYVQTKGKDLQSRAGFSGGDADLVKYIEVGTWYYFNKNMNVYAAYKFNQLDDNDYTKAAGVATDDQAAVGIVYQF"}}}}, "ARO_category": {"36409": {"category_aro_name": "gene modulating permeability to antibiotic", "category_aro_cvterm_id": "36409", "category_aro_accession": "3000270", "category_aro_description": "Genes directly or indirectly reducing overall permeability to antibiotics."}, "40439": {"category_aro_name": "gene conferring resistance via absence", "category_aro_cvterm_id": "40439", "category_aro_accession": "3003768", "category_aro_description": "Deletion of gene or gene product results in resistance. For example, deletion of a porin gene blocks drug from entering the cell."}}, "ARO_name": "Klebsiella OmpK35 conferring resistance to beta-lactam", "model_type": "protein knockout model", "model_description": "A model to detect cases where the absence of a protein due to large scale insertions or deletions confers elevated resistance to antibiotic(s). These models include reference sequences and a curated BLASTP cut-off.", "ARO_id": "40737", "model_name": "Klebsiella OmpK35 conferring resistance to beta-lactam", "model_type_id": "40354"}, "2431": {"model_id": "2431", "ARO_accession": "3003965", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "hp1184 is a translocase that belongs to the MATE efflux pump family. It is found in H. pylori and is involved in the active efflux of antibiotics.", "model_sequences": {"sequence": {"3762": {"dna_sequence": {"fmax": "1254164", "fmin": "1252784", "accession": "NC_000915.1", "strand": "-", "sequence": "TTAAGTTTTCAAAGCGATAGGGTTTTTCTCTTTATAAGTGGTAAAAACCCCTTTTTTGATTTCGTAATAAGTTACCCCTAACGCTACTAAAAACGCTAAAAATTGCGCAATGGGGTAAGTTACCCAAACGCCATTAATCCCATAGAAATGACTTAAAATCGGCAATAGAATAACGATAAACCCCAGCGTGTGTGAAAGGGTGATGATAAACGAACTTTTGGTGCGTTGGATGGATTGGAAAAACACCGCGCACAACAAAGTCATGCCTAAGAAAATATAGCCCACATAATAAATATTCATCGCCCTTTTAGTCTCTTGCATAAAAAGGGGGTCTTGTTCGCTTGGCTGCAAATAAAGCTTGATTAAAAATTCATCTAAAAAATAATAAGCGCCATAGAAAACAATCCCTATACAAAACGCTGCTTTCAAACCAAAGACAAACACCTCTTTCACGCGCTCTAAATTTCTAGCCCCATAGCTAAAGCTCGCAATCGGTTGGATGCCTTGAGAAATCGCAAACAAAGTCGTAAAAAAGATAATCGCATTATACATAACGATCCCATACATGCTTACAAACCTTTCCCCAGCCGTGTGCATGATAGCGGTATTAAACAACAAAATCATAACAGAAGCACTAAATTCTGCCGTGCTTTGAGGCACGCCGCTTTTAGCTGAAGAAATGACTGAAGACAAGGAAAATCGTTTGATGAAATACAATTGCCCTTTTTTGCGCCAAAAATGCTGCATTAAGACTAAAACCCCTATCGCATGCCCTATCACGGTGGCTATCGCGCTGCCTTGAACCCCCACTTTTAAAACAAAAATAAACAAGTAGTTGAAAAAGATATTCGCTAACGAGCCAATCAGCATCGCTACCATCGCTAAAATGGGGCGTTTGTCATTCACCACAAAAACATCCGCCAAAGGGTGCAAAACCATAAAAACCGCGCCCATTAAAATGATTTCAATGTAGCGTTTGGACATGCTCAATAAAGCGTCATTGCTCCCAAAAAAACGCGCGATAGTTTCGCTAAAAGGCAATAACGCCATGCTCAAAATAAAGGCACTTATAGCGACAAAATAAAACACGCTGCTAAACACAAGCCTAGCCCTATGGGTTTTATTTTGACCCAAAAAATACCCCACAATACTCGCTGCCCCAAAACCAAAAAGCAATTCATACGCAATGAGCCCTGGAAAAATAGGCCATGCGATATTGACTGCAGCGATAGCTTCTTTACCCAGTTTCTTGCCCACAAACATGCCATCTATCATAGAGTAAGTGGAAAGTGAAATCATAGAAAAAGCTAAAGGGATAAAATAATAAAAAAAGAGCTTTCTTATCGGATCTTTATGCAAATCAATCTTTTTTATTAGCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori 26695", "NCBI_taxonomy_id": "85962", "NCBI_taxonomy_cvterm_id": "36758"}, "protein_sequence": {"GI": "NP_207975.1", "sequence": "MLIKKIDLHKDPIRKLFFYYFIPLAFSMISLSTYSMIDGMFVGKKLGKEAIAAVNIAWPIFPGLIAYELLFGFGAASIVGYFLGQNKTHRARLVFSSVFYFVAISAFILSMALLPFSETIARFFGSNDALLSMSKRYIEIILMGAVFMVLHPLADVFVVNDKRPILAMVAMLIGSLANIFFNYLFIFVLKVGVQGSAIATVIGHAIGVLVLMQHFWRKKGQLYFIKRFSLSSVISSAKSGVPQSTAEFSASVMILLFNTAIMHTAGERFVSMYGIVMYNAIIFFTTLFAISQGIQPIASFSYGARNLERVKEVFVFGLKAAFCIGIVFYGAYYFLDEFLIKLYLQPSEQDPLFMQETKRAMNIYYVGYIFLGMTLLCAVFFQSIQRTKSSFIITLSHTLGFIVILLPILSHFYGINGVWVTYPIAQFLAFLVALGVTYYEIKKGVFTTYKEKNPIALKT"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "hp1184", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40736", "model_name": "hp1184", "model_type_id": "40292"}, "2430": {"model_id": "2430", "ARO_accession": "3003964", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "hp1181 is a translocase that is part of the MFS efflux pump family. It is found in H. pylori and has role in the active efflux of antibiotics.", "model_sequences": {"sequence": {"3761": {"dna_sequence": {"fmax": "1250819", "fmin": "1249487", "accession": "NC_000915.1", "strand": "+", "sequence": "ATGTTTAAGAAAATTTTTCCATTAGCGTTAGTGTCATCGTTGCGGTTTTTGGGGCTTTTTATTGTTTTGCCGGTCATTAGTTTGTATGCGGATAGTTTCCATTCAAGCAGTCCCTTACTCGTGGGGTTGGCTGTGGGCGGAGCGTATCTTACGCAAATTGTTTTTCAAACCCCCATGGGCATTCTTAGCGATAAGATAGGCCGTAAAGTGGTGGTTATGGTGTGCTTGCTGTTGTTTTTAGCCGGCTCGTTAGTGTGCTTTATAGCGAATGATATTGTTTGGCTCGTTATAGGGCGCTTCATTCAAGGCATGGGGGCTTTAGGGGGGGTTATTAGTGCGATGGTGGCGGATGAAGTGAAAGAAGAAGAGCGCACCAAAGCCATGGCCATCATGGGAGCGTTTATTTTCATTAGCTTCACTATAAGCATGGCGATTGGCCCTGGGGTTGTAGCGTTTTTGGGGGGGGCAAAATGGCTCTTTTTACTCACGGCGATCTTAACTTTATTGAGTTTATTGATGCTTTTAAAAGTCAAAGACGCCCCTAAAATTTCTTACCAGATCAAAAACATAAAAGCTTACCAACCCAACTCTAAAGCCTTGTATCTTTTGTATCTAAGCTCTTTTTTTGAAAAAGCGTTCATGACGCTTATTTTTGTGCTGATCCCTTTAGCCTTAGTGAATGAATTTCATAAAGATGAAAGCTTTTTAATCTTGGTGTATGTGCCTGGAGCCTTATTAGGGGTCTTAAGCATGGGAATAGCGAGCGTTATGGCTGAAAAATACAACAAGCCTAAAGGAGTGATGCTTTCTGGCGTATTATTGTTTATTGTGAGTTATTTGTGCTTGTTTTTAGCCGACTCTAGCTTTTTAGGGAAATATTTATGGCTTTTTATTGTTGGGGTGGCGTTTTTCTTTATTGGTTTTGCCACCTTAGAGCCTATCATGCAATCTTTAGCGTCTAAATTCGCCAAAGTGCATGAAAAAGGCAAGGTTTTAGGGCAATTCACTACTTTTGGCTATTTAGGGAGCTTTGTTGGGGGCGTGAGCGGGGGGTTGAGCTACCATCATTTAGGCGTTTCTAACACAAGCTTGATCGTTGTAGCTTTAGGGCTTATTTGGGGGCTATCGCTCTTTTTACTCAACAACCCTTCCAAGCAAAAAAATGTCTATTTCCCCTTAGACGCTTACAATGAGGAACAATTTGAAACTTTAGAGGATAAAATCATTGAATGGTATGTTAATATTAGCGAAGAAATCATTATTGTGAAATATAATTCCGATCACATTAGCGAAGAAGAAATCATTCACTTAGCGCAAAACTTTAGAAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori 26695", "NCBI_taxonomy_id": "85962", "NCBI_taxonomy_cvterm_id": "36758"}, "protein_sequence": {"GI": "NP_207972.1", "sequence": "MFKKIFPLALVSSLRFLGLFIVLPVISLYADSFHSSSPLLVGLAVGGAYLTQIVFQTPMGILSDKIGRKVVVMVCLLLFLAGSLVCFIANDIVWLVIGRFIQGMGALGGVISAMVADEVKEEERTKAMAIMGAFIFISFTISMAIGPGVVAFLGGAKWLFLLTAILTLLSLLMLLKVKDAPKISYQIKNIKAYQPNSKALYLLYLSSFFEKAFMTLIFVLIPLALVNEFHKDESFLILVYVPGALLGVLSMGIASVMAEKYNKPKGVMLSGVLLFIVSYLCLFLADSSFLGKYLWLFIVGVAFFFIGFATLEPIMQSLASKFAKVHEKGKVLGQFTTFGYLGSFVGGVSGGLSYHHLGVSNTSLIVVALGLIWGLSLFLLNNPSKQKNVYFPLDAYNEEQFETLEDKIIEWYVNISEEIIIVKYNSDHISEEEIIHLAQNFRK"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "hp1181", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40735", "model_name": "hp1181", "model_type_id": "40292"}, "2436": {"model_id": "2436", "ARO_accession": "3003970", "model_param": {"snp": {"param_type": "single resistance variant", "param_value": {"4527": "D295G", "4526": "V241D", "4525": "G99R", "4524": "E13G", "4528": "P313L"}, "clinical": {"4527": "D295G", "4526": "V241D", "4525": "G99R", "4524": "E13G", "4528": "P313L"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Non-van ligases that synthesize D-Ala-D-Ala, the default cell wall precursor that makes a cell vulnerable to glycopeptide antibiotics. Mutations in the ddl gene can cause the production of nonfunctional/inactivated D-Ala-D-Ala ligases, which can render bacteria glycopeptide dependent depending on the presence of vancomycin resistance clusters.", "model_sequences": {"sequence": {"3769": {"dna_sequence": {"fmax": "1109", "fmin": "53", "accession": "AY168442.1", "strand": "+", "sequence": "TTGAAAATTATTTTATTATATGGCGGACGCAGTGCAGAGCATGATGTATCGCTTCTATCCGCTTTTTCAGTAGTCAATGCTGTATATTATAATTACTACCAAGTACAATTAGTAATGATCACGAGAGATGGCCAGTGGCTAAAAGGCTCTTTATTGACTGAAGCCCCTACATCCAAAGAAGTGTTGAATCTGACGGATTCGGCTTACCAAGGGACGCCGATCCAACCTGGTGAGATCAAGGAAGAGGATGCGATTGTTTTTCCGCTGCTCCACGGACCAAATGGAGAAGATGGAACGATCCAAGGTTTTCTAGAGACCATCGGCATGCCTTATGTAGGCGCAGGGGTTTTAACTAGTGCCTGTGGCATGGATAAGATTATGACCAAATATATCTTGCAGGCGGCGGGGATTCCGCAAGTTCCTTATGTACCCGTTCTTAAAAACTATTGGAAAGAAAATCCTAAAAAAGTATTTGAACAATGTGAAGGCAGTCTTTTGTATCCAATGTTTATCAAACCTGCCAATATGGGTTCAAGTGTTGGGATCACAAAAGCTGAAAATCGGGAAGAATTGCAAAATGCACTTCAAGAAGCCTACCGTTATGATACACGAGCGATCGTAGAACAAGGGATCGAAGCTCGCGAAATCGAAGTCGCTGTTCTTGGAAATGAAGATGTGCGTACAACAATGCCCGGCGAGATCGTTAAAGATGTAGCTTTTTATGATTACAATTCGAAGTATCTTGACAATAAGATTGAGATGCAGATCCCAGCTCAAATTCCTGAGGAGACACAAGCGAAAGCGCAAGAGTTTGCCAAAAAAGCTTATACGATGCTTGGAGGAAGCGGCCTCAGCCGCTGCGACTTTTTCTTGACGAACAAAAACGAATTATTCCTGAATGAATTGAACACGATGCCTGGTTTTACCGAGTTTAGTATGTACCCGCTGTTGTGGGAAAAAACCGGTCTGCCATATGGTGATTTGATTGAGGAATTGATTCAATTAGGAGTCAACCGTTTTAAACAGCGTCAAGCCTTTTTAACCGATGTCGAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus gallinarum", "NCBI_taxonomy_id": "1353", "NCBI_taxonomy_cvterm_id": "36781"}, "protein_sequence": {"GI": "AAN62561.1", "sequence": "MKIILLYGGRSAEHDVSLLSAFSVVNAVYYNYYQVQLVMITRDGQWLKGSLLTEAPTSKEVLNLTDSAYQGTPIQPGEIKEEDAIVFPLLHGPNGEDGTIQGFLETIGMPYVGAGVLTSACGMDKIMTKYILQAAGIPQVPYVPVLKNYWKENPKKVFEQCEGSLLYPMFIKPANMGSSVGITKAENREELQNALQEAYRYDTRAIVEQGIEAREIEVAVLGNEDVRTTMPGEIVKDVAFYDYNSKYLDNKIEMQIPAQIPEETQAKAQEFAKKAYTMLGGSGLSRCDFFLTNKNELFLNELNTMPGFTEFSMYPLLWEKTGLPYGDLIEELIQLGVNRFKQRQAFLTDVE"}}}}, "ARO_category": {"36633": {"category_aro_name": "glycopeptide resistance gene", "category_aro_cvterm_id": "36633", "category_aro_accession": "3000494", "category_aro_description": "Genes conferring resistance to glycopeptides."}, "36021": {"category_aro_name": "gene conferring antibiotic resistance via molecular bypass", "category_aro_cvterm_id": "36021", "category_aro_accession": "3000012", "category_aro_description": "Genes involved in restructuring of the cell wall"}}, "ARO_name": "D-Ala-D-Ala ligase", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40743", "model_name": "D-Ala-D-Ala ligase", "model_type_id": "40293"}, "2435": {"model_id": "2435", "ARO_accession": "3003969", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "lmrP is a proton motive force-dependent drug transporter that is part of the MFS efflux pump family.", "model_sequences": {"sequence": {"3767": {"dna_sequence": {"fmax": "1770310", "fmin": "1769089", "accession": "CP000259.1", "strand": "-", "sequence": "CTACACCTTTTTCATTTTTGCAGAAACAACCGTAAAATAAATCCCTAGCAAAGCAATGACTACAAATAAGCATTGCACACCTAAAGGACCTGTAAAATGGCTGACAGATACTAGTAGACTAGCCAAAATAGCACCTAGGGGTTGTGCCATTGACACAAAACCTGTATAAGATCCTATTTGGGAATGATCCATCATATCAGCACGTAGGACTTGACTAGCAGGAACATTTATCATTTCCCCAAAAGTTAACAAAACAACTGATAGCCAAATAGCATAGAACTGCGTAAAGGTAAATGCCAAGAGCATCCCTAGAGTAAATAGTAAAGAACCAACCACAAGCTGAGGTAATAGTTTCCATTTTTCCGTTAATTTATTTACTACTGTCATGAAAAGGACAATCAGCAATGTATTAGTTAAAACCATTAATGATAACATTTTAGAACTAGTTACTTGGAAACCTAACACAGCCGTTGGCTGAAAATACAGTTTCAAATGGACTGGCACATAGTTATCCATCTGCATCCAGATACTACCAGAAAAGATGGCACCTAAGGTAAACAAGACAAAGGCACGATCCTGAAACACCTGACGGTAGTTCTGAAAACTCGCCAGTAATCCTTTACCATGATCAAAAGCGTGTGTTTCTGGTCTAGTCTCATCAAAATAGTAGTAAGCAACGCCAAAACAAAGTACATTAACGAGTAATAAGGCTACTAACAAGGCTAAAAAATGATGGTCATAAAAAAGCCCAGATAGCCCTGCACCAAACATGACGGCAATATTGATAAACCAATAATTGATGGTGTAAACAAATCGACGATTACTCTCATCAGTCAAATCAATCAACATAGCTTCATAGGCAGGACCATAAAAACTAGAAGCAATCTCTACCAATAAAATACCCGCAAAGGTTAACCAAGGAATAGCTGCATTAGGCAAATTAGCTAAAATAGTCAGAAACCAGCCTAGCGTTGTTCCTACTGACCCAATCATAATGACTTTTTTACGACCAAGAGCATCTGACAGATGCCCACCGTATAAAGTTCCAACAAATCCCATCAAACTGGTAATCATCATTAAGAGGCCTGTCCAAAACGTACCAAAGTAAGTCGTATAATACATGGCCATAAAGGGAAAGATACTACTGCCTAAGGTAATGGTCACAAAGCGTACCAGTTGCCTCAGCTGAATCTGCTTAGGAAGGTTTAAAAACTCTTGCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus pyogenes MGAS9429", "NCBI_taxonomy_id": "370551", "NCBI_taxonomy_cvterm_id": "40741"}, "protein_sequence": {"GI": "ABF33001.1", "sequence": "MQEFLNLPKQIQLRQLVRFVTITLGSSIFPFMAMYYTTYFGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANLPNAAIPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLLVNVLCFGVAYYYFDETRPETHAFDHGKGLLASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKLYFQPTAVLGFQVTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQVLRADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVSHFTGPLGVQCLFVVIALLGIYFTVVSAKMKKV"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "lmrP", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40740", "model_name": "lmrP", "model_type_id": "40292"}, "2434": {"model_id": "2434", "ARO_accession": "3003968", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Klebsiella outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism.", "model_sequences": {"sequence": {"3765": {"dna_sequence": {"fmax": "3728985", "fmin": "3727881", "accession": "NC_016845.1", "strand": "-", "sequence": "TTAGAACTGGTAAACCAGGCCCAGTGCAACCACGTCGTCGGTAGAGATACCGGCGTTGTGGGTGAAGCTATTGTCGTCCAGCAGGTTGATTTTGTAGTCAACATAGGTGGACATGTTTTTGTTGAAGTAGTAGGTCGCGCCAACGTCAACATATTTCAGGATGTCCTGGTCGCCGTAGCCTTCCAGATCCTTACCTTTAGACTGCAGGTAAGCCACGGACGGACGCAGACCGAAGTCGAACTGGTACTGAGCAACCACTTCGAAGTTCTGCGCTTTGTTAGCAAAGCCCAGGGAACCGGCGCGGGTCGCGTTGTAGGTCTGGGTGTACTGAGTGGCCAGGTAGATGTTGTTCGCGTCGTATTTCAGACCGCCGGTGTAGGTTTCAGCGTTGTCGCCACGACCCAGTGCCAGCTTGCTGTTCTGGTCGCCAAGACGTTTGGAGTTAGAGTATGCGAAACCAGCGCTGATGCCATCATAGATGTCATAGGTCAGAGAAGTACCGTAACCGTCGCCGTTCTGTTTCAAGGCGGTACGACCGTTGTTGGTAGGAGACAGAGCGCCTTCGCCGCTGACGCTGCCGTTTTTACCCTGATACTGCAGAGCAAAGTTCAGGCCGTCAACCAGACCGAAGAAATCAGAGTTACGGTAGGTTGCAACGCCGTTAGCACGGGACTGCAGGAAGTTGTCAGAACCGTAGGTGTCGCCGCCGAATTCCGGCAGAACGTCGGTCCAGGACGTTACGTCGTATACTACGCCGTAGTTACGACCGTAGTCGAAAGAGCCCGCGTCGCCAAATTTCAGGCCTGCGAATGCCAGACGAGTCCATGCCTGATCGCTGGAGCTTTCAGTGTTGTTCGCCTGAACGTTGTATTCCCACTGGCCGTAACCGGTCAGCTGGTCGTTGATCTGGGTTTCGCCTTTCACGCCTACACGCATGTAGGTCTGGTCGCCGTCGACGCTCTTGTCGTCAGAGAAGTAGTGCAGACCGTCAATTTTACCGTACAGGTCTAATTTGTTGCCGTCTTTGTTATAAATTTCAGCCGCATTTGCTGCGCCTGCTACCAGCAGAGCCGGTACCAGGAGGGACAGTACTTTAACTTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae subsp. pneumoniae HS11286", "NCBI_taxonomy_id": "1125630", "NCBI_taxonomy_cvterm_id": "40663"}, "protein_sequence": {"GI": "YP_005228001.1", "sequence": "MKVKVLSLLVPALLVAGAANAAEIYNKDGNKLDLYGKIDGLHYFSDDKSVDGDQTYMRVGVKGETQINDQLTGYGQWEYNVQANNTESSSDQAWTRLAFAGLKFGDAGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYGSDNFLQSRANGVATYRNSDFFGLVDGLNFALQYQGKNGSVSGEGALSPTNNGRTALKQNGDGYGTSLTYDIYDGISAGFAYSNSKRLGDQNSKLALGRGDNAETYTGGLKYDANNIYLATQYTQTYNATRAGSLGFANKAQNFEVVAQYQFDFGLRPSVAYLQSKGKDLEGYGDQDILKYVDVGATYYFNKNMSTYVDYKINLLDDNSFTHNAGISTDDVVALGLVYQF"}}}}, "ARO_category": {"36409": {"category_aro_name": "gene modulating permeability to antibiotic", "category_aro_cvterm_id": "36409", "category_aro_accession": "3000270", "category_aro_description": "Genes directly or indirectly reducing overall permeability to antibiotics."}, "40439": {"category_aro_name": "gene conferring resistance via absence", "category_aro_cvterm_id": "40439", "category_aro_accession": "3003768", "category_aro_description": "Deletion of gene or gene product results in resistance. For example, deletion of a porin gene blocks drug from entering the cell."}}, "ARO_name": "Klebsiella OmpK36 conferring resistance to beta-lactam", "model_type": "protein knockout model", "model_description": "A model to detect cases where the absence of a protein due to large scale insertions or deletions confers elevated resistance to antibiotic(s). These models include reference sequences and a curated BLASTP cut-off.", "ARO_id": "40739", "model_name": "Klebsiella OmpK36 conferring resistance to beta-lactam", "model_type_id": "40354"}, "2409": {"model_id": "2409", "ARO_accession": "3003937", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_value": {"4469": "V316T", "4466": "F504L", "4468": "I312M", "4467": "A510V", "4471": "G545S", "4470": "N512Y", "4464": "G482S", "4472": "A501P"}, "param_type_id": "36301", "param_type": "single resistance variant", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s).", "experimental": {"4469": "V316T", "4466": "F504L", "4468": "I312M", "4467": "A510V", "4471": "G545S", "4470": "N512Y", "4464": "G482S", "4472": "A501P"}}}, "ARO_description": "Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2, thereby conferring resistance to beta-lactam.", "model_sequences": {"sequence": {"3738": {"dna_sequence": {"fmax": "421574", "fmin": "419828", "accession": "NC_003112.2", "strand": "+", "sequence": "ATGTTGATTAAGAGCGAATATAAGCCTCGGATGCTGCCCAAAGAAGAGCAGGTCAAAAAGCCGATGACCAGTAACGGACGGATCAGCTTCGTCCTGATGGCAATAGCGGTCTTGTTTGCCGGTCTGATTGCTCGCGGACTGTATCTGCAGACGGTAACGTATAACTTTTTGAAAGAACAGGGCGACAACCGGATTGTGCGGACTCAAACATTGCCGGCTACACGCGGTACGGTTTCGGACCGGAACGGTGCGGTTTTGGCGTTGAGTGCGCCGACGGAGTCCCTGTTTGCCGTGCCTAAAGAGATGAAGGAAATGCCGTCTGCCGCACAATTGGAACGCCTGTCCGAGCTTGTCGATGTGCCGGTTGATGTTTTGAGGAACAAGCTCGAACAGAAAGGCAAGTCGTTTATCTGGATTAAGCGGCAGCTCGATCCCAAGGTTGCCGAAGAGGTCAAAGCCTTGGGTTTGGAAAACTTTGTATTTGAAAAAGAATTAAAACGCCATTACCCGATGGGCAACCTGTTTGCACACGTCATCGGATTTACCGATATTGACGGCAAAGGTCAGGAAGGTTTGGAACTTTCGCTTGAAGACAGCCTGCATGGCGAAGACGGCGCGGAAGTCGTTTTGCGGGACCGGCAGGGCAATATTGTGGACAGCTTGGACTCCCCGCGCAATAAAGCCCCGAAAAACGGCAAAGACATCATCCTTTCCCTCGATCAGAGGATTCAGACCTTGGCCTATGAAGAGTTGAACAAGGCGGTCGAATACCATCAGGCAAAAGCCGGAACGGTGGTGGTTTTGGATGCCCGCACGGGGGAAATCCTCGCCTTGGCCAATACGCCCGCCTACGATCCCAACAGGCCCGGCCGGGCAGACAGCGAACAGCGGCGCAACCGTGCCGTAACCGATATGATCGAACCCGGTTCGGCAATCAAACCGTTTGTGATTGCGAAGGCATTGGATGCGGGCAAAACCGATTTGAACGAACGGCTGAATACGCAGCCTTATAAAATCGGACCGTCTCCCGTGCGCGATACCCATGTTTACCCCTCTTTGGATGTGCGCGGCATCATGCAGAAATCGTCCAACGTCGGCACAAGCAAACTGTCTGCGCGTTTCGGTGCCGAAGAAATGTATGACTTCTATCATGAGTTGGGCATCGGTGTGCGTATGCACTCGGGCTTTCCGGGCGAAACTGCAGGTTTGTTGAGAAATTGGCGCAGGTGGCGGCCTATCGAACAGGCGACGATGTCTTTCGGTTACGGCCTGCAATTGAGCCTGCTGCAATTGGCGCGCGCCTATACCGCACTGACGCACGACGGCGTTTTACTGCCGGTCAGCTTTGAAAAACAGGCGGTTGCGCCGCAAGGCAAACGCATATTCAAAGAATCGACCGCGCGCGAGGTACGCAATCTGATGGTTTCCGTAACCGAGCCGGGCGGCACCGGTACGGCGGGTGCGGTGGACGGTTTCGATGTCGGCGCGAAAACCGGCACGGCGCGCAAGTTCGTCAACGGGCGTTATGCCGACAACAAACACATCGCTACCTTTATCGGTTTTGCCCCCGCCAAAAATCCCCGTGTGATTGTGGCGGTAACCATTGACGAACCGACTGCCCACGGTTATTACGGCGGCGTAGTGGCAGGGCCGCCCTTCAAAAAAATTATGGGCGGCAGCCTGAACATCTTGGGCATTTCCCCGACCAAGCCACTGACCGCCGCAGCCGTCAAAACACCGTCTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria meningitidis MC58", "NCBI_taxonomy_id": "122586", "NCBI_taxonomy_cvterm_id": "39597"}, "protein_sequence": {"GI": "NP_273462.1", "sequence": "MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAIAVLFAGLIARGLYLQTVTYNFLKEQGDNRIVRTQTLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLERLSELVDVPVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSLDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLARAYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHIATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36268": {"category_aro_name": "beta-lactam resistance gene", "category_aro_cvterm_id": "36268", "category_aro_accession": "3000129", "category_aro_description": "Genes conferring resistance to beta-lactams."}}, "ARO_name": "Neisseria meningititis PBP2 conferring resistance to beta-lactam", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40660", "model_name": "Neisseria meningititis PBP2 conferring resistance to beta-lactam", "model_type_id": "40293"}, "2428": {"model_id": "2428", "ARO_accession": "3003961", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "farA is the membrane fusion protein that is part of the farAB efflux pump.", "model_sequences": {"sequence": {"3759": {"dna_sequence": {"fmax": "330767", "fmin": "329612", "accession": "NC_003112.2", "strand": "+", "sequence": "ATGGATACGCACACGGACGAAACAAAACTTCAAAACACGCAAGCCAAACGCAAACGCCGCCTGACGGCATTGACGCTGCTGTTCGCGCTTGCCGCCGCAGCCGCCGGGTCGGCGTTTTTTTTATGGTGGCAGCACGAAGAGGAAACGGAAGACGCTTATGTTGCCGGACGCGTGGTTCAGGTTACGCCGCAAAAGGGCGGTACGGTGCGGAAGGTTTTGCACGACGATACGGATGCCGTGAAAAAAGGCGACGTGCTGGCGGTATTGGACGACGATAATGATGTGCTGGCTTACGAGCGGGCAAAAAACGAGCTGGTTCAGGCGGTGCGGCAAAACCGCCGGCAAAATGCCGCCACTTCGCAGGCGGGGGCGCAGGTTGCCTTGCGCCGGGCGGATTTGGCACGCGCACAGGATGATTTGCGCCGCCGGTCTGCTTTGGCGGAATCGGGCGCGGTGTCCGCCGAAGAGCTGGCACACGCCCGTGCGGCAGTGTCTCAGGCGCAGGCGGCGGTCAAAGCGGCTTTGGCGGAAGAATCTTCGGCACGTGCGGCTTTGGGCGGTCAGGTTTCTTTGCGCGAACAGCCGGCGGTTCAGACGGCAATCGGCAGGTTGAAAGATGCGTGGTTGAACCTTCAGCGGACGCAAATCCGCGCGCCGGCGGACGGTCAGGTGGCGAAGCGTTCGGTGCAGGTCGGGCAGCAGGTGGCGGCAGGCGCGCCGCTGATGGCGGTGGTGCCGCTGTCGGATGTGTGGGTGGATGCTAATTTTAAAGAGACGCAGTTGCGGCATATGAAAATCGGACAGCCTGCCGAGCTGGTGTCCGATTTGTACGGCAAACAAATTGTTTATCGCGGCAGGGTGGCAGGTTTTTCGGCAGGTACGGGCAGCGCGTTTTCGCTGATTCCGGCGCAAAACGCAACGGGCAACTGGATTAAAGTGGTGCAGCGCGTCCCCGTCCGTATCGTGCTGAACCGCGAAGATGTGGACAGGCATCCGTTGCGTATCGGTTTGTCGATGACGGTTAAAGTGGATACTTCCGCCGCAGGCGCGCCTGTTTCAAAAACGCCGGGTGCGGCATTGCCGGAAATGGAAAGTACCGACTGGTCGGAAGTCGATCGGACGGTCGATGAAATCCTCGGGCAATCCGCGCCCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria meningitidis MC58", "NCBI_taxonomy_id": "122586", "NCBI_taxonomy_cvterm_id": "39597"}, "protein_sequence": {"GI": "NP_273367.1", "sequence": "MDTHTDETKLQNTQAKRKRRLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQVTPQKGGTVRKVLHDDTDAVKKGDVLAVLDDDNDVLAYERAKNELVQAVRQNRRQNAATSQAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHARAAVSQAQAAVKAALAEESSARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAPLMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSLIPAQNATGNWIKVVQRVPVRIVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAALPEMESTDWSEVDRTVDEILGQSAP"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}}, "ARO_name": "farA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40732", "model_name": "farA", "model_type_id": "40292"}, "2429": {"model_id": "2429", "ARO_accession": "3003962", "model_param": {"blastp_evalue": {"param_value": "1e-60", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "2000", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "farB is the cytoplasmic transporter protein that is part of the farAB efflux pump.", "model_sequences": {"sequence": {"3760": {"dna_sequence": {"fmax": "332317", "fmin": "330790", "accession": "NC_003112.2", "strand": "+", "sequence": "ATGGATTATCCACCGCTTAAGGGTGCGGCATTGGCGTGGGTTACGCTGTCTTTGGGGCTTGCCGTATTTATGGAAGTTTTAGATACGACTATCGCCAATGTCGCCGTTCCCGTCATCGCCGGCAACCTCGGTGCGGCAACCACTCAGGGGACGTGGGTCATCACTTCCTTTTCTGTGGCAAACGCCGTTTCCGTGCCGCTGACGGGCTTTTTGGCAAAACGCATCGGCGAGGTCAAATTGTTTACCGCCGCCGCTGTCGGTTTCGTCATCACATCGTGGCTGTGCGGTATTGCCCCCAACCTTCAGTCGCTGGTTGTTTTCCGCATCTTGCAGGGCTTTATCGCCGGGCCGCTGATTCCCTTGTCGCAAAGCCTGTTAATGGCATCCTATCCGCCCGCAAAACGGACGCTGGCACTGGCATTGTGGGCAATGACCGTCGTTGTCGCCCCTGTTCTCGGGCCGATACTCGGCGGCTGGATTTCCGGAAACTGGCATTGGGGTTGGATTTTCTTCATTAATATCCCTATCGGTATCATATCGGCATGGATTACATGGAAACATTTGAAATATCGGGAAACGGAAACCGTTAAAATGCCGACCGACTATGTCGGGCTTACATTGATGGTAGTCGGTATCGGCGCGTTACAGATGATGCTGGACAGGGGTAAGGAACTCGACTGGTTCGCCTCTGGAGAAATCATTACCTTGGGCGTAGTCGCACTGGTGTGCTTGTCGTATTTTATTGTTTGGGAATTGGGAGAAAAATATCCGATTGTCGATTTATCGCTGTTTAAAGATCGGAATTTTACCGTCGGCGTCATTGCCACGTCATTGGGTTTTATGGTGTATATGGGGACGCTGACCCTGCTGCCGTTAGTGTTGCAGACCAACCTGGGCTATACCTCCACGTGGGCAGGGCTTGCCGCCGCACCTGTCGGCATCCTGCCTGTTTTCCTGTCTCCGTTAATCGGCAGGTTCGGCAATAAAATCGATATGCGCCTGTTCGTAACTGCCAGCTTCCTGACCTTTGCCTTTACTTTCTATTGGCGTACGGATTTTTATGCCGATATGGATATTGGCAACGTCATCTGGCCGCAGTTTTGGCAGGGTGTCGGTGTCGCCATGTTTTTTCTGCCGCTGACCACCATCACACTGTCGCATATGAAGGGCGGGCAGATTGCCGCCGCAGGCAGCCTGTCGAATTTCTTGCGCGTGCTGATGGGCGGTGTCGGCGTATCCGTCGTCAGCACCCTGTGGGAACGGCGCGAAGCGTTGCACCACACACGCTTTGCCGAACACATCACGCCCTATTCCGCAACATTGCACGAAACGGCCGCTCATTTGTCCCAGCACGGCGTTTCCGACATTCAAACCCTAGGCATCATCAACAATACCATTACCCAGCAGGGTTTTATTATCGGCTCGAACGAAATCTTTATGGCGGGCAGCTTGTTATTCATTATCATGATACCCGTCATATGGCTGGCAAAACCGCCGTTCCACAACGGCGGCGGCGGTGGACATTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria meningitidis MC58", "NCBI_taxonomy_id": "122586", "NCBI_taxonomy_cvterm_id": "39597"}, "protein_sequence": {"GI": "NP_273368.1", "sequence": "MDYPPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFSVANAVSVPLTGFLAKRIGEVKLFTAAAVGFVITSWLCGIAPNLQSLVVFRILQGFIAGPLIPLSQSLLMASYPPAKRTLALALWAMTVVVAPVLGPILGGWISGNWHWGWIFFINIPIGIISAWITWKHLKYRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVVALVCLSYFIVWELGEKYPIVDLSLFKDRNFTVGVIATSLGFMVYMGTLTLLPLVLQTNLGYTSTWAGLAAAPVGILPVFLSPLIGRFGNKIDMRLFVTASFLTFAFTFYWRTDFYADMDIGNVIWPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLSNFLRVLMGGVGVSVVSTLWERREALHHTRFAEHITPYSATLHETAAHLSQHGVSDIQTLGIINNTITQQGFIIGSNEIFMAGSLLFIIMIPVIWLAKPPFHNGGGGGH"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}}, "ARO_name": "farB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40733", "model_name": "farB", "model_type_id": "40292"}, "2420": {"model_id": "2420", "ARO_accession": "3003946", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "DrrC is a part of the DrrABC efflux pump that provides self-resistance to the cell through excisional repair of DNA by daunorubicin\u2013 doxorubicin-induced formation of hydroxyl radicals.", "model_sequences": {"sequence": {"3751": {"dna_sequence": {"fmax": "3274902", "fmin": "3274071", "accession": "NC_000962.3", "strand": "+", "sequence": "ATGATCACGACGACAAGTCAGGAAATCGAGCTTGCACCCACACGTTTGCCAGGCTCGCAAAACGCTGCTCGGCTGTTCGTTGCGCAGACCCTTTTGCAGACCAACCGGTTGCTAACTCGATGGGCACGTGACTATATCACCGTTATCGGAGCGATCGTGTTACCGATTCTCTTCATGGTGGTGTTGAACATTGTGCTAGGTAACCTAGCTTATGTCGTAACCCACGACAGCGGGCTCTACAGCATTGTTCCGCTGATCGCACTCGGCGCCGCGATCACTGGGTCAACTTTTGTCGCGATCGACCTGATGCGCGAGCGCTCCTTCGGACTGCTTGCCCGACTGTGGGTGCTGCCCGTGCACCGAGCATCGGGCCTGATCTCTCGAATCCTGGCAAACGCGATTCGGACTCTGGTCACCACTTTAGTGATGCTAGGTACTGGGGTGGTATTGGGTTTCCGGTTTCGACAAGGCCTGATCCCGAGCCTCATGTGGATTAGTGTCCCGGTGATACTGGGCATCGCAATCGCGGCTATGGTCACTACCGTCGCGCTTTACACAGCACAAACCGTTGTTGTCGAAGGCGTTGAGCTGGTGCAAGCAATCGCGATCTTCTTCTCCACGGGTTTGGTGCCGCTCAACTCGTATCCAGGCTGGATTCAGCCGTTCGTCGCCCATCAGCCGGTGAGCTACGCCATCGCGGCGATGCGCGGTTTTGCAATGGGTGGTCCGGTCCTCTCTCCGATGATCGGGATGCTGGTGTGGACCGCGGGTATCTGCGTCGTATGCGCCGTACCCTTGGCCATTGGCTACCGACGGGCCAGCACGCATTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332", "NCBI_taxonomy_cvterm_id": "39507"}, "protein_sequence": {"GI": "NP_217454.1", "sequence": "MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTHDSGLYSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPFVAHQPVSYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "drrC", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40701", "model_name": "drrC", "model_type_id": "40292"}, "2421": {"model_id": "2421", "ARO_accession": "3003948", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "efrA is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer drug resistance.", "model_sequences": {"sequence": {"3752": {"dna_sequence": {"fmax": "1457", "fmin": "0", "accession": "HG970100.1", "strand": "+", "sequence": "AATATTTTGCTAGGGTACTTTGGTGCCAGAATTACAACAAACATTGTTCGTGATATTCGTGATGATTTATTTGAAAAGATTCAAACTTTCTCACACAGTGAATATGAAAGTATTGGGGTTTCTTCCTTAATTACGCGAACTACCAATGATGCATACCAAATTATGCTCTTCATGGGAAATATTTTACGTCTTGGCTTTATGACGCCAGTGATGTTTATTGCCAGTCTTTACATGGTGATGCGAACGAGTCCGTCGTTAGGAATGTACGTTTTAGGTGCCTTGCCTTTTCTGCTGCTAGCAGTTGTCGGAATTGCTCGTTTGTCAGAACCGTTATCTAAAAAGCAACAAAAGAACTTAGATGGAATCAATGGGATTTTAAGAGAAAATCTTTCTGGATTGCGGGTAATACGCGCATTTGTTAATGAAAAATTTGAAGAATCTCGTTTTAATAAAGTCAATGAAACTTACACTAAAAGTTCAAAAAGTCTGTTTCGTTTAATGGCAGCAGCCCAACCAGGGTTCTTTTTCTTATTTAATATTGTGATGGTCTTAATCATTTGGAGCGGGACTGTTCAAATCAGCCATGGGGATTTAGAAGTTGGGAATTTAATTGCTTTTATTGAATATATTTTTCATGCGCTGTTCTCGTTTATGTTATTTGCCAGTGTCTTAATGATGTATCCACGGGCTGCGGTTTCGGCTTCACGGATTCAAGAAGCCTTAGACATGGAACCAGCTATTCGTGAAGAAGAAGGCGTAACAGAAACAGCTACTAAAGGCTATCTAGAGTTTAAAAATGTAACCTTTGCCTATCCTGGACATGCGGAAAGCCCAGTTATTCGCAATGTAAGTTTTAAGGCGTCACCTGGTGAAACAGTGGCCTTTATTGGGAGCACAGGTAGTGGGAAATCAACATTAATTCAATTGATTCCACGGTTTTATGATGTATCAGAAGGTGAAATTTTAATCGATGGAGTGAACGTAAAAGAGTACAAACTTAGTGCATTACGCAATAAGATTGGCTATATTCCACAAAAAGCGTTACTTTTTACTGGTACAATTGCTGATAATCTTCGCTACGGTAAGGAAGATGCGACGTTAGAAGAAATGGAACGAGCAATTGACATTGCTCAAGCAACAGAATTTGTTTCACAAAAACCGCAAGGCTATGATGAACCTCTTTCAGAAGGTGGCACGAACTTTTCTGGTGGTCAAAAACAACGTTTAGCTATCGCACGGGCGATTATTCGCAATCCGGAAATTTATATATTTGATGATAGTTTTTCTGCGTTAGATTATCAAACAGATGCAAATTTACGAGCGCGTCTGAAAAAAGAAACAACAGAATCCACTGTTTTAATTGTGGCACAACGTGTTGGAACAATTATGCATGCGGACCGCATTGTTTGTTTTAAACGAAGGCGACGTGGTCGGAAATTTGGGCACCAACCATTTCA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"GI": "CDO61513.1", "sequence": "NILLGYFGARITTNIVRDIRDDLFEKIQTFSHSEYESIGVSSLITRTTNDAYQIMLFMGNILRLGFMTPVMFIASLYMVMRTSPSLGMYVLGALPFLLLAVVGIARLSEPLSKKQQKNLDGINGILRENLSGLRVIRAFVNEKFEESRFNKVNETYTKSSKSLFRLMAAAQPGFFFLFNIVMVLIIWSGTVQISHGDLEVGNLIAFIEYIFHALFSFMLFASVLMMYPRAAVSASRIQEALDMEPAIREEEGVTETATKGYLEFKNVTFAYPGHAESPVIRNVSFKASPGETVAFIGSTGSGKSTLIQLIPRFYDVSEGEILIDGVNVKEYKLSALRNKIGYIPQKALLFTGTIADNLRYGKEDATLEEMERAIDIAQATEFVSQKPQGYDEPLSEGGTNFSGGQKQRLAIARAIIRNPEIYIFDDSFSALDYQTDANLRARLKKETTESTVLIVAQRVGTIMHADRIVCFKRRRRGRKFGHQPF"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "efrA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40703", "model_name": "efrA", "model_type_id": "40292"}, "2422": {"model_id": "2422", "ARO_accession": "3003949", "model_param": {"blastp_evalue": {"param_value": "1e-140", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "efrB is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer multidrug resistance.", "model_sequences": {"sequence": {"3753": {"dna_sequence": {"fmax": "1086", "fmin": "0", "accession": "HG970103.1", "strand": "+", "sequence": "TTAGATACGTGTCGCATATTCAGGAGGAATGCTAAATCACCAGTAAATATTGCAAAGCATGCAAAATTCATTAGGAGACTTAAATGGTTATGTTCAGAAAATATGACTGGGTTCAGTGTCTTAAAACTATATGTTCGGAAAAAGAAACCCTTGAAAGGCTTTAAACAAGTCAATCATCGTTTTAAATGGTTTGGCTTCAAAGCATCCTTTATCTCAGGATTAATGTTGCCATTGGTTCAAATGACCGCTTATGGGACCTATATCGGGGTAGCTGTCCTTGGTAGTTACTATGTGGTTGCTGGTGTGATCGTAGTGGGGCAGTTACAAGCGTTTATTCAATATATTTGGCAAATTAGCCAACCAATGGGGAATATTACGCAGTTGTCTGCAGCTTTACAAAGCGCTTCAGCTTCGACCATGCGGATTTTTGAAATCCTAGATGAACCAGAAGAAGAACTTAACGAACAAGATGTTCCTTTGCCAGAACCTATTTTAGGCTCTGTTGAATTTGAAAATGTCAGCTTTAGTTATGACCCAGAAAAACCGTTAATTCGTAATTTGAACTTTAAAGTTGATGCGGGCCAAATGGTTGCGATTGTGGGACCAACTGGCGCTGGGAAAACAACCTTAATCAACTTACTGATGCGTTTTTATGATGTAACAGAAGGCGCCATTAAAATTGATGGTATTGACACAAAAAAAATGAACCGTAGTGATGTCCGATCTGTATTTGGAATGGTATTGCAAGATGCTTGGTTGTATAAAGGTACCATTGCAGATAACATTCGTTTTGGGAAGTTGGATGCCACGGATTATGAAGTTGTCGATGCAGCGAAAACGGCCAATGTGGATCACTTCATTCGGACAATGCCAGATGGGTATGAAATGGAAATCAATTCTGAGGGAGATAACGTTTCCCTTGGTCAAAAACAATTGTTGACCATTGCCCGAGCGGTAATTTCTGATCCGAAAATTTTGATTTTAGATGAGGCGACTAGTTCAGTCGATACACGCTTGGAAGCCTTAATTCAAAAAGCAATGGATCGTGTTATGGAAGGACGAACGAGTTTCGTTATTGCCCACCGT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"GI": "CDO61516.1", "sequence": "LDTCRIFRRNAKSPVNIAKHAKFIRRLKWLCSENMTGFSVLKLYVRKKKPLKGFKQVNHRFKWFGFKASFISGLMLPLVQMTAYGTYIGVAVLGSYYVVAGVIVVGQLQAFIQYIWQISQPMGNITQLSAALQSASASTMRIFEILDEPEEELNEQDVPLPEPILGSVEFENVSFSYDPEKPLIRNLNFKVDAGQMVAIVGPTGAGKTTLINLLMRFYDVTEGAIKIDGIDTKKMNRSDVRSVFGMVLQDAWLYKGTIADNIRFGKLDATDYEVVDAAKTANVDHFIRTMPDGYEMEINSEGDNVSLGQKQLLTIARAVISDPKILILDEATSSVDTRLEALIQKAMDRVMEGRTSFVIAHR"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "efrB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40704", "model_name": "efrB", "model_type_id": "40292"}, "2423": {"model_id": "2423", "ARO_accession": "3003950", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability.", "model_sequences": {"sequence": {"3754": {"dna_sequence": {"fmax": "968369", "fmin": "966620", "accession": "NC_000913.3", "strand": "+", "sequence": "ATGCATAACGACAAAGATCTCTCTACGTGGCAGACATTCCGCCGACTGTGGCCAACCATTGCGCCTTTCAAAGCGGGTCTGATCGTGGCGGGCGTAGCGTTAATCCTCAACGCAGCCAGCGATACCTTCATGTTATCGCTCCTTAAGCCACTTCTTGATGATGGCTTTGGTAAAACAGATCGCTCCGTGCTGGTGTGGATGCCGCTGGTGGTGATCGGGCTGATGATTTTACGTGGTATCACCAGCTATGTCTCCAGCTACTGTATCTCCTGGGTATCAGGAAAGGTGGTAATGACCATGCGTCGCCGCCTGTTTGGTCACATGATGGGAATGCCAGTTTCATTCTTTGACAAACAGTCAACGGGTACGCTGTTGTCACGTATTACCTACGATTCCGAACAGGTTGCTTCTTCTTCTTCCGGCGCACTGATTACTGTTGTGCGTGAAGGTGCGTCGATCATCGGCCTGTTCATCATGATGTTCTATTACAGTTGGCAACTGTCGATCATTTTGATTGTGCTGGCACCGATTGTTTCGATTGCGATTCGCGTTGTATCGAAGCGTTTTCGCAACATCAGTAAAAACATGCAGAACACCATGGGGCAGGTGACCACCAGCGCAGAACAAATGCTGAAGGGCCACAAAGAAGTATTGATTTTCGGTGGTCAGGAAGTGGAAACGAAACGCTTTGATAAAGTCAGCAACCGAATGCGTCTTCAGGGGATGAAAATGGTTTCAGCCTCTTCCATCTCTGATCCGATCATTCAGCTGATCGCCTCTTTGGCGCTGGCGTTTGTTCTGTATGCGGCGAGCTTCCCAAGTGTCATGGATAGCCTGACTGCCGGTACGATTACCGTTGTTTTCTCTTCAATGATTGCACTGATGCGTCCGCTGAAATCGCTGACCAACGTTAACGCCCAGTTCCAGCGCGGTATGGCGGCTTGTCAGACGCTGTTTACCATTCTGGACAGTGAGCAGGAGAAAGATGAAGGTAAGCGCGTGATCGAGCGTGCGACTGGCGACGTGGAATTCCGCAATGTCACCTTTACTTATCCGGGACGTGACGTACCTGCATTGCGTAACATCAACCTGAAAATTCCGGCAGGGAAGACGGTTGCTCTGGTTGGACGCTCTGGTTCGGGTAAATCAACCATCGCCAGCCTGATCACGCGTTTTTACGATATTGATGAAGGCGAAATCCTGATGGATGGTCACGATCTGCGCGAGTATACCCTGGCGTCGTTACGTAACCAGGTTGCTCTGGTGTCGCAGAATGTCCATCTGTTTAACGATACGGTTGCTAACAACATTGCTTACGCACGGACTGAACAGTACAGCCGTGAGCAAATTGAAGAAGCGGCGCGTATGGCCTACGCCATGGACTTCATCAATAAGATGGATAACGGTCTCGATACAGTGATTGGTGAAAACGGCGTGCTGCTCTCTGGCGGTCAGCGTCAGCGTATTGCTATCGCTCGAGCCTTGTTGCGTGATAGCCCGATTCTGATTCTGGACGAAGCTACCTCGGCTCTGGATACCGAATCCGAACGTGCGATTCAGGCGGCACTGGATGAGTTGCAGAAAAACCGTACCTCTCTGGTGATTGCCCACCGCTTGTCTACCATTGAAAAGGCAGACGAAATCGTGGTCGTCGAGGATGGTGTCATTGTGGAACGCGGTACGCATAACGATTTGCTTGAGCACCGCGGCGTTTACGCGCAACTTCACAAAATGCAGTTTGGCCAATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_415434.1", "sequence": "MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "msbA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40720", "model_name": "msbA", "model_type_id": "40292"}, "2424": {"model_id": "2424", "ARO_accession": "3003952", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules.  The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI.", "model_sequences": {"sequence": {"3770": {"dna_sequence": {"fmax": "1644", "fmin": "0", "accession": "NC_000913.3", "strand": "-", "sequence": "AGCTTTTCATTCTGACTGCAACGGGCAATATGTCTCTGTGTGGATTAAAAAAAGAGTGTCTGATAGCAGCTTCTGAACTGGTTACCTGCCGTGAGTAAATTAAAATTTTATTGACTTAGGTCACTAAATACTTTAACCAATATAGGCATAGCGCACAGACAGATAAAAATTACAGAGTACACAACATCCATGAAACGCATTAGCACCACCATTACCACCACCATCACCATTACCACAGGTAACGGTGCGGGCTGACGCGTACAGGAAACACAGAAAAAAGCCCGCACCTGACAGTGCGGGCTTTTTTTTTCGACCAAAGGTAACGAGGTAACAACCATGCGAGTGTTGAAGTTCGGCGGTACATCAGTGGCAAATGCAGAACGTTTTCTGCGTGTTGCCGATATTCTGGAAAGCAATGCCAGGCAGGGGCAGGTGGCCACCGTCCTCTCTGCCCCCGCCAAAATCACCAACCACCTGGTGGCGATGATTGAAAAAACCATTAGCGGCCAGGATGCTTTACCCAATATCAGCGATGCCGAACGTATTTTTGCCGAACTTTTGACGGGACTCGCCGCCGCCCAGCCGGGGTTCCCGCTGGCGCAATTGAAAACTTTCGTCGATCAGGAATTTGCCCAAATAAAACATGTCCTGCATGGCATTAGTTTGTTGGGGCAGTGCCCGGATAGCATCAACGCTGCGCTGATTTGCCGTGGCGAGAAAATGTCGATCGCCATTATGGCCGGCGTATTAGAAGCGCGCGGTCACAACGTTACTGTTATCGATCCGGTCGAAAAACTGCTGGCAGTGGGGCATTACCTCGAATCTACCGTCGATATTGCTGAGTCCACCCGCCGTATTGCGGCAAGCCGCATTCCGGCTGATCACATGGTGCTGATGGCAGGTTTCACCGCCGGTAATGAAAAAGGCGAACTGGTGGTGCTTGGACGCAACGGTTCCGACTACTCTGCTGCGGTGCTGGCTGCCTGTTTACGCGCCGATTGTTGCGAGATTTGGACGGACGTTGACGGGGTCTATACCTGCGACCCGCGTCAGGTGCCCGATGCGAGGTTGTTGAAGTCGATGTCCTACCAGGAAGCGATGGAGCTTTCCTACTTCGGCGCTAAAGTTCTTCACCCCCGCACCATTACCCCCATCGCCCAGTTCCAGATCCCTTGCCTGATTAAAAATACCGGAAATCCTCAAGCACCAGGTACGCTCATTGGTGCCAGCCGTGATGAAGACGAATTACCGGTCAAGGGCATTTCCAATCTGAATAACATGGCAATGTTCAGCGTTTCTGGTCCGGGGATGAAAGGGATGGTCGGCATGGCGGCGCGCGTCTTTGCAGCGATGTCACGCGCCCGTATTTCCGTGGTGCTGATTACGCAATCATCTTCCGAATACAGCATCAGTTTCTGCGTTCCACAAAGCGACTGTGTGCGAGCTGAACGGGCAATGCAGGAAGAGTTCTACCTGGAACTGAAAGAAGGCTTACTGGAGCCGCTGGCAGTGACGGAACGGCTGGCCATTATCTCGGTGGTAGGTGATGGTATGCGCACCTTGCGTGGGATCTCGGCGAAATTCTTTGCCGCACTGGCCCGCGCCAATATCAACATTGTCGCCATTGCTCAGGGATCTTCTGAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_416715.1", "sequence": "MELLVLVWRQYRWPFISVMALSLASAALGIGLIAFINQRLIETADTSLLVLPEFLGLLLLLMAVTLGSQLALTTLGHHFVYRLRSEFIKRILDTHVERIEQLGSASLLAGLTSDVRNITIAFVRLPELVQGIILTIGSAAYLWMLSGKMLLVTAIWMAITIWGGFVLVARVYKHMATLRETEDKLYTDFQTVLEGRKELTLNRERAEYVFNNLYIPDAQEYRHHIIRADTFHLSAVNWSNIMMLGAIGLVFWMANSLGWADTNVAATYSLTLLFLRTPLLSAVGALPTLLTAQVAFNKLNKFALAPFKAEFPRPQAFPNWQTLELRNVTFAYQDNAFSVGPINLTIKRGELLFLIGGNGSGKSTLAMLLTGLYQPQSGEILLDGKPVSGEQPEDYRKLFSAVFTDVWLFDQLLGPEGKPANPQLVEKWLAQLKMAHKLELSNGRIVNLKLSKGQKKRVALLLALAEERDIILLDEWAADQDPHFRREFYQVLLPLMQEMGKTIFAISHDDHYFIHADRLLEMRNGQLSELTGEERDAASRDAVARTA"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "YojI", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40722", "model_name": "YojI", "model_type_id": "40292"}, "2425": {"model_id": "2425", "ARO_accession": "3003953", "model_param": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "hmrM is a multidrug efflux pump belonging to the MATE family and functions as a  Na+/drug antiporter.", "model_sequences": {"sequence": {"3756": {"dna_sequence": {"fmax": "1146068", "fmin": "1144673", "accession": "NC_017452.1", "strand": "-", "sequence": "TTATTTAAGTTTTTCTAAACGTTGTAAAATAGCGTTGTCGTTCATAGCTTGCATTTTTTTCATTCTCAAAGAAAGTAAGAATGCCGCAAAAGTGAGCGAGACCACAAAGGCAATCCAGAAACCTTTCGCATCAATGTGTGGCACAAGCCAATCTGTACGACCTAGCGTATAACCAAGTGGCACACCAATTACCCAATAAGAGAAAAGGGTAATGTATAAAATGACTTTAGTATCTTTATAACCACGTAAAATACCACCAACCACCATTTGAATGGTATCTGAAAATTGATAAAGTGCGGCAAATAATAATAGATTTGCTGCCATGGCGATGACAATTTCATCTGTCACGAAGATCGATGCAATTTCATAACGGAAAAAAATCGTAATTAATGCAGTAACAATTGTCACAGTTAGCCCTAATAATAATGCGGCATAGCCAATTTTCTTCGCATTTTGTGGAGAACCTGCACCCAATGCTTGTCCAACTAAAATCGTCGTTGCCATACCAATCGACATAGGGAACATAAAAATAAAAGAACTAGTATTCAGCGTAATTTGATGGCTTGCCACAATAGTTGCACCCAGCGGAGAAAGCATTAAGGACGTAAGTGCATATAACGCCACTTCGCAACAAATTGCAATGGCAATGGGTAATCCTAAACGCAGTAATTTTTTAAGTGTTTTCGGATTTGGCATTTCAATTAATTGACTAAATACTTTTAGTGAACGTTCTTGAGTATTCGTGTAGGAATAGAAAATCATCATTAAGCACATTGCCCAGTTCACAATAGCTGTCGCAATACCACAGCCCACCGCACCAAAAGCAGGCATACCAAATTTTCCATAAATAAAAATGTAATTAAGCGGAATATTAATCAATAAACCTAAAAAGGTAATGACCATCGCAGGCTTGGTTTTCTCAATCCCATCATTTAAACAACGAAAATTAATCAGCATCAAATAAGCTGGCAATCCCCACAACATCGCGTGTAAATAATTGCGTGCTAAATCTGACATTTTGCTTTCCATTTGCATATATTGCAGCGGAATTTCACAGAAATAAATCAGTAAACCTAAAGGAATACTCACGCCTAACACAAGCCAAATGCCTTGGCGAACTTGATGTGCAATGCGATGGTGTTGGCCTGAACCATTCAAATAAGAAATTGTAGGCGGCAATGCCAACAATAAACCTTGCCCAAAAAACATCAATGGCATCCAAATTGAAGCACCAATAGAAATGGCTGCCATATCAGTGGAACTCACTCGCCCCGCCATAATGGTATCCGCTAATCCCATTGAGTTTTGTGCAATTTGCGCTAATAAAATAGGCAAGGAAATTTTAATCAACTTTTTAATATCAGTGTGGTATTGAGATAAAAGACGAAAATTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Haemophilus influenzae", "NCBI_taxonomy_id": "727", "NCBI_taxonomy_cvterm_id": "36768"}, "protein_sequence": {"GI": "WP_014550864.1", "sequence": "MNFRLLSQYHTDIKKLIKISLPILLAQIAQNSMGLADTIMAGRVSSTDMAAISIGASIWMPLMFFGQGLLLALPPTISYLNGSGQHHRIAHQVRQGIWLVLGVSIPLGLLIYFCEIPLQYMQMESKMSDLARNYLHAMLWGLPAYLMLINFRCLNDGIEKTKPAMVITFLGLLINIPLNYIFIYGKFGMPAFGAVGCGIATAIVNWAMCLMMIFYSYTNTQERSLKVFSQLIEMPNPKTLKKLLRLGLPIAIAICCEVALYALTSLMLSPLGATIVASHQITLNTSSFIFMFPMSIGMATTILVGQALGAGSPQNAKKIGYAALLLGLTVTIVTALITIFFRYEIASIFVTDEIVIAMAANLLLFAALYQFSDTIQMVVGGILRGYKDTKVILYITLFSYWVIGVPLGYTLGRTDWLVPHIDAKGFWIAFVVSLTFAAFLLSLRMKKMQAMNDNAILQRLEKLK"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "hmrM", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40723", "model_name": "hmrM", "model_type_id": "40292"}, "2426": {"model_id": "2426", "ARO_accession": "3003954", "model_param": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "efmA is an MFS transporter permease in  E. faecium.", "model_sequences": {"sequence": {"3757": {"dna_sequence": {"fmax": "1571", "fmin": "284", "accession": "AB467372.1", "strand": "+", "sequence": "ATGGAAAATGAACAGTCGGTCGTTTTAACGAATTGGAAGAGAAATTATTTGTTCTTTTTATCGGGACAGTTTTTGTCAGGAATCACTAGTATGGTCGTCCAATATGCGATCATCTGGTATTTGACAAGAGAAACCGGTTCGGCGACAATTTTGAGTTTTGCTACTTTACTAGGAATGATTCCCATGGTTTTACTAAGCCCATTTGTAGGACCGCTAGTGGATCGCTGGGATAAAAAAGCTCTTTTGATTGTCACGGATATTATTGTAGCGATTTTCGCGCTTATTTTAGCAGTAGTCGGAACGATTTCAGAATCCTTCCCGATTTGGCTAGTTTTTGTGTCTTTGTTTATGCGTTCGGTCGCACAAACATTCCAAATGCCAACGATCCAGTCGATTATGCCGACAATCGTTCCATCTTCTCACATAACAAGGACGAATGGACAGTTAGGAATGGTCCAATCAGCGAATTTCATCATTGCGCCAGCTCTAGGTGCGGCTTTGTTTTCAGTCGTTCCTGTCAATTACCTTATTTTATTAGATGTATTGGGGGCAGTTTTTGGTGTCGGCTTATTGATTTTTGTGAAGATCCCAAAAGTTTCTCCTGAAATATTGGAAGTTCCGCTTACTATTTTTAAAGATGCAAAATTTGGGCTGCAGCAATTGATGGATAATAAAGGGTTATGGTACATAACGATCAATGGTGCATTTGTGATGCTGTTGTTCATGCCAGCAATCAGTCTGTATCCATTGATGACGCTAGATTACTTTGGTGGTTCCGTTGGACAGGCGGGAGCAGTGGAAGTAGTCTACGCAGTCGGAATGCTCTTAGGCGGTGCACTGATCAGTTTTATAGGAACATGGAAAGACCGAATGAAACCTATTATTATAGCCTACATCATTATGGGCCTGACGATCGGTGCAAGCGGATTGGTTCCAAACGATAGTCAAGGGTTCTTGTACTTTCTTATCTTGAATGCAGGAGCAGGTTGTGCAACGCCATATTTCAATACACTGCTGATGGCAATGATCCAGCAGAGTTATGAATCGAATGTTTTAGGTCGTGTCTTAGGGAACTTCAACTCTTTGATGAACCTGGCAGGTCCAATTGGATTATTATTTGCAGGACCATTAGCTGATCGTTTAGGGGTAGAAAAAATGTTCTTGTTTTCCGGAATCGGGATTTTATTATGCGGAATCGTTTTATTTTTAACGTCAGCTGCCCGAAATTATGATAAAGAATTACAGAAAAAACTGGTAAAAGAACACCATGAGCAAAAAGACGAATAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"GI": "BAG75524.1", "sequence": "MENEQSVVLTNWKRNYLFFLSGQFLSGITSMVVQYAIIWYLTRETGSATILSFATLLGMIPMVLLSPFVGPLVDRWDKKALLIVTDIIVAIFALILAVVGTISESFPIWLVFVSLFMRSVAQTFQMPTIQSIMPTIVPSSHITRTNGQLGMVQSANFIIAPALGAALFSVVPVNYLILLDVLGAVFGVGLLIFVKIPKVSPEILEVPLTIFKDAKFGLQQLMDNKGLWYITINGAFVMLLFMPAISLYPLMTLDYFGGSVGQAGAVEVVYAVGMLLGGALISFIGTWKDRMKPIIIAYIIMGLTIGASGLVPNDSQGFLYFLILNAGAGCATPYFNTLLMAMIQQSYESNVLGRVLGNFNSLMNLAGPIGLLFAGPLADRLGVEKMFLFSGIGILLCGIVLFLTSAARNYDKELQKKLVKEHHEQKDE"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "efmA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40724", "model_name": "efmA", "model_type_id": "40292"}, "2427": {"model_id": "2427", "ARO_accession": "3003955", "model_param": {"blastp_evalue": {"param_value": "1e-80", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "efpA is an MFS transporter found in Mycobacterium tuberculosis.", "model_sequences": {"sequence": {"3758": {"dna_sequence": {"fmax": "3154631", "fmin": "3153038", "accession": "NC_000962.3", "strand": "-", "sequence": "TTACAGCTCGCCGGCGTCGATCGCTTCCTTGACCTCCTGCGCATGGGCAACCTGCTGCGGCGTATACCCGATAAACAGCGCCATACCGCCGACGATGATGGCCGCTCCGGCCACCCACAGCAGGCCGTAGGTGTAGGCGTGGTCAAGCGCGGCCAACTGCACGTCGTTCATGAACTTCACCGGACCGGTGGTACCGCCCAGGTACAGCGTGCGCGACGTGATCACAGCCTGGATGACGGCGAGCACCAGCGGACCGCCCAGGCTCTGCAGCATCAGCGCAATTGCCGATACCGGACCGATCTGGTCGAAGCCGACGCCAGCGATCGCCGACAGAGTCAGCGGGACGACGGCCATGCCGATGCCAATCCCGCCGACGACGATCGGCATGACCAGGTTGGGGAAGTAGGGCACACCACGGTGCATGAAAAATGAGCCGTACAGCATGGCGCCGAATAGCAGATATCCGCCGCCGATGGTCAACACCCGTGGCGAAAACCGGGACACCAGCTGCGAGGACACACCTAGGCCGATTCCCATCGCGATGACGAACGGGATGAAACCTACGCCCGCGCGTAGCGCGCTGTAGCCCAAGATGTCCTGCACGTACAGGCCGATGCAGACGGTCAGGCTGAACATGACGCCGCCGGCCAACAGGATCGCGCTGAACGTGACCAACCGGTTGCGGTCGCGGAACAAGTGGAACGGCACGACGGGGTTCTCGGCAGTGCGCTCCACGATGACAAACGCGACAGCGGCCGCCAAGGCCACCAGGCCCGAACCGATGGTAATGCCTGACATCCAGCCCTTTTCAGGACCGATCGAGAAGGCGAAAACCGCCGCGGTGCATGCCAGCGTGGCCAGTATGGCCCCGGTGGCGTCGAGCTTCATCCGTTCTTTGTTGGTTTCCCGTAGGGCGGTGCGGGCCAGGTAGATCATCACCAGCCCGATCGGCACGTTCACCAGGAACGCCCACCGCCATGACACCTCGGTCAGTGCTCCGCCGACCACCAGCCCCATCACCGACCCGATCGCGGTCATCGCGGCGAACACCGCCGTCGCGGCGTTGCGGGCAGGTCCCTTGGGGAACGTGGTCGCCACCAGCGCCAGACCGGTCGGAGATGCGATGGCCGACCCCACACCCTGGGACAACCGGGCGATCACCAACGTCGCCTCGTCCCAGGCGACCGCGCACAGCACCGACGAGATGGTGAATAGCGCAACGCCAACAATGAAGGTGCGTTTGCGCCCGATGGTGTCGCCAAGCCGGCCGCCGAGCAGCATCAGCCCGCCGAAGGTCAGCACGTAGGCGGTGATCACCCAGCTGCGGCCGGCATCAGACAAGCTCAGCTCGTTTTGAATCTTAGGTAGCGCGACGATGGCGACGGTGCTGTCCATGGTCGCCAGCAGCTGCATCCCGCCGATAGCAATAACCGCAGCGATAAAGCTGCGCGAGGGCAGCCAAGTCGGGTAGTACCTGCTGGGGCGCTCTGAAGCGGTCTCCTCCGAGCGCGGCGGGCGCATCGGGGCCGGACGGTGTGGGCGTCCGGCTGTCCAGTTACGGACCGCCCGCTCTGTGTCGTTGAGAGCCGTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332", "NCBI_taxonomy_cvterm_id": "39507"}, "protein_sequence": {"GI": "NP_217362.1", "sequence": "MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQLAALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "efpA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40726", "model_name": "efpA", "model_type_id": "40292"}, "2411": {"model_id": "2411", "ARO_accession": "3003940", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4489": "N57K", "4490": "H80P"}, "clinical": {"4489": "N57K", "4490": "H80P"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutations in Shigella flexneri gyrA observed to confer resistance to fluoroquinolone antibiotics.", "model_sequences": {"sequence": {"3741": {"dna_sequence": {"fmax": "2354859", "fmin": "2352231", "accession": "NC_004337.2", "strand": "-", "sequence": "TTATTCTTCTTCTGGCTCGTCGTCAACGTCCACTTCCGGAGCAATTTCATCATCCCCTTCCGCGGCACTGCCGTCGATGGTATCCAGATCTTCCTCGTCAACCGGTTCAGCAACACGCTGCAGACCCACTACGTTTTCATCTTCCGCAGTACGGATGAGGATCACGCCCTGGGTGTTACGGCCCACGATGCTGATTTCTGAAACGCGAGTACGTACCAGCGTACCGGCATCGGTGATCATCATGATCTGGTCGCAGTCATCTACCTGCACCGCGCCAACCACTAAACCGTTACGTTCGGTAACCTTGATGGAGATAACCCCTTTCGTCGCACGCGACTTGGTTGGGTATTCCGCCACTGCAGTACGTTTACCGTAACCGTTTTGCGTTGCGGTGAGGATTGCGCCATCGCCACGAGGCACGATCAGAGAGACGACTTTATCGCCTTCACCTAAGCGAATACCGCGCACACCAGTGGTATTGCAGCCCATCGCACGGACAGAAGACTCTTTAAAGCGCACCACTTTACCTTCGGCGGAGAACAGCATTACTTCATCTTCGCCACTGGTCAGATCAACGCCGATCAGCTCATCGCCGTCAACCAGTTTGATCGCCACTTTACCGGCGGTACGCAGACGGTTGAATTCGGTGAGGACGGTTTTCTTCACAGTACCGTTAGCGGTCGCCATGAAGACTTTCACGCCTTCTTCAAACTCGGTCACCGGCAGGATCGCGGTGATACGTTCGTCCTGTTCCAGCGGTAGCAGGTTGACGATCGGACGACCGCGCGCGCCACGAGTGGCTTCCGGCAACTGGTAAACTTTCATCGAATAGACGCGACCACGGCTGGAGAAGCACAGAATATGGTCGTGCGTGTTCGCCACCAGCAGTCGGTCGATAAAGTCTTCTTCTTTAATACGTGCGGCAGATTTACCTTTCCCGCCACGACGCTGCGCTTCGTATTCAGAAAGCGGCTGATATTTAACGTAGCCCTGGTGAGAGAGCGTCACGACCACATCTTCCTGGGTGATCAGATCTTCCAGGTTGATGTCTGCGCTGTTGGCGGTGATTTCAGTACGACGTTTGTCACCGAACTGTTCACGAACCAGCTCCAGCTCTTCGCGGATCACTTCCATCAGACGATCGGCGCTACCAAGAATACGCAACAGTTCCGCGATCTGATCCAGCAGCTCTTTGTATTCGTCGAGCAGTTTTTCGTGCTCAAGGCCGGTCAGTTTCTGCAAACGCAGATCCAGAATCGCCTGAGCTTGCTGTTCGGTCAGGTAGTACAGACCATCACGCACGCCGAACTCTGGCTCCAGCCATTCCGGACGCGCAGCATCGTCGCCAGCACGTTCCAACATGGCGGCAACGTTGCCCAGCTGCCACGGATTAGCAACCAGCGCAGTTTTCGCTTCTGCAGGCGTCGGCGCATGACGGATCAGTTCGATGATCGGGTCAATGTTCGCCAGCGCCACGGCTAATGCTTCAAGGATATGAGCACGATCGCGAGCTTTACGCAGTTCGAAAATAGTACGACGGGTCACCACTTCACGGCGGTGACGAACAAACGCCGCGATGATGTCTTTCAGGTTCATGATCTTCGGCTGACCATGGTGCAATGCCACCATGTTGATACCGAAAGAAACCTGCAACTGGGTCTGGGAGTAGAGGTTGTTGAGCACAACTTCACCGACCGCATCGCGTTTCACTTCAATCACGATGCGCATACCGTCTTTGTCAGACTCGTCACGCAGCGCGCTGATGCCTTCCACGCGTTTTTCTTTTACCAGTTCCGCAATCTTCTCGATCAGGCGCGCTTTGTTTACCTGATACGGAATTTCGTGGACGATAATGGTTTCACGTCCGGTTTTGGCGTCAACTTCCACTTCAGCACGGGCGCGGATATATACCTTGCCGCGACCGGTACGGTAAGCTTCTTCAATACCGCGACGACCGTTAATGATTGCCGCCGTCGGGAAGTCCGGCCCCGGGATGTGTTCCATCAGCCCTTCAATGCTGATGTCTTCATCATCGATATACGCCAGACAACCGTTGATGACTTCCGTCAGGTTGTGCGGCGGGATGTTGGTTGCCATACCTACGGCGATACCGGAAGAACCGTTCACCAGCAGGTTAGGAATTTTGGTTGGCATGACGTCGGGAATTTTTTCCGTGCCGTCATAGTTATCAACGAAATCGACCGTCTCTTTTTCGAGATCGGCCATCAGTTCATGGGCAATTTTCGCCAGACGGATTTCCGTATAACGCATTGCCGCCGCAGAGTCGCCGTCGATGGAACCGAAGTTACCCTGACCGTCTACCAGCATGTAACGCAGCGAGAATGGCTGCGCCATACGGACGATCGTGTCATAAACCGCCGAGTCACCATGGGGATGGTATTTACCGATTACGTCACCAACGACACGGGCAGATTTTTTATAGGCTTTGTTCCAGTCATTGCCTAGTACGTTCATGGCGTAAAGTACGCGACGGTGTACCGGCTTCAGGCCATCTCGGACATCTGGCAGCGCACGGCCAACAATGACCGACATCGCATAATCCAGATAGGAGCTCTTTAGCTCTTCCTCAATGTTGACCGGTGTAATTTCTCTCGCAAGGTCGCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella flexneri 2a str. 301", "NCBI_taxonomy_id": "198214", "NCBI_taxonomy_cvterm_id": "40665"}, "protein_sequence": {"GI": "NP_708120.1", "sequence": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAEPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Shigella flexneri gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40664", "model_name": "Shigella flexneri gyrA conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2410": {"model_id": "2410", "ARO_accession": "3003939", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4487": "W106G"}, "clinical": {"4487": "W106G"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutations in Salmonella parC gene implicated in decreased susceptibility to fluoroquinolone antibiotics, primarily ciprofloxacin and nalidixic acid.", "model_sequences": {"sequence": {"3739": {"dna_sequence": {"fmax": "3339205", "fmin": "3336946", "accession": "NC_003197.1", "strand": "-", "sequence": "TTACTCTTCGCTGTCGCCATGACTTACGCGATGCGGCGAATCAATCTCAATGCGATCGATACGCTGCAGGCCGCGCATTAATGTGCCACGGCGTCCGCGTTCACCGACCACCTTTTGTAACTCTTCAGGGCGCAGTTTGATTTTGCGCTTCCCGACATGGATAGTCAGAGTGCTTTGTGGCGGCAGCACGTACAGGTGCGCCAGTCCATCATCGCCTTTCGCCGCTTCTGCAGAGGGGATATTAATGATCTTATTCCCTTTGCCTTTCGACAGCTGCGGCAGAGAGTCTACCGGGAACATCAACATCCGTCCGGCCTGGGTAATCGCCAGCAGCATATCGTGCTCGTCTTCAATCACCAGCGGCGGCATGACGTGCGCATTTTCCGGCAGTGTAATCAATGTCTTACCGGCACGGTTACGGGCAACCAGATCGTTAAACGTACAAACGAAGCCGTAGCCCGCATCCGACGCCATCAGCAGTTTCTGGTCATCGCCTTCCATCAGCATATGCTCTACGGTCGCCCCCGGCGGCAGCGTGAGTTTGCCGGTCAGCGGCTCGCCCTGCCCACGCGCCGACGGAAGCGTAATGGGATCAATAGCATAGCTGCGCCCGGTGGTATCAATAAACACCACCGGTTGATTGCTCTTACCTTTCACCGCGGCTTTAAAGCTGTCGCCCGCTTTATAGTTAAGCCCCGGCGCATCAATATCATGACCTTTGGCGCTGCGCACCCAGCCCATCTGCGACAGCACGATAGTCACCGGTTCGGACGGCAGCATATCGTGTTCGCTCATCGCTTTAGCTTCTTCGCGCTCACGCAGCGGAGAACGGCGATCGTCGCCATAGGCATCGGCGTCCGCCTGTAGTTCTTTTTTCAGCAAGGTATTCATTTTGCGTTCGGACGCGAGAATGCCCTGCAACTGGTCCCTCTCTTTTTCCAGCTCGTCCTGCTCGCCGCGAATTTTCATCTCTTCCAGTTTGGCGAGATGGCGCAGTTTCAGTTCGAGAATCGCTTCCGCCTGGGTTTCGCTGATGCCGAAACGCGACATCAGCGCGGGTTTTGGCTCGTCTTCGCTACGGATAATCTCAATCACTTCGTCGATGTTGAGAAACGCCACCAGCAAACCTTCGAGGATATGCAGGCGCTTAAGCACTTTCTCCAGACGATAGTTCAGACGACGGCGCACCGTGTCGCGGCGGAACGCCAGCCACTCGGTGAGGATCTCCAGCAGGTTTTTCACCGCCGGACGACCATCCAGACCGATCATGTTCAGGTTAATACGGTAGCTTTTTTCCAGATCGGTGGTGGCGAACAGATGGTTCATCACCTGTTCCATATCCACACGGTTGGAGCGTGGCACAATCACTAAACGCGTCGGGTTTTCGTGATCCGATTCATCGCGCAGATCGTCCACCATCGGCAGTTTTTTATTACGCATCTGCGCAGCAATCTGCTCCAGCACTTTCGCGCCAGAGACCTGATGCGGCAGCGCGGAAATTACCACAGCGCCGTCTTCTTTGGTCCATACCGCGCGCATACGCACGGAGCCCCGCCCGTTTTCGTAAATTTTACGAATTTCCGCACGTGGGGTAATGATCTCCGCTTCGGTCGGGTAATCCGGCCCCTGAACGATATCCAGCAACTGATCCAGCGTCGTTTTCGGCTGCTCAATCAGCGTAATCGCCGCTTTCGCCACTTCGCGCAGGTTGTGCGGCGGGATATCTGTTGCCATGCCCACCGCAATACCGGTGGTGCCGTTCAGCAGGATGTTCGGCAGACGCGCCGGTAACATTTTCGGTTCCTGCATGGTGCCGTCGAAGTTTGGCACCCAGTCCGCCGTCCCCTGACCGAGTTCGCTTAACAGCAGCTCGGCGTATTTGGACAGGCGGGATTCGGTATAACGCATCGCCGCGAATGACTTCGGATCATCCGGCGCGCCCCAGTTCCCCTGGCCATCGACCAGCGGGTAACGGTAAGAGAACGGCTGCGCCATCAGCACCATGGCTTCATAGCAGGCGCTGTCGCCATGCGGGTGATACTTACCCAGTACGTCACCAACGGTACGGGCGGATTTTTTAAATTTAGCGGTGGCGTTCAGCCCCAGCTCTGACATCGCATAGACGATGCGGCGCTGTACCGGCTTCAGGCCGTCGCCAATAAACGGCAACGCACGATCCATGATCACGTACATGGAGTAGTTTAAGTAGGCGTTTTCCGTAAATTCATGTAGCGCAAGGCGCTCTGCCATATCGCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Typhimurium str. LT2", "NCBI_taxonomy_id": "99287", "NCBI_taxonomy_cvterm_id": "35734"}, "protein_sequence": {"GI": "NP_462089.1", "sequence": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTADWVPNFDGTMQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDQLLDIVQGPDYPTEAEIITPRAEIRKIYENGRGSVRMRAVWTKEDGAVVISALPHQVSGAKVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILTEWLAFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRSEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQDELEKERDQLQGILASERKMNTLLKKELQADADAYGDDRRSPLREREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSNQPVVFIDTTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVEHMLMEGDDQKLLMASDAGYGFVCTFNDLVARNRAGKTLITLPENAHVMPPLVIEDEHDMLLAITQAGRMLMFPVDSLPQLSKGKGNKIINIPSAEAAKGDDGLAHLYVLPPQSTLTIHVGKRKIKLRPEELQKVVGERGRRGTLMRGLQRIDRIEIDSPHRVSHGDSEE"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Salmonella enterica parC conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40662", "model_name": "Salmonella enterica parC conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2412": {"model_id": "2412", "ARO_accession": "3003941", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4494": "S129P", "4493": "D111H", "4492": "A85T"}, "clinical": {"4494": "S129P", "4493": "D111H", "4492": "A85T"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutation in parC conferring resistance to fluoroquinolone antibiotics in Shigella flexneri,", "model_sequences": {"sequence": {"3742": {"dna_sequence": {"fmax": "3161413", "fmin": "3159154", "accession": "NC_004337.2", "strand": "-", "sequence": "TTACTCTTCGCTATCACCGCTGCTGGCACGGCGAGGAGAGTCGATCTCAACACGATCGATACGCTGCAAACCGCGCATCAACGTACCGCGGCGTCCACGTTCGCCAGTGACTTTCTGTAGCTCTTCCGGACGCAGTTTAATTTTGCGTTTCCCAACATGAATGGTCAGCGTGCTTTGCGGCGGCAGAACGTACAGTTGCGCCAGACCATCCTCGCCACGCGCGGCTTCTGCCGATGGAATGTTGATAATCTTGTTGCCTTTGCCCTTCGACAGCTGCGGCAGATCGCTTACCGGGAACATCAACATACGGCCTGCCTGAGTGATTGCCAGCAGCATATCGGAAGCATCTTCAATCACCACCGGCGGCATAACATGGGCATTTTCCGGTAAGGTGATCAAAGCCTTACCCGCACGGTTACGCGCTACCAGATCGTTAAAGGTGCAGACGAAACCGTAACCCGCATCGGAAGCCATCAGCAGTTTCTGATCGTCGCTTTCCATCAGCATATGGTCAACGGTCGCCCCAGGCGGCAACGTTAATTTGCCGGTGAGTGGTTCGCCCTGACCACGCGCCGACGGCAGCGTAATCGGGTCGATGGCATAGCTACGACCGGTGGAATCAACAAACACTACCGGTTGGTTACTCTTACCTTTCACCGCCGCTTTGAAGCTATCACCCGCTTTATAATTCAGGCCCGGCGCGTCGATATCATGGCCTTTAGCGCTGCGTACCCAGCCCATCTGCGACAGCACAATGGTGACAGGTTCAGACGGCAGCATGTCGTGCTCGCTCATCGCTTTCGCTTCTTCGCGTTCCTGCAACGGCGAACGACGATCGTCACCGTAGGCTTGCGCGTCTGCCTGCAGTTCTTTCTTCAGCAGGTTATTCATTTTACGCTCGGAAGCCAAAATGCCCTGCAACTGGTCGCGCTCTTTTTCCAGCTCACTCTGCTCACCGCGAATCTTCATCTCTTCCAGTTTGGCAAGATGACGCAGTTTCAGTTCGAGGATCGCTTCCGCCTGGGTTTCCGTAAGGCCAAACCGCGACATCAGCGCCGGTTTCGGTTCATCTTCGTTACGAATGATCTCAATCACTTCGTCGATGTTGAGAAACGCCACCAGCAAACCTTCCAGGATATGCAGGCGCTTGAGGACTTTCTCCAGACGATAGTTCAGTCGGCGGCGCACGGTATCGCGACGGAACACCAGCCATTCGGAGAGGATTTCCAGCAGGTTTTTCACCGCCGGACGACCATCCAGACCGATCATATTGAGGTTAATGCGATAGCTCTTTTCCAGATCGGTGGTAGCGAAGAGGTGGTTCATCACCTGATCCATATCCACGCGGTTGGAACGCGGCACAATCACCAGACGGGTCGGGTTCTCGTGGTCAGATTCATCGCGCAGATCGTCAACCATCGGCAGCTTTTTGTTGCGCATTTGCGCAGCAATTTGCTCCAGTACGCGCGCACCTGAAACCTGATGCGGTAATGCGCTGATAACCACCGCGCCATCTTCTTTCTTCCACACCGCGCGCATACGCACTGAACCACGTCCGTTCTCGTAGATTTTACGAATCTCGGCGCGCGAAGTGATAATTTCCGCTTCAGTCGGATAATCCGGCCCCTGCACGATATCCAGCAGCTGATCGAGCGTAGTTTTCGGCTGGTCGATTAATGCGATTGCCGCCTGAGCTACTTCACGCAGGTTATGCGGTGGAATATCGGTCGCCATGCCGACGGCAATACCGGTGGTGCCGTTAAGCAAAATGTTTGGCAGACGGGCAGGTAGCATTTTCGGCTCCTGCAAAGTGCCGTCGAAGTTTGGCACCCAGTCAGCCGTCCCCTGCCCCAGCTCGCTCAATAGCAGCTCGGAATATTTCGACAACCGGGATTCGGTGTAACGCATTGCCGCGAACGATTTCGGATCGTCCGGCGCGCCCCAGTTCCCCTGACCATCAACCAGCGGATAACGGTAAGAGAACGGCTGCGCCATCAGGACCATCGCTTCATAACAGGCGCTATCGCCGTGCGGATGGTATTTACCCAGTACGTCACCGACGGTACGGGCCGATTTTTTAAATTTGGCGCTGGCATTCAGGCCCAGTTCAGACATCGCATACACAATGCGGCGCTGAACAGGTTTCAGACCATCACCAATAAACGGCAACGCACGGTCCATGATCACGTACATGGAGTAGTTTAAGTAGGCGTTTTCCGTAAATTCATGTAGCGCAAGGCGCTCTGCCATATCGCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella flexneri 2a str. 301", "NCBI_taxonomy_id": "198214", "NCBI_taxonomy_cvterm_id": "40665"}, "protein_sequence": {"GI": "NP_708834.1", "sequence": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVRMRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPLQEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSNQPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDLPQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "Shigella flexneri parC conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40666", "model_name": "Shigella flexneri parC conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2416": {"model_id": "2416", "ARO_accession": "3003942", "model_param": {"blastp_evalue": {"param_value": "1e-20", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "AbcA is a multidrug resistant ABC transporter that confers resistance to methicillin, daptomycin, cefotaxime, and moenomycin.", "model_sequences": {"sequence": {"3747": {"dna_sequence": {"fmax": "4775731", "fmin": "4771163", "accession": "NC_007194.1", "strand": "-", "sequence": "TCACTCGGCCTTTGCAACTGGCTTCTTGTCTCGTGGAACACGAACCCACCAGTACAGCGAACAAGCTGCAAAGATATTGAAAACAATAAATACCCACATGAGCCCAAAGTTCCTCCAGATATCCGAGTAACTCGACGAAACTCTACCGAGGAACACATTCGTCTCCTTGATCGGGCAGAAGCTGCAGTTCGCAGTCGCCATCTCGTCTGCAAGGTACCCGCCCAGATTCGACATGTATGAGCCCATGTACTCGCCGCAAGTCCCATTGACGGGGTCAAAGCGCAGATACTCATTGTCCGCGCAGGTGACATTCGTATTCGATATACCCACAGACAACATCCCGCTCACCAGATATGTAAACGGCGAAACGCGATACATGAAGATCCAGAACCGTGGGAGCTGATCCGGTGTCGCTAGCACGCCGCAGAAAAGCAGACAAAGCAGGAAAAGCAGGTTTCCGAGGTTTCCCGCGTTCTCGGCGGCGTCAAACGCTGCGATCATAAAATGGGCAAAGGTGGACGAGAAGAGAAGGAAGGTCCAGATCATCAGCCACATTTGCGTGCCCCGCAAGTGCACCGCATCAGTTGGTTCGGCATTGCGGTAAAGACCAATCGGGTAGTACCAGCACAGGAACATAAGGACGGACATGAGCGAGTTCCAGGGGAGTTCAACAACGATGTTGGCGATGAGGAAGGCTTTCCAAGAGTAGGTTTTTGCAGGTCGGTCGCGGACTTCATACAGCGCGCGCTGGGCGACGAAATGCGGCATGATTTGTTGGATAAGCTGGCCGAACAGGGTAAGTAGCATGAAGATGCCGAACATTTGATTCTGGAGGCCTTGGATGGTGTTGGGTGTATGGAAAAGGGAGAAGCCGACGAAGAGAGCGGATAACACGCAGAGAGCGGTCTTGGAGTAGATGTAGGTGGGTGACCGCCAGATTTGCTGGAAGACTCGTACTTGGACTTGGTAGAGCTGGGCCCAGAAAGGAGCAGCGAACTCGCGGTAGCTGTCTTTGTCTTCGCGCTTTTGGCCGGATGTAGTGCGGAACAGGTTTGTTTGGTGGCGACGTTCGTGTTTCAGTTCAGCAAGGTGCTCTTGGACTCGTGCATATTCGGGGGATCGACGCCAGGTCTCGAACCAGTTGATGCTGGTGTGTGATCCGGGAGCGGCACCGATCACATCCAGCATCCATTCGGCAGGATTCGCATCCGGAGGACATGGAGGGGCACCGTTGCGGACGAAGTAGTCAATCAGTATTTGCGAGTTCTGACCGATTTCTCCAAAGTAGACAGTACGACCCCCAGCTTGAAGGAAGAGGAGACGATCAAAGCGCTGAAACAGCATGGCAGATGGTTGATGGATGGTACACACTTGGAACACATTAATGACAGCGATAAACGCCGGATCAGACACTTACAAATAGCCTGGCCGTTCTTCTTCAGTTTATCGAGGAGATCAAGAATAGCCCAGGATGTCTGAGAATCAAGTCCTGAGGTCGGTTCGTCTAGGAAAAGGCTGCGCACGCAACATGATGCGCCTATCCCCGCAATGGGGACAAACGCAATACACTCAGTCAGTAATTTGCCCAAGGCCGCAGTAATTGCTGGAGGGCACAAACTTACAGGAGTTGGGGTCTGGCTGCAAGCTCTACCCCGATTGTGAGACGTTTACGTTGCTCAACGTTCAGGCCTTCACCAGGCACCCCAATAACGGCATCAGCATACTCCGTCATGTCAAGAAGCTTGATCACTTCTGTCACGTAGTCAATCTTCTCTTGACGAGGAACGTGAGCAGATTGACGTAGAAGAGCAGAGAACTCAAGTGCCTCGCGCACGGTAGCAGTACTCAAATGCAGATCTTGTTGCTGAGCATAGCCGGTCTTACGTTGAAAGGACTCATCACGCGGTTGACCATCGACGAGCATTTCTCCACTGATAATCCCCATCGTGGTGCGCGTAGCAAGGACATCCAAGAGCGTGGTCTTTCCAGCACCCGAAACACCCATAAGCGCCGTCAAGATTCCCGGTTTGACCCATCCGTCAACATGGTCAAGAATCCTGCAATTCTCCTTTCCAATCTTGATATCGAAGCAGACATCCTTCCACTGGAAGATTGCGGTTTGGCGTTCAATCATGGCAAGGCCATCTGAGCCGATCTTCTCGACTGTGGCGCTGCGGCCACCACCCCCTTCAAGATCCTCATCTGACTTGCCTTTCTTCAGAGCCTTGTGTCCGCGAGGAAATACCAGGATCTCGCCCTTCGGCTTCTTCTCGGTGATGAAGTCAGTAGCAACGAGATAGACCGCCCCAAGCAGGAACATGTAAGCGAATATGACACCGATGTTTCTCCATTTGTGAGAAGCGGTATAGCTATATGCTGACTCAATGTAAGCATTGCCATTGACAAAGGCTTGTCCAGGCACTGATCTGACGGTGGAGCAAACACGGTTGTTGAGCCCGACATCCGTATAGCCAGGACCCGATGGGACATAGTCCATGCACGGGAAATCGCGGTTGTGGAACTCATTGATCATCAGTGACTCAAAGCCATAGCTGATGGGATTGATGTACGCAATCCAGCGAGCCCAGCCCAGCATATATCCAGTCGGGATAGCGAACCCAGTGTACATGCTGAGACCGAGAAGTAGCACGGCGGAGAAGGGCAGAACTTGGACAAGGGATCTGGATAGCGATGCCATAGACCGGAAGAACATGGACATGGTCAGAGTCAGGATGAACGAAGTGAAGACAAAGAAGAAGAAAGCCCCGGGTTCTCTCCTCAAGTTGGTCATGAAGTACAGAACTATATTGGACGTAATGGCGTTGAGAATCTTATAGGGCAAATCCATTATCATTGATGAAAAAGCTTCAGCAGATGGATGGTAGAGAGCGTATCGGGAGTGCTTCTCGATGATCCCTCGTTGCGCGTATAGAGTCAGCATTTCAAGGCCGCAGCCAAGAGCGTTCATAAGAACAGCAAAGAAGAGAAGAGCACCACGCTGAAAAAAGGTGCTGGTGTCAGCCTTGAGGTTGTAGAAGATACTGGCGATAACTAGGGATATGATAGTATTTCCGAATAATGAAGAGATTGTGACACTGGGGTCAGCCTTCAATCGTTGATACCCGCGCCACAGGCACAGTTTCACCTGTTGGACATAGGAAAGAGTGTAGGGTGATGATACCCGCTGAGCCTTGGCTTGCTGGGCTCGCCGAGATTGCTTAAACTTATCCAGGTATTCCCCATCCAGTGCGAACTTTGCATTATAACTCTTGATGTGTTGCATCAGCTGTGCTCGCTGTGGTGAGGCCTTCCATCGTGCAGCGAACTCATCAGGTGTTCGAGGTACGCGATCTTCATAACCAGGCTGAACAACACGCTCAAGATGGCTAGTCATAGATGTGAGAAAGTCGGCATCGGTTTGCCGGTCAGGGCATACGAAGCCCATCTGAAGGAAGTAGTGCTTCGCCATGGATGTGGGACCAAAGTAGATCTCGCGACCTTCGTATAGGACCAGGACCTTATCGAAATAGTCGTACGCAGCCTGGGGAGCTTGATATAGAGAGACACAGGCTGTGGTGCCATTGATATCTGCCTGCATGCGTAAGGTTTTGCAGAACTCAATGGCATTCGCACTATCAAGACCACGAGTCGAATTGTCCCAACATTGCAGCGGTGCATTGCTGAGACAAGCTTCCGCAATGCTAACCCGCTTGCGCTCTCCACCAGATACACCGCGGATGAAGTCGTTTCCGACAATTGTGTTCTTCGTATGGCTGATACCAAACATGGCCATGATCACGTCTCGCATGTGGCCGGCATACTGGGTCGCATTCACCCCCCCAGGAATGTGTCGTGGTGTTCGGGCACGAGCCGCGAAATAAAGGGTATCTCCAACCGTGAGCTTGGGGAAGTGGACATCAACCTCTGCGGTATAGATGGCTTCACCCCTGAACTCGTGGGCCATCTGCTTTGCGCTCACGCCTGACCGAAATTAGCAAAGCAGCACCCTGCTCTTGTGTCAAGTTAAACATGCCTTGGAAATTGATGTTTGAGTTTTTGTCCACATGAAAGCCGTAAGTCTCTCCAGCAATGGTCTTCAAAAAAGTGGAGCATCCAGATCCAGGGGGTCCAAGTACGACGAGCATCTCTCCAGCCTCCACCAATCCTTCCAAGTTCTGCAAAATGTCGACTTTGCGCTGCTTTTGACCAAATGCTATTCTTGCCAGGCTGAGCGTCTTTAACCAGACATTGCCGACGCTTTTCTGGTAATCAGTGTCGGAACCGAAACCATGCACATTGAGATTGCTGAAGGCGACCCCCAAGGTTCGCAGTGGGTGTGCCTCCTTGTCCCCAATGTGCATCTGCAGCATGGCCTTGCACCATGCCCGAGCGTTGAAGCGTTCACCATTGGGGTCCAGGGCCGATCCGGCCTCCGCAGCAAAGGGGGTTTGTCCCGCCGTGGAATAGCTGCTCTGCTCTGTGAACTGTCTGGCTAGCCGAAGAACCTCCTCTTCCCTCTCCTCCACATTGGTAGAGGAATTTTTTCCAGCTTCATGACTTTCATTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Aspergillus fumigatus Af293", "NCBI_taxonomy_id": "330879", "NCBI_taxonomy_cvterm_id": "40696"}, "protein_sequence": {"GI": "XP_753111.1", "sequence": "MNESHEAGKNSSTNVEEREEEVLRLARQFTEQSSYSTAGQTPFAAEAGSALDPNGERFNARAWCKAMLQMHIGDKEAHPLRTLGVAFSNLNVHGFGSDTDYQKSVGNVWLKTLSLARIAFGQKQRKVDILQNLEGLVEAGEMLVVLGPPGSGCSTFLKTIAGETYGFHVDKNSNINFQGIAKQMAHEFRGEAIYTAEVDVHFPKLTVGDTLYFAARARTPRHIPGGVNATQYAGHMRDVIMAMFGISHTKNTIVGNDFIRGVSGGERKRVSIAEACLSNAPLQCWDNSTRGLDSANAIEFCKTLRMQADINGTTACVSLYQAPQAAYDYFDKVLVLYEGREIYFGPTSMAKHYFLQMGFVCPDRQTDADFLTSMTSHLERVVQPGYEDRVPRTPDEFAARWKASPQRAQLMQHIKSYNAKFALDGEYLDKFKQSRRAQQAKAQRVSSPYTLSYVQQVKLCLWRGYQRLKADPSVTISSLFGNTIISLVIASIFYNLKADTSTFFQRGALLFFAVLMNALGCGLEMLTLYAQRGIIEKHSRYALYHPSAEAFSSMIMDLPYKILNAITSNIVLYFMTNLRREPGAFFFFVFTSFILTLTMSMFFRSMASLSRSLVQVLPFSAVLLLGLSMYTGFAIPTGYMLGWARWIAYINPISYGFESLMINEFHNRDFPCMDYVPSGPGYTDVGLNNRVCSTVRSVPGQAFVNGNAYIESAYSYTASHKWRNIGVIFAYMFLLGAVYLVATDFITEKKPKGEILVFPRGHKALKKGKSDEDLEGGGGRSATVEKIGSDGLAMIERQTAIFQWKDVCFDIKIGKENCRILDHVDGWVKPGILTALMGVSGAGKTTLLDVLATRTTMGIISGEMLVDGQPRDESFQRKTGYAQQQDLHLSTATVREALEFSALLRQSAHVPRQEKIDYVTEVIKLLDMTEYADAVIGVPGEGLNVEQRKRLTIGVELAARPQLLLFLDEPTSGLDSQTSWAILDLLDKLKKNGQAILCTIHQPSAMLFQRFDRLLFLQAGGRTVYFGEIGQNSQILIDYFVRNGAPPCPPDANPAEWMLDVIGAAPGSHTSINWFETWRRSPEYARVQEHLAELKHERRHQTNLFRTTSGQKREDKDSYREFAAPFWAQLYQVQVRVFQQIWRSPTYIYSKTALCVLSALFVGFSLFHTPNTIQGLQNQMFGIFMLLTLFGQLIQQIMPHFVAQRALYEVRDRPAKTYSWKAFLIANIVVELPWNSLMSVLMFLCWYYPIGLYRNAEPTDAVHLRGTQMWLMIWTFLLFSSTFAHFMIAAFDAAENAGNLGNLLFLLCLLFCGVLATPDQLPRFWIFMYRVSPFTYLVSGMLSVGISNTNVTCADNEYLRFDPVNGTCGEYMGSYMSNLGGYLADEMATANCSFCPIKETNVFLGRVSSSYSDIWRNFGLMWVFIVFNIFAACSLYWWVRVPRDKKPVAKAE"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36611": {"category_aro_name": "tetracycline resistance gene", "category_aro_cvterm_id": "36611", "category_aro_accession": "3000472", "category_aro_description": "Genes conferring resistance to tetracycline antibiotics."}, "36590": {"category_aro_name": "gene modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Genes that directly or indirectly change rates of antibiotic efflux."}, "36241": {"category_aro_name": "fluoroquinolone resistance gene", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Genes conferring resistance to fluoroquinolones."}}, "ARO_name": "abcA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40695", "model_name": "abcA", "model_type_id": "40292"}, "2419": {"model_id": "2419", "ARO_accession": "3003945", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Doxorubicin resistance ATP-binding protein DrrB (DrrB) is the membrane protein part of the drrAB efflux pump.", "model_sequences": {"sequence": {"3750": {"dna_sequence": {"fmax": "3274075", "fmin": "3273205", "accession": "NC_000962.3", "strand": "+", "sequence": "ATGAGCGGCCCGGCCATAGATGCGAGCCCCGCCCTGACCTTCAACCAGTCAAGCGCGAGCATTCAGCAGCGACGCTTATCGACCGGGCGACAGATGTGGGTGCTCTATCGGCGTTTCGCCGCGCCGAGCCTACTCAACGGTGAAGTACTCACCACGGTGGGCGCGCCGATAATTTTCATGGTGGGCTTCTATATCCCGTTCGCCATACCGTGGAACCAATTTGTGGGTGGCGCCAGCTCGGGCGTCGCCAGCAACTTAGGGCAATACATCACGCCGTTGGTCACACTGCAGGCGGTCTCGTTCGCCGCGATCGGGTCGGGCTTTCGAGCCGCGACCGATTCGCTGCTAGGCGTCAATCGTCGGTTTCAGTCCATGCCGATGGCCCCGTTGACGCCACTGCTTGCCCGCGTGTGGGTGGCTGTGGACCGATGCTTCACGGGTTTGGTGATATCGCTAGTTTGCGGCTACGTCATCGGATTCCGTTTTCATCGCGGGGCCCTCTATATCGTCGGTTTTTGCCTACTGGTTATCGCGATCGGGGCTGTGCTGTCATTCGCCGCTGACCTGGTTGGCACCGTTACCAGGAACCCAGACGCGATGCTGCCGCTGCTGAGCTTGCCCATTTTGATCTTCGGACTGCTGTCCATTGGTCTCATGCCGTTAAAGCTGTTTCCGCACTGGATCCATCCATTTGTTCGCAACCAGCCGATCTCCCAGTTCGTCGCGGCGCTGCGGGCATTGGCCGGAGATACCACCAAGACAGCCTCACAGGTGAGTTGGCCTGTGATGGCTCCGACGTTGACGTGGTTGTTCGCTTTCGTGGTGATCCTGGCGCTTTCATCCACCATTGTTTTGGCTAGGCGGCCATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332", "NCBI_taxonomy_cvterm_id": "39507"}, "protein_sequence": {"GI": "NP_217453.1", "sequence": "MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "drrB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40700", "model_name": "drrB", "model_type_id": "40292"}, "2418": {"model_id": "2418", "ARO_accession": "3003944", "model_param": {"blastp_evalue": {"param_value": "1e-140", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump.", "model_sequences": {"sequence": {"3749": {"dna_sequence": {"fmax": "3273209", "fmin": "3272213", "accession": "NC_000962.3", "strand": "+", "sequence": "ATGCGCAACGACGACATGGCGGTGGTGGTTAACGGGGTTCGCAAGACCTACGGCAAGGGCAAGATTGTGGCCCTCGATGACGTGAGTTTCAAGGTGCGCCGCGGTGAAGTGATCGGGCTGCTGGGCCCCAACGGGGCCGGCAAGACGACCATGGTGGACATCTTGTCGACGCTGACCCGACCGGATGCCGGCTCGGCGATCATCGCTGGCTACGATGTTGTTTCCGAACCGGCCGGTGTACGCCGCTCGATCATGGTCACCGGGCAGCAGGTGGCCGTCGACGACGCGCTTTCCGGTGAGCAGAACCTGGTGTTGTTTGGTCGTCTGTGGGGACTGAGCAAGTCCGCGGCGCGCAAACGCGCCGCCGAACTGCTCGAGCAATTCAGCCTCGTACATGCCGGAAAGAGGCGGGTGGGCACCTACTCCGGCGGAATGCGCCGACGAATAGACATCGCGTGCGGATTGGTGGTCCAACCCCAGGTGGCGTTCTTAGACGAGCCCACCACCGGGCTCGATCCCAGGAGCCGGCAAGCTATTTGGGATCTGGTGGCCAGCTTCAAGAAGCTGGGCATTGCCACGTTGTTGACCACGCAGTATCTCGAGGAGGCGGATGCGCTCAGTGACCGCATCATCCTGATCGATCACGGCATAATCATCGCCGAAGGCACCGCGAATGAACTCAAGCACCGCGCCGGCGACACCTTCTGCGAAATAGTGCCCCGCGATCTGAAGGATCTGGACGCTATCGTCGCGGCGCTCGGTTCGCTGTTGCCCGAGCACCACAGGGCGATGCTGACGCCCGACTCAGACCGCATTACGATGCCGGCGCCTGACGGCATACGTATGCTCGTCGAGGCAGCGCGCCGGATCGACGAGGCGAGGATCGAGCTAGCCGATATTGCGCTGCGCCGACCGTCACTCGATCACGTATTCCTGGCCATGACGACCGATCCCACCGAGTCTCTGACCCATCTGGTGTCGGGGTCCGCGCGATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332", "NCBI_taxonomy_cvterm_id": "39507"}, "protein_sequence": {"GI": "NP_217452.1", "sequence": "MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFKKLGIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTESLTHLVSGSAR"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "drrA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40699", "model_name": "drrA", "model_type_id": "40292"}}}