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For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position-end position] eg. +S312. 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These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}, "107": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "104": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "105": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2047": {"$update": {"ARO_category": {"$update": {"36268": {"$update": 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"rifamycin resistance protein", "category_aro_description": "Enzymes, other proteins, or their products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "93": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "92": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "95": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "94": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "97": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "96": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1623": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products 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{"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "555": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "554": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "557": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam 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{"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "1758": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1756": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1755": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products 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{"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "514": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1579": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "1578": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to 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{"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "683": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1574": {"$update": {"ARO_category": {"$update": {"40016": {"$update": {"category_aro_name": "isoniazid resistance protein", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to the antibiotic drug, isoniazid."}}}}}}, "623": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer 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{"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "405": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1372": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1375": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, 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{"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1772": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1779": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1778": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam 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shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1151": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1150": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "1153": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1152": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam 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{"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1555": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "58": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "1557": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1556": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "55": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "54": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "57": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance 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{"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "52": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "537": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "536": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "535": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "534": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "533": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "532": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "531": {"$update": {"ARO_description": "SAT-3 is a plasmid-mediated streptothricin acetyltransferase and streptothricin resistance determinant. Originally described from an E. coli plasmid gene by Tietze and Brevet, 1995.", "ARO_category": {"$delete": ["37248"], "$insert": {"40980": {"category_aro_name": "nucleoside resistance protein", "category_aro_cvterm_id": "40980", "category_aro_accession": "3004027", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to nucleoside antibiotics, including aminonucleosides."}}}, "ARO_name": "SAT-3"}}, "530": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "539": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "1558": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "peptide antibiotic resistance protein", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to peptide antibiotics."}}}}}}, "428": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1399": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1398": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "421": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "420": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "423": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "422": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "425": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "424": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "427": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "426": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2183": {"$update": {"model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4672": "R:39355,R:39366,A:39390,A:39398,C:39377,C:36022,C:39384,A:39350"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "2182": {"$update": {"ARO_description": "Homologous to vanA, contains a D-Ala-D-Lac ligase.  This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin.Gene orientation: vanRSYHDX", "model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4674": "R:39357,R:39368,A:39391,C:39378,C:36014,C:39600"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "2181": {"$update": {"model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4676": "R:39359,R:39370,A:39392,A:39397,C:39379,C:39342,C:39386"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "2180": {"$update": {"ARO_description": "Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes.Gene orientation: vanL(XY)TmTrRS", "model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4680": "C:39344,C:39402,C:39407,C:39408,R:39361,R:39372"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "2186": {"$update": {"ARO_description": "Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes.Gene orientation: vanRSYWGYT", "model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4678": "R:39360,R:39371,C:39549,A:39399,C:39343,A:39393,C:39406,R:36714"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "229": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "2184": {"$update": {"model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4673": "C:36507,C:39400,C:39404,R:39356,R:39367"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "227": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "226": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "225": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "224": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "223": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "222": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "221": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "220": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2215": {"$update": {"ARO_category": {"$update": {"36631": {"$update": {"category_aro_name": "gene involved in self-resistance to antibiotic"}}, "36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "151": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "150": {"$update": {"ARO_category": {"$delete": ["36537"], "$insert": {"36191": {"category_aro_name": "phenicol resistance protein", "category_aro_cvterm_id": "36191", "category_aro_accession": "3000052", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}, "155": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "157": {"$update": {"ARO_category": {"$delete": ["37616"], "$insert": {"40990": {"category_aro_name": "diaminopyrimidine resistance protein", "category_aro_cvterm_id": "40990", "category_aro_accession": "3004028", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to diaminopyrimidine (incl. trimethoprim) antibiotics."}}}}}, "156": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2432": {"$update": {"ARO_category": {"$update": {"36409": {"$update": {"category_aro_name": "protein modulating permeability to antibiotic", "category_aro_description": "Enzymes or other proteins either directly or indirectly reducing overall permeability to antibiotics."}}}}}}, "2436": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}, "model_param": {"$insert": {"40334": {"param_value": {"4530": "nt41+5:GAGCA", "4529": "-DV244-245"}, "param_type_id": "40334", "param_type": "insertion / deletion", "param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position-end position] eg. +S312. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}, "2434": {"$update": {"ARO_category": {"$update": {"36409": {"$update": {"category_aro_name": "protein modulating permeability to antibiotic", "category_aro_description": "Enzymes or other proteins either directly or indirectly reducing overall permeability to antibiotics."}}}}}}, "1807": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1806": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1805": {"$update": {"ARO_category": {"$update": {"36268": 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{"36380": {"$update": {"category_aro_name": "lincosamide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to lincosamides."}}}}}}, "1492": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1493": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1494": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to 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{"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1995": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1395": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "tetracycline resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to tetracycline antibiotics."}}, "36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam 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{"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1013": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1234": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1235": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1236": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1237": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "rifamycin resistance protein", "category_aro_description": "Enzymes, other proteins, or their products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}, "model_param": {"$insert": {"40334": {"param_value": {"4081": "-517Q", "4054": "-527K", "4085": "-519N", "4050": "-520P", "4017": "+F514", "4006": "-N516", "4026": "-DQ516-517", "4027": "-QN517-518", "3999": "+R514"}, "param_type_id": "40334", "param_type": "insertion / deletion", "param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position-end position] eg. +S312. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}, "40394": {"param_value": {"4045": "Q513STOP", "4074": "S522STOP"}, "param_type_id": "40394", "param_type": "nonsense SNP", "param_description": "A SNP that changes an amino acid residue to a STOP codon resulting in a truncated protein product. These mutations are recorded in the format: [wild type amino acid][position][STOP] (e.g. Q42STOP)"}, "40330": {"param_value": {"4057": "S531L,S622A", "4062": "D516E,S522L", "4060": "H526Y,E541G", "4061": "D516Y,L511R", "4066": "S531L,H526C", "4067": "L511R,D516V", "4086": "H526D,S531", "4065": "S531L,F514V", "4068": "L511P,M515I", "4069": "L524W,T525P,H526Q,-527K", "4070": "Q513H,-514F,-515M,-516D", "4059": "H526S,P535H", "4058": "H526S,M515V", "4103": "T516I,G523W,D525Y", "4105": "H526P,K527Q", "4087": "L511P,S512T,D516V", "4108": "E562G,P564L", "4072": "-515M,-516D,-517Q,-518N", "4084": "-519N,S522L,S531L", "4104": "H526D,E541G,S553A"}, "param_type_id": "40330", "param_type": "multiple resistance variants", "param_description": "A parameter to describe the gene and the mapped mutation(s) within that gene. 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{"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2224": {"$update": {"ARO_category": {"$update": {"36409": {"$update": {"category_aro_name": "protein modulating permeability to antibiotic", "category_aro_description": "Enzymes or other proteins either directly or indirectly reducing overall permeability to antibiotics."}}}}}}, "2222": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2221": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to 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{"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "148": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "149": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2088": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2083": {"$update": {"ARO_category": {"$update": {"36631": {"$update": {"category_aro_name": "gene involved in self-resistance to antibiotic"}}, "36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "2080": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2086": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "tetracycline resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to tetracycline antibiotics."}}}}}}, "2087": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside 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{"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1830": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1831": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1836": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam 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"1956": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1951": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1950": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "rifamycin resistance protein", "category_aro_description": "Enzymes, other proteins, or their products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "1953": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other 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{"category_aro_name": "aminocoumarin resistance protein", "category_aro_description": "Point mutations to DNA topoisomerase enzymes clinically shown to confer resistance to aminocoumarins. 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For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position-end position] eg. +S312. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}, "40394": {"param_value": {"3835": "Q184STOP", "3908": "R3STOP", "3829": "Q22STOP", "3828": "R18STOP"}, "param_type_id": "40394", "param_type": "nonsense SNP", "param_description": "A SNP that changes an amino acid residue to a STOP codon resulting in a truncated protein product. 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{"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1846": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1845": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1844": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their 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{"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1901": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "854": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "855": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown 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shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "307": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "_timestamp": "2017-02-06T14:52:56+00:00", "2478": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "tetracycline resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to tetracycline antibiotics."}}}}}, "$insert": {"model_param": {"snp": {"param_type": "single resistance variant", "param_value": {"4758": "A965G", "4759": "A967C"}, "clinical": {"4758": "A965G", "4759": "A967C"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}, "40330": {"param_value": {"4761": "A965G,A967C", "4760": "A965G,G966U", "4762": "A965U,G966U,A967C"}, "param_type_id": "40330", "param_type": "multiple resistance variants", "param_description": "A parameter to describe the gene and the mapped mutation(s) within that gene. The parameter is described by the CVterm ID and the mutation(s) with format [wild-type][position][mutation], separated by commas."}}}}, "470": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "471": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1898": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1899": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "1895": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1896": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1890": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1891": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1892": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1893": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2136": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2137": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "elfamycin resistance protein", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to elfamycin antibiotics."}}}}}}, "2134": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2135": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2132": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2133": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "peptide antibiotic resistance protein", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to peptide antibiotics."}}}}}}, "2131": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "951": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "950": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "lincosamide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to lincosamides."}}, "36454": {"$update": {"category_aro_name": "macrolide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "streptogramin resistance protein", "category_aro_description": "Ezymes, other proteins or their products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "952": {"$update": {"ARO_category": {"$update": {"36547": {"$update": {"category_aro_name": "sulfonamide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to sulfonamide antibiotics."}}}}}}, "955": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "954": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2138": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "956": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "477": {"$update": {"ARO_category": {"$delete": ["36537"], "$insert": {"36191": {"category_aro_name": "phenicol resistance protein", "category_aro_cvterm_id": "36191", "category_aro_accession": "3000052", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}, "2002": {"$update": {"ARO_category": {"$delete": ["36537"], "$insert": {"36191": {"category_aro_name": "phenicol resistance protein", "category_aro_cvterm_id": "36191", "category_aro_accession": "3000052", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}, "2000": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2001": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2006": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2007": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2004": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2005": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2008": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2009": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "506": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1263": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "1262": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "919": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2177": {"$update": {"ARO_description": "This inducible cluster confers high resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. The vanA gene cluster can be located either on plasmids or on the chromosome.Gene orientation: vanRSHAXYZ", "model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4671": "R:39353,R:39365,C:39376,C:36019,C:39383,A:39389,A:39396"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "1799": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1798": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "719": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "718": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "717": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1792": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "715": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "714": {"$update": {"ARO_category": {"$delete": ["37616"], "$insert": {"40990": {"category_aro_name": "diaminopyrimidine resistance protein", "category_aro_cvterm_id": "40990", "category_aro_accession": "3004028", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to diaminopyrimidine (incl. trimethoprim) antibiotics."}}}}}, "1797": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "lincosamide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to lincosamides."}}, "36454": {"$update": {"category_aro_name": "macrolide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "streptogramin resistance protein", "category_aro_description": "Ezymes, other proteins or their products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1796": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "711": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "710": {"$update": {"ARO_category": {"$delete": ["37616"], "$insert": {"40990": {"category_aro_name": "diaminopyrimidine resistance protein", "category_aro_cvterm_id": "40990", "category_aro_accession": "3004028", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to diaminopyrimidine (incl. trimethoprim) antibiotics."}}}}}, "1265": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "716": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "505": {"$update": {"ARO_category": {"$delete": ["36607"], "$insert": {"40134": {"category_aro_name": "polyamine resistance protein", "category_aro_cvterm_id": "40134", "category_aro_accession": "3003532", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to polyamine antibiotics."}}}, "model_param": {"$insert": {"40334": {"param_value": {"3531": "98+1:A", "3532": "79+1:T"}, "param_type_id": "40334", "param_type": "insertion / deletion", "param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position-end position] eg. +S312. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}, "40394": {"param_value": {"3530": "Q351STOP"}, "param_type_id": "40394", "param_type": "nonsense SNP", "param_description": "A SNP that changes an amino acid residue to a STOP codon resulting in a truncated protein product. These mutations are recorded in the format: [wild type amino acid][position][STOP] (e.g. Q42STOP)"}}}}}, "2178": {"$update": {"model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4682": "R:39364,R:39375,C:39382,C:39347,C:39388"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "1069": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1068": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2179": {"$update": {"model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models."}, "$insert": {"model_param": {"40297": {"param_value": {"4679": "C:39341,C:39401,C:39405,R:39358,R:39369"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}}}, "1061": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1060": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1063": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "1062": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam 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{"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "1668": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1667": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1666": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products 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{"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1084": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1083": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "594": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "1081": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "596": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "599": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "598": {"$update": {"ARO_category": {"$delete": ["37616"], "$insert": {"40990": {"category_aro_name": 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{"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "124": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "125": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "126": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance 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These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}, "1299": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1292": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1561": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "1562": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1291": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1296": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1297": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1566": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "1295": {"$update": {"ARO_category": {"$delete": ["36537"], "$insert": {"36191": {"category_aro_name": "phenicol resistance protein", "category_aro_cvterm_id": "36191", "category_aro_accession": "3000052", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}, "1713": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "glycopeptide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to glycopeptides."}}}}}}, "474": {"$update": {"ARO_category": {"$delete": ["37616"], "$insert": {"40990": {"category_aro_name": "diaminopyrimidine resistance protein", "category_aro_cvterm_id": "40990", "category_aro_accession": "3004028", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to diaminopyrimidine (incl. trimethoprim) antibiotics."}}}}}, "796": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "rifamycin resistance protein", "category_aro_description": "Enzymes, other proteins, or their products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "1361": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "795": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1381": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1710": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}, "793": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "792": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "791": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "790": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "472": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "473": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "macrolide resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "1364": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1365": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1362": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1363": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1360": {"$update": {"ARO_category": {"$update": {"36616": {"$update": {"category_aro_name": "aminocoumarin resistance protein", "category_aro_description": "Point mutations to DNA topoisomerase enzymes clinically shown to confer resistance to aminocoumarins. In some cases, expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can also confer aminocoumarin resistance."}}}}}}, "475": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "478": {"$update": {"model_sequences": {"$update": {"sequence": {"3891": {"dna_sequence": {"fmax": "16478", "fmin": "15617", "accession": "NC_020088.1", "strand": "+", "sequence": "ATGCATACGCGGAAGGCAATAACGGAGGCGCTTCAAAAACTCGGAGTCCAAACCGGTGACCTCTTGATGGTGCATGCCTCACTTAAAGCGATTGGTCCGGTCGAAGGAGGAGCGGAGACGGTCGTTGCCGCGTTACGCTCCGCGGTTGGGCCGACTGGCACTGTGATGGGATACGCGTCGTGGGACCGATCACCCTACGAGGAGACTCTGAATGGCGCTCGGCTGGATGACGAAGCCCGCCGTACCTGGCTGCCGTTCGATCCCGCAACAGCCGGGACTTACCGTGGGTTCGGCCTGCTGAATCAATTTCTGGTTCAAGCCCCCGGCGCGCGGCGCAGCGCGCACCCCGATGCATCGATGGTCGCGGTTGGTCCGCTGGCTGAAACGCTGACGGAGCCTCACGAACTCGGTCACGCCTTGGGGGAAGGATCGCCCGTCGAGCGGTTCGTTCGCCTTGGCGGGAAGGCCCTGCTGTTGGGTGCGCCGCTAAACTCCGTTACCGCATTGCACTACGCCGAGGCGGTTGCCGATATCCCCAACAAACGGTGGGTGACGTATGAGATGCCGATGCTTGGAAGAGACGGTGAAGTCGCCTGGAAAACGGCATCGGATTACGATTCAAACGGCATTCTCGATTGCTTTGCTATCGAAGGAAAGCCGGATGCGGTTGAAACTATAGCAAATGCTTACGTGAAGCTCGGTCGCCATCGAGAAGGTGTCGTGGGCTTTGCTCAGTGCTACCTGTTCGACGCGCAGGACATCGTGACGTTCGGCGTCACCTATCTTGAGAAGCATTTCGGAACCACTCCGATCGTGCCTCCGCACGAGGCCGTCGAGCGCTCTTGCGAGCCTTCAGGTTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"GI": "YP_007349693.1", "sequence": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG"}}}}}, "ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "479": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "beta-lactam resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1369": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}}}}}}, "$delete": ["2238", "2237", "2236"], "$insert": {"2525": {"model_id": "2525", "ARO_accession": "3003989", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "AAC(6')-34 is an aminoglycoside 6'-phosphotransferase found in Paenibacillus sp. LC231, a strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3861": {"dna_sequence": {"fmax": "594", "fmin": "0", "accession": "KX531053.1", "strand": "+", "sequence": "ATGAGAATTGGGGATCTAATAAGGGAAGATGGGGGGATCGCGATGCTGGTGTACGAGGCTGGACCGATTACGGTTCGCGAGCTGGAGGAGAAGGATGAAATATCCTTAGCTTCTTGGCTGTCCAATCCGGATGTGCTGCAGTATTATGAGGGACGGGACAATCCTCACGACGTGGAGCGGGTGCGGGAGCATTTTTACGTGGATGATGATGAGACTCGCTGCATCATTAAATATGAGGGGAAACCGATCGGATATATTCAGTTTTATCTTCTGGATGAAGAGACGTTAGGCGAGTATGGATATAACGAGAGTGATGCAGACTGCAGAACCTTCGCCACGGATCAATTCATCGGGGAGCCGGATTATTGGAATCGAGGCATCGGTACGAAGCTCATGACTTCCATGGTGGAGTATCTCGTGTTTCAGAGGCAGGCTGATCGGATCGTAATGGACCCGCAGGCATGGAATGAACGGGCGATTGCTTGTTACGAAAAGTGCGGCTTCCGGAAGGTCAGACTGCTGGAGAAGCATGAACAGCATGAAGGTGAACTGCGGGACTGCTGGATTATGGAGTATCGGGCAGAGCGAAAGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03223.1", "sequence": "MRIGDLIREDGGIAMLVYEAGPITVRELEEKDEISLASWLSNPDVLQYYEGRDNPHDVERVREHFYVDDDETRCIIKYEGKPIGYIQFYLLDEETLGEYGYNESDADCRTFATDQFIGEPDYWNRGIGTKLMTSMVEYLVFQRQADRIVMDPQAWNERAIACYEKCGFRKVRLLEKHEQHEGELRDCWIMEYRAERK"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36243": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}, "ARO_name": "AAC(6')-34", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40871", "model_name": "AAC(6')-34", "model_type_id": "40292"}, "2524": {"model_id": "2524", "ARO_accession": "3003988", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "AAC(2')-IIb is an intrinsic Kasugamycin 2' acetyltransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics, including kasugamycin. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3860": {"dna_sequence": {"fmax": "723", "fmin": "0", "accession": "KX531051.1", "strand": "+", "sequence": "ATGAACCATAGGAAAGGTAACGAGCCAACCGCTGCGGCACTGATGGAATTGCATGTTCTGGCGATGTTTACGCATGACGGGAATATGCAAATTCGCACCATCAACGAGCCTTGGCCGGGAGAGGAGCTTGCCCCGAGGTTTTTCATGGGTCGAACGATAGACGGCTCTTCGATCTGCAGGTTTCGTCATGATGTTCCCGAAGGAATTGCCGGGCAATTGAGGGCTTTGGTTGAAGATGAGCCTATCGTTACTGAAGAGGTTCTGACGAGGCCTAAACATTTTGCAGCTTATATGAACCTCCTTCGCGCTGAGCACTATACGAGCGGACCTTGTTATCGGATACCTGATCAAACAACGCAGGCCAAACAGACGGTAAGGATCACACCGGGAAATATTCGCGAATATTCGCTCACCGGTTTTGAATGGCTGACCACGGAAATTGATTATGACCAGCCTTGTGTTGCGCTCATTCATGAGAATAGGGTGGTGTCGGTTTGCCGCAGCGTCCGGATTACTGAACGAGCTCACGAAGCTGGGCTTGAAACGTCAGAGGAATTTCGTGGAAGAGGTTATGCGGCTGCTGTTGTTGCCGGATGGGCCATAGAGGTGCAAAAAATGGGCGCGCTGGCGTTGTACAGTACTTTATGGGGAAATAGCTCTTCCCGGAGAGTAGCAAATAAATTAGGGTTGTCCTATTACGGAGTTAACTTCACGATCAGTTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03221.1", "sequence": "MNHRKGNEPTAAALMELHVLAMFTHDGNMQIRTINEPWPGEELAPRFFMGRTIDGSSICRFRHDVPEGIAGQLRALVEDEPIVTEEVLTRPKHFAAYMNLLRAEHYTSGPCYRIPDQTTQAKQTVRITPGNIREYSLTGFEWLTTEIDYDQPCVALIHENRVVSVCRSVRITERAHEAGLETSEEFRGRGYAAAVVAGWAIEVQKMGALALYSTLWGNSSSRRVANKLGLSYYGVNFTIS"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36243": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}, "ARO_name": "AAC(2')-IIb", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40870", "model_name": "AAC(2')-IIb", "model_type_id": "40292"}, "2527": {"model_id": "2527", "ARO_accession": "3003991", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "mphI is a macrolide phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to macrolide antibiotics. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3863": {"dna_sequence": {"fmax": "927", "fmin": "0", "accession": "KX531056.1", "strand": "+", "sequence": "ATGACAATAGCAAAACCAAATGATGATTATACACAAGTGATCCAAGAGATGCTGGAGATTGCCGGAAAACACGGGGTGAATTTGATTCCGGAGGGAATAGAGATGAATGAATCCGGCATGGATTTCCTTGTTGGATTCGCAGAGGAGGCAGGGACTGGAGCACGGTGGATTCTGCGGAAACCGAGACGACCGGATGTGCTGGATAGAGCAGATAACGAAGCTAGGGTCCTGAAGCTGATTCAATCCCATCTTTCGGTTGATGTACCGGATTGGCGGATTTACACGCCGGAGCTCATCGCCTATCCGCTGCTTAGCGGGCAGCCTGCCGCTTCCGTCAGCATGGAAGGATATGCATGGAATATGGATCATGAGAATCCGGGCGACGGGTTTATCCGCTCACTGGCTGAAGCGCTGGTTGCCTTGCATGGCGTCGATCATGATGCAGCCCGAGCAGCAGGTCTGCGGGTAAAGAGTCCCCAAGAGGTTCGTGATGAGACGGCGCGAAATATGGAAGACATCAAGAGCCGTCTGGGCGTTTCCGATGCGCTGTGGGAGAGATGGCAAAAATGGCTGGAGGAGGATTCCTATTGGCCGACGCATTCTGCCCTCATCCATGGCGATCTTCATCCCCCGCATATCCTGATTGATGAGCGCGTGCAGGTGACCGGACTTTTGGATTGGACGGAGTCCGAGGTAGCAAGTCCCGCCAAAGACTTCGTGTTATACTACGCTATTTATGGCGAGCATAATCTCCGTGTCCTGTTGGACCGGTATGAACAAGCCGGAGGGAAGGTATGGCCGCGCATGTTCGATCATATTGTCGAACAGCATGCCGCGTATCCCGTGCTGATCGCCCAGTTCGCTCTCCTGACAGGCCAGGAAGAGTATATGACGATGGCGCGGAATGCTCTGGGTTTGACGGAGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03226.1", "sequence": "MTIAKPNDDYTQVIQEMLEIAGKHGVNLIPEGIEMNESGMDFLVGFAEEAGTGARWILRKPRRPDVLDRADNEARVLKLIQSHLSVDVPDWRIYTPELIAYPLLSGQPAASVSMEGYAWNMDHENPGDGFIRSLAEALVALHGVDHDAARAAGLRVKSPQEVRDETARNMEDIKSRLGVSDALWERWQKWLEEDSYWPTHSALIHGDLHPPHILIDERVQVTGLLDWTESEVASPAKDFVLYYAIYGEHNLRVLLDRYEQAGGKVWPRMFDHIVEQHAAYPVLIAQFALLTGQEEYMTMARNALGLTE"}}}}, "ARO_category": {"36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36454": {"category_aro_name": "macrolide resistance protein", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to macrolide antibiotics."}}, "ARO_name": "mphI", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40873", "model_name": "mphI", "model_type_id": "40292"}, "2526": {"model_id": "2526", "ARO_accession": "3003990", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "VgbC is a streptogramin B lyase found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin B antibiotics. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3862": {"dna_sequence": {"fmax": "891", "fmin": "0", "accession": "KX531055.1", "strand": "+", "sequence": "ATGCAGATCGCCGCACAGGAGTACAAGACAGCGAATCGGGAATCGGGACCTTATGGTATTACGGCAAGACAAGATCGGACCATATGGTTCACGGAACAAAAAGGAAACCGGATCGGACGGCTCACCAAGGATGGGGATATGCGCACGTTCGAAGTGCCGACTCCAGATGCCGGGGTCATGTCTATCCTCTCTGCCCATACCGGTGACCTCTGGTTTACGGAGTACAAAGCAAATAAAATCGGAAGGATGACAATGGAAGGAACATTTGCGGAATTCGAGCTGCCTGAAGCCAATTCGTCTCCCTACGGCTTGGCTGAGGGTCCGGATGGAGCCATATGGTTCACCGAGCTAAGCGGCAACCGAATCGGAAGGATAACGCCGGCAGGCATTATCACGGAATATGACTTACCATGCGAAGGATCGTACCCTTCCTATATTACAGCCGGTCCGGACGGCGCGTTGTGGTTTACGGAAAACCAGAACAACTGCATCGGCCGAATTACGGTGGACGGGGAGATTACCGAGTACCGGATTCCAACAGAGCAATCCGGGCCGGTCGGCATCACGACAGGTGCCGATGGCGCTCTATGGTTTGTTCAAATCAACGGCAATCAAATCGGCCGGATCACAACGGCCGGGGAAATTACGGAATTCAAGCTCCCGTCCGGGAATGCCAGACCCCATGCCATCACGGCGGGCGTTTCCGGGGATCTATGGTTTACCGAATGGGGAGCCAATCAAATCGGACGAATTACCTGCACCGGGGACATTACCGAGTATCCAATCCCTACCCCCTCCGCAGAACCTCATGGCATAACCGTGGATTCGGGCGGCGAGGTCTGGTTCGCCGAGGAATGCGATCAGATCGGCCGGTTTACGATTCAGTATTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03225.1", "sequence": "MQIAAQEYKTANRESGPYGITARQDRTIWFTEQKGNRIGRLTKDGDMRTFEVPTPDAGVMSILSAHTGDLWFTEYKANKIGRMTMEGTFAEFELPEANSSPYGLAEGPDGAIWFTELSGNRIGRITPAGIITEYDLPCEGSYPSYITAGPDGALWFTENQNNCIGRITVDGEITEYRIPTEQSGPVGITTGADGALWFVQINGNQIGRITTAGEITEFKLPSGNARPHAITAGVSGDLWFTEWGANQIGRITCTGDITEYPIPTPSAEPHGITVDSGGEVWFAEECDQIGRFTIQY"}}}}, "ARO_category": {"36379": {"category_aro_name": "streptogramin resistance protein", "category_aro_cvterm_id": "36379", "category_aro_accession": "3000240", "category_aro_description": "Ezymes, other proteins or their products shown clinically to confer resistance to streptogramin antibiotics."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}, "ARO_name": "VgbC", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40872", "model_name": "VgbC", "model_type_id": "40292"}, "2521": {"model_id": "2521", "ARO_accession": "3003984", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Bacitracin amidohydrolase found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance by bacitracin inactivation through amidohydrolysis. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3857": {"dna_sequence": {"fmax": "2259", "fmin": "0", "accession": "KX531048.1", "strand": "+", "sequence": "TTGGAAATACACAAAGAGAAAGAAAAAGAAAAAGGCGTTACGTTTTTTCGAAGAATCATGGCAAACCGGAAGCGTAGGGGGCCGCTATCCCCTGGATGGAAGGGTGCGTCGCTTGGGCTCGGCGCCACCGGCTTTATTCTAATTCTGATACAGGCCAATTATCTATTGACGGGGCATGGTGTCGGTAAATTCATCGTGGGCACATTCCTGTTTCTCTTTGCGGCTGCCCTTATAAGCGGCCTAGCATCAATGTTGCTGCACGGGGTCAAGAAACTACCAAGCCGTTATATTTGGATGCTGCTGTATTCCCTGATCATGTTTTTATTCTGTTTTATTGTGCAGCCGGGCGTATCGGCAGTCTTCATCGTCTCTTTGGCCATTGTTTTATCTTTATTTGGTGCATTGGCTTATAAATTTGCAGCGGGAAGCTACAAGCAAGTGTCTAAAACCAGGAAAATCGGCGCGATGGCTTGTTTGTCCTTGATCACCATCGCGATCGGCGCTGGCAGCTTCTGGCTGATTCGGGCCGGAGATGATGCCGCTCCGGACATCACATTGAAACAGCTGAAAACCTCAACCCGATATGAAGACTCGACGATGAACAATCCGGCCGAACAAGGCACATATCCCGTCCAAAGCCTGTTATACGGAAGTCCTGACAACTATCGGACAGAATTTAATCAAAGCGGTTCCCTAACCACCCAAACGGTGGATGCGTCCAGGTTTGTTGAGAAGTGGTCGTCTTTGCGCACGAAGTCGCTTGGATTCGGACCCGAGGCCATGCCGTTAAACGGAAGAGTGTGGTATCCCGAAGGGGAAGGCACCTTTCCGCTTGTTTTGATTGTACATGGTAATCACTTGATGAATGATTATTCCGATCCGGGTTATGAATATCTCGGCAGGCTGCTCGCGAGCAAAGGGTATATATTTGTCTCCGTGGATGAAAATTTCCTCAATTTCTCCCCATATGAGGATCTATTCCTGATCAGCCCGCTGCTAAGTGAAAATCCGGCAAGGGGTCTGCTGCTGCTGGAGCATTTGCAAACCTGGAAGGACTGGAACAGCGATCCGGACAACCCGTTTTACCAAAAGGTCGATATGGAACGAATCGCCCTCATCGGTCATTCCCGGGGCGGCGAAGCGGTCGCGATCGCGGCAGCGTATAACAAGCTTGGCCGTCATCCGGACCATGGGGATATCAAGTTTGATTATAACTTTTCGATCCGCTCGCTCATTTCCATTGCGGGAACGGACGGGCAATATAAGCCCCAAGGCAAACCTCTGCCGCTGCAAGACGTAAATTATCTGTCTTTGCATGGAGCTCATGATATGGATGTCAACAGCCTGGACGGTGCGAAGCAATATCACCGGATTCGTTATACCAAGGGCACAAATTACATGAAATCGCTGGTCTATATTTATGGAGCCAACCACGGCCAGTTTAACGGAGGCTGGGGCAGAGGGGATGGGGCAGGGTTGGGGAACCAACTGTTTAACCTACGTCAAATTATGCCACGGGATGAGCAGGAAACCATCGCAAAAGTGTTCATATCTTCGTTCCTGGATGCCACGCTGAAGGACCAACGGCAATACAGGGAGGTGTTCAAGGATTTGGGTTACGCCAAGGAATGGATTCCCGACAATCTGTATGTGGGCAATTATTACGATTCGCAGACGACCTTGATCGCCGATTTTCATGAAGACATCGATCTGCAGAGCACCACGCTTCCTGGCGGCAGCCTGCGGGGCGAGAACCTGCAGCAATGGAAGGAAGAAAAGGTTAAGACAAAATGGGGCGAAGCGGATTACAGCGCGGTTCGCTTAGGCTGGAATTCGAACGGTTCGTCCGAGCCTGCCTCCTATACGGTTACTTTGCCGGATAACGGGGTGGAAACAGGAAGGGATAGCTCGATCGTATTTTCGCTGGCAGATGCACGCAAAACAGAAGAAAGCGGCGACCCGAAAGAGCTTATCAATTTTACGATTACGGTTGAAGATAGGAAGGGCCATCAGGCAAGTCTTCCCCTCAGCCACATATCCAAGTTGCCGCCTGTTATTGAAGGTAAACTTCTCAAATGGCCATTTTCGAATGCAGGCAATACTTCAGAACCCGTATTTCAAAGCTACGATTTCCAATTAGACGATTATTACAAAATGAATCCGGACTTCAACCCGCAGCAGTTGAGCAAGATTCGCATCGAGTTCAATCTAACCAAGCGGGGAAGCATTCTGCTTCGTGATGTTGGCATTCGATCTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03218.1", "sequence": "MEIHKEKEKEKGVTFFRRIMANRKRRGPLSPGWKGASLGLGATGFILILIQANYLLTGHGVGKFIVGTFLFLFAAALISGLASMLLHGVKKLPSRYIWMLLYSLIMFLFCFIVQPGVSAVFIVSLAIVLSLFGALAYKFAAGSYKQVSKTRKIGAMACLSLITIAIGAGSFWLIRAGDDAAPDITLKQLKTSTRYEDSTMNNPAEQGTYPVQSLLYGSPDNYRTEFNQSGSLTTQTVDASRFVEKWSSLRTKSLGFGPEAMPLNGRVWYPEGEGTFPLVLIVHGNHLMNDYSDPGYEYLGRLLASKGYIFVSVDENFLNFSPYEDLFLISPLLSENPARGLLLLEHLQTWKDWNSDPDNPFYQKVDMERIALIGHSRGGEAVAIAAAYNKLGRHPDHGDIKFDYNFSIRSLISIAGTDGQYKPQGKPLPLQDVNYLSLHGAHDMDVNSLDGAKQYHRIRYTKGTNYMKSLVYIYGANHGQFNGGWGRGDGAGLGNQLFNLRQIMPRDEQETIAKVFISSFLDATLKDQRQYREVFKDLGYAKEWIPDNLYVGNYYDSQTTLIADFHEDIDLQSTTLPGGSLRGENLQQWKEEKVKTKWGEADYSAVRLGWNSNGSSEPASYTVTLPDNGVETGRDSSIVFSLADARKTEESGDPKELINFTITVEDRKGHQASLPLSHISKLPPVIEGKLLKWPFSNAGNTSEPVFQSYDFQLDDYYKMNPDFNPQQLSKIRIEFNLTKRGSILLRDVGIRS"}}}}, "ARO_category": {"37131": {"category_aro_name": "peptide antibiotic resistance protein", "category_aro_cvterm_id": "37131", "category_aro_accession": "3000751", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to peptide antibiotics."}}, "ARO_name": "BahA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40866", "model_name": "BahA", "model_type_id": "40292"}, "2520": {"model_id": "2520", "ARO_accession": "3003983", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Chloramphenicol acetyltransferase conferring resistance to phenicol antibiotics detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3856": {"dna_sequence": {"fmax": "654", "fmin": "0", "accession": "KX531047.1", "strand": "+", "sequence": "ATGAAGTTTCACATTATTAATGTTGAAGAGTGGACGAGAAAGCCTTATTATGAGCATTATCTTCGATCGAATAAATGCACCTTCAGCATCACCGTGGATATCGACATTACTCGCTTGTTGTATTCGTTAAAAGCTAATGGATTCAAGCTTTATCCAGCTTTTATTTATATGGTTACAAGAGTTGTCAATGACCGGGTTGAATTCAAAACTTCCTTTAGTCCCGAAGGGGAATTGGGTTACTGGGATCGGATGACGCCGAGTTATACCTTTTTCCATAACGATGACCATACCTTCTCCTGTTTATGGACAGCATTTTCGAATGATTTCTATCGATTTCATGATCATTACGAGCAGGACATGGAGCAATATCGGGATACAAAAGGGCTGTTTGTTAAAGAGAATCCACCGCCGAACACGTTTCCCATATCCATGATACCCTGGACAAGCTTTAGCGGATTTAATCTAAACATTGTCAATGAAGCAGACTATCTTCTTCCCATCATAACCGGCGGAAAATATACCGAGCAGGGTGGCCGTGTTCTGCTTCCAGTCTCATTGCAGGTGCACCATGCTGTGTGTGATGGTTATCATGCCAGCATGTTCTTTAAGGAGTTGCAGAGCTTGGCGGATTCTTTTGAAGATTGGTTAACTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03217.1", "sequence": "MKFHIINVEEWTRKPYYEHYLRSNKCTFSITVDIDITRLLYSLKANGFKLYPAFIYMVTRVVNDRVEFKTSFSPEGELGYWDRMTPSYTFFHNDDHTFSCLWTAFSNDFYRFHDHYEQDMEQYRDTKGLFVKENPPPNTFPISMIPWTSFSGFNLNIVNEADYLLPIITGGKYTEQGGRVLLPVSLQVHHAVCDGYHASMFFKELQSLADSFEDWLT"}}}}, "ARO_category": {"36191": {"category_aro_name": "phenicol resistance protein", "category_aro_cvterm_id": "36191", "category_aro_accession": "3000052", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}, "ARO_name": "CatU", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40865", "model_name": "CatU", "model_type_id": "40292"}, "2523": {"model_id": "2523", "ARO_accession": "3003987", "model_param": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Streptogramin A acetyltransferase found in Paenibacillus sp. LC231, isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin A antibiotics. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3859": {"dna_sequence": {"fmax": "633", "fmin": "0", "accession": "KX531050.1", "strand": "+", "sequence": "ATGACAGGACCGAATCCAAATGAGAGATATCCTATACCCGGAGATAACAATCTTCAGTTTATCAAGAACACGATTACAAAACCTAATATTATCGCAGGGGATTATTCATACTACTATGCCTTAAACGGAGAATCATTTGAGGATCAAGTATTGTATCATTATGAATTCATTGGAACTAAATTAATGATCGGCAAGTTTTGTTCCATTGCTTCCGAGGTCAGATTTATGATGGATGGAGGGAACCATCGGATGGACGGTTCAACCTTTCCATTTAATATCTTTGGAAACGGCTGGGAGAAATTCACTCCATCTTTGGATCAATTGCCGATCAAGGGAGATACGATCATTGGAAATGACGTGTGGATCGGAAGGCGTGCAACGATCATGTCGGGTGTAAGGATTGGCGATGGAGCTATCATTGCCGCTGAAGCTGTCGTTGTAAAGGATGTGGAGCCTTATACGATCGTTGGAGGCAATCCAGCGAAGGATATCCGCAAGCGATATTCCACCGAAGTCATTCAAGAGTTATTGGATATTAAATGGTGGGATTGCGATATCGAAGTCATCAATCAATATATTGGCGCAATTGTAAGCGGAGATATGGACTTGCTTAGAAAAATGAGACAAAATTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03220.1", "sequence": "MTGPNPNERYPIPGDNNLQFIKNTITKPNIIAGDYSYYYALNGESFEDQVLYHYEFIGTKLMIGKFCSIASEVRFMMDGGNHRMDGSTFPFNIFGNGWEKFTPSLDQLPIKGDTIIGNDVWIGRRATIMSGVRIGDGAIIAAEAVVVKDVEPYTIVGGNPAKDIRKRYSTEVIQELLDIKWWDCDIEVINQYIGAIVSGDMDLLRKMRQN"}}}}, "ARO_category": {"36379": {"category_aro_name": "streptogramin resistance protein", "category_aro_cvterm_id": "36379", "category_aro_accession": "3000240", "category_aro_description": "Ezymes, other proteins or their products shown clinically to confer resistance to streptogramin antibiotics."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}, "ARO_name": "VatI", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40869", "model_name": "VatI", "model_type_id": "40292"}, "2522": {"model_id": "2522", "ARO_accession": "3003986", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Pleuromutilin (Tiamulin) ABC efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to pleuromutilin antibiotics. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3858": {"dna_sequence": {"fmax": "1947", "fmin": "0", "accession": "KX531049.1", "strand": "+", "sequence": "ATGAATATTTTGACCGTCGAACAGGTAACAAAAAGCTATGGAGACAAAATTCTGTTTCAAGATGCATCCTTCGGAATGGAGGATCAGGATAAAATCGGCATTATCGGCGTGAATGGCACGGGGAAATCCACATTTCTGCGGGTCATCGCGGGGCTCGAGCCGCCCGACTCCGGTAAAATATCGATGGGCAATCGCATCCGGGTTCGTTACCTCGCGCAAAATCCGGAGTTTGATCCGGACAAAACCGTCCTGCAGCAGGTGTTTGAGGGCGATCTTCCGGAGATGAAGGCCGTGCGGGAATACACCGAAACGATGGAACTGCTGGAGCTGCATCCAAGTCATGAGGAGCTCCAGCAGAAACTGCTGAAGCTCAATCAGACGCTGGAAACGCTGCAGGCATGGCAGCTTGAAAGCGATGCGAAAACCATCCTGTCCAAGCTGGGGATTCGGAATTATGAAGCGAAGATGGGAACGCTGTCGGGCGGCCAGCGTAAGCGGGTGGCATTAGCCGCCGCCTTGATTCAGCCTTCCGACTTGCTTATTTTGGACGAGCCGACCAACCACATTGACAATGAATCCGTTGCCTGGCTGGAGCAGTATTTGCAGAAGCGCCGCGGCGCGCTGCTCATGATTACGCATGACCGGTATTTTCTGGACCGGGTAGCCAATGTTATGCTGGAGCTGGATCACGGACGGCTGTTTCGATATGAGGCGAACTACAGCCGTTTTCTGGAGCTGAAGGCAGAACGCGAGGAGCGTGAAGCCGCTTCCGAGCAAAAGCGCCAAAATTTGCTGCGGAGCGAGCTTGCCTGGATCCGCAGAGGGGCCAAGGCCCGCACGACCAAGCAGAAGGCGAGGATTGAACGCTTCGAGAAACTCAAGGATCAGGAGATGGTGCACAGCTCCGGTGAACTGGACGTTTCGGTCGCTTCCACCCGCTTGGGACGCAAAATTCTGGAGATTGAAGGTCTCCGGATGAAGATCGACGACAAAACGTTAATTCAGGACCTTTCCTATATCGCCGTTCCCGAGGATCGGATAGGTATCGTAGGCCCGAACGGCAGCGGCAAATCCACGCTGCTCAATCTGATTGCCGGGCGGATTCAGCCGGGTGGCGGGGAAGTCGTGCTCGGACCGACGGTCAAGCTCGGTTATTTCACGCAGGAGCATCAGGAGATGGACGGCAGTCAGCGCGTGATTGAGTATATCAAGGATGAGGCCGAGGTTGTCCGCACGGCGGACGGTTCGGCGATTACCGCAGCCCAGATGCTGGAACGCTTTCTGTTCCCGCCCGCGCTGCAGTGGACGCCGATTGCGAAGCTGTCCGGAGGCGAGAAGCGCCGCTTGTATCTGCTGCGGGTGCTGATGAGCGCACCGAATGTGCTGCTGCTTGATGAACCGACCAATGATTTGGATATCCAGACATTGTCCGTCCTGGAGCAGTATTTGGATGAGTTCCCGGGCGTCTGTATCGTGGTATCCCATGATCGCTTTTTCCTGGATCGAACCGTGGACAAGATTATGGCTTTTGAGGGCGACGGTCAGATTCGTGTCCATGTCGGCTCTTACAGCGAATATGCGGAATGGATGCAGCGTCACGGCGGTGAAGCTTCCGGGAGCAAGGCGGAGGCATCCATAGCCAAATCTGCTTCGGGGAGCAGCGATGGCACGGACAGTGATTCAGCTAAAGAAGCGCCGCGTGAGCGCTTGAAATTCAGTTACAAAGAACAACGGGAGTTTGATCAGATTGACGGGCTCATCGAGGATACCGAGAGCAAGCTCGCTTCGATTCAATCCGAGATGGAGACCGCCGGCAGCGACGCAGCCAGGCTTCAGGAGCTGATGAAGGCTCAGGAGGAAACGGAACGTGAGCTGGAGCATCTGATGGAACGCTGGACCTATCTGAACGAGCTCGCGGAGAAGATTGAACAGAGCAAGAAATCGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03219.1", "sequence": "MNILTVEQVTKSYGDKILFQDASFGMEDQDKIGIIGVNGTGKSTFLRVIAGLEPPDSGKISMGNRIRVRYLAQNPEFDPDKTVLQQVFEGDLPEMKAVREYTETMELLELHPSHEELQQKLLKLNQTLETLQAWQLESDAKTILSKLGIRNYEAKMGTLSGGQRKRVALAAALIQPSDLLILDEPTNHIDNESVAWLEQYLQKRRGALLMITHDRYFLDRVANVMLELDHGRLFRYEANYSRFLELKAEREEREAASEQKRQNLLRSELAWIRRGAKARTTKQKARIERFEKLKDQEMVHSSGELDVSVASTRLGRKILEIEGLRMKIDDKTLIQDLSYIAVPEDRIGIVGPNGSGKSTLLNLIAGRIQPGGGEVVLGPTVKLGYFTQEHQEMDGSQRVIEYIKDEAEVVRTADGSAITAAQMLERFLFPPALQWTPIAKLSGGEKRRLYLLRVLMSAPNVLLLDEPTNDLDIQTLSVLEQYLDEFPGVCIVVSHDRFFLDRTVDKIMAFEGDGQIRVHVGSYSEYAEWMQRHGGEASGSKAEASIAKSASGSSDGTDSDSAKEAPRERLKFSYKEQREFDQIDGLIEDTESKLASIQSEMETAGSDAARLQELMKAQEETERELEHLMERWTYLNELAEKIEQSKKS"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "TaeA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40868", "model_name": "TaeA", "model_type_id": "40292"}, "2529": {"model_id": "2529", "ARO_accession": "3003994", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "cpaA is a capreomycin acetyltransferase protein found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus in Lechuguilla Cave, NM, USA. Confers resistance to capreomycin, an aminoglycoside antibiotic. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3865": {"dna_sequence": {"fmax": "486", "fmin": "0", "accession": "KX531054.1", "strand": "+", "sequence": "ATGCCTCTTCGTATCACGGCCATGACCGAAACGTATGCCGATCAAATTATGCAATGGAGCTATGAACCTCCCTATGATTTCTACAACAGCGAACCGGATGAGGAGTTTCGGAAAGAACTTCTGGAGTGCTCGTATTACGCCATACTGGACAAGGAAGGGCAGCTCTTCGGCTTTTGCTGTACAGGCTCATCAGCCCAAATTCCGATCGCAATCCCGTTAGGTGCATATGACGAGGATCTGCTGGATTTCGGACTTGGGATGAAACCGGAATCGACCGGACAATGCCGGGGAAAAGAGTTTCTCTCGTTCGTGCTGGCATCCATCGCTGAATTTCACAAGCGCCAATCGTTTCGGCTGACCGTTGCCAAATTCAATGAACGAGCCATTCGCTTGTATACCCAGCTGGGCTTCTCGGAAGTTGCAACGTTTGATTATGGCGGCACTACGTTCATAACGATGATCAAGAAGCCGGGCTCCGGATTGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03224.1", "sequence": "MPLRITAMTETYADQIMQWSYEPPYDFYNSEPDEEFRKELLECSYYAILDKEGQLFGFCCTGSSAQIPIAIPLGAYDEDLLDFGLGMKPESTGQCRGKEFLSFVLASIAEFHKRQSFRLTVAKFNERAIRLYTQLGFSEVATFDYGGTTFITMIKKPGSGL"}}}}, "ARO_category": {"36243": {"category_aro_name": "aminoglycoside resistance protein", "category_aro_cvterm_id": "36243", "category_aro_accession": "3000104", "category_aro_description": "Enzymes or other proteins shown clinically to confer resistance to aminoglycoside antibiotics."}}, "ARO_name": "cpaA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40876", "model_name": "cpaA", "model_type_id": "40292"}, "2528": {"model_id": "2528", "ARO_accession": "3003992", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "rphB is a rifampin phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to rifamycin antibiotics, specifically rifampin, through rifampin inactivation. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3864": {"dna_sequence": {"fmax": "2655", "fmin": "0", "accession": "KX531052.1", "strand": "+", "sequence": "ATGCGTTCGTTGGTTCTCGATTTTCAGGAAATGGACAAAAAGCAGCTTGGGCTCGTTGGTGGAAAAGGGCTCCATTTAGGGGAATTATCAAAAATTGAGGGAATACGAGTTCCCGAAGGATTTTGCGTGACAACCATAGGATATCAAAGAGCCATCGAACAAAACGAAACGTATCAAGCTATGCTCAATCGACTAACCATGCTATCAGCAGAGGATCGAGATCAAATGGTTGAAATCAGCAGGAAGATCAGACAAACCATTATGGAGGTAGAAATTCCATCCGATGTAGTGACAGCAGTAACTCGCTATCTCTCCCGGTTTGGCGAGGAACAGGCTTATGCCGTACGATCCAGTGCAACTGCTGAAGATTTACCGCATGCCTCTTTTGCGGGTCAACAAGACACCTATCTAAACATCATCGGCGTCGATGCCATCTTGCAGCATATCAGCAAATGCTGGGCTTCCTTGTTTACAGATCGCGCGGTGATCTATCGCATGCAAAATGGATTTGACCATCGTCAAGTTTATTTATCCGTAGTCGTTCAAAGGATGGTTTTCCCCGAGGCTTCAGGGATATTATTCACCGCTGATCCGATGACTTCTAATCGAAAGCTGCTATCCATCGATGCCGGTTTCGGACTTGGAGAAGCACTGGTCTCTGGCTTGGTATCTGCCGATGGTTACAAAGTACGGGAAGGAGAAATCATCGAGAAGCGGATAGCAGCCAAAACATTGGCGATCTACGGACGAAAAGAAGGCGGAACAGAAACAAAGCAAATCGATCCCGATCAGCAAAAGTCACAAACACTTACGGATGAGCAAATTTTACAACTGGCACGCATCGGGAGACAGATTGAGGCTCATTTTGGCCAACCCCAAGATATCGAGTGGTGTTTGGCCCAGGATACCTTTTATATTGTCCAGAGTCGGCCAATCACGACGCTATACCCGATACCTGAAGCGAATGATCAAGAAAATCACGTATACGTATCTGTCGGTCATCAACAAATGATGACGGATCCCATGAAACCGCTGGGATTGTCTTTTTTCCTGCTAACGACTCCTGCACCCATGCGTACAGCTGGCGGAAGGTTGTTTGTTGATACTACGGCTATGCTGGCTTCACCGGTTAGCAGAGAAAATGTATTAAATACCCTGGGACAATCCGATCCACTCATCAAAGACGCTCTTATGACCATCTTAGAGCGAGGAGATTTTATAAAATCGCTACCCATCGCTGAAAATGAACAGACTCCCGGAAAAAACAATATATCGTCTGCGGGTTATCAAACGCCAATCGACCACGATCCGACAATCGTTTCTGATTTAATGGAACGTACTCAATCATCGATCGAAGTGTTGAAACAAAACATCCAAACGAAATCCGGATCCGATTTATTTGATTTTATATTGGAAGATATCCAGGAACTGAAGAAGAATTTATTTGACCCACAAAGCTCGGCTGTCATCATGGCTGCAATGAATGCTTCAACCTGGATCAACGAAAAAATGAATGAATGGTTAGGCGAAAAAAACGCAGCCGACACGCTTTCTCAATCCGTACCGGGCAATGTTACTTCGGAAATGGGTCTGGCGCTGCTGGATGTTGCAGACGTCATTCGTCCTTATCCGGAAATCATTGATTATTTGGAGCAAGCAAAAGATGATCACTTTTTGGATAAGCTGCTTACATTTGATGGCGGGCAGCAAGCTCAAGACGCGATCCTAGATTTTCTTGACAAATATGGCATGCGATGTGCTGGAGAAATCGATTTAACAAGAACTCGTTGGAGTGAAAAACCAATTGCGCTTGTTCCGTTGATTCTGGGTAACATCAAAAACTTCGAGCCTAATGCCAGCCATCGGAAATTCGAGCAAGGGCGGCAGGAAGCTTTGAAAAAAGAACAAGAGCTATTAGATCGATTGAAACAATTGCCGGACGGTGAAGGAAAAGCCCAAGAAACCAAACGAATGATTGACCTCATTCGGAATTTCATGGGTTATCGGGAATACCCGAAATACGGTATGGTGAATCGTTACTTTATTTATAAGCAGGCTTTACTGAAAGAGGCTGAACGACTCGTACAAGCGGGCGTTATTCATCATAAGGAAGATATATATTATCTCACTTTTGAAGAGCTTGACGAGGTCGTACGCACAAATAAACTGGATAACCCGGGTTCCATGGTCGAGCAGCAAGCAAAGCTTGCGATCAGACAGATGATCAGCAAACGAAAAGAGGAGTACAACGTATTTGAAAAACTAACTCCTCCGCGCGTGATCACGTCGGATGGTGAAATCATCGCAGGGGAGTACAAACGAGAAAATATCCCAGCCGAAGCTATTGTCGGCCTGCCTGTTTCTTCCGGAACGGTCGAAGGACGAGCGCGTGTCATCTTAAACATGAAAGACGCCGATCTCGAGGAAGGAGATATATTAGTCACCGCTTTTACCGACCCTAGCTGGACGCCTCTGTTTGTATCCATTAAGGGCTTGGTCACCGAAGTGGGCGGACTGATGACCCATGGAGCCGTTATCGCGCGTGAATATGGCTTACCGGCCGTTGTCGGCGTTGAGAATGCTACCAAACGGATAAAGGACGGGCAGCGCATTCGCGTACATGGGTCCGAAGGCTATATTGAAATATTGTCATAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03222.1", "sequence": "MRSLVLDFQEMDKKQLGLVGGKGLHLGELSKIEGIRVPEGFCVTTIGYQRAIEQNETYQAMLNRLTMLSAEDRDQMVEISRKIRQTIMEVEIPSDVVTAVTRYLSRFGEEQAYAVRSSATAEDLPHASFAGQQDTYLNIIGVDAILQHISKCWASLFTDRAVIYRMQNGFDHRQVYLSVVVQRMVFPEASGILFTADPMTSNRKLLSIDAGFGLGEALVSGLVSADGYKVREGEIIEKRIAAKTLAIYGRKEGGTETKQIDPDQQKSQTLTDEQILQLARIGRQIEAHFGQPQDIEWCLAQDTFYIVQSRPITTLYPIPEANDQENHVYVSVGHQQMMTDPMKPLGLSFFLLTTPAPMRTAGGRLFVDTTAMLASPVSRENVLNTLGQSDPLIKDALMTILERGDFIKSLPIAENEQTPGKNNISSAGYQTPIDHDPTIVSDLMERTQSSIEVLKQNIQTKSGSDLFDFILEDIQELKKNLFDPQSSAVIMAAMNASTWINEKMNEWLGEKNAADTLSQSVPGNVTSEMGLALLDVADVIRPYPEIIDYLEQAKDDHFLDKLLTFDGGQQAQDAILDFLDKYGMRCAGEIDLTRTRWSEKPIALVPLILGNIKNFEPNASHRKFEQGRQEALKKEQELLDRLKQLPDGEGKAQETKRMIDLIRNFMGYREYPKYGMVNRYFIYKQALLKEAERLVQAGVIHHKEDIYYLTFEELDEVVRTNKLDNPGSMVEQQAKLAIRQMISKRKEEYNVFEKLTPPRVITSDGEIIAGEYKRENIPAEAIVGLPVSSGTVEGRARVILNMKDADLEEGDILVTAFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENATKRIKDGQRIRVHGSEGYIEILS"}}}}, "ARO_category": {"36522": {"category_aro_name": "rifamycin resistance protein", "category_aro_cvterm_id": "36522", "category_aro_accession": "3000383", "category_aro_description": "Enzymes, other proteins, or their products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}}, "ARO_name": "rphB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40874", "model_name": "rphB", "model_type_id": "40292"}, "2518": {"model_id": "2518", "ARO_accession": "3003981", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Tetracycline resistant TetB(48) efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3854": {"dna_sequence": {"fmax": "816", "fmin": "0", "accession": "KX531045.1", "strand": "+", "sequence": "ATGAGCAGCTCCATGATTCAGCCTGGGACGGAACGTCAGCTTAAGAACCGCACGAGTTTGGGTCAGACGGTCCGAAATTCGTTGACGATGGCTTACCGCGGGCTGCTGAAGCTCCGGCGCACGCCCGAGCAGTTGTTTGACGTCACGTTTCAGCCCATTATTTTTACGCTGATGTTCACCTATATTTTTGGGGGCGCCATCTCGGGTGACGTGGCGAGTTATTTGCCCGTCATCATTCCCGGCATCCTCGTCCAGACCGTGATTACGACCTCCGTCGTCACAGGCGTTCAGCTGCGCGAGGATATGGATAAAGGCGTATTCGACCGATTCAAATCGCTGCCGATTGCACGCATCGCACCGCTGGCGGGTGCCCTGCTGGCAGACACGATTCGGTATACCATTGCGACAGTGCTTACCTTTACGATGGGATATATTATGGGGTATCGGCCCGAGGGCGGCTTGGGTTATGTTGCTCTTGCGGGGTTGGTCGTCATTTTGTGCTCATGGGCCATTAGCTGGATTTTTGCTTTCTGCGGCGTGATTGCAAGATCTGCCTCCGGCGTGCAGGGGATATCGATGATCGTGCTGTTTCCGCTCACGTTTCTCTCCAACGCGTTCGTGCCGGTGGATACGATGCCGGGCTGGCTGCAGTGGTTCGTCAATATGAATCCGATCTCGCATCTTGTGACAGCCGTTCGGGATCTCACCAACGCTGGCACCGTGGGCTGGGATCTCACGATATCCTTGGTTGGCGCCGCGGTTATCGTGGCGATCTTTGCTCCCATTACGGTTCGTGCGTACATGCGCCGCACTTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03215.1", "sequence": "MSSSMIQPGTERQLKNRTSLGQTVRNSLTMAYRGLLKLRRTPEQLFDVTFQPIIFTLMFTYIFGGAISGDVASYLPVIIPGILVQTVITTSVVTGVQLREDMDKGVFDRFKSLPIARIAPLAGALLADTIRYTIATVLTFTMGYIMGYRPEGGLGYVALAGLVVILCSWAISWIFAFCGVIARSASGVQGISMIVLFPLTFLSNAFVPVDTMPGWLQWFVNMNPISHLVTAVRDLTNAGTVGWDLTISLVGAAVIVAIFAPITVRAYMRRT"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "TetB(48)", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40863", "model_name": "TetB(48)", "model_type_id": "40292"}, "2519": {"model_id": "2519", "ARO_accession": "3003982", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "Lincosamide (Clindamycin) resistant (putative) ribosomal methyltransferase related to the RlmK 23S rRNA methyltransferase COG family. Detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus found in Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3855": {"dna_sequence": {"fmax": "864", "fmin": "0", "accession": "KX531046.1", "strand": "+", "sequence": "ATGTATGTAGCTCAGGATTGGCAAGATTACGAGGTCATCGATACCGGAGGCGGAGAAAAGCTGGAACGCTGGGGCGACGTGATTCTCAGACGTCCGGATCCGCAGATCATATGGCCGATTGAACGTGAAGATGGACAGTGGCGCAGTGTGCACGGACACTATCATCGCAGCTCGTCGGGCGGCGGACAATGGGACATGAAAAAGCAGCTTCCGGACCGGTGGACCATCTCATACGACCAATTGAAATTTCATATTCGACCAACCAATTTTAAACATACCGGTTTGTTTCCGGAGCAGGCAGCCAACTGGCGCTGGATGATGGATAAGATCGCTTCTGCCGGACGTCCGGTCAGCGTGCTGAACCTGTTCGCCTATACCGGCGGAGCAACCGTGGCGGCCGCTTCGGCCGGAGCTCAGGTTGTTCATGTGGATGCTGCGAAGGGAATGGTTCAATGGGCCAAGGAAAACGCGGCATTGTCCGGACTTGCCGACCGTCCTATCCGTTATATCACGGATGATGTGTTTAAATTCGTACAACGGGAGCAGCGTCGGGGGAACAAATACGATGCGATCATTATGGACCCTCCATCTTATGGCCGCGGACCAAGTGGAGAAACGTGGAAGCTTGAGCAAAGCTTGTATCCCTTCCTCGAAAGCTGCATGAGCATCGTATCGGATAATCCGCTGTTCATGCTGATTAACTCCTATACAACCGGGATCTCCCCTACCGTTCTGAATAACATGCTGACCATGACCATGAAGCCGAAATACGGCGGTACCATCAGTGCGGGAGAGATCGGATTGCCGATTACCCGCTCCGGCATGAACCTGCCGTGCGGCATCCTAGGTCGATGGGAGTCCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03216.1", "sequence": "MYVAQDWQDYEVIDTGGGEKLERWGDVILRRPDPQIIWPIEREDGQWRSVHGHYHRSSSGGGQWDMKKQLPDRWTISYDQLKFHIRPTNFKHTGLFPEQAANWRWMMDKIASAGRPVSVLNLFAYTGGATVAAASAGAQVVHVDAAKGMVQWAKENAALSGLADRPIRYITDDVFKFVQREQRRGNKYDAIIMDPPSYGRGPSGETWKLEQSLYPFLESCMSIVSDNPLFMLINSYTTGISPTVLNNMLTMTMKPKYGGTISAGEIGLPITRSGMNLPCGILGRWES"}}}}, "ARO_category": {"36658": {"category_aro_name": "antibiotic target modifying enzyme", "category_aro_cvterm_id": "36658", "category_aro_accession": "3000519", "category_aro_description": "Enzymes that confer resistance by modifying antibiotic targets."}}, "ARO_name": "LlmA 23S ribosomal RNA methyltransferase", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40864", "model_name": "LlmA 23S ribosomal RNA methyltransferase", "model_type_id": "40292"}, "2551": {"model_id": "2551", "ARO_accession": "3003722", "ARO_name": "glycopeptide resistance gene cluster VanI", "ARO_description": "This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX", "ARO_category": {"35929": {"category_aro_name": "antibiotic resistance gene cluster, cassette, or operon", "category_aro_cvterm_id": "35929", "category_aro_accession": "0000010", "category_aro_description": "Clusters of antibiotic resistance genes. May be regulated by a shared promoter or repressor."}}, "model_param": {"40297": {"param_value": {"4683": "R:40383,R:40385,C:40377,A:40380,C:40384,C:40381"}, "param_type_id": "40297", "param_type": "gene order", "param_description": "A parameter to describe the relative order of genes detected by multiple detection models. The parameter is defined by a series of cvterm_id separated by commas."}}, "model_type": "gene cluster model", "model_description": "A meta-model to detect a defined gene cluster based on gene detection by other models.", "ARO_id": "40376", "model_name": "glycopeptide resistance gene cluster VanI", "model_type_id": "40298"}, "2550": {"model_id": "2550", "ARO_accession": "3003995", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "snp": {"param_type": "single resistance variant", "param_value": {"4650": "A384D"}, "clinical": {"4650": "A384D"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Amino acid substitutions in Clostridium difficile gyrase subunit A which when present confer functional resistance to fluoroquinolone antibiotics.", "model_sequences": {"sequence": {"3887": {"dna_sequence": {"fmax": "8492", "fmin": "6065", "accession": "NC_009089.1", "strand": "+", "sequence": "ATGGAAGAAAATAACAAAATACTCCCTATTGAAATAGCGGAAGAAATGAAAAAATCGTATATTGATTATTCAATGAGTGTTATAGCTGGACGTGCTCTTCCTGATGTTAGAGATGGTTTAAAGCCAGTTCATAGAAGAATATTATATTCAATGAGTGAGTTAAATTTAACTCCAGATAAACCATACAGGAAGTCAGCTCGTATTGTTGGGGACGTTTTAGGTAAGTACCATCCTCATGGAGATACTGCTGTTTATTATGCTATGGTAAGAATGGCACAAGATTTTTCAACTAGAGCACTTTTAGTAGATGGTCATGGTAACTTTGGTTCTGTTGATGGGGATTCACCAGCTGCTATGCGTTATACAGAAGCTAAAATGAGTAAATTATCATTAGAACTACTGAGAGATATTGAAAAGGAAACTGTAGACTTTAAACCAAACTTTGATGAGTCGTTAAAAGAGCCTTCAGTATTGCCAGCTAGATATCCTAATTTATTAGTAAATGGCTCAAATGGTATAGCTGTTGGTATGGCAACTTCAATACCTCCACATAATTTAGCAGAAGTAATTGATGCAACTGTATATTTGATAGATAATCCAGAGTGTAGTGTAGATGATTTAATAAAATTTGTTCAAGGACCAGATTTCCCTACAGCTGCAATTATAATGGGAAAAGAAAGTATAGCAGAAGCATACAGAACTGGAAGAGGAAAAGTTAAAGTTAGGTCTAGAGCTTTTATAGAAGAGCTACCAAAAGGAAAACAGCAAATAATAGTTACAGAAATACCTTATCAAGTAAATAAGGCTAAACTGGTTGAAAGAATAGCAGAGTTAGTTAAAGAAAAGAGAATAGAAGGTATATCAGACCTAAGAGACGAAAGTAATAGAAATGGTATGAGAATTGTTATAGAATTAAAGAGGGATGCTAATGCTAATATAGTATTAAATAATTTGTATAAACATTCTCAAATGGAAGATACTTTTAGTATAATAATGCTTGCACTTGTAGATGGTCAGCCAAGAGTTTTAAATCTTAAACAAATATTATATCATTATATTAAACATCAAGAAGATGTTGTTACAAGAAGAACTAAATTTGAACTAAATAAAGCTGAAGCAAGAGCACATATTTTAGAAGGATTAAAGATTGCTTTAGATAATATAGATGCTGTTATAAGCTTGATAAGAGCTTCAAAGACTGGGCAAGAAGCTAAGCTAGGTTTAATAGAAAAATTCAAATTAACTGAAATCCAAGCACAAGCTATATTAGATATGAGACTTCAAAGACTTACAGGTTTAGAAAGAGATAAGATAGAAGCTGAATATGAAGATTTAATCAAGAAGATAAATAGATTAAAAGAGATTTTAGCTGATGAAAGATTACTTTTAAATGTAATAAAGGATGAAATTACAATAATAAAAGAAAATTACTCTGATGAGAGAAGAACAGAAATAAGACATGCTGAAGGCGAAATAGATATGAGAGATCTTATAAGTGATGAAGAAATAGCAATAACTCTTACTCACTTTGGATATATAAAAAGGCTTCCATCTGATACTTATAAGAGTCAAAAAAGGGGTGGAAGAGGTATTTCAGCACTTACAACTAGAGAAGAAGATTTTGTAAGGCACTTGGTAACTACAACTACTCATAGTAGACTATTATTCTTTACAAATAAAGGTAGAGTATTTAAATTAAATGCATATGAAATACCAGAAGGTAAGAGACAGGCTAAAGGTACTGCTATAGTGAATTTACTTCAATTGTCAGCAGATGAGAAAATTGCTACTCTAATACCTATTGATGGTAATGATGAAAATGAATATTTATTACTTGCAACGAAAAAAGGTATTGTTAAAAAGACTAAGAGAGAAGAGTTCAAAAATATAAATAAATCTGGTCTTATTGCAATAGGTTTAAGAGATGATGATGAGCTTATTGGAGTAGAACTTACAGATGGAAAACAAGAAGTACTTTTAGTAACTAAAGAAGGTATGTCTATAAGATTTGATGAAAATGATATAAGATATATGGGTAGAACAGCAATGGGTGTAAAAGGTATAACTTTAAGTAAAGAAGATTTTGTTGTGTCTATGAACCTTTGTAGTAAAGGTACAGATGTGTTAGTTGTAAGTAAGAATGGTTTTGGAAAGAGAACAAATATAGAAGAGTATAGAAGTCAAATAAGAGCTGGTAAAGGAATTAAAACTTATAATATATCTGAAAAAACTGGTACAATTGTAGGTGCAGATATGGTCAACGAAGATGATGAGATAATGATTATAAATTCTGATGGAGTTCTTATTAGAATAAGAGTCAATGAAATATCACTGTTTGGAAGAGTTACAAGTGGTGTTAAATTAATGAAGACGAATGATGAAGTCAATGTAGTTTCGATTGCCAAAATAAATATTGAAGAAGAATAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Clostridium difficile 630", "NCBI_taxonomy_id": "272563", "NCBI_taxonomy_cvterm_id": "37603"}, "protein_sequence": {"GI": "YP_001086469.1", "sequence": "MEENNKILPIEIAEEMKKSYIDYSMSVIAGRALPDVRDGLKPVHRRILYSMSELNLTPDKPYRKSARIVGDVLGKYHPHGDTAVYYAMVRMAQDFSTRALLVDGHGNFGSVDGDSPAAMRYTEAKMSKLSLELLRDIEKETVDFKPNFDESLKEPSVLPARYPNLLVNGSNGIAVGMATSIPPHNLAEVIDATVYLIDNPECSVDDLIKFVQGPDFPTAAIIMGKESIAEAYRTGRGKVKVRSRAFIEELPKGKQQIIVTEIPYQVNKAKLVERIAELVKEKRIEGISDLRDESNRNGMRIVIELKRDANANIVLNNLYKHSQMEDTFSIIMLALVDGQPRVLNLKQILYHYIKHQEDVVTRRTKFELNKAEARAHILEGLKIALDNIDAVISLIRASKTGQEAKLGLIEKFKLTEIQAQAILDMRLQRLTGLERDKIEAEYEDLIKKINRLKEILADERLLLNVIKDEITIIKENYSDERRTEIRHAEGEIDMRDLISDEEIAITLTHFGYIKRLPSDTYKSQKRGGRGISALTTREEDFVRHLVTTTTHSRLLFFTNKGRVFKLNAYEIPEGKRQAKGTAIVNLLQLSADEKIATLIPIDGNDENEYLLLATKKGIVKKTKREEFKNINKSGLIAIGLRDDDELIGVELTDGKQEVLLVTKEGMSIRFDENDIRYMGRTAMGVKGITLSKEDFVVSMNLCSKGTDVLVVSKNGFGKRTNIEEYRSQIRAGKGIKTYNISEKTGTIVGADMVNEDDEIMIINSDGVLIRIRVNEISLFGRVTSGVKLMKTNDEVNVVSIAKINIEEE"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "36241": {"category_aro_name": "fluoroquinolone resistance protein", "category_aro_cvterm_id": "36241", "category_aro_accession": "3000102", "category_aro_description": "Enzymes, other proteins or their products shown clinically to confer resistance to fluoroquinolones."}}, "ARO_name": "Clostridium difficile gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "40901", "model_name": "Clostridium difficile gyrA conferring resistance to fluoroquinolones", "model_type_id": "40293"}, "2517": {"model_id": "2517", "ARO_accession": "3003980", "model_param": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "TetA(48) is a Tetracycline efflux pump described in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016.", "model_sequences": {"sequence": {"3853": {"dna_sequence": {"fmax": "1032", "fmin": "0", "accession": "KX531044.1", "strand": "+", "sequence": "ATGGAGCATGCATACAAAAAGAAAATAGAACCAAAACCTGGCGACTTGGCCGTTGAGGCTTACGGACTGATCAAAACATTCGGAGATAACCGCGCCGTGGATGGGGTGGATCTGAACGTACGTACCGGAACGATCTACGGTGTACTTGGCCCGAATGGGGCAGGCAAGACGACCACCATCCGAATGCTGGCGACCTTGCTAAGACCGGATGCGGGTTCGGCCCGAATCTTCGGACATGATGTGCAGGCGGAATCGCAGATTGTCCGTCAGTTGATCGGGGTAACCGGCCAATACGCGTCGGTGGACGAATCGCTCAGCGCTACGGAGAATCTGATTATATTCTCACGTTTGCTTGGTTTGGGGCGTAAGGAGGCAAGGCGCAAGGCGGAAGAGCTGCTCGAGGAATTCGGTTTGTCGGAAGCCGCGAAGCGGCCGCTAAAAAATTTCTCGGGCGGCATGCGGAGAAGGCTGGATCTGGCGGCAAGCCTGATTGCCCAGCCGCCGCTTATCTTCCTGGATGAACCGACGACGGGGCTGGATCCAAGGACGCGTTCCCAGATGTGGGATACGATCCGCCGATTGGTGAATACCGGTTCAACGGTATTGCTGACCACGCAGTATCTCGAGGAGGCCGACCAGCTGGCAGACCGCATCGCCGTTATCGATTACGGCCGGGTTGTGGCCGAGGGGACGGCCGATGAACTGAAGATGTCGGTGGGCACTTCCTCGCTGCATTTGACTGTCGAGGATTCGGTTGACATGGATCGCGCCTGCCATACCGTGGAACAAGTGTTAGGCGTCCATGCCAATGTATCGCCGGAAGCCGGAAAGATAACGGCGCCGATGGCTAATGCGGGTCTTGTTACAGACCTGCTGATCGAGCTGCGAACAGCAGGAATCGGCTTGTCCGAGATGAGCGTGCAGAAGCCGACCCTGGATGAGGTGTTCCTAACGATCACCGGCCACGGCGTGAAGGAAGACGCTGCCCAAGAGTCTTATGAATCCAATGATCGGGAGGTGGCACGGGTATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus sp. LC231", "NCBI_taxonomy_id": "1120679", "NCBI_taxonomy_cvterm_id": "40862"}, "protein_sequence": {"GI": "APB03214.1", "sequence": "MEHAYKKKIEPKPGDLAVEAYGLIKTFGDNRAVDGVDLNVRTGTIYGVLGPNGAGKTTTIRMLATLLRPDAGSARIFGHDVQAESQIVRQLIGVTGQYASVDESLSATENLIIFSRLLGLGRKEARRKAEELLEEFGLSEAAKRPLKNFSGGMRRRLDLAASLIAQPPLIFLDEPTTGLDPRTRSQMWDTIRRLVNTGSTVLLTTQYLEEADQLADRIAVIDYGRVVAEGTADELKMSVGTSSLHLTVEDSVDMDRACHTVEQVLGVHANVSPEAGKITAPMANAGLVTDLLIELRTAGIGLSEMSVQKPTLDEVFLTITGHGVKEDAAQESYESNDREVARV"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "tetA(48)", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "40861", "model_name": "tetA(48)", "model_type_id": "40292"}}}