{"$update": {"344": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "346": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "347": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "340": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "341": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "343": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "348": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "349": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "2317": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}}}, "2310": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "determinant of elfamycin resistance"}}}}}}, "298": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "299": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "296": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "297": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "294": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "295": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "292": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "293": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "290": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "291": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "270": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "271": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "272": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "273": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "274": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "275": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "277": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "278": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "279": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "581": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1132": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2260": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "2261": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "2267": {"$update": {"ARO_category": {"$update": {"40420": {"$update": {"category_aro_name": "determinant of nitrofuratoin resistance"}}}}, "model_name": "Escherichia coli nfsA mutations conferring resistance to nitrofurantoin", "model_param": {"$insert": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}}, "2445": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "108": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "109": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "102": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "103": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "100": {"$update": {"ARO_category": {"$insert": {"41151": {"category_aro_name": "determinant of ethionamide resistance", "category_aro_cvterm_id": "41151", "category_aro_accession": "3004071", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to the second-line anti-tubercular agent, ethionamide."}}}, "model_name": "Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide", "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "101": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "106": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "107": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "104": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "105": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2046": {"$update": {"model_name": "tet(33)"}}, "2047": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2044": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2045": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2042": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2043": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2040": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2041": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2048": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2049": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1213": {"$update": {"model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}, "model_type_id": "41091"}}, "99": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "98": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "90": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "93": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "92": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "95": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "94": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "97": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "96": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1623": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1622": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1621": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1620": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1627": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1994": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}, "model_name": "gimA"}}, "1625": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1996": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1999": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1998": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "_comment": {"access": "public", "description": "This is a comment to describe the whole JSON structure for CARD"}, "1628": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "559": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "555": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "554": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "557": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "556": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "551": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "550": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "553": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "552": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1199": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1190": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1193": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1192": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1195": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1194": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1197": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1196": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1759": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1758": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1756": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1755": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1754": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1753": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1751": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1750": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1177": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1176": {"$update": {"ARO_category": {"$update": {"40016": {"$update": {"category_aro_name": "determinant of isoniazid resistance"}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "1175": {"$update": {"ARO_category": {"$update": {"39620": {"$update": {"category_aro_name": "determinant of resistance to lipopeptide antibiotics"}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "1174": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1173": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1172": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1171": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "1170": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1179": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1178": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "511": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "510": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1005": {"$update": {"ARO_name": "Escherichia coli soxR with mutation conferring antibiotic resistance", "model_param": {"$update": {"40334": {"$update": {"param_value": {"$insert": {"7540": "nt1130-2"}}, "param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}, "$insert": {"40494": {"param_value": {"7541": "L148fs"}, "param_type_id": "40494", "param_type": "frameshift", "param_description": "Insertion or deletion causing a frameshift mutation. These may contain data on the new STOP codon location if reported in the literature. For example, the notation for a frameshift after K136 creating a new STOP codon at P167 is: K136fs;P167STOP. If new STOP is unknown, K136fs is sufficient."}}}, "model_name": "Escherichia coli soxR with mutation conferring antibiotic resistance"}}, "1285": {"$update": {"ARO_category": {"$update": {"40980": {"$update": {"category_aro_name": "determinant of resistance to nucleoside antibiotics"}}}}, "model_name": "SAT-1"}}, "1284": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1287": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1286": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1281": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1280": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1283": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1282": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1003": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1289": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1288": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "514": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1579": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1578": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "689": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "688": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "685": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "684": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "687": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "686": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "681": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "680": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "683": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "682": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1227": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1349": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "621": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "873": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1224": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "627": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "1222": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "1221": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "624": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}, "model_name": "Mycobacterium leprae rpoB mutations conferring resistance to rifampicin"}}, "407": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1370": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "405": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1372": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1375": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1374": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1377": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "400": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1379": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1378": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1342": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}, "model_name": "plasmid-encoded cat (pp-cat)"}}, "409": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "408": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "454": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "455": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1347": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1245": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "379": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "378": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "371": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "370": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "373": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2038": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "374": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "376": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "393": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "392": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "391": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "390": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "397": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "396": {"$update": {"ARO_category": {"$update": {"36547": {"$update": {"category_aro_name": "determinant of sulfonamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to sulfonamide antibiotics."}}}}}}, "395": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "394": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "399": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "398": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1247": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2306": {"$update": {"model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "model_name": "Escherichia coli acrR with mutation conferring multidrug antibiotic resistance", "ARO_name": "Escherichia coli acrR with mutation conferring multidrug antibiotic resistance", "model_type_id": "41091"}}, "244": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "247": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "246": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "241": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "240": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "243": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "242": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "249": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}, "model_name": "basS"}}, "248": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2275": {"$update": {"ARO_category": {"$insert": {"36454": {"category_aro_name": "determinant of macrolide resistance", "category_aro_cvterm_id": "36454", "category_aro_accession": "3000315", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}, "2274": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "2277": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "2279": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "2278": {"$update": {"ARO_category": {"$update": {"36668": {"$update": {"category_aro_name": "determinant of mupirocin resistance"}}}}}}, "2198": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "179": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "178": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "177": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "176": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "175": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "174": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "173": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "172": {"$update": {"model_name": "OprN", "ARO_name": "OprN"}}, "171": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "170": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2051": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "2050": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2053": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "2052": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2055": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2057": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1503": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2059": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1500": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1501": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1504": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1977": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "659": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1973": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1972": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1971": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1970": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1968": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1969": {"$update": {"model_name": "tet(35)"}}, "1618": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1619": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1616": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1617": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1614": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1615": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1612": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1613": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1610": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1611": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1768": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1769": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1762": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1763": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1760": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1761": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1766": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1767": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1764": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1765": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1142": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1143": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1140": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1141": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1146": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1147": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1144": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1145": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1148": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1149": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "690": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "692": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "693": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1544": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "691": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "696": {"$update": {"ARO_category": {"$update": {"36406": {"$update": {"category_aro_name": "determinant of linezolid resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to linezolid antibiotics."}}, "36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "697": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "694": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1541": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "698": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "699": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1548": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1549": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "543": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "541": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "546": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "547": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "544": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "545": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "548": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "549": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1782": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1783": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1784": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1785": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1786": {"$update": {"ARO_name": "MexY"}}, "1787": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "414": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "415": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "416": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "417": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "410": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "411": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "412": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "413": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1384": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1386": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1387": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1380": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "419": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1382": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1383": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "368": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "369": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "366": {"$update": {"ARO_category": {"$update": {"40134": {"$update": {"category_aro_name": "determinant of resistance to polyamine antibiotics"}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "367": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "364": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "365": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "362": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "363": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "360": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "361": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "380": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "381": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "382": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "383": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}, "model_name": "Pseudomonas mutant PhoQ conferring resistance to colistin"}}, "384": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "385": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "386": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "388": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "389": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "2191": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "258": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2196": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "252": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "253": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "251": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "256": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "257": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "254": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "255": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}, "model_name": "determinant of bleomycin resistance", "ARO_name": "determinant of bleomycin resistance"}}, "2200": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2201": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2202": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2203": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}}}, "2204": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2205": {"$update": {"ARO_name": "MexJ"}}, "2206": {"$update": {"ARO_name": "MexK"}}, "2207": {"$update": {"ARO_name": "MexV"}}, "2208": {"$update": {"ARO_name": "MexW"}}, "1849": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "1848": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "168": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "169": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "164": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "165": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "166": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "167": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "160": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "161": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "162": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "163": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2518": {"$update": {"model_name": "tetB(48)"}}, "1980": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1841": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1840": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "678": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "679": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1814": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1815": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1816": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1810": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1811": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1812": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1813": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1818": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1819": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "670": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "671": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1609": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1608": {"$update": {"ARO_name": "MexT", "ARO_description": "MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN, OprD, and MexS.", "model_sequences": {"$update": {"sequence": {"4032": {"dna_sequence": {"fmax": "2807469", "fmin": "2807468", "accession": "NC_002516.2", "strand": "+", "sequence": "A"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_251182.1", "sequence": "MPVSDPMPLRHLARPRPVSHARLDGEPPRLQPLAPGNEERHEPKRPAPRRSEPADRVRDPDARTQRDPRRRETVPRPAGQPAISAALSRLRTLFDDPLFVRTGRSMEPTARAQEIFAHLSPALDSISTAMSRASEFDPATSTAVFRIGLSDDVEFGLLPPLLRRLRAEAPGFVLVVRRANYLLMPNLLASGEISVGVSYTDELPANAKRKTVRRSKPKILRADSAPGQLTLDDYCARPHALVSFAGDLSGFVDEELEKFGRKRKVVLAVPQFNGLGTLLAGTDIIATVPDYAAQALIAAGGLRAEDPPFETRAFELSMAWRGAQDNDPAERWLRSRISMFIGDPDSL"}}}}}, "model_param": {"$insert": {"snp": {"param_type": "single resistance variant", "param_value": {"7571": "Y138D", "7570": "G258D"}, "clinical": {"7571": "Y138D", "7570": "G258D"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}, "model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "model_name": "MexT", "model_type_id": "41091"}}, "1979": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "1978": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1601": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1600": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}, "model_name": "Pseudomonas mutant PhoP conferring resistance to colistin"}}, "1603": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1602": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1605": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1604": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1607": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}, "model_name": "Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin"}}, "1606": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "809": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "808": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "803": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "802": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "801": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "800": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "807": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "806": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "805": {"$update": {"model_name": "MexC", "ARO_name": "MexC"}}, "804": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "1775": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1774": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1777": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1776": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1771": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1770": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1773": {"$update": {"model_name": "tet(43)"}}, "1772": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1779": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1778": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1159": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1158": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1155": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1154": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1157": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1156": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1151": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1150": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1153": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1152": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1555": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1551": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1553": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "1552": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "59": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "58": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1557": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1556": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "55": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "54": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "57": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "56": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "51": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "50": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "53": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "52": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "537": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "536": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "535": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "534": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "533": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "532": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "531": {"$update": {"ARO_category": {"$update": {"40980": {"$update": {"category_aro_name": "determinant of resistance to nucleoside antibiotics"}}}}, "model_name": "SAT-3"}}, "530": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "539": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1558": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "428": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1399": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1398": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "421": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "420": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "423": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "422": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "425": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1392": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "427": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "426": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "229": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "227": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "226": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "225": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "224": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "223": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "222": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "221": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "220": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2215": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}, "model_name": "Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolone"}}, "2219": {"$update": {"ARO_name": "MexL"}}, "151": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "150": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "155": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "157": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "156": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "158": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "2436": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}, "$insert": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}}, "1807": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1806": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1805": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1804": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1803": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1802": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1801": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1800": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1809": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1808": {"$update": {"model_name": "tet(A)"}}, "1948": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1949": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1525": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1942": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}, "model_name": "BJP-1 beta-lactamase"}}, "1943": {"$update": {"ARO_category": {"$update": {"40016": {"$update": {"category_aro_name": "determinant of isoniazid resistance"}}}}}}, "1940": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1941": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1946": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1947": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1944": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1945": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "818": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "819": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1527": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "810": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "811": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "812": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "813": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "814": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "815": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "816": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "817": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1522": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1990": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1523": {"$update": {"model_name": "MexD", "ARO_name": "MexD"}}, "1993": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1490": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1491": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "1492": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1493": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1494": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1495": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1496": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1497": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1498": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1499": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1395": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}, "36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "1700": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1701": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1702": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1703": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "1704": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1705": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1706": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1707": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1708": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "1709": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "424": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1391": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1629": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1128": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1129": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1120": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1121": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1122": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1123": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1124": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1125": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1126": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1127": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "524": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "525": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "526": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "527": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1018": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "521": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "523": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1014": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1016": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1017": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "528": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "529": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1012": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1013": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1234": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1235": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1236": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1237": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "1230": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1233": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "1238": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1239": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "_version": "1.1.6", "438": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "439": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "436": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "437": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "434": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "435": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "433": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "430": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "431": {"$update": {"model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "model_name": "Escherichia coli marR mutant conferring antibiotic resistance", "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"7640": "S3N"}}, "clinical": {"$insert": {"7640": "S3N"}}}}}}, "model_type_id": "41091"}}, "1967": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1961": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "238": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "239": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "234": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "235": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "236": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "237": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "230": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "231": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "232": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "233": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2462": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2228": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2229": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2227": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2224": {"$update": {"model_name": "Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem"}}, "2222": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2223": {"$update": {"ARO_description": "MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa.", "model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "ARO_name": "MexZ", "model_type_id": "41091"}}, "2221": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "146": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "147": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "144": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "145": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "142": {"$update": {"model_name": "tet(E)"}}, "143": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "140": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "141": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "148": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "149": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2088": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2083": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2080": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2086": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "2087": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2084": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2085": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1832": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1833": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1830": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1831": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1836": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1837": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1834": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1835": {"$update": {"model_name": "tet(38)"}}, "1838": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1839": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2154": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2155": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "2156": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2157": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2402": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2403": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2152": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2401": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "933": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "932": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "931": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "937": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "936": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "935": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2409": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1955": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1954": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1957": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1956": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1951": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1950": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "1953": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1952": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1959": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1958": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "829": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "828": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "825": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "824": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "827": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "826": {"$update": {"ARO_name": "TolC"}}, "821": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "823": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "822": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1536": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1483": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1482": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1481": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1480": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1487": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1486": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1485": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1484": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1489": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1488": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "797": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2411": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "795": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "794": {"$update": {"ARO_category": {"$update": {"39620": {"$update": {"category_aro_name": "determinant of resistance to lipopeptide antibiotics"}}}}}}, "793": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "792": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "791": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "929": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1718": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}, "model_name": "DIM-1 beta-lactamase"}}, "799": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1270": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2412": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1271": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1272": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1139": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1138": {"$update": {"model_name": "tet(D)"}}, "1133": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "616": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1131": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1130": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1137": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1136": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1135": {"$update": {"ARO_category": {"$update": {"36616": {"$update": {"category_aro_name": "determinant of aminocoumarin resistance"}}}}}}, "1134": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "1276": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1277": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "519": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "518": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "926": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1009": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1008": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1007": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1006": {"$update": {"model_name": "tet(V)"}}, "513": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "927": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "515": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "1002": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1001": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}, "39620": {"$update": {"category_aro_name": "determinant of resistance to lipopeptide antibiotics"}}}}}}, "1000": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "623": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "622": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1225": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "620": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1223": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "626": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "625": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1220": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "629": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "628": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1229": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1228": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1535": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1561": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "11": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "10": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "13": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "12": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "15": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "14": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "17": {"$update": {"model_name": "tet(45)"}}, "16": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "19": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "18": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1534": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "201": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "200": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "203": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "202": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "205": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "204": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "207": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "206": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "209": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "208": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1573": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1572": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1571": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1570": {"$update": {"ARO_name": "OprA"}}, "2231": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2230": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2233": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2232": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2235": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2234": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1576": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1575": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1574": {"$update": {"ARO_category": {"$update": {"40016": {"$update": {"category_aro_name": "determinant of isoniazid resistance"}}, "40348": {"$update": {"category_aro_name": "determinant of triclosan resistance"}}}}}}, "2097": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2096": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2091": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2090": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2093": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2092": {"$update": {"ARO_name": "Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance", "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}, "$insert": {"40494": {"param_value": {"7538": "A47fs"}, "param_type_id": "40494", "param_type": "frameshift", "param_description": "Insertion or deletion causing a frameshift mutation. These may contain data on the new STOP codon location if reported in the literature. For example, the notation for a frameshift after K136 creating a new STOP codon at P167 is: K136fs;P167STOP. If new STOP is unknown, K136fs is sufficient."}}}, "model_name": "Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance"}}, "2099": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2098": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "2525": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2524": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2527": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "2526": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "2521": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "2520": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "2523": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "2522": {"$update": {"model_param": {"$update": {"blastp_evalue": {"$update": {"param_value": "1e-150"}}, "blastp_bit_score": {"$update": {"param_value": "1200"}}}}}}, "2529": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2528": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "1829": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1828": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1825": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1824": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "1827": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1821": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1820": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "1823": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1822": {"$update": {"ARO_category": {"$update": {"36616": {"$update": {"category_aro_name": "determinant of aminocoumarin resistance"}}}}}}, "2147": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "determinant of elfamycin resistance"}}}}}}, "2146": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2145": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "2144": {"$update": {"ARO_category": {"$update": {"40134": {"$update": {"category_aro_name": "determinant of resistance to polyamine antibiotics"}}}}}}, "2143": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2142": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "2141": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2140": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "920": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "921": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "922": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "923": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "924": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "925": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2149": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2148": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1920": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1921": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "1923": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1924": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1925": {"$update": {"model_name": "MexB", "ARO_name": "MexB"}}, "1926": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1927": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1928": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1929": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "832": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "833": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "830": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "831": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "836": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "837": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "834": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "835": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "838": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "839": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "3": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}, "model_name": "Escherichia coli ompF with mutation"}}, "1986": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1987": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1532": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "784": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "785": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "786": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "787": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "780": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "781": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "782": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1729": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1726": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1727": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1724": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1725": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "788": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "789": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1721": {"$update": {"ARO_category": {"$update": {"36547": {"$update": {"category_aro_name": "determinant of sulfonamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to sulfonamide antibiotics."}}}}, "model_name": "Mycobacterium leprae folP with mutation conferring resistance to dapsone"}}, "60": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "61": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "62": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "63": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "64": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "65": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "66": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "67": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "68": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "69": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1371": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1588": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1589": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "406": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1582": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1583": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1580": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1581": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1586": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1373": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1584": {"$update": {"model_name": "tet(41)"}}, "1585": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "404": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "509": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1032": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "403": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "504": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1031": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "502": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "503": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "500": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "402": {"$update": {"model_name": "tet(Y)"}}, "1212": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "631": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "632": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}, "model_name": "basR"}}, "1211": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1216": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "401": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "636": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "637": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "638": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "639": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1218": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1219": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1394": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "465": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1728": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "783": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1106": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1455": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1104": {"$update": {"model_sequences": {"$update": {"sequence": {"4015": {"dna_sequence": {"fmax": "484403", "fmin": "481253", "accession": "NC_000913.3", "strand": "-", "sequence": "TCAATGATGATCGACAGTATGGCTGTGCTCGATATCTTCATTCTTGCGGCTAAAGCGGCGGCGAACCACCACAAAGAATACCGGAACGAAGAAGATTGCCAGTACCGTTGCGGTCACCATCCCGCCCATTACACCGGTACCTACTGCGTTCTGCGCGCCGGAACCAGCACCAGTACTGATAACCAGCGGCATAACGCCGAGGATAAACGCCAGCGAGGTCATCAGGATCGGACGTAAACGCATCCGCACCGCATCAAGCGTCGCTTCAATCAGACCTTTACCTTCTTTATCCATCAAGTCTTTGGCGAATTCGACGATAAGGATCGCGTTCTTCGCCGACAACCCAATGGTTGTGAGCAGGCCTACCTGGAAGTAAACGTCATTGGTCAGGCCACGGAAGGTGGCAGCCAGCAACGCACCGATAACCCCCAGCGGAACGACCAGCATAACGGAGAACGGAATCGACCAGCTCTCGTACAGCGCCGCCAGACACAGGAACACGACAATCAACGAAATCGCGTACAGTGAAGGTGCCTGGTTGCCGGAGAGACGTTCCTGATAGGACATCCCCGTCCAGTCATAGCCAACACCGGTAGGCAGTTTGCTCGCCAGTTGTTCCATCAGCTCCATTGCTTCACCGGTACTTTTACCCGGTGCCGCCTGGCCTAAGATTTCCATGGATGGCAGGCCGTTGTAACGTTCCAGACGCGGCGAACCGTACTCCCAACGAGAAGAGGAGAACGCCGAGAATGGCACCATCTGACCATCAGCAGCACGAACATACCAGTCGCCGATATCATCCGGCAGCATACGGTATTTCGCTTCTGACATGACATAAACTTTCTTCACACGACCGCGGTCGATAAAGTCGTTCACATAGCTGCCGCCCCATGCAGCGCCCAGAGTGGTGTTAATGTCGTTGATAGAAACACCCAGCGCCTGCGCTTTTTCCTGGTCGATATCAATCTTAAACTGCGGGGTATCTTCCAGACCGTTTGGACGTACGCTGGTCAACATATCAGGGTGCTTCGCTGCTTCTGCAAGCAACTGGTTACGCGCCTGAGTCAGTTTTTCGTGACCAAGGCCAGCCTGGTCAATCAGCTCAAAGTCAAAGCCGGTTGCAGTACCCAGTTCCACGATTGCGGGCAGGTTAAAGGCGAAAACCATCGCATCTTTGATTTGCGAGAAAGCGCGTGTTGCACGCATGGTAATCGCTTCAACTTTGTTTTCTTCGCCCGGACGATCGGCCCAGTCCTTCAAGGAAACGAACGCAATACCGGTATTCTGACCACGTCCCGCAAAGCCGAAGCCGTTAACGGCGAACACCGACTCAACGTTGTTCTTTTCTTTGGTCAGATAGTAATGCGTTACCTCATTGAGCACTTTCTGTGTACGTTCCTGCGTTGCACCTGCTGGCAGCTGAACCATGGTCATAAACACGCCCTGGTCCTCATCTGGCAAGAAGGAGCTTGGCAGACGCACGAACAGATAGGCCATGCCGACCACGATGATCAGATACAGCACCAGGTAACGCCCCGTACTGCGCAGAATACCGCCTACGCTGTCGGTGTAGTGGTGCGTGCTCTTCTCGAACATGCGGTTAAACCAGCCGAAGAAGCCTTTTTTACCTTCCCCGTGATCGCCTTTGGCAATCGGTTTCAGCATGGTGGCACAAAGAGCTGGAGTCAGGATCAACGCCACCAGTACCGACAGCGCCATTGCTGAAACAATGGTAATAGAGAACTGACGATAGATAGCACCAGTAGAACCGCCAAAGAAGGCCATCGGTACGAATACCGCCGACAGTACCATCGCGATACCGACCAGAGCGCCCTGAATCTGCCCCATCGACTTACGGGTAGCTTCTTTTGGCGGCAAACCTTCTTCCGCCATAACACGCTCAACGTTTTCTACCACAACGATGGCGTCATCCACCAACAGGCCGATGGCGAGCACCATCCCGAACATTGTTAGCGTGTTTATCGAGAAGCCAAAGGCGGCAAGGACGGCAAAGGTCCCGAGCAATACCACCGGTACGGCAATGGTCGGAATCAACGTCGCGCGGAAGTTCTGCAGGAACAGATACATAACCAGGAACACGAGGATGATCGCTTCGACCAGCGTTTTAACCACTTCGTGAATAGAGATTTTCACGAACGGCGTGGTGTCGTATGGGTAAACAATTTTCAGACCCGACGGGAAGAACGGTTCCATCTTCGCCAGTTCAGCACGGATTGCCGCAGCGGTATCCAGCGCGTTTGCACCGGTCGCCAGCTTGATCCCCAGACCGGAAGCCGGTTGGCCGTTAAACTCTGCGATGATGTCGTAGTTCTCACCACCCAGCTCAATCTTCGCGACGTCACGCAGCAGCACGCGGGAACCATCCTGATTCACTTTCAGCAGGATTTTGCCGAACTCTTCAGTAGAGGTCAGACGCGTCTGAGCAATAATAGAGGCGTTAAGCTGTTGGCCTTTCACCGGCGGCGTACCACCGAGCTGACCCGCCGCAACCTGGGCGTTCTGCGCTTTGATGGCGGTAATGACATCAACCGGCGTTAGCTGGAATTTGTTCAGCTCATTCGGGTTCATCCAGATACGCATCGCGTACTGTGAACCGAACAACTGAACATCACCCACGCCCGACGTACGGCTGATGGCATCTTTCATATTCGCCGCCACGTAGTCGGAGATATCCTCCTGCGTCATGGTGCCATCGGTGTTGATAACGCCGACAACCATCAGGAAGCTGCTGGATGATTTCTCAACGCTCACCCCTTGCTGCTGAACTTCTTGCGGCAGCAACGGCATCGCCAGCTGCAGTTTGTTCTGCACCTGAACCTGCGCGATATCCGCATCAGTACCAGACTCAAAGGTCAGGGTGATCTGCACGGTACCCGTGGAGTCACTGTTAGAGGACATGTACATCAGGTTATCGATACCGTTCATATTCTGTTCGATAACCTGTGTCACCGTGTCCTGCACTGTTTTCGCATCAGCGCCGGGGTAGGAGGCGGAGATCGTTACTGCCGGCGGTGCAATCGTAGGATATTGCGCCACCGGCAGTTTGAGGATCGCCAGCCCCCCTGCCAACATGATGATAATGGCGATCACCCACGCAAAAATCGGGCGATCGATAAAGAAATTAGGCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_414995.1", "sequence": "MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH"}}}}}}}, "1457": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1450": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1103": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1100": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1101": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1458": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1459": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1108": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}, "39620": {"$update": {"category_aro_name": "determinant of resistance to lipopeptide antibiotics"}}}}}}, "1109": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1722": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1723": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1577": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2136": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2137": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "determinant of elfamycin resistance"}}}}}}, "1393": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "216": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "217": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "214": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "215": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "213": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "210": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "211": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1530": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "218": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "219": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2138": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2139": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "462": {"$update": {"ARO_category": {"$update": {"39620": {"$update": {"category_aro_name": "determinant of resistance to lipopeptide antibiotics"}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "939": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "4": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "938": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2550": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2396": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}, "model_param": {"$insert": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}}, "2397": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}, "model_name": "pgpB"}}, "2395": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2398": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1858": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1859": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1850": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "1851": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1852": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1853": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1854": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1855": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1856": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1857": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "919": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "918": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "915": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "914": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "917": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "916": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "911": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "910": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}, "model_name": "rphA"}}, "913": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "912": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1933": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1932": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1931": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1930": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1937": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1936": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1935": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1934": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "1939": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "847": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "846": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "845": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "844": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "843": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "842": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}}}, "841": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "840": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "849": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "848": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2406": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "1587": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2407": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1739": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1738": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1731": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "1730": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1733": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1732": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "662": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1734": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1737": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1736": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1039": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "796": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "753": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "752": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "751": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "750": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "757": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "756": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}, "39620": {"$update": {"category_aro_name": "determinant of resistance to lipopeptide antibiotics"}}}}}}, "755": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "754": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "759": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "758": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1595": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "506": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1597": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1596": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1591": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1590": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1593": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1592": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1599": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1030": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1025": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1024": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1027": {"$update": {"model_name": "tet(H)"}}, "1026": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1021": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1020": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1023": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1022": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1036": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1029": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1028": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1034": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "501": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "605": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "604": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "607": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "606": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "601": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "600": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "602": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1205": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1207": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1201": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "608": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1203": {"$update": {"ARO_category": {"$update": {"40016": {"$update": {"category_aro_name": "determinant of isoniazid resistance"}}}}}}, "1202": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "633": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1217": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1214": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1215": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "1111": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1110": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1113": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1112": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1115": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1114": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1117": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1440": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1119": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1118": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "467": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1449": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1448": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "466": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1357": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "460": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1355": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "489": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "488": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "485": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "484": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "483": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "482": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "481": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "480": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "790": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "199": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "198": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "195": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "194": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "197": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "196": {"$update": {"ARO_category": {"$update": {"40134": {"$update": {"category_aro_name": "determinant of resistance to polyamine antibiotics"}}}}}}, "191": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "190": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "193": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "192": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1454": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1107": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1456": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2383": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1105": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2387": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "2386": {"$update": {"ARO_category": {"$update": {"36406": {"$update": {"category_aro_name": "determinant of linezolid resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to linezolid antibiotics."}}, "36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}, "model_name": "cipA"}}, "1102": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1451": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1452": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1453": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "902": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "903": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "900": {"$update": {"model_name": "tet(C)"}}, "901": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "906": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "904": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "905": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1843": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1842": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "908": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "909": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1846": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1845": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1844": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2614": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}, "model_param": {"$insert": {"blastp_evalue": {"param_value": "1e-140", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}}, "1908": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1909": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1906": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1907": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1904": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1905": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1902": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1900": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1901": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "854": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "855": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "857": {"$update": {"ARO_name": "NfxB", "ARO_description": "NfxB is a repressor of the efflux pump mexCD-oprJ and itself (NfxB binds upstream of the nfxB gene and negatively regulates its own expression). Increased expression of MexCD\u2013OprJ brought about by mutations in NfxB.", "model_param": {"$insert": {"snp": {"param_type": "single resistance variant", "param_value": {"7539": "A124E"}, "clinical": {"7539": "A124E"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}, "model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "model_type_id": "41091"}}, "850": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "851": {"$update": {"ARO_category": {"$update": {"40017": {"$update": {"category_aro_name": "determinant of pyrazinamide resistance"}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "852": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "853": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "858": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "740": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "741": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "742": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "743": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "744": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "745": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "746": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "747": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "749": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1050": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1051": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1052": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1053": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1055": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1056": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1057": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1058": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1059": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1696": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1697": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1694": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1695": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1692": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "1693": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1690": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1691": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1791": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1698": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1699": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1278": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1279": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "619": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "612": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "613": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "610": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "611": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1274": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "617": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "614": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "615": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1795": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1794": {"$update": {"ARO_category": {"$update": {"40980": {"$update": {"category_aro_name": "determinant of resistance to nucleoside antibiotics"}}}}}}, "1472": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1473": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1470": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1476": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1477": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1474": {"$update": {"ARO_name": "MexR", "ARO_description": "MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM.", "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"7614": "N53D", "7615": "H107P"}}, "clinical": {"$insert": {"7614": "N53D", "7615": "H107P"}}}}}}, "model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "model_type_id": "41091"}}, "1475": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1478": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1479": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1304": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1305": {"$update": {"model_name": "OprM", "ARO_name": "OprM"}}, "1306": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1307": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1300": {"$update": {"model_name": "MexF", "ARO_name": "MexF"}}, "1301": {"$update": {"ARO_category": {"$update": {"39620": {"$update": {"category_aro_name": "determinant of resistance to lipopeptide antibiotics"}}}}}}, "1303": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1308": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1309": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "498": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "499": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "494": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "495": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "496": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "497": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "490": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "491": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "492": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "493": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "24": {"$update": {"ARO_category": {"$update": {"39458": {"$update": {"category_aro_name": "determinant of fusidic acid resistance"}}}}}}, "25": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "26": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "27": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "20": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "21": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "22": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "23": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "28": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "29": {"$update": {"ARO_category": {"$update": {"36547": {"$update": {"category_aro_name": "determinant of sulfonamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to sulfonamide antibiotics."}}}}, "model_name": "Escherichia coli folP with mutation conferring resistance to sulfonamides"}}, "1241": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "7": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2281": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "2282": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "2283": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "2284": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}, "$insert": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}}, "model_name": "Escherichia coli murA with mutation conferring resistance to fosfomycin"}}, "2375": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2372": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}, "model_name": "Escherichia coli GlpT with mutation conferring resistance to fosfomycin", "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "2373": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}, "model_name": "Escherichia coli UhpT with mutation conferring resistance to fosfomycin"}}, "1087": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1086": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1876": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1877": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1874": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1875": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1872": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1873": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "1870": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1871": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1083": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1878": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1879": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "977": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "976": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "975": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "973": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "972": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "970": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1080": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "979": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "978": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2119": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "180": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "181": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "186": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "187": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "184": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "185": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2110": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2111": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "188": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2113": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2114": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2115": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2116": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2117": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1919": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1918": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1911": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1910": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1913": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1912": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1915": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1914": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1917": {"$update": {"model_name": "tet(30)"}}, "1916": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "868": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "189": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "861": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "860": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "863": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "862": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "865": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "864": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "867": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2024": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2025": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2026": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2027": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2020": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "2021": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2022": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2023": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2028": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2029": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1502": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "883": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "882": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "881": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "880": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "887": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "886": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "885": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "884": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "889": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "888": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "775": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "774": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "776": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "771": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "770": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "773": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "772": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "779": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "778": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "77": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "76": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "75": {"$update": {"ARO_category": {"$update": {"39458": {"$update": {"category_aro_name": "determinant of fusidic acid resistance"}}}}}}, "74": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "73": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "72": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "71": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "70": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "79": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "78": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1043": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1042": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1041": {"$update": {"ARO_name": "MexS", "model_param": {"$insert": {"snp": {"param_type": "single resistance variant", "param_value": {"7573": "V104A", "7575": "D44E", "7574": "F253L", "7577": "F185L", "7576": "S60F", "7579": "L270Q", "7578": "V73A", "7580": "C245G", "7581": "A166P", "7582": "S60P", "7583": "L263Q"}, "clinical": {"7573": "V104A", "7575": "D44E", "7574": "F253L", "7577": "F185L", "7576": "S60F", "7579": "L270Q", "7578": "V73A", "7580": "C245G", "7581": "A166P", "7582": "S60P", "7583": "L263Q"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}}, "model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "model_name": "MexS", "model_type_id": "41091"}}, "1040": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1047": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1045": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1044": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1049": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1048": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1681": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1683": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1682": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1685": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1684": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1687": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1686": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1689": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1688": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1269": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1268": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "669": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "668": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "667": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1262": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "665": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "664": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1267": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1266": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1265": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "660": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}, "model_name": "Streptococcus pneumoniae parC conferring resistance to fluoroquinolone"}}, "640": {"$update": {"model_name": "tet(31)"}}, "1469": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "determinant of elfamycin resistance"}}}}}}, "1468": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1465": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1464": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1467": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1466": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1461": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1460": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "1463": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1019": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1317": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1316": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1314": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1312": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1311": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1310": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1319": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1010": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "464": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1011": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "319": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "318": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "313": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "312": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "311": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "310": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "317": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "316": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "315": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "314": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1335": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1334": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1336": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1331": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1333": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1332": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2298": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2292": {"$update": {"ARO_category": {"$update": {"36616": {"$update": {"category_aro_name": "determinant of aminocoumarin resistance"}}}}}}, "2291": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}, "$insert": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}}, "model_name": "Chlamydia trachomatis intrinsic murA conferring resistance to fosfomycin"}}, "2290": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}, "$insert": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}}, "model_name": "Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin"}}, "2294": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}, "model_name": "Campylobacter jejuni gyrA conferring resistance to fluoroquinolones"}}, "1521": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1861": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1860": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1863": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1862": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1865": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1864": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1867": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1866": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1869": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1868": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "964": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "965": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "966": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "967": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "960": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "961": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "962": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "963": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "968": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "969": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2109": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2108": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "determinant of elfamycin resistance"}}}}, "model_name": "Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A"}}, "2103": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2102": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2100": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2106": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2105": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2104": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "30": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "635": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1560": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "641": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "878": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "879": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "877": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "874": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "875": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "872": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "643": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "870": {"$update": {"model_name": "otr(B)"}}, "871": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2037": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "2036": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2035": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1242": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2032": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2031": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2030": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "9": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "645": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2039": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "644": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "890": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "891": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "892": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "893": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}}}}}, "894": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "895": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "896": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "897": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "898": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "899": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "646": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1249": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1964": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1965": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1788": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1789": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "768": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "769": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1780": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1781": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "760": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "761": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "766": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "767": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "764": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "765": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1962": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1963": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1078": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1079": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1076": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1077": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1074": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1075": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1072": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1073": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1070": {"$update": {"ARO_category": {"$update": {"36547": {"$update": {"category_aro_name": "determinant of sulfonamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to sulfonamide antibiotics."}}}}}}, "1071": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1678": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}, "36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1679": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1674": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1675": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1676": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1677": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1670": {"$update": {"model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"7533": "G71E"}}, "clinical": {"$insert": {"7533": "G71E"}}}}}}, "model_type_id": "41091"}}, "1671": {"$update": {"model_name": "Salmonella serovars soxS with mutation conferring antibiotic resistance", "ARO_name": "Salmonella serovars soxS with mutation conferring antibiotic resistance"}}, "1672": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1673": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1094": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1095": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1096": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1097": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1090": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1091": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1092": {"$update": {"model_name": "tet(39)"}}, "1093": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "674": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "675": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "676": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "677": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1098": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1099": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "672": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "673": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1418": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1419": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1410": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1411": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1412": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1413": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1414": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1415": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1416": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1417": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1322": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1323": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1320": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}}}, "1321": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1326": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1327": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1324": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1325": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1328": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1329": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "5": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1531": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1524": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1257": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1254": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1255": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1520": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1253": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1250": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1251": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1528": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1529": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1258": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1259": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "308": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "309": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "300": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "301": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "302": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "303": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "304": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "305": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "306": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "307": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1792": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "473": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "_timestamp": "2017-04-05T18:43:39+00:00", "2478": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "470": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "471": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1898": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1899": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1895": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1896": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1897": {"$update": {"model_name": "tet(L)"}}, "1890": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1891": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1892": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1893": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "959": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "958": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2134": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2135": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2132": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2133": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "2131": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "951": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "950": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "952": {"$update": {"ARO_category": {"$update": {"36547": {"$update": {"category_aro_name": "determinant of sulfonamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to sulfonamide antibiotics."}}}}}}, "955": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "954": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "957": {"$update": {"model_name": "tet(G)"}}, "956": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "477": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "2002": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "2003": {"$update": {"model_name": "pmrA"}}, "2000": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2001": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2006": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2007": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2004": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2005": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2008": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2009": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2034": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1263": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "666": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1799": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1798": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "719": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "718": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "717": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "663": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "715": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "714": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "713": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "712": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "711": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "710": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "661": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "716": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "505": {"$update": {"ARO_category": {"$update": {"40134": {"$update": {"category_aro_name": "determinant of resistance to polyamine antibiotics"}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "1069": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1068": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1061": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1060": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1063": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1062": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1065": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1064": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1067": {"$update": {"model_name": "MexE", "ARO_name": "MexE"}}, "1066": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1669": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1668": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1667": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1666": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1663": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1662": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1661": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1660": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "591": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "590": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1085": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1084": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "595": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "594": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1081": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "596": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "599": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "598": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1089": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1088": {"$update": {"ARO_category": {"$update": {"39620": {"$update": {"category_aro_name": "determinant of resistance to lipopeptide antibiotics"}}}}}}, "1526": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1409": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1408": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1403": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1402": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1400": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1407": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1406": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1405": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1404": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1546": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "449": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "448": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1339": {"$update": {"ARO_category": {"$update": {"40134": {"$update": {"category_aro_name": "determinant of resistance to polyamine antibiotics"}}}}}}, "1338": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1547": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "443": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "442": {"$update": {"ARO_name": "OpmD"}}, "441": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "440": {"$update": {"model_name": "MexA", "ARO_name": "MexA"}}, "447": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "446": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "445": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "444": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1545": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1543": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "39": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "38": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1540": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "32": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "31": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "695": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "36": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "35": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "34": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1537": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1240": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}, "model_name": "Bacillus Cluster A intrinsic mph"}}, "1243": {"$update": {"model_sequences": {"$update": {"sequence": {"4035": {"dna_sequence": {"fmax": "2531", "fmin": "1625", "accession": "D16251.1", "strand": "-", "sequence": "TCATTCCGCTGCGGCGAGCTGCGCCTTCGCCGCAGCGAGGTACTCTTCGTTACCCGAGTCGAGGGCGAAGAGTGCGTAGGTGACCGCCCCGAACGCAAGGCGCTCCGCGATGTGGTGGGCGAGCCGCGGCCACACCCGGCCACCGGCCGCTTCATACGTGAGGAGGAGCTTCGCGAGCCCCTCTTCACCAAAGACCATAAGGTGCGCGGCCATGTCGATGGCAGGGTCATCAACGCGGGCCTCGCTCCAGTCGATCATCCCGCTGACGCGCTCCGTGTTGTCGATGAGCACATGGCCCACGTAGAGATCGCCATGCACCACCACGGAGAAATCTGGCCACGACGAATCGTCGTCGAGCCAGCGCTGCCACCGGTGGAGGCGCTTGTCGTTCACCACGAACTCGCGTCGGACGCGGTCAACGTCGTCGGCCACCTTCTGACGGGCCTGCGTCGGTGTACGGATGAGCATCCCCGCATCCACGGCGGCGGAAATGGGGACGGCATGCAGGGCGGCGAGCGCGGTCGCGAAGCTCTCCGCGAAGACCTCCGAGTCCTGCGGCACGACCCAGTCGGGCGTGGACGAACCAGGCTGGATGACCATCGCAGTCGAGTCTTCGAGCATGGGATAGGCAACGAGCTCGGCGTTGGCCACGCGCCAGTCCGGCACCGCGAACGGCAGGCGATTCTTGAGCATTGCCAGCACCCGCGCCTCTGGTTCGACCTTCGCGCTTACCTCGGCTCGGCGCGGGATGCGCAGCACCCACCGACGTCCATCGTCGACGGTGGCGATCACGATCCTATAGTCGAGCCCAAGCTCATTGACAGTCAGCGGGCCATGGAGCTTGAGCCCATGTCGGGCTGCAAGTGCGTACAGTTGGGAGGTATCGGCGGTCGTGACTACGGTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"GI": "BAA03776.1", "sequence": "MTVVTTADTSQLYALAARHGLKLHGPLTVNELGLDYRIVIATVDDGRRWVLRIPRRAEVSAKVEPEARVLAMLKNRLPFAVPDWRVANAELVAYPMLEDSTAMVIQPGSSTPDWVVPQDSEVFAESFATALAALHAVPISAAVDAGMLIRTPTQARQKVADDVDRVRREFVVNDKRLHRWQRWLDDDSSWPDFSVVVHGDLYVGHVLIDNTERVSGMIDWSEARVDDPAIDMAAHLMVFGEEGLAKLLLTYEAAGGRVWPRLAHHIAERLAFGAVTYALFALDSGNEEYLAAAKAQLAAAE"}}}}}, "ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "642": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1533": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1244": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "647": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1246": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "649": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "648": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1539": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1538": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "339": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "338": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "335": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "334": {"$update": {"ARO_name": "MexX"}}, "337": {"$update": {"model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "850"}}}, "$insert": {"blastp_evalue": {"param_value": "1e-120", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}}, "336": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}, "model_name": "tlrB conferring tylosin resistance"}}, "331": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "330": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "333": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "332": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "8": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1462": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1889": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1888": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1887": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1886": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1885": {"$update": {"model_name": "tet(Z)"}}, "1884": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1883": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1882": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1881": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2121": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2122": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2124": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "determinant of elfamycin resistance"}}}}}}, "948": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "949": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "946": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "947": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "945": {"$update": {"model_name": "tet(40)"}}, "942": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "943": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "940": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "941": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2410": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "133": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "132": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "131": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "130": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "137": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "136": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "135": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "134": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "139": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2019": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2018": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2015": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2014": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}}}, "2017": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2016": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2011": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2010": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2013": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "2012": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1793": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "934": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "708": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "709": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "704": {"$update": {"model_name": "OprJ", "ARO_name": "OprJ"}}, "705": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "706": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "707": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "700": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "701": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "702": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "703": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}, "model_param": {"$insert": {"blastp_bit_score": {"param_value": "700", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}}}}, "88": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "89": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "82": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "83": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "80": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "81": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "86": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "87": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "84": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "85": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "762": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1658": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1659": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1652": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1653": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1650": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1651": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1656": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1657": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1654": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1655": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "586": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "587": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "584": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "585": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "763": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "583": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "580": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "512": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1984": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "588": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "589": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1985": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1982": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1983": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1436": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1434": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1432": {"$update": {"ARO_category": {"$update": {"40134": {"$update": {"category_aro_name": "determinant of resistance to polyamine antibiotics"}}}}}}, "1433": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1430": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1431": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "418": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1981": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1438": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1439": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1260": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "458": {"$update": {"model_name": "tet(B)"}}, "459": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "450": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "451": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "452": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1343": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1344": {"$update": {"ARO_name": "MexH"}}, "1345": {"$update": {"model_name": "tet(K)"}}, "1346": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "457": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1082": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "517": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "656": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "657": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "654": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "655": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1506": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "653": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "650": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1505": {"$update": {"ARO_category": {"$update": {"40980": {"$update": {"category_aro_name": "determinant of resistance to nucleoside antibiotics"}}}}, "model_name": "SAT-4"}}, "1508": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1509": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "658": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "516": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}}}, "1992": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "2127": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2126": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2129": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2128": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1376": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "322": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "323": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "320": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}, "model_name": "Streptococcus pneumoniae PBP2x conferring resistance to amoxicillin"}}, "321": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "326": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "327": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "324": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "325": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "329": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2330": {"$update": {"ARO_category": {"$update": {"36547": {"$update": {"category_aro_name": "determinant of sulfonamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to sulfonamide antibiotics."}}}}}}, "2331": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2332": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "2333": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2335": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1594": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1341": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1995": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2482": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1598": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2248": {"$update": {"ARO_category": {"$update": {"39458": {"$update": {"category_aro_name": "determinant of fusidic acid resistance"}}}}}}, "2249": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "2244": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "2245": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}, "model_name": "vanKI"}}, "2246": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}, "model_name": "vanRI"}}, "2240": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "2241": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}, "model_name": "vanI"}}, "2242": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "2243": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}, "model_name": "vanXI"}}, "995": {"$update": {"ARO_name": "MexG"}}, "994": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "997": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "996": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "991": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "990": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "993": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "992": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "999": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "998": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "120": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "122": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "123": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "124": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "125": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "126": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "127": {"$update": {"ARO_category": {"$update": {"36406": {"$update": {"category_aro_name": "determinant of linezolid resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to linezolid antibiotics."}}, "36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "129": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "2068": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}, "40134": {"$update": {"category_aro_name": "determinant of resistance to polyamine antibiotics"}}}}}}, "2069": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2060": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "2061": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2062": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "2063": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2064": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2065": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2066": {"$update": {"model_name": "Escherichia coli soxS with mutation conferring antibiotic resistance", "ARO_name": "Escherichia coli soxS with mutation conferring antibiotic resistance"}}, "2666": {"$update": {"ARO_category": {"$update": {"40016": {"$update": {"category_aro_name": "determinant of isoniazid resistance"}}, "40348": {"$update": {"category_aro_name": "determinant of triclosan resistance"}}}}, "model_param": {"$insert": {"blastp_evalue": {"param_value": "1e-60", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}}, "2660": {"$update": {"model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "760"}}}, "$insert": {"blastp_evalue": {"param_value": "1e-200", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}}, "1749": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1397": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1645": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1644": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1647": {"$update": {"ARO_name": "MexI"}}, "1646": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1641": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1640": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1643": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}}}, "1642": {"$update": {"ARO_category": {"$update": {"36406": {"$update": {"category_aro_name": "determinant of linezolid resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to linezolid antibiotics."}}, "36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1396": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1649": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1648": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1742": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1743": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "578": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "573": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "572": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "571": {"$update": {"ARO_category": {"$update": {"36406": {"$update": {"category_aro_name": "determinant of linezolid resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to linezolid antibiotics."}}, "36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "570": {"$update": {"ARO_category": {"$update": {"36547": {"$update": {"category_aro_name": "determinant of sulfonamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to sulfonamide antibiotics."}}}}, "model_name": "Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides"}}, "577": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "576": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "575": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "574": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1209": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1208": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1421": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1420": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1423": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1422": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1425": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "1424": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1426": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1429": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1428": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2404": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "731": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "730": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2405": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "735": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "734": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "737": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "736": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "739": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "738": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1359": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1358": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "469": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "468": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1353": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1352": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1351": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1350": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "461": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1356": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "463": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1354": {"$update": {"ARO_category": {"$update": {"40134": {"$update": {"category_aro_name": "determinant of resistance to polyamine antibiotics"}}}}}}, "1273": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}, "model_name": "otr(A)"}}, "2158": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "determinant of elfamycin resistance"}}}}}}, "1519": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1518": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "1515": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1514": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1517": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1516": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1511": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1510": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1513": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1512": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1735": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1275": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1004": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "280": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "582": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "357": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "356": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "355": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "354": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "353": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "352": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "351": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "359": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "358": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1033": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1447": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2321": {"$update": {"model_name": "cdeA"}}, "2326": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2325": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "1446": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2329": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2328": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "289": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "288": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1444": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "281": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1443": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "283": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "282": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "285": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "287": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "286": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1441": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}, "model_name": "Enterobacter aerogenes omp36 with mutation"}}, "1116": {"$update": {"ARO_category": {"$update": {"36522": {"$update": {"category_aro_name": "determinant of rifamycin resistance", "category_aro_description": "Enzymes, other proteins, or other gene products shown clinically to confer resistance to rifamycin (rifampin) antibiotics."}}}}}}, "263": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "262": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "261": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "260": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "267": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "266": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "265": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "264": {"$update": {"model_param": {"$insert": {"blastp_bit_score": {"param_value": "850", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}}}}, "269": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "268": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1562": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1563": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1564": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1565": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1566": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "2259": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "2257": {"$update": {"ARO_category": {"$update": {"37710": {"$update": {"category_aro_name": "determinant of elfamycin resistance"}}}}, "model_param": {"$insert": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}}}}, "1567": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "2251": {"$update": {"ARO_category": {"$update": {"39418": {"$update": {"category_aro_name": "determinant of polymyxin resistance"}}}}, "model_param": {"$update": {"40334": {"$update": {"param_description": "A parameter to describe the mapped insertion or deletion. For an insertion: insert the location and genetic sequence of the insertion. For a deletion: insert the location of the deletion. For nucleotide space: insertion:  [nt][position]+[number of nucleotides]:[nucleotides] eg. nt312+1:G. For protein space: insertion: +[amino acids][start position:end position] eg. +S3:12. If both are known, a \"/\" may be used to separate the protein and nucleotide notation eg. nt312+3:AGC/+S312."}}}}}}, "988": {"$update": {"model_name": "tet(J)"}}, "989": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "982": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "983": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "980": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "981": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "987": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "984": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "985": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "115": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "114": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1790": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "116": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "111": {"$update": {"ARO_category": {"$update": {"36616": {"$update": {"category_aro_name": "determinant of aminocoumarin resistance"}}}}}}, "110": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "113": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "112": {"$update": {"ARO_category": {"$update": {"36410": {"$update": {"category_aro_name": "determinant of fosfomycin resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fosfomycin antibiotics."}}}}}}, "119": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "118": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1797": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "2079": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2078": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2073": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2072": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "2071": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2070": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2077": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2076": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "2075": {"$update": {"model_name": "Salmonella enterica soxR with mutation conferring antibiotic resistance", "ARO_name": "Salmonella enterica soxR with mutation conferring antibiotic resistance"}}, "2074": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1796": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1035": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}, "model_name": "Streptococcus pneumoniae PBP2b conferring resistance to amoxicillin"}}, "1389": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1630": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1631": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1632": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1633": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1634": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1635": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1636": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1637": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1638": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1639": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1988": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1989": {"$update": {"model_name": "Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance", "ARO_name": "Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance"}}, "568": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "569": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "560": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "561": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "562": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "563": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "564": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "565": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "566": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "567": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1188": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1189": {"$update": {"ARO_category": {"$update": {"36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "1186": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1187": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1184": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1185": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1182": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1183": {"$update": {"ARO_category": {"$update": {"36611": {"$update": {"category_aro_name": "determinant of tetracycline resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to tetracycline antibiotics or tetracycline-like derivatives."}}}}}}, "726": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "727": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "724": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "725": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "722": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "723": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "720": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "721": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1745": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1746": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1747": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1740": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1741": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "728": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "729": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1164": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1165": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1166": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1160": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1162": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1163": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1168": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1169": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "48": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "49": {"$update": {"ARO_category": {"$update": {"37131": {"$update": {"category_aro_name": "determinant of resistance to peptide antibiotics"}}}}}}, "46": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "47": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "42": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "43": {"$update": {"model_name": "tet(42)"}}, "40": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "41": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1568": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1569": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1299": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1292": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1293": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1290": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1291": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1296": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1297": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1294": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1295": {"$update": {"ARO_category": {"$update": {"36191": {"$update": {"category_aro_name": "determinant of phenicol resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to phenicol (chloramphenicol) antibiotics. These include chloramphenicol acetyltransferase (CAT) enzymes, which are found in a large number of species."}}}}}}, "1713": {"$update": {"ARO_category": {"$update": {"36633": {"$update": {"category_aro_name": "determinant of resistance to glycopeptide antibiotics", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to glycopeptide antibiotics."}}}}}}, "1360": {"$update": {"ARO_category": {"$update": {"36616": {"$update": {"category_aro_name": "determinant of aminocoumarin resistance"}}}}}}, "1712": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "475": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1711": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1381": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1710": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}, "1717": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1716": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1715": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "732": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1714": {"$update": {"ARO_category": {"$update": {"36380": {"$update": {"category_aro_name": "determinant of lincosamide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to lincosamide antibiotics."}}, "36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}, "36379": {"$update": {"category_aro_name": "determinant of streptogramin resistance", "category_aro_description": "Ezymes, other proteins or other gene products shown clinically to confer resistance to streptogramin antibiotics."}}}}}}, "472": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1367": {"$update": {"ARO_category": {"$update": {"36454": {"$update": {"category_aro_name": "determinant of macrolide resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to macrolide antibiotics."}}}}}}, "1364": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1365": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "1362": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1363": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "474": {"$update": {"ARO_category": {"$update": {"40990": {"$update": {"category_aro_name": "determinant of diaminopyrimidine resistance"}}}}}}, "1361": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "478": {"$update": {"ARO_category": {"$update": {"36243": {"$update": {"category_aro_name": "determinant of aminoglycoside resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to aminoglycoside antibiotics."}}}}}}, "479": {"$update": {"ARO_category": {"$update": {"36268": {"$update": {"category_aro_name": "determinant of beta-lactam resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to beta-lactam antibiotics."}}}}}}, "1369": {"$update": {"ARO_category": {"$update": {"36241": {"$update": {"category_aro_name": "determinant of fluoroquinolone resistance", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to fluoroquinolone antibiotics"}}}}}}}, "$delete": ["2327", "2319", "2420", "733", "2419", "2418"], "$insert": {"2734": {"model_id": "2734", "ARO_accession": "3004077", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "900", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G.", "model_sequences": {"sequence": {"4054": {"dna_sequence": {"fmax": "1473980", "fmin": "1472546", "accession": "NC_002516.2", "strand": "-", "sequence": "CTACCGGCCAAGGACTGAGGCGGCCTCCGCGTCCTCCCGCTGCAGGCGCTCGTGCTGGCGGATGAAGCGCCGCGCGCTGCGCGCCAGGCGGATGCAGAGCATGATCGCCGCGCCGGTCAGGCCCACCACCAGGCCTTGCCACAGACCGCGCGGTCCGGTGGGTTCCTGGAACCAGTCGGTGAGGCCGAGGCTGTAGCCCACCGGCAGGCCGATGCCCCAGTAGGCGAACAGGGTCATGATCATCGTCACCCGGGTGTCCTGGTAGCCGCGCAGGGCCCCGGCGGCGGTGACCTGCAGGGCGTCGGAGAACTGGAACAGCGCGGAGAACACGATCAGCGAGGCGGCGATGGCGATCACCGCCGGGTCCGGCGAATACATCGCGGCGATCTGCTCGCGCAGCAACAACATCAGGCTCGCCGAGACGCAGGCGTAGCCCAGCGCCGCGGCCATCCCCACGCCGGCGGCGAAGCGCGCGTCGCGCGGCAGGCCGGCGCCGAGGTTGTGGCCGACCCGCACGGTCACCGCCATCCCCAGCGAATAGGGAATCATGAACACCAGCGCGCTGAAGTTCAGGGCGATCTGGTGGCCGGCCACCACGTTCTCGTCGAGCCCGCCGATCAGCAGGGCGATCACCGAGAAGATGCTCGACTCGGCGAACACCGCGATGCCGATCGGCAGGCCGACCGCCACCAGCGGGCCGATGGTCGCGCGATCCGGCCACTCCCAGCGCGAGAACAACTGGCTGGCGCGGTAGATCGAGGCCTTGTTCACCCAGAACAGCATGCCGAGGAACATGAACCACATCACCGAGCCGGTGGCCCAGCCGCAGCCGGGGCCACCCATCTTCGGCATGCCGAAGTGGCCGTAGATCAGCGCGTAGTTGATCGGGATGTTCAGCAGCAGCCCGCCGATCCCCAGCACCATGCTCGGCCGGGTCCGTCCCAGGCCGTTGGTGTAGCAGCGCAGTACGTGGTACAGCGCCGCCGCCGGGAAGCCCAGGGCGATGCCCTTGAGGTACAGCAGGCTCGGCCCGATCAGTTCCGGGCGCACTTTCATCAAGCCGAGGATCGGCTCCGACAACCACCACAGCACCGCCCCCGACAGCGGTCCGATCAGCAGCGCCAGCCACAGCGCCTGGCGCACCAGCGGCCCGGTGCCGGGCTGGTCGCCGGCGCCATGGCGCTGGGCGACCTTGGCCGTGGTGGCGAGCAGGGTGCCGGTCATCAGCAGGAACATCGGGATCCAGATGGAGTTGCCCAGCGCCACCGCTGCCAGGTCGTGCGGACTGGCGCGCCCGGCCATCACCGCATCGACGAAGCCCATGGCGGTGGTCGCCAGTTGCGCGATCATGATCGGCGCGGCGAGGGTCAGCAGTTCCTTGAGTTCGGCGCGGATGCGCAAGCCACGGGAAAGGGGCAGGGCGGGGCTGTTCAC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_250052.1", "sequence": "MNSPALPLSRGLRIRAELKELLTLAAPIMIAQLATTAMGFVDAVMAGRASPHDLAAVALGNSIWIPMFLLMTGTLLATTAKVAQRHGAGDQPGTGPLVRQALWLALLIGPLSGAVLWWLSEPILGLMKVRPELIGPSLLYLKGIALGFPAAALYHVLRCYTNGLGRTRPSMVLGIGGLLLNIPINYALIYGHFGMPKMGGPGCGWATGSVMWFMFLGMLFWVNKASIYRASQLFSRWEWPDRATIGPLVAVGLPIGIAVFAESSIFSVIALLIGGLDENVVAGHQIALNFSALVFMIPYSLGMAVTVRVGHNLGAGLPRDARFAAGVGMAAALGYACVSASLMLLLREQIAAMYSPDPAVIAIAASLIVFSALFQFSDALQVTAAGALRGYQDTRVTMIMTLFAYWGIGLPVGYSLGLTDWFQEPTGPRGLWQGLVVGLTGAAIMLCIRLARSARRFIRQHERLQREDAEAASVLGR"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "PmpM", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "41170", "model_name": "PmpM", "model_type_id": "40292"}, "2712": {"model_id": "2712", "ARO_accession": "3003038", "ARO_name": "MexXY-OprA", "ARO_description": "MexXY-OprA is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprA is the outer membrane channel. MexXY-OprA is associated with resistance to aminoglycosides", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7589": "2223,334,1786,1570"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "39472", "model_name": "MexXY-OprA", "model_type_id": "41112"}, "2711": {"model_id": "2711", "ARO_accession": "3003032", "ARO_name": "MexXY-OprM", "ARO_description": "MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7588": "2223,334,1786,1305"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "39466", "model_name": "MexXY-OprM", "model_type_id": "41112"}, "2716": {"model_id": "2716", "ARO_accession": "3004072", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "950", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "OpmB is an outer membrane efflux protein in Pseudomonas aeruginosa that shows functional cooperation with MuxABC, to form the efflux pump system MuxABC-OpmB.", "model_sequences": {"sequence": {"4041": {"dna_sequence": {"fmax": "2847779", "fmin": "2846282", "accession": "NC_002516.2", "strand": "-", "sequence": "TCAGGGCGAAGGCGGCAGGCCCTCTTCGACCCGGCCGAGCCGCTCGTCGGTCCGCTCGATGTCGGCGCTGTCCCAGCCGCCGCCCATTGCCGCGATCAACTGGACGCTGGCGGTCAGGCGGCTGCCGAGCAGGGTCAGCACGGTGCGTTCGTTGCTCAGCGCGGTGGCCTGGTTGGTGACCACGTCGGTGTAGTCGACGGTGCCGGCCTTGTACTGGTTCTCGGCCAGGCGCAGTGCCTCGCGGGCCGACTCCAGGGCTTCGCGCTGCACCCCGCTCTCCTCGTCGAGGACGCTCAATTGCACCAGGTAGTCCTCCACCTCGCGGAAACCGTCGAGCACGGTCTGCCGGTAGGTCGCCACGGTCTGGTCGTAGGTAGCCTCGGCCTGGTCCACCTGGGAGCCGATCAGGCCGCCGTCAAACAGGGTCATGGCGAACTGCGGGCCGATCGACCAGAAGCGGTTCGGCGTGCTGATCCAGTTGCTCAGGCTGCCGCTGCGGTAGCCGCCGGCGGCGCTCAGGGTGAGGTCGGGGAAATAGGCGGCCTTGGCCACGCCGATCTGGGCGTTGGCGGAAATCACCTTGCGTTCCGCCGAGGCGATGTCCGGCCGTCGTTCGAGCAATTGCGACGGCACCACTGCCGGCAGGTCCGGCAGCTTCGGCACGCTCGCCACCGGCGGCAGGTTGAATTGCGCCGGCGGCAGGCCGACCAGCACGGCGATGGCGTGCTCCAGCTGGGCACGCTGGTACTTCAGGTCGATGGCCTGGGCCTGGGTGCTTTTCAACTGGGTGCGGGCCTGGGCCACGTCGGCCCTGGTGACGATGCCGGCGCGGTATTTGTTCTCGGCCACCTTCAGCGAACGCTCGTAGGCCGTCACCGTGTCGTTGAGCAGGCGGATCTGTTCGTCCATCACCCGCAGTTGCAGGTAGTTCTGCGCCAGTTGCGACTGCTGGCTGAGGCGCACCGCGGCGAGGTCGGCGGCGCTGGCATGCAGGCTCGCCTGGTTGGCCTCCAGTTGCCGGCGCAGCTTGCCCCAGAGGTCGACCTCCCAGCTGACACTGAGGTTGGTCGAGTAGCTGGTGCTGATCGCGCCAGAGCCGCCGCTGCTCACCGTCGAGCCTCCCGGCAGCAACACGGTGCTGTCGCCGCCGCCCTGGCCGCTGCGGGTCTTGCCCACGTTGCCGGTGATCGACGGGAAGAACGCCGCCCGCGCGCCGCGCACCAGCGCCTCGGCCTGGCGGAACTGCGCCACCGACTGGGCCAGGGTCTGGTTGGAACGTTCCAGGTGCATCTGCAGGTCGTTCAGGGTCTGGTCGCCGTACAGCTCCCACCAGGCGCCGCGCTGGAACACGTCGCGCGGCTCGGCGCGGCGCCAGCCTTCGGCTTCCTTGAATTCGGCGGGCACCGCCAGGTCCGGTCGCTGGTAGTCGGGGCCGATGGCGCAGCCGCCGAGGGCGGCGACCAGGGCCAGGGCGAGCAACGAGGGGGTGTGTTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_251215.1", "sequence": "MKHTPSLLALALVAALGGCAIGPDYQRPDLAVPAEFKEAEGWRRAEPRDVFQRGAWWELYGDQTLNDLQMHLERSNQTLAQSVAQFRQAEALVRGARAAFFPSITGNVGKTRSGQGGGDSTVLLPGGSTVSSGGSGAISTSYSTNLSVSWEVDLWGKLRRQLEANQASLHASAADLAAVRLSQQSQLAQNYLQLRVMDEQIRLLNDTVTAYERSLKVAENKYRAGIVTRADVAQARTQLKSTQAQAIDLKYQRAQLEHAIAVLVGLPPAQFNLPPVASVPKLPDLPAVVPSQLLERRPDIASAERKVISANAQIGVAKAAYFPDLTLSAAGGYRSGSLSNWISTPNRFWSIGPQFAMTLFDGGLIGSQVDQAEATYDQTVATYRQTVLDGFREVEDYLVQLSVLDEESGVQREALESAREALRLAENQYKAGTVDYTDVVTNQATALSNERTVLTLLGSRLTASVQLIAAMGGGWDSADIERTDERLGRVEEGLPPSP"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "OpmB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "41154", "model_name": "OpmB", "model_type_id": "40292"}, "2731": {"model_id": "2731", "ARO_accession": "3003691", "ARO_name": "MexJK-OpmH", "ARO_description": "MexJK-OpmH is a triclosan efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OpmH is the outer membrane efflux protein. MexJK is constitutively expressed in mexL mutants.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7607": "2205,2206,2219,2195"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "40339", "model_name": "MexJK-OpmH", "model_type_id": "41112"}, "2732": {"model_id": "2732", "ARO_accession": "3003029", "ARO_description": "MexVW-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexV is the membrane fusion protein; MexW is the RND-type membrane protein; and OprM is the outer membrane channel. MexVW-OprM is associated with resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin and acriflavine.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "MexVW-OprM", "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "39463", "model_name": "MexVW-OprM", "model_type_id": "41112"}, "2733": {"model_id": "2733", "ARO_accession": "3003678", "ARO_name": "TriABC-OpmH", "ARO_description": "TriABC-OpmH is a triclosan-specific efflux pump expressed in the Gram-negative Pseudomonas aeruginosa. TriABC is the only P. aeruginosa resistance nodulation cell division (RND) pump which contains two membrane fusion proteins, TriA and TriB, and both are required for efflux pump function. TriABC associated with OpmH assemble a functional triclosan efflux pump.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7609": "2192,2193,2194,2195"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "40313", "model_name": "TriABC-OpmH", "model_type_id": "41112"}, "2718": {"model_id": "2718", "ARO_accession": "3004074", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "2000", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "MuxB is one of the two necessary RND components in the Pseudomonas aeruginosa efflux pump system MuxABC-OpmB.", "model_sequences": {"sequence": {"4043": {"dna_sequence": {"fmax": "2854014", "fmin": "2850882", "accession": "NC_002516.2", "strand": "-", "sequence": "TCATCGCCCGGCGTCCCCGTCGAACCCGGCCTCGGTGTTCAGGTCCAGCCCGCGCTGCTTGCGCCAGGCCGCCCAGCGACGGGCCAGGCGGTCGAAGTAGAGATAGATCACCGGGGTGGTGAACAGGGTCAGGACCTGGCTCAGCAGCAGGCCACCGACCATGGTGATGCCCAGCGGCTGGCGCAGCTCGGCGCCGGCGCCGCCGGCGAGCATCAGCGGCAGCGCGCCGAGCAGCGCGGCCATGGTGGTCATCAGGATCGGCCGGAAGCGCAGCAGGCAGGCCTGGTAGATCGCCTCATGGGGCGGCTTGCCTTCGTTGCGCTCGGCGTCGAGGGCGAAATCGATCATCATGATCGCGTTCTTCTTGACGATGCCGATCAGCAGGATGATGCCGATGATCGCCACGATGCCGATCTCCTGCCCCGCCAGCATCAGCGCCAGCAGCGCGCCGACCCCGGCCGAGGGCAGGGTCGAGAGGATGGTCACCGGATGGATGAAGCTCTCGTAGAGGATGCCCAGGACGATGTACATGGTCACCACCGAGGCGAGGATCAGCAGCAGCGTGTTCGACAGCGAGGCCTCGAAGGCCAGCGCCGCGCCGCGGAAGCTGCCCTGCATGCTCAGCGGCAGCTCCAGGCTGGCCTCGACGCCACGGATCGCCTCGACCGCCTCGCCCAGGGAGTAACCCTTGGCCAGGTTGAACGACAGGGTCGCCGAGGGGAACTGGGCGATATGGTTGATCGCCAGCAGGGTATGCCGCTCCTCCACCTTCGCCAGGCTCGACAGGCGCACCTGGGTGCCGTCGCTGGACGGCACGTAGAGCTGCTCCAGGGCCTGCGGGCCGAGCTGGAACTGCGGCGCCACCTCCAGCACCACGCGGTACTGGGTGGCCTGGGTGAAGATGGTCGAGATCAGCCGCTGGCCGAAGGCGTTGTAGAGCACGCTGTCGATGTCGGAGAGCTTCACGCCGAGGCGCGAGGCGGTGTCGCGGTCGATGTTCAGGTAGGCCTGCAAGCCCTTGTCCTGCCAGTCGCTGGCGACGTCGGCGAGCTGCGGCAACTCCTGCAGCCGCGCCACCAGCTTCGGCACCCACTCGGCGAGCACGTCCGGGTCGGCGTCCTGCAAGGTGAACTGGTACTGGGTGCGGGCGACCCGGTCCTCGATGGTCAGGTCCTGCACCGGCTGCATGTACAGCTTGATCCCGGGCAGGTGGTCGAGTTCGGGCTGCAGGCGCTGGATCACTTCGCTGGCGGTGACGTCGCGCTCGCTGTGCGGCTTGAGGTTGATCAGCAGGCGGCCGGTGTTGAGGGTCGGGTTGCTGCCGTCGACGCCGATGTAGGAGGACAGGCTGGCCACCGCCGGGTCCTTCAGCACCACCTCGGCAAGGGCGCGCTGGCGCTCGGACATGGCCTGGAAGGAGATCGACTGCGGCGCTTCGGCGACGCCCTGGATCACCCCGGTGTCCTGCACCGGGAAGAAGCCCTTGGGCATGGCCAGGTAGAGTAGCGCGGTCAGCGCCAGGGTGGCGATGGCCACCAGCAGGGTCAGCGGCTGGTGCCGCAGGACCACCCGCAGGGCCTTGGCGTACTGTGCGATCAGGCCATCGATGACCCGCCCCGCGGCGCGCGCGAAGCGGCCCTGCTGGTCCTCGTCGATGTGGCGCAGCAGCTTGGCGCTGAGCATCGGCGTAAGGGTCAGGGAGACGAAGCCGGAAATCAGGATCGCCACCGCCAGGGTGATGGCGAACTCGCGGAACAGCCGCCCGGCGACGTCGCCCATGAACAGCAGCGGGATCAGCACGGCGATCAGCGAGAAAGTCAGCGAGATGATGGTGAAGCCGATCTGCTTCGAGCCCTTGAGCGCCGCTTCCAGCGGCGAGTCGCCCTGCTCCAGGTAGCGGGCGATGTTCTCCACCATGACGATCGCGTCGTCGACCACGAAGCCGGTGGCGATGGTCAGCGCCATCAGGGTCAGGTTGTTGATCGAGAAGCCGGACAGGTACATCACGCCGAAGGTACCGATCAGCGACAGCGGCACGGCGAAGCTGGGAATCAGGGTGGCGTAGACGTTGCGCAGGAACAGGAAGGTGACCATCACCACCAGCGCCACCGCCAGCGCCAGCTCGAACTGCACGTCCTTGACCGAGGCGCGGATGGTGGTGGTGCGGTCGGTCAGCACCTGCACGTCGAGATTGCCCGGCAGGGTCGATTGCAGCTGCGGCAGCAGCGCCTTGATCCGGTCGACCACCTCGATCACGTTGGCCCCCGGCTGGCGCTGGATGTTCAGCACCACCGCCGGCAGGTTGTTGGCCCAGGCGGCCAGGCGCACGTTCTCGGCGTCGTCCTCGACGCTGGCGACGTCGCGGATGCGCAGCGGCGAGCCGTTCTTGTAGGCGATGATCAGGTCGCGGTAGGCGTCGGCCGAGCGCAACTGGTCGTTGGCGTCCAGGGTCGAGGCACGGGTCGGGCCGTCGAAGCTGCCCTTGGGGCCGTTGAGGTTGTTGCTGGTCACCGTGCTGCGCAGGTCCTCCAGGCTCAGCCCCGCCGCCGCCAGCGCCGTCGGGTTGGCGCGCACCCGCACCGCCGGGCGCTGGCCGCCGCTGATGCTGACCAGGCCGACCCCGGAGATCTGCGAGATCTTCTGTGCCAGGCGGGTATCCACCAGGTCCTGGATCTGCGGCAGCGGCATGCCGTCGGACATCACCGCCAGGGTCAGGATCGGTGCGTCCGCCGGATTCACCTTGCTGAACACCGGCTGGTTCGGCAGGTCGTTGGGCAGCAGGCTCTGCGCGGCGTTGATCGCCGCCTGGACTTCCTGCTCGGCGACATCGAGGTTGCTCTGCAGGCTGAATTGCAGGGTGATCACCGAGGCGCCGCCGGAACTGCTGGAAGACATCTCGTTGAGCCCCGGAATCTGCCCGAGCTGGTTCTCCAGCGGCGCGGTGATCGACGAGGTCATGATCTCCGGGCTGGCGCCGGGGTACAGGGTGACCACCTGGATGGTCGGGTAGTCCACTTCCGGCAACGCCGAGATCGGCAGGAAGCGGTAGGCGATCAGGCCCGAGAGCAGGATCGCCACCATCAGCAGGGTGGTCGCGACCGGCCGCAGGATGAACGGGCGGGACGGGTTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_251217.1", "sequence": "MNPSRPFILRPVATTLLMVAILLSGLIAYRFLPISALPEVDYPTIQVVTLYPGASPEIMTSSITAPLENQLGQIPGLNEMSSSSSGGASVITLQFSLQSNLDVAEQEVQAAINAAQSLLPNDLPNQPVFSKVNPADAPILTLAVMSDGMPLPQIQDLVDTRLAQKISQISGVGLVSISGGQRPAVRVRANPTALAAAGLSLEDLRSTVTSNNLNGPKGSFDGPTRASTLDANDQLRSADAYRDLIIAYKNGSPLRIRDVASVEDDAENVRLAAWANNLPAVVLNIQRQPGANVIEVVDRIKALLPQLQSTLPGNLDVQVLTDRTTTIRASVKDVQFELALAVALVVMVTFLFLRNVYATLIPSFAVPLSLIGTFGVMYLSGFSINNLTLMALTIATGFVVDDAIVMVENIARYLEQGDSPLEAALKGSKQIGFTIISLTFSLIAVLIPLLFMGDVAGRLFREFAITLAVAILISGFVSLTLTPMLSAKLLRHIDEDQQGRFARAAGRVIDGLIAQYAKALRVVLRHQPLTLLVAIATLALTALLYLAMPKGFFPVQDTGVIQGVAEAPQSISFQAMSERQRALAEVVLKDPAVASLSSYIGVDGSNPTLNTGRLLINLKPHSERDVTASEVIQRLQPELDHLPGIKLYMQPVQDLTIEDRVARTQYQFTLQDADPDVLAEWVPKLVARLQELPQLADVASDWQDKGLQAYLNIDRDTASRLGVKLSDIDSVLYNAFGQRLISTIFTQATQYRVVLEVAPQFQLGPQALEQLYVPSSDGTQVRLSSLAKVEERHTLLAINHIAQFPSATLSFNLAKGYSLGEAVEAIRGVEASLELPLSMQGSFRGAALAFEASLSNTLLLILASVVTMYIVLGILYESFIHPVTILSTLPSAGVGALLALMLAGQEIGIVAIIGIILLIGIVKKNAIMMIDFALDAERNEGKPPHEAIYQACLLRFRPILMTTMAALLGALPLMLAGGAGAELRQPLGITMVGGLLLSQVLTLFTTPVIYLYFDRLARRWAAWRKQRGLDLNTEAGFDGDAGR"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "MuxB", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "41156", "model_name": "MuxB", "model_type_id": "40292"}, "2717": {"model_id": "2717", "ARO_accession": "3004073", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "800", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "MuxA is a membrane fusion protein component of the efflux pump system MuxABC-OpmB in Pseudomonas aeruginosa.", "model_sequences": {"sequence": {"4042": {"dna_sequence": {"fmax": "2855291", "fmin": "2854010", "accession": "NC_002516.2", "strand": "-", "sequence": "TCATTCAGCGCTCCCGCTACCCACCGAGTCGCCCTGGAGGCCGCTGGGGCGGCCAGTCTGCGGTTTCTGCGGCTCGCCCTCGAGGACCTGCGGGGAGGCCTCGGCGACACGCACTTCCATACCGTCGCGCAGGCGGTCGGTGCCTTCCACCACCACCTGCTCGCCGGCCTTCAGGCCGCTTTCCACCACCACCCGCTCGTTCTCGCTGGTGCCGATGGCGACGCTGCGCTGGCTGACCTTGTTGTCGGCGCCGACCACGTAGACATAGATACCGTTGGTGCCGCGCTGCACGGCGTTGGCCGGAATGGTCAGCACGCCTTTGAGGGTCTGCGCCAGCAGGCGCACGTTGACGAACTGGTTGGGGAACAGCTTGCCGTCGGCGTTCTCGAAGCGCGCCTTGAGCTTGACCGTGCCGGTGGTGGTGTCGATCTGGTTGTCCAGGGTGGTCAGGGTGCCTTCGGCGAGAACCTTGTCCTGGTTGCGGTCCAGCGCGGTGACCGTCAGCTTGCCGGGGCCGTTCATCTGCTCGACGACGGTGCCGATCTGCTGCTGCGGCAGGCTGAACACCACCGAGATCGGCTTGACCTGGGTGATCACCACCAGCGGCGTGGTATCGCCGCTGGTGACCAGGTTGCCGATGTCCACCTGGCGCAGGCCGAGGCGCCCGGAAATCGGTGCGCGGACCTCGGTGAAGGTCAGGTTGAGGCGGGCGTCGTCGACCTGGCCCTGGTTGGTACGGATGGTGCCCTGCAACTGGCGGACCTGGGCTTCCTGGGTATCCAGGGTCTGCTTGGCTATCGAGTCCTCGGCATACAGCCCCTTGTAGCGCTGCAGGTCGATCTCGGCGTTCTTCAGTTGCGCCTGGTTCTGCATCAGCGTGCCCTCGGCCTGGGCCAGCGCCGCCTTGTAGGTGCGCGGGTCGACCACCGCCAGCAGGTCGCCGGCCTTGACCTCCTGCCCCTCCTGGAACAGCACCTTGACCAGCTCGCCGTTGACCCGCGGCTTGACGTTCACCGTGTTGAAGGCGGTGACGGTGCCAAGCGCGTTGAAATGCAGCGCCAGGTCGCCCTGCTCCACCCTGGCCACGCCGACGGTGAGCGCGTTGGCCTTGGGCAGCGCGGCGCCCGGCTTGCCGCCGCGACCGGGTCGCCCGTCGGAGGACGGTGCCGAGGCGGGCGCCGCCAGCCACATCACCAGGCCGATCACGGCGGCGAAGGCCAGGGCGGTGATCAGCCACGGGCGCAGGGTACGGAACTTGGATTTACCGGTCGTTGGAGTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_251218.1", "sequence": "MTPTTGKSKFRTLRPWLITALAFAAVIGLVMWLAAPASAPSSDGRPGRGGKPGAALPKANALTVGVARVEQGDLALHFNALGTVTAFNTVNVKPRVNGELVKVLFQEGQEVKAGDLLAVVDPRTYKAALAQAEGTLMQNQAQLKNAEIDLQRYKGLYAEDSIAKQTLDTQEAQVRQLQGTIRTNQGQVDDARLNLTFTEVRAPISGRLGLRQVDIGNLVTSGDTTPLVVITQVKPISVVFSLPQQQIGTVVEQMNGPGKLTVTALDRNQDKVLAEGTLTTLDNQIDTTTGTVKLKARFENADGKLFPNQFVNVRLLAQTLKGVLTIPANAVQRGTNGIYVYVVGADNKVSQRSVAIGTSENERVVVESGLKAGEQVVVEGTDRLRDGMEVRVAEASPQVLEGEPQKPQTGRPSGLQGDSVGSGSAE"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "MuxA", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "41155", "model_name": "MuxA", "model_type_id": "40292"}, "2743": {"model_id": "2743", "ARO_accession": "3004078", "ARO_name": "Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime", "ARO_description": "AcrR is the repressor of the AcrAB operon, where a mutation in AcrR allows AcrAB-TolC to confer resistance to ciprofloxacin, tetracycline, and ceftazidime.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7636": "2306,2661,1104,826"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41180", "model_name": "E. coli AcrAB-TolC with AcrR mutation conferring resistance to cirpofloxacin", "model_type_id": "41112"}, "2688": {"model_id": "2688", "ARO_accession": "3004056", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "100", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "ArmR, a 53-amino-acid antirepressor, allosterically inhibits MexR dimer-DNA binding by occupying a hydrophobic binding cavity within the center of the MexR dimer. ArmR up-regulation and MexR-ArmR complex formation have previously been shown to upregulate MexAB-OprM.", "model_sequences": {"sequence": {"4019": {"dna_sequence": {"fmax": "4165880", "fmin": "4165718", "accession": "NC_002516.2", "strand": "-", "sequence": "TCAGTAGAAGTGCTCGCCGTAGAGGTCCCAGGCATTGCGCCGGGCTGCCCGGCGCAGCTGCTCGGTGTAATCCCGCCGGCCGACGGCGGATCGTCCCGAGCTGGCAGCGACAGCTTCGGTCTCGGTGCGGGACGGTTTGTTGCGCGGAGTGTTCAGGGACAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_252408.1", "sequence": "MSLNTPRNKPSRTETEAVAASSGRSAVGRRDYTEQLRRAARRNAWDLYGEHFY"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36590": {"category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux."}}, "ARO_name": "ArmR", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "41121", "model_name": "ArmR", "model_type_id": "40292"}, "2689": {"model_id": "2689", "ARO_accession": "3004058", "model_param": {"snp": {"param_type": "single resistance variant", "param_value": {"7546": "C2551T", "7547": "G2576T"}, "clinical": {"7546": "C2551T", "7547": "G2576T"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Point mutations in the 23S rRNA subunit of the large ribosomal bacterial subunit in Staphylococcus aureus, which confer resistance to linezolid by disrupting antibiotic target binding", "model_sequences": {"sequence": {"4021": {"dna_sequence": {"fmax": "2926", "fmin": "0", "accession": "NZ_CP009828.1", "strand": "+", "sequence": "CTCATGATTTTATAAGGATTTATTTATTGATATTTACATAAAAATACTGTGCATAACTAATAAGCAGGATAAAGTTATCCACCGATTGTTATTAACTTGTGGATAATTATTAACATGGTGTGTTTAGAAGTTATCCACGGCTGTTATTTTTGTGTATAACTTAAAAATTTAAGAAAGATGGAGTAAATTTATGTCGGAAAAAGAAATTTGGGAAAAAGTGCTTGAAATTGCTCAAGAAAAATTATCAGCTGTAAGTTACTCAACTTTCCTAAAAGATACTGAGCTTTACACGATCAAAGATGGTGAAGCTATCGTATTATCGAGTATTCCTTTTAATGCAAATTGGTTAAATCAACAATATGCTGAAATTATCCAAGCAATCTTATTTGATGTTGTAGGCTATGAAGTAAAACCTCACTTTATTACTACTGAAGAATTAGCAAATTATAGTAATAATGAAACTGCTACTCCAAAAGAAACAACAAAACCTTCTACTGAAACAACTGAGGATAATCATGTGCTTGGTAGAGAGCAATTCAATGCCCATAACACATTTGACACTTTTGTAATCGGACCTGGTAACCGCTTTCCACATGCAGCGAGTTTAGCTGTGGCCGAAGCACCAGCCAAAGCGTACAATCCATTATTTATCTATGGAGGGGTTGGTTTAGGAAAAACCCATTTAATGCATGCCATTGGTCATCATGTTTTAGATAATAATCCAGATGCCAAAGTGATTTACACATCAAGTGAAAAATTCACAAATGAATTTATTAAATCAATTCGTGATAACGAAGGTGAAGCTTTCAGAGAAAGATATCGTAATATCGACGTCTTATTAATCGATGATATTCAGTTCATACAAAATAAAGTACAAACACAAGAAGAATTTTTCTATACTTTTAATGAATTGCATCAGAATAACAAGCAAATAGTTATTTCGAGTGATCGACCGCCAAAGGAAATTGCACAATTAGAAGATCGATTACGTTCACGCTTTGAATGGGGGCTAATTGTTGATATTACGCCACCAGATTATGAAACTCGAATGGCAATTTTGCAGAAGAAAATTGAAGAAGAAAAATTAGATATTCCACCAGAAGCTTTAAATTATATAGCAAATCAAATTCAATCTAATATTCGTGAATTAGAAGGTGCATTAACGCGTTTACTTGCATATTCACAATTATTAGGAAAACCAATTACAACTGAATTAACTGCTGAAGCTTTAAAAGATATCATTCAAGCACCAAAATCTAAAAAGATTACCATCCAAGATATTCAAAAAATTGTAGGCCAGTACTATAATGTTAGAATTGAAGATTTCAGTGCAAAAAAACGTACAAAGTCAATTGCATATCCGCGTCAAATAGCTATGTACTTGTCTAGAGAGCTTACAGATTTCTCATTACCTAAAATTGGTGAAGAATTTGGTGGGCGTGATCATACGACCGTCATTCATGCTCATGAAAAAATATCTAAAGATCTAAAAGAAGATCCTATTTTTAAACAAGAAGTAGAGAATCTTGAAAAAGAAATAAGAAATGTATAAGTAGGAAACTTTGGGAAATGCAATCTGTTATATAACAGCACTAATAATAACTATCATTTTTTACATTTCTATATGCTAATGTGGCAAGATGAGCAAAACTCATTTTGTGGATAATGTTTAAAAGTCATACACACCATACACAAGTTATCAACATGTGTATAACTTCGCCAAATCTATGTTTTTAAGACTTATCCACCAATCCACAGCACCTACTACTATTACTAAGAACTTAAAACCTATATAATTATATATAAACGACTGGAAGGAGTTTTAATTAATGATGGAATTCACTATTAAAAGAGATTATTTTATTACACAATTAAATGACACATTAAAAGCTATTTCACCAAGAACAACATTACCTATATTAACTGGTATCAAAATCGATGCGAAAGAACATGAAGTTATATTAACTGGTTCAGACTCTGAAATTTCAATAGAAATCACTATTCCTAAAACTGTAGATGGCGAAGATATTGTCAATATTTCAGAAACAGGCTCAGTAGTACTTCCTGGACGATTCTTTGTTGATATTATAAAAAAATTACCTGGTAAAGATGTTAAATTATCTACAAATGAACAATTCCAGACATTAATTACATCAGGTCATTCTGAATTTAATTTAAGTGGCTTAGATCCAGATCAATATCCTTTATTACCTCAAGTTTCTAGAGATGACGCAATTCAATTGTCGGTAAAAGTGCTTAAAAACGTGATTGCACAAACGAATTTTGCAGTGTCCACCTCAGAAACACGCCCAGTACTAACTGGTGTGAACTGGCTTATACAAGAAAATGAATTAATATGCACAGCGACTGACTCACACCGCTTGGCTGTAAGAAAGTTGCAGTTAGAAGATGTTTCTGAAAACAAAAATGTCATCATTCCAGGTAAGGCTTTAGCTGAATTAAATAAAATTATGTCTGACAATGAAGAAGACATTGATATCTTCTTTGCTTCAAACCAAGTTTTATTTAAAGTTGGAAATGTGAACTTTATTTCTCGATTATTAGAAGGACATTATCCTGATACAACACGTTTATTCCCTGAAAACTATGAAATTAAATTAAGTATAGACAATGGGGAGTTTTATCATGCGATTGATCGTGCATCTTTATTAGCACGTGAAGGTGGTAATAACGTTATCAAATTAAGTACAGGTGATGACGTTGTTGAATTATCTTCTACATCACCAGAAATTGGTACTGTAAAAGAAGAAGTTGATGCAAACGATGTTGAAGGTGGTAGCCTGAAAATTTCATTCAACTCTAAATATATGATGGATGCTTTAAAAGCAATCGATAATGATGAGGTTGAAGTTGAATTCTTCGGTACAATGAAACCATTTATTCTAAAACCAAAAGGTGACGACTC"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"GI": "", "sequence": ""}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}}, "ARO_name": "Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid", "model_type": "rRNA mutation model", "model_description": "A model to detect mutations in ribosomal RNA genes (rRNA) that confer elevated resistance to antibiotic(s) relative to wild type. These models include a reference rRNA sequence and mapped resistance variants.", "ARO_id": "41124", "model_name": "Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid", "model_type_id": "40295"}, "2685": {"model_id": "2685", "ARO_accession": "3004054", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR.", "model_sequences": {"sequence": {"4018": {"dna_sequence": {"fmax": "1885022", "fmin": "1884344", "accession": "LT673656.1", "strand": "-", "sequence": "TCAGTGGCTGTAGTAGTAGCCGCGGCCGCGCAGGGCGAGGATGCGCGGGCTGCCGTCGGGGTGGCTGCCGAGCTTCTTGCGCAGGTTGCTGACGTGCATGTCCAGGCTGCGGTCGTAGAGGGTCAGCTTGCGGCCCAGCGCCAGTTGCGCCAGGGCCTGCTTGTCCAGCGGCTCGCCGGGCTGGCGCAGGAGCGCTTCGAGGATGCGGCTTTCGGAAAGGGTCAGGCTGATCTCCTGGCCGTCGATCTGCGCCACGCCGCGCGTCAGGTTCAGCGACAGGTCGCCCAGTTGCATCTGCGCGCTGGGTTGCGCCGGGTGGGTTCGCCGCAGCACGGCGCGCAGCCGTGCGGTGAGTTCGCGCGGGTCGCAGGGCTTGGCCAGGTAGTCGTCGGCGCCCAGTTCCAGACCGAGGATGCGGTCCAGCGGCTCGCCGCGGGCGGACAGCATCAGCACCGGCAGGTCGGGATGGTCGCCGCGCAGTTGCTTGAGCAGTTCCAGGCCGCTACCGTCCGGCAGCATCACGTCGAGCACCACGGCATCCGGTGTCTGCTCGGCGAGGGCGCGACGGGCCTGGGCGCCGTCGTGGCTGGCACGCACGGAGAAACCTTCCTGGACCAGCCAGGTACCGAGCAGCTCGCAGAGCTCCCGGTCATCGTCGATCAACAGCAGTTCGCTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"GI": "SIP52035.1", "sequence": "MSELLLIDDDRELCELLGTWLVQEGFSVRASHDGAQARRALAEQTPDAVVLDVMLPDGSGLELLKQLRGDHPDLPVLMLSARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRTHPAQPSAQMQLGDLSLNLTRGVAQIDGQEISLTLSESRILEALLRQPGEPLDKQALAQLALGRKLTLYDRSLDMHVSNLRKKLGSHPDGSPRILALRGRGYYYSH"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36590": {"category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux."}}, "ARO_name": "Pseudomonas aeruginosa CpxR", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "41119", "model_name": "Pseudomonas aeruginosa CpxR", "model_type_id": "40292"}, "2686": {"model_id": "2686", "ARO_accession": "3004053", "ARO_name": "MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam", "ARO_description": "CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7534": "2685,440,1925,1305"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41118", "model_name": "MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam", "model_type_id": "41112"}, "2680": {"model_id": "2680", "ARO_accession": "3004048", "ARO_name": "MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin", "ARO_description": "MexAB-OprM efflux pump system with a prematurely terminated MexR confers resistance to meropenem and ciprofloxacin.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7529": "2678,440,1925,1305"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41113", "model_name": "MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin", "model_type_id": "41112"}, "2681": {"model_id": "2681", "ARO_accession": "3004049", "model_param": {"blastp_evalue": {"param_value": "1e-150", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}, "snp": {"param_type": "single resistance variant", "param_value": {"7530": "Y151V"}, "clinical": {"7530": "Y151V"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis.The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan.", "model_sequences": {"sequence": {"4014": {"dna_sequence": {"fmax": "1151404", "fmin": "1150669", "accession": "NC_000913.3", "strand": "+", "sequence": "ATGAATTTTGAAGGAAAAATCGCACTGGTAACCGGTGCAAGCCGCGGAATTGGCCGCGCAATTGCTGAAACGCTCGCAGCCCGTGGCGCGAAAGTTATTGGCACTGCGACCAGTGAAAATGGCGCTCAGGCGATCAGTGATTATTTAGGTGCCAACGGCAAAGGTCTGATGTTGAATGTGACCGACCCGGCATCTATCGAATCTGTTCTGGAAAAAATTCGCGCAGAATTTGGTGAAGTGGATATCCTGGTCAATAATGCCGGTATCACTCGTGATAACCTGTTAATGCGAATGAAAGATGAAGAGTGGAACGATATTATCGAAACCAACCTTTCATCTGTTTTCCGTCTGTCAAAAGCGGTAATGCGCGCTATGATGAAAAAGCGTCATGGTCGTATTATCACTATCGGTTCTGTGGTTGGTACCATGGGAAATGGCGGTCAGGCCAACTACGCTGCGGCGAAAGCGGGCTTGATCGGCTTCAGTAAATCACTGGCGCGCGAAGTTGCGTCACGCGGTATTACTGTAAACGTTGTTGCTCCGGGCTTTATTGAAACGGACATGACACGTGCGCTGAGCGATGACCAGCGTGCGGGTATCCTGGCGCAGGTTCCTGCGGGTCGCCTCGGCGGCGCACAGGAAATCGCCAACGCGGTTGCATTCCTGGCATCCGACGAAGCAGCTTACATCACGGGTGAAACTTTGCATGTGAACGGCGGGATGTACATGGTCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli str. K-12 substr. MG1655", "NCBI_taxonomy_id": "511145", "NCBI_taxonomy_cvterm_id": "36849"}, "protein_sequence": {"GI": "NP_415611.1", "sequence": "MNFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLMLNVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAVMRAMMKKRHGRIITIGSVVGTMGNGGQANYAAAKAGLIGFSKSLAREVASRGITVNVVAPGFIETDMTRALSDDQRAGILAQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHVNGGMYMV"}}}}, "ARO_category": {"35950": {"category_aro_name": "antibiotic resistant gene variant or mutant", "category_aro_cvterm_id": "35950", "category_aro_accession": "0000031", "category_aro_description": "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes."}, "40348": {"category_aro_name": "determinant of triclosan resistance", "category_aro_cvterm_id": "40348", "category_aro_accession": "3003696", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to the antibacterial biocide triclosan."}}, "ARO_name": "antibiotic resistant fabG", "model_type": "protein variant model", "model_description": "A model to detect proteins that confer elevated resistance to antibiotic(s) relative to wild type. These models include reference sequences (which may or may not be a wild type sequence), a curated BLASTP cut-off, and mapped resistance variants.", "ARO_id": "41114", "model_name": "antibiotic resistant fabG", "model_type_id": "40293"}, "2682": {"model_id": "2682", "ARO_accession": "3004051", "ARO_name": "MexAB-OprM with NalC mutations conferring resistance to aztreonam", "ARO_description": "MexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7531": "1670,440,1925,1305"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41116", "model_name": "MexAB-OprM with NalC mutations conferring resistance to aztreonam", "model_type_id": "41112"}, "2744": {"model_id": "2744", "ARO_accession": "3004079", "ARO_name": "Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline", "ARO_description": "The Escherichia coli AcrAB-TolC with MarR mutation (Y137H) conferring resistance to ciprofloxacin and tetracycline.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7637": "2661,1104,826,431"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41181", "model_name": "Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline", "model_type_id": "41112"}, "2724": {"model_id": "2724", "ARO_accession": "3004076", "ARO_name": "MuxABC-OpmB", "ARO_description": "MuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7597": "2717,2718,2720,2716"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41159", "model_name": "MuxABC-OpmB", "model_type_id": "41112"}, "2720": {"model_id": "2720", "ARO_accession": "3004075", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "2000", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "MuxC is one of the two necessary RND components of the MuxABC-OpmB efflux pumps system in Pseudomonas aeruginosa.", "model_sequences": {"sequence": {"4045": {"dna_sequence": {"fmax": "2850886", "fmin": "2847775", "accession": "NC_002516.2", "strand": "-", "sequence": "TCATAGGGGTGTCTCCAGCGCACCGTCCGTGCGTACGCCGCGTTTCTGGTTGACCCAGTGGCGCAGGCGGTCGAGATAGAGGTAGACCACCGGGGTGGTGTACAGGGTCAGCAACTGGCTGCCGATCAGCCCGCCGACGATGGTGATGCCCAGCGGCCGGCGCAGCGCGGCGTCGCCGCCGATGCCGAAGATCAGCGGCAAGGCGCCGAGCAAGGCGGCCAGGGTGGTCATCATGATCGGCCGGAAGCGCATCATGCAGGCCTCGAGGATCGCCTCGCGCGGGCTCAGGCCGTGGTTGCGCTCGGCCTCCAGGGCGAAGTCGATCATCATGATCGCGTTCTTCTTGACGATGCCGATCAGCAGGATGATGCCGATCAGCGCGATCAGGCTCAGCTCGCTGCGGCAGAGGATCAGCGCGAGCAGCGCGCCGACCCCGGCCGAAGGCAGGGTCGAGAGGATGGTCAGCGGGTGCACGTAGCTCTCGTAGAGGATGCCGAGGACGATGTACACCGCCAGCAGCGCCAGGAGGATCAGCCAGGGCATCTGGTTCTGCGTGTCCTGCACCGCGCCGGCGTTGCCCTCGAAGCTGGTCTGCACGTCCACCGGGATGTGCAGCGGCTCCAGGGCCTGCATGATGGCCTCGCGGGTCGGGCCGATCTGCGCGCCCGGTGCCAGGTTGAAGGACAGCGTGGTGGCGGCGAACTGGCCCTGGTGGTTGACCTCCAGCGGTGCCCGGCTCGGTTCGTAGTGGCTGAACGCGGACAGCGGCACGCGCTGGCCGTCGTTGCCGATCACCTGGACCTGGCGGAGGATCTCCGGGCTCTGCTGGTACTGCTGGTCGACCTCCATCACCACCCGGTACTGGTTCAGCGGGTTGAAGATGGTCGACACCTGGCGCTGGCCGAAAGAGTCGTTGAGCACCGCGTCGACCATTTCCACGTTGATCCCCAGGGTCGCCGCGCGGTCGCGGTCGATCACCAGGCGGGTCTGCACGCCCTTGTCCTGGGAGTCGCTGTTGACGTCCACCAGCTGCGGCAGCTTGCGCATCGCCGCCTCGACCTTCGGCGCCCATTCGCGGAGCAGGGTCAGGTCGTCGCTGCGCAGGGTGAATTCGTACTGCGCGTTGCTGTCGCGGCCGCCCAGGCGCACGTCCTGGCCGGCGTTGAGATAGAGCGCCGCGCCGGGCACCTTGGCGATCCGCTCGCGCAGCCGGGTGAGGACCTTCTCCACCGGGTCGCGCTCGCCGATCGGCTTGAGAGTGACGAAGAACGAACCGGTGTTGCTCGACTGCCAACGGCCGCCACCGATGAAGCCGACCACGTTTTCCACCGCCGGATCGGAAGAGAGGATCTTGCGGTACTCGCCCATCTTCGCGCTCAGGGACTGGAACGAGATGCTCTGGTCGGCCACCGCGTAGCCGCGCAGGCGCCCGGAGTCCTGCTGCGGGAGGAAGCCCTTGGGCACCACCACGAACAACCAGAGGTTCATGGCGATGCAGGCCAGCATGATCACCACCATCAGCCGCGAGTGCTCCAGCGCCCAGCCCAGGCTGGCGCGGTAGCGCAGCATGAAGGCGGCGAAGAAGCGATCGCTGCGCCGCGCCAGGGAAGCGCCTTCGGGCCGTTTCAGCGGACGCAGCAGACGCGCGCAGAGCATCGGCGTGAGGGTCAGGGATACCACCAGGGACACCAGGATCGCCGCCGAGAGAGTCACCGCGAACTCGCGGAACAGCCGTCCGGTGAGGCCACCCATGAGCAGCAGCGGGATGAACACCGCGACCAGCGAGAGCGTCATCGACAGCACGGTGAAACCGACCTGGCGGGCGCCGGTGATCGCCGCCTGGATCGGCGGATCGCCCTCCTCGATGCGTCGGGCGATGTTCTCCACCACCACTATGGCGTCATCCACCACGAAGCCGGTGGCGATGATCAGCGCCATCAGCGACAGGTTGTTCAGGCTGAAGTCGCACAGGTACATGACCGCGAAGGTGCCGATCAGCGAGACCGGCACCGCCAGGCTGGGGATCAGCGTGGCGCGGCCGTTGCGCAGGAACAGGAAGACCACCAGGATCACCAGCGCCACCGAGATCAGCAGGGTCAGCTCGGCCTCTTCCAGCGACGCACGGATCGACGGGCTGCGATCGTCCATCACGTTCAGCTTGACCTGCGGCCCGAGCAGTTCCTGCAACACCGGCAGTTGCGCGTGGATGGCGTCGGTGGCCTCGATGATGTTGGCGCCGGGCTGGCGGGTGACGATTAGCAGCACAGCCGGCAGGTCGTCGGAAAAGCCGGCGTTGCGCACGTCCTCCACCGAGTCGCTGACCTTGGCCACGTCGCCGAGGCGCACCGCGGCGCCGTTGTCGGCGTTGTAGTGGATCACCAGCGGCTCGTACTCGCGGGCCTTGCGCAACTGGTCGTTGGCGTCCACCTGCCAGTGCTTGTCGTCCTTCTCGACGGCGCCCTTGGGGCCGTTGCTGTTGGCCGCGGCGATGGCCGTGCGCACGCTGTCCAGGGACAGCCCGTACTGGCTCATGGCATCCGGGTTGAGGTCGACCCGCACCGCCGGCAGCGAGCTGCCGCCGATGCTCACCTGCCCTACCCCCTGCACCTGCGACAGCTTGGGCGCCAGCACGGTCGAGGCGAGGTCGTACATCTCGCCGCGACTCTGGGTCTCCGAGGTCAGGGTGAGGACCATGATCGGCATGTCCGAGGGGTTGGCCTTGCGGTAGCTGGGATTGTTCGGCATACCGCTGGGCAGCAGGCTCATCGCGCCGTTGATCGCCGCCTGCACCTCGCGGGCGGCGCCGTCGATGTCCTTCTCCAGGTCGAACACGAGCACCACGGTGGTCGAGCCCAGCGAACTGCTGGAGGTCATCTCGCTGATCCCGGCGATCCGTCCCAGCGAGCGCTCCAGCGGCGTGGCCACCGACGAGGCCATGGTTTCCGGGCTGGCGCCCGGCAGGCTGGCGCTGACCACGATGGCCGGAAAATCGACGTTGGGCAGCGGCGCCACCGGCAGCAGGCCGAACGACAGGGTGCCGGCCAGCAGCAACGCCAGGGTCAGCAGCGTGGTGGCGACCGGGCGGCGGATGAAGGGCGTGGACAGACTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_251216.1", "sequence": "MSLSTPFIRRPVATTLLTLALLLAGTLSFGLLPVAPLPNVDFPAIVVSASLPGASPETMASSVATPLERSLGRIAGISEMTSSSSLGSTTVVLVFDLEKDIDGAAREVQAAINGAMSLLPSGMPNNPSYRKANPSDMPIMVLTLTSETQSRGEMYDLASTVLAPKLSQVQGVGQVSIGGSSLPAVRVDLNPDAMSQYGLSLDSVRTAIAAANSNGPKGAVEKDDKHWQVDANDQLRKAREYEPLVIHYNADNGAAVRLGDVAKVSDSVEDVRNAGFSDDLPAVLLIVTRQPGANIIEATDAIHAQLPVLQELLGPQVKLNVMDDRSPSIRASLEEAELTLLISVALVILVVFLFLRNGRATLIPSLAVPVSLIGTFAVMYLCDFSLNNLSLMALIIATGFVVDDAIVVVENIARRIEEGDPPIQAAITGARQVGFTVLSMTLSLVAVFIPLLLMGGLTGRLFREFAVTLSAAILVSLVVSLTLTPMLCARLLRPLKRPEGASLARRSDRFFAAFMLRYRASLGWALEHSRLMVVIMLACIAMNLWLFVVVPKGFLPQQDSGRLRGYAVADQSISFQSLSAKMGEYRKILSSDPAVENVVGFIGGGRWQSSNTGSFFVTLKPIGERDPVEKVLTRLRERIAKVPGAALYLNAGQDVRLGGRDSNAQYEFTLRSDDLTLLREWAPKVEAAMRKLPQLVDVNSDSQDKGVQTRLVIDRDRAATLGINVEMVDAVLNDSFGQRQVSTIFNPLNQYRVVMEVDQQYQQSPEILRQVQVIGNDGQRVPLSAFSHYEPSRAPLEVNHQGQFAATTLSFNLAPGAQIGPTREAIMQALEPLHIPVDVQTSFEGNAGAVQDTQNQMPWLILLALLAVYIVLGILYESYVHPLTILSTLPSAGVGALLALILCRSELSLIALIGIILLIGIVKKNAIMMIDFALEAERNHGLSPREAILEACMMRFRPIMMTTLAALLGALPLIFGIGGDAALRRPLGITIVGGLIGSQLLTLYTTPVVYLYLDRLRHWVNQKRGVRTDGALETPL"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "ARO_name": "MuxC", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "41158", "model_name": "MuxC", "model_type_id": "40292"}, "2705": {"model_id": "2705", "ARO_accession": "3004068", "ARO_name": "MexEF-OprN with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin", "ARO_description": "The MexEF\u2013OprN efflux pump with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin. The model includes the MexT regulator, as MexS is suggested to inactivate MexT.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7584": "1041,1608,1067,1300,172"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41145", "model_name": "MexEF\u2013OprN with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin", "model_type_id": "41112"}, "2704": {"model_id": "2704", "ARO_accession": "3004066", "ARO_name": "MexEF-OprN with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin", "ARO_description": "The MexEF\u2013OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7572": "1608,1067,1300,172"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41142", "model_name": "MexEF\u2013OprN with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin", "model_type_id": "41112"}, "2707": {"model_id": "2707", "ARO_accession": "3004070", "ARO_name": "MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin", "ARO_description": "A deletion of MvaT results in the overexpression of MexEF-OprN conferring resistance to chloramphenicol and norfloxacin.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7585": "2706,1067,1300,172"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41147", "model_name": "MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin", "model_type_id": "41112"}, "2745": {"model_id": "2745", "ARO_accession": "3000384", "ARO_name": "AcrAB-TolC", "ARO_description": "AcrAB-TolC is a tripartite RND efflux system that confers resistance to tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin  in Gram-negative bacteria. The system spans the cell membrane (AcrB) and the outer-membrane (TolC), and is linked together in the periplasm by AcrA.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7639": "2661,1104,826,2306,431,1922,538,228,2066"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "36523", "model_name": "E. coli AcrAB-TolC", "model_type_id": "41112"}, "2729": {"model_id": "2729", "ARO_accession": "3003694", "ARO_name": "MexJK-OprM", "ARO_description": "MexJK-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OprM is the outer membrane factor protein.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7606": "2205,2206,2219,1305"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "40346", "model_name": "MexJK-OprM", "model_type_id": "41112"}, "2697": {"model_id": "2697", "ARO_accession": "3004063", "model_param": {"blastp_evalue": {"param_value": "1e-100", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}}, "ARO_description": "EdeQ is an N-acetyltransferase enzyme that confers high-level self-resistance to edeine in Brevibacillus brevis, a natural edeine producer. EdeQ converts active edeine to N-acetyledeine, which is ineffective in vivo.", "model_sequences": {"sequence": {"4026": {"dna_sequence": {"fmax": "45332", "fmin": "44894", "accession": "KC771276.1", "strand": "+", "sequence": "ATGTCTGTGACACTTCGTGAAGTAACTTTGGAAAACTGGGAAGAGTGTATTGAACTGGAACCTACTCCCGAACAGAGCGAGTTTGTTGCCCCAAACCTTTACTCCATCGCTGAATCAAAGTTTCAAACTACATTTGTTCCTTTGGCCATATACCATGATGACACGATGGTTGGCTTTGTCATGTATGGGCTTGACCCTGACGATGGGAATTACTGGATTTACAGACTCTTAATTGATGCGAAGTACCAACGACTAGGCTATGGACGTACTGCCATTTCACAAGTCATTGAGATCCTGAAAGCAAAGGAAGATTGTCAAAAAATTGTCATTGGCTATGCCCCAGCCAATGTCGCAGCCGAAAACCTTTACGCTTCGCTCGGATTTCAAAAGAATGGAATGGTTTTGTTCGGCGAGACGATTGCAGAATTGAACTTTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Brevibacillus brevis", "NCBI_taxonomy_id": "1393", "NCBI_taxonomy_cvterm_id": "41133"}, "protein_sequence": {"GI": "AHH86051.1", "sequence": "MSVTLREVTLENWEECIELEPTPEQSEFVAPNLYSIAESKFQTTFVPLAIYHDDTMVGFVMYGLDPDDGNYWIYRLLIDAKYQRLGYGRTAISQVIEILKAKEDCQKIVIGYAPANVAAENLYASLGFQKNGMVLFGETIAELNF"}}}}, "ARO_category": {"37131": {"category_aro_name": "determinant of resistance to peptide antibiotics", "category_aro_cvterm_id": "37131", "category_aro_accession": "3000751", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to peptide antibiotics."}, "36696": {"category_aro_name": "antibiotic inactivation enzyme", "category_aro_cvterm_id": "36696", "category_aro_accession": "3000557", "category_aro_description": "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance.  Inactivation includes chemical modification, destruction, etc."}, "36631": {"category_aro_name": "gene involved in self-resistance to antibiotic", "category_aro_cvterm_id": "36631", "category_aro_accession": "3000492", "category_aro_description": "Genes that are involved in conferring self resistance to antibiotic"}, "40134": {"category_aro_name": "determinant of resistance to polyamine antibiotics", "category_aro_cvterm_id": "40134", "category_aro_accession": "3003532", "category_aro_description": "Enzymes, other proteins or other gene products shown clinically to confer resistance to polyamine antibiotics."}}, "ARO_name": "EdeQ", "model_type": "protein homolog model", "model_description": "Models to detect proteins conferring antibiotic resistance, which include a reference protein sequence and a curated BLASTP cut-off.", "ARO_id": "41130", "model_name": "EdeQ", "model_type_id": "40292"}, "2706": {"model_id": "2706", "ARO_accession": "3004069", "model_param": {"blastp_evalue": {"param_value": "1e-50", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "200", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}}, "ARO_description": "MvaT, a global regulator of virulence genes in P. aeruginosa, has also shown to be able to repress the expression of the MexEF-OprN pump.", "model_sequences": {"sequence": {"4034": {"dna_sequence": {"fmax": "4844186", "fmin": "4843811", "accession": "NC_002516.2", "strand": "+", "sequence": "ATGTCCCTGATCAACGAATATCGCGCCACGGAAGAAGCCATCAAGGAACTTCAGGAGCGCCTGAAGTCCCTGGAACAAGACGACAAACTGAAAAAAGAACTGGAATTCGAAGAGAAGCTGCGCACGCTGATGGGCACTTACCAGAAGTCCCTGCGTGACGTGATTTCCCTGCTCGATCCGGACGCCAAGATCGGCAAGAGCACCCGCACCGCCAAGGCACCTGCCGGCAAGCGCGCGCGCAAGGTCAAGCAGTACAAGAACCCGCACACCGGCGAAGTCATCGAGACCAAGGGCGGCAACCACAAGACTTTGAAAGAGTGGAAAGCCAAGTGGGGCCCCGAGGCCGTCGAGAGCTGGGCCACCCTGCTCGGCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_253005.1", "sequence": "MSLINEYRATEEAIKELQERLKSLEQDDKLKKELEFEEKLRTLMGTYQKSLRDVISLLDPDAKIGKSTRTAKAPAGKRARKVKQYKNPHTGEVIETKGGNHKTLKEWKAKWGPEAVESWATLLG"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36590": {"category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux."}}, "ARO_name": "MvaT", "model_type": "protein knockout model", "model_description": "A model to detect cases where the absence of a protein due to large scale insertions or deletions confers elevated resistance to antibiotic(s). These models include reference sequences and a curated BLASTP cut-off.", "ARO_id": "41146", "model_name": "MvaT", "model_type_id": "40354"}, "2683": {"model_id": "2683", "ARO_accession": "3004052", "ARO_name": "MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics", "ARO_description": "MexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7532": "1213,440,1925,1305"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41117", "model_name": "MexAB-OprM with NalD mutation conferring resistance to multiple antibiotics", "model_type_id": "41112"}, "2713": {"model_id": "2713", "ARO_accession": "3003032", "ARO_name": "MexXY-OprM", "ARO_description": "MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7590": "2223,334,1786"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "39466", "model_name": "MexXY", "model_type_id": "41112"}, "2698": {"model_id": "2698", "ARO_accession": "3004065", "ARO_name": "MexCD-OprJ with NfxB mutation conferring resistance to ciprofloxacin", "ARO_description": "MexCD-OprJ efflux pump system with an Ala124Glu in NfxB was found to be ciprofloxacin resistant.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7554": "857,805,1523,704"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41134", "model_name": "MexCD-OprJ with NfxB mutation conferring resistance to ciprofloxacin", "model_type_id": "41112"}, "2679": {"model_id": "2679", "ARO_accession": "3004080", "ARO_name": "MexAB-OprM with MexR mutations confers resistance to multiple antibiotics", "ARO_description": "MexAB-OprM efflux pump system with MexR mutations confers resistance to multiple antibiotics in P. aeruginosa.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7528": "1474,440,1925,1305"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41182", "model_name": "MexAB-OprM with MexR mutations conferring resistance to multiple antibiotics", "model_type_id": "41112"}, "2695": {"model_id": "2695", "ARO_accession": "3004062", "ARO_name": "MexCD-OprJ with type B NfxB mutation", "ARO_description": "MexCD-OprJ with Type B NfxB mutions are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7552": "2693,805,1523,704"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41129", "model_name": "MexCD\u2013OprJ with type B NfxB mutation", "model_type_id": "41112"}, "2694": {"model_id": "2694", "ARO_accession": "3004061", "ARO_name": "MexCD-OprJ with type A NfxB mutation", "ARO_description": "MexCD\u2013OprJ with type A NfxB phenotype are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1.", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}}, "model_param": {"41141": {"param_value": {"7551": "2691,805,1523,704"}, "param_type_id": "41141", "param_type": "efflux pump components", "param_description": "This parameter describes efflux pump components (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305."}}, "model_type": "efflux pump system model", "model_description": "This meta-model type represents an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)", "ARO_id": "41128", "model_name": "MexCD\u2013OprJ with type A NfxB phenotype", "model_type_id": "41112"}, "2693": {"model_id": "2693", "ARO_accession": "3004060", "model_param": {"blastp_evalue": {"param_value": "1e-90", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "310", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}, "snp": {"param_type": "single resistance variant", "param_value": {"7549": "H87R"}, "clinical": {"7549": "H87R"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Type B NfxB mutants are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. The mutation at the 46th amino acid position is sufficient for overproduction of OprJ and the multidrug resistance.", "model_sequences": {"sequence": {"4023": {"dna_sequence": {"fmax": "5156124", "fmin": "5155560", "accession": "NC_002516.2", "strand": "+", "sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCGCGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCACCGCGAGCTGCTGGTATTCCTGGTATTCCAGTACCGCCCGGACTTCCTCGACCCGCACGGCGAAGGCGCACGCTGGCAGTCCTACCTGGAAGCGCTGGACGCCTTCTTCCTGCGCGGACAGCAGAAAGGCGTGTTTCGCATCGACATCACGGCGGCCGTGTTCACCGAACTGTTCATCACCCTGGTCTACGGCATGGTCGATGCGGAACGTCGCGGACGGGCGGCCAGCTCCAATTCCGCGCATACCCTGGAGCAGATGTTCCTCCATGGCGCCTCCAATCCGGCTCGCTCCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_253290.1", "sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36590": {"category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux."}}, "ARO_name": "Type B NfxB", "model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "ARO_id": "41127", "model_name": "Type B NfxB", "model_type_id": "41091"}, "2691": {"model_id": "2691", "ARO_accession": "3004059", "model_param": {"blastp_evalue": {"param_value": "1e-90", "param_type_id": "36302", "param_type": "BLASTP e-value", "param_description": "A curated expectation value (e-value) for assignment of an Antibiotic Resistance Ontology term based on a BLASTP hit to a CARD reference sequence."}, "blastp_bit_score": {"param_value": "310", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix."}, "snp": {"param_type": "single resistance variant", "param_value": {"7548": "R42G"}, "clinical": {"7548": "R42G"}, "param_type_id": "36301", "param_description": "A mutation or sequence variant that confers elevated resistance to antibiotic(s) relative to wild type. The most common encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. Single or multiple amino acid substitutions can be present in a single gene or across multiple genes to confer resistance to antibiotic(s). In addition, there are insertions and deletions within genome sequences that confer elevated resistance towards antibiotic(s)."}}, "ARO_description": "Type A NfxB mutants are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1.", "model_sequences": {"sequence": {"4022": {"dna_sequence": {"fmax": "5156124", "fmin": "5155560", "accession": "NC_002516.2", "strand": "+", "sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCGCGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCACCGCGAGCTGCTGGTATTCCTGGTATTCCAGTACCGCCCGGACTTCCTCGACCCGCACGGCGAAGGCGCACGCTGGCAGTCCTACCTGGAAGCGCTGGACGCCTTCTTCCTGCGCGGACAGCAGAAAGGCGTGTTTCGCATCGACATCACGGCGGCCGTGTTCACCGAACTGTTCATCACCCTGGTCTACGGCATGGTCGATGCGGAACGTCGCGGACGGGCGGCCAGCTCCAATTCCGCGCATACCCTGGAGCAGATGTTCCTCCATGGCGCCTCCAATCCGGCTCGCTCCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa PAO1", "NCBI_taxonomy_id": "208964", "NCBI_taxonomy_cvterm_id": "36804"}, "protein_sequence": {"GI": "NP_253290.1", "sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36590": {"category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux."}}, "ARO_name": "Type A NfxB", "model_type": "presence and absence of protein variant model", "model_description": "This model detects the presence and absence of mutations in protein space. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump subunit has a mutation, it can cause the drug resistance profile of the efflux pump to change. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. Thus, the goal is to be able to detect the presence and absence of mutations in efflux pump subunits and regulators to identify a functional efflux pump system, as well as, a mutated and functional efflux pump system.", "ARO_id": "41125", "model_name": "Type A NfxB", "model_type_id": "41091"}}}