Model_id Action ARO_name ARO_category Changes To Summary 344 UPDATE SHV-188 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 345 UPDATE bcrA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 346 UPDATE QnrB23 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 347 UPDATE SFH-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 340 UPDATE CMY-51 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 341 UPDATE IMP-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 342 UPDATE smeS efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 343 UPDATE OXA-31 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 348 UPDATE OXY-3-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 349 UPDATE vanL determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2317 UPDATE mgrB efflux pump complex or subunit conferring antibiotic resistance; determinant of polymyxin resistance; gene conferring resistance via absence; protein(s) and two-component regulatory system modulating antibiotic efflux; gene altering cell wall charge; model_description; model_param "UPDATED model_description with An AMR detection model for instances where the absence of a protein - due to large-scale insertion elements, large deletions, or other methods of protein knockout - confers clinical resistance to a known antibiotic. These models include reference sequences. Protein knockout models are currently in development. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2310 UPDATE Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin gene involved in self-resistance to antibiotic; antibiotic resistant gene variant or mutant; determinant of elfamycin resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 298 UPDATE vanYG1 determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 299 UPDATE CepS beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 296 UPDATE VIM-23 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 297 UPDATE CMY-98 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 294 UPDATE CfxA4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 295 UPDATE OXA-145 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 292 UPDATE TEM-17 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 293 UPDATE SHV-180 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 290 UPDATE vatD antibiotic inactivation enzyme; determinant of streptogramin resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 291 UPDATE APH(3')-Ia antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 270 UPDATE LEN-20 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 271 UPDATE CMY-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 272 UPDATE QnrB36 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 273 UPDATE VEB-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 274 UPDATE OXA-174 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 275 UPDATE OKP-B-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 276 UPDATE tetR efflux pump complex or subunit conferring antibiotic resistance; antibiotic resistant gene variant or mutant; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param; model_type_id "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue UPDATED model_type_id with 41091 " 277 UPDATE TEM-91 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 278 UPDATE imiS antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 279 UPDATE CTX-M-107 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 642 UPDATE aadA25 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2262 UPDATE mefC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2260 UPDATE vatF antibiotic inactivation enzyme; determinant of streptogramin resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2261 UPDATE lnuE determinant of lincosamide resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2267 UPDATE Escherichia coli nfsA mutations conferring resistance to nitrofurantoin determinant of nitrofuratoin resistance; antibiotic resistant gene variant or mutant; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2264 UPDATE oleC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2265 UPDATE salA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1781 UPDATE AAC(2')-Ia antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2445 UPDATE Erm(44) antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 108 UPDATE PDC-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 109 UPDATE ErmE antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 102 UPDATE TLA-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 103 UPDATE SHV-12 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 100 UPDATE Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide determinant of ethionamide resistance; antibiotic resistant gene variant or mutant; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 101 UPDATE TEM-109 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 106 UPDATE catB9 determinant of phenicol resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 107 UPDATE TEM-43 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 104 UPDATE OXA-61 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 105 UPDATE CARB-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2046 UPDATE tet(33) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2047 UPDATE OXA-322 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2044 UPDATE QnrB31 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2045 UPDATE OXY-2-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2042 UPDATE IND-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2043 UPDATE aadA8 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2040 UPDATE TEM-60 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2041 UPDATE OXA-424 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2048 UPDATE OXA-57 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2049 UPDATE QnrB72 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1213 UPDATE nalD efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1210 UPDATE novA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2688 UPDATE ArmR efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2689 UPDATE Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid antibiotic resistant gene variant or mutant; model_description; model_sequences; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED fmax with 500039 UPDATED strand with + UPDATED accession with NZ_CP009828.1 UPDATED fmin with 497113 UPDATED sequence with AGATTAAGTTATTAAGGGCGCACGGTGGATGCCTTGGCACTAGAAGCCGATGAAGGACGTTACTAACGACGATATGCTTTGGGGAGCTGTAAGTAAGCTTTGATCCAGAGATTTCCGAATGGGGAAACCCAGCATGAGTTATGTCATGTTATCGATATGTGAATACATAGCATATCAGAAGGCACACCCGGAGAACTGAAACATCTTAGTACCCGGAGGAAGAGAAAGAAAATTCGATTCCCTTAGTAGCGGCGAGCGAAACGGGAAGAGCCCAAACCAACAAGCTTGCTTGTTGGGGTTGTAGGACACTCTATACGGAGTTACAAAGGACGACATTAGACGAATCATCTGGAAAGATGAATCAAAGAAGGTAATAATCCTGTAGTCGAAAATGTTGTCTCTCTTGAGTGGATCCTGAGTACGACGGAGCACGTGAAATTCCGTCGGAATCTGGGAGGACCATCTCCTAAGGCTAAATACTCTCTAGTGACCGATAGTGAACCAGTACCGTGAGGGAAAGGTGAAAAGCACCCCGGAAGGGGAGTGAAATAGAACCTGAAACCGTGTGCTTACAAGTAGTCAGAGCCCGTTAATGGGTGATGGCGTGCCTTTTGTAGAATGAACCGGCGAGTTACGATTTGATGCAAGGTTAAGCAGTAAATGTGGAGCCGTAGCGAAAGCGAGTCTGAATAGGGCGTTTAGTATTTGGTCGTAGACCCGAAACCAGGTGATCTACCCTTGGTCAGGTTGAAGTTCAGGTAACACTGAATGGAGGACCGAACCGACTTACGTTGAAAAGTGAGCGGATGAACTGAGGGTAGCGGAGAAATTCCAATCGAACCTGGAGATAGCTGGTTCTCTCCGAAATAGCTTTAGGGCTAGCCTCAAGTGATGATTATTGGAGGTAGAGCACTGTTTGGACGAGGGGCCCCTCTCGGGTTACCGAATTCAGACAAACTCCGAATGCCAATTAATTTAACTTGGGAGTCAGAACATGGGTGATAAGGTCCGTGTTCGAAAGGGAAACAGCCCAGACCACCAGCTAAGGTCCCAAAATATATGTTAAGTGGAAAAGGATGTGGCGTTGCCCAGACAACTAGGATGTTGGCTTAGAAGCAGCCATCATTTAAAGAGTGCGTAATAGCTCACTAGTCGAGTGACACTGCGCCGAAAATGTACCGGGGCTAAACATATTACCGAAGCTGTGGATTGTCCTTTGGACAATGGTAGGAGAGCGTTCTAAGGGCGTTGAAGCATGATCGTAAGGACATGTGGAGCGCTTAGAAGTGAGAATGCCGGTGTGAGTAGCGAAAGACGGGTGAGAATCCCGTCCACCGATTGACTAAGGTTTCCAGAGGAAGGCTCGTCCGCTCTGGGTTAGTCGGGTCCTAAGCTGAGGCCGACAGGCGTAGGCGATGGATAACAGGTTGATATTCCTGTACCACCTATAATCGTTTTAATCGATGGGGGGACGCAGTAGGATAGGCGAAGCGTGCGATTGGATTGCACGTCTAAGCAGTAAGGCTGAGTATTAGGCAAATCCGGTACTCGTTAAGGCTGAGCTGTGATGGGGAGAAGACATTGTGTCTTCGAGTCGTTGATTTCACACTGCCGAGAAAAGCCTCTAGATAGAAAATAGGTGCCCGTACCGCAAACCGACACAGGTAGTCAAGATGAGAATTCTAAGGTGAGCGAGCGAACTCTCGTTAAGGAACTCGGCAAAATGACCCCGTAACTTCGGGAGAAGGGGTGCTCTTTAGGGTTAACGCCCAGAAGAGCCGCAGTGAATAGGCCCAAGCGACTGTTTATCAAAAACACAGGTCTCTGCTAAACCGTAAGGTGATGTATAGGGGCTGACGCCTGCCCGGTGCTGGAAGGTTAAGAGGAGTGGTTAGCTTCTGCGAAGCTACGAATCGAAGCCCCAGTAAACGGCGGCCGTAACTATAACGGTCCTAAGGTAGCGAAATTCCTTGTCGGGTAAGTTCCGACCCGCACGAAAGGCGTAACGATTTGGGCACTGTCTCAACGAGAGACTCGGTGAAATCATAGTACCTGTGAAGATGCAGGTTACCCGCGACAGGACGGAAAGACCCCGTGGAGCTTTACTGTAGCCTGATATTGAAATTCGGCACAGCTTGTACAGGATAGGTAGGAGCCTTTGAAACGTGAGCGCTAGCTTACGTGGAGGCGCTGGTGGGATACTACCCTAGCTGTGTTGGCTTTCTAACCCGCACCACTTATCGTGGTGGGAGACAGTGTCAGGCGGGCAGTTTGACTGGGGCGGTCGCCTCCTAAAAGGTAACGGAGGCGCTCAAAGGTTCCCTCAGAATGGTTGGAAATCATTCATAGAGTGTAAAGGCATAAGGGAGCTTGACTGCGAGACCTACAAGTCGAGCAGGGTCGAAAGACGGACTTAGTGATCCGGTGGTTCCGCATGGAAGGGCCATCGCTCAACGGATAAAAGCTACCCCGGGGATAACAGGCTTATCTCCCCCAAGAGTTCACATCGACGGGGAGGTTTGGCACCTCGATGTCGGCTCATCGCATCCTGGGGCTGTAGTCGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGTACGCGAGCTGGGTTCAGAACGTCGTGAGACAGTTCGGTCCCTATCCGTCGTGGGCGTAGGAAATTTGAGAGGAGCTGTCCTTAGTACGAGAGGACCGGGATGGACATACCTCTGGTGTACCAGTTGTCGTGCCAACGGCATAGCTGGGTAGCTATGTGTGGACGGGATAAGTGCTGAAAGCATCTAAGCATGAAGCCCCCCTCAAGATGAGATTTCCCAACTTCGGTTATAAGATCCCTCAAAGATGATGAGGTTAATAGGTTCGAGGTGGAAGCATGGTGACATGTGGAGCTGACGAATACTAATCGATCGAAGACTTAATCAAAA UPDATED NCBI_taxonomy_name with Staphylococcus aureus UPDATED NCBI_taxonomy_id with 1280 UPDATED NCBI_taxonomy_cvterm_id with 35508 UPDATED accession with UPDATED sequence with UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 5000 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2685 UPDATE Pseudomonas aeruginosa CpxR efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2686 UPDATE MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2680 UPDATE MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2681 UPDATE antibiotic resistant fabG antibiotic resistant gene variant or mutant; determinant of triclosan resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2682 UPDATE MexAB-OprM with NalC mutations conferring resistance to aztreonam efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2683 UPDATE MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 645 UPDATE mecR1 antibiotic resistance gene cluster, cassette, or operon; antibiotic target replacement protein; determinant of beta-lactam resistance; gene modulating beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 99 UPDATE QnrB38 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 98 UPDATE CMY-48 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 91 UPDATE gadX efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 90 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to rifampicin determinant of rifamycin resistance; antibiotic resistant gene variant or mutant; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 93 UPDATE SHV-105 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 92 UPDATE CTX-M-42 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 95 UPDATE CMY-56 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 94 UPDATE CMY-79 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 97 UPDATE vanXYC determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 96 UPDATE OXA-426 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1991 UPDATE otrC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1990 UPDATE CMY-82 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1993 UPDATE QnrB74 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1620 UPDATE CTX-M-156 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1627 UPDATE CTX-M-95 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1994 UPDATE gimA antibiotic inactivation enzyme; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1625 UPDATE OXA-179 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1996 UPDATE vanXM determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1999 UPDATE TEM-215 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1998 UPDATE CTX-M-83 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1628 UPDATE SHV-154 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 559 UPDATE vanXYE determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 558 UPDATE qacB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 555 UPDATE OXA-133 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 554 UPDATE OXA-163 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 557 UPDATE SHV-9 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 556 UPDATE vanYB determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 551 UPDATE CTX-M-117 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 550 UPDATE CMY-71 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 553 UPDATE VIM-35 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 552 UPDATE QnrB28 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1199 UPDATE SHV-168 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1198 UPDATE mefB efflux pump complex or subunit conferring antibiotic resistance; ARO_description; model_description; model_param; ARO_name "UPDATED ARO_description with mef(B) is a macrolide efflux gene located in the vicinity of sul3 in Escherichia coli. There is also a mefB found in Streptococcus agalactiae that confers resistance to macrolides. UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue UPDATED ARO_name with mef(B) " 1191 UPDATE mdtM efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1190 UPDATE OXA-354 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1193 UPDATE ErmH antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1192 UPDATE VEB-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1195 UPDATE SHV-55 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1194 UPDATE OXA-16 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1197 UPDATE Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1196 UPDATE OXA-71 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1759 UPDATE vanF determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1758 UPDATE OXA-326 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1757 UPDATE emrA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1756 UPDATE CMY-93 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1755 UPDATE CTX-M-23 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1754 UPDATE vanO determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1753 UPDATE SHV-148 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1752 UPDATE MdtK efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1751 UPDATE Erm(33) antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1750 UPDATE OXA-254 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1177 UPDATE KPC-12 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1176 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid antibiotic resistant gene variant or mutant; determinant of isoniazid resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a STOP codon. Nonsense SNPs truncate protein translation prematurely, resulting in a defective or completely inactive protein. In CARD, nonsense SNPs may be attached to models, and are recorded in the format: [wild type amino acid][position][STOP] (e.g. Q42STOP). This parameter is not currently used in detection algorithms. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. UPDATED param_description with A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms. DELETED blastp_evalue " 1175 UPDATE Enterococcus faecium cls conferring resistance to daptomycin antibiotic resistant gene variant or mutant; determinant of resistance to lipopeptide antibiotics; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1174 UPDATE QnrB22 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1173 UPDATE TEM-54 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1172 UPDATE OXA-194 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1171 UPDATE tet44 antibiotic target protection protein; determinant of tetracycline resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1170 UPDATE CMY-46 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1179 UPDATE IMP-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1178 UPDATE CMY-81 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 511 UPDATE dfrA3 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 510 UPDATE CTX-M-9 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1005 UPDATE Escherichia coli soxR with mutation conferring antibiotic resistance efflux pump complex or subunit conferring antibiotic resistance; antibiotic resistant gene variant or mutant; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param; model_type_id "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. UPDATED param_description with A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms. DELETED blastp_evalue UPDATED model_type_id with 41091 " 1285 UPDATE SAT-1 determinant of resistance to nucleoside antibiotics; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1284 UPDATE IND-15 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1287 UPDATE CTX-M-110 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 512 UPDATE CTX-M-82 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1281 UPDATE OXA-110 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1280 UPDATE QnrB12 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1283 UPDATE KPC-6 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1282 UPDATE SIM-1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1003 UPDATE OXA-18 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 879 UPDATE TEM-185 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1289 UPDATE OKP-B-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1288 UPDATE OXA-82 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 514 UPDATE LEN-10 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1579 UPDATE QnrB9 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1578 UPDATE SHV-123 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 689 UPDATE CTX-M-123 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 688 UPDATE MOX-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 685 UPDATE OXA-239 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 684 UPDATE SHV-37 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 687 UPDATE APH(3')-Vc antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 686 UPDATE OXA-162 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 681 UPDATE TEM-120 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 680 UPDATE CMY-54 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 683 UPDATE CMY-75 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 682 UPDATE QnrS4 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 623 UPDATE OXA-68 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1226 UPDATE adeG efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 621 UPDATE ErmF antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1224 UPDATE Erm(30) antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 627 UPDATE Escherichia coli rpoB mutants conferring resistance to rifampicin determinant of rifamycin resistance; antibiotic resistant gene variant or mutant; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1222 UPDATE FosA antibiotic inactivation enzyme; determinant of fosfomycin resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1221 UPDATE OXA-231 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1243 UPDATE mphA antibiotic inactivation enzyme; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1220 UPDATE OCH-5 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2035 UPDATE CTX-M-15 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 407 UPDATE OXA-352 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1370 UPDATE AAC(6')-Ib10 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 405 UPDATE OXA-202 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1372 UPDATE ANT(2'')-Ia antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1375 UPDATE CMY-11 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1374 UPDATE blaI antibiotic resistance gene cluster, cassette, or operon; determinant of beta-lactam resistance; gene modulating beta-lactam resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1377 UPDATE CTX-M-60 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 400 UPDATE PDC-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1379 UPDATE OXA-313 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1378 UPDATE AAC(3)-IIc antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 452 UPDATE QnrVC4 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 409 UPDATE vanRL determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 408 UPDATE OXA-380 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1343 UPDATE OXA-166 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2031 UPDATE OXA-173 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1344 UPDATE MexH efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2030 UPDATE AAC(3)-IXa antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 455 UPDATE vanC determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 9 UPDATE ACT-35 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 456 UPDATE adeR efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 457 UPDATE OXA-93 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 379 UPDATE OXA-148 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 378 UPDATE TEM-214 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 647 UPDATE TEM-89 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 371 UPDATE SHV-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 370 UPDATE SHV-112 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 373 UPDATE MIR-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 372 UPDATE qacA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 375 UPDATE mdtH efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 374 UPDATE SHV-21 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 377 UPDATE mepA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 376 UPDATE lnuC determinant of lincosamide resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1244 UPDATE OXY-5-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 393 UPDATE QnrS5 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 392 UPDATE TUS-1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 391 UPDATE VIM-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 390 UPDATE vanSG determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 397 UPDATE OXA-357 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 396 UPDATE sul3 antibiotic target replacement protein; determinant of sulfonamide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 395 UPDATE TLE beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 394 UPDATE OXA-130 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 399 UPDATE MIR-16 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 398 UPDATE TEM-71 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2306 UPDATE Escherichia coli acrR with mutation conferring multidrug antibiotic resistance efflux pump complex or subunit conferring antibiotic resistance; antibiotic resistant gene variant or mutant; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1246 UPDATE AAC(2')-Ic antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 244 UPDATE SHV-164 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 247 UPDATE TEM-158 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 246 UPDATE CTX-M-126 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 241 UPDATE ACT-30 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 240 UPDATE vanRF determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 243 UPDATE OXA-9 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 242 UPDATE SHV-152 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 249 UPDATE basS determinant of polymyxin resistance; gene altering cell wall charge; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 248 UPDATE OKP-B-9 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2274 UPDATE RlmA(II) antibiotic target modifying enzyme; gene involved in self-resistance to antibiotic; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2277 UPDATE Bacillus Cluster B intrinsic mph determinant of macrolide resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2404 UPDATE Neisseria gonorrhoeae gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2279 UPDATE Listeria monocytogenes mprF antibiotic target modifying enzyme; determinant of resistance to peptide antibiotics; gene altering cell wall charge; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with gene altering cell wall charge UPDATED category_aro_cvterm_id with 40190 UPDATED category_aro_accession with 3003580 UPDATED category_aro_description with Genes involved in alteration of the cell wall overall charge, leading to antimicrobial resistance due to reduced binding UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2278 UPDATE Bifidobacteria intrinsic ileS conferring resistance to mupirocin determinant of mupirocin resistance; antibiotic resistant gene variant or mutant; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 179 UPDATE QnrA5 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 178 UPDATE vanHA determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 177 UPDATE IMP-51 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 176 UPDATE CMY-25 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 175 UPDATE CTX-M-24 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 174 UPDATE CfxA2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 173 UPDATE arr-4 determinant of rifamycin resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 172 UPDATE OprN efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 171 UPDATE TEM-78 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 170 UPDATE IMP-19 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2051 UPDATE dfrA15 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2050 UPDATE OXA-331 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2053 UPDATE dfrA7 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2052 UPDATE APH(3'')-Ic antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2055 UPDATE LRA-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2054 UPDATE msrC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2057 UPDATE SHV-179 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2056 UPDATE mdtO efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2059 UPDATE OKP-A-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2058 UPDATE pp-flo efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 654 UPDATE dfrA26 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 655 UPDATE OXA-243 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 652 UPDATE tcr3 efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 653 UPDATE AAC(3)-VIIa antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1367 UPDATE oleD antibiotic inactivation enzyme; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 650 UPDATE aadA antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2157 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2700 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 1364 UPDATE CMY-101 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1977 UPDATE AAC(6')-Ik antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2698 UPDATE MexCD-OprJ with NfxB mutation conferring resistance to ciprofloxacin efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2697 UPDATE EdeQ determinant of resistance to peptide antibiotics; antibiotic inactivation enzyme; gene involved in self-resistance to antibiotic; determinant of resistance to polyamine antibiotics; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2695 UPDATE MexCD-OprJ with type B NfxB mutation efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2694 UPDATE MexCD-OprJ with type A NfxB mutation efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2693 UPDATE Type B NfxB efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1975 UPDATE blt efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2691 UPDATE Type A NfxB efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1365 UPDATE AAC(6')-I30 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1974 UPDATE emrD efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1973 UPDATE TEM-111 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1972 UPDATE OXA-149 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1971 UPDATE dfrB2 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1970 UPDATE SHV-44 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1362 UPDATE IMP-31 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1968 UPDATE SHV-189 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1969 UPDATE tet(35) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1618 UPDATE OXA-362 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1619 UPDATE L1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1616 UPDATE CTX-M-152 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1617 UPDATE vanE determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1614 UPDATE TEM-194 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1615 UPDATE APH(2'')-IIa antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1960 UPDATE smeB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1613 UPDATE CMY-38 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1610 UPDATE OXA-74 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1611 UPDATE SME-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1363 UPDATE CARB-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1768 UPDATE CTX-M-144 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1769 UPDATE CTX-M-115 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1361 UPDATE OXA-223 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1762 UPDATE aadA16 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1763 UPDATE NDM-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1760 UPDATE QnrB35 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1761 UPDATE OXA-351 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1766 UPDATE VIM-14 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1767 UPDATE OKP-A-16 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1764 UPDATE OXA-97 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1765 UPDATE OXA-56 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1142 UPDATE dfrA17 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1143 UPDATE OXA-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1140 UPDATE CMY-86 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1141 UPDATE OXA-169 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1146 UPDATE TEM-156 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1147 UPDATE CMY-63 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1144 UPDATE VgbB antibiotic inactivation enzyme; determinant of streptogramin resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1145 UPDATE CTX-M-124 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1148 UPDATE OXA-363 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1149 UPDATE AER-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 769 UPDATE KPC-11 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 692 UPDATE TEM-159 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 693 UPDATE OXA-22 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1544 UPDATE dfrE antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 691 UPDATE vanRE determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 696 UPDATE cfrA determinant of linezolid resistance; determinant of lincosamide resistance; determinant of macrolide resistance; antibiotic target modifying enzyme; determinant of phenicol resistance; determinant of streptogramin resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 697 UPDATE Erm(42) antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 694 UPDATE CTX-M-40 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 695 UPDATE CMY-66 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 698 UPDATE TEM-205 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 699 UPDATE QnrS9 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1548 UPDATE APH(3')-Vb antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1549 UPDATE ErmB antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 542 UPDATE adeH efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 543 UPDATE TEM-106 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 540 UPDATE emrY efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 541 UPDATE TEM-133 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 546 UPDATE TLA-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 547 UPDATE arr-5 determinant of rifamycin resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 544 UPDATE AAC(6')-Is antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 545 UPDATE GES-22 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 548 UPDATE QnrB3 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 549 UPDATE TEM-107 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 760 UPDATE TEM-6 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 761 UPDATE GES-13 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 766 UPDATE SHV-102 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 767 UPDATE OXA-207 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 764 UPDATE FOX-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 765 UPDATE QnrB7 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 414 UPDATE OXA-377 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 415 UPDATE TEM-33 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 416 UPDATE OXA-204 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 417 UPDATE QnrB6 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 410 UPDATE AAC(3)-IIIb antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 411 UPDATE QnrB11 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 412 UPDATE OXA-117 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 413 UPDATE OXA-144 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1384 UPDATE OXA-382 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1385 UPDATE mdsB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1386 UPDATE ANT(9)-Ia antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1387 UPDATE OXA-99 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1380 UPDATE TEM-193 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 419 UPDATE SLB-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1382 UPDATE rmtG antibiotic target modifying enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1383 UPDATE IMI-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 368 UPDATE CARB-14 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 369 UPDATE SHV-15 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 366 UPDATE Mycobacterium tuberculosis iniA mutant conferring resistance to Ethambutol efflux pump complex or subunit conferring antibiotic resistance; antibiotic resistant gene variant or mutant; determinant of resistance to polyamine antibiotics; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 367 UPDATE CTX-M-25 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 364 UPDATE CMY-83 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 365 UPDATE TEM-122 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 362 UPDATE CTX-M-151 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 363 UPDATE TEM-155 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 360 UPDATE AAC(6')-Iy antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 361 UPDATE OXA-278 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 380 UPDATE CTX-M-147 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 381 UPDATE QnrS1 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 382 UPDATE QnrB61 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 383 UPDATE Pseudomonas mutant PhoQ conferring resistance to colistin efflux pump complex or subunit conferring antibiotic resistance; determinant of polymyxin resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; gene altering cell wall charge; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 384 UPDATE APH(2'')-IVa antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 385 UPDATE OXA-46 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 386 UPDATE LEN-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 387 UPDATE mdtA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 388 UPDATE QnrB71 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 389 UPDATE tetW antibiotic target protection protein; determinant of tetracycline resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1253 UPDATE GES-23 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1077 UPDATE OXA-420 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2191 UPDATE AAC(6')-Iaj antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 258 UPDATE OXA-208 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2193 UPDATE TriB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2194 UPDATE TriC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2195 UPDATE OpmH efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2196 UPDATE Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. UPDATED param_description with A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms. DELETED blastp_evalue " 2198 UPDATE Pseudomonas aeruginosa parE conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 253 UPDATE vanXYG determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 251 UPDATE APH(3')-VIIa antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 256 UPDATE CMY-21 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 257 UPDATE ACT-37 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 254 UPDATE OXA-150 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 255 UPDATE determinant of bleomycin resistance determinant of resistance to glycopeptide antibiotics; gene involved in antibiotic sequestration; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2200 UPDATE APH(3')-VI antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2201 UPDATE PvrR determinant of aminoglycoside resistance; gene conferring resistance via absence; model_description; model_param "UPDATED model_description with An AMR detection model for instances where the absence of a protein - due to large-scale insertion elements, large deletions, or other methods of protein knockout - confers clinical resistance to a known antibiotic. These models include reference sequences. Protein knockout models are currently in development. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2202 UPDATE AAC(3)-Ib/AAC(6')-Ib'' antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_type; model_description "UPDATED model_type with protein domain meta-model UPDATED model_description with A meta-model used to detect specific domains of proteins that confer resistance to antibiotic(s) relative to wild type. These models include reference sequences, a curated BLASTP cut-off for each of the genes, and directionality of the fused genes (if known). " 2203 UPDATE MCR-1 determinant of polymyxin resistance; gene altering cell wall charge; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2204 UPDATE AAC(6')-IId antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2205 UPDATE MexJ efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2206 UPDATE MexK efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2207 UPDATE MexV efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2208 UPDATE MexW efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2428 UPDATE farA efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2429 UPDATE farB efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2421 UPDATE efrA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2422 UPDATE efrB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2423 UPDATE msbA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2424 UPDATE YojI efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1849 UPDATE Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides antibiotic target modifying enzyme; antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a STOP codon. Nonsense SNPs truncate protein translation prematurely, resulting in a defective or completely inactive protein. In CARD, nonsense SNPs may be attached to models, and are recorded in the format: [wild type amino acid][position][STOP] (e.g. Q42STOP). This parameter is not currently used in detection algorithms. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2426 UPDATE efmA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2427 UPDATE efpA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2432 UPDATE Klebsiella OmpK35 conferring resistance to beta-lactam gene conferring resistance via absence; protein modulating permeability to antibiotic; ARO_description; model_description; model_param; ARO_name; model_name "UPDATED ARO_description with Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK35 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. UPDATED model_description with An AMR detection model for instances where the absence of a protein - due to large-scale insertion elements, large deletions, or other methods of protein knockout - confers clinical resistance to a known antibiotic. These models include reference sequences. Protein knockout models are currently in development. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue UPDATED ARO_name with Klebsiella pneumoniae OmpK35 UPDATED model_name with Klebsiella pneumoniae OmpK35 " 1848 UPDATE CTX-M-75 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 168 UPDATE VIM-17 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 169 UPDATE IMP-33 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 164 UPDATE vanN determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 165 UPDATE VIM-29 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 166 UPDATE TEM-77 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 167 UPDATE CMY-39 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 160 UPDATE OXA-236 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 161 UPDATE SHV-56 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 162 UPDATE KPC-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 163 UPDATE OXA-376 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2518 UPDATE tetB(48) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2519 UPDATE LlmA 23S ribosomal RNA methyltransferase antibiotic target modifying enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2517 UPDATE tetA(48) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 908 UPDATE CTX-M-139 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2734 UPDATE PmpM efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 909 UPDATE OXA-5 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2731 UPDATE MexJK-OpmH efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2732 UPDATE MexVW-OprM efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2733 UPDATE TriABC-OpmH efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 1090 UPDATE TEM-169 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1091 UPDATE IMP-6 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1814 UPDATE AAC(6')-Ie-APH(2'')-Ia antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1815 UPDATE CTX-M-134 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1816 UPDATE TEM-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1817 UPDATE vgaB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1810 UPDATE VIM-15 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1811 UPDATE CARB-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1812 UPDATE KHM-1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1813 UPDATE MOX-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1818 UPDATE GES-26 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1819 UPDATE TEM-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1098 UPDATE vanB determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1099 UPDATE OXA-48 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1609 UPDATE QnrC antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1608 UPDATE MexT efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1979 UPDATE FosA4 antibiotic inactivation enzyme; determinant of fosfomycin resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1978 UPDATE OXA-200 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1601 UPDATE LRA-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1976 UPDATE mefA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1603 UPDATE SHV-86 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1602 UPDATE AAC(6')-Iai antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1605 UPDATE cphA5 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1604 UPDATE CTX-M-84 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1607 UPDATE Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin antibiotic resistant gene variant or mutant; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1606 UPDATE CTX-M-16 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 809 UPDATE lnuB determinant of lincosamide resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 808 UPDATE TEM-171 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 803 UPDATE cphA4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 802 UPDATE QnrA3 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 801 UPDATE mfpA antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 800 UPDATE CTX-M-87 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 807 UPDATE OKP-B-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 806 UPDATE SHV-150 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 805 UPDATE MexC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 804 UPDATE tetB(P) antibiotic target protection protein; determinant of tetracycline resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1775 UPDATE QnrS7 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1774 UPDATE CTX-M-106 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1777 UPDATE OXA-177 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1776 UPDATE SHV-159 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1771 UPDATE TEM-19 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1770 UPDATE TEM-127 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1773 UPDATE tet(43) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1772 UPDATE aadA11 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1779 UPDATE CTX-M-12 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1778 UPDATE OKP-A-5 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 608 UPDATE OXA-361 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1159 UPDATE TEM-129 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1158 UPDATE SHV-22 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1155 UPDATE ACT-9 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1154 UPDATE TEM-146 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1157 UPDATE vanG determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1156 UPDATE Erm(31) antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1151 UPDATE OXA-240 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1150 UPDATE QnrVC5 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1153 UPDATE KPC-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1152 UPDATE CTX-M-39 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1555 UPDATE SHV-140 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1554 UPDATE norA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1551 UPDATE OXA-78 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1550 UPDATE smeR efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1553 UPDATE tetS antibiotic target protection protein; determinant of tetracycline resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1552 UPDATE MUS-1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 59 UPDATE OXA-256 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 58 UPDATE QnrB47 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1557 UPDATE SHV-187 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1556 UPDATE VIM-13 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 55 UPDATE OXA-69 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 54 UPDATE TEM-34 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 57 UPDATE SHV-24 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 56 UPDATE TEM-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 51 UPDATE AAC(3)-IIIc antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 50 UPDATE SME-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 53 UPDATE MOX-5 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 52 UPDATE OXY-2-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 537 UPDATE OXA-120 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 536 UPDATE TEM-95 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 535 UPDATE Morganella morganii gyrB conferring resistance to fluoroquinolone antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 534 UPDATE vanV determinant of resistance to glycopeptide antibiotics; antibiotic resistance gene cluster, cassette, or operon; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 533 UPDATE CARB-16 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 532 UPDATE CTX-M-47 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 531 UPDATE SAT-3 determinant of resistance to nucleoside antibiotics; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 530 UPDATE VIM-11 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 539 UPDATE QnrB59 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 538 UPDATE robA efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; ARO_accession; ARO_name; ARO_description; model_param; model_description; ARO_id; model_name "UPDATED ARO_accession with 3004108 UPDATED ARO_name with Enterobacter cloacae rob UPDATED ARO_description with rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. UPDATED param_value with 350 UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED ARO_id with 41229 UPDATED model_name with Enterobacter cloacae rob " 1558 UPDATE Bacillus subtilis mprF antibiotic target modifying enzyme; determinant of resistance to peptide antibiotics; gene altering cell wall charge; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with gene altering cell wall charge UPDATED category_aro_cvterm_id with 40190 UPDATED category_aro_accession with 3003580 UPDATED category_aro_description with Genes involved in alteration of the cell wall overall charge, leading to antimicrobial resistance due to reduced binding UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 429 UPDATE mdsA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 428 UPDATE OXY-2-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1399 UPDATE OXA-315 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1398 UPDATE OXA-108 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 421 UPDATE TEM-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 420 UPDATE CTX-M-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1395 UPDATE Neisseria gonorrhoeae mutant porin PIB (por) with reduced permeability to antibiotic determinant of tetracycline resistance; antibiotic resistant gene variant or mutant; determinant of beta-lactam resistance; protein modulating permeability to antibiotic; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. UPDATED param_description with A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms. DELETED blastp_evalue " 422 UPDATE FOX-10 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1393 UPDATE THIN-B beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 424 UPDATE SHV-36 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1391 UPDATE CTX-M-92 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 426 UPDATE aadK antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1443 UPDATE CARB-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1321 UPDATE mecA antibiotic resistance gene cluster, cassette, or operon; determinant of beta-lactam resistance; antibiotic target replacement protein; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2183 UPDATE glycopeptide resistance gene cluster VanB antibiotic resistance gene cluster, cassette, or operon; model_type "UPDATED model_type with gene cluster meta-model " 2182 UPDATE glycopeptide resistance gene cluster VanD antibiotic resistance gene cluster, cassette, or operon; model_type "UPDATED model_type with gene cluster meta-model " 2181 UPDATE glycopeptide resistance gene cluster VanF antibiotic resistance gene cluster, cassette, or operon; model_type "UPDATED model_type with gene cluster meta-model " 2180 UPDATE glycopeptide resistance gene cluster VanL antibiotic resistance gene cluster, cassette, or operon; model_type "UPDATED model_type with gene cluster meta-model " 2186 UPDATE glycopeptide resistance gene cluster VanG antibiotic resistance gene cluster, cassette, or operon; model_type "UPDATED model_type with gene cluster meta-model " 2185 UPDATE glycopeptide resistance gene cluster VanM antibiotic resistance gene cluster, cassette, or operon; model_type "UPDATED model_type with gene cluster meta-model " 2184 UPDATE glycopeptide resistance gene cluster VanC antibiotic resistance gene cluster, cassette, or operon; model_type "UPDATED model_type with gene cluster meta-model " 227 UPDATE OKP-B-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 226 UPDATE OXA-113 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 225 UPDATE CTX-M-88 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 224 UPDATE MIR-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 223 UPDATE GES-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 222 UPDATE JOHN-1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 221 UPDATE CMY-100 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 220 UPDATE TEM-92 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2213 UPDATE opmE efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2212 UPDATE mexQ efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2211 UPDATE mexP efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2217 UPDATE mexN efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2216 UPDATE mexM efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2215 UPDATE Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolone gene involved in self-resistance to antibiotic; antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2219 UPDATE MexL efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 151 UPDATE OKP-A-15 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 150 UPDATE catB3 determinant of phenicol resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 153 UPDATE adeF efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 152 UPDATE cpxA efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 155 UPDATE TEM-195 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 154 UPDATE mgrA efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 157 UPDATE dfrA21 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 156 UPDATE AAC(6')-Iaf antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2433 UPDATE lrfA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 158 UPDATE myrA antibiotic target modifying enzyme; gene involved in self-resistance to antibiotic; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2431 UPDATE hp1184 efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2430 UPDATE hp1181 efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2436 UPDATE D-Ala-D-Ala ligase determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; model_description; ARO_category; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2435 UPDATE lmrP efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2434 UPDATE Klebsiella OmpK36 conferring resistance to beta-lactam gene conferring resistance via absence; protein modulating permeability to antibiotic; ARO_description; model_description; model_param; ARO_name; model_name "UPDATED ARO_description with Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. UPDATED model_description with An AMR detection model for instances where the absence of a protein - due to large-scale insertion elements, large deletions, or other methods of protein knockout - confers clinical resistance to a known antibiotic. These models include reference sequences. Protein knockout models are currently in development. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue UPDATED ARO_name with Klebsiella pneumoniae OmpK36 UPDATED model_name with Klebsiella pneumoniae OmpK36 " 2724 UPDATE MuxABC-OpmB efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2720 UPDATE MuxC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2729 UPDATE MexJK-OprM efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 1807 UPDATE OXA-70 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1806 UPDATE OXA-14 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1805 UPDATE TEM-131 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1804 UPDATE OXA-107 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1803 UPDATE QnrVC3 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1802 UPDATE OXA-168 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1801 UPDATE AAC(6')-Ib11 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1800 UPDATE SHV-120 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1809 UPDATE QnrB5 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1808 UPDATE tet(A) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1256 UPDATE bmr efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1948 UPDATE TEM-167 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1949 UPDATE cphA6 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1257 UPDATE QnrB68 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1942 UPDATE BJP-1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1943 UPDATE Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid antibiotic resistant gene variant or mutant; determinant of isoniazid resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1940 UPDATE QnrB30 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1941 UPDATE SHV-98 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1946 UPDATE CTX-M-10 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1947 UPDATE CTX-M-160 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1944 UPDATE CTX-M-148 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1945 UPDATE SHV-50 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 818 UPDATE SHV-141 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 819 UPDATE CTX-M-68 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1255 UPDATE OXA-119 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2425 UPDATE hmrM efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 810 UPDATE mecC antibiotic resistance gene cluster, cassette, or operon; determinant of beta-lactam resistance; antibiotic target replacement protein; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 811 UPDATE TEM-26 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 812 UPDATE CMY-10 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 813 UPDATE OXA-216 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 814 UPDATE TEM-113 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 815 UPDATE GOB-1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 816 UPDATE OXA-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 817 UPDATE CTX-M-158 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1623 UPDATE GIM-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1250 UPDATE CTX-M-96 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1622 UPDATE vanWG determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1251 UPDATE CTX-M-157 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1621 UPDATE SHV-45 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1490 UPDATE SHV-107 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1397 UPDATE dfrC antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1492 UPDATE MOX-3 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1493 UPDATE PER-6 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1494 UPDATE LAT-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1495 UPDATE ACT-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1496 UPDATE OXA-224 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1497 UPDATE dfrA10 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1498 UPDATE cphA8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1499 UPDATE VEB-6 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 423 UPDATE DHA-16 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1626 UPDATE vgaE efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1700 UPDATE ACT-28 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1701 UPDATE Erm(39) antibiotic target modifying enzyme; determinant of lincosamide resistance; determinant of streptogramin resistance; determinant of macrolide resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1702 UPDATE MIR-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1703 UPDATE FosK antibiotic inactivation enzyme; determinant of fosfomycin resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1704 UPDATE CMY-57 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1705 UPDATE SHV-111 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1706 UPDATE OXA-142 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1707 UPDATE QnrB4 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1708 UPDATE tet36 antibiotic target protection protein; determinant of tetracycline resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1709 UPDATE TEM-115 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1624 UPDATE lmrD efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1392 UPDATE aadA22 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 427 UPDATE OCH-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1390 UPDATE arlR efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1629 UPDATE TEM-197 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1128 UPDATE OXA-23 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1129 UPDATE CMY-19 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1120 UPDATE IMI-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1121 UPDATE APH(3')-VIa antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1122 UPDATE OXA-180 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1123 UPDATE FOX-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1124 UPDATE TEM-186 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1125 UPDATE OKP-B-11 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1126 UPDATE OXA-184 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1127 UPDATE CTX-M-64 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 524 UPDATE dfrA25 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 525 UPDATE CMY-13 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 526 UPDATE ACT-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 527 UPDATE SHV-38 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1018 UPDATE APH(3')-IIc antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 521 UPDATE OXA-386 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 522 UPDATE floR efflux pump complex or subunit conferring antibiotic resistance; model_description; model_sequences; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. DELETED 99 UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 523 UPDATE OXA-75 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1014 UPDATE SHV-25 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1015 UPDATE evgA efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1016 UPDATE OXA-255 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1017 UPDATE CTX-M-86 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 528 UPDATE OCH-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 529 UPDATE SHV-185 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1012 UPDATE KPC-5 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1013 UPDATE APH(2'')-IIIa antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1234 UPDATE MIR-13 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1235 UPDATE AAC(6')-Ib' antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1236 UPDATE CMY-53 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1237 UPDATE Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin determinant of rifamycin resistance; antibiotic resistant gene variant or mutant; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a STOP codon. Nonsense SNPs truncate protein translation prematurely, resulting in a defective or completely inactive protein. In CARD, nonsense SNPs may be attached to models, and are recorded in the format: [wild type amino acid][position][STOP] (e.g. Q42STOP). This parameter is not currently used in detection algorithms. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. UPDATED param_description with A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms. DELETED blastp_evalue " 1230 UPDATE CTX-M-33 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1231 UPDATE mel efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1232 UPDATE cmeR efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1233 UPDATE tet32 antibiotic target protection protein; determinant of tetracycline resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1238 UPDATE OXA-397 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1239 UPDATE SHV-81 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " _version N/A N/A N/A N/A NEW: 1.1.9 , OLD: 1.1.8 438 UPDATE VIM-6 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 439 UPDATE SHV-83 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 436 UPDATE OXY-4-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 437 UPDATE SHV-69 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 434 UPDATE LEN-16 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 435 UPDATE OKP-A-9 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 432 UPDATE sav1866 efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 433 UPDATE ACT-25 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 430 UPDATE OXA-87 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 431 UPDATE Escherichia coli marR mutant conferring antibiotic resistance efflux pump complex or subunit conferring antibiotic resistance; antibiotic resistant gene variant or mutant; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a STOP codon. Nonsense SNPs truncate protein translation prematurely, resulting in a defective or completely inactive protein. In CARD, nonsense SNPs may be attached to models, and are recorded in the format: [wild type amino acid][position][STOP] (e.g. Q42STOP). This parameter is not currently used in detection algorithms. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1630 UPDATE IMP-13 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1961 UPDATE TEM-105 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 238 UPDATE SHV-137 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 239 UPDATE OXA-83 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 234 UPDATE QnrS8 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 235 UPDATE OXA-181 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 236 UPDATE ACT-19 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 237 UPDATE BlaB beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 230 UPDATE OXA-422 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 231 UPDATE OXA-178 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 232 UPDATE imiH antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 233 UPDATE LEN-21 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 993 UPDATE AAC(6')-Ib9 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2228 UPDATE PEDO-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2229 UPDATE PEDO-2 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2227 UPDATE VCC-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2224 UPDATE Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem protein modulating permeability to antibiotic; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2222 UPDATE VEB-1b antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2223 UPDATE MexZ efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; model_type; model_description; model_param "UPDATED model_type with protein overexpression model UPDATED model_description with This model detects protein overexpression based on the presence of mutations.The detection of the protein without an associated mutation indicates that the protein is likely to be expressed at low or basal levels. The detection of the protein with the mutation indicates that the protein is likely overexpressed. This model reflects how certain proteins are functional with and without mutations. For example, efflux pump subunits and regulators are functional with mutations and without mutations. Without mutations, efflux pump subunits and regulators are usually expressed at a low level. When an efflux pump regulator has a mutation, it can cause the overexpression of the efflux pump it is responsible for regulating, leading to resistance to specific drugs. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2221 UPDATE VEB-1a antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1 UPDATE PDC-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 146 UPDATE OXA-98 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 147 UPDATE OXA-27 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 144 UPDATE IMP-12 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 145 UPDATE OXA-229 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 142 UPDATE tet(E) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 143 UPDATE cphA7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 140 UPDATE AAC(6')-IIb antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 141 UPDATE vanRB determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 148 UPDATE SHV-92 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 149 UPDATE aadA12 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2088 UPDATE Mycobacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2700 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2083 UPDATE Mycoplasma hominis parC conferring resistance to fluoroquinolone gene involved in self-resistance to antibiotic; antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2080 UPDATE Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2700 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2081 UPDATE patA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2086 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline antibiotic resistant gene variant or mutant; determinant of tetracycline resistance; model_description; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2700 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2087 UPDATE aadA13 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2084 UPDATE Mycobacterium abscessus 16S rRNA mutation conferring resistance to amikacin antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2600 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2085 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2700 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2712 UPDATE MexXY-OprA efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2713 UPDATE MexXY-OprM efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2711 UPDATE MexXY-OprM efflux pump complex or subunit conferring antibiotic resistance; model_type; model_description; model_param "UPDATED model_type with efflux pump system meta-model UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems) UPDATED param_description with This parameter describes efflux pump components that are to be detected together (e.g., efflux pump subunits and regulators) using sequential model IDs, separated by commas. For example: 2685,440,1925,1305. " 2716 UPDATE OpmB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2717 UPDATE MuxA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2718 UPDATE MuxB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1832 UPDATE QnrS2 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1833 UPDATE OXA-374 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1830 UPDATE APH(3'')-Ib antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1831 UPDATE AAC(6')-Iid antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1836 UPDATE OXA-201 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1837 UPDATE CTX-M-59 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1834 UPDATE TEM-94 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1835 UPDATE tet(38) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1838 UPDATE ACT-5 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1839 UPDATE aadA14 antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2154 UPDATE Borrelia burgdorferi 16S rRNA mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2500 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2155 UPDATE Propionibacterium acnes 16S rRNA mutation conferring resistance to tetracycline antibiotic resistant gene variant or mutant; determinant of tetracycline resistance; model_description; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2600 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2156 UPDATE NDM-14 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2405 UPDATE Neisseria gonorrhoeae parC conferring resistance to fluoroquinolone antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2402 UPDATE Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2403 UPDATE Salmonella enterica gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 2152 UPDATE Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin antibiotic resistant gene variant or mutant; determinant of aminoglycoside resistance; model_description; model_sequences; model_param "UPDATED model_description with An AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown to confer elevated resistance to antibiotic(s) relative to the wild-type rRNA sequence. rRNA mutation models include a reference rRNA sequence, a BLASTN bitscore cutoff and mapped potential resistance variants. A submitted sequence must include a known resistance variant to be detected. UPDATED fmax with 62514 UPDATED strand with + UPDATED accession with NC_003112 UPDATED fmin with 60970 UPDATED sequence with TGAACATAAGAGTTTGATCCTGGCTCAGATTGAACGCTGGCGGCATGCTTTACACATGCAAGTCGGACGGCAGCACAGAGAAGCTTGCTTCTCGGGTGGCGAGTGGCGAACGGGTGAGTAACATATCGGAACGTACCGAGTAGTGGGGGATAACTGATCGAAAGATCAGCTAATACCGCATACGTCTTGAGAGAGAAAGCAGGGGACCTTCGGGCCTTGCGCTATTCGAGCGGCCGATATCTGATTAGCTAGTTGGTGGGGTAAAGGCCTACCAAGGCGACGATCAGTAGCGGGTCTGAGAGGATGATCCGCCACACTGGGACTGAGACACGGCCCAGACTCCTACGGGAGGCAGCAGTGGGGAATTTTGGACAATGGGCGCAAGCCTGATCCAGCCATGCCGCGTGTCTGAAGAAGGCCTTCGGGTTGTAAAGGACTTTTGTCAGGGAAGAAAAGGCTGTTGCTAATATCAGCGGCTGATGACGGTACCTGAAGAATAAGCACCGGCTAACTACGTGCCAGCAGCCGCGGTAATACGTAGGGTGCGAGCGTTAATCGGAATTACTGGGCGTAAAGCGGGCGCAGACGGTTACTTAAGCAGGATGTGAAATCCCCGGGCTCAACCCGGGAACTGCGTTCTGAACTGGGTGACTCGAGTGTGTCAGAGGGAGGTAGAATTCCACGTGTAGCAGTGAAATGCGTAGAGATGTGGAGGAATACCGATGGCGAAGGCAGCCTCCTGGGACAACACTGACGTTCATGCCCGAAAGCGTGGGTAGCAAACAGGATTAGATACCCTGGTAGTCCACGCCCTAAACGATGTCAATTAGCTGTTGGGCAACCTGATTGCTTGGTAGCGTAGCTAACGCGTGAAATTGACCGCCTGGGGAGTACGGTCGCAAGATTAAAACTCAAAGGAATTGACGGGGACCCGCACAAGCGGTGGATGATGTGGATTAATTCGATGCAACGCGAAGAACCTTACCTGGTCTTGACATGTACGGAATCCTCCGGAGACGGAGGAGTGCCTTCGGGAGCCGTAACACAGGTGCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTGTCATTAGTTGCCATCATTCAGTTGGGCACTCTAATGAGACTGCCGGTGACAAGCCGGAGGAAGGTGGGGATGACGTCAAGTCCTCATGGCCCTTATGACCAGGGCTTCACACGTCATACAATGGTCGGTACAGAGGGTAGCCAAGCCGCGAGGCGGAGCCAATCTCACAAAACCGATCGTAGTCCGGATTGCACTCTGCAACTCGAGTGCATGAAGTCGGAATCGCTAGTAATCGCAGGTCAGCATACTGCGGTGAATACGTTCCCGGGTCTTGTACACACCGCCCGTCACACCATGGGAGTGGGGGATACCAGAAGTAGGTAGGATAACCACAAGGAGTCCGCTTACCACGGTATGCTTCATGACTGGGGTGAAGTCGTAACAAGGTAGCCGTAGGGGAACCTGCGGCTGGATCACCTCCTTTCT UPDATED NCBI_taxonomy_name with Neisseria meningitidis MC58 UPDATED NCBI_taxonomy_id with 122586 UPDATED NCBI_taxonomy_cvterm_id with 39597 UPDATED accession with UPDATED sequence with UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED 41093 UPDATED param_value with 2700 UPDATED param_type_id with 41093 UPDATED param_type with BLASTN bit-score UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. " 2401 UPDATE Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 933 UPDATE OKP-A-14 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 932 UPDATE GES-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 931 UPDATE OXA-316 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 937 UPDATE OXA-242 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 936 UPDATE OKP-A-13 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 935 UPDATE OXA-314 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2409 UPDATE Neisseria meningititis PBP2 conferring resistance to beta-lactam antibiotic resistant gene variant or mutant; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 1955 UPDATE OXA-29 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1954 UPDATE TEM-154 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1957 UPDATE VIM-18 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1956 UPDATE IMI-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1951 UPDATE TEM-76 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1950 UPDATE arr-1 determinant of rifamycin resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1953 UPDATE SHV-155 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1952 UPDATE OXA-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1959 UPDATE ACT-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1958 UPDATE VIM-33 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 829 UPDATE DHA-17 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 828 UPDATE TEM-83 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 825 UPDATE SHV-20 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 824 UPDATE vanD determinant of resistance to glycopeptide antibiotics; protein(s) conferring antibiotic resistance via molecular bypass; antibiotic resistance gene cluster, cassette, or operon; model_description; ARO_category; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED category_aro_name with protein(s) conferring antibiotic resistance via molecular bypass UPDATED category_aro_description with Proteins involved in restructuring of the cell wall, causing antibiotic resistance. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 827 UPDATE QnrB55 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 826 UPDATE TolC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 821 UPDATE Mycobacterium tuberculosis embB mutants conferring resistance to rifampicin determinant of rifamycin resistance; antibiotic resistant gene variant or mutant; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 820 UPDATE mdtB efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 823 UPDATE cat determinant of phenicol resistance; antibiotic inactivation enzyme; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 822 UPDATE QnrD1 antibiotic target protection protein; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1536 UPDATE OXA-421 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1483 UPDATE AAC(3)-Xa antibiotic inactivation enzyme; determinant of aminoglycoside resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1482 UPDATE SME-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1481 UPDATE OXY-1-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1480 UPDATE EXO beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1487 UPDATE SHV-48 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1486 UPDATE CARB-12 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1485 UPDATE MOX-8 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1484 UPDATE ACT-27 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1489 UPDATE CMY-37 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1488 UPDATE TEM-75 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 797 UPDATE TEM-55 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2411 UPDATE Shigella flexneri gyrA conferring resistance to fluoroquinolones antibiotic resistant gene variant or mutant; determinant of fluoroquinolone resistance; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 795 UPDATE OXA-324 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 794 UPDATE Staphylococcus aureus rpoC conferring resistance to daptomycin antibiotic resistant gene variant or mutant; determinant of resistance to lipopeptide antibiotics; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 793 UPDATE IMP-34 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 792 UPDATE OXY-1-1 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 791 UPDATE SHV-14 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 929 UPDATE GES-10 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1719 UPDATE ceoA efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1718 UPDATE DIM-1 beta-lactamase antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 799 UPDATE CTX-M-31 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 798 UPDATE cmeC efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 612 UPDATE PDC-7 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 2144 UPDATE Mycobacterium bovis embB mutations conferring resistance to ethambutol antibiotic resistant gene variant or mutant; determinant of resistance to polyamine antibiotics; model_description; model_param "UPDATED model_description with Protein variant models perform a similar search to protein homolog models, but secondarily screen query sequences for curated sets of mutations to differentiate between wild type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. For example, a protein that confers elevated resistance to antibiotic(s) relative to wild type. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences. DELETED blastp_evalue " 613 UPDATE VEB-4 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1272 UPDATE CTX-M-67 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1139 UPDATE dfrA12 antibiotic target replacement protein; determinant of diaminopyrimidine resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1138 UPDATE tet(D) efflux pump complex or subunit conferring antibiotic resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bitscore parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences. DELETED blastp_evalue " 1133 UPDATE SHV-109 antibiotic inactivation enzyme; determinant of beta-lactam resistance; model_description; model_param "UPDATED model_description with Protein homolog models detect protein sequences based on their similarity to curated reference sequence, using curated BLASTP cut-offs. CARD cut-offs are currently based on BLAST bitscore cutoffs as they are independent of database size and query length. UPDATED param_description with A score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (λ × S − lnK)/ ln2 where λ is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix.