{"$update": {"1226": {"$update": {"model_sequences": {"$update": {"sequence": {"4251": {"dna_sequence": {"fmax": "1221", "fmin": "0", "accession": "CT025800.2", "strand": "+", "sequence": "ATGTCATTTTCCCGCAAACAGTTTGCACTGTCTGCCATCTTTGTCGCTATTTTAGCAACCGGTGGCAGTTTTATGTTGTTACATGAAAATGCCGATGCAAAAGCTGCACCAACCGCTGCCCAACAAGCTGCTACTGTTGATGTAGCCCCAGTAGTAAGCAAAACCATTACCGATTGGCAAGAATATTCCGGTCGTTTAGAAGCAATTGATCAAGTTGATATTCGGCCTCAAGTTTCAGGAAAACTTATTGCCGTACATTTCAAAGATGGAAGCCTCGTTAAAAAAGGTGATTTACTTTTCACAATCGACCCTCGTCCTTTTGAAGCAGAACTGAACCGTGCAAAAGCCCAACTTGCTTCAGCTGAAGCACAGGTAACATATACCGCAAGCAATCTTTCGCGTATTCAACGTCTCATTCAGAGTAATGCTGTTTCTCGCCAAGAACTGGATTTAGCCGAAAATGATGCACGTTCAGCGAATGCTAACCTACAAGCCGCTAGAGCTGCTGTCCAATCTGCACGTTTAAATCTAGAATACACCCGTATTACAGCACCTGTCAGCGGCCGGATTTCACGAGCTGAAGTCACCGTTGGTAATGTAGTTTCTGCAGGTAACGGCGCACAGGTTTTAACAAGTTTAGTGTCTGTATCCCGCCTTTATGCATCTTTCGATGTTGATGAACAAACTTACCTGAAATATATCAGTAATCAGCGTAATTCAGCACAAGTACCTGTCTATATGGGACTTGCCAATGAAACAGGCTTTACTCGTGAAGGTACAATCAACTCAATCGATAACAATCTGAATACAACCTCAGGTACGATCCGTGTTCGCGCAACTTTTGACAATCCAAACGGTGTTTTATTACCAGGCCTATATGCACGAATTCGTTTAGGTGGAGGCCAACCTCGCCCAGCGATTCTGATTAGTCCAACCGCGGTTGGTGTCGACCAAGATAAACGTTTTGTCGTAGTAGTAGATGCGAAAAATCAAACTGCTTATCGCGAAGTAAAACTCGGTGCCCAACAAGATGGCTTGCAAATCGTAAATAGCGGATTACAAGCGGGTGATCGTATTGTAGTGAATGGTTTACAACGGATTCGTCCGGGTGACCCTGTTACACCGCATCTCGTCCCTATGCCAAATTCACAAATCACTGCTAGCGCTACTCCTCCTCAACCTCAGCCAACAGATAAAACATCAACTCCGGCAAAAGGTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii AYE", "NCBI_taxonomy_id": "509173", "NCBI_taxonomy_cvterm_id": "35535"}, "protein_sequence": {"accession": "CAJ77857.1", "sequence": "MSFSRKQFALSAIFVAILATGGSFMLLHENADAKAAPTAAQQAATVDVAPVVSKTITDWQEYSGRLEAIDQVDIRPQVSGKLIAVHFKDGSLVKKGDLLFTIDPRPFEAELNRAKAQLASAEAQVTYTASNLSRIQRLIQSNAVSRQELDLAENDARSANANLQAARAAVQSARLNLEYTRITAPVSGRISRAEVTVGNVVSAGNGAQVLTSLVSVSRLYASFDVDEQTYLKYISNQRNSAQVPVYMGLANETGFTREGTINSIDNNLNTTSGTIRVRATFDNPNGVLLPGLYARIRLGGGQPRPAILISPTAVGVDQDKRFVVVVDAKNQTAYREVKLGAQQDGLQIVNSGLQAGDRIVVNGLQRIRPGDPVTPHLVPMPNSQITASATPPQPQPTDKTSTPAKG"}}}}}}}, "153": {"$update": {"model_sequences": {"$update": {"sequence": {"4252": {"dna_sequence": {"fmax": "3180", "fmin": "0", "accession": "CT025801.2", "strand": "+", "sequence": "ATGAATATTTCTAAATTTTTTATTGATCGGCCGATCTTTGCTGGTGTGCTATCAGTCTTGATTTTACTCGCCGGTCTCCTTTCGGTATTTCAGTTACCGATTTCTGAATATCCCGAGGTTGTTCCACCATCTGTGGTGGTACGCGCCCAATATCCGGGTGCAAACCCAAAAGTGATTGCTGAAACGGTTGCATCTCCGCTCGAAGAGTCAATCAACGGCGTCGAAGACATGCTGTATATGCAATCTCAAGCAAACAGCGACGGTAACCTAACCATTACGGTGAACTTTAAGCTCGGTATCGACCCAGACAAAGCCCAACAATTGGTTCAAAACCGTGTGTCTCAGGCCATGCCCCGTTTACCTGAAGATGTACAGCGCTTAGGTGTAACCACACTAAAAAGCTCACCTACTTTAACTATGGTAGTGCATCTGACCTCACCAGATAATCGCTATGACATGACCTACTTACGTAACTATGCGGTGCTCAACGTGAAAGACCGTTTAGCGCGTTTACAAGGGGTTGGTGAAGTCGGATTATTTGGTTCTGGTGACTACGCGATGCGTGTATGGCTTGACCCGCAAAAAGTAGCGCAGCGTAACCTCACCGCGACCGAAATTGTGAATGCAATCCGTGAACAAAATATTCAGGTTGCAGCGGGTACAATCGGTGCATCACCAAGTAATTCACCTTTACAGCTTTCAGTCAATGCTCAAGGTCGTTTAACTACTGAACAAGAATTCGCAGATATCATTTTAAAAACTGCACCAGATGGCGCGGTTACCCGATTGGGTGATGTTGCTCGTGTCGAACTTGCAGCCTCTCAATATGGCTTACGTTCATTGCTTGATAATAAACAAGCGGTCGCGATTCCAATTTTCCAAGCACCGGGTGCGAATGCTTTACAAGTTTCCGATCAAGTGCGTAGCACAATGAAGGAGCTTTCAAAAGATTTCCCATCTTCAATTAAATACGACATTGTTTATGACCCGACTCAATTCGTACGTGCAAGTATTAAAGCGGTCGTTCATACCTTACTTGAAGCAATTACACTGGTTGTTGTGGTCGTTATTTTATTCTTGCAAACATGGCGTGCCTCAATCATTCCATTGCTTGCCGTACCGGTTTCAATTATTGGTACATTCGCGCTCATGCTCGCTTTTGGTTACTCAATCAATGCGCTATCACTGTTCGGAATGGTACTTGCCATCGGGATTGTCGTCGATGACGCGATTGTGGTCGTCGAAAATGTCGAGAGGAATATTGAAGCAGGCTTAAACCCAAGGGAGGCGACTTACCGTGCCATGCGAGAAGTCAGTGGACCGATTATTGCCATTGCTTTAACACTTGTTGCAGTATTCGTACCTCTTGCCTTTATGACAGGCTTAACAGGGCAATTCTATAAACAATTTGCCATGACCATTGCCATTTCAACGGTTATTTCGGCATTTAACTCGCTTACCCTATCTCCTGCTTTGGCAGCGCTGTTACTGAAAGGACATGATGCTAAACCGGATGCCTTAACACGTATTATGAATCGTGTATTCGGTCGTTTCTTTGCACTGTTTAACCGTGTGTTTTCACGTGCTTCAGACCGTTATAGTCAAGGCGTCAGCCGTGTCATTTCCCATAAAGCTTCGGCAATGGGTGTCTATGCAGCACTCTTAGGTTTAACCGTTGGTATTTCCTATATTGTTCCAGGTGGTTTCGTTCCTGCGCAGGACAAACAATATTTAATTAGCTTTGCGCAGCTACCAAACGGCGCATCATTAGATCGTACCGAAGCGGTCATTCGTAAAATGAGTGACACTGCACTTAAACAACCTGGTGTAGAAAGTGCAGTTGCCTTTCCTGGCCTATCAATTAACGGTTTCACCAATAGCTCAAGTGCCGGTATTGTCTTTGTGACTTTAAAGCCATTTGATGAACGTAAGGCAAAAGACTTATCTGCAAATGCAATTGCAGGTGCGCTCAACCAGAAATATTCAGCTATTCAAGATGCCTATATCGCGGTTTTCCCACCGCCACCAGTGATGGGCTTAGGTACTATGGGCGGCTTTAAACTACAACTTGAAGACCGAGGTGCCTTAGGCTATTCAGCCTTGAACGATGCTGCACAAAACTTTATGAAGGCAGCACAATCAGCCCCTGAACTGGGTCCAATGTTCTCAAGTTATCAAATTAACGTACCTCAACTCAACGTAGATCTGGACCGTGTAAAAGCTAAACAGCAAGGCGTTGCTGTGACAGATGTTTTCAATACTATGCAGATTTATTTAGGTTCTCAGTACGTTAACGACTTTAACCGCTTTGGACGTGTTTATCAGGTTCGTGCACAAGCCGATGCGCCTTTCCGTGCTAACCCTGAAGATATTTTGCAGCTTAAAACCCGTAATAGTGCCGGACAAATGGTGCCATTATCTTCATTGGTGAATGTAACTCAAACCTATGGTCCTGAAATGGTCGTTCGTTATAACGGTTACACATCAGCAGATATTAACGGTGGCCCTGCCCCAGGTTATTCATCTAGCCAAGCAGAAGCTGCGGTTGAACGTATTGCTGCACAAACTCTACCGCGTGGTATCAAGTTTGAATGGACAGATTTAACTTATCAAAAAATCTTGGCTGGTAATGCTGGACTTTGGGTATTCCCTATTAGCGTATTACTCGTGTTCTTAGTGTTAGCTGCTCAGTATGAAAGCTTAACCCTACCATTAGCAGTTATCTTAATTGTACCAATGGGAATCTTAGCGGCTCTGACAGGTGTCTGGTTGACAGCTGGAGATAACAACATCTTTACTCAAATCGGTCTAATGGTACTGGTCGGGCTAGCCTGTAAAAATGCCATCTTAATTGTCGAATTTGCGAGGGAACTTGAAATGCAAGGTGCGACTGCCTTTAAAGCAGCCGTTGAAGCAAGTCGTCTACGTTTACGCCCAATTTTAATGACCTCTATTGCATTTATTATGGGTGTAGTGCCACTGGTTACTTCAACTGGCGCAGGTTCTGAAATGCGACATGCGATGGGTGTTGCCGTATTCTTCGGTATGATCGGTGTAACATTCTTTGGTTTATTCCTCACCCCGGCCTTTTACGTTCTGATTCGTACCCTCAACAGCAAACATAAACTGCATTCTGCGGCAGTTCATGAAGCGCCGTTAGCTAGCCCACATGATCATTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii AYE", "NCBI_taxonomy_id": "509173", "NCBI_taxonomy_cvterm_id": "35535"}, "protein_sequence": {"accession": "CAJ77856.1", "sequence": "MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPSNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIRTLNSKHKLHSAAVHEAPLASPHDH"}}}}}, "model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "750"}}}}}}, "215": {"$update": {"ARO_category": {"$update": {"39982": {"$update": {"category_aro_name": "undecaprenyl pyrophosphate related proteins"}}}}}}, "603": {"$update": {"model_sequences": {"$update": {"sequence": {"4258": {"dna_sequence": {"fmax": "1192954", "fmin": "1191727", "accession": "CP000800.1", "strand": "-", "sequence": "TCAGTTCGATACCTGGGGTATTCGACGACGACGTAGACTGTTCCATGAATAGACTGCGTTGAATAACACTACGCCAGCGGTGACGAGAAATACCGCTCTGAAACCGTAGTTCGCTGAAATCGCTGCTCCCATCAATGGTCCGGTAACGTTGCCAATATCACGAAACGATTGGTTATAGCTGAAGATACGCCCGGCGATCTGGTTGCTCGAGTTGTAAACCAACAGTGTCTGTACGGCGGGGAGTAGTGCACCATCGGCGGCACCGAGCAAAAAACGTAAAATCCCAAGTTGCAATGGCGTCTGAACGTAAGACATTGGGATCAACAGCAGTACAGAAAAGATCAGCGCTGTAATCAGGATCTTTTCGGGTCCGATTCGATCGCCAAGTTTGCCGAGTCGTGGTGCACTTAGCAGAGCCGCCACGCCTGGCACCGAGGCGATCATGCCACTGATAAAGGCGACGTTACTGACGTTACCCGCCAGTTCGCGGACATACAGCGTCAGAATGGGGGCAATTGAGCCCGTCGCCACCTGGATGATTAACGTAGTGACAAACAGGCTGAGTACCAGTTTCGGGTTTTTAAGTGATGTCACCACTTCCCGCATGTGCAGCATCTCTTTTTTGCTGACCGGCTGGAATTTTTCTCTGATGCAAAACAGGGTGACGAAAAAGCAGAGTATGAGCACACTGGCGGTAATAAAGAATACCGGACGTAAGCCGTAGCTATCGGCGAGCAGGCCGCCAGCCATTGGGCCGAGCAACGCACCACTAACGCCGCCTGTGGAGAGCGTACCCAGCGCCCAGCCGCTTTTATTACGCGGTACTTGTGTGGCGATAAGAGCATTAGCGTTGGGGACAAATCCGCCAAGTAACCCAAGAAGCGCCCGTAGGATCAAAAACTGCCAGATATTTTGTGCCAGTCCCATCAACACCATCACGATGCCCATGCCGAGAGCAGAGCGTAATAGCATGAGTTTTCGACCTTTACGGTCGGCGAGTCCACCCCAAAACGGTGAGGCGATGGCCGAAAATAAAAATGTAATGCTGAAGACAATACCGGACCACATATTCAGGGCGGAGTGGCCGGTAACACCAAGCTGCTCAACGTAGAGGGGTAAGAAGGGCATTACCAGACTGAAGGCGGCCCCGGTAAGAAAACAGCCTAGCCAGGCGACGATCAGGTTTCGTTTCCAGTTTATAGGGGTGTCATTTTCACAGGGTGACAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli O139:H28 str. E24377A", "NCBI_taxonomy_id": "331111", "NCBI_taxonomy_cvterm_id": "41529"}, "protein_sequence": {"accession": "ABV18113.1", "sequence": "MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQVSN"}}}}}}}, "882": {"$update": {"ARO_description": "RCP is a class A beta-lactamase found in Rhodopseudomonas capsulata.", "ARO_category": {"$update": {"41399": {"$update": {"category_aro_name": "RCP beta-lactamase", "category_aro_description": "A family of class A beta-lactamases that have been discovered in the Rhodobacter genus."}}}}, "model_name": "RCP-1", "ARO_name": "RCP-1"}}, "571": {"$update": {"model_sequences": {"$update": {"sequence": {"4248": {"dna_sequence": {"fmax": "540745", "fmin": "539695", "accession": "CP006845.1", "strand": "+", "sequence": "ATGCAACAAAAAAACAAGTATATAAGAATCCAAGAGTTCCTGAAGCAAAATAAATTTCCTGATTTTAGAATGAATCAAATCAAAAATGCTGTATTCCAAGGGAGAATAAATCATTTCAATGAAATAACGGTTCTTCCTAAATCCCTGAGAAAATTGTTAATAGAGGAGTTCGGAGAGTCGATTTTAAATATTGCTCCTTTAAAAGTGCAGCATTCTGAGCAAGTAACAAAAGTCTTATTTGAAATTTCCGGAGACGAAAAAATAGAAACGGTTAATATGAAATATAAAGCCGGTTGGGAGTCATTTTGTATATCCTCGCAGTGCGGCTGTCATTTCGGCTGTAAATTTTGTGCAACAGGAGATATTGGTTTAAAACGCAATTTAACGTCAGATGAAATGACTGACCAAATTTTGTACTTTCACTTAAAAGGACATTCAATTGACAGTATTTCTTTTATGGGAATGGGAGAAGCATTAGCGAATGTACAAGTTTTTGATGCTTTACATGTGCTTACAAATCCGGAGTTGTTTGCTTTAAGCCCTCGCAGGTTATCTATTTCGACTATAGGTATTATTCCGGGCATTAAAAAAATCACTCAGGATTATCCGCAGGTCAACCTGACGTTTTCATTACATTCTCCTTTTAATGAACAGCGAAGCAAGTTAATGCCGATTAATGAACGCTACCCGTTATTGGAGGTAATGGACACATTAGATGAGCATATACGTGTGACCTCAAGAAAAGTTTATATTGCTTATATTATGCTGCCGGGAGTTAATGATTCTATTGATCATGCGAATGAAGTAGTAAATCTTTTAAGAAGCAGATATAAGAGAGGGAACTTGTTCCATGTAAACATCATTAGATATAACCCGACTGTTAGTTCACCTATGAGATTTGAAGAAGTAAATGAGAAACAAGTTGTAAACTTCTATAAAAAATTAAAGTCAGCAGGAATTAACGTGACCGTCAGAAGTCAATTTGGTATTGATATAGATGCTGCTTGCGGACAATTATATGGAAATTATCAAAAAAATAAGAACCAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacillus amyloliquefaciens CC178", "NCBI_taxonomy_id": "1412898", "NCBI_taxonomy_cvterm_id": "41528"}, "protein_sequence": {"accession": "AGZ55247.1", "sequence": "MQQKNKYIRIQEFLKQNKFPDFRMNQIKNAVFQGRINHFNEITVLPKSLRKLLIEEFGESILNIAPLKVQHSEQVTKVLFEISGDEKIETVNMKYKAGWESFCISSQCGCHFGCKFCATGDIGLKRNLTSDEMTDQILYFHLKGHSIDSISFMGMGEALANVQVFDALHVLTNPELFALSPRRLSISTIGIIPGIKKITQDYPQVNLTFSLHSPFNEQRSKLMPINERYPLLEVMDTLDEHIRVTSRKVYIAYIMLPGVNDSIDHANEVVNLLRSRYKRGNLFHVNIIRYNPTVSSPMRFEEVNEKQVVNFYKKLKSAGINVTVRSQFGIDIDAACGQLYGNYQKNKNQ"}}}}}}}, "1206": {"$update": {"ARO_description": "QepA1 is a plasmid-mediated efflux pump in E. coli, shown to contribute to fluoroquinolone resistance. It is regulated by sox genes, also known as global stress regulators.", "ARO_name": "QepA1"}}, "593": {"$update": {"model_sequences": {"$update": {"sequence": {"4255": {"dna_sequence": {"fmax": "1249348", "fmin": "1249018", "accession": "CP001172.1", "strand": "-", "sequence": "TTATAGATGGGTGTTTTTAGAAAACACATTAATAATCACAATGCCTGCGATCATTAAAGCTAAACCAATGCAGGCAGCTAAGTCTAAATGTTGTTTGTAAAATATCCAGCCAATTGCAGAAATTAAAATAATACCTGCGCCTGACCAAATGGCATAGGCAATCCCGATTGGAATTGTTTTGAGCGTAAGAGATAATAAATAAAAAGCAACTGCATAACCCACAACTGTAATAATAGACGGAATTGGAACAGTAAAACCTTGAGATGCTTTTAATGCTGAAGTTGCAATAACTTCACAAGCAATCGCAATTGCTAAATAAAGATAAGACAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii AB307-0294", "NCBI_taxonomy_id": "557600", "NCBI_taxonomy_cvterm_id": "35595"}, "protein_sequence": {"accession": "ACJ59254.1", "sequence": "MSYLYLAIAIACEVIATSALKASQGFTVPIPSIITVVGYAVAFYLLSLTLKTIPIGIAYAIWSGAGIILISAIGWIFYKQHLDLAACIGLALMIAGIVIINVFSKNTHL"}}}}}, "model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "175"}}}}}}, "_version": "2.0.1", "2823": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"8308": "G2057A"}, "clinical": {"8308": "G2057A"}}}}}}}, "1544": {"$update": {"model_sequences": {"$update": {"sequence": {"4233": {"dna_sequence": {"fmax": "234307", "fmin": "233812", "accession": "AIIS01000002.1", "strand": "-", "sequence": "TTATTTATCGTTTCGATGATACGTTTCATAGTCATGTGCATAGAGATTTTTCTCGTCCACGACGCCGGGAACAGTGGCAACTTTTTCCCAAACAAACCAGTCGATTTCTGGAAAGAAAGTGTCGCCTTCAAACGTTTCATGAATCATCGTCCGATATAAGACATCGCATGCGGGAATCAGTTCTTTAAAAACGACAGAACCTCCACCAATAACGGTCACACCTTCATAGTTGTCAGCATACGCAAGAATTTCCTCTACGGAATGCATAACCAAAACGCCTTCAGCTCGGTAATCCGGATTACTGGTTAGGACAATCGTTGTTCGATTTGGTAGCGGACGACATCCCATGCCTTCGAAAGTTGCACGTCCTAAGACCAATGTATTATGAATTGTTTTTTCCTTGAAAAATTTCAAGTCATTGGGTAAATGCCAAGGCAATTTGCCTTCTTTACCAATCACTCCTTGTTCATCTTGGGCCCAAATAGCTGCTAACAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecalis EnGen0074", "NCBI_taxonomy_id": "1151194", "NCBI_taxonomy_cvterm_id": "41527"}, "protein_sequence": {"accession": "EOD99669.1", "sequence": "MLAAIWAQDEQGVIGKEGKLPWHLPNDLKFFKEKTIHNTLVLGRATFEGMGCRPLPNRTTIVLTSNPDYRAEGVLVMHSVEEILAYADNYEGVTVIGGGSVVFKELIPACDVLYRTMIHETFEGDTFFPEIDWFVWEKVATVPGVVDEKNLYAHDYETYHRNDK"}}}}}}}, "694": {"$update": {"model_sequences": {"$update": {"sequence": {"4239": {"dna_sequence": {"fmax": "1079", "fmin": "206", "accession": "AY750914.2", "strand": "+", "sequence": "ATGAGACATCGCGTTAAGCGGATGATGCTAATGACAACGGCCTGTATTTCGCTGTTGCTGGGGAGTGCGCCGCTGTATGCGCAGGCGAACGACGTTCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGGGGGCGGTTGGGAGTGGCGCTGATTGACACCGCCGATAACGCACAGACGCTCTACCGCGCCGACGAGCGCTTTGCCATGTGCAGCACCAGTAAGGTGATGGCAGCCGCGGCGGTGCTCAAGCAAAGTGAAACGCAAAAGAACGTGTTGAGTCAGAAGGTTGAGATTAAATCCTCGGACCTGATTAACTACAATCCCATCGCTGAAAAACACGTCAACGGCACGATGACGCTGGCGGAATTGAGCGCCGCGGCGTTGCAGTACAGCGATAATACGGCCATGAACAAGCTGATTGCCCATCTTGGGGGGCCGGATAAAGTGACGGCGTTTGCCCGTGCGATTGGGGATGACACCTTCCGGCTCGATCGTACTGAGCCGACGCTCAACACCGCGATCCCCGGCGACCCGCGCGATACCACCACGCCATTAGCGATGGCGCAGACGCTTCGCCATCTGACGTTGGGCAGTGCCTTAGGTGAAACTCAGCGTGCGCAACTGGTAACGTGGCTGAAAGGCAACACCACCGGTGCTGCCAGCATTCAGGCTGGGCTACCCACATCGTGGGTTGTCGGGGATAAAACCGGCAGCGGTGATTATGGTACGACGAATGACATCGCCGTCATCTGGCCGGAAGGGCGTGCGCCGCTTATTCTGGTCACTTACTTCACCCAACCGGAGCAGAAGGCAGAAAGTCGTCGTGACGTGCTCGCGGCTGCCGCGAAAATCGTCACCGACGGTTATTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAV28215.2", "sequence": "MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVALIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIKSSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSALGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLILVTYFTQPEQKAESRRDVLAAAAKIVTDGY"}}}}}}}, "542": {"$update": {"model_sequences": {"$update": {"sequence": {"4253": {"dna_sequence": {"fmax": "1452", "fmin": "0", "accession": "CT025802.2", "strand": "+", "sequence": "TTGGTGATTACATCAAAACAAAACTGGTTGTTGTCCTCACTCATGGGAAGCCTGCTCCTTGCAGGCTGCTCATTGGCCCCAGAATATCAACCTGCAAAAGTTATAGTGCCAGTCAAATTCAAAGAATCTGACCCCAAACTTGAAGATAATAACTGGAAGATTGCCCAACCTGCTGATCAGCAAACTCGTGGTGAATGGTGGCGCATTTACAATGATGCTCAACTGAATGAACTTGAACAGCAAGCTATCGCGGGCAACCAGAACCTAAAAGCGGTGGCAGCAAATATTCAGGCTTCACGTGCATTACGTTCGGCAGCTCAAGCTGAACGCTTACCAAGTATTGATGCCGGATTTGGGCCAACCCGCCAAAAGCCGTCTCCGGCTTCACTCGGTTTAGATGACAATGCACATACTTCGGCTCAAACCTTATGGCGAGCTCAAGCCAATGTTTCATATGAGCTCGATTTATTTGGTCGTGTAGCAAGTAGTGTCAACGCAGCAACAGCGGATCTACAGCAACAAGAGGCACTATATCAGTCGGCACTTTTAGCTCTACAAGCGGATGTAGCTCAAGGTTATTTTCTGATACGTCAACTTGATACCGAACAGGCAATTTATAACCGTACAATCAAATTATTAGGTGAAACACGAGATTTAATGCAGCTTCGTTTTAAAAACGGACTGGTCAGTGAATTAGATGTTTCTCGTGCACAAACCGAACTTGCTACCGCACAAACCACTGCCCTAAATATTGCTCGTAACAGAGCCAGTGCAGAACATGCGCTTGCAGTCTTATTAGGAAAACCACCAGCAGACTTTAACTTGGCAGTTCAACCTTTAACTGCAAATAGTATCCGTCTCCCTGCCGGTTTGCCGTCAACTTTACTTGAAAGACGACCCGATATTGCGGCTGCAGAGCGTGCAATGGCAGCAGATAATGCGCGTATTGGAATTGCTCGTGCAGCATTTTTCCCAAAACTCAGTCTTACAGGAGCTTTAGGTTATGAATCTTCAAGTTTAAGCGAGTTGGGTAAATGGTCGAGTCGGACTTTTTTACTAGGACCTGTCGCTGGTACTATTTTGTCGTTACCTTTATTTGATGGTGGACAACGTAAAGCAGGCGTTGCTCAAGCAAGAGCGGCTTATGAGGAAAGCGTCGCCAACTATAGACAAACTGTACTGAATGCATTTCGCGAAGTTGAAAATGGTTTATCTGATCAAAGAATTCTCGATCAGCAAATTCAGGCTCAAAACCAAGCACTCTCCTCTTCTCGTCATGCCAATCAACTTTCTCATTTACGTTATCGAGAAGGTGCTATTAGCTATCTTGATGTCATTGATTCTGACCGCACTATTTTGCAACAAGAACAATTAGCAGCTCAGCTGAAAGGCAGCCAAATCATTGCAAGCATCAATTTAATCCGTGCTTTAGGGGGCGGTTGGAGTAGTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii AYE", "NCBI_taxonomy_id": "509173", "NCBI_taxonomy_cvterm_id": "35535"}, "protein_sequence": {"accession": "CAJ77855.1", "sequence": "MVITSKQNWLLSSLMGSLLLAGCSLAPEYQPAKVIVPVKFKESDPKLEDNNWKIAQPADQQTRGEWWRIYNDAQLNELEQQAIAGNQNLKAVAANIQASRALRSAAQAERLPSIDAGFGPTRQKPSPASLGLDDNAHTSAQTLWRAQANVSYELDLFGRVASSVNAATADLQQQEALYQSALLALQADVAQGYFLIRQLDTEQAIYNRTIKLLGETRDLMQLRFKNGLVSELDVSRAQTELATAQTTALNIARNRASAEHALAVLLGKPPADFNLAVQPLTANSIRLPAGLPSTLLERRPDIAAAERAMAADNARIGIARAAFFPKLSLTGALGYESSSLSELGKWSSRTFLLGPVAGTILSLPLFDGGQRKAGVAQARAAYEESVANYRQTVLNAFREVENGLSDQRILDQQIQAQNQALSSSRHANQLSHLRYREGAISYLDVIDSDRTILQQEQLAAQLKGSQIIASINLIRALGGGWSS"}}}}}, "model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "900"}}}}}}, "2033": {"$update": {"model_sequences": {"$update": {"sequence": {"4254": {"dna_sequence": {"fmax": "1333499", "fmin": "1332866", "accession": "CP001050.1", "strand": "+", "sequence": "ATGAGAAAAACCAAAACCGAAGCCTTGAAAACCAAAGAACACCTGATGCTTGCCGCCTTGGAAACCTTTTACCGCAAAGGGATTGCCCGCACCTCGCTCAACGAAATCGCCCAAGCCGCCGGCGTAACGCGCGGCGCGCTCTATTGGCATTTCAAAAATAAGGAAGACTTGTTTGACGCGTTGTTCCAACGTATCTGCGACGACATCGAAAACTGCATCGCGCAAGATGCCGCAGATGCCGAAGGAGGTTCTTGGACGGTATTCCGCCACACGCTGCTGCACTTTTTCGAGCGGCTGCAAAGCAACGACATCTACTACAAATTCCACAACATCCTGTTTTTAAAATGCGAACACACGGAGCAAAACGCCGCCGTTATCGCCATTGCCCGCAAGCATCAGGCAATCTGGCGCGAGAAAATTACCGCCGTTTTGACCGAAGCGGTGGAAAATCAGGATTTGGCTGACGATTTGGACAAGGAAACGGCGGTCATCTTCATCAAATCGACGTTGGACGGGCTGATTTGGCGTTGGTTCTCTTCCGGCGAAAGTTTCGATTTGGGCAAAACCGCCCCGCGCATCATCGGGATAATGATGGACAACTTGGAAAACCATCCCTGCCTGCGCCGGAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae NCCP11945", "NCBI_taxonomy_id": "521006", "NCBI_taxonomy_cvterm_id": "37080"}, "protein_sequence": {"accession": "ACF30254.1", "sequence": "MRKTKTEALKTKEHLMLAALETFYRKGIARTSLNEIAQAAGVTRGALYWHFKNKEDLFDALFQRICDDIENCIAQDAADAEGGSWTVFRHTLLHFFERLQSNDIYYKFHNILFLKCEHTEQNAAVIAIARKHQAIWREKITAVLTEAVENQDLADDLDKETAVIFIKSTLDGLIWRWFSSGESFDLGKTAPRIIGIMMDNLENHPCLRRK"}}}}}}}, "2013": {"$update": {"model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "225"}}}}}}, "147": {"$update": {"model_sequences": {"$update": {"sequence": {"4236": {"dna_sequence": {"fmax": "937", "fmin": "115", "accession": "AF201828.2", "strand": "+", "sequence": "ATGAATAAATATTTTACTTGCTATGTGGTTGCTTCTCTTTTTCTTTCTGGTTGTACGGTTCAGCATAATTTAATAAATGAAACCCCGAGTCAGATTGTTCAAGGACATAATCAGGTGATTCATCAATACTTTGATGAAAAAAACACCTCAGGTGTGCTGGTCATTCAAACAGATAAAAAAATTAATCTATATGGTAATGCTCTAAGCCGCGCAAATACAGAATATGTGCCAGCCTCTACATTTAAAATGTTGAATGCCCTGATCGGATTGGAGAACCAGAAAGCGGATATTAATGAAATATTTAAATGGAAGGGCGAGAAAAGGTCATTTACCGCTTGGGAAAAAGACATGACACTAGGAGAAGCCATGAAGCTTTCTGCAGTCCCAGTCTATCAGGAACTTGCGCGACGTATCGGTCTTGATCTCATGCAAAAAGAAGTAAAACGTATTGGTTTCGGTAATGCTGAAATTGGACAGCAGGTTGATAATTTCTGGTTGGTAGGACCATTAAAGGTTACGCCTATTCAAGAGGTAGAGTTTGTTTCCCAATTAGCACATACACAGCTTCCATTTAGTGAAAAAGTGCAGGCTAATGTAAAAAATATGCTTCTTTTAGAAGAGAGTAATGGCTACAAAATTTTTGGAAAGACTGGTTGGGCAATGGATATAAAACCACAAGTGGGCTGGTTGACCGGCTGGGTTGAGCAGCCAGATGGAAAAATTGTCGCTTTTGCATTAAAAATGGAAATGCGGTCAGAAATGCCGGCATCTATACGTAATGAATTATTGATGAAATCATTAAAACAGCTGAATATTATTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "AAG35609.2", "sequence": "MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKADINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALKMEMRSEMPASIRNELLMKSLKQLNII"}}}}}}}, "1097": {"$update": {"model_sequences": {"$update": {"sequence": {"4238": {"dna_sequence": {"fmax": "1223", "fmin": "62", "accession": "AY154657.2", "strand": "+", "sequence": "GTGTCCACACCACATCACGGCCGGCACGAGCTCGGCCAGAACTTCCTGTCCGATCGGCGCGTCATCGCCGATATCGTCGAAATCGTCTCGCGCACAAACGGTCCGATCATCGAGATCGGGGCGGGCGACGGCGCGCTGACCATACCCTTGCAACGACTCGCCCGCCCGCTCACCGCCGTCGAGGTCGACGCGCGGCGCGCGCGGCGGTTGGCGCAGCGCACCGCGAGATCCGCCCCGGGGCCTGCCTCGCGGCCCACCGAGGTCGTCGCCGCCGACTTCCTGCGCTACCCACTGCCCCGCTCACCCCACGTGGTCGTGGGCAACCTGCCGTTCCACCTCACCACCGCGATCCTGCGGCGACTGCTGCACGGTCCGGGCTGGACCACGGCCGTGCTGCTCATGCAGTGGGAGGTGGCCCGCCGACGCGCCGCGGTGGGCGGCGCCACCATGATGACCGCCCAGTGGTGGCCGTGGTTCGAATTCGGCCTTGCCCGAAAGGTTTCCGCGGCGAGCTTCACGCCGCGGCCCGCGGTCGACGCCGGACTGCTCACCATCACGCGCCGCAGCCGGCCGCTGGTCGACGTCGCGGACCGGGCGCGTTACCAGGCGCTGGTGCACCGCGTGTTCACCGGACGCGGACACGGCATGGCGCAGATCCTGCAACGGTTGCCCACGCCGGTGCCCCGCACTTGGTTGCGGGCCAACGGGATAGCACCGAACTCCCTGCCCCGCCAGTTGTCCGCGGCGCAGTGGGCGGCGCTGTTCGAGCAGACGCGTCTAACTGGTGCCCAACGGGTCGATCGTCCACGCGATGTACAGCACGGCCGCGCTCACCGTCGCCGTGGTGGCGAAGTCGATCGCCCGGCTACGCACCACAAGCAGACCGGCCCGGTCGTCGGTCAGCGCCAACCGCAGCGCGGCCGCGACGCCGACGCCGATCCCGATGACCAGCGCACCGCGCCGCCAGTAACCCGCCACCACCAGGGCGAACGCCGCGATGAAGATCAGGCCGACCACCAGGATCGGCCATTGACCGGCGAACACCTTGCGGGCGAATTCCTTTGGCGTCACGCCAGTTTCGACTCTTCGGCTTCGACGACGTTGGTCAGCAGGAAGGCGCGGGTCAACGGGCCCACGCCACCGGGGTTGGGCGACACGTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium smegmatis", "NCBI_taxonomy_id": "1772", "NCBI_taxonomy_cvterm_id": "36871"}, "protein_sequence": {"accession": "AAN86837.2", "sequence": "MSTPHHGRHELGQNFLSDRRVIADIVEIVSRTNGPIIEIGAGDGALTIPLQRLARPLTAVEVDARRARRLAQRTARSAPGPASRPTEVVAADFLRYPLPRSPHVVVGNLPFHLTTAILRRLLHGPGWTTAVLLMQWEVARRRAAVGGATMMTAQWWPWFEFGLARKVSAASFTPRPAVDAGLLTITRRSRPLVDVADRARYQALVHRVFTGRGHGMAQILQRLPTPVPRTWLRANGIAPNSLPRQLSAAQWAALFEQTRLTGAQRVDRPRDVQHGRAHRRRGGEVDRPATHHKQTGPVVGQRQPQRGRDADADPDDQRTAPPVTRHHQGERRDEDQADHQDRPLTGEHLAGEFLWRHASFDSSASTTLVSRKARVNGPTPPGLGDT"}}}}}}}, "1313": {"$update": {"model_sequences": {"$update": {"sequence": {"4256": {"dna_sequence": {"fmax": "4629", "fmin": "3438", "accession": "AF370885.1", "strand": "+", "sequence": "ATGCAAAAGCATCTTTTACTTCCTTTATTTTTATCTATTGGGCTGATATTACAGGGGTGTGATTCAAAAGAAGTCGCTCAAGCTGAGCCACCACCGGCTAAAGTCAGTGTATTAAGCATTCAACCGCAATCGGTAAATTTTAGTGAAAATCTTCCTGCACGTGTACATGCATTCCGTACGGCGGAAATCCGTCCGCAAGTCGGAGGTATCATTGAAAAGGTTCTATTTAAACAAGGTAGTGAAGTTAGAGCAGGGCAAGCCTTATATAAAATTAATTCCGAGACTTTTGAGGCCGATGTAAATAGCAATAGAGCTTCTCTCAATAAAGCTGAAGCTGAGGTGGCAAGACTCAAAGTTCAGTTAGAACGTTATGAGCAGTTATTACCAAGTAATGCAATTAGTAAGCAAGAAGTAAGTAATGCTCAAGCTCAGTATCGTCAGGCTCTAGCCGATGTCGCTCAAATGAAAGCATTGCTGGCCAGACAAAACTTGAATCTGCAATATGCAACAGTTCGAGCGCCTATTTCTGGGCGTATTGGGCAATCTTTTGTCACTGAAGGTGCATTGGTCGGTCAGGGCGATACCAATACGATGGCAACCATTCAACAGATTGATAAAGTCTATGTTGATGTAAAGCAATCGGTTAGTGAGTATGAACGCCTACAGGCTGCGCTACAAAGCGGCGAATTATCAGCAAATAGTGACAAAACCGTTCGTATTACCAATAGCCACGGACAGCCCTATAACGTCACAGCAAAAATGTTGTTTGAAGATATTAATGTTGACCCGGAAACAGGCGATGTCACATTCCGTATTGAAGTTAATAACACTGAACGAAAATTACTTCCGGGCATGTATGTGCGTGTCAATATTGATCGTGCTTCTATTCCTCAAGCGCTATTGGTTCCGGCGCAAGCGATCCAACGTAATATCAGTGGCGAGCCTCAGGTATATGTCATTAACGCCCAAGGGACAGCGGAAATTCGTCCTATCGAAATTGGACAGCAATATGAGCAGTTCTATATCGCTAACAAAGGCTTGAAAGTCGGTGACAGAGTCGTTGTTGAAGGTATTGAACGTATTAAGCCAAATCAAAAATTGGCATTGGCAGCATGGAAAGCACCAGCCGTCGCGAATCATGCTTCAAGTGTAGAAACCAAAACTTCTATAGCTGAAGGGGCACAACCATGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "AAL14439.1", "sequence": "MQKHLLLPLFLSIGLILQGCDSKEVAQAEPPPAKVSVLSIQPQSVNFSENLPARVHAFRTAEIRPQVGGIIEKVLFKQGSEVRAGQALYKINSETFEADVNSNRASLNKAEAEVARLKVQLERYEQLLPSNAISKQEVSNAQAQYRQALADVAQMKALLARQNLNLQYATVRAPISGRIGQSFVTEGALVGQGDTNTMATIQQIDKVYVDVKQSVSEYERLQAALQSGELSANSDKTVRITNSHGQPYNVTAKMLFEDINVDPETGDVTFRIEVNNTERKLLPGMYVRVNIDRASIPQALLVPAQAIQRNISGEPQVYVINAQGTAEIRPIEIGQQYEQFYIANKGLKVGDRVVVEGIERIKPNQKLALAAWKAPAVANHASSVETKTSIAEGAQP"}}}}}}}, "896": {"$update": {"model_sequences": {"$update": {"sequence": {"4241": {"dna_sequence": {"fmax": "3406", "fmin": "2530", "accession": "JN969893.3", "strand": "+", "sequence": "ATGATGACTCAGAGCATTCGCCGCTCAATGTTAACGGTGATGGCGACGCTACCCCTGCTATTTAGCAGCGCAACGCTGCATGCGCAGGCGAACAGCGTGCAACAGCAGCTGGAAGCCCTGGAGAAAAGTTCGGGAGGTCGGCTTGGCGTTGCGCTGATTAACACCGCCGATAATTCGCAGATTCTCTACCGTGCCGATGAACGTTTTGCGATGTGCAGTACCAGTAAGGTGATGGCGGCCGCGGCGGTGCTTAAACAGAGCGAGAGCGATAAGCACCTGCTAAATCAGCGCGTTGAAATCAAGAAGAGCGACCTGGTTAACTACAATCCCATTGCGGAGAAACACGTTAACGGCACGATGACGCTGGCTGAGCTTGGCGCAGCGGCGCTGCAGTATAGCGACAATACTGCCATGAATAAGCTGATTGCCCATCTGGGTGGTCCCGATAAAGTGACGGCGTTTGCTCGCTCGTTGGGTGATGAGACCTTCCGTCTGGACAGAACCGAGCCCACGCTCAATACCGCCATTCCAGGCGACCCGCGTGATACCACCACGCCGCTCGCGATGGCGCAGACCCTGAAAAATCTGACGCTGGGTAAAGCGCTGGCGGAAACTCAGCGGGCACAGTTGGTGACGTGGCTTAAGGGCAATACTACCGGTAGCGCGAGCATTCGGGCGGGTCTGCCGAAATCATGGGTAGTGGGCGATAAAACCGGCAGCGGAGGTTATGGCACCACCAACGATATCGCGGTTATCTGGCCGGAAAACCACGCACCGCTGGTTCTGGTGACCTACTTTACCCAACCGGAGCAGAAGGCGGAAAGCCGTCGGGATATTCTGGCTGCGGCGGCGAAAATCGTAACCCACGGTTTCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Providencia rettgeri", "NCBI_taxonomy_id": "587", "NCBI_taxonomy_cvterm_id": "36944"}, "protein_sequence": {"accession": "AEW46676.3", "sequence": "MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGGYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF"}}}}}}}, "1233": {"$update": {"model_sequences": {"$update": {"sequence": {"4245": {"dna_sequence": {"fmax": "2083", "fmin": "163", "accession": "AJ295238.3", "strand": "+", "sequence": "ATGAAAATAATTAACTTAGGCATTCTGGCTCACGTTGACGCAGGAAAGACAACATTAACGGAAAGTTTATTGTATACCAGTGGTGCAATTGCAGAACTAGGGAGCGTAGATGAAGGCACAACAAGGACAGATACAATGAATTTGGAGCGTCAAAGGGGAATCACTATCCAGACAGCAGTGACATCTTTTCAGTGGGAGGATGTAAAAGTCAACATTATAGATACGCCAGGCCATATGGATTTTTTAACCGAAGCATACCGCTCTTTATCTGTCCTTGACGGAGCTGTTTTAGTCATTTCGGCAAAAGACGGCGTACAGGCACAGACGCGTATATTATTCCATGCGCTTCAGAAAATGAACATTCCGACAATTATCTTTATAAATAAGATAGACCAAAATGGAATCGACCTACAGCGTGTTTACCAAAGCATTAAAGACAAACTTACCAGTGATATGATTGTCATGCAGGAGGTTTCCCTGTCGCCAAAGATAACCATGACCGATATTTCTGATTTGGACAAATGGGATATGATTATTTCCGGAAGCGATGAACTATTAGAACGATATGTTGCAGAGGATTCTTTGGATATACAGGAATTACAATATGAAAAGTGCAAAAGAACCAGATGCTGCTCTTTGTTTCCTGTTTATCATGGGAGTGCAAAAGACAATTTAGGAACAGAAAAACTGATTGAAGCGATTACAGAAACTTTCATTACAGAAACAGACGATATTCAGTCTGAATTATGTGGATATGTTTTTAAGGTTGAGTATACAGAGCGGAAAAAACGGCTTTCTTATTTACGCCTGTATCATGGGACGCTCCATTTACGGGATACCCTGCTGCTGTCAAAAAAGGAAAAAATAAAGATTACAGAAATGTGTATTCCGTCAAATGGTGAAATCGTCCCGGTTGACCATGCCTGTCCGGGAGAAATTGTTATTTTAGCTGATGATACTTTGAAACTGAACGACATTCTGGGAAATGAAAAACTCCTGCCTCACAAAACACGGATTGATAATCCCATGCCATTACTTCGGACAACGGTAGAGCCGCAAAAGCCGGAGCAAAGGGAAGCCCTGTTAAATGCCCTCACAGAGATTGCTGATACAGACCCTCTTTTGCATTTTGACATTGATACTGTTACACATGAGATTATATTATCTTTTTTGGGAAAAGTACAGTTAGAAGTTATTTGTTCGCTATTAGAAGAAAAATATCATGTGGGCGTGGCTATGAAAGAGCCTTCGGTTATTTATCTGGAAAGACCGCTTAGAAAAGCAGAATATACCATCCACATAGAAGTCCCGCCAAATCCTTTCTGGGCTTCTGTCGGGTTGTCCATAGAGCCGCTCCCTATTGGAAGCGGAGTGCAGTATGAAAGCAGAGTTTCACTTGGATATTTAAATCAATCGTTCCAAAATGCGGTTATGGAGGGGGTTCTTTATGGCTGCGAGCAGGGGCTGTATGGATGGAAAGTGACAGACTGTAAAATCTGTTTTGAATATGGATTGTATTATAGTCCTGTAAGTACCCCCGCAGACTTTCGGCTGCTTTCCCCTATCGTATTGGAGCAGGCTTTAAAAAAAGCAGGGACAGAACTATTAGAGCCATATCTCCACTTTGAAATTTATGCACCGCAGGAATATCTCTCACGGGCGTATCATGATGCTCCAAGGTATTGTGCAGATATTGTAAGTACTCAGATAAAGAATGACGAGGTCATTCTGAAAGGAGAAATCCCTGCTAGATGTATTCAAGAATACAGGAACGATTTAACTTATTTCACAAATGGGCAGGGAGTCTGCTTGACAGAGTTAAAAGGATACCAGCCAGCTATTGGTAAATTTATTTGCCAACCCCGCCGCCCGAATAGCCGTATAGATAAGGTTCGGCATATGTTCCACAAGTTAGCTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Clostridiaceae bacterium K10", "NCBI_taxonomy_id": "185309", "NCBI_taxonomy_cvterm_id": "36797"}, "protein_sequence": {"accession": "CAC41371.2", "sequence": "MKIINLGILAHVDAGKTTLTESLLYTSGAIAELGSVDEGTTRTDTMNLERQRGITIQTAVTSFQWEDVKVNIIDTPGHMDFLTEAYRSLSVLDGAVLVISAKDGVQAQTRILFHALQKMNIPTIIFINKIDQNGIDLQRVYQSIKDKLTSDMIVMQEVSLSPKITMTDISDLDKWDMIISGSDELLERYVAEDSLDIQELQYEKCKRTRCCSLFPVYHGSAKDNLGTEKLIEAITETFITETDDIQSELCGYVFKVEYTERKKRLSYLRLYHGTLHLRDTLLLSKKEKIKITEMCIPSNGEIVPVDHACPGEIVILADDTLKLNDILGNEKLLPHKTRIDNPMPLLRTTVEPQKPEQREALLNALTEIADTDPLLHFDIDTVTHEIILSFLGKVQLEVICSLLEEKYHVGVAMKEPSVIYLERPLRKAEYTIHIEVPPNPFWASVGLSIEPLPIGSGVQYESRVSLGYLNQSFQNAVMEGVLYGCEQGLYGWKVTDCKICFEYGLYYSPVSTPADFRLLSPIVLEQALKKAGTELLEPYLHFEIYAPQEYLSRAYHDAPRYCADIVSTQIKNDEVILKGEIPARCIQEYRNDLTYFTNGQGVCLTELKGYQPAIGKFICQPRRPNSRIDKVRHMFHKLA"}}}}}}}, "260": {"$update": {"model_sequences": {"$update": {"sequence": {"4244": {"dna_sequence": {"fmax": "1035", "fmin": "159", "accession": "X97721.2", "strand": "+", "sequence": "ATGCCGTCCCGGCCACGTACCGATTCGCCCCACCGGCACGAGGGGCCGGCCGGCCCGGCCCGTCTCGACCGGGACGAGGCCCGCCGTGTATGGGGCCAGAATTTCTTCCGCTCGGCGGGTTCGGCCCGCCGTTTCGCCCGGCAGTTGACCGGCGCGGAATCGGCCGGAAACGACTCGGTCACCGTCGAGGTGGGTCCCGGGGCCGGCCGTATCACCAAGGAGTTAGTGAGGGACGGTCATCCGATCGTCGCGGTGGAGGTGGACCCCCATTGGGCCGACCGCCTCGCCGAACTGGAACTGCCGAACCTCACCGTCGTCAACGACGACTTCACGACCTGGCCGCTGCCCGACGGGCCGCTGCGGTTCATCGGCAATCTGCCCTTCGGCACCGGCACCAGGATGCTCCGCCGCTGCCTCGCCCTCGGCCCGGACCGCTGCCGCGAAGGCGTGTTCCTTCTCCAGAAGCAGTACACGCGCAAGCGCACCGGTGCCTACGGCGGCAATCTCTTCAACGCCCAGTGGGAGCCCTGGTACACGTTCCGCCGCGGACTGGGCTTCCCCCGGCAGGAGTTCGCCCCGGTCCCGGGCTCCGACACCGAGACCCTGCTGGTGAGATCGCGCCCGCGCCCGCTGGCGCCCTGGTCCCGCCATGCCGCCTACCAGCGGTTCGTGGAGGACGTGTTCAACACCTCCCGGCTCACCATCGGTGAGGCCGCCCGCGCGCTGGACCGCCGGGCCGGCCCGGGCTGGCTCCGGGGCGCGCGGGTGCCTCCCGGGTTGCGGGTCAAGGACATCACGGCCGAGCAGTGGGCCGATCTCTTCCACGCGTGCACCCCGCCGCCCGCCCGGCGCATCTCGCCGCAGCGGAGGCGCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces fradiae", "NCBI_taxonomy_id": "1906", "NCBI_taxonomy_cvterm_id": "36838"}, "protein_sequence": {"accession": "CAA66307.2", "sequence": "MPSRPRTDSPHRHEGPAGPARLDRDEARRVWGQNFFRSAGSARRFARQLTGAESAGNDSVTVEVGPGAGRITKELVRDGHPIVAVEVDPHWADRLAELELPNLTVVNDDFTTWPLPDGPLRFIGNLPFGTGTRMLRRCLALGPDRCREGVFLLQKQYTRKRTGAYGGNLFNAQWEPWYTFRRGLGFPRQEFAPVPGSDTETLLVRSRPRPLAPWSRHAAYQRFVEDVFNTSRLTIGEAARALDRRAGPGWLRGARVPPGLRVKDITAEQWADLFHACTPPPARRISPQRRR"}}}}}}}, "489": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["2662"]}, "clinical": {"$delete": ["2662"]}}}}}}}, "100": {"$update": {"model_param": {"$insert": {"41339": {"param_value": {"8312": "ntT-11C"}, "param_type_id": "41339", "param_type": "mutation in regulatory element", "param_description": "An AMR detection model parameter to describe mutations in regulatory elements upstream of a coding DNA region shown to confer resistance to an antibiotic drug or drug class. Regulatory element mutations in CARD use the following notation: nt[wild-type][-][position][mutation]."}}}}}, "2046": {"$update": {"model_sequences": {"$update": {"sequence": {"4246": {"dna_sequence": {"fmax": "24163", "fmin": "22939", "accession": "AJ420072.1", "strand": "+", "sequence": "GTGTCATCTCTCACTTCCGCTCGTGGCTCGTTGGCCACGGTCCTCATCACGGCTAGCCTCGACGCCGCCGGCATGGGCCTGGTGATGCCGATTCTTCCCGCACTGCTACACGAGGCAGGGGTCACCGCTGATGCGGTTCCGCTGAACGTCGGAGTGCTGATCGCGCTCTACGCGGTAATGCAGTTCATCTTTGCCCCCGTACTGGGAACGCTGTCGGACCGATTCGGCCGCCGCCGGGTGCTGCTTGTTTCCCTGGCCGGTGCGACCGTCGACTATCTCGTGCTCGCCACGACGTCCGCTCTGTCGGTGTTCTATATCGCCCGCGCAGTGGCTGGGATAACCGGAGCGACCAATGCGGTCACCGCCACCGTGATCGCCGACATCACGCCACCCCACCAGCGCGCCAAGCGTTTCGGTTTACTCAGTGCCTGCTATGGCGGCGGAATGATCGCGGGGCCAGCCATGGGTGGACTGTTCGGTGCCATCTCGCCACATCTGCCGTTTTTGCTCGCTGCTCTTCTCTCAGCGAGCAATCTGGCACTCACCTTTATCCTGTTACGCGAGACCCGTCCTGATTCCCCTGCGCGCTCTGCGTCGCTCGCTCAGCATCGTGGTCGCCCCGGCCTCAGCGCGGTGCCTGGGATTACCTTCCTATTAATCGCATTCGGCCTTGTTCAATTCATTGGGCAGGCTCCAGGTGCGACCTGGGTGCTGTTTACTGAACACCGCCTCGACTGGAGTCCCGTCGAAGTTGGAATCTCCCTGTCCGTTTTCGGGATCGTACAGGTTCTCGTGCAGGCCCTCCTTACTGGCCGCATCGTGGAGTGGATCGGTGAGGCAAAAACAGTCATCATCGGGTGTATTACCGACGCCTTGGGTCTCGTAGGCCTGGCGATTGTCACTGACGCATTTTCCATGGCACCTATCTTGGCGGCACTGGGGATCGGTGGCATCGGCCTCCCCGCTCTGCAAACCCTTCTCTCCCAGCGCGTCGATGAACAGCACCAAGGGCGCCTCCAGGGTGTGCTCGCCAGCATCAACAGCGTCACATCGATCTTCGGACCGGTCGCTTTCACAACGATCTTCGCGCTCACTTACATCAACGCCGACGGCTTCCTCTGGCTCTGCGCCGCAGCACTCTACGTGCCCTGCGTGATTCTCATCATGCGTGGTACAGCAGCGTCCCCGAAGTTCGGCTCTTGGGCGAGCGGCGACTCGATGTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Corynebacterium glutamicum", "NCBI_taxonomy_id": "1718", "NCBI_taxonomy_cvterm_id": "36777"}, "protein_sequence": {"accession": "CAD12227.2", "sequence": "MSSLTSARGSLATVLITASLDAAGMGLVMPILPALLHEAGVTADAVPLNVGVLIALYAVMQFIFAPVLGTLSDRFGRRRVLLVSLAGATVDYLVLATTSALSVFYIARAVAGITGATNAVTATVIADITPPHQRAKRFGLLSACYGGGMIAGPAMGGLFGAISPHLPFLLAALLSASNLALTFILLRETRPDSPARSASLAQHRGRPGLSAVPGITFLLIAFGLVQFIGQAPGATWVLFTEHRLDWSPVEVGISLSVFGIVQVLVQALLTGRIVEWIGEAKTVIIGCITDALGLVGLAIVTDAFSMAPILAALGIGGIGLPALQTLLSQRVDEQHQGRLQGVLASINSVTSIFGPVAFTTIFALTYINADGFLWLCAAALYVPCVILIMRGTAASPKFGSWASGDSM"}}}}}}}, "1434": {"$update": {"model_sequences": {"$update": {"sequence": {"4237": {"dna_sequence": {"fmax": "833", "fmin": "32", "accession": "AF319779.2", "strand": "+", "sequence": "ATGACAAAAAAGAAATTGCCCGTTCGTTTTACGGGTCAGCACTTTACTATTGACAAAGTGCTTATTAAAGATGCAATAAAAGAATCAAATATAAATCAACACGATACAGTTTTAGATATTGGAGCTGGTAAGGGTTTTCTAACTGTTCATCTCTTAAAAAATGTCGATAAAGTTATTGCCATTGAAAACGATGTTGCATTAAGTCAACATTTGCGCAAAAAATTCATTCACGCTCAAAACGTTCAAGTGGTTAGTTGTGATTATAGAAATTTTGTGGTTCCGAAAGTTCCATTTAAAGTAGTTTCAAATATTCCTTTTGGTATTACATCTGATATTTTTAGTAGTCTGATGTTTGAAAATGTCGAATATTTTCTATGCGGTTCAATTATCCTTCAGTCAGAACCGGCAAAAAAATTGTTTTCAAGTAAGGTTTATAACCCATTGACAGTACTTTATCATACCTATTATGATTTGAAATTCCTGTATGAGATAAATCCTGAAAGTTTTTTGCCACCACCAACTGTCAAATCAGCACTTTTGAGAATTGAAAGAAAACAGATTTCATTAGATATTGGGCTTAAGGTTAAGTACTTAAATTTTGTTTCGTATATGTTACAAAAACCTGATTTAACAGTCAAAACAGCTATGAAGTCTATTTTTAGAAAAAAACAAGTTAGGTCAATTTCAGAAAAATTTGGAGTTGACCTTAACTCCAAAATTGTCTGTTTGACTCCAAATCAATGGAAGAATTGTTTTTTAGAAATGCTCGAAGTTGTTCCTGAAAAGTTTCATCCGTCATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacteroides coprosuis DSM 18011", "NCBI_taxonomy_id": "679937", "NCBI_taxonomy_cvterm_id": "36798"}, "protein_sequence": {"accession": "AAK07612.2", "sequence": "MTKKKLPVRFTGQHFTIDKVLIKDAIKESNINQHDTVLDIGAGKGFLTVHLLKNVDKVIAIENDVALSQHLRKKFIHAQNVQVVSCDYRNFVVPKVPFKVVSNIPFGITSDIFSSLMFENVEYFLCGSIILQSEPAKKLFSSKVYNPLTVLYHTYYDLKFLYEINPESFLPPPTVKSALLRIERKQISLDIGLKVKYLNFVSYMLQKPDLTVKTAMKSIFRKKQVRSISEKFGVDLNSKIVCLTPNQWKNCFLEMLEVVPEKFHPS"}}}}}}}, "_timestamp": "2018-04-12T18:42:39+00:00", "948": {"$update": {"model_sequences": {"$update": {"sequence": {"4247": {"dna_sequence": {"fmax": "49265", "fmin": "48893", "accession": "BA000018.3", "strand": "+", "sequence": "ATGGATAATAAAACGTATGAAATATCATCTGCAGAATGGGAAGTTATGAATATCATTTGGATGAAAAAATATGCAAGTGCGAATAATATAATAGAAGAAATACAAATGCAAAAGGACTGGAGTCCAAAAACCATTCGTACACTTATAACGAGATTGTATAAAAAGGGATTTATAGATCGTAAAAAAGACAATAAAATTTTTCAATATTACTCTCTTGTAGAAGAAAGTGATATAAAATATAAAACATCTAAAAACTTTATCAATAAAGTATACAAAGGCGGTTTCAATTCACTTGTCTTAAACTTTGTAGAAAAAGAAGATCTATCACAAGATGAAATAGAAGAATTGAGAAATATATTGAATAAAAAATAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus subsp. aureus N315", "NCBI_taxonomy_id": "158879", "NCBI_taxonomy_cvterm_id": "35514"}, "protein_sequence": {"accession": "BAB41258.1", "sequence": "MDNKTYEISSAEWEVMNIIWMKKYASANNIIEEIQMQKDWSPKTIRTLITRLYKKGFIDRKKDNKIFQYYSLVEESDIKYKTSKNFINKVYKGGFNSLVLNFVEKEDLSQDEIEELRNILNKK"}}}}}}}, "1642": {"$update": {"model_sequences": {"$update": {"sequence": {"4249": {"dna_sequence": {"fmax": "1163470", "fmin": "1162417", "accession": "AP006627.1", "strand": "+", "sequence": "ATGAAAGTTGTCAATCATGCGACAAAATACGAACGATTAAAACATTTTTTGAATGCTTTAAATGAACCAACGTACCGGTATAAACAGATTACTGAAGCGATTTTCAAACATCGTATTGGTGCGTTTAATAAAATGACCACATTGCCAAAAGCACTGAGAGAATCGCTCATAAACGAATTTGGTCCTTCCATCCTTACAGTAGAGCCGGTGCTAGAAACAACGTCTCAACAAGTCACTAAAGTGTTGCTAAAAGTAGCGGGAAACAATCAAGTGGAAGCCGTAAGAATGCATTATGAAGCAGGGTGGGAGTCGTTTTGCATTTCTTCTCAATGTGGCTGTGGGTTAGGGTGTACGTTTTGTTCGACAGGAGCCATTGGGTTAAAACAAAACTTATCAGCAGACGAGATGACAGACCAGTTGCTCTATTTTTATCTGAAGGGGCATTCCTTAGATAGTGTCTCTTTTATGGGCATGGGCGAAGCGCTAGCCAATGTAAGGATATTTGATGCTTTGAATGTGCTTGTCGATCGGCAACTATTTGCATTAAGTCCTAGAAGAATAACGGTCTCTACGGTTGGCATCATACCAAACATCCAAAGAATGACTAGCAGCTTTCCTCAGATGAACCTAACGTTTTCACTGCACTCTCCTTTTCATGATCAGCGCAGCGAGTTGATGCCGATTAACAACAAGTACCCGTTAGACCAGGTAATGAATGTATTGGATCAGCATATTCACGAGACAGGGAGAAAAGTATATATTGCTTATGTCATGCTTCGGGGTGTCAATGATTCGGAGAAACATGCAGAAGCACTTGTTAAACGGATTCTAAACAATCGCTATCCCCATCTCTATCATGTCAATTTGATTCGCTACAATCCGACTGTGGGTACGCCTGAAAACTATGGCCAAACCATAGAAGAGAAACTGCAAACTTTTTACCGTGTCGTAAAATCAGCTCGAATTCCTGTAACGATTCGGAGTCAATTTGGAAGAGAAATTGATGCCGCCTGCGGCCAATTATATGGTCAGTATCAGGCGAAAAAAAGGTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacillus clausii KSM-K16", "NCBI_taxonomy_id": "66692", "NCBI_taxonomy_cvterm_id": "39605"}, "protein_sequence": {"accession": "BAD63613.1", "sequence": "MKVVNHATKYERLKHFLNALNEPTYRYKQITEAIFKHRIGAFNKMTTLPKALRESLINEFGPSILTVEPVLETTSQQVTKVLLKVAGNNQVEAVRMHYEAGWESFCISSQCGCGLGCTFCSTGAIGLKQNLSADEMTDQLLYFYLKGHSLDSVSFMGMGEALANVRIFDALNVLVDRQLFALSPRRITVSTVGIIPNIQRMTSSFPQMNLTFSLHSPFHDQRSELMPINNKYPLDQVMNVLDQHIHETGRKVYIAYVMLRGVNDSEKHAEALVKRILNNRYPHLYHVNLIRYNPTVGTPENYGQTIEEKLQTFYRVVKSARIPVTIRSQFGREIDAACGQLYGQYQAKKR"}}}}}}}, "1820": {"$update": {"ARO_category": {"$update": {"39982": {"$update": {"category_aro_name": "undecaprenyl pyrophosphate related proteins"}}}}}}, "866": {"$update": {"model_sequences": {"$update": {"sequence": {"4257": {"dna_sequence": {"fmax": "7736", "fmin": "4628", "accession": "AF370885.1", "strand": "+", "sequence": "ATGTCACAATTTTTTATTCGTCGTCCCGTTTTTGCTTGGGTTATTGCGATCTTCATTATTATATTTGGATTGCTGAGCATTCCTAAACTGCCAATTGCACGTTTTCCAAGTGTGGCCCCGCCACAGGTGAATATTAGTGCGACTTATCCTGGTGCTACAGCTAAAACCATTAACGATAGCGTTGTAACCTTAATTGAGCGCGAATTATCGGGTGTAAAAAATCTACTCTACTATAGTGCGACAACAGATACCTCCGGTACAGCAGAGATTACGGCTACGTTTAAACCAGGCACAGATGTGGAAATGGCTCAGGTTGACGTTCAAAATAAAATCAAGGCTGTAGAAGCTCGCTTACCGCAAGTTGTACGTCAGCAAGGTTTACAGGTTGAGGCTTCATCGTCCGGATTTTTAATGCTGGTCGGGATTAACTCTCCAAATAATCAATATTCCGAAGTTGATTTGAGTGATTATTTGGTTCGAAATGTTGTAGAAGAGCTAAAACGTGTCGAAGGTGTAGGGAAGGTTCAATCTTTCGGTGCCGAGAAAGCTATGCGTATTTGGGTCGACCCGAATAAGCTTGTTTCTTACGGTTTATCGATTAGTGATGTGAATAATGCCATTCGTGAAAATAATGTCGAAATTGCACCCGGCCGACTTGGTGATTTACCAGCTGAAAAAGGCCAGCTCATTACTATTCCATTGTCTGCTCAAGGGCAATTGTCTAGTCTCGAGCAATTTAAAAATATTAGCTTAAAAAGTAAAACTAACGGTAGCGTAATTAAGTTATCTGATGTTGCCAATGTAGAAATAGGCTCACAGGCATATAACTTTGCCATTTTGGAAAATGGTAAGCCTGCTACCGCGGCAGCAATTCAATTAAGCCCGGGTGCTAACGCCGTGAAAACTGCCGAAGTTGTTCGAGCAAAAATTGAAGAGTTGAAGCTAAATTTACCGGAAGGCATGGAGTTTAGTATTCCTTACGACACCGCGCCGTTTGTCAAAATTTCAATTGAAAAGGTAATTCATACATTACTTGAAGCCATGGTTCTGGTTTTCATTGTGATGTATCTATTTTTACATAATGTCCGCTATACGCTTATTCCAGCGATTGTGGCGCCTATTGCCTTACTCGGTACTTTTACCGTGATGTTGCTTGCCGGCTTTTCAATTAACGTACTCACCATGTTCGGTATGGTGCTTGCCATCGGGATTATTGTCGACGATGCCATTGTCGTGGTTGAAAACGTCGAAAGGATTATGGCGACAGAAGGATTATCGCCTAAAGATGCAACCTCTAAAGCAATGAAAGAGATTACCAGCCCGATTATTGGTATTACGCTGGTATTGGCGGCAGTATTTTTACCTATGGCATTTGCGAGTGGTTCTGTAGGGGTAATCTATAAACAGTTTACCTTGACCATGTCGGTATCTATTTTATTTTCAGCGCTATTGGCACTTATTTTAACACCGGCACTTTGTGCCACGATTTTAAAACCAATCGATGGGCATCACCAGAAGAAGGGCTTCTTTGCATGGTTTGACCGTAGTTTCGATAAAGTCACTAAAAAGTATGAATTGATGCTGCTTAAAATCATCAAACATACAGTTCCAATGATGGTGATCTTTTTAGTAATTACCGGTATTACCTTTACCGGAATGAAATATTGGCCAACAGCATTTATGCCAGAGGAAGATCAAGGTTGGTTCATGACTTCGTTCCAGCTACCTTCAGATGCAACCGCTGAGCGTACTCGGAATGTAGTCAATCAATTTGAAAATAATTTGAAAGACAATCCCGATGTAAAAAGTAATACCACCATTTTGGGATGGGGTTTTAGTGGCGCAGGACAAAATGTAGCTGTGGCTTTTACGACACTTAAAGACTTCAAAGAGCGGACTAGCTCTGCATCTAAGATGACAAGCGACGTTAATTCTTCTATGGCGAACAGTACGGAAGGCGAGACTATGGCCGTGTTACCACCCGCTATTGATGAGTTAGGTACTTTTTCAGGTTTCAGTTTACGTTTACAAGACCGCGCTAACTTAGGTATGCCTGCTTTACTGGCTGCTCAAGATGAACTTATGGCAATGGCAGCCAAGAATAAAAAGTTCTATATGGTTTGGAATGAAGGGTTGCCACAAGGTGACAATATTTCTTTAAAAATTGACCGTGAAAAGCTTAGTGCATTTGGTGTTAAGTTTTCTGATGTTTCAGACATCATTTCTACATCAATGGGTTCAATGTATATCAATGACTTCCCTAATCAAGGACGTATGCAACAAGTCATTGTACAGGTTGAGGCTAAATCACGTATGCAATTGAAAGATATCTTGAATCTGAAAGTCATGGGTTCAAGCGGTCAATTAGTCTCGTTATCAGAAGTTGTAACGCCACAATGGAATAAGGCACCACAACAATATAATCGTTATAACGGACGACCATCTTTGAGTATTGCTGGTATTCCTAACTTCGATACGTCATCGGGTGAAGCAATGCGTGAAATGGAACAACTGATTGCGAAATTACCGAAAGGTATTGGCTACGAGTGGACAGGTATTTCCTTACAGGAAAAGCAGTCTGAATCACAAATGGCCTTTTTACTTGGTTTATCCATGTTAGTTGTCTTCCTTGTCTTGGCTGCACTCTATGAAAGCTGGGCAATTCCACTTTCTGTGATGCTAGTTGTGCCACTCGGTATTTTTGGAGCAATCATTGCCATTATGTCTAGGGGGTTAATGAATGATGTGTTCTTCAAAATCGGGCTAATTACCATTATTGGTCTATCGGCAAAGAATGCGATTTTGATTGTTGAATTTGCGAAAATGCTGAAAGAAGAAGGCATGAGTTTGATTGAAGCCACTGTTGCCGCAGCCAAACTTCGCTTACGGCCAATTCTGATGACATCACTTGCATTTACGTGTGGTGTAATTCCTTTGGTGATTGCCTCAGGTGCAAGTTCAGAAACTCAACATGCTTTAGGCACAGGGGTTTTTGGCGGCATGATTTCAGCCACCATTCTGGCTATTTTCTTTGTTCCCGTGTTTTTTATCTTCATTTTGGGTGCAGTAGAAAAGCTATTTTCCTCTAAGAAAAAAATCTCATCTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "AAL14440.1", "sequence": "MSQFFIRRPVFAWVIAIFIIIFGLLSIPKLPIARFPSVAPPQVNISATYPGATAKTINDSVVTLIERELSGVKNLLYYSATTDTSGTAEITATFKPGTDVEMAQVDVQNKIKAVEARLPQVVRQQGLQVEASSSGFLMLVGINSPNNQYSEVDLSDYLVRNVVEELKRVEGVGKVQSFGAEKAMRIWVDPNKLVSYGLSISDVNNAIRENNVEIAPGRLGDLPAEKGQLITIPLSAQGQLSSLEQFKNISLKSKTNGSVIKLSDVANVEIGSQAYNFAILENGKPATAAAIQLSPGANAVKTAEVVRAKIEELKLNLPEGMEFSIPYDTAPFVKISIEKVIHTLLEAMVLVFIVMYLFLHNVRYTLIPAIVAPIALLGTFTVMLLAGFSINVLTMFGMVLAIGIIVDDAIVVVENVERIMATEGLSPKDATSKAMKEITSPIIGITLVLAAVFLPMAFASGSVGVIYKQFTLTMSVSILFSALLALILTPALCATILKPIDGHHQKKGFFAWFDRSFDKVTKKYELMLLKIIKHTVPMMVIFLVITGITFTGMKYWPTAFMPEEDQGWFMTSFQLPSDATAERTRNVVNQFENNLKDNPDVKSNTTILGWGFSGAGQNVAVAFTTLKDFKERTSSASKMTSDVNSSMANSTEGETMAVLPPAIDELGTFSGFSLRLQDRANLGMPALLAAQDELMAMAAKNKKFYMVWNEGLPQGDNISLKIDREKLSAFGVKFSDVSDIISTSMGSMYINDFPNQGRMQQVIVQVEAKSRMQLKDILNLKVMGSSGQLVSLSEVVTPQWNKAPQQYNRYNGRPSLSIAGIPNFDTSSGEAMREMEQLIAKLPKGIGYEWTGISLQEKQSESQMAFLLGLSMLVVFLVLAALYESWAIPLSVMLVVPLGIFGAIIAIMSRGLMNDVFFKIGLITIIGLSAKNAILIVEFAKMLKEEGMSLIEATVAAAKLRLRPILMTSLAFTCGVIPLVIASGASSETQHALGTGVFGGMISATILAIFFVPVFFIFILGAVEKLFSSKKKISS"}}}}}}}, "726": {"$update": {"model_sequences": {"$update": {"sequence": {"4250": {"dna_sequence": {"fmax": "10528", "fmin": "9682", "accession": "CP000732.1", "strand": "-", "sequence": "TTAAAATTCCTTCATTACACTCTTGGCGGTTTCACTTATCAACTTATCATTTGGCTTATCACTTTTATTGTCTTTATTCGTAAAAATGACTAAAACAATAGGTTCAGATTGGCCCTTAGGATAAACAAAAGCAACATCATTTCTAGAAGCATATGTTATTGCTTGACCACTTTTATCAGCAACTTTATAGTCTTTTGGAATACCATCTTTAATTAAAGTGTCTCCGTTTTTATTATTTAACATTAAATCAAGTAAGAAATTTTTATTTTTTTTGCTTAATTTTCCATTTGCGATAAGTTTATTTAAAGTCTTGCCGAAAGCAGCAGGCGTTGAAGTATCTTTTTTGCTCTTTGGTGAATAGTAATTTAATTCTATTTCATATCTAACTGGATTTGTTACTTTATCTCCCAATTTTTTTAAACGTTTTTTAATTTTTTTGATTCCACCGATTTCGTTTATAATTTTATTGTTTGCTGTATTATCACTGTACTTCATTGAAGCCTCAATAAGTTCTTTTAAAGCGATATCTTTTCCTACATATTTTTCTAAAATAGGAGAATAAGCAACTATATCATCTTTGTTAATATGTACTTTTTTATTTAACTTATTATAAGGTACTTGTTCTAACAAAATAGCACTATTTATCGCTTTTGAAGTCGAAGCATAGGCAAATCTCTTATCTGAATTAAATTTTACTTCCTTACCACTTTTAGTATCTAAAGCATAAACACCAATATGAGCATTATATTTTTTTTCTAAATCATTTAACTCTTTGGCATGTGAACTGTTTGAATTACATGCACTTAAAACTAAAGCAATTACAATTAAAAATATTAACTTTTTCAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus subsp. aureus USA300_TCH959", "NCBI_taxonomy_id": "450394", "NCBI_taxonomy_cvterm_id": "35526"}, "protein_sequence": {"accession": "ABX30738.1", "sequence": "MKKLIFLIVIALVLSACNSNSSHAKELNDLEKKYNAHIGVYALDTKSGKEVKFNSDKRFAYASTSKAINSAILLEQVPYNKLNKKVHINKDDIVAYSPILEKYVGKDIALKELIEASMKYSDNTANNKIINEIGGIKKIKKRLKKLGDKVTNPVRYEIELNYYSPKSKKDTSTPAAFGKTLNKLIANGKLSKKNKNFLLDLMLNNKNGDTLIKDGIPKDYKVADKSGQAITYASRNDVAFVYPKGQSEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF"}}}}}}}, "1367": {"$update": {"model_sequences": {"$update": {"sequence": {"4240": {"dna_sequence": {"fmax": "1248", "fmin": "0", "accession": "DQ195536.2", "strand": "+", "sequence": "ATGACCACCCAGACCACTCCCGCCCACATCGCCATGTTCTCCATCGCCGCCCACGGCCATGTGAACCCCAGCCTGGAGGTGATCCGTGAACTCGTCGCCCGCGGCCACCGGGTCACGTACGCCATTCCGCCCGTCTTCGCCGACAAGGTGGCCGCCACCGGCGCCCGGCCCGTCCTCTACCACTCCACCCTGCCCGGCCCCGACGCCGACCCGGAGGCATGGGGAAGCACCCTGCTGGACAACGTCGAACCGTTCCTGAACGACGCGATCCAGGCGCTCCCGCAGCTCGCCGATGCCTACGCCGACGACATCCCCGATCTCGTCCTGCACGACATCACCTCCTACCCGGCCCGCGTCCTGGCCCGCCGCTGGGGCGTCCCGGCGGTCTCCCTCTCCCCGAACCTCGTCGCCTGGAAGGGTTACGAGGAGGAGGTCGCCGAGCCGATGTGGCGCGAACCCCGGCAGACCGAGCGCGGACGGGCCTACTACGCCCGGTTCGAGGCATGGCTGAAGGAGAACGGGATCACCGAGCACCCGGACACGTTCGCCAGTCATCCGCCGCGCTCCCTGGTGCTCATCCCGAAGGCGCTCCAGCCGCACGCCGACCGGGTGGACGAAGACGTGTACACCTTCGTCGGCGCCTGCCAGGGAGACCGCGCCGAGGAAGGCGGCTGGCAGCGGCCCGCCGGCGCGGAGAAGGTCGTCCTGGTGTCGCTCGGCTCGGCGTTCACCAAGCAGCCCGCCTTCTACCGGGAGTGCGTGCGCGCCTTCGGGAACCTGCCCGGCTGGCACCTCGTCCTCCAGATCGGCCGGAAGGTGACCCCCGCCGAACTGGGGGAGCTGCCGGACAACGTGGAGGTGCACGACTGGGTGCCGCAGCTCGCGATCCTGCGCCAGGCCGATCTGTTCGTCACCCACGCGGGCGCCGGCGGCAGCCAGGAGGGGCTGGCCACCGCGACGCCCATGATCGCCGTACCGCAGGCCGTCGACCAGTTCGGCAACGCCGACATGCTCCAAGGGCTCGGCGTCGCCCGGAAGCTGGCGACCGAGGAGGCCACCGCCGACCTGCTCCGCGAGACCGCCCTCGCTCTGGTGGACGACCCGGAGGTCGCGCGCCGGCTCCGGCGGATCCAGGCGGAGATGGCCCAGGAGGGCGGCACCCGGCGGGCGGCCGACCTCATCGAGGCCGAACTGCCCGCGCGCCACGAGCGGCAGGAGCCGGTGGGCGACCGACCCAACGGTGGGTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces antibioticus", "NCBI_taxonomy_id": "1890", "NCBI_taxonomy_cvterm_id": "36823"}, "protein_sequence": {"accession": "ABA42119.2", "sequence": "MTTQTTPAHIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIPPVFADKVAATGARPVLYHSTLPGPDADPEAWGSTLLDNVEPFLNDAIQALPQLADAYADDIPDLVLHDITSYPARVLARRWGVPAVSLSPNLVAWKGYEEEVAEPMWREPRQTERGRAYYARFEAWLKENGITEHPDTFASHPPRSLVLIPKALQPHADRVDEDVYTFVGACQGDRAEEGGWQRPAGAEKVVLVSLGSAFTKQPAFYRECVRAFGNLPGWHLVLQIGRKVTPAELGELPDNVEVHDWVPQLAILRQADLFVTHAGAGGSQEGLATATPMIAVPQAVDQFGNADMLQGLGVARKLATEEATADLLRETALALVDDPEVARRLRRIQAEMAQEGGTRRAADLIEAELPARHERQEPVGDRPNGG"}}}}}}}, "2020": {"$update": {"model_sequences": {"$update": {"sequence": {"4234": {"dna_sequence": {"fmax": "2126", "fmin": "206", "accession": "M18896.2", "strand": "+", "sequence": "ATGAAAATAATTAACTTAGGCATTCTGGCTCACGTTGACGCAGGAAAGACAACATTAACGGAAAGTTTATTGTATACCAGTGGTGCAATTGCAGAACTAGGGAGCGTAGATGAAGGCACAACAAGGACAGATACAATGAATTTGGAGCGTCAAAGGGGAATCACTATCCAGACAGCAGTGACATCTTTTCAGTGGGAGGATGTAAAAGTCAACATTATAGATACGCCAGGCCATATGGATTTTTTGGCGGAAGTATACCGTTCTTTATCCGTATTAGACGGAGCAGTATTATTAGTTTCTGCAAAGGATGGCATACAGGCACAGACCCGTATACTGTTTCATGCACTACAGATAATGAAGATTCCGACAATTTTTTTCATCAATAAAATTGACCAAGAGGGGATTGATTTGCCAATGGTATATCGGGAAATGAAAGCAAAGCTTTCTTCGGAAATTATAGTGAAGCAAAAGGTTGGGCAGCATCCCCATATAAATGTAACGGACAATGACGATATGGAACAGTGGGATGCGGTAATTATGGGAAACGATGAACTATTAGAGAAATATATGTCAGGGAAACCGTTTAAAATGTCAGAACTGGAACAGGAAGAAAACAGGAGATTCCAAAACGGAACGTTATTTCCCGTTTATCACGGAAGCGCTAAAAACAATCTGGGGACTCGGCAGCTTATAGAAGTAATTGCCAGTAAATTTTATTCATCAACGCCTGAAGGTCAATCTGAACTATGCGGGCAGGTTTTTAAGATTGAATATTCAGAGAAAAGGCGGCGTTTTGTTTATGTGCGTATATATAGCGGAACATTGCATTTGAGGGATGTTATTAGAATATCTGAAAAAGAGAAAATAAAAATCACAGAGATGTATGTTCCGACAAACGGTGAATTATATTCATCCGATACAGCCTGCTCTGGTGATATTGTAATTTTACCAAATGATGTTTTGCAGCTAAACAGTATTTTGGGGAACGAAATACTGTTGCCGCAGAGAAAATTTATTGAAAATCCTCTCCCTATGATCCAAACAACGATTGCAGTAAAGAAATCTGAACAGCGGGAAATATTGCTTGGGGCACTTACAGAAATTTCAGATTGCGACCCTCTTTTAAAATATTATGTGGATACTACAACGCATGAGATTATACTTTCTTTTTTGGGGAATGTGCAGATGGAAGTCATTTGTGCCATCCTTGAGGAAAAATATCATGTGGAGGCAGAAATAAAAGAGCCTACTGTTATATATATGGAAAGACCGCTTAGAAAAGCAGAATATACCATCCACATAGAAGTCCCGCCAAATCCTTTCTGGGCTTCTGTCGGGTTGTCCATAGAGCCGCTCCCTATTGGAAGCGGAGTGCAGTATGAAAGCAGAGTTTCACTTGGATATTTAAATCAATCGTTCCAAAATGCGGTTATGGAGGGGGTTCTTTATGGCTGCGAGCAGGGGCTGTATGGATGGAAAGTGACAGACTGTAAAATCTGTTTTGAATATGGATTGTATTATAGTCCTGTAAGTACCCCCGCAGACTTTCGGCTGCTTTCCCCTATCGTATTGGAGCAGGCTTTAAAAAAAGCAGGGACAGAACTATTAGAGCCATATCTCCACTTTGAAATTTATGCACCGCAGGAATATCTCTCACGGGCGTATCATGATGCTCCAAGGTATTGTGCAGATATTGTAAGTACTCAGATAAAGAATGACGAGGTCATTCTGAAAGGAGAAATCCCTGCTAGATGTATTCAAGAATACAGGAACGATTTAACTTATTTCACAAATGGGCAGGGAGTCTGCTTGACAGAGTTAAAAGGATACCAGCCAGCTATTGGTAAATTTATTTGCCAACCCCGCCGCCCGAATAGCCGTATAGATAAGGTTCGGCATATGTTCCACAAGTTAGCTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Campylobacter jejuni", "NCBI_taxonomy_id": "197", "NCBI_taxonomy_cvterm_id": "36772"}, "protein_sequence": {"accession": "AAA23033.2", "sequence": "MKIINLGILAHVDAGKTTLTESLLYTSGAIAELGSVDEGTTRTDTMNLERQRGITIQTAVTSFQWEDVKVNIIDTPGHMDFLAEVYRSLSVLDGAVLLVSAKDGIQAQTRILFHALQIMKIPTIFFINKIDQEGIDLPMVYREMKAKLSSEIIVKQKVGQHPHINVTDNDDMEQWDAVIMGNDELLEKYMSGKPFKMSELEQEENRRFQNGTLFPVYHGSAKNNLGTRQLIEVIASKFYSSTPEGQSELCGQVFKIEYSEKRRRFVYVRIYSGTLHLRDVIRISEKEKIKITEMYVPTNGELYSSDTACSGDIVILPNDVLQLNSILGNEILLPQRKFIENPLPMIQTTIAVKKSEQREILLGALTEISDCDPLLKYYVDTTTHEIILSFLGNVQMEVICAILEEKYHVEAEIKEPTVIYMERPLRKAEYTIHIEVPPNPFWASVGLSIEPLPIGSGVQYESRVSLGYLNQSFQNAVMEGVLYGCEQGLYGWKVTDCKICFEYGLYYSPVSTPADFRLLSPIVLEQALKKAGTELLEPYLHFEIYAPQEYLSRAYHDAPRYCADIVSTQIKNDEVILKGEIPARCIQEYRNDLTYFTNGQGVCLTELKGYQPAIGKFICQPRRPNSRIDKVRHMFHKLA"}}}}}}}, "478": {"$update": {"model_sequences": {"$update": {"sequence": {"4266": {"dna_sequence": {"fmax": "1046", "fmin": "185", "accession": "X13543.1", "strand": "+", "sequence": "ATGCATACGCAGAAGGCAATAACGGAGGCGCTTCAAAAACTCGGAGTCCAATCCGGTGACCTGTTGATGGTGCATGCCTCACTTAAATCGATTGGTCCGGTCGAAGGAGGAGCGGAGACGGTCGTCGCCGCGTTACGCTCCGCGGTTGGGCCGACTGGCACTGTGATGGGATACGCATCGTGGGACCGATCACCCTACGAGGAGACTCTGAATGGCGCTCGGTTGGATGACAATGCCCGCCGTACCTGGCCGCCGTTCGATCCCGCAACGGCCGGGACTTACCGTGGGTTCGGCCTGCTGAATCAGTTTCTGGTTCAAGCCCCCGGCGCGCGGCGCAGCGCGCACCCCGATGCATCGATGGTCGCGGTTGGTCCGCTGGCTGAAACGCTGACGGAGCCTCACGAACTCGGTCACGCCTTGGGGGAAGGGTCGCCCAACGAGCGGTTCGTCCGCCTTGGCGGGAAGGCCCTGCTGTTGGGTGCGCCGCTAAACTCCGTTACCGCATTGCACTACGCCGAGGCGGTTGCCGATATACCCAATAAACGGTGGGTGACGTATGAGATGCCGATGCCTGGAAGAGACGGTGAAGTCGCCTGGAAAACGGCATCGGATTACGATTCAAACGGCATTCTCGATTGCTTTGCTATCGAAGGAAAGCAGGATGCGGTCGAAACTATAGCAAATGCTTACGTGAAGCTCGGTCGCCATCGAGAAGGTGTCGTGGGCTTTGCCCAGTGCTACCTGTTCGACGCGCAGGACATCGTGACGTTCGGCGTCACCTATCTTGAGAAGCATTTCGGAACCACTCCGATCGTGCCTGCGCACGAAGCCATCGAGCGCTCTTGCGAGCCTTCAGGTTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Plasmid pWP113a", "NCBI_taxonomy_id": "28425", "NCBI_taxonomy_cvterm_id": "39505"}, "protein_sequence": {"accession": "CAA31895.1", "sequence": "MHTQKAITEALQKLGVQSGDLLMVHASLKSIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDNARRTWPPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPNERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMPGRDGEVAWKTASDYDSNGILDCFAIEGKQDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPAHEAIERSCEPSG"}}}}}, "model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "560"}}}}}}, "823": {"$update": {"model_sequences": {"$update": {"sequence": {"$delete": ["446"], "$insert": {"4243": {"dna_sequence": {"fmax": "9582", "fmin": "8934", "accession": "X92945.2", "strand": "-", "sequence": "CTAAATCCAATCATCTACCCTATGAATTATATCTTGAAATTCATTCATAAATAGTGAAGCATGGTAACCATCACATACAGAATGATGAAGTTGCAGAGCAACTGGTATATAAATTTTATTATTCTCACTATAAAATTTACCTATCGTAATAATAGGCAATAAAAAGCTGCTATTGTTACCAATATTTAAATTAAATGAACTAAAATCAATCCAAGGAATCATTGAAATCGGTATGGTGTTTTCAGGTATCGGTTTTTTAGGAAACATTTCTTCTTTATCTTTATATTCAAGCAAGTCATTTTTATAATTATTATAAAAAGAAATGAAGTTTTTATCAGATTCAGTCCAAATGTTAGTAAATTTTTCAGTTTGCTTATTAAAAACTGTATACAAAGGATTTAACTTATCCCAATAACCTAATTTATTCTCACTATTAATTCCTGTTCTAAACACTTTATTTTTATTTACAACTTCCATAATTGCATAAATTAAAGAGGGATAAATTTCATATCCTTTCTTTTTTATCATATCTTTAAACAAAGTAATATCAATTTCTTTAGTAATGCTATAAGTAGTTTGCTGATTAAAATAGTGTTCAAAATATTCTTTTCTATCCCAATTTTCTAATTCAATAATATTAAAAGTCAT"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecalis", "NCBI_taxonomy_id": "1351", "NCBI_taxonomy_cvterm_id": "35918"}, "protein_sequence": {"accession": "CAA63498.2", "sequence": "MTFNIIELENWDRKEYFEHYFNQQTTYSITKEIDITLFKDMIKKKGYEIYPSLIYAIMEVVNKNKVFRTGINSENKLGYWDKLNPLYTVFNKQTEKFTNIWTESDKNFISFYNNYKNDLLEYKDKEEMFPKKPIPENTIPISMIPWIDFSSFNLNIGNNSSFLLPIITIGKFYSENNKIYIPVALQLHHSVCDGYHASLFMNEFQDIIHRVDDWI"}}}}}}}}}, "$insert": {"2873": {"model_id": "2873", "ARO_accession": "3004357", "model_param": {"blastp_bit_score": {"param_value": "300", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "A chloramphenicol acetyltransferase identified in Brevibacillus brevis and shown to confer resistance to chloramphenicol antibiotics. Described by Pawlowski et al. 2017.", "model_sequences": {"sequence": {"4232": {"dna_sequence": {"fmax": "660", "fmin": "0", "accession": "KY753886.1", "strand": "+", "sequence": "ATGAAATTTCAGCGAATCGATCTAGATAATTGGAGCAGAAGGTCTTATTTCGAGCATTATCTGAACCGAGTGAATTGCACCTTCAGTATGACTGCCAACATAGATATAACGGAATTGCTGCCCGCTCTACGGCAAAAGGAGATGAAGCTGTACCCGGCTTTTCTGTATATGGTGACAAACGCTGTCAATGCGCATCGTGAATTTCGGACTTCCTTCCATGCGGATGGCGAGTTGGGCTATTGGGAGAGCATGATACCCAGCTATACTTTTTTTCACCAGGATGATCAAACTTTTTCTACGATGTGGACGGAATTCGCTGACGAGTTCCCTGTGTTTTATCAAAATTACGTAGCGGATATGAAAAAGTATGGGGACAACAAAGGTCTTGTGGCAAAAGAGTTGGAACCGCCTTACACTTTCCCTGTCTCGTGTATTCCCTGGGTGAGCTTCAGTGGGTTTAATCTGAATATTTCGGGAGATGGGCGATATTTGCTGCCAATCATTACGAGCGGAAAGTATTTCGGGCAAGAAGGCAAAACGTTATTGCCTGTTTCTTTGCAGGTCCATCATGCGGTTTGTGATGGCTATCACGCGAGCCTGTTCATCCATGATCTGCAAAAATGGGCAACAAACTATAAGGAATGGTTAGGTGTCGAGTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Brevibacillus brevis Vm4", "NCBI_taxonomy_id": "1289602", "NCBI_taxonomy_cvterm_id": "41526"}, "protein_sequence": {"accession": "ATL63235.1", "sequence": "MKFQRIDLDNWSRRSYFEHYLNRVNCTFSMTANIDITELLPALRQKEMKLYPAFLYMVTNAVNAHREFRTSFHADGELGYWESMIPSYTFFHQDDQTFSTMWTEFADEFPVFYQNYVADMKKYGDNKGLVAKELEPPYTFPVSCIPWVSFSGFNLNISGDGRYLLPIITSGKYFGQEGKTLLPVSLQVHHAVCDGYHASLFIHDLQKWATNYKEWLGVE"}}}}, "ARO_category": {"36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "36524": {"category_aro_name": "chloramphenicol", "category_aro_cvterm_id": "36524", "category_aro_accession": "3000385", "category_aro_class_name": "Antibiotic", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation."}, "36526": {"category_aro_name": "phenicol antibiotic", "category_aro_cvterm_id": "36526", "category_aro_accession": "3000387", "category_aro_class_name": "Drug Class", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome."}, "36261": {"category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_cvterm_id": "36261", "category_aro_accession": "3000122", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini"}}, "ARO_name": "catV", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41525", "model_name": "catV", "model_type_id": "40292"}, "2882": {"model_id": "2882", "ARO_accession": "3004442", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "tet(W/N/W) is a mosaic tetracycline resistance gene and ribosomal protection protein.", "model_sequences": {"sequence": {"4270": {"dna_sequence": {"fmax": "21573", "fmin": "19653", "accession": "KU736867.1", "strand": "+", "sequence": "ATGAAAATAATCAATATTGGAATTCTTGCCCATGTAGACGCTGGAAAGACGACCTTGACGGAGAGCCTGCTATATGCCAGCGGAGCCATTTCAGAACCGGGGAGCGTCGAAAAAGGGACAACGAGGACGGACACCATGTTTTTGGAGCGGCAGCGTGGGATTACCATTCAAGCGGCAGTCACTTCCTTCCAGTGGCACAGATGTAAAGTTAACATTGTGGATACGCCCGGCCACATGGATTTTTTGGCGGAGGTGTACCGCTCTTTGGCTGTTTTAGATGGGGCCATCTTGGTGATCTCCGCTAAAGATGGCGTGCAGGCCCAGACCCGTATTCTGTTCCATGCCCTGCGGAAAATGAACATTCCCACCGTTATCTTTATCAACAAGATCGACCAGGCTGGCGTTGATTTGCAGAGCGTATATCAGTCTGTTCGGGATAAGCTCTCCGCCGATATTATCATCAAGCAGACGGTGTCGCTGTCCCCGGAAATAGTCCTGGAGGAAAATACCGACATAGAAGCATGGGATGCGGTCATCGAAAATAACGATGAATTATTGGAAAAGTATATCGCAGGAGAACCAATCAGCCGGGAAAAACTTGCGCGGGAGGAACAGCAGCGGGTTCAAGACGCCTCCCTGTTCCCAGTCTATCATGGCAGCGCCAAAAATGGCCTTGGCATTCAACCGTTGATGGATGCGGTGACAGGGCTGTTCCAACCGATTGGGGAACAGGGGGGCGCCGCCCTATGCGGCAGCGTTTTCAAGGTGGAGTATACAGATTGCGGCCAGAGGCTTGTCTATCTGCGGCTATACAGCGGAACGCTGCGTCTGCGGGATACGGTGGCCCTAGCCGGGAGAGAAAAGCTGAAAATCACAGAGATGCGTATTCCATCCAAAGGGGAGATTGTTCGGACAGATACCGCCCATAAGGGCGAAATTGTCATCCTTCCCAGCGACAGCTTGAGATTAAACGATATATTGGGGGACAAAACCCAACTTCCTCGTGAAATGTGGAGTGATGTTCCCTTCCCTATGCTGCGGACGACGATTACGCCAAAAACGGCAGAGCAAAGAGACCGGTTGCTGGACGCTCTTACGCAAATTGCGGATACTGACCCGCTTTTGCACTACGAGGTGGATTCCATCACCCATGAGATCATTCTTTCTTTTTTGGGCCGGGTGCAGTTGGAGGTTGTTTCCGCTTTGCTGTCGGAAAAATACAAGCTTGAAACAGTGGTAAAGGAACCCACCGTCATTTATATGGAGCGGCCGCTCAAAGCAGCCAGCCACACCATCCATATCGAGGTGCCGCCCAACCCGTTTTGGGCATCCATCGGACTGTCTGTTACACCACTCCCGCTTGGCTCCGGTGTACAATACGAGAGCCGGGTTTCGCTGGGATACTTGAACCAGAGTTTTCAAAACGCTGTCAGGGATGGTATCCGTTACGGGCTGGAGCAGGGCTTGTTCGGCTGGAACGTAACGGACTGTAAGATTTGCTTTGAATACGGGCTTTATTACAGTCCGGTCAGCACGCCGGCGGACTTCCGCTCATTGGCCCCGATTGTATTGGAACAGGCATTGAAGGAATCAGGGACGCAACTGCTGGAACCTTATCTCTCCTTCACCCTCTATGCGCCCCGGGAATATCTTTCCAGGGCTTATCATGATGCACCGAAATACTGTGCCACCATCGAAACGGTCCAGGTAAAAAAGGATGAAGTTGTCTTTACTGGCGAGATTCCCGCCCGTTGCATACAGGCATACCGTACTGATTTGGCCTTTTACACCAACGGGCGGAGTGTGTGCCTGACGGAACTGAAAGGGTATCAGGCCACTGTCGGCGAGCCAATCATCCAGCCCCGTCGTCCAAACAGCCGTTTGGATAAGGTGCGCCATATGTTCAGTAAGATTCCTTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "uncultured bacterium IN-02", "NCBI_taxonomy_id": "1805580", "NCBI_taxonomy_cvterm_id": "41635"}, "protein_sequence": {"accession": "AMP42147.1", "sequence": "MKIINIGILAHVDAGKTTLTESLLYASGAISEPGSVEKGTTRTDTMFLERQRGITIQAAVTSFQWHRCKVNIVDTPGHMDFLAEVYRSLAVLDGAILVISAKDGVQAQTRILFHALRKMNIPTVIFINKIDQAGVDLQSVYQSVRDKLSADIIIKQTVSLSPEIVLEENTDIEAWDAVIENNDELLEKYIAGEPISREKLAREEQQRVQDASLFPVYHGSAKNGLGIQPLMDAVTGLFQPIGEQGGAALCGSVFKVEYTDCGQRLVYLRLYSGTLRLRDTVALAGREKLKITEMRIPSKGEIVRTDTAHKGEIVILPSDSLRLNDILGDKTQLPREMWSDVPFPMLRTTITPKTAEQRDRLLDALTQIADTDPLLHYEVDSITHEIILSFLGRVQLEVVSALLSEKYKLETVVKEPTVIYMERPLKAASHTIHIEVPPNPFWASIGLSVTPLPLGSGVQYESRVSLGYLNQSFQNAVRDGIRYGLEQGLFGWNVTDCKICFEYGLYYSPVSTPADFRSLAPIVLEQALKESGTQLLEPYLSFTLYAPREYLSRAYHDAPKYCATIETVQVKKDEVVFTGEIPARCIQAYRTDLAFYTNGRSVCLTELKGYQATVGEPIIQPRRPNSRLDKVRHMFSKIP"}}}}, "ARO_category": {"36667": {"category_aro_name": "chlortetracycline", "category_aro_cvterm_id": "36667", "category_aro_accession": "3000528", "category_aro_class_name": "Antibiotic", "category_aro_description": "Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome."}, "36291": {"category_aro_name": "minocycline", "category_aro_cvterm_id": "36291", "category_aro_accession": "3000152", "category_aro_class_name": "Antibiotic", "category_aro_description": "Minocycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome."}, "35999": {"category_aro_name": "antibiotic target protection", "category_aro_cvterm_id": "35999", "category_aro_accession": "0001003", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "35921": {"category_aro_name": "tetracycline-resistant ribosomal protection protein", "category_aro_cvterm_id": "35921", "category_aro_accession": "0000002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein."}, "35968": {"category_aro_name": "tetracycline", "category_aro_cvterm_id": "35968", "category_aro_accession": "0000051", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome."}}, "ARO_name": "tet(W/N/W)", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41634", "model_name": "tet(W/N/W)", "model_type_id": "40292"}, "2880": {"model_id": "2880", "ARO_accession": "3004379", "model_param": {"blastp_bit_score": {"param_value": "900", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "A plasmid-mediate quinolone efflux pump variant described in Escherichia coli. QepA4 confers resistance to quinolone and fluoroquinolone antibiotics by expulsion from the cell. Described by Manageiro et al. 2017.", "model_sequences": {"sequence": {"4268": {"dna_sequence": {"fmax": "1536", "fmin": "0", "accession": "KX686116.1", "strand": "+", "sequence": "ATGTCCGCCACGCTCCACGACACCGCAGCGGATCGTCGGAAGGCCACCCGCCGCGAATGGATCGGCCTGGCCGTGGTCGCCCTGCCGTGCCTGGTCTACGCCATGGACCTCACGGTGCTGAACCTGGCGCTGCCGGTGCTCAGCCGTGAACTGCAGCCCTCCAGCGCCCAGCTTCTCTGGATCCTGGACATCTACGGCTTCTTCGTCGCCGGCTTCCTGATCACCATGGGCACGCTGGGCGACCGCATCGGCCGGCGCCGGCTGTTGTTGATCGGCGCGGCGTTATTCGCATTCGCCTCGGTGCTCGCGGCGCTGGCCGATACCGCCGCGCTGTTGATCGCGGCGCGCGCCTTGCTCGGCCTGGCCGGCGCCACCATCGCGCCGTCCACCATGGCGCTGATCCGCAACATGTTCCACGACCCGCGCCAGCGCCAGTTCGCCATCGGCGTGTGGATCGCCGCGTTTTCGCTGGGCAGCGCGATCGGTCCGCTGGTCGGCGGCGTGTTGCTGGAGTTCTTCCACTGGGGCGCCGTGTTCTGGCTCAACGTGCCGGTGATGCTGCTGACGCTGGCGCTCGGCCCTCGCTTCCTGCCCGAGTATCGTGATCCGGACGCGGGGCACCTGGACCTGGCCAGCGTGCTGCTGTCGCTGGCGGCGGTGCTGCTGACGATCTACGGGCTCAAGCAGTTGGCCGAGCATGGAGCGGGCCTCGCCTCGATGGCTGCGCTGCTGGCCGGGCTGGCGGTCGGGGCGCTGTTCCTGCGCCGCCAGGGCCACATCGCCTACCCGCTGCTGGACCTGCGGCTGTTCGCGCACGCGCCGTTCCGCGCGGCGCTGGCGGCGTATGCGCTGGCCGCGCTGGCCATGTTCGGCGTCTACATCTTCATGACGCAGTACCTGCAGCTCGTGCTGGGGCTGTCGCCGCTGCAGGCCGGGCTGGCCACGCTGCCCTGGTCCCTGTGCTTCGTCATCGGTTCGCTGTTGTCGCCGCAGCTCGCGGCGCGCTGGCCGGCGGCGCGCATCCTCGTCGTGGGCCTGTCGGCAGCGGCGTTCGGCTTCGCCGTGCTGGGGCTGGGGCAGGGCCTGTGGTGGCTGGTGCCGGCCACGATCGTCATGGGCCTGGGCCTGGCGCCGGTGTTCACCATCGGCAACGAGATCATCATCACCAGCGCGCCGTCCGAGCGCGCGGGCGCGGCCTCGGCCTTGTCGGAGACGGTGTCCGAATTCAGCGGCGCGCTGGGCATCGCGCTGTTCGGCAGCGTCGGCCTGGTGGTCTACCGGCAGGCGCTGACCAGCGCGGCGCTGCCCGGCCTGCCGGCCGATGCGCTGCAGGCGGCCGGTGCCTCGCTCGGGGGCGCCGTGCACCTGGCCGACACCCTGCCGGCGTGGCAGGGCGCGGCCTTGCTGGCGGCCGCACGCGCGGGCTTCACCGATGCGCTGCAGGCCACGGCCTGGGCCGGCGCGGTGCTGGTGCTGGTGGCCGCTGGGCTGGTGGCGCGCCTGCTGCGCAAGCGCCCAGCGCTCGCATCTGGTTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AQX36338.1", "sequence": "MSATLHDTAADRRKATRREWIGLAVVALPCLVYAMDLTVLNLALPVLSRELQPSSAQLLWILDIYGFFVAGFLITMGTLGDRIGRRRLLLIGAALFAFASVLAALADTAALLIAARALLGLAGATIAPSTMALIRNMFHDPRQRQFAIGVWIAAFSLGSAIGPLVGGVLLEFFHWGAVFWLNVPVMLLTLALGPRFLPEYRDPDAGHLDLASVLLSLAAVLLTIYGLKQLAEHGAGLASMAALLAGLAVGALFLRRQGHIAYPLLDLRLFAHAPFRAALAAYALAALAMFGVYIFMTQYLQLVLGLSPLQAGLATLPWSLCFVIGSLLSPQLAARWPAARILVVGLSAAAFGFAVLGLGQGLWWLVPATIVMGLGLAPVFTIGNEIIITSAPSERAGAASALSETVSEFSGALGIALFGSVGLVVYRQALTSAALPGLPADALQAAGASLGGAVHLADTLPAWQGAALLAAARAGFTDALQATAWAGAVLVLVAAGLVARLLRKRPALASG"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "QepA4", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41553", "model_name": "QepA4", "model_type_id": "40292"}, "2881": {"model_id": "2881", "ARO_accession": "3004441", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "Tet(59) is a chromosome-encoded tetracycline efflux pump described from a Chinese pig manure sample.", "model_sequences": {"sequence": {"4269": {"dna_sequence": {"fmax": "23515", "fmin": "22312", "accession": "KU736879.1", "strand": "+", "sequence": "ATGAATAAATTTGCGATCACCGCTTTAACGATCACCGCCCTAGATGCTATGGGGATCGGCTTGATCATGCCTGTATTGCCTACATTGTTACGTGAATACGTGTCGGCTGAAAATTTAGCAAATCATTACGGTATCCTGCTGGCACTGTATGCCATCATGCAGGTTTTTTTTGCTCCTCTACTTGGCAAATGGTCTGATAAATTCGGGCGCCGACCAATATTACTACTATCTCTTGCAGGCGCTGCTGTGGATTACACTTTGCTTGCATTATCTAGCTCACTTTGGATGCTATACGTTGGGCGATTAATTTCTGGAGTTACTGGCGCAACAGGTGCGGTCGCCGCTTCTGTTATTGCTGACAATACTGCTTCACAAGAGCGTACTAAGTGGTTTGGACGCTTAGGGGCGGCTTTTGGTATCGGGTTAATCGCTGGCCCTGCAATTGGCGGCTTTACAGGGCAATTCTCAGCTCACCTTCCTTTTATTATTGCTGCCATTTTAAATGCGCTCTCTTTTTTAGTTATTATGTTGATATTTAAAGATAATAAAATCAAAAATACTGAAAAAAACACCACAGAAACAGCAGAAAATTCGCGACCTTTCCTGCAAGTGATCAAGCCAGTCATACTATTGTTATTTATCTTTTTTATGACTCAAATGATAGGGCAAATTCCAGCAACGACATGGGTGTTATTTACGGAACATCGTTTTCAATGGGGCAGTATGGAGGTCGGCCTATCTTTAGCGGGGTTAGGCATCATGCATGCCTTGTTCCAAGCATTTGTAGCGGGCGCAATCGCCAAGAAATTCAATGAAAAAGTGACGATTATTGTGGGCTTTGTTGTTGATGGAGCAGCATTCATTATTTTGTCATTATTGACAAAGGGTTGGATGATTTACCCTACATTAATCTTACTCGCCGGCGGCAGTATTGCGCTACCAGCCTTACAGGGGTTAATGTCAGCTCAAGTCAATCAAACTAACCAAGGTAAGCTACAAGGCGTTCTAGTCAGCTTAACCAATACGACGGGGGTGATCGGCCCATTATTATTTAGCTTTATTTTTGGTCAAACACTGGCAAGTTGGGATGGCTGGATATGGATGATTGGTGCGATAATGTATGTTTTATTGATTGTATTTATTTTATCTTTTTATAGAAGCACCAAAAAGATAGTTAAAATAGCGAAGCTACCAGCGAGCTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "uncultured bacterium IN-14", "NCBI_taxonomy_id": "1805592", "NCBI_taxonomy_cvterm_id": "41633"}, "protein_sequence": {"accession": "AMP42492.1", "sequence": "MNKFAITALTITALDAMGIGLIMPVLPTLLREYVSAENLANHYGILLALYAIMQVFFAPLLGKWSDKFGRRPILLLSLAGAAVDYTLLALSSSLWMLYVGRLISGVTGATGAVAASVIADNTASQERTKWFGRLGAAFGIGLIAGPAIGGFTGQFSAHLPFIIAAILNALSFLVIMLIFKDNKIKNTEKNTTETAENSRPFLQVIKPVILLLFIFFMTQMIGQIPATTWVLFTEHRFQWGSMEVGLSLAGLGIMHALFQAFVAGAIAKKFNEKVTIIVGFVVDGAAFIILSLLTKGWMIYPTLILLAGGSIALPALQGLMSAQVNQTNQGKLQGVLVSLTNTTGVIGPLLFSFIFGQTLASWDGWIWMIGAIMYVLLIVFILSFYRSTKKIVKIAKLPAS"}}}}, "ARO_category": {"36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "36667": {"category_aro_name": "chlortetracycline", "category_aro_cvterm_id": "36667", "category_aro_accession": "3000528", "category_aro_class_name": "Antibiotic", "category_aro_description": "Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome."}, "37012": {"category_aro_name": "oxytetracycline", "category_aro_cvterm_id": "37012", "category_aro_accession": "3000668", "category_aro_class_name": "Antibiotic", "category_aro_description": "Oxytetracycline is a derivative of tetracycline with a 5-hydroxyl group. Its activity is similar to other tetracyclines."}, "36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "35968": {"category_aro_name": "tetracycline", "category_aro_cvterm_id": "35968", "category_aro_accession": "0000051", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome."}}, "ARO_name": "tet(59)", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41632", "model_name": "tet(59)", "model_type_id": "40292"}, "2877": {"model_id": "2877", "ARO_accession": "3004362", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "A chromosome-carried OXA-48-like beta-lactamase, OXA-535, identified in Shewanella spp. JAB-1. Likely the progenitor to the plasmid-carried OXA-436. Expression of OXA-535 in E. coli demonstrated carbapenem-hydrolyzing activity. Described by Jousset et al. 2017.", "model_sequences": {"sequence": {"4262": {"dna_sequence": {"fmax": "798", "fmin": "0", "accession": "KX828709.1", "strand": "+", "sequence": "ATGCGTGCGTTAGCCTTATCGGCTGTGTTGATGGTGACAACGATGATTGGCATGCCTGCGGTAGCGAAGGAGTGGCAAGAGAACAAGAGCTGGAATGCTCACTTTAGCGAACATAAAACCCAAGGCGTGGTTGTGCTCTGGAACGAGAATACACAGCAGGGTTTTACTAACGATCTTAAACGGGCAAACCAAGCATTTTTACCAGCATCGACCTTTAAGATCCCAAACAGTTTAATTGCCTTGGACTTAGGCGTGGTTAAGGATGAACATCAAGTCTTTAAATGGGATGGACAGACGCGTGATATCGCCGCGTGGAATCGTGACCATGATTTAATCACCGCGATGAAGTATTCGGTTGTGCCTGTTTATCAAGGATTTGCCCGCCAAATTGGCGAGGCACGTATGAGTAAAATGCTGCATGCCTTCGATTATGGCAATGAGGATATCTCGGGCAATTTAGACAGCTTTTGGCTCGATGGTGGTATTCGCATTTCGGCTACCCAGCAAATCGCTTTTTTACGCAAGCTCTACCACAACAAGCTGCACGTTTCTGAGCGTAGTCAGCGCATTGTCAAACAAGCCATGCTGACCGAGGCAAATGCTGACTATATCATCCGGGCGAAAACTGGCTATTCGGTCAGAATTGAACCGAAAATTGGTTGGTGGGTTGGCTGGGTCGAACTCGATGACAATGTGTGGTTCTTCGCGACTAATATGGATATGCCCACCGCTGAGGGCTTAGGGTTGCGTCAAAGCATTACGAAAGCAGTGCTGAAACAGGAAAAAATTATTCCTTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shewanella sp.", "NCBI_taxonomy_id": "50422", "NCBI_taxonomy_cvterm_id": "41536"}, "protein_sequence": {"accession": "AOQ26572.1", "sequence": "MRALALSAVLMVTTMIGMPAVAKEWQENKSWNAHFSEHKTQGVVVLWNENTQQGFTNDLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLITAMKYSVVPVYQGFARQIGEARMSKMLHAFDYGNEDISGNLDSFWLDGGIRISATQQIAFLRKLYHNKLHVSERSQRIVKQAMLTEANADYIIRAKTGYSVRIEPKIGWWVGWVELDDNVWFFATNMDMPTAEGLGLRQSITKAVLKQEKIIP"}}}}, "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36026": {"category_aro_name": "OXA beta-lactamase", "category_aro_cvterm_id": "36026", "category_aro_accession": "3000017", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime."}}, "ARO_name": "OXA-535", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41535", "model_name": "OXA-535", "model_type_id": "40292"}, "2876": {"model_id": "2876", "ARO_accession": "3003128", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "An OXA-48-like plasmid-encoded beta-lactamase shown to confer resistance to carbapenems through hydrolysis. Identified in multiple Enterobacteriaceae isolates from several patients in Denmark. Beta-lactamase activity against carbapenems and penicillins but little to no activity against cephalosporin antibiotics. Described by Samuelsen et al. 2017.", "model_sequences": {"sequence": {"4261": {"dna_sequence": {"fmax": "141723", "fmin": "140925", "accession": "KY863418.1", "strand": "+", "sequence": "ATGCGTGCGTTAGCCTTATCGGCTGTGTTGATGGTGACAACGATGATTGGCATGCCTGCGGTGGCAAAGGAGTGGCAAGAGAACAAGAGTTGGAATGCTCACTTTAGCGAACATAAAACCCAAGGCGTGGTTGTGCTCTGGAACGAGAATACACAGCAGGGTTTTACCAACGATCTTAAACGGGCAAACCAAGCATTTTTACCTGCATCGACCTTTAAGATCCCAAACAGTTTAATTGCCTTGGACTTAGGTGTGGTTAAGGATGAGCATCAAGTCTTTAAATGGGATGGACAGACGCGAGATATCGCCGCGTGGAATCGCGACCATGACTTAATCACCGCGATGAAGTATTCGGTTGTGCCTGTTTATCAAGAATTTGCCCGCCAAATTGGCGAGGCCCGTATGAGTAAAATGTTGCACGCCTTCGATTATGGTAATGAGGATATCTCGGGCAATTTGGACAGTTTTTGGCTCGATGGTGGTATTCGCATTTCGGCTACCCAGCAAATCGCTTTTTTACGCAAGCTGTACCACAACAAGTTGCACGTTTCTGAGCGTAGTCAGCGCATCGTTAAACAAGCCATGCTGACCGAGGCAAATGCCGACTATATCATCCGGGCGAAAACTGGCTATTCGGTCAGAATTGAACCGAAAATCGGTTGGTGGGTTGGCTGGATCGAACTGGATGACAATGTGTGGTTCTTCGCGACAAATATGGATATGCCCACCGCTGAGGGCTTAGGGTTGCGTCAAACCATTACGAAAGCAGTGCTGAAACAGGAAAAAATTATTCCTTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter asburiae", "NCBI_taxonomy_id": "61645", "NCBI_taxonomy_cvterm_id": "36926"}, "protein_sequence": {"accession": "ARX76025.1", "sequence": "MRALALSAVLMVTTMIGMPAVAKEWQENKSWNAHFSEHKTQGVVVLWNENTQQGFTNDLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNLDSFWLDGGIRISATQQIAFLRKLYHNKLHVSERSQRIVKQAMLTEANADYIIRAKTGYSVRIEPKIGWWVGWIELDDNVWFFATNMDMPTAEGLGLRQTITKAVLKQEKIIP"}}}}, "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36026": {"category_aro_name": "OXA beta-lactamase", "category_aro_cvterm_id": "36026", "category_aro_accession": "3000017", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime."}}, "ARO_name": "OXA-436", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "39705", "model_name": "OXA-436", "model_type_id": "40292"}, "2875": {"model_id": "2875", "ARO_accession": "3004361", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "sul4 is a dihydropteroate synthase gene and mobile sulfonamide resistance gene shown to confer resistance when expressed in E. coli.", "model_sequences": {"sequence": {"4260": {"dna_sequence": {"fmax": "964", "fmin": "100", "accession": "NG_056174.1", "strand": "+", "sequence": "ATGTCAACCACACTAACCAGCTTCAAATGGGGTGAACGCACCTACATCATGGGCATCCTCAACGTCACTCCAGACAGCTTTTCTGGAGATGGCGTTATGGTTGAAGAAGATGTCATCGCCAAAGCGGTAGCCCAGGCCAAACAATTTGTAGCCGACGGCGCAGACATCATCGACATTGGCGGCGAGAGTACCCGCCCTGGCAGCTCACCTATAAGCGCAGAGGAAGAACTGGCGCGGGTGCTGCCGGTGGTGCAGGCCGTACGCCAGGCTGTGGACGTCGTTATTTCCATCGACAGCTACCGCGCTTCCGTGGCCGAAGCGGCCCTGGCGGCAGGCGCCAGCTGGCTCAACGACGTCTGGGGGCTGCGCATGGACCCGGACATGGCCGGCCTGGCAGCACAAGCCGGCTGCCCCATCGTCCTTATGCACAACCGCAGCAAACCAAAGAACATAGCGCAAGAAAAAAAGCTGGGCGGGCGCTTCATCGGGGTAAAATACGACGACCTCATCACCGACGTTAAACGTGAATTACAAGAAAGCATCGACATCGCCTTAAAAGCCGGCGTAAAAGAGTCCCAAATTATCCTGGATCCCGGCATCGGCTTCGGTAAAACCGTCGAGCAAAGTTTGCAACTGCTCGACCAGATTAATCAGTTCAAAACAATGGGATTTCCCATCTTAATAGGTCCGTCGCGCAAATCATTTATTGGCTATACGCTCGATTTGCCGCCAGACCAGCGCATAGAAGGAACGGCGGCCACCGTCGCCATTGGCATTGACCGAGGAGCCGACGTTGTGCGCGTCCATGACGTCAAAGCAATCGTTCGGGTCGCCCGTATGACAGATGCAATCGTGAGACGTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "uncultured bacterium", "NCBI_taxonomy_id": "77133", "NCBI_taxonomy_cvterm_id": "36791"}, "protein_sequence": {"accession": "WP_102607457.1", "sequence": "MSTTLTSFKWGERTYIMGILNVTPDSFSGDGVMVEEDVIAKAVAQAKQFVADGADIIDIGGESTRPGSSPISAEEELARVLPVVQAVRQAVDVVISIDSYRASVAEAALAAGASWLNDVWGLRMDPDMAGLAAQAGCPIVLMHNRSKPKNIAQEKKLGGRFIGVKYDDLITDVKRELQESIDIALKAGVKESQIILDPGIGFGKTVEQSLQLLDQINQFKTMGFPILIGPSRKSFIGYTLDLPPDQRIEGTAATVAIGIDRGADVVRVHDVKAIVRVARMTDAIVRR"}}}}, "ARO_category": {"36421": {"category_aro_name": "sulfonamide antibiotic", "category_aro_cvterm_id": "36421", "category_aro_accession": "3000282", "category_aro_class_name": "Drug Class", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway."}, "41402": {"category_aro_name": "sulfonamide resistant sul", "category_aro_cvterm_id": "41402", "category_aro_accession": "3004238", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The sul genes encode forms of dihydropteroate synthase that confer resistance to sulfonamide."}, "35998": {"category_aro_name": "antibiotic target replacement", "category_aro_cvterm_id": "35998", "category_aro_accession": "0001002", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance."}}, "ARO_name": "sul4", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41534", "model_name": "sul4", "model_type_id": "40292"}, "2874": {"model_id": "2874", "ARO_accession": "3004359", "model_param": {"blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "A class A beta-lactamase described in Acidaminococcus fermentans. ACI-1 was the first description of a beta-lactamase enzyme in a gram-negative anaerobic cocci. Described by Galan et al 2000.", "model_sequences": {"sequence": {"4259": {"dna_sequence": {"fmax": "1094", "fmin": "239", "accession": "AJ007350.1", "strand": "+", "sequence": "ATGAAGAAATTTTGTTTTTTGTTTTTGATAATCTGTGGCTTGATGGTTTTCTGCCTTCAGGATTGTCAAGCGCGGCAGAAATTAAATCTTGCTGATCTGGAAAATAAATATAACGCCGTGATTGGTGTTTACGCCGTTGACATGGAGAATGGAAAAAAAATTTGCTACAAACCTGATACGCGTTTTTCCTACTGCTCGACACACAAAGTTTTTACGGCTGCAGAATTGCTAAGACAAAAAAATACCTCCGATTTGAATGAAATTCGTAAGTTTTCGGCGGAAGATATTTTGTCCTACGCGCCAATCACCAAAGACCATGTTGCTGATGGCATGACGCTGGCGGAAATTTGTTCGGCATCGCTCAGGTGGAGTGACAACACGGCGGCAAATTTAATTTTGCAGGAGATCGGCGGCGTGGAAAATTTCAAGGTGGCACTTAAAAATATTGGCGACAAAACTACCAAACCTGCGCGAAATGAACCTGAACTTAATCTTTTCAATCCAAAAGATAATCGTGATACTAGCACGCCGAGACAGATGGTAAAAAATTTGCAAGTCTATATATTCGGCGATATTTTGAGCGACGACAAGAAAAAACTGCTGATTGATTGGATGAGCGACAATTCCATAACCGACACGCTTATCAAGGCAGAAACTCCGCAAGGTTGGAAAGTTATCGACAAGAGCGGTTCAGGCGATTATGGGGCGCGGAATGATATTGCCGTGATTTATCCGCCCAATCGCAAACCCATTGTCATGGCGATAATGTCGCGCCGCACGGAAAAAAATGCAAAATCTGACGACGCTATGATTGCGGAGGCGGCAAAACGAATTTTTGATAATTTAGTATTTTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acidaminococcus fermentans", "NCBI_taxonomy_id": "905", "NCBI_taxonomy_cvterm_id": "41532"}, "protein_sequence": {"accession": "CAB51471.1", "sequence": "MKKFCFLFLIICGLMVFCLQDCQARQKLNLADLENKYNAVIGVYAVDMENGKKICYKPDTRFSYCSTHKVFTAAELLRQKNTSDLNEIRKFSAEDILSYAPITKDHVADGMTLAEICSASLRWSDNTAANLILQEIGGVENFKVALKNIGDKTTKPARNEPELNLFNPKDNRDTSTPRQMVKNLQVYIFGDILSDDKKKLLIDWMSDNSITDTLIKAETPQGWKVIDKSGSGDYGARNDIAVIYPPNRKPIVMAIMSRRTEKNAKSDDAMIAEAAKRIFDNLVF"}}}}, "ARO_category": {"36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "41530": {"category_aro_name": "ACI beta-lactamase", "category_aro_cvterm_id": "41530", "category_aro_accession": "3004358", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A family of class A beta-lactamase enzymes described in the gram-negative cocci Acidaminococcus fermentans."}}, "ARO_name": "ACI-1", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41531", "model_name": "ACI-1", "model_type_id": "40292"}, "2879": {"model_id": "2879", "ARO_accession": "3004378", "model_param": {"blastp_bit_score": {"param_value": "900", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "A plasmid-mediate quinolone efflux pump described in Enterobacter aerogenes and Escherichia coli. QepA3 confers resistance to fluoroquinolone antibiotics by expelling the antibiotic molecules from the cell. This is distinct from the usual chromosomal mutation mechanism of quinolone resistance. Described by Wang et al. 2017.", "model_sequences": {"sequence": {"4267": {"dna_sequence": {"fmax": "1536", "fmin": "0", "accession": "JQ064560.1", "strand": "+", "sequence": "ATGTCCGCCACGCTCCACGACACCGCAGCGGATCGTCGGAAGGCCACCCGCCGCGAATGGATCGGCCTGGCCGTGGTCGCCCTGCCGTGCCTGGTCTACGCCATGGACCTCACGGTGCTGAACCTGGCGCTGCCGGTGCTCAGCCGTGAACTGCAGCCCTCCAGCGCCCAGCTTCTCTGGATCCTGGACATCTACGGCTTCTTCGTCGCCGGCTTCCTGATCACCATGGGCACGCTGGGCGACCGCATCGGCCGGCGCCGGCTGTTGTTGATCGGCGCGGCGTTCTTCGCATTCGCCTCGGTGCTCGCGGCGCTGGCCGATACCGCCGCGCTGTTGATCGCGGCGCGCGCCTTGCTCGGCCTGGCCGGCGCCACCATCGCGCCGTCCACCATGGCGCTGGTCCGCAACATGTTCCACGACCCGCGCCAGCGCCAGTTCGCCATCGGCGTGTGGATCGCCGCGTTTTCGCTGGGCAGCGCGATCGGTCCGCTGGTCGGCGGCGTGTTGCTGGAGTTCTTCCACTGGGGCGCCGTGTTCTGGCTCAACGTGCCGGTGATGCTGCTGACGCTGGCGCTCGGCCCTCGCTTCCTGCCCGAGTATCGTGATCCGGACGCGGGGCACCTGGACCTGGCCAGCGTGCTGCTGTCGCTGGCGGCGGTGCTGCTGACGATCTACGGGCTCAAGCAGTTGGCCGAGCATGGAGAGGGCCTCGCCTCGATGGCTGCGCTGCTGGCCGGGCTGGCGGTCGGGGCGCTGTTCCTGCGCCGCCAGGGCCACATCGCCTACCCGCTGCTGGACCTGCGGCTGTTCGCGCACGCGCTGTTCCGCGCGGCGCTGGCGGCGTATGCGCTGGCCGCGCTGGCCATGTTCGGCGTCTACATCTTCATGACGCAGTACCTGCAGCTCGTGCTGGGGCTGTCGCCGCTGCAGGCCGGGCTGGCCACGCTGCCCTGCTCCCTGTGCTTCGTCATCGGTTCGCTGTTGTCGCCGCAGCTCGCGGCGCGCTGGCCGGCGGCGCGCATCCTCGTCGTGGGCCTGTCGGCAGCGGCGTTCGGCTTCGCCGTGCTGGGGCTGGGGCAGGGCCTGTGGTGGCTGGTGCCGGCCACGATCGTCAAGGGCCTGGGCCTGGCGCCGGTGTTCACCATCGGCAACGAGATCATCATCACCAGCGCGCCGTCCGAGCGCGCGGGCGCGGCCTCGGCCTTGTCGGAGACGGTGTCCGAATTCAGCGGCGCGCTGGGCATCGCGCTGTTCGGCAGCGTCGGCCTGGTGGTCTACCGGCAGGCGCTGACCAGCGCGGCGCTGCCCGGCCTGCCGGCCGATGCGCTGCAGACGGCCGGTGCCTCGCTCGGGGGCGCCGTGCACCTGGCCGACACCCTGCCGGCGTGGCAGGGCGCGGCCTTGCTGGCGGCCGCACGCGCGGGCTTCACCGATGCGCTGCAGGCCACGGCCTGGGCCGGCGCGGTGCTGGTGCTGGTGGCCGCTGGGCTGGTGGCGCGCCTGCTGCGCAAGCGCCCAGCGCTCGCATCTGGTTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter aerogenes", "NCBI_taxonomy_id": "548", "NCBI_taxonomy_cvterm_id": "36770"}, "protein_sequence": {"accession": "AEZ36150.1", "sequence": "MSATLHDTAADRRKATRREWIGLAVVALPCLVYAMDLTVLNLALPVLSRELQPSSAQLLWILDIYGFFVAGFLITMGTLGDRIGRRRLLLIGAAFFAFASVLAALADTAALLIAARALLGLAGATIAPSTMALVRNMFHDPRQRQFAIGVWIAAFSLGSAIGPLVGGVLLEFFHWGAVFWLNVPVMLLTLALGPRFLPEYRDPDAGHLDLASVLLSLAAVLLTIYGLKQLAEHGEGLASMAALLAGLAVGALFLRRQGHIAYPLLDLRLFAHALFRAALAAYALAALAMFGVYIFMTQYLQLVLGLSPLQAGLATLPCSLCFVIGSLLSPQLAARWPAARILVVGLSAAAFGFAVLGLGQGLWWLVPATIVKGLGLAPVFTIGNEIIITSAPSERAGAASALSETVSEFSGALGIALFGSVGLVVYRQALTSAALPGLPADALQTAGASLGGAVHLADTLPAWQGAALLAAARAGFTDALQATAWAGAVLVLVAAGLVARLLRKRPALASG"}}}}, "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "QepA3", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41552", "model_name": "QepA3", "model_type_id": "40292"}, "2889": {"model_id": "2889", "ARO_accession": "3004450", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "A class C beta-lactamase enzyme identified from Aeromonas enteropelogenes. TRU-1 confers resistance to penicillin and cephalosporin antibiotics.", "model_sequences": {"sequence": {"4275": {"dna_sequence": {"fmax": "1149", "fmin": "0", "accession": "NG_047550.1", "strand": "+", "sequence": "ATGAAACAACGAATCGCGCTATCACTGCTGGCATTGGGGCCCCTGTTGCTCGTCCCACGCGTTTATGCCGCGGCAGATGAGCCCATGGCGAACATAGTGGAAAAGGCTGTCCAGCCGCTGCTGGAGGAGTACCGGATCCCGGGCATGGCGGTCGCCGTGCTGAAGGAGGGCAAGCCTCACTACTTCAATTATGGCGTCGCCAATCGGGAGAGCGGCCGGCGCATCAGCGAGCGGACCCTGTTCGAGATTGGTTCGGTCAGCAAGACCTTTACTGCGACCTTGGGCACCTACGCGGTCGTCAAAGGGGGCTTTCGGCTGGATGACAAGGTGAGCCAGCACGCGCCTTGGTTGCAGAATTCGGCGTTTGATCGCGTCACCATGGCCCAGCTGGCGACCTACAGCGCAGGGGGCTTGCCGTTGCAGTTTCCCGATGCGGTCGACTCAAACGAGAGAATGCGCCAGTACTACCGGCAGTGGTCACCGCTTTATGCGGCAGGCACTCATCGCGAGTACTCCAACCCCAGCATAGGTCTGTTCGGCCATCTGGCGGCGAGCACCCTGGGCCAACCATTCAGACAACTGATGAGCCAGACTCTGCTGCCCAAGCTCGATTTGCAGCACACCTATCTCGAGGTGCCAGACGCAGCCATGGTTGACTACGCCTATGGCTATTCGAAGGAAGACAAACCCGTCAGGGTCAATCCCGGAGTGCTGGCGGACGAAGCCTATGGCATCAAGACCAGCGCGGCGGATCTCATCAAGTTTGTGGGCGCCAACATGACAGGCAGTGGCGACAAGGCGGTGCAGCAAGCGCTGGCCATGACCCGTACCGGTTTCTACTCGGTGGGAGAGATGACCCAGGGGCTGGGGTGGGAGAGCTACGCCTATCCCGTGACCGAACAGGCGCTGCTGGCGGGCAATTCACCGGCGGTGAGCTTCAAGGCCAATCCGGTCAAACCCTTTGTGGCTCCCAGAGTGATGGGGAACGAGCGACTCTACAACAAGACAGGCTCGACCAACGGCTTTGGTGCCTATGTGGTGTTTGTCCCGGCCAGAGGCGTGGGCATCGTCATGCTGGCCAATCGCAACTACCCCATCGAGGCCAGGGTCAAGGCTGCCTATGCCATCATGCGCCATCTGGCACCCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Aeromonas enteropelogenes", "NCBI_taxonomy_id": "29489", "NCBI_taxonomy_cvterm_id": "41646"}, "protein_sequence": {"accession": "WP_042027926.1", "sequence": "MKQRIALSLLALGPLLLVPRVYAAADEPMANIVEKAVQPLLEEYRIPGMAVAVLKEGKPHYFNYGVANRESGRRISERTLFEIGSVSKTFTATLGTYAVVKGGFRLDDKVSQHAPWLQNSAFDRVTMAQLATYSAGGLPLQFPDAVDSNERMRQYYRQWSPLYAAGTHREYSNPSIGLFGHLAASTLGQPFRQLMSQTLLPKLDLQHTYLEVPDAAMVDYAYGYSKEDKPVRVNPGVLADEAYGIKTSAADLIKFVGANMTGSGDKAVQQALAMTRTGFYSVGEMTQGLGWESYAYPVTEQALLAGNSPAVSFKANPVKPFVAPRVMGNERLYNKTGSTNGFGAYVVFVPARGVGIVMLANRNYPIEARVKAAYAIMRHLAP"}}}}, "ARO_category": {"36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}}, "ARO_name": "TRU-1", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41645", "model_name": "TRU-1", "model_type_id": "40292"}, "2885": {"model_id": "2885", "ARO_accession": "3004445", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "RSA-2 is a class A beta-lactamase enzyme identified from a functional metagenomics study of contaminated river sediments in India.", "model_sequences": {"sequence": {"4272": {"dna_sequence": {"fmax": "852", "fmin": "0", "accession": "MG739504.1", "strand": "+", "sequence": "ATGATTAAAAAGATTATTTCTGGAGCTTGCTTGGTTTTGCTGGCTGGGTGCGTGTTGGGTGTGAAGCCGGCGGGGAAAGAGACGGGGTTTATGATTGATTCTGGACGTTTTGCCGGGATGGATGGCTGCGCTATTGTTTTTGATGCGCGGATGGGAAAAATTGCGGGGGTTTATGGGGAGAAGCGGTGCAAGGAACGGGTTACGGCTTGTTCTACGTTCAAGGTGCCGCTGGCTTTGATGGCTTTTGATTCTGGGGTGCTGAGCGACGAGAGCACGGTGCTGAAGTGGGATGGAGTGCAGTGGCCGTTCGACTCCTGGAACCAGGACCAGACGGCGGCCTCGTGGCTGCGCAATTCGGTGGTGTGGTATTCGCAGCGGCTGACTCCAATGCTGGGCTTGGAAAAGATAAAGGCTTACCTAAAGGCTTTCGATTACGGGAATCAGGACTTTTCTTCCGGCCTGACCAGCGCTTGGCTTACCATCACCAAGAGCGATACGAATCCGGATAAGGGCAGTCTTAAAATCTCAGCCTACGAGGAACTGGAGTTCTTTAGACGGTTTTGGCGTGGCGCGCTCCCGGTGAGCGGGGCCGCGGTGGAGAAGACTAAAAAAATGATTTACCTGGAGACCTCTCCCGGCGGTTATGCGCTGCACGGCAAGACCGGCTCCGGCTATCTCGACGGATTGACCGGGGATTTCGGCTGGTTCGCCGGCCACGTAGAGGGCAAAGGCCGGGAGTATTTTGTTGTAACGGCCGTCACGCGGAATGGGAATGCCGCCGACGCACGCATCCCCGGCCTGGTGGCGAAGGAACTCGCCAAGAACATCCTTAAAGATAATTCGGTCTGGTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "uncultured bacterium", "NCBI_taxonomy_id": "77133", "NCBI_taxonomy_cvterm_id": "36791"}, "protein_sequence": {"accession": "AUW34359.1", "sequence": "MIKKIISGACLVLLAGCVLGVKPAGKETGFMIDSGRFAGMDGCAIVFDARMGKIAGVYGEKRCKERVTACSTFKVPLALMAFDSGVLSDESTVLKWDGVQWPFDSWNQDQTAASWLRNSVVWYSQRLTPMLGLEKIKAYLKAFDYGNQDFSSGLTSAWLTITKSDTNPDKGSLKISAYEELEFFRRFWRGALPVSGAAVEKTKKMIYLETSPGGYALHGKTGSGYLDGLTGDFGWFAGHVEGKGREYFVVTAVTRNGNAADARIPGLVAKELAKNILKDNSVW"}}}}, "ARO_category": {"35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "41636": {"category_aro_name": "RSA beta-lactamase", "category_aro_cvterm_id": "41636", "category_aro_accession": "3004443", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity"}}, "ARO_name": "RSA-2", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41638", "model_name": "RSA-2", "model_type_id": "40292"}, "2884": {"model_id": "2884", "ARO_accession": "3004444", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "RSA-1 is a class A beta-lactamase resistance enzyme identified from a functional metagenomic study of contaminated river sediments.", "model_sequences": {"sequence": {"4271": {"dna_sequence": {"fmax": "858", "fmin": "0", "accession": "MG739510.1", "strand": "+", "sequence": "ATGGGAATGCAACTAGCTAGGTCGACGATCCTCACTGTTTTGCTCTGTCTGCCGATTGCTGTAACGGCTACGACTAAGGAGGAGATCCAAAAGATTGAGCGTCAGCGCAACCTCACGGTTGGCATCGCTCTTGTAGACGACGGGGGAACACTCCTGTTCGGTCATCGCGAAACGCAGCGCTTCGCCATGTGCTCGACATTTAAGTTGCCGCTGGCGGCTGCAACGCTTAAGCAAATCGAGAGCGGAAAGTGGTCTGCCGCCGAGCGGCTGAGCTATAGCGCTGGCCAATTAGATGCCTACGCGCCAGCTGCCAAGAGATATCTACCTACAGGCTACATCACGGTAGCTGAGGCTAACCAAGCCTCGGTCCAGCTCAGCGATAATACTGCTGCCAACTTGCTGCTTGACAAACTCGGAGGGCCATCGCAGCTCACATCCATGTTTCGCTCCCTCGGCGATTCCGTGAGTCGCCTGGATAGAAGAGAACCCGATTTGAACACCAACGTTTCGGGTGACCCGCGCGACACGACTACGCCGGGCGCGATGGCACGCATTGTCGCAAAGCTGGTATATGGAAACTATCTAAGTACAGCAGGCCGAGAGCAATTGCAGCGGCTTCTCATTGGCAATAACACAGGCGACTCGAGGATTCGCGCTGGAATCGCATCTGGCTGGACGACTGGCGACAAAACGGGTTCCTGCCCCAATGGCGGACGAAATGACGCTGCGTTCCTGGTAAGCCCTGATGGCCGCAGATTTGCGCTGACAGTGTACCTGAACGCCCCATCGCTTGACGACAAGGCACGGAACGAGGTGGTCGCTACGGTAGCTCGCTTGGCGGTTGAGAGTATCCGCTAG"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "uncultured bacterium", "NCBI_taxonomy_id": "77133", "NCBI_taxonomy_cvterm_id": "36791"}, "protein_sequence": {"accession": "AUW34365.1", "sequence": "MGMQLARSTILTVLLCLPIAVTATTKEEIQKIERQRNLTVGIALVDDGGTLLFGHRETQRFAMCSTFKLPLAAATLKQIESGKWSAAERLSYSAGQLDAYAPAAKRYLPTGYITVAEANQASVQLSDNTAANLLLDKLGGPSQLTSMFRSLGDSVSRLDRREPDLNTNVSGDPRDTTTPGAMARIVAKLVYGNYLSTAGREQLQRLLIGNNTGDSRIRAGIASGWTTGDKTGSCPNGGRNDAAFLVSPDGRRFALTVYLNAPSLDDKARNEVVATVARLAVESIR"}}}}, "ARO_category": {"35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "41636": {"category_aro_name": "RSA beta-lactamase", "category_aro_cvterm_id": "41636", "category_aro_accession": "3004443", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity"}}, "ARO_name": "RSA-1", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41637", "model_name": "RSA-1", "model_type_id": "40292"}, "2886": {"model_id": "2886", "ARO_accession": "3004446", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}, "snp": {"param_type": "single resistance variant", "param_value": {"8325": "V562L", "8324": "L389F", "8321": "D350N", "8323": "S385T", "8322": "S357N"}, "clinical": {"8325": "V562L", "8324": "L389F", "8321": "D350N", "8323": "S385T", "8322": "S357N"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}}, "ARO_description": "PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics.", "model_sequences": {"sequence": {"4273": {"dna_sequence": {"fmax": "1199672", "fmin": "1197839", "accession": "NC_000907.1", "strand": "+", "sequence": "ATGGTGAAATTTAATTCCTCGCGTAAATCAGGTAAGTCAAAAAAAACAATTAGAAAATTGACCGCACCTGAAACTGTAAAGCAAAACAAGCCTCAAAAGGTGTTTGAAAAATGCTTTATGCGTGGACGTTATATGCTTTCTACGGTTCTTATTTTACTTGGCCTGTGTGCTTTAGTCGCACGAGCAGCTTATGTTCAATCTATTAATGCCGATACGTTATCGAATGAAGCGGATAAGCGTTCTTTGCGTAAAGATGAAGTATTATCGGTGCGTGGTTCTATTTTAGATCGTAATGGTCAGCTTTTATCTGTAAGCGTGCCGATGAGCGCGATTGTGGCAGATCCAAAAACGATGTTGAAGGAAAATTCGCTTGCGGATAAAGAACGAATTGCAGCTTTAGCCGAAGAATTAGGTATGACTGAAAATGATTTAGTGAAAAAAATTGAGAAAAATTCTAAATCTGGTTATTTGTATTTAGCACGTCAAGTTGAATTAAGTAAAGCTAACTATATTCGTAGATTAAAAATTAAGGGTATTATTTTAGAAACAGAGCATCGCCGTTTTTATCCTCGTGTAGAAGAAGCTGCACACGTGGTGGGTTATACGGATATTGATGGAAATGGTATTGAAGGCATTGAGAAAAGTTTTAATTCCCTGCTTGTTGGTAAAGACGGTTCACGTACTGTTCGTAAAGATAAACGTGGGAATATTGTTGCACATATCTCCGATGAGAAAAAATATGATGCACAAGATGTTACCTTAAGTATCGATGAAAAATTGCAATCTATGGTGTATCGTGAGATTAAAAAGGCGGTGTCTGAGAATAATGCTGAGTCTGGTACTGCGGTGTTAGTTGATGTTCGAACAGGGGAAGTGTTAGCTATGGCGACTGCGCCCTCTTATAATCCAAACAACCGTGTCGGCGTGAAATCAGAGTTAATGCGTAACCGTGCAATTACCGATACTTTTGAGCCAGGTTCTACGGTAAAACCTTTCGTTGTTTTAACCGCACTTCAACGAGGTGTAGTTAAACGAGATGAAATTATTGATACTACGTCCTTTAAATTAAGCGGTAAAGAAATTGTGGACGTTGCACCACGTGCTCAGCAAACTTTAGACGAGATTTTAATGAACTCTAGTAACCGTGGTGTAAGTCGTCTTGCATTACGTATGCCACCTAGTGCATTAATGGAAACTTATCAAAATGCAGGTTTAAGTAAACCGACAGATTTAGGCTTGATCGGAGAGCAAGTTGGGATTTTGAATGCAAATCGTAAACGCTGGGCAGATATTGAGCGTGCAACAGTCGCTTATGGTTATGGTATTACTGCGACACCTTTACAAATTGCTCGTGCCTATGCAACCCTTGGTAGTTTCGGTGTTTATCGTCCGCTTTCTATCACTAAAGTTGATCCGCCAGTTATTGGGAAACGGGTTTTCTCTGAAAAAATAACTAAAGATATTGTGGGAATTTTAGAGAAAGTAGCAATTAAAAATAAACGCGCAATGGTGGAAGGCTACCGTGTCGGCGTAAAAACAGGTACGGCACGTAAGATTGAAAATGGACATTATGTAAATAAGTATGTGGCATTTACTGCGGGTATTGCACCAATTAGTGATCCTCGTTATGCATTAGTGGTTTTGATCAATGATCCAAAAGCAGGAGAATATTATGGTGGTGCGGTTTCTGCCCCTGTATTCTCTAACATTATGGGCTATGCGTTACGTGCAAATGCTATTCCGCAAGATGCTGAAGCAGCTGAAAACACAACAACGAAAAGTGCAAAACGTATTGTTTATATTGGCGAACACAAGAATCAAAAAGTGAATTAA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Haemophilus influenzae Rd KW20", "NCBI_taxonomy_id": "71421", "NCBI_taxonomy_cvterm_id": "41640"}, "protein_sequence": {"accession": "NP_439290", "sequence": "MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN"}}}}, "ARO_category": {"37084": {"category_aro_name": "cefalotin", "category_aro_cvterm_id": "37084", "category_aro_accession": "3000704", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases."}, "36992": {"category_aro_name": "ceftibuten", "category_aro_cvterm_id": "36992", "category_aro_accession": "3000648", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftibuten is a semisynthetic cephalosporin active against Gram-negative bacilli. It is resistant against many plasmid-mediated beta-lactamases."}, "35981": {"category_aro_name": "amoxicillin", "category_aro_cvterm_id": "35981", "category_aro_accession": "0000064", "category_aro_class_name": "Antibiotic", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan."}, "35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "36993": {"category_aro_name": "cefditoren", "category_aro_cvterm_id": "36993", "category_aro_accession": "3000649", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefditoren is a semisynthetic cephalosporin active against staphylococci, streptococci, and and most enterobacteria. It is resistant to staphylococcal and most enterobacterial beta-lactamases, and is usually taken as the prodrug cefditoren pivoxil."}, "35995": {"category_aro_name": "piperacillin", "category_aro_cvterm_id": "35995", "category_aro_accession": "0000078", "category_aro_class_name": "Antibiotic", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria."}, "36991": {"category_aro_name": "cefpodoxime", "category_aro_cvterm_id": "36991", "category_aro_accession": "3000647", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefpodoxime is a semisynthetic cephalosporin that acts similarly to cefotaxime with broad-spectrum activity. It is stable to many plasmid-mediated beta-lactamses. Cefpodoxime is consumed as the prodrug cefpodoxime proxetil."}, "36990": {"category_aro_name": "cefixime", "category_aro_cvterm_id": "36990", "category_aro_accession": "3000646", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor."}, "36994": {"category_aro_name": "cefdinir", "category_aro_cvterm_id": "36994", "category_aro_accession": "3000650", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefdinir is similar to cefixime with a modified side-chain at its 7-amino position. It also shares similar activity with cefixime but is more active against staphylococci. It has also be shown to enhance phagocytosis."}, "35990": {"category_aro_name": "meropenem", "category_aro_cvterm_id": "35990", "category_aro_accession": "0000073", "category_aro_class_name": "Antibiotic", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem."}, "35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36309": {"category_aro_name": "imipenem", "category_aro_cvterm_id": "36309", "category_aro_accession": "3000170", "category_aro_class_name": "Antibiotic", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes."}, "35927": {"category_aro_name": "cefoxitin", "category_aro_cvterm_id": "35927", "category_aro_accession": "0000008", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases."}, "36689": {"category_aro_name": "aztreonam", "category_aro_cvterm_id": "36689", "category_aro_accession": "3000550", "category_aro_class_name": "Antibiotic", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death."}, "35980": {"category_aro_name": "cefuroxime", "category_aro_cvterm_id": "35980", "category_aro_accession": "0000063", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefuroxime is a second-generation cephalosporin antibiotic with increased stability with beta-lactamases than first-generation cephalosporins. Cefuroxime is active against Gram-positive organisms but less active against methicillin-resistant strains."}, "37085": {"category_aro_name": "isopenicillin N", "category_aro_cvterm_id": "37085", "category_aro_accession": "3000705", "category_aro_class_name": "Antibiotic", "category_aro_description": "Isopenicillin N is a natural penicillin derivative produced by Penicillium chrysogenum with activity similar to penicillin N."}, "35975": {"category_aro_name": "cefazolin", "category_aro_cvterm_id": "35975", "category_aro_accession": "0000058", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria."}, "37086": {"category_aro_name": "penicillin N", "category_aro_cvterm_id": "37086", "category_aro_accession": "3000706", "category_aro_class_name": "Antibiotic", "category_aro_description": "Penicillin N is a penicillin derivative produced by Cephalosporium acremonium."}, "35977": {"category_aro_name": "ceftazidime", "category_aro_cvterm_id": "35977", "category_aro_accession": "0000060", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections."}, "35976": {"category_aro_name": "cefepime", "category_aro_cvterm_id": "35976", "category_aro_accession": "0000059", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents."}, "35971": {"category_aro_name": "penicillin", "category_aro_cvterm_id": "35971", "category_aro_accession": "0000054", "category_aro_class_name": "Antibiotic", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "35973": {"category_aro_name": "oxacillin", "category_aro_cvterm_id": "35973", "category_aro_accession": "0000056", "category_aro_class_name": "Antibiotic", "category_aro_description": "Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis."}, "40928": {"category_aro_name": "cefmetazole", "category_aro_cvterm_id": "40928", "category_aro_accession": "3004001", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefmetazole is a semi-synthetic cephamycin antibiotic with broad spectrum antibiotic activity against both gram-positive and gram-negative bacteria, that disrupt cell wall synthesis through binding to PBPs causing cell lysis."}, "40944": {"category_aro_name": "moxalactam", "category_aro_cvterm_id": "40944", "category_aro_accession": "3004017", "category_aro_class_name": "Antibiotic", "category_aro_description": "Moxalactam (Latamoxef) is a broad spectrum cephalosporin (oxacephem) and beta-lactam antibiotic. Moxalactam binding to PBPs inhibits peptidoglycan cross-linkage in the cell wall, resulting in cell death. Moxalactam is proposed to be effective against meningitides as it passes the blood-brain barrier."}, "35930": {"category_aro_name": "cloxacillin", "category_aro_cvterm_id": "35930", "category_aro_accession": "0000011", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections."}, "36995": {"category_aro_name": "ceftaroline", "category_aro_cvterm_id": "36995", "category_aro_accession": "3000651", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftaroline is a novel cephalosporin active against methicillin resistant Staphylococcus aureus. Like other cephalosporins it binds penicillin-binding proteins to inhibit cell wall synthesis. It strongly binds with PBP2a, associated with methicillin resistance. It is taken orally as the prodrug ceftaroline fosamil."}, "35979": {"category_aro_name": "ceftriaxone", "category_aro_cvterm_id": "35979", "category_aro_accession": "0000062", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria."}, "35934": {"category_aro_name": "methicillin", "category_aro_cvterm_id": "35934", "category_aro_accession": "0000015", "category_aro_class_name": "Antibiotic", "category_aro_description": "Derived from penicillin to combat penicillin-resistance, methicillin is insensitive to beta-lactamases (also known as penicillinases) secreted by many penicillin-resistant bacteria. Methicillin is bactericidal, and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "40943": {"category_aro_name": "loracarbef", "category_aro_cvterm_id": "40943", "category_aro_accession": "3004016", "category_aro_class_name": "Antibiotic", "category_aro_description": "Loracarbef is a second-generation cephalosporin (carbacephem) and broad spectrum beta-lactam antibiotic. Loracarbef inhibits PBPs through binding, disrupting peptidoglycan cell wall cross-linkage and resulting in cell death."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36989": {"category_aro_name": "cefotaxime", "category_aro_cvterm_id": "36989", "category_aro_accession": "3000645", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups."}, "36988": {"category_aro_name": "cefaclor", "category_aro_cvterm_id": "36988", "category_aro_accession": "3000644", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefaclor is a semisynthetic cephalosporin derived from cephalexin. It has broad-spectrum antibiotic activity."}, "40661": {"category_aro_name": "Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics", "category_aro_cvterm_id": "40661", "category_aro_accession": "3003938", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics"}, "40929": {"category_aro_name": "cefonicid", "category_aro_cvterm_id": "40929", "category_aro_accession": "3004002", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefonicid is a second-generation cephalosporin-class beta-lactam antibiotic with broad spectrum activity. Particularly used against urinary tract infections and lower respiratory infections. Causes cell lysis by inactivation of PBPs through binding, inhibiting peptidoglycan synthesis."}, "36981": {"category_aro_name": "ampicillin", "category_aro_cvterm_id": "36981", "category_aro_accession": "3000637", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin."}, "36980": {"category_aro_name": "flucloxacillin", "category_aro_cvterm_id": "36980", "category_aro_accession": "3000636", "category_aro_class_name": "Antibiotic", "category_aro_description": "Flucloxacillin is similar to cloxacillin, with an extra additional fluorine atom."}, "36983": {"category_aro_name": "mezlocillin", "category_aro_cvterm_id": "36983", "category_aro_accession": "3000639", "category_aro_class_name": "Antibiotic", "category_aro_description": "Mezlocillin is a penicillin derivative taken parenterally."}, "36982": {"category_aro_name": "azlocillin", "category_aro_cvterm_id": "36982", "category_aro_accession": "3000638", "category_aro_class_name": "Antibiotic", "category_aro_description": "Azlocillin is a semisynthetic derivative of penicillin that is notably active against Ps. aeruginosa and other Gram-negative bacteria."}, "36985": {"category_aro_name": "cefalexin", "category_aro_cvterm_id": "36985", "category_aro_accession": "3000641", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefalexin is a cephalosporin antibiotic that causes filamentation. It is resistant to staphylococcal beta-lactamase, but degraded by enterobacterial beta-lactamases."}, "36984": {"category_aro_name": "doripenem", "category_aro_cvterm_id": "36984", "category_aro_accession": "3000640", "category_aro_class_name": "Antibiotic", "category_aro_description": "Doripenem is a carbapenem with a broad range of activity against Gram-positive and Gram-negative bacteria, and along with meropenem, it is the most active beta-lactam antibiotic against Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis."}, "36987": {"category_aro_name": "cefotiam", "category_aro_cvterm_id": "36987", "category_aro_accession": "3000643", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefotiam is a cephalosporin antibiotic with similar activity to cefuroxime but more active against enterobacteria. It is consumed orally as the prodrug cefotiam hexetil."}, "36986": {"category_aro_name": "cefadroxil", "category_aro_cvterm_id": "36986", "category_aro_accession": "3000642", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefadroxil, or p-hydroxycephalexin, is an cephalosporin antibiotic similar to cefalexin."}, "36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "37141": {"category_aro_name": "mecillinam", "category_aro_cvterm_id": "37141", "category_aro_accession": "3000761", "category_aro_class_name": "Antibiotic", "category_aro_description": "Mecillinam is a broad-spectrum beta-lactam antibiotic that was semi-synthetically derived to have a different drug centre, being a 6-alpha-amidinopenicillanate instead of a 6-alpha-acylaminopenicillanate. Contrasting most beta-lactam drugs, mecillinam is most active against Gram-negative bacteria. It binds specifically to penicillin binding protein 2 (PBP2)."}, "36979": {"category_aro_name": "dicloxacillin", "category_aro_cvterm_id": "36979", "category_aro_accession": "3000635", "category_aro_class_name": "Antibiotic", "category_aro_description": "Dicloxacillin is a penicillin derivative that has an extra chlorine atom in comparison to cloxacillin. While more active than cloxacillin, its high affinity for serum protein reduces its activity in human serum in vitro."}, "36978": {"category_aro_name": "propicillin", "category_aro_cvterm_id": "36978", "category_aro_accession": "3000634", "category_aro_class_name": "Antibiotic", "category_aro_description": "Propicillin is an orally taken penicillin derivative that has high absorption but poor activity."}, "35978": {"category_aro_name": "ceftobiprole", "category_aro_cvterm_id": "35978", "category_aro_accession": "0000061", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftobiprole (Zeftera/Zevtera) is a next generation (5th generation) cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci. Ceftobiprole inhibits transpeptidases essential to building cell walls, and is a poor substrate for most beta-lactamases."}, "36976": {"category_aro_name": "benzylpenicillin", "category_aro_cvterm_id": "36976", "category_aro_accession": "3000632", "category_aro_class_name": "Antibiotic", "category_aro_description": "Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid."}, "36977": {"category_aro_name": "phenoxymethylpenicillin", "category_aro_cvterm_id": "36977", "category_aro_accession": "3000633", "category_aro_class_name": "Antibiotic", "category_aro_description": "Phenoxymethylpenicillin, or penicillin V, is a penicillin derivative that is acid stable but less active than benzylpenicillin (penicillin G)."}, "35962": {"category_aro_name": "cephamycin", "category_aro_cvterm_id": "35962", "category_aro_accession": "0000044", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases."}, "35961": {"category_aro_name": "carbenicillin", "category_aro_cvterm_id": "35961", "category_aro_accession": "0000043", "category_aro_class_name": "Antibiotic", "category_aro_description": "Carbenicillin is a semi-synthetic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes. Carbenicillin antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "35923": {"category_aro_name": "monobactam", "category_aro_cvterm_id": "35923", "category_aro_accession": "0000004", "category_aro_class_name": "Drug Class", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "40933": {"category_aro_name": "ceftiofur", "category_aro_cvterm_id": "40933", "category_aro_accession": "3004006", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftiofur is a third-generation broad spectrum cephalosporin and beta-lactam antibiotic. It causes cell lysis by disrupting peptidoglycan cross-linkage and cell wall formation by binding to PBPs."}, "40932": {"category_aro_name": "cefprozil", "category_aro_cvterm_id": "40932", "category_aro_accession": "3004005", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefprozil is a cephalosporin and beta-lactam antibiotic with bactericidal activity. It selectively binds to PBPs and inhibits peptidoglycan synthesis, a major cell wall component, resulting in cell lysis."}, "40935": {"category_aro_name": "cephapirin", "category_aro_cvterm_id": "40935", "category_aro_accession": "3004008", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cephapirin is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Inactivation of penicillin-binding proteins through cephapirin binding disrupts peptidoglycan cross-linking, resulting in cell lysis."}, "40934": {"category_aro_name": "ceftizoxime", "category_aro_cvterm_id": "40934", "category_aro_accession": "3004007", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftizoxime is a third-generation cephalosporin and broad spectrum beta-lactam antibiotic. Ceftizoxime causes bacterial cell lysis through peptidoglycan cross-linking inhibition by binding to PBPs."}, "35987": {"category_aro_name": "ertapenem", "category_aro_cvterm_id": "35987", "category_aro_accession": "0000070", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis."}, "40936": {"category_aro_name": "cefradine", "category_aro_cvterm_id": "40936", "category_aro_accession": "3004009", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefradine is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Cefradine binding to penicillin-binding proteins disrupts cell wall peptidoglycan cross-linkage, resulting in cell lysis."}}, "ARO_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: \"strict\" and \"loose\". A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "ARO_id": "41639", "model_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "model_type_id": "40293"}, "2888": {"model_id": "2888", "ARO_accession": "3004448", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "A class A beta-lactamase with penicillinase activity described in Atlantibacter (Escherichia) hermannii", "model_sequences": {"sequence": {"4274": {"dna_sequence": {"fmax": "873", "fmin": "0", "accession": "AF311385.1", "strand": "+", "sequence": "ATGAAAAAAATCACCCCGCTCTTTGTCATCGCATTTCTGACTCTGATCGCGTTACTGGCCCCGGCGCAGGCCTCCGTCACGCCAGATATGACGGACTTTTTACGCCAGCAGGAGCAACGGCTTCACGCCAGAATTGGCATGGCGGTTGTCAACGCGCAAGGCGAAACGGTGTTCGGTTATCGGCAGGACGAGCGTTTCCCGCTGACCAGCACCTTTAAAACCCTGGCCTGCGCCGCGTTGCTTGAGCGGTTGCAGAAAAACGGCGGTTCGCTGGATGAACAGGTGACTATTCCGCCAGACGCCTTGCTGGACTATGCGCCAGTGACTAAAAACTACCTCGCCCCTGCCACCATCTCTTTACGCATGCTGTGCGCGGCGGCGGTGAGCTACAGCGACAACACGGCGGGCAACCGCATTCTGACTTACCTTGGCGGCCCTGATGCCGTCACGCAGTTTATGCGCGGGATCGGCGACCATGTGACCCGTCTGGATCGAACGGAGCCCACGCTGAATGAAGCCACGCCAGGCGATGCGCGCGATACCTCTTCGCCGCAGAAGATGGCGGCAGGGCTGCAAAAAATCCTCACCTCCCCTCCCCTGATATCGGCTAACCGGGCGACGCTGGCGCAGTGGATGCGTGACGATAAAGTGGGAGATGCGCTGCTACGCGCCGCGCTGCCGAAAGGCTGGGCAATTGCCGATAAAACCGGGGCGGGCGGCTACGGCTCGCGGGCGATTATCGCGGCGGTCTATCCGCCGGAACGCCCGCCGTTTTATGTCGCGATTTTTATTACGCAAACGGAAGCCTCGATGAAAATGGCAAATGAAACCATTGCTGAAATCGGCAAGCAGTTGTTTGCCGGGCAGCCCTGA"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Atlantibacter hermannii", "NCBI_taxonomy_id": "565", "NCBI_taxonomy_cvterm_id": "41643"}, "protein_sequence": {"accession": "AAL26797.1", "sequence": "MKKITPLFVIAFLTLIALLAPAQASVTPDMTDFLRQQEQRLHARIGMAVVNAQGETVFGYRQDERFPLTSTFKTLACAALLERLQKNGGSLDEQVTIPPDALLDYAPVTKNYLAPATISLRMLCAAAVSYSDNTAGNRILTYLGGPDAVTQFMRGIGDHVTRLDRTEPTLNEATPGDARDTSSPQKMAAGLQKILTSPPLISANRATLAQWMRDDKVGDALLRAALPKGWAIADKTGAGGYGSRAIIAAVYPPERPPFYVAIFITQTEASMKMANETIAEIGKQLFAGQP"}}}}, "ARO_category": {"36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "41641": {"category_aro_name": "HERA beta-lactamase", "category_aro_cvterm_id": "41641", "category_aro_accession": "3004447", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A class A beta-lactamase family shown to hydrolyze penicillin but without cephalosporinase activity."}}, "ARO_name": "HERA-1", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: \"perfect\", \"strict\" and \"loose\". A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "ARO_id": "41642", "model_name": "HERA-1", "model_type_id": "40292"}}}