Model_id Action ARO_name ARO_category Changes To Summary 3591 UPDATE FPH-1 penam; antibiotic inactivation; FPH beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 212 UPDATE Staphylococcus aureus parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_category "DELETED 40471 " 3595 UPDATE FTU-1 penam; antibiotic inactivation; FTU beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2292 UPDATE Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin clorobiocin; aminocoumarin antibiotic; novobiocin; coumermycin A1; antibiotic target alteration; aminocoumarin resistant parY; ARO_category "DELETED 40472 " 1347 UPDATE OXA-425 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; ARO_description "UPDATED ARO_description with OXA-425 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem-resistant " 3415 UPDATE OXA-151 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAATACGATAATTTCTCGCCGGTGGCGTGCCGGCCTGTGGCGGCGGCTGGTCGGCGCGGTCGTCTTGCCCGCAACGCTCGCCGCCACCCCTGCGGCCTATGCGGCCGACGTGCCGAAAGCCGCGCCGGGGCGCATCACCGAGCGCGCCGACTGGGGCAAGCTGTTCACCGCGGAGGGCGTGAAGGGCACGATCGTGGTGCTCGACGCACGCACGCAAACCTATCAGGCCTACGACGCCGCACGTGCCGAGAAGCGCATGTCGCCGGCGTCGACTTACAAGATATTCAACAGCCTGCTGGCGCTCGACTCCGGGGCGCTGGACAACGAACGCGCGATCATTCCCTGGGATGGCAAGCCGCGACGCATCAAGAACTGGAACGCGGCGATGGACCTGAGGACCGCGTTTCGCGTGTCATGCCTGCCCTGCTATCAGGTCGTCTCGCACAAGATCGGGCGCCGGTACGCGCAGGCGAAGCTGAACGAGGTCGGGTATGGCAACCGCACCATTGGCGGCGCGCCGGACGCCTATTGGGTCGACGACAGTCTGCAGATTTCGGCGCGTGAGCAGGTGGACTTCCTGCAGCGTCTCGCGCGTGGCACGTTGCCGTTCTCTGCGCGCTCGCAGGACATCGTGCGCCAGATGTCGATCGTCGAAGCCACGCCGGACTATGTGCTTCACGGCAAGACGGGCTGGTTCGTCGACAAGAAGCCCGATATCGGCTGGTGGGTAGGGTGGATCGAGCGCGACGGCAACATCGCCAGCGTCGCGATCAACATCGACATGCTGTCGGAGGCGGACGCCCCGAAACGGGCACGCATCGTGAAGTCGGTGCTGAAGGACCTGAAGCTGATCTGA UPDATED fmax with 1910080 UPDATED accession with UGSG01000001.1 UPDATED fmin with 1909222 UPDATED strand with - UPDATED NCBI_taxonomy_name with Pandoraea pnomenusa UPDATED NCBI_taxonomy_id with 93220 UPDATED NCBI_taxonomy_cvterm_id with 36932 UPDATED accession with SUA76968.1 UPDATED sequence with MNTIISRRWRAGLWRRLVGAVVLPATLAATPAAYAADVPKAAPGRITERADWGKLFTAEGVKGTIVVLDARTQTYQAYDAARAEKRMSPASTYKIFNSLLALDSGALDNERAIIPWDGKPRRIKNWNAAMDLRTAFRVSCLPCYQVVSHKIGRRYAQAKLNEVGYGNRTIGGAPDAYWVDDSLQISAREQVDFLQRLARGTLPFSARSQDIVRQMSIVEATPDYVLHGKTGWFVDKKPDIGWWVGWIERDGNIASVAINIDMLSEADAPKRARIVKSVLKDLKLI " 3417 UPDATE OXA-153 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAAAAGATAATTTCTCGCTGGCGGCGTGGTGTCTTCGGGCTGCGGGTTGCGCTCGCGGTCGTGTCTCCCATGGTGTTCGCCGTTCCGGCGCATGCGACGGAAGCGGCGGGCGGGGCCGCGGGGACTAAGGCCGCTGCGGTGCACATGAAGGAGCGTGCCGATTGGGGCAAGTTCTTCGATGCGGAAGGTGTTAAGGGAACGATCGTGGTGCTCGACGGACGCACGCAAACGTATCAGGCGTTCGACACGGCGCGCGCCGAGCGGCGGATGTCGCCTGCATCGACGTACAAGATCTTCAACAGCCTGCTGGCGCTCGAGTCGGGCGCCCTCGATAACGAACGCGAGATCATTCCCTGGGACGGCAAGCCGCGACGCGGGAAGTACTGGAACGCGGCGATGGATCTGCGCACGGCGTTTCGCGTGTCGTGTTTGCCGTGCTATCAGGTGGTCTCGCACAAGATTGCGCGTCAGTTTGCACAGAGCAAACTCAATGAGGCCGGGTATGGGAACCACACTATCGGTCGTGCCGCAGACGCCTACTGGGTCGACGACAGCTTGCAGATCTCGGCACGCGAGCAGGTCGATTTCCTGCAACGTCTCGCGCGAGGGACGTTACCGTTCTCTGCACGCTCGCAAGACATCGTGCGTCAGATTTCGATTGTCGAGGCCAATCCTGATTACGTGTTGCATGGCAAGACGGGCTGGTTCGTCGACAAGAAGCCGGACATCGGCTGGTGGGTGGGCTGGATTGAGCGCGACGGCAACATCACGAGCGTAGCGTTGAACATCGATCTGAAGGACGATGCCGATGCGCCCAAGCGCGCCCGTATCGTTCGTGCCGTGCTCAGTAGTTTGCAGTTGATCTGA UPDATED fmax with 24671 UPDATED accession with CEWL01000009.1 UPDATED fmin with 23801 UPDATED strand with - UPDATED NCBI_taxonomy_name with Pandoraea apista UPDATED NCBI_taxonomy_id with 93218 UPDATED NCBI_taxonomy_cvterm_id with 42785 UPDATED accession with CFB60580.1 UPDATED sequence with MKKIISRWRRGVFGLRVALAVVSPMVFAVPAHATEAAGGAAGTKAAAVHMKERADWGKFFDAEGVKGTIVVLDGRTQTYQAFDTARAERRMSPASTYKIFNSLLALESGALDNEREIIPWDGKPRRGKYWNAAMDLRTAFRVSCLPCYQVVSHKIARQFAQSKLNEAGYGNHTIGRAADAYWVDDSLQISAREQVDFLQRLARGTLPFSARSQDIVRQISIVEANPDYVLHGKTGWFVDKKPDIGWWVGWIERDGNITSVALNIDLKDDADAPKRARIVRAVLSSLQLI " 63 UPDATE AAC(6')-Ib antibiotic inactivation; kanamycin A; aminoglycoside antibiotic; AAC(6'); isepamicin; plazomicin; sisomicin; arbekacin; gentamicin B; netilmicin; amikacin; dibekacin; neomycin; tobramycin; ARO_category "DELETED 35933 " 3270 UPDATE dfrA18 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAATAAAGAAATTCAATTTTCAATGATTGTAGCGCGTGGTGTAAACGGTGAGATTGGTCAGGACGGCGACTTGCCTTGGCATGTCGAAGGAGTTCGGTTGAAAGAAGACCTCAAACGCTTCAAAGCGATCACTATGGGTAAGACACTCGTCATGGGCAGAAAGACCTTTGAGAGCATCCCCAATGGCCTGCCCGGACGCAACGTCATCGTGCTCACACGCGAGCCTTACGATAAAGCGGATATAACCGAACGTGGAGACGGCACCTTTGTAGCGTGGGGGAATAGCTGCCATCTGTTTGAAGTGGCCGAACACCTGGGCGTTACTGAGATCATCGTGGCGGGCGGTGCTGAAATCTATAATCTGCACAAAGACGTCATTACGAAGGTTTTTGAAACGAAGGTGTTGAGGGCGTATCCTGCAGCGGATACTCACGTAGACGTATTCTGGGAAAGTCCCGGATACGACACTGAAGGCCGACAATGGCGCGTAACGTCCAGAGGCCACATTATCGAAAACGGCAGTTTCACTATCGCGACGACGTATGAGCGATAG UPDATED fmax with 7967 UPDATED accession with AY034138.1 UPDATED fmin with 7412 UPDATED strand with - UPDATED NCBI_taxonomy_name with Vibrio cholerae MO10 UPDATED NCBI_taxonomy_id with 345072 UPDATED NCBI_taxonomy_cvterm_id with 39556 UPDATED accession with AAK64581.1 UPDATED sequence with MNKEIQFSMIVARGVNGEIGQDGDLPWHVEGVRLKEDLKRFKAITMGKTLVMGRKTFESIPNGLPGRNVIVLTREPYDKADITERGDGTFVAWGNSCHLFEVAEHLGVTEIIVAGGAEIYNLHKDVITKVFETKVLRAYPAADTHVDVFWESPGYDTEGRQWRVTSRGHIIENGSFTIATTYER " 2914 UPDATE Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin antibiotic target alteration; antibiotic target replacement; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifamycin antibiotic; ARO_description "UPDATED ARO_description with Bifidobacterium are antibiotic resistant probiotics are prescribed to upkeep the population beneficial bacteria in the gut microbiome. However, horizontal gene transfer among gut microbes could create harmful antibiotic-resistant pathogenic bacteria, such as Mycobacterium tuberculosis. Lokesh et al. analyzed Bifidobacterium antitubercular drug resistance and mutations in rpoB. They found that B. animalis, B. longum and B. adolescentis showed considerable resistance to pyrazinamide, isoniazid, and streptomycin, while B. adolescentis had mutations both in the rifampicin (RIF) pocket and in regions outside the pockets, and also showed considerable resistance to RIF. " 3558 UPDATE BAT-1 antibiotic inactivation; cephalosporin; BAT Beta-lactamase; ARO_category "UPDATED category_aro_name with cephalosporin UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_accession with 0000032 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. " 2785 UPDATE Klebsiella pneumoniae OmpK37 penam; carbapenem; penem; reduced permeability to antibiotic; cefotaxime; cephalosporin; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; cefoxitin; ARO_description "UPDATED ARO_description with Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35. " 3575 UPDATE CME-1 penam; antibiotic inactivation; CME beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3574 UPDATE CKO-1 CKO beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3576 UPDATE CMH-1 antibiotic inactivation; CMH beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_name with cephalosporin UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_accession with 0000032 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. " 3559 UPDATE BCL-1 penam; antibiotic inactivation; BCL Beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1549 UPDATE ErmB antibiotic target alteration; virginiamycin S2; vernamycin C; vernamycin B-gamma; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; pristinamycin IIA; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences "UPDATED partial with 1 UPDATED sequence with ATGAACAAAAATATAAAATATTCTCAAAACTTTTTAACGAGTGAAAAAGTACTCAACCAAATAATAAAACAATTGAATTTAAAAGAAACCGATACCGTTTACGAAATTGGAACAGGTAAAGGGCATTTAACGACGAAACTGGCTAAAATAAGTAAACAGGTAACGTCTATTGAATTAGACAGTCATCTATTCAACTTATCGTCAGAAAAATTAAAACTGAATACTCGTGTCACTTTAATTCACCAAGATATTCTACAGTTTCAATTCCCTAACAAACAGAGGTATAAAATTGTTGGGAGTATTCCTTACAATTTAAGCACACAAATTATTAAAAAAGTGGTTTTTGAAAGCCGTGCGTCTGACATCTATCTGATTGTTGAAGAAGGATTCTACAAGCGTACCTTGGATATTCACCGAACACTAGGGTTGCTCTTGCACACTCAAGTCTCGATTCAGCAATTGCTTAAGCTGCCAGCGGAATGCTTTCATCCTAAACCAAAAGTAAACAGTGTCTTAATAAAACTTACCCGCCATACCACAGATGTTCCAGATAAATATTGGAAGCTATATACGTACTTTGTTTCAAAATGGGTCAATCGAGAATATCGTCAACTGTTTACTAAAAATCAGTTTCATCAAGCAATGAAACACGCCAAAGTAAACAATTTAAGTACCATTACTTATGAGCAAGTATTGTCTATTTTTAATAGTTATCTATTATTTAACGGGAGGAAATTAATTCTATGA UPDATED fmax with 2878 UPDATED accession with AF242872.1 UPDATED fmin with 2131 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterococcus faecium UPDATED NCBI_taxonomy_id with 1352 UPDATED NCBI_taxonomy_cvterm_id with 36779 UPDATED accession with AAF86219.1 UPDATED sequence with MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFPNKQRYKIVGSIPYNLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRKLIL " 3580 UPDATE DES-1 penam; antibiotic inactivation; DES beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3582 UPDATE ERP-1 penam; antibiotic inactivation; ERP beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3583 UPDATE FAR-1 penam; antibiotic inactivation; FAR beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 991 UPDATE EreA antibiotic inactivation; macrolide esterase; macrolide antibiotic; roxithromycin; clarithromycin; erythromycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGACATGGAGAACGACCAGAACACTTTTACAGCCTCAAAAGCTGGACTTCAATGAGTTTGAGATTCTTACTTCCGTAATTGAGGGCGCCCGAATTGTCGGCATTGGCGAGGGCGCTCATTTTGTCGCGGAGTTTTCACTGGCTAGAGCTAGTCTTATCCGCTATTTGGTCGAAAGGCATGAGTTTAATGCGATTGGTTTGGAATGTGGGGCGATTCAGGCATCCCGGTTATCTGAATGGCTCAACTCAACAGCCGGTGCTCATGAACTTGAGCGATTTTCGGATACCCTGACCTTTTCTGTGTATGGCTCAGTGCTGATCTGGCTGAAATCATATCTCCGCGAATCAGGAAGAAAACTGCAGTTAGTCGGAATCGACTTACCCAACACCCTGAACCCAAGGGACGACCTAGCGCAATTGGCCGAAATTATCCAGCTCATCGATCACCTCATGAAACCGCACGTTGATATGTTGACTCACTTGTTGGCGTCCATTGATGGCCAGTCGGCGGTTATTTCATCGGCAAAATGGGGGGAGCTAGAAACGGCTCGGCAGGAGAAAGCTATCTCAGGGGTAACCAGATTGAAGCTCCGCTTGGCGTCGCTTGCCCCCGTCCTGAAAAAACACGTCAACAGCGATTTGTTCCGAAAAGCCTCTGATCGAATAGAGTCGATAGAGTATACGTTGGAAACCTTGCGTATAATGAAAACTTTCTTCGATGGTACCTCTCTTGAGGGAGATACTTCCGTACGTGACTCGTATATGGCGGGCGTAGTAGATGGAATGGTTCGAGCGAATCCGGATGTGAAGATAATTCTGCTGGCGCACAACAATCATCTACAAAAAACTCCAGTCTCCTTTTCAGGCGAGCTTACGGCTGTTCCCATGGGGCAGCACCTCGCAGAGAGGGTGAATTACCGTGCGATTGCATTCACCCATCTTGGACCCACCGTGCCGGAAATGCATTTCCCATCGCCAAAAAGTCCTCTTGGATTCTCTGTTGTGACCACGCCTGCCGATGCAATCCGTGAGGATAGTATGGAACAGTATGTCATCGACGCCTGTGGTACGGAGAATTCATGTCTGACATTGACAGATGCCCCCATGGAAGCAAAGCGAATGCGGTCTCAAAGCGCCTCTGTAGAAACGAAATTGAGCGAGGCATTTGATGCCATCGTCTGTGTTACAAGCGCCGGCAAGGACAGCCTGGTTGCCCTATAG UPDATED fmax with 3950 UPDATED accession with AY183453.1 UPDATED fmin with 2729 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAO38247.1 UPDATED sequence with MTWRTTRTLLQPQKLDFNEFEILTSVIEGARIVGIGEGAHFVAEFSLARASLIRYLVERHEFNAIGLECGAIQASRLSEWLNSTAGAHELERFSDTLTFSVYGSVLIWLKSYLRESGRKLQLVGIDLPNTLNPRDDLAQLAEIIQLIDHLMKPHVDMLTHLLASIDGQSAVISSAKWGELETARQEKAISGVTRLKLRLASLAPVLKKHVNSDLFRKASDRIESIEYTLETLRIMKTFFDGTSLEGDTSVRDSYMAGVVDGMVRANPDVKIILLAHNNHLQKTPVSFSGELTAVPMGQHLAERVNYRAIAFTHLGPTVPEMHFPSPKSPLGFSVVTTPADAIREDSMEQYVIDACGTENSCLTLTDAPMEAKRMRSQSASVETKLSEAFDAIVCVTSAGKDSLVAL " 3560 UPDATE BES-1 penam; antibiotic inactivation; BES Beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1135 UPDATE Staphylococcus aureus parE conferring resistance to aminocoumarin aminocoumarin resistant parE; clorobiocin; aminocoumarin antibiotic; novobiocin; coumermycin A1; antibiotic target alteration; model_sequences "UPDATED NCBI_taxonomy_name with Staphylococcus aureus subsp. aureus RN4220 " 3402 UPDATE Tet(X4) antibiotic inactivation; tigecycline; glycylcycline; tetracycline antibiotic; tetracycline inactivation enzyme; tetracycline; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAGCAATAAAGAAAAACAAATGAATTTACTTAGTGATAAGAACGTTGCAATAATTGGTGGTGGACCCGTTGGACTGACTATGGCAAAATTATTACAGCAAAACGGCATAGACGTTTCAGTTTACGAAAGAGACAACGACCGAGAGGCAAGAATTTTTGGTGGAACCCTTGACCTACACAAAGGTTCAGGTCAGGAAGCAATGAAAAAAGCGGGATTGTTACAAACTTATTATGACTTAGCCTTACCAATGGGTGTAAATATTGCTGATGAAAAAGGCAATATTTTATCCACAAAAAATGTAAAGCCCGAAAATCGATTTGACAATCCTGAAATAAACAGAAATGACTTAAGGGCTATCTTGTTGAATAGTTTAGAAAACGACACGGTTATTTGGGATAGAAAACTTGTTATGCTTGAACCTGGTAAGAAGAAGTGGACACTAACTTTTGAGAATAAACCGAGTGAAACAGCAGATCTGGTTATTATTGCCAATGGTGGAATGTCTAAAGTAAGAAAATTTGTTACCGACACGGAAGTTGAAGAAACAGGTACTTTCAATATACAAGCCGATATTCATCATCCAGAGGTGAACTGTCCTGGATTTTTTCAGCTATGCAATGGAAACCGGCTAATGGCTGCTCATCAAGGTAATTTATTATTTGCGAATCCTAATAATAATGGTGCATTGCATTTTGGAATAAGTTTTAAAACACCTGATGAATGGAAAAACCAAACGCAGGTAGATTTTCAAAACAGAAATAGTGTCGTTGATTTTCTTCTGAAAGAATTTTCCGATTGGGACGAACGCTACAAAGAACTGATTCGTGTGACATCATCTTTTGTAGGGTTAGCGACACGAATATTTCCCTTAGGTAAGTCTTGGAAAAGTAAGCGTCCATTACCCATAACGATGATTGGAGATGCTGCTCATTTGATGCCTCCTTTTGCAGGACAAGGCGTAAACAGCGGGTTGATGGATGCCTTGATATTGTCGGATAATCTGACCAATGGGAAATTTAACAGCATTGAAGAGGCTATTGAAAATTATGAACAGCAAATGTTTATCTATGGCAAAGAAGCACAAGAAGAATCAACTCAAAACGAAATTGAAATGTTTAAACCCGACTTTACGTTTCAGCAATTGTTAAATGTATAA UPDATED fmax with 1482 UPDATED accession with MK134376.1 UPDATED fmin with 324 UPDATED strand with - UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with QBQ69719.1 UPDATED sequence with MSNKEKQMNLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDLHKGSGQEAMKKAGLLQTYYDLALPMGVNIADEKGNILSTKNVKPENRFDNPEINRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVIIANGGMSKVRKFVTDTEVEETGTFNIQADIHHPEVNCPGFFQLCNGNRLMAAHQGNLLFANPNNNGALHFGISFKTPDEWKNQTQVDFQNRNSVVDFLLKEFSDWDERYKELIRVTSSFVGLATRIFPLGKSWKSKRPLPITMIGDAAHLMPPFAGQGVNSGLMDALILSDNLTNGKFNSIEEAIENYEQQMFIYGKEAQEESTQNEIEMFKPDFTFQQLLNV " 660 UPDATE Streptococcus pneumoniae parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_category "DELETED 40471 " 3562 UPDATE BIL-1 antibiotic inactivation; cephalosporin; BIL Beta-lactamase; ARO_category "UPDATED category_aro_name with cephalosporin UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_accession with 0000032 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. " 3563 UPDATE BKC-1 carbapenem; antibiotic inactivation; BKC Beta-lactamase; ARO_category "UPDATED category_aro_name with carbapenem UPDATED category_aro_cvterm_id with 35939 UPDATED category_aro_accession with 0000020 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. " 900 UPDATE tet(C) fosfomycin; benzalkonium chloride; tetracycline antibiotic; rhodamine; antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; macrolide antibiotic; cephalosporin; antibacterial free fatty acids; bicyclomycin; nitroimidazole antibiotic; lincosamide antibiotic; peptide antibiotic; acridine dye; diaminopyrimidine antibiotic; oxazolidinone antibiotic; penam; isoniazid; efflux pump complex or subunit conferring antibiotic resistance; glycylcycline; nucleoside antibiotic; fluoroquinolone antibiotic; phenicol antibiotic; tetracycline; rifamycin antibiotic; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAATCTAACAATGCGCTCATCGTCATCCTCGGCACCGTCACCCTGGATGCTGTAGGCATAGGCTTGGTTATGCCGGTACTGCCGGGCCTCTTGCGGGATATCGTCCATTCCGACAGCATCGCCAGTCACTATGGCGTGCTGCTAGCGCTATATGCGTTGATGCAATTTCTATGCGCACCCGTTCTCGGAGCACTGTCCGACCGCTTTGGCCGCCGCCCAGTCCTGCTCGCTTCGCTACTTGGAGCCACTATCGACTACGCGATCATGGCGACCACACCCGTCCTGTGGATCCTCTACGCCGGACGCATCGTGGCCGGCATCACCGGCGCCACAGGTGCGGTTGCTGGCGCCTATATCGCCGACATCACCGATGGGGAAGATCGGGCTCGCCACTTCGGGCTCATGAGCGCTTGTTTCGGCGTGGGTATGGTGGCAGGCCCCGTGGCCGGGGGACTGTTGGGCGCCATCTCCTTGCATGCACCATTCCTTGCGGCGGCGGTGCTCAACGGCCTCAACCTACTACTGGGCTGCTTCCTAATGCAGGAGTCGCATAAGGGAGAGCGTCGACCGATGCCCTTGAGAGCCTTCAACCCAGTCAGCTCCTTCCGGTGGGCGCGGGGCATGACTATCGTCGCCGCACTTATGACTGTCTTCTTTATCATGCAACTCGTAGGACAGGTGCCGGCAGCGCTCTGGGTCATTTTCGGCGAGGACCGCTTTCGCTGGAGCGCGACGATGATCGGCCTGTCGCTTGCGGTATTCGGAATCTTGCACGCCCTCGCTCAAGCCTTCGTCACTGGTCCCGCCACCAAACGTTTCGGCGAGAAGCAGGCCATTATCGCCGGCATGGCGGCCGACGCGCTGGGCTACGTCTTGCTGGCGTTCGCGACGCGAGGCTGGATGGCCTTCCCCATTATGATTCTTCTCGCTTCCGGCGGCATCGGGATGCCCGCGTTGCAGGCCATGCTGTCCAGGCAGGTAGATGACGACCATCAGGGACAGCTTCAAGGATCGCTCGCGGCTCTTACCAGCCTAACTTCGATCATTGGACCGCTGATCGTCACGGCGATTTATGCCGCCTCGGCGAGCACATGGAACGGGTTGGCATGGATTGTAGGCGCCGCCCTATACCTTGTCTGCCTCCCCGCGTTGCGTCGCGGTGCATGGAGCCGGGCCACCTCGACCTGA UPDATED fmax with 5175 UPDATED accession with AY043299.1 UPDATED fmin with 3984 UPDATED strand with - UPDATED NCBI_taxonomy_name with Aeromonas salmonicida UPDATED NCBI_taxonomy_id with 645 UPDATED NCBI_taxonomy_cvterm_id with 36795 UPDATED accession with AAK97755.1 UPDATED sequence with MKSNNALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALRRGAWSRATST " 3567 UPDATE CBP-1 penam; CBP beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2215 UPDATE Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolone antibiotic target alteration; fluoroquinolone resistant parC; fluoroquinolone antibiotic; ARO_category "DELETED 37010 " 2041 UPDATE OXA-424 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; ARO_description "UPDATED ARO_description with OXA-424 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii found in China. It is carbapenem resistant. " 3584 UPDATE FIM-1 carbapenem; antibiotic inactivation; cephalosporin; FIM beta-lactamase; ARO_category "UPDATED category_aro_name with carbapenem UPDATED category_aro_cvterm_id with 35939 UPDATED category_aro_accession with 0000020 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_name with cephalosporin UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_accession with 0000032 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. " 2230 UPDATE PEDO-3 carbapenem; antibiotic inactivation; subclass B1 PEDO beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGTTATCTTCTTTCCTTTTTACTTTGTTTATCTGCCTTTGCCTCTTTCGCGCAAAATCCAAAAATAAAAATCAAACATTTAACTGGCGATCTTTATGTTTACACCACATACAATACCTACAAAGGCGCTTTAACAGATGCAAATGCGGTTTACCTGGTTACCAATAAAGGTGTTGTAGTAATCGATGCCCCTTGGGATGCTACGCAGTTCCAGCCCTTTTTAGACTCTATTCAGACCAAACATCACCAAAAAGTAGTGCTGGCCATTGCCACACATTCGCATGGCGACCGCGCAGGCGGTTTAGCGTTCTTTAAAAGTAAGGGCATAAAAACCTATACCAATAAATTAACCGACGAAATTCTGAAAACTAATAAAGAGCCACGCGCAGCCTACACCTTTACCAACGACACTACTTTTACAGTGGGACAATATAAAATAAACACCTACTATGCCGGCAAGGGGCATACAAAGGATAATCTGGTAGTTTGGTTTCCAAAAGACAAAGTTTTATTCGGTGGCTGCCTGATTAAAAGCATCGAAGCCAATGATTTGGGCTATATTGGAGAATCCGATTTAGCCGCATGGCCAAAAAGCATCGAAAAGTTAAAACAGAAATATCCTGATACCAAAATTGTTATTACCGGACACGCTGCCTGGGGAAACAGGGAATCTCTAGACCATACCCTAAAGCTATTGAGGGAGAAAAAGTAG UPDATED fmax with 2974 UPDATED accession with KP109679 UPDATED fmin with 2260 UPDATED strand with - UPDATED NCBI_taxonomy_name with Pedobacter sp. Stok-3 UPDATED NCBI_taxonomy_id with 1620223 UPDATED NCBI_taxonomy_cvterm_id with 40285 UPDATED accession with AJP77076 UPDATED sequence with MRYLLSFLLCLSAFASFAQNPKIKIKHLTGDLYVYTTYNTYKGALTDANAVYLVTNKGVVVIDAPWDATQFQPFLDSIQTKHHQKVVLAIATHSHGDRAGGLAFFKSKGIKTYTNKLTDEILKTNKEPRAAYTFTNDTTFTVGQYKINTYYAGKGHTKDNLVVWFPKDKVLFGGCLIKSIEANDLGYIGESDLAAWPKSIEKLKQKYPDTKIVITGHAAWGNRESLDHTLKLLREKK " 3568 UPDATE CGA-1 penam; antibiotic inactivation; CGA beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2235 UPDATE SPG-1 carbapenem; SPG beta-lacatamase; antibiotic inactivation; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGCCCCCTGATACTGCTCGCATCCGCGCTCGCCATGACAGCCCCATCCGGCGCCCTCGCCCAATCGGCCGAGCAGCGCGCGAAATGGAACGGGCCGCGCGAGCCATTCCGCATCACCGGCAATCTCTATTATGTCGGCACCAGCGGGCTTTCGGCCTATCTGATCGCCGGGCCGCGCGGCCATGTGCTGATCGACGGCGCTCTGCCGGAAAGCGCGCCGCTGATCGCCGCGAACATCCGCAAACTGGGCTTCAAACTGTCCGATGTGAAATATCTGCTCAGCAACCATTCGCATGTCGATCACGCCGGTGGACTGGCCGAACTCAAGCGGCTGACCGGCGCGCAAATGGTCGCAAACGTTGCGGACAAGCCCGATCTCGAAGCAGGTACCACCATCGGCCGCACCGATATCGCGGACTTTCCGGCAGTGAAGGTCGATCGTGTGATCGGCGACGGCGACCGGCTGACGCTCGGCCCGATCGCGCTCGTCGCCATCCTGACACCCGGCCATACAAAAGGCGCGACGAGCTGGACGACCCGCATTGGCAGCAAGAATGTGATCTTCACATCGAGTATCAGTGTCGCCGGCCAAAATCTTATCAATAATATAAATTATCCGAACGCCGCCGCCGATTTCCGTGCCAGCTTTGCGAAACTCCGCGCGTTGAAGGCAGATATCTTCCTGAGCTTCCACGCCGAGGCTTTCGCGCTCGATGAAAAACGCGCCAGGGCGCAGGCGGGTGCCACCGACGCCTTTGTCGATCCGAACGAATTGTCACGCCAGGTCGATCTGGCGGAGAAGGCTTTCGATGCGACGCTGGCGAAGCAGCAAGCGGCGAATGCGGATCGGCGCTGA UPDATED fmax with 2112 UPDATED accession with KP109680 UPDATED fmin with 1254 UPDATED strand with - UPDATED NCBI_taxonomy_name with Sphingomonas sp. ALS-13 UPDATED NCBI_taxonomy_id with 1620224 UPDATED NCBI_taxonomy_cvterm_id with 40286 UPDATED accession with AJP77080 UPDATED sequence with MRPLILLASALAMTAPSGALAQSAEQRAKWNGPREPFRITGNLYYVGTSGLSAYLIAGPRGHVLIDGALPESAPLIAANIRKLGFKLSDVKYLLSNHSHVDHAGGLAELKRLTGAQMVANVADKPDLEAGTTIGRTDIADFPAVKVDRVIGDGDRLTLGPIALVAILTPGHTKGATSWTTRIGSKNVIFTSSISVAGQNLINNINYPNAAADFRASFAKLRALKADIFLSFHAEAFALDEKRARAQAGATDAFVDPNELSRQVDLAEKAFDATLAKQQAANADRR " 2310 UPDATE Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin antibiotic target alteration; elfamycin antibiotic; kirromycin; elfamycin resistant EF-Tu; ARO_category "DELETED 40497 " 2397 UPDATE pgpB peptide antibiotic; polymyxin B1; lipid A phosphatase; polymyxin B2; polymyxin B3; polymyxin B4; antibiotic target alteration; ARO_description "UPDATED ARO_description with A gene that produces the protein lipid A 4'-phosphatase " 3561 UPDATE BIC-1 carbapenem; BIC Beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_name with carbapenem UPDATED category_aro_cvterm_id with 35939 UPDATED category_aro_accession with 0000020 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. " 1450 UPDATE Escherichia coli parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_category "DELETED 40471 " 2753 UPDATE HMB-1 carbapenem; antibiotic inactivation; HMB beta-lactamase; ARO_description "UPDATED ARO_description with Shotgun cloning of beta-lactam resistant P. aeruginosa NRZ-03096 yielded a clone producing a novel subclass B1 enzyme with only 74.3% identity to the next nearest relative, KHM-1. The novel MBL was named HMB-1 (for Hamburg MBL). HMB-1 gene was chromosomally located as part of a Tn 3 family transposon that was named Tn 6345, where expression of bla HMB-1 in E. coli TOP10 led to increased resistance to beta-lactams. " 2083 UPDATE Mycoplasma hominis parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_category "DELETED 40471 " 2104 UPDATE Ureaplasma urealyticum parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_category "DELETED 40471 " 3414 DELETE OXA-135 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; N/A N/A 2898 DELETE Shigella flexneri chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; N/A N/A 737 DELETE MIR-8 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; N/A N/A 3613 ADD HERA-4 penam; HERA beta-lactamase; antibiotic inactivation; N/A N/A 3614 ADD HERA-5 penam; HERA beta-lactamase; antibiotic inactivation; N/A N/A 3615 ADD HERA-6 penam; HERA beta-lactamase; antibiotic inactivation; N/A N/A 3616 ADD HERA-8 penam; HERA beta-lactamase; antibiotic inactivation; N/A N/A 3617 ADD IMI-8 carbapenem; antibiotic inactivation; IMI beta-lactamase; N/A N/A 3618 ADD IMP-49 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A 3620 ADD LAP-1 antibiotic inactivation; LAP beta-lactamase; tetracycline antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; rifamycin antibiotic; N/A N/A 3623 ADD LEN-25 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3622 ADD LEN-17 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3625 ADD LEN-36 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3624 ADD LEN-35 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3627 ADD SHV-4 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3626 ADD LEN-37 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3621 ADD LAP-2 antibiotic inactivation; LAP beta-lactamase; tetracycline antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; rifamycin antibiotic; N/A N/A 3619 ADD IMP-52 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A