Model_id Action ARO_name ARO_category Changes To Summary 3557 UPDATE AZECL-25 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_description; ARO_category; model_name; ARO_name "UPDATED ARO_description with MIR-23, originally described as AZECL-25, is a class C beta-lactamase that is found in Enterobacter cloacae. DELETED 42855 UPDATED category_aro_name with monobactam UPDATED category_aro_cvterm_id with 35923 UPDATED category_aro_accession with 0000004 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_name with MIR beta-lactamase UPDATED category_aro_cvterm_id with 36197 UPDATED category_aro_accession with 3000058 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams UPDATED model_name with MIR-23 UPDATED ARO_name with MIR-23 " 868 UPDATE DHA-1 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA UPDATED fmax with 2126 UPDATED accession with Y16410.1 UPDATED fmin with 986 UPDATED strand with + UPDATED NCBI_taxonomy_name with Salmonella enterica subsp. enterica serovar Enteritidis UPDATED NCBI_taxonomy_id with 149539 UPDATED NCBI_taxonomy_cvterm_id with 35750 UPDATED accession with CAA76196.1 UPDATED sequence with MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE " 2913 UPDATE OXA-286 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATCATGTCGAAAAAATTAACATGTCTGGCCCTGTTTACAGCCATCTTTTTTGCGATTCCCATGGCCGCTTGTCAAAGTTTTAGTCAACAAAAGCAACAGCTTTCGACACAGAAAAATGAACAGCAACAGATTTCAAGCTTATTTCAGAGTGCCCAAACCAGTGGTGTTTTGGTGATTTATGATGGCAAGAAAATTCAAAGCTATGGCAATGATCTTGATCGTGCAGAACAGCGCTATATTCCTGCCTCAACCTTTAAAATGCTAAATGCCTTGATTGGTATACAACATCATAAGACCACACCAGATGAAGTGTTTAAATGGGATGGCAAAAAGCGGGCATTCAGCAGTTGGGAAAAAGATTTAACCTTAGCTGAAGCGATGCAGGCATCGGCGGTACCTGTGTATCAGGAACTAGCAAGACGTATTGGCTTGGAGTTAATGACCCGTGAAGTGAAGCGTGTGGGTTATGGCAATAAAAATATTGGGACACAAGTTGATAATTTCTGGTTAGTTGGCCCATTAAAAATCACCCCCGTAGAAGAAGTTCGCTTTGCCTATGCGTTGGCAAAACAGAAATTGCCATTTGACCAGCCAACACAGCAACAAGTCAAAGCGATGTTATTGGTGGATCAGATTCAGGGAACTAAAATCTATGCAAAAAGTGGTTGGGGCATGGATGTTAGCCCGCAAGTGGGATGGTGGACAGGCTGGATTGAACAGCCAAATGGTAAGATCACAGCCTTCTCACTGAATATGCAAATGAGCCAGCCTGAGCATGCAGATGCACGTAAAGCGATTGTGTATCAAGCCTTGCAACAGTTGGGATTGTTAGCCCATTAA UPDATED fmax with 190328 UPDATED accession with APOI01000030.1 UPDATED fmin with 189485 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter sp. NIPH 809 UPDATED NCBI_taxonomy_id with 1217713 UPDATED NCBI_taxonomy_cvterm_id with 42970 UPDATED accession with ENU21708.1 UPDATED sequence with MIMSKKLTCLALFTAIFFAIPMAACQSFSQQKQQLSTQKNEQQQISSLFQSAQTSGVLVIYDGKKIQSYGNDLDRAEQRYIPASTFKMLNALIGIQHHKTTPDEVFKWDGKKRAFSSWEKDLTLAEAMQASAVPVYQELARRIGLELMTREVKRVGYGNKNIGTQVDNFWLVGPLKITPVEEVRFAYALAKQKLPFDQPTQQQVKAMLLVDQIQGTKIYAKSGWGMDVSPQVGWWTGWIEQPNGKITAFSLNMQMSQPEHADARKAIVYQALQQLGLLAH " 1223 UPDATE vph peptide antibiotic; viomycin phosphotransferase; antibiotic inactivation; viomycin; ARO_category "DELETED 36629 " 2133 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to viomycin peptide antibiotic; antibiotic target alteration; 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; ARO_category "DELETED 36629 " 3565 UPDATE BRO-1 penam; antibiotic inactivation; BRO Beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCAACGCCGGCATTTTTTACAAAAAACCTTATTGGCACTACCTATTATTTTTTCTGGCAATTTATTAACTGGATGTAAAACGAATTTATCTGATGATTATTTGCCCGATGATAAGATAACAAACAATCCAAATTTATTACAAAATAAATTAAAAGAGATATTGCCAATTTGGGAAAATAAATTTAATGCCAAAATTGGTATGACGATTATTGCTGACAATGGTGAACTATCCAGTCATCGTGGTAATGAATATTTTCCTGTTAATAGTACCATTAAAGCCTTTATTGCAAGTCATATATTATTACTTGTAGATAAAGAAAAATTGGATTTAAACGAAAAAATCATCATTAAAGAAAGCGATTTGATAGAATATTCTCCTGTCTGTAAAAAATACTTTGATGAGAATAAACCAATTTCTATTAGTGAATTGTGCGAAGCTACCATAACACTGAGTGATAATGGTTCTGCTAATATCTTGTTGGATAAAATTGGGGGTTTGACTGCATTCAATCAATTTTTGAAAGAGATTGGGGCGGATATGGTGCTGGCAAATAATGAGCCTTTATTAAATCGCTCACATTATGGTGAAACCAGTGATACCGCAAAACCAATTCCTTACACAAAAAGCCTAAAAGCACTGATTGTAGGCAATATCCTATCCAATCAAAGCAAAGAACAGTTGATAACTTGGCTTATCAATGATAAAGTTGCTGATAATTTATTGAGAAAATATTTACCAAAAAATTGGCGAATTGGCGACAAAACAGGCACAGGTAGTGAATCAAAAAATATCATTGCTGTGATTTGGAATGAAAATAATAAACCTTATTTTATCAGCCTATTTATCACCCAGCCCCATGATGGTAAATCCCTTGATTTTAAAAATCAAAAAGATGAAATAATGGCACAAATTGGTAAAGAAATTTATCCATTTTTATAA UPDATED fmax with 2917 UPDATED accession with U49269.2 UPDATED fmin with 1975 UPDATED strand with + UPDATED NCBI_taxonomy_name with Moraxella catarrhalis UPDATED NCBI_taxonomy_id with 480 UPDATED NCBI_taxonomy_cvterm_id with 41250 UPDATED accession with AAA92126.1 UPDATED sequence with MQRRHFLQKTLLALPIIFSGNLLTGCKTNLSDDYLPDDKITNNPNLLQNKLKEILPIWENKFNAKIGMTIIADNGELSSHRGNEYFPVNSTIKAFIASHILLLVDKEKLDLNEKIIIKESDLIEYSPVCKKYFDENKPISISELCEATITLSDNGSANILLDKIGGLTAFNQFLKEIGADMVLANNEPLLNRSHYGETSDTAKPIPYTKSLKALIVGNILSNQSKEQLITWLINDKVADNLLRKYLPKNWRIGDKTGTGSESKNIIAVIWNENNKPYFISLFITQPHDGKSLDFKNQKDEIMAQIGKEIYPFL " 1112 UPDATE OXA-58 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAATTATTAAAAATATTGAGTTTAGTTTGCTTAAGCATAAGTATTGGGGCTTGTGCTGAGCATAGTATGAGTCGAGCAAAAACAAGTACAATTCCACAAGTGAATAACTCAATCATCGATCAGAATGTTCAAGCGCTTTTTAATGAAATCTCAGCTGATGCTGTGTTTGTCACATATGATGGTCAAAATATTAAAAAATATGGCACGCATTTAGACCGAGCAAAAACAGCTTATATTCCTGCATCTACATTTAAAATTGCCAATGCACTAATTGGTTTAGAAAATCATAAAGCAACATCTACAGAAATATTTAAGTGGGATGGAAAGCCACGTTTTTTTAAAGCATGGGACAAAGATTTTACTTTGGGCGAAGCCATGCAAGCATCTACAGTGCCTGTATATCAAGAATTGGCACGTCGTATTGGTCCAAGCTTAATGCAAAGTGAATTGCAACGTATTGGTTATGGCAATATGCAAATAGGCACGGAAGTTGATCAATTTTGGTTGAAAGGGCCTTTGACAATTACACCTATACAAGAAGTAAAGTTTGTGTATGATTTAGCCCAAGGGCAATTGCCTTTTAAACCTGAAGTTCAGCAACAAGTGAAAGAGATGTTGTATGTAGAGCGCAGAGGGGAGAATCGTCTATATGCTAAAAGTGGCTGGGGAATGGCTGTAGACCCGCAAGTGGGTTGGTATGTGGGTTTTGTTGAAAAGGCAGATGGGCAAGTGGTGGCATTTGCTTTAAATATGCAAATGAAAGCTGGTGATGATATTGCTCTACGTAAACAATTGTCTTTAGATGTGCTAGATAAGTTGGGTGTTTTTCATTATTTATAA UPDATED fmax with 14226 UPDATED accession with CP000864.1 UPDATED fmin with 13383 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii ACICU UPDATED NCBI_taxonomy_id with 405416 UPDATED NCBI_taxonomy_cvterm_id with 35523 UPDATED accession with ACC58995.1 UPDATED sequence with MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL " 1066 UPDATE TEM-118 penam; antibiotic inactivation; penem; cephalosporin; monobactam; TEM beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with TTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCATTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACATGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACA UPDATED fmax with 785 UPDATED accession with AY130285 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella oxytoca UPDATED NCBI_taxonomy_id with 571 UPDATED NCBI_taxonomy_cvterm_id with 36788 UPDATED accession with AAN05029.1 UPDATED sequence with FFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNR " 2142 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin peptide antibiotic; antibiotic target alteration; 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; ARO_category "DELETED 36629 " 1655 UPDATE TEM-117 penam; antibiotic inactivation; penem; cephalosporin; monobactam; TEM beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with TTTTTTGCGGCATTTTGCTTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAAC UPDATED fmax with 764 UPDATED accession with AY130282 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAN05026.1 UPDATED sequence with FFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQAT " 2098 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin peptide antibiotic; antibiotic target alteration; 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; ARO_category "DELETED 36629 " 659 UPDATE AAC(6')-29b antibiotic inactivation; kanamycin A; aminoglycoside antibiotic; AAC(6'); isepamicin; sisomicin; arbekacin; gentamicin B; netilmicin; amikacin; dibekacin; neomycin; tobramycin; model_sequences "UPDATED partial with 0 UPDATED sequence with TTGAGCGTTTCGATCTTACCTGTGAAAGAACAAGACGCTGCCGACTGGCTAGCGCTGCGGAATCTTCTTTGGCTCGCGGATGATCACGCCTCGGAGATTGAGCAGTACTTCTCTGGTGGATTTGAGGAGCCTGCAGAAGTGCTCATCGCCCGTGATGCTACCGGCGCGGCTGTTGGGCATGTCGAACTCTCGATAAGACATGACTTGGAAGAACTCCAAGGAATCAAGACCGGCTACATCGAAGGCCTTTATGTGGCCCCAAGCCATCGATCAACAGACCTTGTGAGGCGTTTCTTGCGTGAGTCCGAGAAGTGGGCCCTAGAACAAGGGTGCAGCGCATTTGCCTCAGACAGAAGTGATCGGGTCATCACGCACCGCAAGTTCGCAGGCAGCGCCGTCTAA UPDATED fmax with 502 UPDATED accession with NG_048576.1 UPDATED fmin with 100 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with WP_064190969.1 UPDATED sequence with MSVSILPVKEQDAADWLALRNLLWLADDHASEIEQYFSGGFEEPAEVLIARDATGAAVGHVELSIRHDLEELQGIKTGYIEGLYVAPSHRSTDLVRRFLRESEKWALEQGCSAFASDRSDRVITHRKFAGSAV " 3309 DELETE ampS penam; antibiotic inactivation; cephalosporin; ampC-type beta-lactamase; N/A N/A 3638 ADD LEN-39 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3639 ADD LEN-40 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3636 ADD LEN-34 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3637 ADD LEN-38 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3634 ADD LEN-30 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3635 ADD LEN-32 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3633 ADD OXA-724 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; N/A N/A 3645 ADD LEN-58 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3644 ADD LEN-55 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3643 ADD LEN-51 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3642 ADD LEN-43 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3641 ADD LEN-42 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A 3640 ADD LEN-41 penam; LEN beta-lactamase; antibiotic inactivation; penem; N/A N/A