Model_id Action ARO_name ARO_category Changes To Summary 3593 UPDATE FRI-2 FRI beta-lactamase; penam; antibiotic inactivation; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGTTTTTTTTTAAAAAAAGCGCAAGTACATTTATTTTTTTTCTCTGTCTTCCATTGAACTCATTCGCCTCTCAGGAAAGTAATAGTATTGAGCAAATGAGGGAATTGGAAGCTTCTTTTGGGGGGCGGATAGGTGTTTATATTTTAAACACAAAAAATGGGAAAGAATTTTCCTACAGACAAGATGAGAGATTTCCTTTATGTAGTTCATTTAAGGCATTCCTCGCTGCATCCGTATTAAAAAAAACTCAGGATAAATCTGTTTCTCTTGATGATATGATGGAATATTCTGGACGTGTTATGGAAAAGCATTCTCCTGTGTCAGAAAAATACCGCAAAACAGGAGCAAGCGTGCGGACTTTGGCGAAGGCAGCAATTCAGTACAGTGACAATGGAGCTTCTAATCTATTAATGGAAAGATACATAGGAGGTCCTGAGGGTTTGACTGCATTTATGCGGTCAACGGGAGACACTGACTTCAGGCTTGATCGTTGGGAATTAGAATTAAACTCAGCTATTCCAGGCGATGAACGAGATACTTCAACTCCAAAAGCAGTGGCAATGAGCCTTAAAAATATTGCTTTTGGTTCAGTACTCGATGCTAAAAATAAATCATTGCTGCAGGAATGGCTTAAAGGCAACACTACTGGTAATGCGCGAATTAGAGCTGCGGTTCCAGATAAGTGGGATGTCGGCGATAAAACAGGCACCTGTGGTTTTTATGGTACAGCCAATGATGTTGCTATTTTATGGCCAGACGCTAATTCACCTGCAGTTATGGCTGTCTACACAACACGTCCTAATCAAAACGACAAACATGACGAAGCAGTAATTAAAGATTCTGCAAAAATAGCTATAAATGCAGTGTATGGAAGTTATAAATAA UPDATED fmax with 885 UPDATED accession with KX620467.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterobacter asburiae UPDATED NCBI_taxonomy_id with 61645 UPDATED NCBI_taxonomy_cvterm_id with 36926 UPDATED accession with ANZ90381.1 UPDATED sequence with MFFFKKSASTFIFFLCLPLNSFASQESNSIEQMRELEASFGGRIGVYILNTKNGKEFSYRQDERFPLCSSFKAFLAASVLKKTQDKSVSLDDMMEYSGRVMEKHSPVSEKYRKTGASVRTLAKAAIQYSDNGASNLLMERYIGGPEGLTAFMRSTGDTDFRLDRWELELNSAIPGDERDTSTPKAVAMSLKNIAFGSVLDAKNKSLLQEWLKGNTTGNARIRAAVPDKWDVGDKTGTCGFYGTANDVAILWPDANSPAVMAVYTTRPNQNDKHDEAVIKDSAKIAINAVYGSYK " 3629 UPDATE Neisseria gonorrhoea PBP1 conferring resistance to beta-lactam penam; cephamycin; cephalosporin; penicillin; antibiotic target alteration; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ARO_name "UPDATED ARO_name with Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam " 627 UPDATE Escherichia coli rpoB mutants conferring resistance to rifampicin rifampin; rifapentine; rifabutin; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); antibiotic target replacement; antibiotic target alteration; rifaximin; rifamycin antibiotic; model_param "UPDATED 9917 with S531fs UPDATED param_type_id with 40494 UPDATED param_type with frameshift mutation UPDATED param_description with A frameshift is a type of genetic mutation caused by a nucleotide insertion or deletion that does not equal 3 bases. This changes the grouping of codons and thus the reading frame during translation, resulting in an incomplete or inactive protein product. Many frameshift mutations generate downstream STOP codons, resulting in premature peptide translation termination. Frameshifts may also confer antibiotic resistance through partial or total protein loss-of-function. Frameshift mutations are included with relevant models when applicable, with the following notation: [wild-type AA][position]fs;[[wild-type AA][position]STOP], where AA is an amino acid. If the premature STOP codon position is unknown or does not exist, [wild-type AA][position]fs is sufficient. Termination can also be denoted as: Ter[position]fs. This parameter is currently not included in detection algorithms. " 2865 UPDATE PDC-86 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCTTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCGCTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCAAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA UPDATED fmax with 90021 UPDATED accession with LLSH01000109.1 UPDATED fmin with 88827 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with KSN86152.1 UPDATED sequence with MRDTRFPCLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR " 571 UPDATE clbA dalfopristin; thiamphenicol; oxazolidinone antibiotic; pristinamycin IIA; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with oxazolidinone antibiotic UPDATED category_aro_cvterm_id with 36218 UPDATED category_aro_accession with 3000079 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. " 196 UPDATE Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol antibiotic target alteration; polyamine antibiotic; ethambutol; ethambutol resistant embB; model_param "UPDATED param_type with no association with resistance TB UPDATED param_type with indeterminate confidence TB UPDATED param_type with high confidence TB UPDATED param_type with minimal confidence TB UPDATED param_type with moderate confidence TB " 3649 UPDATE Neisseria gonorrhoea mtrR with mutation conferring resistance antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; azithromycin; erythromycin; ARO_name "UPDATED ARO_name with Neisseria gonorrhoeae mtrR with mutation conferring resistance " 2109 UPDATE Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolone fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; model_param; ARO_name "UPDATED param_type with high confidence TB UPDATED param_type with indeterminate confidence TB UPDATED param_type with no association with resistance TB UPDATED param_type with minimal confidence TB UPDATED param_type with moderate confidence TB UPDATED ARO_name with Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones " 1203 UPDATE Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid isoniazid; antibiotic target alteration; antibiotic resistant ndh; model_param "UPDATED param_type with indeterminate confidence TB UPDATED param_type with high confidence TB UPDATED param_type with minimal confidence TB UPDATED param_type with no association with resistance TB " 3631 UPDATE Neisseria gonorrhoea pilQ gene conferring resistance to beta-lactam penam; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; cephamycin; ceftriaxone; ARO_name "UPDATED ARO_name with Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam " 1876 UPDATE LEN-7 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCAGGGGTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCGCTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 154350 UPDATED accession with CXPA01000063.1 UPDATED fmin with 153489 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella variicola UPDATED NCBI_taxonomy_id with 244366 UPDATED NCBI_taxonomy_cvterm_id with 42612 UPDATED accession with CTQ11867.1 UPDATED sequence with MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGVEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR " 2271 UPDATE Staphylococcus mupB conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); antibiotic target alteration; mupirocin; ARO_name "UPDATED ARO_name with Staphylococcus aureus mupB conferring resistance to mupirocin " 3076 UPDATE dfrB4 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAATGAAGGAAAAAATGAGGTCAGTACTTCAGCTGCTGGCCGGTTCGCATTCCCATCAAACGCCACGTTTGCCTTGGGGGATCGCGTACGCAAGAAGTCTGGCGCTGCTTGGCAGGGGCGCATTGTCGGGTGGTACTGCACAACACTTACCCCTGAAGGCTACGCCGTCGAGTCCGAATCTCACCCAGACTCAGTCCAGATTTATCCCATGACTGCGCTTGAACGGGTGGCCTGA UPDATED fmax with 401 UPDATED accession with EU339233.1 UPDATED fmin with 164 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ABY55281.1 UPDATED sequence with MNEGKNEVSTSAAGRFAFPSNATFALGDRVRKKSGAAWQGRIVGWYCTTLTPEGYAVESESHPDSVQIYPMTALERVA " 3268 UPDATE Clostridioides difficile gyrB conferring resistance to fluoroquinolone antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrB; ARO_name "UPDATED ARO_name with Clostridioides difficile gyrB conferring resistance to fluoroquinolones " 489 UPDATE Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin antibiotic target alteration; streptomycin; aminoglycoside antibiotic; antibiotic resistant gidB; model_param "UPDATED param_type with minimal confidence TB UPDATED param_type with high confidence TB UPDATED 9962 with L79S UPDATED 9962 with L79S UPDATED param_type with no association with resistance TB " 212 UPDATE Staphylococcus aureus parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Staphylococcus aureus parC conferring resistance to fluoroquinolones " 2800 UPDATE cfrC florfenicol; oxazolidinone antibiotic; antibiotic target alteration; streptogramin antibiotic; chloramphenicol; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; lincosamide antibiotic; ARO_category "UPDATED category_aro_name with oxazolidinone antibiotic UPDATED category_aro_cvterm_id with 36218 UPDATED category_aro_accession with 3000079 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. UPDATED category_aro_name with lincosamide antibiotic UPDATED category_aro_cvterm_id with 35936 UPDATED category_aro_accession with 0000017 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides. UPDATED category_aro_name with streptogramin antibiotic UPDATED category_aro_cvterm_id with 35945 UPDATED category_aro_accession with 0000026 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30. " 3651 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to capreomycin antibiotic target alteration; capreomycin; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; model_param "UPDATED param_type with high confidence TB UPDATED param_type with moderate confidence TB " 24 UPDATE fusB fusidic acid; antibiotic target protection; Target protecting FusB-type protein conferring resistance to Fusidic acid; ARO_description; ARO_category "UPDATED ARO_description with FusB encodes a 2-domain zinc-binding protein that binds the ribosomal translocase EF-G, causing it to dissociate from the ribosome. This action increases the ribosomal turnover rate and confers resistance to fusidic acid. This protein is considered a FusB-type protein. DELETED 36000 UPDATED category_aro_name with Target protecting FusB-type protein conferring resistance to Fusidic acid UPDATED category_aro_cvterm_id with 43297 UPDATED category_aro_accession with 3005086 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. UPDATED category_aro_name with antibiotic target protection UPDATED category_aro_cvterm_id with 35999 UPDATED category_aro_accession with 0001003 UPDATED category_aro_class_name with Resistance Mechanism UPDATED category_aro_description with Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance. " 3348 UPDATE cfr(B) chloramphenicol; linezolid; oxazolidinone antibiotic; antibiotic target alteration; streptogramin antibiotic; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; lincosamide antibiotic; ARO_category "UPDATED category_aro_name with streptogramin antibiotic UPDATED category_aro_cvterm_id with 35945 UPDATED category_aro_accession with 0000026 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30. " 1710 UPDATE Mycobacterium leprae gyrB conferring resistance to fluoroquinolone fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Mycobacterium leprae gyrB conferring resistance to fluoroquinolones " 696 UPDATE cfrA dalfopristin; thiamphenicol; oxazolidinone antibiotic; pristinamycin IIA; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with oxazolidinone antibiotic UPDATED category_aro_cvterm_id with 36218 UPDATED category_aro_accession with 3000079 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. " 851 UPDATE Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide antibiotic target alteration; pyrazinamide resistant pncA; pyrazinamide; model_param "UPDATED param_type with no association with resistance TB UPDATED param_type with minimal confidence TB UPDATED param_type with moderate confidence TB UPDATED 9923 with L182S UPDATED 9924 with E174G UPDATED 9940 with V9A UPDATED 9928 with R157W UPDATED 9939 with G17S UPDATED 9926 with A161G UPDATED 9927 with V157G UPDATED 9932 with C138W UPDATED 9931 with R140G UPDATED 9930 with T100P UPDATED 9937 with H57Q UPDATED 9925 with L72P UPDATED 9935 with S164P UPDATED 9934 with K96M UPDATED 9923 with L182S UPDATED 9924 with E174G UPDATED 9940 with V9A UPDATED 9928 with R157W UPDATED 9939 with G17S UPDATED 9926 with A161G UPDATED 9927 with V157G UPDATED 9932 with C138W UPDATED 9931 with R140G UPDATED 9930 with T100P UPDATED 9937 with H57Q UPDATED 9925 with L72P UPDATED 9935 with S164P UPDATED 9934 with K96M UPDATED 9938 with D63Y,T142K UPDATED param_type with high confidence TB UPDATED 9933 with Q122STOP " 1812 UPDATE KHM-1 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; KHM beta-lactamase; ARO_category "UPDATED category_aro_name with KHM beta-lactamase UPDATED category_aro_description with KHM beta-lactamases are Class B beta-lactamases that can confer resistance to all classes of beta-lactams, except the monobactams. " 2131 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin antibiotic target alteration; streptomycin; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; model_param "UPDATED param_type with moderate confidence TB UPDATED param_type with no association with resistance TB UPDATED param_type with high confidence TB " 3364 UPDATE FusF fusidic acid; antibiotic target protection; Target protecting FusB-type protein conferring resistance to Fusidic acid; ARO_description; ARO_category "UPDATED ARO_description with A fusidic acid resistance determinant in Staphylococcus cohnii. This protein behaves akin to FusB as it is a FusB-type protein. It mediates dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. DELETED 36000 UPDATED category_aro_name with Target protecting FusB-type protein conferring resistance to Fusidic acid UPDATED category_aro_cvterm_id with 43297 UPDATED category_aro_accession with 3005086 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. UPDATED category_aro_name with antibiotic target protection UPDATED category_aro_cvterm_id with 35999 UPDATED category_aro_accession with 0001003 UPDATED category_aro_class_name with Resistance Mechanism UPDATED category_aro_description with Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance. " 1943 UPDATE Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid isoniazid; antibiotic target alteration; antibiotic resistant kasA; model_param "UPDATED param_type with no association with resistance TB " 2250 UPDATE fusC fusidic acid; antibiotic target protection; Target protecting FusB-type protein conferring resistance to Fusidic acid; ARO_description; ARO_category "UPDATED ARO_description with FusC is a fusidic acid resistance gene enabling ribosomal translocase EF-G dissociation from the ribosome that has been detected in Staphylococcus aureus and Staphylococcus intermedius. Its mechanism is believed to be similar to fusB due to its high level of sequence homology. It is considered a FusB-type protein. DELETED 36000 UPDATED category_aro_name with Target protecting FusB-type protein conferring resistance to Fusidic acid UPDATED category_aro_cvterm_id with 43297 UPDATED category_aro_accession with 3005086 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. UPDATED category_aro_name with antibiotic target protection UPDATED category_aro_cvterm_id with 35999 UPDATED category_aro_accession with 0001003 UPDATED category_aro_class_name with Resistance Mechanism UPDATED category_aro_description with Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance. " 1947 UPDATE CTX-M-160 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATGAGAAAAAGCGTAAGGCGGGCGATGTTAATGACGACAGCCTGTGTTTCGCTGCTGTTGGCCAGTGTGCCGCTGTGTGCCCAGGCGAACGATGTTCAACAAAAGCTCGCGGCGCTGGAGAAAAGCAGCGGGGGACGACTGGGTGTGGCGTTGATTAACACCGCCGATAACACGCAGACGCTCTACCGCGCCGACGAGCGTTTTGCCATGTGCAGCACCAGTAAAGTGATGGCGGTAGCGGCGGTGCTTAAGCAAAGTGAAACGCAAAAGGGCTTGTTGAGTCAGCGGGTTGAAATTAAGCCCTCAGACTTGGTTAACTACAACCCCATTGCGGAAAAACACGTCAATGGCACGATGACATTCGGGGAGTTGAGCGCGGCGGCGCTACAGTACAGCGATAATACTGCCATGAATAAGCTGATTGCCCATCTCGGGGGGCCGGATAAAGTGACGGCATTTGCCCGTACGATTGGCGATGACACGTTCCGGCTCGATCGTACCGAGCCGACGCTCAACACCGCGATCCCCGGCGACCCGCGCGATACCACCACGCCGTTAGCGATGGCGCAGGCTCTGCGCAATCTGACGTTGGGCAATGCCCTGGGTGACACTCAGCGTGCGCAGCTGGTGATGTGGCTGAAAGGCAACACCACCGGCGCTGCCAGCATTCAGGCAGGGCTACCCACATCGTGGGTTGTCGGGGATAAAACCGGCAGCGGCGGTTATGGTACGACGAATGATATCGCGGTTATTTGGCCGGAAGGTCGCGCGCCGCTCGTTCTGGTGACTTACTTCACCCAGTCGGAGCCGAAGGCAGAGAGCCGTCGTGACGTGCTCGCTGCTGCCGCCAGAATTGTCACCGACGGTTATTAA UPDATED fmax with 876 UPDATED accession with KP050493.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Proteus mirabilis UPDATED NCBI_taxonomy_id with 584 UPDATED NCBI_taxonomy_cvterm_id with 36771 UPDATED accession with AJO16046.1 UPDATED sequence with MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEIKPSDLVNYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY " 1197 UPDATE Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin antibiotic target alteration; antibiotic-resistant rpsL; streptomycin; aminoglycoside antibiotic; model_param "UPDATED param_type with high confidence TB " 1696 UPDATE Salmonella serovars gyrB conferring resistance to fluoroquinolone fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Salmonella serovars gyrB conferring resistance to fluoroquinolones " 127 UPDATE clbB dalfopristin; thiamphenicol; oxazolidinone antibiotic; pristinamycin IIA; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with oxazolidinone antibiotic UPDATED category_aro_cvterm_id with 36218 UPDATED category_aro_accession with 3000079 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. " 2405 UPDATE Neisseria gonorrhoeae parC conferring resistance to fluoroquinolone antibiotic target alteration; fluoroquinolone resistant parC; fluoroquinolone antibiotic; ciprofloxacin; ARO_name "UPDATED ARO_name with Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones " 2248 UPDATE fusD fusidic acid; antibiotic target protection; Target protecting FusB-type protein conferring resistance to Fusidic acid; ARO_description; ARO_category "UPDATED ARO_description with A specific fusidic acid resistance gene conferring intrinsic resistance in the bacteria Staphylococcus saprophyticus. FusD behaves by causing dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. It is considered a FusB-type protein. DELETED 36000 UPDATED category_aro_name with Target protecting FusB-type protein conferring resistance to Fusidic acid UPDATED category_aro_cvterm_id with 43297 UPDATED category_aro_accession with 3005086 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. UPDATED category_aro_name with antibiotic target protection UPDATED category_aro_cvterm_id with 35999 UPDATED category_aro_accession with 0001003 UPDATED category_aro_class_name with Resistance Mechanism UPDATED category_aro_description with Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance. " 2386 UPDATE cipA dalfopristin; thiamphenicol; oxazolidinone antibiotic; pristinamycin IIA; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with oxazolidinone antibiotic UPDATED category_aro_cvterm_id with 36218 UPDATED category_aro_accession with 3000079 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. " 1562 UPDATE aad(6) antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); ARO_description "UPDATED ARO_description with ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis " 2070 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin antibiotic target alteration; amikacin; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; model_param "UPDATED param_type with high confidence TB UPDATED param_type with no association with resistance TB UPDATED param_type with moderate confidence TB " 1935 UPDATE Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; fluoroquinolone resistant gyrA; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; model_param "UPDATED param_type with no association with resistance TB UPDATED param_type with high confidence TB UPDATED param_type with moderate confidence TB " 912 UPDATE LEN-13 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGCTCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 2842857 UPDATED accession with CP001891.1 UPDATED fmin with 2841996 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella variicola At-22 UPDATED NCBI_taxonomy_id with 640131 UPDATED NCBI_taxonomy_cvterm_id with 43310 UPDATED accession with ADC58623.1 UPDATED sequence with MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVLYLRDTPASMAERNQHIAGIGAALIEHWQR " 2859 UPDATE PDC-80 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGGAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCACTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA UPDATED fmax with 1194 UPDATED accession with KX354370.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with ANJ78206.1 UPDATED sequence with MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAGGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR " 1176 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid isoniazid; isoniazid resistant katG; antibiotic target alteration; model_param "UPDATED param_type with indeterminate confidence TB UPDATED param_type with high confidence TB UPDATED param_type with minimal confidence TB " 1237 UPDATE Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin rifampin; rifapentine; rifabutin; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); antibiotic target replacement; antibiotic target alteration; rifaximin; rifamycin antibiotic; model_param "UPDATED param_type with no association with resistance TB UPDATED param_type with indeterminate confidence TB UPDATED param_type with high confidence TB UPDATED param_type with minimal confidence TB UPDATED param_type with moderate confidence TB " 1339 UPDATE Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol antibiotic target alteration; ethambutol resistant embR; ethambutol; polyamine antibiotic; model_param "UPDATED param_type with no association with resistance TB " 143 UPDATE cphA7 carbapenem; CphA beta-lactamase; antibiotic inactivation; model_sequences; model_param "UPDATED partial with 0 UPDATED sequence with ATGATGAAAGGTTGGATGAAATGCGGATTGGCCGGAGCCGTGGTGCTGATGGCGAGTTTTTGGGGCGGCAGCGTGCGGGCGGCGGGGATCTCCCTCAAGCAGGTGAGCGGCCCTGTCTATGTGGTGGAGGATAACTACTACGTCAAAGAGAACTCCATGGTCTATTTCGGGGCCAAGGGGGTGACTGCGGTGGGGGCGACCTGGACGCCGGATACCGCCCGCGAGTTGCACAAGCTGATCAAACGGGTCAGCAGCAAGCCGGTGCTGGAGGTGATCAACACCAACTACCACACCGATCGGGCGGGCGGTAACGCCTACTGGAAGTCCATCGGGGCCAAGGTGGTGGCGACGCGCCAGACCCGGGATCTGATGAAGAGCGACTGGGCCGAGATTGTTGCCTTTACCCGCAAGGGGCTGCCGGAGTACCCGGATCTGCCGCTGGTGCTGCCGAACGTGGTGCACGATGGCGACTTCAAGCTGCAAGATGGCAAGGTGCGTGCCTTCTATGCGGGCCCGGCCCACACGCCGGACGGCATCTTTGTCTACTTCCCCGACGAGCAGGTGCTCTATGGCAACTGCATCCTCAAGGAGAAGCTGGGCAACCTGAGCTTTGCCAATGTGAAGGAGTATCCGCAGACCATCGAGCGGCTCAAGGCGATGAAGTTGCCGATCAAGACGGTGATCGGCGGTCACGACTCACCGCTGCACGGCCCCGAGCTGATTGATCACTACGAAGCGCTGATCAAGGCCGCTGCTCATTCATAA UPDATED fmax with 765 UPDATED accession with AY227053.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Aeromonas jandaei UPDATED NCBI_taxonomy_id with 650 UPDATED NCBI_taxonomy_cvterm_id with 42604 UPDATED accession with AAP69915.1 UPDATED sequence with MMKGWMKCGLAGAVVLMASFWGGSVRAAGISLKQVSGPVYVVEDNYYVKENSMVYFGAKGVTAVGATWTPDTARELHKLIKRVSSKPVLEVINTNYHTDRAGGNAYWKSIGAKVVATRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFKLQDGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFANVKEYPQTIERLKAMKLPIKTVIGGHDSPLHGPELIDHYEALIKAAAHS UPDATED param_value with 500 " 1267 UPDATE QnrB40 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGACTCTGGCATTAGTTGGCGAAAAAATTGACAGAAATCGCTTCACTGGTGAGAAAGTTGAAAATAGTACATTTTTTAACTGCGATTTTTCAGGTGCCGACCTGAGCGGCACTGAATTTATCGGCTGCCAGTTCTATGATCGCGAAAGTCAGAAAGGATGCAATTTTAGTCGCGCAATGCTGAGAGATGCCATTTTCAAAAGCTGTGATTTATCAATGGCAGATTTCCGCAACGTCAGCGCATTGGGCATTGAAATTCGCCACTGCCGCGCACAAGGCGCAGATTTCCGCGGTGCAAGCTTTATGAATATGATCACCACGCGCACCTGGTTTTGCAGCGCATATATCACTAATACCAATCTAAGCTACGCCAATTTTTCGAAAGTCGTGTTGGAAAAGTGTGAGCTATGGGAAAACCGCTGGATGGGGACTCAGGTACTGGGTACGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCGACTTTCGACTGGCGAGCAGCAAACTTCACACATTGCGATCTGACCAATTCGGAGTTAGGTGACTTAGATATTCGGGGTGTTGATTTACAAGGCGTTAAGTTAGACAACTACCAGGCATCGTTGCTCATGGAGCGGCTTGGCATCGCTGTGATTGGTTAG UPDATED fmax with 660 UPDATED accession with NG_050503.1 UPDATED fmin with 15 UPDATED strand with + UPDATED NCBI_taxonomy_name with Citrobacter braakii UPDATED NCBI_taxonomy_id with 57706 UPDATED NCBI_taxonomy_cvterm_id with 39584 UPDATED accession with WP_063866081.1 UPDATED sequence with MTLALVGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLRDAIFKSCDLSMADFRNVSALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGTQVLGTTFSGSDLSGGEFSTFDWRAANFTHCDLTNSELGDLDIRGVDLQGVKLDNYQASLLMERLGIAVIG " 2853 UPDATE PDC-74 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGTCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA UPDATED fmax with 1294 UPDATED accession with NG_051744.1 UPDATED fmin with 100 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with WP_040184286.1 UPDATED sequence with MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR " 3745 UPDATE Mycobacterium tuberculosis 23S rRNA mutation conferring resistance to capreomycin antibiotic target alteration; capreomycin; aminoglycoside antibiotic; 23s rRNA with mutation conferring resistance to aminoglycoside antibiotics; model_param "UPDATED param_type with no association with resistance TB " 329 UPDATE CTX-M-159 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGGTGACAAAGAGAGTGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTGCTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCGCAGATAATACGCAGGTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCAAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATGACGCTGGCAAAACTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGTGGGTGATAAGACCGGCAGCGGCGGCTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTGGTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTGGCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA UPDATED fmax with 1011 UPDATED accession with AB976602.1 UPDATED fmin with 135 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with BAP18874.1 UPDATED sequence with MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAKLSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL " 1354 UPDATE Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol ethambutol resistant embA; antibiotic target alteration; ethambutol; polyamine antibiotic; model_param "UPDATED param_type with high confidence TB UPDATED param_type with no association with resistance TB UPDATED param_type with moderate confidence TB " 3403 UPDATE Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide antibiotic target alteration; pyrazinamide resistant rpsA; pyrazinamide; model_param "UPDATED param_type with high confidence TB " 2132 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin kanamycin A; antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; model_param "UPDATED param_type with high confidence TB UPDATED param_type with minimal confidence TB " 386 UPDATE LEN-8 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGTGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGCCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCATCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 8215 UPDATED accession with CEGG01000030.1 UPDATED fmin with 7354 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella variicola UPDATED NCBI_taxonomy_id with 244366 UPDATED NCBI_taxonomy_cvterm_id with 42612 UPDATED accession with CEP30258.1 UPDATED sequence with MRYVRLCVISLLATLPLVVYAGPQPLEQIKQSESQLPGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTHLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR " 1592 UPDATE dfrA14 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED partial with 0 UPDATED sequence with TTGAAAGTATCATTGATGGCTGCGAAAGCGAAAAACGGCGTGATTGGTTGCGGTCCAGACATACCCTGGTCCGCGAAAGGGGAGCAGCTACTTTTTAAAGCATTGACCTACAATCAGTGGCTTCTGGTGGGTCGCAAGACGTTTGAATCTATGGGCGCACTCCCCAATAGGAAATACGCGGTCGTTACCCGCTCAGGTTGGACATCAAATGATGACAATGTAGTTGTATTTCAGTCAATCGAAGAGGCCATGGACAGGCTAGCTGAATTCACCGGTCACGTTATAGTGTCTGGTGGCGGAGAAATTTACCGAGAAACATTACCCATGGCCTCTACGCTCCACTTATCGACGATCGACATCGAGCCAGAGGGGGATGTTTTCTTCCCGAGTATTCCAAATACCTTCGAAGTTGTTTTTGAGCAACACTTTACTTCAAACATTAACTATTGCTATCAAATTTGGAAAAAGGGTTAA UPDATED fmax with 1091 UPDATED accession with KF921535.1 UPDATED fmin with 617 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AHK10285.1 UPDATED sequence with MKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDIEPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG " 2278 UPDATE Bifidobacterium ileS conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); antibiotic target alteration; mupirocin; ARO_name "UPDATED ARO_name with Bifidobacterium bifidum ileS conferring resistance to mupirocin " 3646 UPDATE Neisseria gonorrhoea 23S rRNA with mutation conferring resistance to azithromycin antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; azithromycin; ARO_name "UPDATED ARO_name with Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin " 100 UPDATE Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide antibiotic target alteration; ethionamide; ethionamide resistant ethA; model_param "UPDATED param_type with high confidence TB UPDATED param_type with no association with resistance TB " 660 UPDATE Streptococcus pneumoniae parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Streptococcus pneumoniae parC conferring resistance to fluoroquinolones " 1849 UPDATE Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides antibiotic target alteration; capreomycin; streptomycin; aminoglycoside antibiotic; Antibiotic resistant tlyA; model_param "UPDATED param_type with high confidence TB " 1432 UPDATE Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol ethambutol resistant embC; antibiotic target alteration; ethambutol; polyamine antibiotic; model_param "UPDATED param_type with no association with resistance TB UPDATED param_type with moderate confidence TB " 2270 UPDATE Staphylococcus mupA conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); antibiotic target alteration; mupirocin; ARO_name "UPDATED ARO_name with Staphylococcus aureus mupA conferring resistance to mupirocin " 2215 UPDATE Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolone antibiotic target alteration; fluoroquinolone resistant parC; fluoroquinolone antibiotic; ARO_name "UPDATED ARO_name with Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones " 1642 UPDATE clbC dalfopristin; thiamphenicol; oxazolidinone antibiotic; pristinamycin IIA; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with oxazolidinone antibiotic UPDATED category_aro_cvterm_id with 36218 UPDATED category_aro_accession with 3000079 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. " 2083 UPDATE Mycoplasma hominis parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Mycoplasma hominis parC conferring resistance to fluoroquinolones " 2315 UPDATE Acinetobacter baumannii parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Acinetobacter baumannii parC conferring resistance to fluoroquinolones " 2235 UPDATE SPG-1 carbapenem; SPG beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_name with SPG beta-lactamase " 36 UPDATE Mycobaterium leprae gyrA conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; fluoroquinolone resistant gyrA; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; ARO_name "UPDATED ARO_description with Point mutation of Mycobacterium leprae gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. UPDATED ARO_name with Mycobacterium leprae gyrA conferring resistance to fluoroquinolones " 1731 UPDATE mphB antibiotic inactivation; macrolide phosphotransferase (MPH); oleandomycin; dirithromycin; macrolide antibiotic; telithromycin; azithromycin; roxithromycin; spiramycin; clarithromycin; tylosin; erythromycin; model_sequences; model_param "UPDATED partial with 0 UPDATED sequence with ATGAGTAAAGATATTAAACAAGTAATCGAGATAGCAAAAAAACACAATCTTTTTCTAAAAGAAGAAACGATACAGTTTAATGAATCAGGGCTTGATTTTCAAGCTGTTTTTGCACAAGATAATAATGGAATTGATTGGGTTCTAAGATTGCCTAGACGGGAAGATGTGATGCCTAGAACAAAGGTAGAAAAACAAGCTTTGGATTTGGTAAATAAGTACGCTATATCCTTTCAGGCACCAAACTGGATCATTTACACAGAGGAACTAATAGCTTATAAAAAGTTAGATGGTGTGCCAGCAGGTACGATAGATCATAACATAGGTAACTATATTTGGGAGATAGACATAAATAATGTTCCAGAATTATTTCACAAGTCGCTAGGCAGGGTGTTAGCAGAGCTTCATAGCATACCTAGTAATAAAGCCGCAGCGCTTGATCTTGTAGTACACACACCAGAAGAAGCAAGAATGTCAATGAAGCAGCGTATGGATGCAGTAAGAGCAAAGTTCGGAGTAGGTGAGAATCTATGGAACAGATGGCAAGCGTGGTTGAATGATGATGATATGTGGCCTAAGAAAACTGGACTGATTCATGGAGATGTACATGCCGGACATACTATGATTGATAAGGATGCCAATGTGACTGGATTAATCGATTGGACTGAAGCGAAGGTTACAGATGTTTCGCATGACTTTATTTTCAACTATAGAGCTTTTGGGGAAGAAGGGTTAGAAGCTTTAATTCTCGCTTATAAGGAAATTGGTGGATATTACTGGCCTAAAATGAAAGAGCATATTATCGAACTTAATGCAGCATACCCAGTTTCAATCGCTGAGTTTGCATTAGTGTCTGGAATTGAGGAATATGAGCAGATGGCAAAGGAAGCATTGGAAGTACAAGGTTCGTAA UPDATED fmax with 2067 UPDATED accession with D85892.1 UPDATED fmin with 1158 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with BAA12910.1 UPDATED sequence with MSKDIKQVIEIAKKHNLFLKEETIQFNESGLDFQAVFAQDNNGIDWVLRLPRREDVMPRTKVEKQALDLVNKYAISFQAPNWIIYTEELIAYKKLDGVPAGTIDHNIGNYIWEIDINNVPELFHKSLGRVLAELHSIPSNKAAALDLVVHTPEEARMSMKQRMDAVRAKFGVGENLWNRWQAWLNDDDMWPKKTGLIHGDVHAGHTMIDKDANVTGLIDWTEAKVTDVSHDFIFNYRAFGEEGLEALILAYKEIGGYYWPKMKEHIIELNAAYPVSIAEFALVSGIEEYEQMAKEALEVQGS UPDATED param_value with 600 " 535 UPDATE Morganella morganii gyrB conferring resistance to fluoroquinolone fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Morganella morganii gyrB conferring resistance to fluoroquinolones " 1450 UPDATE Escherichia coli parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Escherichia coli parC conferring resistance to fluoroquinolones " 1965 UPDATE LEN-11 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 121152 UPDATED accession with FLES01000010.1 UPDATED fmin with 120291 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella variicola UPDATED NCBI_taxonomy_id with 244366 UPDATED NCBI_taxonomy_cvterm_id with 42612 UPDATED accession with SAU22663.1 UPDATED sequence with MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR " 1386 UPDATE ANT(9)-Ia antibiotic inactivation; aminoglycoside antibiotic; spectinomycin; ANT(9); model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAGCAATTTGATTAACGGAAAAATACCAAATCAAGCGATTCAAACATTAAAAATCGTAAAAGATTTATTTGGAAGTTCAATAGTTGGAGTATATCTATTTGGTTCAGCAGTAAATGGTGGTTTACGCATTAACAGCGATGTAGATGTTCTAGTCGTCGTGAATCATAGTTTACCTCAATTAACTCGAAAAAAACTAACAGAAAGACTAATGACTATATCAGGAAAGATTGGAAATACGGATTCTGTTAGACCACTTGAAGTTACGGTTATAAATAGGAGTGAAGTTGTCCCTTGGCAATATCCTCCAAAAAGAGAATTTATATACGGTGAGTGGCTCAGGGGTGAATTTGAGAATGGACAAATTCAGGAACCAAGCTATGATCCTGATTTGGCTATTGTTTTAGCACAAGCAAGAAAGAATAGTATTTCTCTATTTGGTCCTGATTCTTCAAGTATACTTGTCTCCGTACCTTTGACAGATATTCGAAGAGCAATTAAGGATTCTTTGCCAGAACTAATTGAGGGGATAAAAGGTGATGAGCGTAATGTAATTTTAACCCTAGCTCGAATGTGGCAAACAGTGACTACTGGTGAAATTACCTCGAAAGATGTCGCTGCAGAATGGGCTATACCTCTTTTACCTAAAGAGCATGTAACTTTACTGGATATAGCTAGAAAAGGCTATCGGGGAGAGTGTGATGATAAGTGGGAAGGACTATATTCAAAGGTGAAAGCACTCGTTAAGTATATGAAAAATTCTATAGAAACTTCTCTCAATTAG UPDATED fmax with 1113 UPDATED accession with X02588.1 UPDATED fmin with 330 UPDATED strand with + UPDATED NCBI_taxonomy_name with Staphylococcus aureus UPDATED NCBI_taxonomy_id with 1280 UPDATED NCBI_taxonomy_cvterm_id with 35508 UPDATED accession with CAA26428.1 UPDATED sequence with MSNLINGKIPNQAIQTLKIVKDLFGSSIVGVYLFGSAVNGGLRINSDVDVLVVVNHSLPQLTRKKLTERLMTISGKIGNTDSVRPLEVTVINRSEVVPWQYPPKREFIYGEWLRGEFENGQIQEPSYDPDLAIVLAQARKNSISLFGPDSSSILVSVPLTDIRRAIKDSLPELIEGIKGDERNVILTLARMWQTVTTGEITSKDVAAEWAIPLLPKEHVTLLDIARKGYRGECDDKWEGLYSKVKALVKYMKNSIETSLN " 1574 UPDATE Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid isoniazid; antibiotic target alteration; isoniazid resistant inhA; model_param "UPDATED param_type with indeterminate confidence TB UPDATED param_type with high confidence TB UPDATED param_type with minimal confidence TB UPDATED param_type with moderate confidence TB " 2104 UPDATE Ureaplasma urealyticum parC conferring resistance to fluoroquinolone grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Ureaplasma urealyticum parC conferring resistance to fluoroquinolones " 2148 UPDATE Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolone fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_name "UPDATED ARO_name with Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones " 2292 DELETE Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin clorobiocin; aminocoumarin antibiotic; novobiocin; coumermycin A1; antibiotic target alteration; aminocoumarin resistant parY; N/A N/A 3773 ADD CTX-M-161 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; N/A N/A 3772 ADD FLC-1 FRI beta-lactamase; penam; antibiotic inactivation; N/A N/A 3771 ADD FRI-9 FRI beta-lactamase; penam; antibiotic inactivation; N/A N/A 3770 ADD FRI-8 FRI beta-lactamase; penam; antibiotic inactivation; N/A N/A 3777 ADD CTX-M-165 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; N/A N/A 3776 ADD CTX-M-164 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; N/A N/A 3775 ADD CTX-M-163 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; N/A N/A 3774 ADD CTX-M-162 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; N/A N/A 3751 ADD TEM-181 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3804 ADD cprS pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; N/A N/A 3779 ADD Yrc-1 penam; antibiotic inactivation; cephalosporin; YRC Beta-lactamase; N/A N/A 3778 ADD CTX-M-166 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; N/A N/A 3755 ADD qacEdelta1 efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; antibiotic efflux; N/A N/A 3825 ADD RanA efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; N/A N/A 3757 ADD IDC-2 carbapenem; antibiotic inactivation; cephalosporin; IDC beta-lactamase; N/A N/A 3828 ADD GPC-1 carbapenem; antibiotic inactivation; GPC beta-lactamase; N/A N/A 3807 ADD rsmA antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; trimethoprim; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; fluoroquinolone antibiotic; phenicol antibiotic; chloramphenicol; N/A N/A 3824 ADD RanB efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; N/A N/A 3768 ADD FRI-6 FRI beta-lactamase; penam; antibiotic inactivation; N/A N/A 3806 ADD ParR erythromycin; penem; tetracycline antibiotic; meropenem; antibiotic efflux; imipenem; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; reduced permeability to antibiotic; cephalosporin; carbapenem; gentamicin C; amikacin; aminoglycoside antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; ciprofloxacin; acridine dye; penam; Outer Membrane Porin (Opr); efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; N/A N/A 3823 ADD mef(D) efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; antibiotic efflux; N/A N/A 3822 ADD msrH pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; N/A N/A 3799 ADD LptD efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; N/A N/A 3821 ADD msrF pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; N/A N/A 3795 ADD ArnT pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; N/A N/A 3794 ADD LpsA peptide antibiotic; reduced permeability to antibiotic; Intrinsic peptide antibiotic resistant Lps; N/A N/A 3827 ADD OXA-898 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; N/A N/A 3820 ADD AAC(3)-IIg antibiotic inactivation; AAC(3); aminoglycoside antibiotic; N/A N/A 3791 ADD eptB pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; N/A N/A 3790 ADD MecC-type methicillin resistance repressor MecI penam; methicillin resistant PBP2; antibiotic target replacement; N/A N/A 3793 ADD LpsB peptide antibiotic; reduced permeability to antibiotic; Intrinsic peptide antibiotic resistant Lps; N/A N/A 3792 ADD CrcB efflux pump complex or subunit conferring antibiotic resistance; multidrug and toxic compound extrusion (MATE) transporter; antibiotic efflux; N/A N/A 3805 ADD ParS erythromycin; penem; tetracycline antibiotic; meropenem; antibiotic efflux; imipenem; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; reduced permeability to antibiotic; cephalosporin; carbapenem; gentamicin C; amikacin; aminoglycoside antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; ciprofloxacin; acridine dye; penam; Outer Membrane Porin (Opr); efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; N/A N/A 3769 ADD FRI-7 FRI beta-lactamase; penam; antibiotic inactivation; N/A N/A 3759 ADD APH(3')-VIb antibiotic inactivation; aminoglycoside antibiotic; paromomycin; kanamycin A; APH(3'); isepamicin; gentamicin B; amikacin; ribostamycin; G418; neomycin; butirosin; N/A N/A 3812 ADD ROB-6 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3753 ADD TxR antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; tetracycline; N/A N/A 3760 ADD CMY-150 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3761 ADD LMB-1 carbapenem; penam; LMB beta-lactamase; antibiotic inactivation; cephalosporin; N/A N/A 3762 ADD IMP-68 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A 3811 ADD ROB-5 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3816 ADD ROB-10 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3765 ADD FosL1 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; N/A N/A 3766 ADD FRI-4 FRI beta-lactamase; penam; antibiotic inactivation; N/A N/A 3815 ADD ROB-8 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3826 ADD OXA-899 penam; antibiotic inactivation; cephalosporin; OXA beta-lactamase; N/A N/A 3801 ADD AAC(3)-IVb antibiotic inactivation; AAC(3); aminoglycoside antibiotic; gentamicin A; tobramycin; N/A N/A 3767 ADD FRI-5 FRI beta-lactamase; penam; antibiotic inactivation; N/A N/A 3819 ADD dfrA31 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 3758 ADD VMB-1 carbapenem; VMB beta-lactamase; antibiotic inactivation; N/A N/A 3754 ADD qacE efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; antibiotic efflux; N/A N/A 3817 ADD Thermus thermophilus uL3 mutations conferring resistance to pleuromutilin antibiotics Ribosomal protein mutation conferring resistance to pleuromutilin antibiotics; antibiotic target alteration; pleuromutilin antibiotic; N/A N/A 3800 ADD OXA-837 ampicillin; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 3803 ADD cprR pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; N/A N/A 3813 ADD ROB-7 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3802 ADD ANT(3'')-Ib antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; N/A N/A 3798 ADD Tet(X5) tetracycline antibiotic; antibiotic inactivation; tetracycline inactivation enzyme; N/A N/A 3782 ADD PDC-55 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 3783 ADD YajC penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; N/A N/A 3780 ADD ADC-159 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; N/A N/A 3781 ADD PDC-65 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 3786 ADD cmlA9 efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; antibiotic efflux; N/A N/A 3787 ADD OmpA penam; reduced permeability to antibiotic; penem; carbapenem; cephalosporin; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; N/A N/A 3784 ADD mlaF efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; N/A N/A 3785 ADD mlaD efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; N/A N/A 3818 ADD Thermus thermophilus 23s rRNA conferring resistance to pleuromutilin antibiotics 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics; antibiotic target alteration; pleuromutilin antibiotic; N/A N/A 3788 ADD SatA streptothricin acetyltransferase (SAT); nucleoside antibiotic; antibiotic inactivation; N/A N/A 3789 ADD BLMT glycopeptide antibiotic; antibiotic inactivation; Bleomycin resistant protein; N/A N/A 3808 ADD ROB-2 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3814 ADD ROB-9 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3756 ADD IDC-1 carbapenem; antibiotic inactivation; cephalosporin; IDC beta-lactamase; N/A N/A 3810 ADD ROB-4 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3809 ADD ROB-3 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; N/A N/A 3763 ADD cfr(D) oxazolidinone antibiotic; antibiotic target alteration; streptogramin antibiotic; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; lincosamide antibiotic; N/A N/A 3797 ADD Tet(X6) tetracycline antibiotic; antibiotic inactivation; tetracycline inactivation enzyme; N/A N/A