Model_id Action ARO_name ARO_category Changes To Summary 2713 UPDATE MexXY-OprM erythromycin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and intercalating dyes; acridine dye; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3920 UPDATE CMY-96 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-96 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. UPDATED param_value with 700 " 2711 UPDATE MexXY-OprM erythromycin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and intercalating dyes; acridine dye; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1305 UPDATE OprM sulfonamide antibiotic; tetracycline; erythromycin; penem; panipenem; thiamphenicol; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; ofloxacin; norfloxacin; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; gentamicin C; amikacin; ceftriaxone; disinfecting agents and intercalating dyes; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; acridine dye; diaminopyrimidine antibiotic; ticarcillin; ampicillin; amoxicillin; penam; aminoglycoside antibiotic; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; nalidixic acid; azithromycin; tobramycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1786 UPDATE mexY erythromycin; arbekacin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and intercalating dyes; acridine dye; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2323 UPDATE qacH efflux pump complex or subunit conferring antibiotic resistance; small multidrug resistance (SMR) antibiotic efflux pump; disinfecting agents and intercalating dyes; antibiotic efflux; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2321 UPDATE cdeA antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; multidrug and toxic compound extrusion (MATE) transporter; acridine dye; acriflavine; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 696 UPDATE cfrA dalfopristin; thiamphenicol; oxazolidinone antibiotic; pristinamycin IIA; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_description "UPDATED ARO_description with CfrA is a chloramphenicol-florfenicol resistance gene and methyltransferase enzyme. Methylation of position 8 of A2503 in 23S rRNA confers resistance to chloramphenicol antibiotics first identified by Schwarz 2000 as cfr from Staphylococcus sciuri. Additional Oxazolidinone resistance mediated by the cfr gene in a human isolated was first reported from Colombia in linezolid- and methicillin-resistant Staphylococcus aureus. " 2293 UPDATE Bacillus subtilis pgsA with mutation conferring resistance to daptomycin peptide antibiotic; antibiotic target alteration; daptomycin resistant pgsA; daptomycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAATATTCCGAACCAGATTACGGTTTTTAGAGTAGTGTTAATACCAGTTTTTATATTGTTTGCGTTAGTTGATTTTGGATTTGGCAATGTGTCATTTCTAGGAGGATATGAAATAAGAATTGAGTTATTAATCAGTGGTTTTATTTTTATATTGGCTTCCCTTAGCGATTTTGTTGATGGTTATTTAGCTAGAAAATGGAATTTAGTTACAAATATGGGGAAATTTTTGGATCCATTAGCGGATAAATTATTAGTTGCAAGTGCTTTAATTGTACTTGTGCAACTAGGACTAACAAATTCTGTAGTAGCAATCATTATTATTGCCAGAGAATTTGCCGTAACTGGTTTACGTTTACTACAAATTGAACAAGGATTCGTAAGTGCAGCTGGTCAATTAGGTAAAATTAAAACAGCAGTTACTATGGTAGCAATTACTTGGTTGTTATTAGGTGATCCATTGGCAACATTGATTGGTTTGTCATTAGGACAAATTTTATTATACATTGGCGTTATTTTTACTATCTTATCTGGTATTGAATACTTTTATAAAGGTAGAGATGTTTTTAAACAAAAATAA UPDATED fmax with 1279164 UPDATED accession with BA000033.2 UPDATED fmin with 1278585 UPDATED strand with + UPDATED NCBI_taxonomy_name with Staphylococcus aureus subsp. aureus MW2 UPDATED NCBI_taxonomy_id with 196620 UPDATED NCBI_taxonomy_cvterm_id with 35515 UPDATED accession with BAB95031.1 UPDATED sequence with MNIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIFILASLSDFVDGYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTNSVVAIIIIAREFAVTGLRLLQIEQGFVSAAGQLGKIKTAVTMVAITWLLLGDPLATLIGLSLGQILLYIGVIFTILSGIEYFYKGRDVFKQK " 1317 UPDATE CTX-M-3 penam; antibiotic inactivation; cephalosporin; cefazolin; ceftazidime; cefalotin; cephamycin; amoxicillin; ampicillin; clavulanic acid; cefixime; ceftriaxone; cefoxitin; amoxicillin-clavulanic acid; CTX-M beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with cefazolin UPDATED category_aro_cvterm_id with 35975 UPDATED category_aro_accession with 0000058 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with cephamycin UPDATED category_aro_cvterm_id with 35962 UPDATED category_aro_accession with 0000044 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases. UPDATED category_aro_name with amoxicillin UPDATED category_aro_cvterm_id with 35981 UPDATED category_aro_accession with 0000064 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. UPDATED category_aro_name with clavulanic acid UPDATED category_aro_cvterm_id with 35996 UPDATED category_aro_accession with 0000079 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. UPDATED category_aro_name with cefixime UPDATED category_aro_cvterm_id with 36990 UPDATED category_aro_accession with 3000646 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. UPDATED category_aro_name with cefoxitin UPDATED category_aro_cvterm_id with 35927 UPDATED category_aro_accession with 0000008 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. UPDATED category_aro_name with amoxicillin-clavulanic acid UPDATED category_aro_cvterm_id with 40924 UPDATED category_aro_accession with 3003997 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). " 3830 UPDATE qacL efflux pump complex or subunit conferring antibiotic resistance; small multidrug resistance (SMR) antibiotic efflux pump; disinfecting agents and intercalating dyes; antibiotic efflux; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1344 UPDATE MexH antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; acridine dye; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; tetracycline; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 715 UPDATE PDC-3 penam; carbapenem; monobactam; piperacillin-tazobactam; cephalosporin; cefazolin; ampicillin; ceftazidime; cefalotin; cephamycin; antibiotic inactivation; cefixime; amoxicillin; PDC beta-lactamase; clavulanic acid; piperacillin; tazobactam; ceftriaxone; cefoxitin; amoxicillin-clavulanic acid; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with cefoxitin UPDATED category_aro_cvterm_id with 35927 UPDATED category_aro_accession with 0000008 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. UPDATED category_aro_name with cefazolin UPDATED category_aro_cvterm_id with 35975 UPDATED category_aro_accession with 0000058 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with piperacillin-tazobactam UPDATED category_aro_cvterm_id with 40951 UPDATED category_aro_accession with 3004021 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the penam beta-lactam antibiotic Piperacillin and the beta-lactamase inhibitor Tazobactam. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with cephamycin UPDATED category_aro_cvterm_id with 35962 UPDATED category_aro_accession with 0000044 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases. UPDATED category_aro_name with clavulanic acid UPDATED category_aro_cvterm_id with 35996 UPDATED category_aro_accession with 0000079 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. UPDATED category_aro_name with amoxicillin UPDATED category_aro_cvterm_id with 35981 UPDATED category_aro_accession with 0000064 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. UPDATED category_aro_name with piperacillin UPDATED category_aro_cvterm_id with 35995 UPDATED category_aro_accession with 0000078 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria. UPDATED category_aro_name with tazobactam UPDATED category_aro_cvterm_id with 35994 UPDATED category_aro_accession with 0000077 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Tazobactam is a compound which inhibits the action of bacterial beta-lactamases. UPDATED category_aro_name with ceftriaxone UPDATED category_aro_cvterm_id with 35979 UPDATED category_aro_accession with 0000062 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. UPDATED category_aro_name with cefixime UPDATED category_aro_cvterm_id with 36990 UPDATED category_aro_accession with 3000646 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. UPDATED category_aro_name with amoxicillin-clavulanic acid UPDATED category_aro_cvterm_id with 40924 UPDATED category_aro_accession with 3003997 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). " 1952 UPDATE OXA-1 penam; antibiotic inactivation; cephalosporin; carbapenem; piperacillin-tazobactam; cefalotin; amoxicillin; ampicillin; clavulanic acid; piperacillin; tazobactam; OXA beta-lactamase; amoxicillin-clavulanic acid; ARO_category "UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. UPDATED category_aro_name with clavulanic acid UPDATED category_aro_cvterm_id with 35996 UPDATED category_aro_accession with 0000079 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. UPDATED category_aro_name with amoxicillin-clavulanic acid UPDATED category_aro_cvterm_id with 40924 UPDATED category_aro_accession with 3003997 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). " 1554 UPDATE norA antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; acridine dye; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1825 UPDATE CTX-M-27 penam; carbapenem; antibiotic inactivation; piperacillin-tazobactam; cephalosporin; cefazolin; ceftazidime; cefalotin; amoxicillin-clavulanic acid; amoxicillin; ampicillin; clavulanic acid; piperacillin; tazobactam; cefixime; ertapenem; CTX-M beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with cefazolin UPDATED category_aro_cvterm_id with 35975 UPDATED category_aro_accession with 0000058 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with carbapenem UPDATED category_aro_cvterm_id with 35939 UPDATED category_aro_accession with 0000020 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_name with piperacillin-tazobactam UPDATED category_aro_cvterm_id with 40951 UPDATED category_aro_accession with 3004021 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the penam beta-lactam antibiotic Piperacillin and the beta-lactamase inhibitor Tazobactam. UPDATED category_aro_name with clavulanic acid UPDATED category_aro_cvterm_id with 35996 UPDATED category_aro_accession with 0000079 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. UPDATED category_aro_name with amoxicillin UPDATED category_aro_cvterm_id with 35981 UPDATED category_aro_accession with 0000064 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. UPDATED category_aro_name with piperacillin UPDATED category_aro_cvterm_id with 35995 UPDATED category_aro_accession with 0000078 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria. UPDATED category_aro_name with tazobactam UPDATED category_aro_cvterm_id with 35994 UPDATED category_aro_accession with 0000077 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Tazobactam is a compound which inhibits the action of bacterial beta-lactamases. UPDATED category_aro_name with cefixime UPDATED category_aro_cvterm_id with 36990 UPDATED category_aro_accession with 3000646 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. UPDATED category_aro_name with amoxicillin-clavulanic acid UPDATED category_aro_cvterm_id with 40924 UPDATED category_aro_accession with 3003997 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). UPDATED category_aro_name with ertapenem UPDATED category_aro_cvterm_id with 35987 UPDATED category_aro_accession with 0000070 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis. " 2254 UPDATE Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid antibiotic target alteration; fusidic acid; antibiotic resistant fusA; model_param "UPDATED 10275 with H457L UPDATED 10274 with H457N UPDATED 10275 with H457L UPDATED 10274 with H457N " 2775 UPDATE Pseudomonas aeruginosa soxR antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and intercalating dyes; tigecycline; protein(s) and two-component regulatory system modulating antibiotic efflux; acridine dye; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1256 UPDATE bmr antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and intercalating dyes; acridine dye; puromycin; acriflavine; nucleoside antibiotic; fluoroquinolone antibiotic; phenicol antibiotic; chloramphenicol; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1390 UPDATE arlR antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; acridine dye; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2769 UPDATE MdtNOP antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; acridine dye; puromycin; acriflavine; nucleoside antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 442 UPDATE OpmD antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; acridine dye; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; tetracycline; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2761 UPDATE MexPQ-OpmE kitasamycin; imipenem; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; trimethoprim; macrolide antibiotic; disinfecting agents and intercalating dyes; carbapenem; acridine dye; diaminopyrimidine antibiotic; acriflavine; tetracycline antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2760 UPDATE MexGHI-OpmD antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; acridine dye; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; tetracycline; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1647 UPDATE MexI antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; acridine dye; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; tetracycline; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2056 UPDATE mdtO antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; acridine dye; puromycin; acriflavine; nucleoside antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3805 UPDATE ParS erythromycin; penem; tetracycline antibiotic; meropenem; antibiotic efflux; imipenem; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; reduced permeability to antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and intercalating dyes; protein(s) and two-component regulatory system modulating antibiotic efflux; acridine dye; penam; Outer Membrane Porin (Opr); efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 334 UPDATE mexX erythromycin; arbekacin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and intercalating dyes; acridine dye; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3806 UPDATE ParR erythromycin; penem; tetracycline antibiotic; meropenem; antibiotic efflux; imipenem; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; reduced permeability to antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and intercalating dyes; protein(s) and two-component regulatory system modulating antibiotic efflux; acridine dye; penam; Outer Membrane Porin (Opr); efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3755 UPDATE qacEdelta1 antibiotic efflux; acridine dye; major facilitator superfamily (MFS) antibiotic efflux pump; disinfecting agents and intercalating dyes; efflux pump complex or subunit conferring antibiotic resistance; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3754 UPDATE qacE efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; disinfecting agents and intercalating dyes; antibiotic efflux; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 600 UPDATE CMY-2 penam; carbapenem; cephalosporin; cefazolin; ceftazidime; cefalotin; cephamycin; antibiotic inactivation; cefixime; amoxicillin; ampicillin; clavulanic acid; CMY beta-lactamase; ceftriaxone; cefoxitin; amoxicillin-clavulanic acid; ertapenem; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with cefazolin UPDATED category_aro_cvterm_id with 35975 UPDATED category_aro_accession with 0000058 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with carbapenem UPDATED category_aro_cvterm_id with 35939 UPDATED category_aro_accession with 0000020 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with clavulanic acid UPDATED category_aro_cvterm_id with 35996 UPDATED category_aro_accession with 0000079 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. UPDATED category_aro_name with amoxicillin UPDATED category_aro_cvterm_id with 35981 UPDATED category_aro_accession with 0000064 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. UPDATED category_aro_name with cefixime UPDATED category_aro_cvterm_id with 36990 UPDATED category_aro_accession with 3000646 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. UPDATED category_aro_name with ceftriaxone UPDATED category_aro_cvterm_id with 35979 UPDATED category_aro_accession with 0000062 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. UPDATED category_aro_name with amoxicillin-clavulanic acid UPDATED category_aro_cvterm_id with 40924 UPDATED category_aro_accession with 3003997 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). UPDATED category_aro_name with ertapenem UPDATED category_aro_cvterm_id with 35987 UPDATED category_aro_accession with 0000070 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis. " 3902 UPDATE CMY-164 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-164 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 26-JUN-2019. UPDATED param_value with 700 " 2207 UPDATE MexV antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; macrolide antibiotic; disinfecting agents and intercalating dyes; acridine dye; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2208 UPDATE MexW antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; macrolide antibiotic; disinfecting agents and intercalating dyes; acridine dye; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 182 UPDATE arlS antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; acridine dye; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3898 UPDATE CMY-156 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-156 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 14-FEB-2018. UPDATED param_value with 700 " 3899 UPDATE CMY-160 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-160 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 29-MAY-2018. UPDATED param_value with 700 " 735 UPDATE TEM-30 penam; antibiotic inactivation; monobactam; penem; cephalosporin; cefalotin; amoxicillin; ampicillin; clavulanic acid; TEM beta-lactamase; amoxicillin-clavulanic acid; ARO_category "UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. " 3892 UPDATE CMY-107 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-107 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. UPDATED param_value with 775 " 3893 UPDATE CMY-158 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-158 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 06-NOV-2018. UPDATED param_value with 775 " 3890 UPDATE CMY-134 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-134 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. UPDATED param_value with 775 " 3891 UPDATE CMY-143 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-143 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 16-NOV-2016. UPDATED param_value with 700 " 3896 UPDATE CMY-147 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-147 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-FEB-2017. UPDATED param_value with 700 " 3897 UPDATE CMY-146 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-146 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-JAN-2017. UPDATED param_value with 700 " 3894 UPDATE CMY-173 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-173 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-SEP-2020. UPDATED param_value with 775 " 2425 UPDATE hmrM antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; multidrug and toxic compound extrusion (MATE) transporter; acridine dye; acriflavine; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3281 UPDATE Acinetobacter baumannii AbuO penam; antibiotic efflux; amikacin; resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; benzalkonium chloride; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; tigecycline; glycylcycline; carbenicillin; tetracycline antibiotic; streptomycin; ceftriaxone; meropenem; ARO_description "UPDATED ARO_description with AbuO is akin to the TolC outer membrane efflux protein. Deletion in A. baumannii results in increased susceptibility to antibiotics including amikacin, carbenicillin, ceftriaxone, meropenem, streptomycin, and tigecycline as well as disinfectants benzyalkonium chloride and chlorhexidine. " 3280 UPDATE Acinetobacter baumannii AmvA antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; macrolide antibiotic; acridine dye; acriflavine; disinfecting agents and intercalating dyes; erythromycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2213 UPDATE opmE kitasamycin; imipenem; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; trimethoprim; macrolide antibiotic; disinfecting agents and intercalating dyes; carbapenem; acridine dye; diaminopyrimidine antibiotic; acriflavine; tetracycline antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2212 UPDATE mexQ kitasamycin; imipenem; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; trimethoprim; macrolide antibiotic; disinfecting agents and intercalating dyes; carbapenem; acridine dye; diaminopyrimidine antibiotic; acriflavine; tetracycline antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2211 UPDATE mexP kitasamycin; imipenem; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; trimethoprim; macrolide antibiotic; disinfecting agents and intercalating dyes; carbapenem; acridine dye; diaminopyrimidine antibiotic; acriflavine; tetracycline antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 995 UPDATE MexG antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; acridine dye; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; tetracycline; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3904 UPDATE CMY-165 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-165 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-AUG-2019. UPDATED param_value with 700 " 3905 UPDATE CMY-166 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-166 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-AUG-2019. UPDATED param_value with 700 " 3906 UPDATE CMY-149 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-149 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-MAY-2017. UPDATED param_value with 700 " 3907 UPDATE CMY-139 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-139 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. UPDATED param_value with 700 " 3900 UPDATE CMY-162 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-162 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 21-JUN-2018. UPDATED param_value with 700 " 154 UPDATE mgrA tetracycline antibiotic; moxifloxacin; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; cephalosporin; ciprofloxacin; moenomycin A1; disinfecting agents and intercalating dyes; protein(s) and two-component regulatory system modulating antibiotic efflux; peptide antibiotic; acridine dye; daptomycin; penam; cefotaxime; sparfloxacin; methicillin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; fluoroquinolone antibiotic; tetracycline; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2732 UPDATE MexVW-OprM antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; macrolide antibiotic; disinfecting agents and intercalating dyes; acridine dye; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3903 UPDATE CMY-161 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-161 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 24-MAY-2018. UPDATED param_value with 700 " 3908 UPDATE CMY-148 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-148 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-MAY-2017. UPDATED param_value with 700 " 3909 UPDATE CMY-163 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-163 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 25-JUN-2018. UPDATED param_value with 700 " 1191 UPDATE mdtM antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; norfloxacin; disinfecting agents and intercalating dyes; acridine dye; lincomycin; puromycin; acriflavine; nucleoside antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; phenicol antibiotic; chloramphenicol; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 45 UPDATE mdtP antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; acridine dye; puromycin; acriflavine; nucleoside antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2223 UPDATE MexZ erythromycin; arbekacin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and intercalating dyes; protein(s) and two-component regulatory system modulating antibiotic efflux; acridine dye; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2035 UPDATE CTX-M-15 penam; antibiotic inactivation; cephalosporin; cefazolin; ceftazidime; cefalotin; ampicillin; ceftriaxone; CTX-M beta-lactamase; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with cefazolin UPDATED category_aro_cvterm_id with 35975 UPDATED category_aro_accession with 0000058 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. " 3915 UPDATE CMY-145 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-145 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-JAN-2017. UPDATED param_value with 700 " 1442 UPDATE mdtN antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; acridine dye; puromycin; acriflavine; nucleoside antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3917 UPDATE CMY-157 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-96 is a beta-lactamase found in Citrobacter sp. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-NOV-2018. UPDATED param_value with 700 " 3916 UPDATE CMY-122 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-122 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-MAY-2016. UPDATED param_value with 700 " 618 UPDATE emeA antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; multidrug and toxic compound extrusion (MATE) transporter; acridine dye; acriflavine; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3914 UPDATE CMY-125 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-125 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-MAY-2016. UPDATED param_value with 700 " 3913 UPDATE CMY-124 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-124 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. UPDATED param_value with 700 " 3912 UPDATE CMY-141 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-141 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-JUN-2018. UPDATED param_value with 700 " 3911 UPDATE CMY-142 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-142 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 05-JUN-2016. UPDATED param_value with 700 " 3910 UPDATE CMY-154 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-154 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 21-JUN-2017. UPDATED param_value with 700 " 3919 UPDATE CMY-155 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-155 is a beta-lactamase found in Klebsiella sp. KF07. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-AUG-2017. UPDATED param_value with 700 " 3918 UPDATE CMY-171 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-171 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 14-APR-2020. UPDATED param_value with 700 " 3786 UPDATE cmlA9 antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_category "UPDATED category_aro_name with phenicol antibiotic UPDATED category_aro_cvterm_id with 36526 UPDATED category_aro_accession with 3000387 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome. UPDATED category_aro_name with chloramphenicol UPDATED category_aro_cvterm_id with 36524 UPDATED category_aro_accession with 3000385 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation. " 1975 UPDATE blt antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; acridine dye; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 355 UPDATE TEM-1 penam; antibiotic inactivation; monobactam; penem; cephalosporin; cefazolin; piperacillin-tazobactam; cefalotin; amoxicillin; ampicillin; clavulanic acid; piperacillin; tazobactam; TEM beta-lactamase; amoxicillin-clavulanic acid; ARO_category "UPDATED category_aro_name with cefazolin UPDATED category_aro_cvterm_id with 35975 UPDATED category_aro_accession with 0000058 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with piperacillin-tazobactam UPDATED category_aro_cvterm_id with 40951 UPDATED category_aro_accession with 3004021 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the penam beta-lactam antibiotic Piperacillin and the beta-lactamase inhibitor Tazobactam. UPDATED category_aro_name with clavulanic acid UPDATED category_aro_cvterm_id with 35996 UPDATED category_aro_accession with 0000079 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. UPDATED category_aro_name with piperacillin UPDATED category_aro_cvterm_id with 35995 UPDATED category_aro_accession with 0000078 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria. UPDATED category_aro_name with tazobactam UPDATED category_aro_cvterm_id with 35994 UPDATED category_aro_accession with 0000077 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Tazobactam is a compound which inhibits the action of bacterial beta-lactamases. UPDATED category_aro_name with amoxicillin-clavulanic acid UPDATED category_aro_cvterm_id with 40924 UPDATED category_aro_accession with 3003997 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). " 352 UPDATE PDC-5 penam; carbapenem; monobactam; cephalosporin; cefazolin; ampicillin; ceftazidime; cefalotin; cephamycin; antibiotic inactivation; amoxicillin; PDC beta-lactamase; clavulanic acid; cefixime; ceftriaxone; cefoxitin; amoxicillin-clavulanic acid; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with cefazolin UPDATED category_aro_cvterm_id with 35975 UPDATED category_aro_accession with 0000058 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with cephamycin UPDATED category_aro_cvterm_id with 35962 UPDATED category_aro_accession with 0000044 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases. UPDATED category_aro_name with clavulanic acid UPDATED category_aro_cvterm_id with 35996 UPDATED category_aro_accession with 0000079 UPDATED category_aro_class_name with Adjuvant UPDATED category_aro_description with Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. UPDATED category_aro_name with amoxicillin UPDATED category_aro_cvterm_id with 35981 UPDATED category_aro_accession with 0000064 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. UPDATED category_aro_name with cefixime UPDATED category_aro_cvterm_id with 36990 UPDATED category_aro_accession with 3000646 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. UPDATED category_aro_name with ceftriaxone UPDATED category_aro_cvterm_id with 35979 UPDATED category_aro_accession with 0000062 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. UPDATED category_aro_name with cefoxitin UPDATED category_aro_cvterm_id with 35927 UPDATED category_aro_accession with 0000008 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. UPDATED category_aro_name with amoxicillin-clavulanic acid UPDATED category_aro_cvterm_id with 40924 UPDATED category_aro_accession with 3003997 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). " 3901 UPDATE CMY-140 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_param "UPDATED ARO_description with CMY-140 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-JUN-2018. UPDATED param_value with 700 " 1368 UPDATE abeM antibiotic efflux; triclosan; efflux pump complex or subunit conferring antibiotic resistance; ofloxacin; norfloxacin; multidrug and toxic compound extrusion (MATE) transporter; acridine dye; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and intercalating dyes; ARO_category "UPDATED category_aro_name with disinfecting agents and intercalating dyes UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Molecules that intercalate DNA or act as disinfectants that also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3922 ADD SHV-205 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3923 ADD SHV-222 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3926 ADD SHV-201 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3927 ADD SHV-212 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3924 ADD SHV-198 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3925 ADD SHV-195 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3928 ADD SHV-204 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3929 ADD SHV-197 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 4026 ADD PDC-461 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4027 ADD PDC-19a PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4024 ADD PDC-19b PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4025 ADD PDC-380 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4022 ADD PDC-352 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4023 ADD PDC-464 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4020 ADD PDC-337 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4021 ADD PDC-212 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4028 ADD PDC-272 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4029 ADD PDC-255 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 3999 ADD TEM-236 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3998 ADD TEM-235 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3997 ADD TEM-234 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3996 ADD TEM-233 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3995 ADD TEM-232 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3994 ADD TEM-231 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3993 ADD TEM-230 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3992 ADD TEM-229 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3991 ADD TEM-228 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3990 ADD TEM-227 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3939 ADD CMY-153 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3938 ADD CMY-89 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3935 ADD CMY-128 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3934 ADD CMY-151 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3937 ADD CMY-127 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3936 ADD CMY-129 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3931 ADD CMY-121 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3930 ADD SHV-216 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3933 ADD CMY-97 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3932 ADD CMY-152 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 4031 ADD PDC-183 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4030 ADD PDC-293 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4033 ADD PDC-306 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4032 ADD PDC-207 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4035 ADD PDC-117 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4034 ADD PDC-376 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4037 ADD PDC-104 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4036 ADD PDC-231 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4039 ADD PDC-292 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4038 ADD PDC-173 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 3948 ADD SHV-208 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3949 ADD SHV-206 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3940 ADD CMY-130 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3941 ADD CMY-144 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3942 ADD CMY-138 antibiotic inactivation; CMY beta-lactamase; cephamycin; N/A N/A 3943 ADD mcr-3.41 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; N/A N/A 3944 ADD OXA-544 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 3945 ADD SHV-194 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3946 ADD SHV-220 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3947 ADD SHV-210 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 4044 ADD PDC-429 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4045 ADD PDC-449 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4046 ADD OXA-540 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4047 ADD OXA-779 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4040 ADD PDC-393 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4041 ADD PDC-119 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4042 ADD PDC-313 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4043 ADD PDC-257 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4048 ADD OXA-838 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4049 ADD OXA-539 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 3959 ADD SHV-1b-b carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3958 ADD SHV-207 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3953 ADD SHV-219 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3952 ADD SHV-211 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3951 ADD SHV-196 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3950 ADD SHV-226 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3957 ADD SHV-214 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3956 ADD SHV-223 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3955 ADD SHV-227 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3954 ADD SHV-199 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 4116 ADD KPC-55 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4117 ADD KPC-56 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4114 ADD KPC-52 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4115 ADD KPC-54 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4112 ADD KPC-50 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4113 ADD KPC-51 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4110 ADD KPC-46 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4111 ADD KPC-49 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4118 ADD KPC-57 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4057 ADD OXA-573 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4056 ADD OXA-570 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4055 ADD OXA-926 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4054 ADD OXA-835 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4053 ADD OXA-541 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4052 ADD OXA-737 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4051 ADD OXA-681 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4050 ADD OXA-543 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4059 ADD OXA-672 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4058 ADD OXA-571 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4101 ADD KPC-36 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4100 ADD KPC-35 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4103 ADD KPC-38 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4102 ADD KPC-37 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4105 ADD KPC-40 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4104 ADD KPC-39 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4107 ADD KPC-42 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4106 ADD KPC-41 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4109 ADD KPC-45 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4108 ADD KPC-43 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4062 ADD OXA-931 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4063 ADD OXA-930 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4060 ADD OXA-671 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4061 ADD OXA-673 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4066 ADD Trimethoprim-resistant dihydrofolate reductase DfrA42 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4067 ADD OXA-496 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4064 ADD OXA-895 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4065 ADD OXA-641 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4068 ADD OXA-915 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4069 ADD oxa-647 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4079 ADD DfrA37 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4078 ADD DfrA34 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4075 ADD OXA-499 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4074 ADD OXA-653 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4077 ADD Trimethoprim-resistant dihydrofolate reductase DfrA43 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4076 ADD OXA-825 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4071 ADD OXA-646 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4070 ADD OXA-648 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4073 ADD OXA-897 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 4072 ADD OXA-649 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 3966 ADD ADC-181 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; N/A N/A 3967 ADD ADC-182 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; N/A N/A 3964 ADD SHV-209 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3965 ADD SHV-215 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3962 ADD SHV-224 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3963 ADD SHV-225 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3960 ADD SHV-218 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3961 ADD SHV-193 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3968 ADD ADC-183 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; N/A N/A 3969 ADD SHV-228 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 4080 ADD DfrA36 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4081 ADD DfrA38 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4082 ADD DfrB9 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4083 ADD DfrA39 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4085 ADD dfr22 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; N/A N/A 4088 ADD KPC-23 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4089 ADD KPC-25 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4008 ADD PDC-284 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4009 ADD PDC-105 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4000 ADD TEM-237 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 4001 ADD TEM-238 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 4002 ADD TEM-240 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 4003 ADD TEM-241 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 4004 ADD TEM-242 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 4005 ADD TEM-243 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 4006 ADD PDC-225 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4007 ADD PDC-438 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 3971 ADD SHV-203 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3970 ADD SHV-200 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3973 ADD SHV-213 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3972 ADD SHV-217 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3975 ADD SHV-202 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3974 ADD SHV-221 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; N/A N/A 3977 ADD TEM-9 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3976 ADD TEM-5 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3979 ADD TEM-32 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3978 ADD TEM-31 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 4093 ADD KPC-29 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4092 ADD KPC-27 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4091 ADD KPC-18 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4090 ADD KPC-26 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4097 ADD KPC-30 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4096 ADD KPC-32 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4095 ADD KPC-31 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4094 ADD KPC-28 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4099 ADD KPC-34 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4098 ADD KPC-33 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; N/A N/A 4019 ADD PDC-285 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4018 ADD PDC-346 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4013 ADD PDC-323 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4012 ADD PDC-324 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4011 ADD PDC-384 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4010 ADD PDC-118 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4017 ADD PDC-201 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4016 ADD PDC-264 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4015 ADD PDC-413 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 4014 ADD PDC-258 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; N/A N/A 3988 ADD TEM-225 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3989 ADD TEM-226 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3985 ADD TEM-210 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3986 ADD TEM-212 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3987 ADD TEM-224 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3980 ADD TEM-35 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3981 ADD TEM-36 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3982 ADD TEM-37 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 3983 ADD TEM-39 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A