{"$update": {"5259": {"$insert": {"CARD_short_name": "PDC-123"}}, "4446": {"$insert": {"CARD_short_name": "CfiA11"}}, "4447": {"$insert": {"CARD_short_name": "CfiA14"}}, "1020": {"$update": {"ARO_description": "OXA-241 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1759": {"$update": {"dna_sequence": {"$update": {"accession": "JX025021.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-241"}}, "4026": {"$update": {"ARO_description": "PDC-461 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-461"}}, "4027": {"$update": {"ARO_description": "PDC-19a is a class C beta-lactamase found in Pseudomonas (multispecies)."}, "$insert": {"CARD_short_name": "PDC-19a"}}, "4024": {"$update": {"ARO_description": "PDC-19b is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-19b"}}, "4025": {"$update": {"ARO_description": "PDC-380 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-380"}}, "4022": {"$update": {"ARO_description": "PDC-352 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-352"}}, "4023": {"$update": {"ARO_description": "PDC-464 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-464"}}, "4020": {"$update": {"ARO_description": "PDC-337 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-337"}}, "4021": {"$update": {"ARO_description": "PDC-212 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-212"}}, "854": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1362": {"$update": {"dna_sequence": {"$update": {"accession": "HQ185697.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-58"}}, "4028": {"$update": {"ARO_description": "PDC-272 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-272"}}, "4029": {"$update": {"ARO_description": "PDC-255 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-255"}}, "5080": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-771"}}, "344": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"989": {"$update": {"dna_sequence": {"$update": {"accession": "LN515534.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-188"}}, "345": {"$update": {"ARO_description": "bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance.", "model_sequences": {"$update": {"sequence": {"$update": {"745": {"$update": {"dna_sequence": {"$update": {"accession": "L20573.1"}}}}}}}}}, "$insert": {"CARD_short_name": "bcrA"}}, "346": {"$update": {"ARO_description": "QnrB23 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"720": {"$update": {"dna_sequence": {"$update": {"accession": "FJ981622.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB23"}}, "347": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1878": {"$update": {"dna_sequence": {"$update": {"accession": "AF197943.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SFH-1"}}, "340": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"904": {"$update": {"dna_sequence": {"$update": {"accession": "JQ733571.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-51"}}, "341": {"$update": {"ARO_description": "IMP-1 is a beta-lactamase found in Serratia marcescens.", "model_sequences": {"$update": {"sequence": {"$update": {"1594": {"$update": {"dna_sequence": {"$update": {"accession": "AJ223604.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-1"}}, "342": {"$update": {"ARO_description": "smeS is the protein kinase sensor component of a two component signal transduction system that includes smeR.", "model_sequences": {"$update": {"sequence": {"$update": {"4492": {"$update": {"dna_sequence": {"$update": {"accession": "AF173226.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "smeS"}}, "343": {"$update": {"ARO_description": "OXA-31 is a beta-lactamase found in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1211": {"$update": {"dna_sequence": {"$update": {"accession": "AF294653.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-31"}}, "3997": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-234"}}, "3996": {"$update": {"ARO_description": "TEM-233 is a beta-lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-233"}}, "3995": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-232"}}, "3994": {"$update": {"ARO_description": "TEM-231 is a beta-lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-231"}}, "348": {"$update": {"ARO_description": "OXY-3-1 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1848": {"$update": {"dna_sequence": {"$update": {"accession": "AF491278.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-3-1"}}, "349": {"$update": {"ARO_description": "VanL is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.", "model_sequences": {"$update": {"sequence": {"$update": {"612": {"$update": {"dna_sequence": {"$update": {"accession": "EU250284.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanL"}}, "3991": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-228"}}, "3990": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-227"}}, "4686": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-59"}}, "4687": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-60"}}, "966": {"$update": {"ARO_description": "Also known as vanSC, is a vanS variant found in the vanC gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"565": {"$update": {"dna_sequence": {"$update": {"accession": "AF162694.1"}}}}}}}}, "model_name": "vanS gene in vanC cluster", "ARO_name": "vanS gene in vanC cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanC_cl"}}, "967": {"$update": {"ARO_description": "AAC(6')-Isa is a plasmid-encoded aminoglycoside acetyltransferase in Streptomyces albulus.", "model_sequences": {"$update": {"sequence": {"$update": {"705": {"$update": {"dna_sequence": {"$update": {"accession": "AB116646.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Isa"}}, "5373": {"$insert": {"CARD_short_name": "PDC-235"}}, "1653": {"$update": {"ARO_description": "AAC(6')-Ip is an aminoglycoside acetyltransferase encoded by plasmids and integrons in C. freundii, E. coli, E. faecium and Klebsiella aerogenes."}, "$insert": {"CARD_short_name": "AAC(6')-Ip"}}, "4934": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-608"}}, "4683": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-53"}}, "4732": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-73"}}, "4733": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-74"}}, "4730": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-71"}}, "4731": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-72"}}, "4736": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-77"}}, "4737": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-78"}}, "4734": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-75"}}, "4735": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-76"}}, "2317": {"$update": {"ARO_description": "mgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae.", "ARO_category": {"$update": {"40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}}, "$insert": {"CARD_short_name": "mgrB"}}, "2314": {"$insert": {"CARD_short_name": "Abau_gyrA_FLO"}}, "2315": {"$update": {"model_name": "Acinetobacter baumannii parC conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Abau_parC_FLO"}}, "3572": {"$insert": {"CARD_short_name": "CIA-3"}}, "2310": {"$insert": {"CARD_short_name": "Scin_EFTu_ELF"}}, "4831": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-493"}}, "298": {"$update": {"ARO_description": "Also known as vanYG, is a vanY variant found in the vanG gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"416": {"$update": {"dna_sequence": {"$update": {"accession": "DQ212986.1"}}}}}}}}, "model_name": "vanY gene in vanG cluster", "ARO_name": "vanY gene in vanG cluster"}, "$insert": {"CARD_short_name": "vanY_in_vanG_cl"}}, "299": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3286": {"$update": {"dna_sequence": {"$update": {"accession": "X80277.1"}}}}}}}}, "model_name": "CepS"}, "$insert": {"CARD_short_name": "CepS"}}, "296": {"$update": {"ARO_description": "VIM-23 is a beta-lactamase found in Enterobacter cloacae.", "model_sequences": {"$update": {"sequence": {"$update": {"1729": {"$update": {"dna_sequence": {"$update": {"accession": "GQ242167.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-23"}}, "297": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1778": {"$update": {"dna_sequence": {"$update": {"accession": "KC603538.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-98"}}, "294": {"$update": {"ARO_description": "cfxA4 beta-lactamase is a class A beta-lactamase found in Bacteroides fragilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1592": {"$update": {"dna_sequence": {"$update": {"accession": "AY769933.1"}}}}}}}}, "ARO_category": {"$update": {"39434": {"$update": {"category_aro_description": "CfxA beta-lactamases are class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "CfxA4"}}, "295": {"$update": {"ARO_description": "OXA-145 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1451": {"$update": {"dna_sequence": {"$update": {"accession": "FJ790516.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-145"}}, "292": {"$update": {"model_sequences": {"$update": {"sequence": {"8244": {"dna_sequence": {"partial": "0", "sequence": "ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAACAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTAAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTTTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATTTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "fmax": "861", "accession": "Y14574.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Capnocytophaga ochracea", "NCBI_taxonomy_id": "1018", "NCBI_taxonomy_cvterm_id": "36958"}, "protein_sequence": {"accession": "CAA74912.2", "sequence": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-17"}}, "293": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-180"}}, "290": {"$update": {"ARO_description": "vatD is a transposon-mediated acetyltransferase found in Enterococcus faecium.", "model_sequences": {"$update": {"sequence": {"$update": {"462": {"$update": {"dna_sequence": {"$update": {"accession": "AF368302.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vatD"}}, "291": {"$update": {"ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-Ia"}}, "3773": {"$insert": {"CARD_short_name": "CTX-M-161"}}, "3772": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FLC-1"}}, "3771": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-9"}}, "3770": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-8"}}, "3777": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamase, no other information available."}, "$insert": {"CARD_short_name": "CTX-M-165"}}, "3776": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamase, no other information available."}, "$insert": {"CARD_short_name": "CTX-M-164"}}, "3775": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamase, no other information available."}, "$insert": {"CARD_short_name": "CTX-M-163"}}, "3774": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamase, no other information available."}, "$insert": {"CARD_short_name": "CTX-M-162"}}, "4835": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-500"}}, "3779": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Yrc-1"}}, "3778": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamase, no other information available."}, "$insert": {"CARD_short_name": "CTX-M-166"}}, "4834": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-498"}}, "270": {"$update": {"ARO_description": "LEN-20 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8276": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGGTCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGTGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM850910.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12348.2", "sequence": "MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTVGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPVSMAERNQHIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-20"}}, "271": {"$update": {"ARO_description": "CMY-4 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1179": {"$update": {"dna_sequence": {"$update": {"accession": "Y15130.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-4"}}, "272": {"$update": {"ARO_description": "QnrB36 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"591": {"$update": {"dna_sequence": {"$update": {"accession": "JN173058.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB36"}}, "273": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1728": {"$update": {"dna_sequence": {"$update": {"accession": "FJ825622.1"}}}}}}}}, "ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-7"}}, "274": {"$update": {"ARO_description": "OXA-174 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"2002": {"$update": {"dna_sequence": {"$update": {"accession": "HM113560.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-174"}}, "275": {"$update": {"ARO_description": "OKP-B-2 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1366": {"$update": {"dna_sequence": {"$update": {"accession": "AM051151.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-2"}}, "276": {"$update": {"ARO_description": "TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin.", "model_sequences": {"$update": {"sequence": {"$update": {"2090": {"$update": {"dna_sequence": {"$update": {"accession": "AL513383.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tetR"}}, "277": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1888": {"$update": {"dna_sequence": {"$update": {"accession": "AB049569.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-91"}}, "278": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1892": {"$update": {"dna_sequence": {"$update": {"accession": "Y10415.1"}}}}}}}}}, "$insert": {"CARD_short_name": "imiS"}}, "279": {"$update": {"model_sequences": {"$update": {"sequence": {"8376": {"dna_sequence": {"partial": "1", "sequence": "GGTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAGAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCA", "fmax": "864", "accession": "JF274244.1", "fmin": "1", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella sp. SH219", "NCBI_taxonomy_id": "1074433", "NCBI_taxonomy_cvterm_id": "39656"}, "protein_sequence": {"accession": "AEM44650.1", "sequence": "VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDRTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-107"}}, "4836": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-501"}}, "4659": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-46"}}, "4658": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-45"}}, "2814": {"$insert": {"CARD_short_name": "Mint_23S_AZM"}}, "4784": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-21"}}, "1023": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1985": {"$update": {"dna_sequence": {"$update": {"accession": "AY553332.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-14"}}, "1780": {"$update": {"ARO_description": "OXA-146 is a beta-lactamase found in Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"1524": {"$update": {"dna_sequence": {"$update": {"accession": "FJ194494.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-146"}}, "2146": {"$update": {"ARO_description": "Point mutations in the 5' domain of helix 18, in the rrnB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"3237": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin"}, "$insert": {"CARD_short_name": "Ecol_16S_STR"}}, "941": {"$update": {"ARO_description": "GES-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1593": {"$update": {"dna_sequence": {"$update": {"accession": "AF156486.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-1"}}, "2268": {"$insert": {"CARD_short_name": "eatAv"}}, "4431": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-47"}}, "2262": {"$insert": {"CARD_short_name": "mefC"}}, "2263": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3517": {"$update": {"dna_sequence": {"$update": {"accession": "KP399637.1"}}, "protein_sequence": {"$update": {"accession": "AKA86814.1"}}}}}}}}}, "$insert": {"CARD_short_name": "optrA"}}, "2260": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3514": {"$update": {"dna_sequence": {"$update": {"accession": "AF170730.1"}}, "protein_sequence": {"$update": {"accession": "AAF63432.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vatF"}}, "2261": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3515": {"$update": {"dna_sequence": {"$update": {"accession": "KF287643.1"}}, "protein_sequence": {"$update": {"accession": "AGT57825.1"}}}}}}}}}, "$insert": {"CARD_short_name": "lnuE"}}, "2267": {"$insert": {"CARD_short_name": "Ecol_nfsA_NIT"}}, "2264": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3518": {"$update": {"dna_sequence": {"$update": {"accession": "L06249.1"}}, "protein_sequence": {"$update": {"accession": "AAA26793.1"}}}}}}}}}, "$insert": {"CARD_short_name": "oleC"}}, "2265": {"$update": {"ARO_description": "salA is an ABC-F subfamily protein gene isolated from the chromosome of Mammaliicoccus sciuri conferring resistance to lincosamides and streptogramins.", "model_sequences": {"$update": {"sequence": {"$update": {"3519": {"$update": {"dna_sequence": {"$update": {"accession": "KC693025.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Mammaliicoccus sciuri", "NCBI_taxonomy_id": "1296", "NCBI_taxonomy_cvterm_id": "36794"}}, "protein_sequence": {"$update": {"accession": "AGN74946.1"}}}}}}}}, "ARO_category": {"$delete": ["37716"], "$insert": {"37013": {"category_aro_name": "virginiamycin M1", "category_aro_cvterm_id": "37013", "category_aro_accession": "3000669", "category_aro_class_name": "Antibiotic", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}, "37713": {"category_aro_name": "retapamulin", "category_aro_cvterm_id": "37713", "category_aro_accession": "3001314", "category_aro_class_name": "Antibiotic", "category_aro_description": "Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections."}, "37015": {"category_aro_name": "tiamulin", "category_aro_cvterm_id": "37015", "category_aro_accession": "3000671", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation."}, "35983": {"category_aro_name": "clindamycin", "category_aro_cvterm_id": "35983", "category_aro_accession": "0000066", "category_aro_class_name": "Antibiotic", "category_aro_description": "Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria."}}}}, "$insert": {"CARD_short_name": "salA"}}, "1781": {"$update": {"ARO_description": "AAC(2')-Ia is a chromosomal-encoded aminoglycoside acetyltransferase in P. stuartii.", "model_sequences": {"$update": {"sequence": {"8144": {"dna_sequence": {"partial": "0", "sequence": "ATGGGCATAGAATACCGCAGTCTGCATACCAGCCAATTGACACTGAGTGAAAAAGAAGCGCTTTACGATTTATTAATTGAAGGTTTTGAAGGCGATTTTTCGCATGACGATTTCGCGCACACTTTAGGTGGAATGCACGTCATGGCTTTTGATCAACAAAAATTGGTTGGTCATGTTGCAATTATTCAACGCCATATGGCCCTAGATAATACGCCTATCTCTGTAGGGTATGTTGAAGCGATGGTAGTTGAACAAAGTTATCGTCGCCAAGGTATTGGGCGGCAATTGATGCTGCAAACCAATAAAATTATAGCTTCGTGTTATCAATTAGGGCTGCTGTCGGCTTCAGATGATGGACAAAAATTGTATCATTCGGTTGGATGGCAAATCTGGAAAGGTAAGTTGTTTGAATTGAAACAAGGGAGCTATATCCGTTCTATTGAAGAAGAAGGCGGAGTCATGGGCTGGAAAGCGGATGGTGAGGTTGATTTTACCGCTTCGCTTTACTGTGATTTTCGTGGCGGTGATCAGTGGTAA", "fmax": "800", "accession": "L06156.2", "fmin": "263", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Providencia stuartii", "NCBI_taxonomy_id": "588", "NCBI_taxonomy_cvterm_id": "36946"}, "protein_sequence": {"accession": "AAA03550.1", "sequence": "MGIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHVMAFDQQKLVGHVAIIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLMLQTNKIIASCYQLGLLSASDDGQKLYHSVGWQIWKGKLFELKQGSYIRSIEEEGGVMGWKADGEVDFTASLYCDFRGGDQW"}}}}}}, "$insert": {"CARD_short_name": "AAC(2')-Ia"}}, "2445": {"$update": {"model_name": "Erm(44)v"}, "$insert": {"CARD_short_name": "Erm(44)v"}}, "108": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1940": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666071.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PDC-8"}}, "109": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"384": {"$update": {"dna_sequence": {"$update": {"accession": "X51891.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmE"}}, "102": {"$insert": {"CARD_short_name": "TLA-2"}}, "103": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1470": {"$update": {"dna_sequence": {"$update": {"accession": "AJ920369.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-12"}}, "100": {"$update": {"ARO_description": "Specific mutations that occurs on Mycobacterium tuberculosis ethA causing it to be ethionamide resistant.", "ARO_category": {"$update": {"40067": {"$update": {"category_aro_description": "ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis."}}, "40050": {"$update": {"category_aro_description": "Mutations that occurs on the ethA genes resulting in the inability to catalyzes the oxidation of ethionamide (ETH) to the corresponding sulfoxide (the active drug)."}}}}}, "$insert": {"CARD_short_name": "Mtub_ethA_ETO"}}, "101": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1397": {"$update": {"dna_sequence": {"$update": {"accession": "AY628175.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-109"}}, "106": {"$update": {"ARO_description": "catB9 is a chromosome-encoded variant of the cat gene found in Vibrio cholerae.", "model_sequences": {"$update": {"sequence": {"$update": {"386": {"$update": {"dna_sequence": {"$update": {"accession": "AF462019.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catB9"}}, "107": {"$update": {"model_sequences": {"$update": {"sequence": {"8238": {"dna_sequence": {"partial": "0", "sequence": "ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTAAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCTGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCATTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGACGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "fmax": "861", "accession": "U95363.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAC32889.2", "sequence": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-43"}}, "104": {"$update": {"ARO_description": "OXA-61 is a beta-lactamase found in Campylobacter jejuni.", "model_sequences": {"$update": {"sequence": {"$update": {"1464": {"$update": {"dna_sequence": {"$update": {"accession": "AY587956.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-61"}}, "105": {"$update": {"ARO_description": "CARB-4 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1585": {"$update": {"dna_sequence": {"$update": {"accession": "U14749.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-4"}}, "2046": {"$insert": {"CARD_short_name": "tet(33)"}}, "2047": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1930": {"$update": {"dna_sequence": {"$update": {"accession": "KF203096.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-322"}}, "2044": {"$update": {"ARO_description": "QnrB31 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8167": {"dna_sequence": {"partial": "0", "sequence": "ATGACGCCATTACTGTATAAGAAAACAGGTACAAATATGGCTCTGGCGCTCGTGGGCGAAAAAATTGACAGAAACCGTTTCACCGGTGAGAAAATTGAAAATAGTACATTTTTTTTATGTGATTTTTCAGGAGCCGACCTGAGCGGCACTGAGTTTATCGGCTGTCAATTCTATGATCGTGAAAGCCAGAAAGGCTGCAATTTTAGTCGTGCGATGTTAAAGGATGCCATTTTTAAAAGCTGCGATTTATCCATGGCGGATTTTCGCAATGCAAGCGCCCTGGGTATTGAGATTTCTCATTGTAGGGCTCAGGGTGCAGATTTTCGCGGCGCAAGCTTTATGAACATGATTACCACGCGCACTTGGTTCTGCAGCGCGTATATCACGAATACGAATCTGTCTTATGCCAATTTTTCGAAAGTCGTGTTGGAGAAGTGTGAGTTATGGGAAAACCGTTGGATGGGTGCCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCAACTTTCGACTGGCGAGCAGCAAACTTTACACATTGCGATCTCACAAATTCGGAGTTGGGTGACTTAGATATTCGTCGGGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCTTCGTTGCTCATGGAGCGACTTGGCATCGCGATAATTGGTTGA", "fmax": "681", "accession": "HQ418999.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "ADQ43424.1", "sequence": "MTPLLYKKTGTNMALALVGEKIDRNRFTGEKIENSTFFLCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEISHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGAQVLGATFSGSDLSGGEFSTFDWRAANFTHCDLTNSELGDLDIRRVDLQGVKLDNYQASLLMERLGIAIIG"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB31"}}, "2045": {"$update": {"ARO_description": "OXY-2-3 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"8260": {"dna_sequence": {"partial": "0", "sequence": "ATGATAAAAAGTTCGTGGCGTAAAATTGCAATGCTAGCCGCCGTTCCGCTGCTGCTGGCGAGCGGCGCACTGTGGGCCAGTACCGATGCTATCCATCAGAAGCTGACAGATCTCGAGAAGCGTTCAGGCGGCAGGTTGGGCGTGGCGCTAATCAACACGGCAGATAATTCTCAAATCTTATATCGCGGCGACGAGCGTTTTGCCATGTGCAGCACCAGTAAAGTGATGGCCGCCGCCGCGGTATTAAAACAGAGCGAAAGCAATAAAGAGGTGGTAAATAAAAGGCTGGAGATTAACGCAGCCGATTTGGTGGTCTGGAGTCCGATTACCGAAAAACATCTCCAGAGCGGAATGACGCTGGCTGAGCTAAGCGCGGCGACGCTGCAATATAGCGACAATACGGCGATGAATCTGATCATCGGCTACCTTGGCGGGCCGGAAAAAGTCACCGCCTTCGCCCGCAGTATCGGCGATGCCACCTTTCGTCTCGATCGTACGGAGCCCACGCTGAATACCGCCATCCCGGGCGATGAGCGTGATACCAGCACGCCGCTGGCGATGGCTGAAAGCCTACGCAAGCTGACGCTTGGCGATGCGCTGGGCGAACAGCAACGCGCCCAGTTAGTCACCTGGCTGAAAGGCAATACCACCGGCGGGCAAAGCATTCGCGCGGGCCTGCCTGAAAGCTGGGTGGTCGGCGATAAAACCGGCGGCGGAGATTACGGCACCACCAATGATATTGCGGTTATCTGGCCGGAAGATCACGCTCCGCTGGTATTAGTCACCTACTTTACCCAGCCGCAGCAGGATGCGAAAAACCGCAAAGAGGTGTTAGCCGCAGCGGCAAAAATCGTGACCGAAGGGCTTTAA", "fmax": "1031", "accession": "AY077488.2", "fmin": "161", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella oxytoca", "NCBI_taxonomy_id": "571", "NCBI_taxonomy_cvterm_id": "36788"}, "protein_sequence": {"accession": "AAL78281.2", "sequence": "MIKSSWRKIAMLAAVPLLLASGALWASTDAIHQKLTDLEKRSGGRLGVALINTADNSQILYRGDERFAMCSTSKVMAAAAVLKQSESNKEVVNKRLEINAADLVVWSPITEKHLQSGMTLAELSAATLQYSDNTAMNLIIGYLGGPEKVTAFARSIGDATFRLDRTEPTLNTAIPGDERDTSTPLAMAESLRKLTLGDALGEQQRAQLVTWLKGNTTGGQSIRAGLPESWVVGDKTGGGDYGTTNDIAVIWPEDHAPLVLVTYFTQPQQDAKNRKEVLAAAAKIVTEGL"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-3"}}, "2042": {"$update": {"ARO_description": "IND-8 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1340": {"$update": {"dna_sequence": {"$update": {"accession": "GU186044.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-8"}}, "2043": {"$update": {"ARO_description": "aadA8 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in V. cholerae, K. pneumoniae and Bacillus endophyticus.", "model_sequences": {"$update": {"sequence": {"$update": {"558": {"$update": {"dna_sequence": {"$update": {"accession": "AY139603.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA8"}}, "2040": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1079": {"$update": {"dna_sequence": {"$update": {"accession": "AF047171.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-60"}}, "2041": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1055": {"$update": {"dna_sequence": {"$update": {"accession": "KM588352.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-424"}}, "4819": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114t"}}, "4818": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114s"}}, "2048": {"$update": {"ARO_description": "OXA-57 is a beta-lactamase found in Burkholderia pseudomallei.", "model_sequences": {"$update": {"sequence": {"$update": {"1137": {"$update": {"dna_sequence": {"$update": {"accession": "AJ631966.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-57"}}, "2049": {"$update": {"ARO_description": "QnrB72 is a plasmid-mediated quinolone resistance protein found in Citrobacter sp. TR21_24.", "model_sequences": {"$update": {"sequence": {"$update": {"469": {"$update": {"dna_sequence": {"$update": {"accession": "KC741443.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB72"}}, "4219": {"$insert": {"CARD_short_name": "ADC-149"}}, "2811": {"$insert": {"CARD_short_name": "Mavi_23S_CLR"}}, "3597": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-11"}}, "4279": {"$insert": {"CARD_short_name": "ADC-214"}}, "4843": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-508"}}, "2032": {"$update": {"ARO_description": "CTX-M-62 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8210": {"dna_sequence": {"partial": "0", "sequence": "ATGGTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGAAGACTGGGGGTGGCATTGATTAACACAGCGGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTCGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTGGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGTCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCAGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGACTATGGCACCACCAACGATATCGCGGTGATTTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA", "fmax": "3001", "accession": "EF219134.3", "fmin": "2125", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "ABP04245.1", "sequence": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTESTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-62"}}, "3519": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-450"}}, "3518": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-449"}}, "5298": {"$insert": {"CARD_short_name": "PDC-16"}}, "3513": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-443"}}, "3512": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-442"}}, "3511": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-441"}}, "3510": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-440"}}, "3517": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-448"}}, "3516": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-447"}}, "3515": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-446"}}, "3514": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-444"}}, "2688": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ArmR"}}, "2689": {"$update": {"ARO_description": "Point mutations in the 23S rRNA subunit of the large ribosomal bacterial subunit in Staphylococcus aureus, which confer resistance to linezolid by disrupting antibiotic target binding."}, "$insert": {"CARD_short_name": "Saur_23S_LZD"}}, "2685": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Paer_CpxR"}}, "2686": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Paer_CpxR_MULT"}}, "2680": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Paer_tMexR_MULT"}}, "2681": {"$update": {"ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "model_name": "Escherichia coli fabG mutations conferring resistance to triclosan"}, "$insert": {"CARD_short_name": "Ecol_fabG_TRC"}}, "2682": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Paer_NalC_ATM"}}, "2683": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics"}, "$insert": {"CARD_short_name": "Paer_NalD_MULT"}}, "5407": {"$insert": {"CARD_short_name": "PDC-273"}}, "3999": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-236"}}, "1249": {"$update": {"ARO_description": "FOX-5 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1276": {"$update": {"dna_sequence": {"$update": {"accession": "AY007369.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-5"}}, "5406": {"$insert": {"CARD_short_name": "PDC-271"}}, "3998": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-235"}}, "1434": {"$update": {"ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Erm(35)"}}, "99": {"$update": {"ARO_description": "QnrB38 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"8281": {"dna_sequence": {"partial": "0", "sequence": "ATGGCTCTGGCATTAATTGGCGAAAAAATTGACAGAAACCGCTTCACCGGTGAAAAAGTTGAAAATAGCACTTTTTTTAACTGTGATTTTTCGGGTGCCGACCTTAGCGGTACTGAATTTATCGGCTGTCAGTTCTATGATCGAGAAAGCCAGAAAGGGTGCAATTTCAGTCGCGCAATACTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAACGTCAGTGCGTTGGGCATAGAAATTCGCCACTGCCGCGCACAGGGTGCAGATTTTCGCGGCGCAAGTTTCATGAATATGATCACCACGCGCACCTGGTTTTGCAGCGCATATATCACTAATACCAATCTAAGCTACGCCAACTTTTCGAAGGCCGTGCTTGAAAAGTGCGAATTGTGGGAAAATCGCTGGATGGGAACTCAGGTACTGGGTGCGACGTTGAGTGGTTCCGATCTCTCCGGTGGCGAGTTTTCGTCGTTCGACTGGCGGACGGCAAATTTCACGCACTGTGATTTGACCAATTCAGAACTGGGTGATTTAGATATTCGGGGCGTCGATTTACAAGGTGTCAAATTGGACAGCTATCAGGCCGCATTGCTCATGGAACGTCTTGGCATCGCTGTCATTGGCTAA", "fmax": "2951", "accession": "JN173060.2", "fmin": "2306", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Citrobacter freundii", "NCBI_taxonomy_id": "546", "NCBI_taxonomy_cvterm_id": "36915"}, "protein_sequence": {"accession": "AEL00461.1", "sequence": "MALALIGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAILKDAIFKSCDLSMADFRNVSALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKAVLEKCELWENRWMGTQVLGATLSGSDLSGGEFSSFDWRTANFTHCDLTNSELGDLDIRGVDLQGVKLDSYQAALLMERLGIAVIG"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB38"}}, "98": {"$update": {"model_sequences": {"$update": {"sequence": {"8245": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "fmax": "2185", "accession": "HM569226.2", "fmin": "1039", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Citrobacter freundii", "NCBI_taxonomy_id": "546", "NCBI_taxonomy_cvterm_id": "36915"}, "protein_sequence": {"accession": "ADP02979.1", "sequence": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ"}}}}}}, "$insert": {"CARD_short_name": "CMY-48"}}, "1435": {"$update": {"ARO_description": "cmlA6 is a plasmid-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"728": {"$update": {"dna_sequence": {"$update": {"accession": "AF294653.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cmlA6"}}, "91": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "gadX"}}, "90": {"$update": {"ARO_description": "Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to rifampicin."}, "$insert": {"CARD_short_name": "Saur_rpoB_RIF"}}, "93": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1941": {"$update": {"dna_sequence": {"$update": {"accession": "FJ194944.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-105"}}, "92": {"$update": {"ARO_description": "CTX-M-42 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1742": {"$update": {"dna_sequence": {"$update": {"accession": "DQ061159.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-42"}}, "95": {"$update": {"ARO_description": "CMY-56 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1196": {"$update": {"dna_sequence": {"$update": {"accession": "HQ322613.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-56"}}, "94": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1897": {"$update": {"dna_sequence": {"$update": {"accession": "JQ733576.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-79"}}, "97": {"$update": {"ARO_description": "Also known as vanXYC, is a vanXY variant found in the vanC gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"39": {"$update": {"dna_sequence": {"$update": {"accession": "AF162694.1"}}}}}}}}, "model_name": "vanXY gene in vanC cluster", "ARO_name": "vanXY gene in vanC cluster"}, "$insert": {"CARD_short_name": "vanXY_in_vanC"}}, "96": {"$update": {"ARO_description": "OXA-426 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem resistant.", "model_sequences": {"$update": {"sequence": {"$update": {"1216": {"$update": {"dna_sequence": {"$update": {"accession": "KM588354.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-426"}}, "1623": {"$update": {"ARO_description": "GIM-2 is a metallo-beta-lactamase present on an integron found in clinical isolates of Enterobacter cloacae in Germany.", "model_sequences": {"$update": {"sequence": {"$update": {"2106": {"$update": {"dna_sequence": {"$update": {"accession": "KM659858.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GIM-2"}}, "1622": {"$update": {"ARO_description": "Also known as vanWG, is a vanW variant found in the vanG gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"535": {"$update": {"dna_sequence": {"$update": {"accession": "DQ212986.1"}}}}}}}}, "model_name": "vanW gene in vanG cluster", "ARO_name": "vanW gene in vanG cluster"}, "$insert": {"CARD_short_name": "vanW_in_vanG_cl"}}, "1993": {"$update": {"ARO_description": "QnrB74 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"556": {"$update": {"dna_sequence": {"$update": {"accession": "KJ415247.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB74"}}, "1620": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1741": {"$update": {"dna_sequence": {"$update": {"accession": "KM211509.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-156"}}, "1627": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"869": {"$update": {"dna_sequence": {"$update": {"accession": "FN813245.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-95"}}, "1626": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"562": {"$update": {"dna_sequence": {"$update": {"accession": "FR772051.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vgaE"}}, "1625": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1126": {"$update": {"dna_sequence": {"$update": {"accession": "HM570035.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-179"}}, "1624": {"$update": {"ARO_description": "lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC."}, "$insert": {"CARD_short_name": "lmrD"}}, "1999": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2127": {"$update": {"dna_sequence": {"$update": {"accession": "KP050492.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-215"}}, "1998": {"$update": {"ARO_description": "CTX-M-83 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"1170": {"$update": {"dna_sequence": {"$update": {"accession": "FJ214366.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-83"}}, "1629": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1493": {"$update": {"dna_sequence": {"$update": {"accession": "HQ877606.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-197"}}, "1628": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1389": {"$update": {"dna_sequence": {"$update": {"accession": "JX121121.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-154"}}, "3992": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6356": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-229"}}, "3398": {"$update": {"ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA10"}}, "3535": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-473"}}, "4376": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6751": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-15"}}, "3534": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-472"}}, "2860": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-81"}}, "2861": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-82"}}, "2862": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-83"}}, "2863": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-84"}}, "2864": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-85"}}, "2865": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-86"}}, "2866": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-87"}}, "2867": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-88"}}, "2868": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-89"}}, "2869": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-90"}}, "557": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1717": {"$update": {"dna_sequence": {"$update": {"accession": "S82452.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-9"}}, "556": {"$update": {"ARO_description": "Also known as vanYB, is a vanY variant found in the vanB gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3457": {"$update": {"dna_sequence": {"$update": {"accession": "U35369.1"}}}}}}}}, "model_name": "vanY gene in vanB cluster", "ARO_name": "vanY gene in vanB cluster"}, "$insert": {"CARD_short_name": "vanY_in_vanB_cl"}}, "551": {"$update": {"ARO_description": "CTX-M-117 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"906": {"$update": {"dna_sequence": {"$update": {"accession": "JN227085.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-117"}}, "550": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1267": {"$update": {"dna_sequence": {"$update": {"accession": "JQ711184.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-71"}}, "553": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1500": {"$update": {"dna_sequence": {"$update": {"accession": "JX982634.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-35"}}, "552": {"$update": {"ARO_description": "QnrB28 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"191": {"$update": {"dna_sequence": {"$update": {"accession": "HM439643.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB28"}}, "5054": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-745"}}, "2744": {"$update": {"ARO_description": "MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB.", "model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_id": "39962", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$delete": ["35954"], "$insert": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}, "36590": {"category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_cvterm_id": "36590", "category_aro_accession": "3000451", "category_aro_class_name": "Efflux Regulator", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux."}}}, "ARO_accession": "3003378"}, "$insert": {"CARD_short_name": "Ecol_MarR_MULT"}}, "5409": {"$insert": {"CARD_short_name": "PDC-275"}}, "5055": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-746"}}, "1502": {"$update": {"ARO_description": "OXA-209 is a beta-lactamase found in Riemerella anatipestifer.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-209"}}, "5408": {"$insert": {"CARD_short_name": "PDC-274"}}, "5678": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-15"}}, "4848": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-513"}}, "1199": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1233": {"$update": {"dna_sequence": {"$update": {"accession": "JX870080.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-168"}}, "1198": {"$update": {"model_name": "mef(B)"}, "$insert": {"CARD_short_name": "mef(B)"}}, "3348": {"$insert": {"CARD_short_name": "cfr(B)"}}, "3349": {"$update": {"ARO_description": "Tetracycline-resistant determinant encoded on the plasmid pKQ10 in Enterococcus faecium."}, "$insert": {"CARD_short_name": "tetU"}}, "1191": {"$update": {"ARO_description": "Multidrug resistance protein MdtM.", "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mdtM"}}, "1190": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1378": {"$update": {"dna_sequence": {"$update": {"accession": "KF297583.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-354"}}, "1193": {"$update": {"ARO_description": "ErmH is a plasmid-mediated methyltransferase found in Streptomyces thermotolerans.", "model_sequences": {"$update": {"sequence": {"$update": {"63": {"$update": {"dna_sequence": {"$update": {"accession": "M16503.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ErmH"}}, "1192": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-1"}}, "1195": {"$update": {"model_sequences": {"$update": {"sequence": {"8263": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTTTATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGAGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTAGCAAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATCGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AJ863560.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAI10727.2", "sequence": "MRFIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-55"}}, "1194": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5866": {"$update": {"dna_sequence": {"$update": {"accession": "AF043100.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-16"}}, "1197": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2087": {"$update": {"dna_sequence": {"$update": {"accession": "AE000516.1"}}}}}}}}, "ARO_category": {"$update": {"40003": {"$update": {"category_aro_description": "Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer antibiotic resistance."}}}}}, "$insert": {"CARD_short_name": "Mtub_rpsL_STR"}}, "1196": {"$update": {"ARO_description": "OXA-71 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1057": {"$update": {"dna_sequence": {"$update": {"accession": "AY750913.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-71"}}, "1759": {"$update": {"ARO_description": "VanF is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance in Paenibacillus popilliae.", "model_sequences": {"$update": {"sequence": {"$update": {"258": {"$update": {"dna_sequence": {"$update": {"accession": "AF155139.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanF"}}, "1758": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"974": {"$update": {"dna_sequence": {"$update": {"accession": "KF203100.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-326"}}, "1757": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"411": {"$update": {"dna_sequence": {"$update": {"accession": "AP009048.1"}}}}}}}}}, "$insert": {"CARD_short_name": "emrA"}}, "1756": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1549": {"$update": {"dna_sequence": {"$update": {"accession": "KF992025.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-93"}}, "1755": {"$update": {"ARO_description": "CTX-M-23 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1411": {"$update": {"dna_sequence": {"$update": {"accession": "AF488377.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-23"}}, "1754": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"675": {"$update": {"dna_sequence": {"$update": {"accession": "KF478993.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanO"}}, "1753": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"829": {"$update": {"dna_sequence": {"$update": {"accession": "JX121115.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-148"}}, "1752": {"$update": {"model_name": "MdtK"}, "$insert": {"CARD_short_name": "MdtK"}}, "1751": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5165": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Mammaliicoccus sciuri"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Erm(33)"}}, "1750": {"$update": {"ARO_description": "OXA-254 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1530": {"$update": {"dna_sequence": {"$update": {"accession": "AB781687.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-254"}}, "1177": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1786": {"$update": {"dna_sequence": {"$update": {"accession": "HQ641421.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-12"}}, "1176": {"$update": {"ARO_category": {"$update": {"40000": {"$update": {"category_aro_description": "Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. It is a catalase-peroxidases that catalyzes the activation of isoniazid. Mutations that arises within this protein cause changes that results in the inability for katG to activate antibiotics, conferring resistance."}}}}, "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"12300": "P365R"}}, "clinical": {"$insert": {"12300": "P365R"}}}}}}}, "$insert": {"CARD_short_name": "Mtub_katG_INH"}}, "1175": {"$insert": {"CARD_short_name": "Efac_cls_DAP"}}, "1174": {"$update": {"ARO_description": "QnrB22 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii.", "model_sequences": {"$update": {"sequence": {"$update": {"689": {"$update": {"dna_sequence": {"$update": {"accession": "FJ981621.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB22"}}, "1173": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1959": {"$update": {"dna_sequence": {"$update": {"accession": "AF104442.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-54"}}, "1172": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1925": {"$update": {"dna_sequence": {"$update": {"accession": "HQ425492.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-194"}}, "1171": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"410": {"$update": {"dna_sequence": {"$update": {"accession": "FN594949.1"}}}}}}}}, "model_name": "tet(44)"}, "$insert": {"CARD_short_name": "tet(44)"}}, "1170": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1738": {"$update": {"dna_sequence": {"$update": {"accession": "FN556186.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-46"}}, "4251": {"$insert": {"CARD_short_name": "ADC-186"}}, "4250": {"$insert": {"CARD_short_name": "ADC-185"}}, "4253": {"$insert": {"CARD_short_name": "ADC-188"}}, "4252": {"$insert": {"CARD_short_name": "ADC-187"}}, "4255": {"$insert": {"CARD_short_name": "ADC-190"}}, "4254": {"$insert": {"CARD_short_name": "ADC-189"}}, "1179": {"$update": {"ARO_description": "IMP-4 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1785": {"$update": {"dna_sequence": {"$update": {"accession": "AF244145.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-4"}}, "1178": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"823": {"$update": {"dna_sequence": {"$update": {"accession": "JQ733578.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-81"}}, "5533": {"$insert": {"CARD_short_name": "PDC-403"}}, "5532": {"$insert": {"CARD_short_name": "PDC-402"}}, "5531": {"$insert": {"CARD_short_name": "PDC-401"}}, "5530": {"$insert": {"CARD_short_name": "PDC-400"}}, "5537": {"$insert": {"CARD_short_name": "PDC-407"}}, "5536": {"$insert": {"CARD_short_name": "PDC-406"}}, "5535": {"$insert": {"CARD_short_name": "PDC-405"}}, "5534": {"$insert": {"CARD_short_name": "PDC-404"}}, "5539": {"$insert": {"CARD_short_name": "PDC-409"}}, "5538": {"$insert": {"CARD_short_name": "PDC-408"}}, "1005": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2074": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Ecol_soxR_MULT"}}, "1285": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"584": {"$update": {"dna_sequence": {"$update": {"accession": "AB211124.1"}}}}}}}}, "model_name": "SAT-2"}, "$insert": {"CARD_short_name": "SAT-2"}}, "1284": {"$update": {"ARO_description": "IND-15 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1987": {"$update": {"dna_sequence": {"$update": {"accession": "AB563173.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-15"}}, "1287": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1665": {"$update": {"dna_sequence": {"$update": {"accession": "JF274242.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-110"}}, "512": {"$update": {"ARO_description": "CTX-M-82 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1088": {"$update": {"dna_sequence": {"$update": {"accession": "DQ256091.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-82"}}, "1281": {"$update": {"ARO_description": "OXA-110 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1600": {"$update": {"dna_sequence": {"$update": {"accession": "EF650036.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-110"}}, "1280": {"$update": {"ARO_description": "QnrB12  is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii.", "model_sequences": {"$update": {"sequence": {"$update": {"176": {"$update": {"dna_sequence": {"$update": {"accession": "AM774474.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB12"}}, "1283": {"$update": {"ARO_description": "KPC-6 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1437": {"$update": {"dna_sequence": {"$update": {"accession": "EU555534.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-6"}}, "1282": {"$update": {"ARO_description": "SIM-1 is an integron-encoded Ambler class B beta-lactamase isolated from Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1152": {"$update": {"dna_sequence": {"$update": {"accession": "GQ288397.1"}}}}}}}}, "model_name": "SIM-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SIM-1"}}, "2819": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics.", "ARO_category": {"$update": {"41323": {"$update": {"category_aro_description": "Point mutations in the 23S rRNA subunit may confer resistance to oxazolidinone antibiotics."}}}}}, "$insert": {"CARD_short_name": "Ecol_23S_OXZ"}}, "515": {"$update": {"model_sequences": {"$update": {"sequence": {"8170": {"dna_sequence": {"partial": "0", "sequence": "ATGAAGCGAAAAGAGTTGCACGAGACGTCTCGTCTCGCATACGGTCGTCGCATGACCACTCGCCCCGCGCACATCGCCATGTTCTCCATCGCCCTGCACGGCCACGTGAACCCCAGCCTGGAGGTCATCCGCGAGCTCGTCGCGCGGGGGCACCGGGTGACGTACGCGATCCCGCCGCTCCTCGCGGACAAGGTCGCCGAGGCGGGCGCCGAACCCAAGCTCTGGAACAGCACACTGCCCGGCCCCGACGCCGACCCGGAGGCCTGGGGGAGCACCCTCCTGGACAACGTGGAGCCCTTCCTCGCCGACGCGATCCAGTCGCTCCCGCAGCTCGCCCAGGCGTACGAGGGGGACGAGCCGGACCTGGTCCTGCACGACATCGCCTCCTACACCGCCCGCGTCCTGGGCCGCCGCTGGGAGGTGCCCGTGATCTCCCTGTCGCCCTGCATGGTCGCCTGGGAGGGGTACGAGCAGGAGGTCGGCGAGCCGATGTGGGAGGAGCCGCGGAAGACCGAGCGCGGGCAGGCGTACTACGCCCGCTTCCACGCCTGGCTGGAGGAGAACGGGATCACCGACCACCCCGACCCGTTCATCGGCCGCCCCGACCGCTCCCTGGTGCTGATCCCCAAGGCGCTCCAGCCCCACGCCGACCGGGTGGACGAGACGACGTACACCTTCGTCGGCGCCTGCCAGGGGGACCGCACCGCCGAGGGCGACTGGGCCCGTCCCGAGGGCGCGGAGAAGGTCGTCCTGGTCTCGCTCGGTTCGGCCTTCACCAAGCAGCCCGCGTTCTACCGGGAGTGCGTCCGGGCCTTCGGTGAGCTGCCCGGCTGGCACACCGTGCTCCAGGTCGGCCGGCACGTAGACCCGGCCGAGCTGGGCGACGTACCGGACAACGTGGAAGTCCGCACGTGGGTACCGCAGTTGGCGATCCTCCAGCAGGCCGACCTGTTCGTCACCCACGCGGGCGCGGGCGGCAGCCAGGAGGGTCTGGCCACCGCCACGCCGATGATCGCCGTACCGCAGGCCGCGGACCAGTTCGGCAACGCCGACATGCTCCAGGGCCTCGGCGTCGCCCGCACCCTCCCGACCGAGGAGGCCACCGCGAAGGCGCTGCGCACCGCCGCCCTCGCCCTGGTCGACGACCCGGAGGTGGCGGCGCGCCTGAAGGAGATCCAGGCGCGGATGGCCCAGGAGGGCGGCACCCGCCGGGCCGCCGACCTCATCGAGGCCGAACTGGCCGCCGCGCGCGGCTGA", "fmax": "1257", "accession": "DQ185434.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces lividans", "NCBI_taxonomy_id": "1916", "NCBI_taxonomy_cvterm_id": "39569"}, "protein_sequence": {"accession": "ABA28305.2", "sequence": "MKRKELHETSRLAYGRRMTTRPAHIAMFSIALHGHVNPSLEVIRELVARGHRVTYAIPPLLADKVAEAGAEPKLWNSTLPGPDADPEAWGSTLLDNVEPFLADAIQSLPQLAQAYEGDEPDLVLHDIASYTARVLGRRWEVPVISLSPCMVAWEGYEQEVGEPMWEEPRKTERGQAYYARFHAWLEENGITDHPDPFIGRPDRSLVLIPKALQPHADRVDETTYTFVGACQGDRTAEGDWARPEGAEKVVLVSLGSAFTKQPAFYRECVRAFGELPGWHTVLQVGRHVDPAELGDVPDNVEVRTWVPQLAILQQADLFVTHAGAGGSQEGLATATPMIAVPQAADQFGNADMLQGLGVARTLPTEEATAKALRTAALALVDDPEVAARLKEIQARMAQEGGTRRAADLIEAELAAARG"}}}}}}, "$insert": {"CARD_short_name": "mgtA"}}, "1050": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"172": {"$update": {"dna_sequence": {"$update": {"accession": "L12710.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ii"}}, "3565": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BRO-1"}}, "1289": {"$update": {"ARO_description": "OKP-B-7 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1831": {"$update": {"dna_sequence": {"$update": {"accession": "AM051156.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-7"}}, "1288": {"$update": {"ARO_description": "OXA-82 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1846": {"$update": {"dna_sequence": {"$update": {"accession": "EU019536.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-82"}}, "514": {"$update": {"ARO_description": "LEN-10 is a beta-lactamase found in Klebsiella pneumoniae.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-10"}}, "3430": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-263"}}, "1579": {"$update": {"ARO_description": "QnrB9 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"681": {"$update": {"dna_sequence": {"$update": {"accession": "EF526508.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB9"}}, "1578": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1773": {"$update": {"dna_sequence": {"$update": {"accession": "GQ390805.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-123"}}, "689": {"$update": {"ARO_description": "CTX-M-123 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1254": {"$update": {"dna_sequence": {"$update": {"accession": "JN790864.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-123"}}, "688": {"$update": {"ARO_description": "MOX-2 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1039": {"$update": {"dna_sequence": {"$update": {"accession": "AJ276453.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-2"}}, "3431": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5627": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Acinetobacter haemolyticus CIP 64.3 = MTCC 9819"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-264"}}, "685": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1529": {"$update": {"dna_sequence": {"$update": {"accession": "JQ837239.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-239"}}, "684": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1475": {"$update": {"dna_sequence": {"$update": {"accession": "AF467948.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-37"}}, "687": {"$update": {"ARO_description": "APH(3')-Vc is a chromosomal-encoded aminoglycoside phosphotransferase in M. chalcea.", "model_sequences": {"$update": {"sequence": {"$update": {"470": {"$update": {"dna_sequence": {"$update": {"accession": "S81599.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-Vc"}}, "686": {"$update": {"ARO_description": "OXA-162 is a beta-lactamase found in Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"967": {"$update": {"dna_sequence": {"$update": {"accession": "HM015773.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-162"}}, "681": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1072": {"$update": {"dna_sequence": {"$update": {"accession": "AY243512.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-120"}}, "680": {"$update": {"ARO_description": "CMY-54 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1036": {"$update": {"dna_sequence": {"$update": {"accession": "HM544039.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-54"}}, "683": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1587": {"$update": {"dna_sequence": {"$update": {"accession": "JQ733572.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-75"}}, "682": {"$update": {"ARO_description": "QnrS4 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"212": {"$update": {"dna_sequence": {"$update": {"accession": "FJ418153.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS4"}}, "4189": {"$insert": {"CARD_short_name": "ADC-115"}}, "3433": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-266"}}, "2818": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Streptomyces ambofaciens shown to confer resistance to macrolide type antibiotics.", "model_name": "Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics"}, "$insert": {"CARD_short_name": "Samb_23S_MAC"}}, "1226": {"$insert": {"CARD_short_name": "adeG"}}, "995": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}, "model_name": "MexG"}, "$insert": {"CARD_short_name": "MexG"}}, "3434": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-267"}}, "1240": {"$insert": {"CARD_short_name": "mphL"}}, "621": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"593": {"$update": {"dna_sequence": {"$update": {"accession": "M17124.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmF"}}, "873": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"954": {"$update": {"dna_sequence": {"$update": {"accession": "KJ775801.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-19"}}, "1224": {"$insert": {"CARD_short_name": "Erm(30)"}}, "3436": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-269"}}, "627": {"$update": {"ARO_description": "Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin."}, "$insert": {"CARD_short_name": "Ecol_rpoB_RIF"}}, "3437": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-270"}}, "1888": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1102": {"$update": {"dna_sequence": {"$update": {"accession": "KM087858.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-10"}}, "1222": {"$update": {"model_name": "FosA"}, "$insert": {"CARD_short_name": "FosA"}}, "4592": {"$insert": {"CARD_short_name": "EC-18"}}, "4389": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6764": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-28"}}, "4388": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6763": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-27"}}, "1221": {"$update": {"ARO_description": "OXA-231 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"8258": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAAATTTATACTTCCTATTCTCAGCATTTCTACTCTACTTTCTGTCAGTGCATGCTCATCTATTCAAACTAAATTTGAAGACACTTTTCATACTTCTAATCAGCAACATGAAAAAGCCATTAAAAGCTATTTTGATGAAGCTCAAACACAGGGTGTAATCATTATTAAAAAGGGAAAAAATATTAGTACCTATGGTAATAACCTGACACGAGCACATACAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCCTTAATTGGACTAGAAAATCATAAAGCTACAACAACTGAGATTTTCAAATGGGACGGTAAAAAGAGATCTTATCCCATGTGGGAAAAAGATATGACTTTAGGTGATGCCATGGCACTTTCAGCAGTTCCTGTATATCAAGAACTTGCAAGACGGACTGGCTTAGACCTAATGCAAAAAGAAGTTAAACGGGTTGGTTTTGGTAATATGAACATTGGAACACAAGTTGATAACTTCTGGTTGGTTGGCCCCCTCAAGATTACACCAATACAAGAGGTTAATTTTGCCGATGATTTTGCAAATAATCGATTACCCTTTAAATTAGAGACTCAAGAAGAAGTTAAAAAAATGCTTCTGATTAAAGAATTCAATGGTAGTAAAATTTATGCAAAAAGCGGCTGGGGAATGGCTGTAACCCCTCAAGTAGGTTGGTTAACAGGTTGGGTAGAAAAATCTAATGGAGAAAAAGTTGCCTTTTCTCTAAACATAGAAATGAAGCAAGGAATGCCTGGTTCTATTCGTAATGAAATTACTTATAAATCATTAGAGAATTTAGGGATTATATAA", "fmax": "1021", "accession": "JQ326200.2", "fmin": "193", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "AFG29918.1", "sequence": "MKKFILPILSISTLLSVSACSSIQTKFEDTFHTSNQQHEKAIKSYFDEAQTQGVIIIKKGKNISTYGNNLTRAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEKDMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMNIGTQVDNFWLVGPLKITPIQEVNFADDFANNRLPFKLETQEEVKKMLLIKEFNGSKIYAKSGWGMAVTPQVGWLTGWVEKSNGEKVAFSLNIEMKQGMPGSIRNEITYKSLENLGII"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-231"}}, "5629": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8004": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "PLN-1"}}, "5628": {"$insert": {"CARD_short_name": "PLA-6"}}, "4383": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6758": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-22"}}, "4382": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-20"}}, "4381": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6756": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-2"}}, "4380": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-19"}}, "4387": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6762": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-26"}}, "5622": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7997": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "PFM-1"}}, "4385": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6760": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-24"}}, "4384": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-23"}}, "407": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1213": {"$update": {"dna_sequence": {"$update": {"accession": "KF297581.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-352"}}, "406": {"$update": {"ARO_description": "ACC-4 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8175": {"dna_sequence": {"partial": "0", "sequence": "ATGCAGAACACATTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGTCCAAGGTGCTCTGGCTGCTAATATCGATGAGAGCAAAATTAAAGACACCGTTGATGACCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCGTCAACGGTAAAAACTACATTTATAACTATGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTTACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCACCTTGGCGTCCTATGCGCAGGTGAGCGGTAAGCTGTCTTTGGATCAAAGCGTTAGCCATTACGTTCCAGAGTTGCGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGCACGCATACCTCAGGCCTACAGCTATTTATGCCGGAAGATATTAAAAATACCACACAGCTGATGGCTTATCTAAAAGCATGGAAACCTGCCGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACTGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGAAAACCCTCCTTCCTCAGTTAGGCATGCATCACAGCTACTTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGGGAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGCGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGCTAATGCCAAGATGCAACAGGCTCTGACAGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCGGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCGCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAGCGAGTGACGGTGGCGTATAAAATCCTGAGCTCATTGGAAGGGAATAAGTAG", "fmax": "3155", "accession": "EF504260.2", "fmin": "1994", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ABP49606.1", "sequence": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHGNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-4"}}, "405": {"$update": {"ARO_description": "OXA-202 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1454": {"$update": {"dna_sequence": {"$update": {"accession": "HQ734813.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-202"}}, "1372": {"$update": {"ARO_description": "Plasmid or integron-encoded nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 2'' in P. aeruginosa, K. pneumoniae, Morganella morganii, E. coli, S. typhimurium, C. freundii and A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"457": {"$update": {"dna_sequence": {"$update": {"accession": "AF078527.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ANT(2'')-Ia"}}, "1375": {"$update": {"ARO_description": "CMY-11 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1857": {"$update": {"dna_sequence": {"$update": {"accession": "AF357599.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-11"}}, "402": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3343": {"$update": {"dna_sequence": {"$update": {"accession": "AF070999.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(Y)"}}, "1377": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1966": {"$update": {"dna_sequence": {"$update": {"accession": "AM411407.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-60"}}, "400": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1308": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666065.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PDC-1"}}, "1379": {"$update": {"ARO_description": "OXA-313 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1376": {"$update": {"dna_sequence": {"$update": {"accession": "KF057030.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-313"}}, "1378": {"$update": {"ARO_description": "AAC(3)-IIc is a plasmid-encoded aminoglycoside acetyltransferase in E. coli and P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"616": {"$update": {"dna_sequence": {"$update": {"accession": "X54723.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-IIc"}}, "4183": {"$insert": {"CARD_short_name": "ADC-107"}}, "409": {"$update": {"ARO_description": "Also known as vanRL, is a vanR variant found in the vanL gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"287": {"$update": {"dna_sequence": {"$update": {"accession": "EU250284.1"}}}}}}}}, "model_name": "vanR gene in vanL cluster", "ARO_name": "vanR gene in vanL cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanL_cl"}}, "408": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4501": {"$update": {"dna_sequence": {"$update": {"accession": "KF986261.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-380"}}, "3834": {"$update": {"ARO_description": "Mutations in Mycobacterium tuberculosis katG conferring resistance to prothionamide, an analogue of isoniazid.", "ARO_category": {"$update": {"43316": {"$update": {"category_aro_description": "Mutations associated with katG conferring resistance to prothionamide, an analogue of isoniazid. Like isoniazid, prothionamide targets lnhA."}}}}}, "$insert": {"CARD_short_name": "Mtub_katG_PTO"}}, "3836": {"$update": {"ARO_description": "Mutations in Mycobacterium tuberculosis ethA conferring resistance to isoniazid.", "ARO_category": {"$update": {"43318": {"$update": {"category_aro_description": "Mutations in ethA conferring resistance to isoniazid."}}}}}, "$insert": {"CARD_short_name": "Mtub_ethA_INH"}}, "4182": {"$insert": {"CARD_short_name": "ADC-106"}}, "3830": {"$update": {"ARO_description": "A subunit of the qac multidrug efflux pump in Vibrio cholerae.", "model_sequences": {"$update": {"sequence": {"$update": {"6142": {"$update": {"protein_sequence": {"$update": {"accession": "AAZ42322.1"}}}}}}}}, "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}}, "$insert": {"CARD_short_name": "qacL"}}, "3831": {"$insert": {"CARD_short_name": "Spyo_ErmA_MLSb"}}, "3832": {"$insert": {"CARD_short_name": "FosB2"}}, "454": {"$update": {"ARO_description": "KPC-4 is a beta-lactamase found in Klebsiella pneumoniae.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-4"}}, "2148": {"$update": {"ARO_description": "Point mutation in Ureaplasma urealyticum resulting in fluoroquinolone resistance.", "model_name": "Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones", "ARO_name": "Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Uure_gyrB_FLO"}}, "3838": {"$update": {"ARO_description": "Mutations in Mycobacterium tuberculosis mshA conferring resistance to prothionamide, an analogue to isoniazid.", "ARO_category": {"$update": {"43322": {"$update": {"category_aro_description": "Mutations in mshA conferring resistance to prothionamide, an analogue of isoniazid."}}}}}, "$insert": {"CARD_short_name": "Mtub_mshA_PTO"}}, "3839": {"$update": {"ARO_description": "Predominant beta-lactamase in Mycolicibacterium smegmatis.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43325": {"$update": {"category_aro_description": "A class A beta-lactamase in Mycolicibacterium smegmatis."}}}}}, "$insert": {"CARD_short_name": "blaS1"}}, "1345": {"$insert": {"CARD_short_name": "tet(K)"}}, "4031": {"$update": {"ARO_description": "PDC-183 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-183"}}, "2749": {"$insert": {"CARD_short_name": "lnuG"}}, "4033": {"$update": {"ARO_description": "PDC-306 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-306"}}, "4032": {"$update": {"ARO_description": "PDC-207 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-207"}}, "4035": {"$update": {"ARO_description": "PDC-117 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-117"}}, "4187": {"$insert": {"CARD_short_name": "ADC-113"}}, "4037": {"$update": {"ARO_description": "PDC-104 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-104"}}, "2748": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "oqxAB"}}, "4039": {"$update": {"ARO_description": "PDC-292 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-292"}}, "4038": {"$update": {"ARO_description": "PDC-173 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-173"}}, "4186": {"$insert": {"CARD_short_name": "ADC-112"}}, "4846": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-511"}}, "4847": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-512"}}, "379": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1679": {"$update": {"dna_sequence": {"$update": {"accession": "GQ853679.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-148"}}, "378": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2126": {"$update": {"dna_sequence": {"$update": {"accession": "KP050491.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-214"}}, "5427": {"$insert": {"CARD_short_name": "PDC-297"}}, "4842": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-507"}}, "371": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"993": {"$update": {"dna_sequence": {"$update": {"accession": "U92041.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-8"}}, "373": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1810": {"$update": {"dna_sequence": {"$update": {"accession": "AY743435.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-3"}}, "372": {"$update": {"ARO_description": "qacA is a subunit of the qac multidrug efflux pump.", "model_sequences": {"$update": {"sequence": {"$update": {"265": {"$update": {"dna_sequence": {"$update": {"accession": "AB566411.1"}}}}}}}}}, "$insert": {"CARD_short_name": "qacA"}}, "375": {"$update": {"ARO_description": "Multidrug resistance protein MdtH.", "model_sequences": {"$update": {"sequence": {"$update": {"4493": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}}, "$insert": {"CARD_short_name": "mdtH"}}, "374": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1391": {"$update": {"dna_sequence": {"$update": {"accession": "AF117745.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-21"}}, "377": {"$insert": {"CARD_short_name": "mepA"}}, "376": {"$update": {"ARO_description": "lnuC is a transposon-mediated nucleotidyltransferase found in Streptococcus agalactiae.", "model_sequences": {"$update": {"sequence": {"$update": {"110": {"$update": {"dna_sequence": {"$update": {"accession": "AY928180.1"}}}}}}}}}, "$insert": {"CARD_short_name": "lnuC"}}, "4739": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-80"}}, "5665": {"$insert": {"CARD_short_name": "SST-1"}}, "1987": {"$update": {"ARO_description": "QnrA1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"403": {"$update": {"dna_sequence": {"$update": {"accession": "DQ831141.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrA1"}}, "5664": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8039": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SRT-3"}}, "393": {"$update": {"ARO_description": "QnrS5 is a plasmid-mediated quinolone resistance protein found in Aeromonas sobria.", "model_sequences": {"$update": {"sequence": {"$update": {"254": {"$update": {"dna_sequence": {"$update": {"accession": "HQ631377.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS5"}}, "392": {"$update": {"ARO_description": "TUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus.", "model_sequences": {"$update": {"sequence": {"$update": {"1163": {"$update": {"dna_sequence": {"$update": {"accession": "AF441287.1"}}}}}}}}, "model_name": "TUS-1", "ARO_category": {"$update": {"41369": {"$update": {"category_aro_description": "TUS beta-lactamases are Class B beta-lactamases that can hydrolyze a variety of beta-lactams, such as cephems and carbapenems."}}}}}, "$insert": {"CARD_short_name": "TUS-1"}}, "391": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1577": {"$update": {"dna_sequence": {"$update": {"accession": "EF614235.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-2"}}, "390": {"$update": {"ARO_description": "Also known as vanSG, is a vanS variant found in the vanG gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"706": {"$update": {"dna_sequence": {"$update": {"accession": "DQ212986.1"}}}}}}}}, "model_name": "vanS gene in vanG cluster", "ARO_name": "vanS gene in vanG cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanG_cl"}}, "397": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1611": {"$update": {"dna_sequence": {"$update": {"accession": "KF421160.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-357"}}, "396": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4494": {"$update": {"dna_sequence": {"$update": {"accession": "FJ196385.1"}}}}}}}}}, "$insert": {"CARD_short_name": "sul3"}}, "395": {"$update": {"ARO_description": "Class A beta-lactamase found in Mycolicibacterium fortuitum.", "model_sequences": {"$update": {"sequence": {"$update": {"3317": {"$update": {"dna_sequence": {"$update": {"accession": "L25634.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "blaF"}}, "394": {"$update": {"ARO_description": "OXA-130 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1601": {"$update": {"dna_sequence": {"$update": {"accession": "EU547445.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-130"}}, "399": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1581": {"$update": {"dna_sequence": {"$update": {"accession": "KM087861.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-16"}}, "398": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1574": {"$update": {"dna_sequence": {"$update": {"accession": "AF203816.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-71"}}, "5669": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-99"}}, "1560": {"$update": {"ARO_description": "OKP-B-20 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8261": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAAGTCAGCTGGCGGGCCGTGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACACCGCCGGCAATCTGCTGTTGAAGATCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGCTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTTGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGTGATACCGCGGCGACCATGGTCGAGCGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "885", "accession": "AM850922.2", "fmin": "24", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12360.2", "sequence": "MRYVRLCLISLIAALPLAVFASPQPLEQIKISESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNTAGNLLLKIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTAATMVERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-20"}}, "2308": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}, "model_name": "Acinetobacter baumannii OprD conferring resistance to imipenem"}, "$insert": {"CARD_short_name": "Abau_OprD_IPM"}}, "5668": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-98"}}, "4729": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-66"}}, "4728": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-65"}}, "2301": {"$update": {"ARO_category": {"$update": {"40483": {"$update": {"category_aro_description": "Mutations to the YybT gene confers daptomycin resistance."}}}}}, "$insert": {"CARD_short_name": "Efae_YybT_DAP"}}, "2300": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "Acinetobacter baumannii ampC beta-lactamase"}, "$insert": {"CARD_short_name": "Abau_ampC_BLA"}}, "2303": {"$update": {"ARO_description": "Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene."}, "$insert": {"CARD_short_name": "bcr-1"}}, "4726": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-63"}}, "2305": {"$insert": {"CARD_short_name": "Efae_gshF_DAP"}}, "4720": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-44"}}, "2307": {"$update": {"ARO_category": {"$update": {"40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}, "model_name": "carO"}, "$insert": {"CARD_short_name": "carO"}}, "4722": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-59"}}, "5527": {"$insert": {"CARD_short_name": "PDC-398"}}, "4696": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-70"}}, "453": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"400": {"$update": {"dna_sequence": {"$update": {"accession": "X95635.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mtrE"}}, "2746": {"$update": {"ARO_accession": "3004082", "ARO_description": "AcrAD-TolC efflux pump system in E. coli from the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides.", "ARO_category": {"$delete": ["35933", "35932", "35969"]}, "ARO_name": "AcrAD-TolC", "model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_id": "41184", "model_name": "AcrAD-TolC"}, "$insert": {"CARD_short_name": "AcrAD-TolC"}}, "1500": {"$update": {"ARO_description": "APH(6)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus.", "model_sequences": {"$update": {"sequence": {"$update": {"94": {"$update": {"dna_sequence": {"$update": {"accession": "Y00459.1"}}}}}}}}, "ARO_category": {"$update": {"36290": {"$update": {"category_aro_description": "Phosphorylation of streptomycin on the hydroxyl group at position 6."}}}}}, "$insert": {"CARD_short_name": "APH(6)-Ia"}}, "471": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"998": {"$update": {"dna_sequence": {"$update": {"accession": "DQ834729.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-151"}}, "3745": {"$insert": {"CARD_short_name": "Mtub_23S_CAP"}}, "245": {"$update": {"ARO_description": "cmlA5 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"695": {"$update": {"dna_sequence": {"$update": {"accession": "AY115475.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cmlA5"}}, "244": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"988": {"$update": {"dna_sequence": {"$update": {"accession": "HE981194.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-164"}}, "247": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1569": {"$update": {"dna_sequence": {"$update": {"accession": "EF534736.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-158"}}, "246": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1476": {"$update": {"dna_sequence": {"$update": {"accession": "AB703103.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-126"}}, "241": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1263": {"$update": {"dna_sequence": {"$update": {"accession": "KM087833.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-30"}}, "240": {"$update": {"ARO_description": "Also known as vanRF, is a vanR variant found in the vanF gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"202": {"$update": {"dna_sequence": {"$update": {"accession": "AF155139.1"}}}}}}}}, "model_name": "vanR gene in vanF cluster", "ARO_name": "vanR gene in vanF cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanF_cl"}}, "243": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1219": {"$update": {"dna_sequence": {"$update": {"accession": "M55547.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-9"}}, "242": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1232": {"$update": {"dna_sequence": {"$update": {"accession": "JX121119.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-152"}}, "4628": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-45"}}, "4629": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-46"}}, "249": {"$update": {"ARO_description": "Histidine protein kinase sensor Lipid A modification gene; part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+).", "model_sequences": {"$update": {"sequence": {"$update": {"3375": {"$update": {"dna_sequence": {"$update": {"accession": "JQ340365.1"}}}}}}}}}, "$insert": {"CARD_short_name": "basS"}}, "248": {"$update": {"ARO_description": "OKP-B-9 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1998": {"$update": {"dna_sequence": {"$update": {"accession": "AM051159.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-9"}}, "2274": {"$update": {"ARO_category": {"$update": {"37697": {"$update": {"category_aro_description": "Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides."}}}}}, "$insert": {"CARD_short_name": "RlmA(II)"}}, "2277": {"$insert": {"CARD_short_name": "mphM"}}, "2276": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3538": {"$update": {"dna_sequence": {"$update": {"accession": "X74219.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Saur_ileS_MUP"}}, "2271": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3524": {"$update": {"dna_sequence": {"$update": {"accession": "JQ231224.1"}}, "protein_sequence": {"$update": {"accession": "AEY83581.1"}}}}}}}}, "model_name": "Staphylococcus aureus mupB conferring resistance to mupirocin"}, "$insert": {"CARD_short_name": "Saur_mupB_MUP"}}, "2270": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3523": {"$update": {"dna_sequence": {"$update": {"accession": "X75439.1"}}, "protein_sequence": {"$update": {"accession": "CAA53189.1"}}}}}}}}, "model_name": "Staphylococcus aureus mupA conferring resistance to mupirocin"}, "$insert": {"CARD_short_name": "Saur_mupA_MUP"}}, "2272": {"$update": {"ARO_description": "Cardiolipin synthase (cls) is an inner membrane protein involved in membrane synthesis and phosopholipid metabolism, with mutations to the gene being capable of conferring daptomycin resistance.", "model_name": "Enterococcus faecalis cls with mutation conferring resistance to daptomycin"}, "$insert": {"CARD_short_name": "Efae_cls_DAP"}}, "2404": {"$update": {"ARO_description": "Point mutation in Neisseria gonorrhoeae DNA gyrase subunit A. Decreases affinity between fluoroquinolone antibiotic molecule and gyrA, thereby conferring resistance to fluoroquinolone."}, "$insert": {"CARD_short_name": "Ngon_gyrA_FLO"}}, "2279": {"$insert": {"CARD_short_name": "Lmon_mprF"}}, "2278": {"$update": {"model_name": "Bifidobacterium bifidum ileS conferring resistance to mupirocin"}, "$insert": {"CARD_short_name": "Bbif_ileS_MUP"}}, "5543": {"$insert": {"CARD_short_name": "PDC-414"}}, "5206": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-914"}}, "1734": {"$update": {"ARO_description": "IND-4 is a beta-lactamase found in Chryseobacterium indologenes.", "model_sequences": {"$update": {"sequence": {"8199": {"dna_sequence": {"partial": "0", "sequence": "ATGAGGAAAAATGTTAGGATTTTTACTGTGTTGTCTCTGTTCTTAATTAATTTTTTTAATGCGCAGGCCCGTGACTTTGTAATTGAGCAGCCTTTTGGCAAACAACTTTATCTGTATAAAACCTTCGGAGTTTTTGACGGCAAAGAATATTCAACCAATGCGCTTTATCTGGTCACTAAAAAAGGAGTAGTCCTTTTTGATGTCCCATGGCAGAAAACCCAGTATCAAAGTCTTATGGATACGATAAAGAAACGTCATAACTTACCGGTGATCGCTGTATTTGCAACACATTCACACTCAGACAGAGCCGGAGACCTGAGTTTTTACAATAAAAAAGGCATCCCGACCTATGCCACGGCCAAAACCAATGAACTGCTGAAGAAAGAAGGAAAAGCAACTTCCAGTAAATTAACAAAGATTGGAAAGAAATATAAAATAGGCGGTGAAGAATTCACTGTAGACTTCTTAGGTGAAGGTCACACAGCAGATAACGTGGTGGTTTGGTTTCCAAAATATAACGTCCTGGACGGTGGCTGCTTAGTGAAAAGCAGTGCAGCAGTTGATCTTGGATATACAGGAGAAGCTAATGTAGAACAATGGCCGGCAACCATGAAAAAGCTGCAGGCTAAATACCCCTCCACTGCAAAGGTAATTCCGGGACACGACGAGTGGAAAGGCAACGACCATGTAAAACATACACTGGAGCTTTTAGATCAACAAAAACAGTAG", "fmax": "729", "accession": "AF219135.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Chryseobacterium indologenes", "NCBI_taxonomy_id": "253", "NCBI_taxonomy_cvterm_id": "36916"}, "protein_sequence": {"accession": "AAG29765.2", "sequence": "MRKNVRIFTVLSLFLINFFNAQARDFVIEQPFGKQLYLYKTFGVFDGKEYSTNALYLVTKKGVVLFDVPWQKTQYQSLMDTIKKRHNLPVIAVFATHSHSDRAGDLSFYNKKGIPTYATAKTNELLKKEGKATSSKLTKIGKKYKIGGEEFTVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSSAAVDLGYTGEANVEQWPATMKKLQAKYPSTAKVIPGHDEWKGNDHVKHTLELLDQQKQ"}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-4"}}, "971": {"$update": {"ARO_description": "cmlA4 is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"656": {"$update": {"dna_sequence": {"$update": {"accession": "AF156486.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cmlA4"}}, "2155": {"$insert": {"CARD_short_name": "Cacn_16S_TET"}}, "179": {"$update": {"ARO_description": "QnrA5 is a plasmid-mediated quinolone resistance protein found in Shewanella algae.", "model_sequences": {"$update": {"sequence": {"$update": {"588": {"$update": {"dna_sequence": {"$update": {"accession": "DQ058663.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrA5"}}, "178": {"$update": {"ARO_description": "Also known as vanHA, is a vanH variant in the vanA gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3279": {"$update": {"dna_sequence": {"$update": {"accession": "M97297.1"}}}}}}}}, "model_name": "vanH gene in vanA cluster", "ARO_name": "vanH gene in vanA cluster"}, "$insert": {"CARD_short_name": "vanH_in_vanA_cl"}}, "177": {"$update": {"ARO_description": "From Lahey's list of beta-lactamases, no additional information available.", "model_sequences": {"$update": {"sequence": {"$update": {"2108": {"$update": {"dna_sequence": {"$update": {"accession": "LC031883.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-51"}}, "176": {"$update": {"ARO_description": "CMY-25 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1282": {"$update": {"dna_sequence": {"$update": {"accession": "EU515249.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-25"}}, "175": {"$update": {"ARO_description": "CTX-M-24 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1477": {"$update": {"dna_sequence": {"$update": {"accession": "AY143430.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-24"}}, "174": {"$update": {"ARO_description": "CfxA2 beta-lactamase is a class A beta-lactamase found in Prevotella intermedia.", "ARO_category": {"$update": {"39434": {"$update": {"category_aro_description": "CfxA beta-lactamases are class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "CfxA2"}}, "173": {"$update": {"ARO_description": "arr-4 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"524": {"$update": {"dna_sequence": {"$update": {"accession": "EF660562.1"}}}}}}}}}, "$insert": {"CARD_short_name": "arr-4"}}, "172": {"$insert": {"CARD_short_name": "OprN"}}, "171": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2038": {"$update": {"dna_sequence": {"$update": {"accession": "AF190693.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-78"}}, "170": {"$update": {"ARO_description": "IMP-19 is a beta-lactamase found in Aeromonas caviae.", "model_sequences": {"$update": {"sequence": {"$update": {"1014": {"$update": {"dna_sequence": {"$update": {"accession": "EF118171.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-19"}}, "2051": {"$update": {"ARO_description": "dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae.", "model_sequences": {"$update": {"sequence": {"$update": {"2102": {"$update": {"dna_sequence": {"$update": {"accession": "KF534911.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA15"}}, "2050": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1459": {"$update": {"dna_sequence": {"$update": {"accession": "KF203105.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-3"}}, "2054": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"363": {"$update": {"dna_sequence": {"$update": {"accession": "AF313494.1"}}}}}}}}}, "$insert": {"CARD_short_name": "msrC"}}, "2057": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1559": {"$update": {"dna_sequence": {"$update": {"accession": "KF705208.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-44"}}, "1977": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"541": {"$update": {"dna_sequence": {"$update": {"accession": "L29510.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ik"}}, "4656": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-43"}}, "2796": {"$update": {"model_sequences": {"$update": {"sequence": {"8185": {"dna_sequence": {"partial": "0", "sequence": "ATGAAACCCGTGGCAATGACCCTGCTGGCGCTGGCATTGTCCGGCTGCTCGCTGGCGCCCACCCATGAGCGCCCCGCGGCGCCGGTGCCGGCGCAGTACGACACGCCGGCGCAGCCCGGCCAGGCCGCCGCGCCGCAGGACTGGCGCGCCTATTTCAACGATCCGGCGCTGCAGGCCTGGATCGCGGCCGCGCTGGCCAACAACCGCGACCTGCGCGTGGCGGCGCTGCGCATCGAGGAAGCGCGCGCGCTGTACGGCGTGCAGCAATCCGAACGCCTGCCGGCCATCGACGCCAGCGGCGAATTCAGCCGCGGCCGCGCGACCGAGCCGGGCCAGCCGCGCACGCCGGTGTCCAACCGCTACCGCGCGGCCGTCGGCATCACCGCGTTCGAGCTGGACTTCTTCGGCCGGGTGCGGAGCCTGTCGGACGCCGCGCTGGCGCGCTACCTGGCCAGCGAGGAAGCGCACCGCGCCGCCACGCTGGCGCTGGTGGCGGAGACGGCGACGGCCTACTTCAACCAGCGTTCGCTGGCCGAGCAACTGCGCCTGACCGACGACACGCTGGCGCTGCGCGAGACCACGCTCAAGCTGACCCAGCGCCGCTACGACGCCGGGCTGGAAACCGCCATCGGCCTGCGCACCGCGCAGATGCTGGTGGAAAGCTCGCGCGCCACGCGCGCCGAGCTGACCCGCGAGGCCAGCCTGGCGCGGCACGCGCTGGGCCTGCTGGCCGGCGATTTCGCGCTGCCGCTCGGCGTCGACCCTACGCCGCTGGAAAGCCAGAGCCTGACGCCGCTGGCGGCGGGGCTGCCGTCCGAACTGCTGACGCGCCGCCCCGACCTGCGCCAGGCAGAGCAGGCGCTGCGCGCGGCCAACGCCGACATCGGCGCGGCGCGCGCGGCGTTCTTCCCGTCGGTGCAGCTGACCACGGACATCGGCACCACCGCCGACCGCTTCTCGGATCTGTTCAGCGGCGGCACCGGCGGCTGGAGCTTCGCGCCGCGCCTGACGCTGCCGATCTTCAACGCCGGCCGCAACCGCGCCAACCTGTCGCTGGCCGAGACCCGCAAGCACATCGCGGTGGCCCAGTACGAAGGCAGCATCCAGGCCGCGTTCCGCGACGTGGCCGACGCGCTGTCGGCGCGCGACGCGCTGCGCGACCAGATCGAGGCCCAGCGCAAGGTGCGCGACGCCGACCGCGAACGCCAGCGGCTGGCCGAGCGGCGTTATGCGCGCGGGGTGGCGAACTACCTGGAGATGCTGGAGGCCCAGCGCAGCCTGTTCGAGTCGGAACAGGAATTCATCCGGCTGCAGCAGCGCCGGCTGGTCAACGCGGTGGATCTGTACAAGGCGCTGGGCGGCTGGGACGACGGCTCATCGCCGGCGTCCTGA", "fmax": "23990", "accession": "AFRQ01000061.1", "fmin": "22598", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Achromobacter insuavis AXX-A", "NCBI_taxonomy_id": "1003200", "NCBI_taxonomy_cvterm_id": "41271"}, "protein_sequence": {"accession": "EGP45230.2", "sequence": "MKPVAMTLLALALSGCSLAPTHERPAAPVPAQYDTPAQPGQAAAPQDWRAYFNDPALQAWIAAALANNRDLRVAALRIEEARALYGVQQSERLPAIDASGEFSRGRATEPGQPRTPVSNRYRAAVGITAFELDFFGRVRSLSDAALARYLASEEAHRAATLALVAETATAYFNQRSLAEQLRLTDDTLALRETTLKLTQRRYDAGLETAIGLRTAQMLVESSRATRAELTREASLARHALGLLAGDFALPLGVDPTPLESQSLTPLAAGLPSELLTRRPDLRQAEQALRAANADIGAARAAFFPSVQLTTDIGTTADRFSDLFSGGTGGWSFAPRLTLPIFNAGRNRANLSLAETRKHIAVAQYEGSIQAAFRDVADALSARDALRDQIEAQRKVRDADRERQRLAERRYARGVANYLEMLEAQRSLFESEQEFIRLQQRRLVNAVDLYKALGGWDDGSSPAS"}}}}}}, "$insert": {"CARD_short_name": "OprZ"}}, "2697": {"$insert": {"CARD_short_name": "EdeQ"}}, "4651": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-38"}}, "2695": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "MexCD-OprJ with type B NfxB mutation"}, "$insert": {"CARD_short_name": "Paer_NfxBb_MULT"}}, "2694": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "MexCD-OprJ with type A NfxB mutation"}, "$insert": {"CARD_short_name": "Paer_NfxBa_MULT"}}, "2693": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Type_B_NfxB"}}, "1975": {"$update": {"ARO_description": "blt is an MFS efflux pump that confers resistance to multiple drugs such as rhodamine and acridine dyes, and fluoroquinolone antibiotics.", "model_sequences": {"$update": {"sequence": {"$update": {"710": {"$update": {"dna_sequence": {"$update": {"accession": "L32599.1"}}}}}}}}, "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "blt"}}, "2691": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Type_A_NfxB"}}, "4650": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7025": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-37"}}, "2405": {"$update": {"ARO_description": "Point mutations in Neisseria gonorrhoeae parC protein that confer resistance to fluoroquinolone by reducing affinity to antibiotic binding site.", "model_name": "Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Ngon_parC_FLO"}}, "4653": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-40"}}, "1973": {"$update": {"ARO_description": "TEM-111 is a beta-lactamase found in E. coli and P. mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1643": {"$update": {"dna_sequence": {"$update": {"accession": "AF468003.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-111"}}, "4800": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7175": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ORN-6"}}, "4652": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-39"}}, "1661": {"$update": {"ARO_description": "CARB-8 is a beta-lactamase found in Oligella urethralis.", "model_sequences": {"$update": {"sequence": {"$update": {"1894": {"$update": {"dna_sequence": {"$update": {"accession": "AY178993.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-8"}}, "1972": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1754": {"$update": {"dna_sequence": {"$update": {"accession": "GQ853680.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-149"}}, "1971": {"$update": {"ARO_description": "dfrB2 is an integron-encoded dihydrofolate reductase found in an uncultured bacterium from a wastewater treatment plant."}, "$insert": {"CARD_short_name": "dfrB2"}}, "1748": {"$update": {"ARO_description": "LsaC is an ABC-F subfamily protein expressed in Streptococcus agalactiae. It confers resistance to lincomycin, clindamycin, dalfopristin, and tiamulin.", "model_sequences": {"$update": {"sequence": {"$update": {"76": {"$update": {"dna_sequence": {"$update": {"accession": "HM990671.1"}}}}}}}}}, "$insert": {"CARD_short_name": "lsaC"}}, "1970": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2025": {"$update": {"dna_sequence": {"$update": {"accession": "AY259119.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-44"}}, "1968": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2125": {"$update": {"dna_sequence": {"$update": {"accession": "KP050494.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-189"}}, "1969": {"$insert": {"CARD_short_name": "tet(35)"}}, "1618": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"809": {"$update": {"dna_sequence": {"$update": {"accession": "KF460532.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-362"}}, "1619": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1909": {"$update": {"dna_sequence": {"$update": {"accession": "AJ272109.1"}}}}}}}}}, "$insert": {"CARD_short_name": "L1_BLA"}}, "1616": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1589": {"$update": {"dna_sequence": {"$update": {"accession": "KJ461948.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-152"}}, "1617": {"$update": {"ARO_description": "VanE is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.", "model_sequences": {"$update": {"sequence": {"$update": {"216": {"$update": {"dna_sequence": {"$update": {"accession": "FJ872411.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanE"}}, "1614": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1325": {"$update": {"dna_sequence": {"$update": {"accession": "JN935136.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-194"}}, "1615": {"$update": {"ARO_description": "APH(2'')-IIa is a chromosomal-encoded aminoglycoside phosphotransferase in E. faecium and E. coli.", "model_sequences": {"$update": {"sequence": {"$update": {"696": {"$update": {"dna_sequence": {"$update": {"accession": "AF337947.1"}}}}}}}}, "ARO_category": {"$update": {"36267": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''."}}}}}, "$insert": {"CARD_short_name": "APH(2'')-IIa"}}, "1960": {"$update": {"ARO_description": "smeB is the inner membrane multidrug exporter of the efflux complex smeABC in Stenotrophomonas maltophilia.", "model_sequences": {"$update": {"sequence": {"$update": {"521": {"$update": {"dna_sequence": {"$update": {"accession": "AF173226.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "smeB"}}, "1613": {"$update": {"ARO_description": "CMY-38 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1021": {"$update": {"dna_sequence": {"$update": {"accession": "AM931008.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-38"}}, "1610": {"$update": {"ARO_description": "OXA-74 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1305": {"$update": {"dna_sequence": {"$update": {"accession": "AJ854182.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-74"}}, "1611": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1565": {"$update": {"dna_sequence": {"$update": {"accession": "KF481967.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SME-4"}}, "4845": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-510"}}, "1966": {"$insert": {"CARD_short_name": "lmrA"}}, "1749": {"$update": {"ARO_description": "IMP-18 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"912": {"$update": {"dna_sequence": {"$update": {"accession": "JN596991.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-18"}}, "2873": {"$update": {"ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catV"}}, "2872": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-93"}}, "2871": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-92"}}, "2870": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-91"}}, "2877": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-535"}}, "2876": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-436"}}, "2875": {"$insert": {"CARD_short_name": "sul4"}}, "2874": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACI-1"}}, "2878": {"$insert": {"CARD_short_name": "almG"}}, "3217": {"$update": {"ARO_description": "A chromosomal macrolide phosphotransferase identified from Bacillus subtilis."}, "$insert": {"CARD_short_name": "mphK"}}, "3355": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5535": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Ecol_catII"}}, "3357": {"$update": {"ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catA4"}}, "3356": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-296"}}, "3351": {"$insert": {"CARD_short_name": "Erm(O)-lrm"}}, "3353": {"$insert": {"CARD_short_name": "Cdif_23S_MULT"}}, "3359": {"$update": {"ARO_description": "NBU2-encoded resistance gene. An MefE homolog in Bacteroides species. Macrolide efflux MFS transporter."}, "$insert": {"CARD_short_name": "Mef(En2)"}}, "3358": {"$update": {"ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catA8"}}, "5492": {"$insert": {"CARD_short_name": "PDC-362"}}, "5449": {"$insert": {"CARD_short_name": "PDC-319"}}, "5448": {"$insert": {"CARD_short_name": "PDC-318"}}, "5443": {"$insert": {"CARD_short_name": "PDC-312"}}, "5442": {"$insert": {"CARD_short_name": "PDC-311"}}, "5441": {"$insert": {"CARD_short_name": "PDC-310"}}, "5440": {"$insert": {"CARD_short_name": "PDC-31"}}, "5447": {"$insert": {"CARD_short_name": "PDC-317"}}, "5446": {"$insert": {"CARD_short_name": "PDC-316"}}, "5445": {"$insert": {"CARD_short_name": "PDC-315"}}, "5444": {"$insert": {"CARD_short_name": "PDC-314"}}, "1768": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1185": {"$update": {"dna_sequence": {"$update": {"accession": "KJ020573.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-144"}}, "1769": {"$update": {"ARO_description": "CTX-M-115 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"766": {"$update": {"dna_sequence": {"$update": {"accession": "KJ911020.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-115"}}, "1762": {"$update": {"ARO_description": "aadA16 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in E. coli, V. cholerae and K. pneumoniae.", "model_sequences": {"$update": {"sequence": {"8226": {"dna_sequence": {"partial": "0", "sequence": "ATGAGCAACGCAGTGCCCGCCGAGATTTCGGTACAGCTATCACAGGCACTCAACGTCATCGAGCGTCATCTGGGATCGACGTTGCTGGCCGTGCATTTGTACGGCTCTGCACTCGACGGTGGCCTGAAGCCATGCAGTGATATTGATTTGCTGGTTACTGTGACTGCACAGCTCGATGAGACTGTGCGGCAGGCTCTGTTCGTAGATTTCCTGGAAGTTTCCGCTTCTCCCGGCCAAAGTGAAGCTCTCCGTGCCTTGGAAGTTACCATCGTCGTGTACGGCGATGTTGCTCCTTGGCGTTATCTAGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGCAAGGACATTCTTGCGGGCATCTTCGAGCCCGCGACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGCAAGGCAACACAGCCTTGCCTTGGCAGGTTCGGCCGCGGAAGATTTCTTCAACTCAGTCCCGGAAAGCGATCTATTCAAAGCACTGGCCGACACCTTGAAACTATGGAACTCACAACCGGATTGGGCAGGCGACGAGCGGAATGTAGTGCTTACTTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCGCCGAAGGATGTAGCTGCCAACTGGGTAATGGAACGCCTGCCCGTCCAACATCAGCCCGTGCTGCTTGAAGCCCAGCAGGCTTACCTTGGACAAGGGATGGATTGCTTGGCCTCACGCGCTGATCAGTTGACTGCGTTCATTTACTTTGTGAAGCACGAAGCCGCCAGTCTGCTCGGCTCCACGCCAATGATGTCTAACAGTTCATTCAAGCCGACGCCGCTTCGCGGCGCAGCTTAA", "fmax": "4042", "accession": "EU675686.2", "fmin": "3196", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ACF17980.1", "sequence": "MSNAVPAEISVQLSQALNVIERHLGSTLLAVHLYGSALDGGLKPCSDIDLLVTVTAQLDETVRQALFVDFLEVSASPGQSEALRALEVTIVVYGDVAPWRYLARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKARQHSLALAGSAAEDFFNSVPESDLFKALADTLKLWNSQPDWAGDERNVVLTLSRIWYSAATGKIAPKDVAANWVMERLPVQHQPVLLEAQQAYLGQGMDCLASRADQLTAFIYFVKHEAASLLGSTPMMSNSSFKPTPLRGAA"}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA16"}}, "1763": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"777": {"$update": {"dna_sequence": {"$update": {"accession": "JF703135.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-2"}}, "1760": {"$update": {"ARO_description": "QnrB35 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"555": {"$update": {"dna_sequence": {"$update": {"accession": "JN173057.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB35"}}, "1761": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1133": {"$update": {"dna_sequence": {"$update": {"accession": "KF297580.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-351"}}, "1766": {"$update": {"ARO_description": "VIM-14 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1082": {"$update": {"dna_sequence": {"$update": {"accession": "AY635904.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-14"}}, "1767": {"$update": {"ARO_description": "OKP-A-16 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1287": {"$update": {"dna_sequence": {"$update": {"accession": "FJ755840.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-16"}}, "1764": {"$update": {"ARO_description": "OXA-97 is a beta-lactamase found in A. baumannii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-97"}}, "1765": {"$update": {"ARO_description": "OXA-56 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1056": {"$update": {"dna_sequence": {"$update": {"accession": "AY445080.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-56"}}, "1142": {"$update": {"ARO_description": "dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"291": {"$update": {"dna_sequence": {"$update": {"accession": "DQ838665.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA17"}}, "1143": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"894": {"$update": {"dna_sequence": {"$update": {"accession": "X75562.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-7"}}, "1140": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1197": {"$update": {"dna_sequence": {"$update": {"accession": "KJ207204.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-86"}}, "1141": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1525": {"$update": {"dna_sequence": {"$update": {"accession": "HM488990.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-169"}}, "1146": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1400": {"$update": {"dna_sequence": {"$update": {"accession": "AM941159.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-156"}}, "1147": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1859": {"$update": {"dna_sequence": {"$update": {"accession": "HQ650104.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-63"}}, "1144": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4415": {"$update": {"dna_sequence": {"$update": {"accession": "AF015628.1"}}}}}}}}, "model_name": "vgbB", "ARO_category": {"$update": {"37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "vgbB"}}, "1145": {"$update": {"ARO_description": "CTX-M-124 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1333": {"$update": {"dna_sequence": {"$update": {"accession": "JQ429324.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-124"}}, "1148": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"890": {"$update": {"dna_sequence": {"$update": {"accession": "KF460533.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-363"}}, "1149": {"$update": {"ARO_description": "AER-1 is a beta-lactamase found in Aeromonas hydrophila.", "model_sequences": {"$update": {"sequence": {"$update": {"901": {"$update": {"dna_sequence": {"$update": {"accession": "U14748.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "AER-1"}}, "5508": {"$insert": {"CARD_short_name": "PDC-378"}}, "5509": {"$insert": {"CARD_short_name": "PDC-379"}}, "5506": {"$insert": {"CARD_short_name": "PDC-375"}}, "5507": {"$insert": {"CARD_short_name": "PDC-377"}}, "5504": {"$insert": {"CARD_short_name": "PDC-373"}}, "5505": {"$insert": {"CARD_short_name": "PDC-374"}}, "5502": {"$insert": {"CARD_short_name": "PDC-371"}}, "5503": {"$insert": {"CARD_short_name": "PDC-372"}}, "5500": {"$insert": {"CARD_short_name": "PDC-37"}}, "5501": {"$insert": {"CARD_short_name": "PDC-370"}}, "692": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1646": {"$update": {"dna_sequence": {"$update": {"accession": "EF136376.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-159"}}, "693": {"$update": {"ARO_description": "OXA-22 is a beta-lactamase found in Ralstonia pickettii.", "model_sequences": {"$update": {"sequence": {"8222": {"dna_sequence": {"partial": "0", "sequence": "ATGAAACGCCGCCACGCCGCCATCGGCGCCCTGCTTGCCGCGCTTGCCACCTTTGCCCACGCCGAGCACCCGATCTGCACGATCGTGGCCGATGCCGCCACGGGCAAGGCCGTCTTGCATGAAGGCAAGTGCGACGAGCGCGTGACGCCCGCTTCCACCTTCAAGCTGGCGCTGGCCGTCATGGGCTTCGACCACGGCTTCCTCAAAGATGAGCACACCCCGGTTGAGCACTTCAGGCACGGTGACCCCGACTGGGGCGGCGAAGCCTGGCACCAGCCGATCGACCCGGCGCTGTGGCTCAAGTATTCGGTGGTCTGGTATTCGCAGCGCATTACGCATGCGATGGGCGCGCAGACCTTCCAGGCCTACGTGCGCAAGCTTGGCTACGGCAACATGGATGTGAGCGGCGATCCGGGCAAGAACAACGGCATGGACCGCTCGTGGATCACCTCGTCGCTGAAGATTTCGCCGGAAGAGCAAGTCGGCTTGATGCGCCGGATCGTCAACCGGCAGTTGCCGGTGTCGGCGCACACCTACGAGATGCTCGACCGTACCGTGCAGACCTGGCAGGTGCCCGGCGGCTGGGCGGTGCAGGGCAAGACGGGCACTGCCGGTCCGGCGCCGGGCAACACGTCGCCCGATGGCACGTGGGATCAGGCACACGCTTACGGCTGGTTTGTCGGCTGGGCCAGGAAGGGCGACAAGACCTACGTATTCGCCAACCTGATCCAGGACGACAAGGTTGAGCCGACGTCGGGCGGTATCCGCTCGCGCGATGCGCTGTTTGCTCGCCTGTCGGAAGTGCTGGCCTTTGCTGGGCACTGA", "fmax": "1776", "accession": "AF064820.3", "fmin": "951", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Ralstonia pickettii", "NCBI_taxonomy_id": "329", "NCBI_taxonomy_cvterm_id": "36921"}, "protein_sequence": {"accession": "AAD12233.1", "sequence": "MKRRHAAIGALLAALATFAHAEHPICTIVADAATGKAVLHEGKCDERVTPASTFKLALAVMGFDHGFLKDEHTPVEHFRHGDPDWGGEAWHQPIDPALWLKYSVVWYSQRITHAMGAQTFQAYVRKLGYGNMDVSGDPGKNNGMDRSWITSSLKISPEEQVGLMRRIVNRQLPVSAHTYEMLDRTVQTWQVPGGWAVQGKTGTAGPAPGNTSPDGTWDQAHAYGWFVGWARKGDKTYVFANLIQDDKVEPTSGGIRSRDALFARLSEVLAFAGH"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-22"}}, "1544": {"$update": {"ARO_description": "dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis."}, "$insert": {"CARD_short_name": "dfrE"}}, "691": {"$update": {"ARO_description": "Also known as vanRE, is a vanR variant found in the vanE gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"167": {"$update": {"dna_sequence": {"$update": {"accession": "FJ872411.1"}}}}}}}}, "model_name": "vanR gene in vanE cluster", "ARO_name": "vanR gene in vanE cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanE_cl"}}, "696": {"$update": {"ARO_description": "CfrA is a chloramphenicol-florfenicol resistance gene and methyltransferase enzyme. Methylation of position 8 of A2503 in 23S rRNA confers resistance to chloramphenicol antibiotics first identified by Schwarz 2000 as cfr from Mammaliicoccus sciuri. Additional Oxazolidinone resistance mediated by the cfr gene in a human isolated was first reported from Colombia in linezolid- and methicillin-resistant Staphylococcus aureus.", "model_sequences": {"$update": {"sequence": {"$update": {"4584": {"$update": {"dna_sequence": {"$update": {"accession": "AM408573.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "cfrA"}}, "697": {"$update": {"ARO_description": "Erm42 confers MLSb phenotype in Pasteurella multocida.", "model_sequences": {"$update": {"sequence": {"$update": {"11": {"$update": {"dna_sequence": {"$update": {"accession": "FR734406.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Erm(42)"}}, "694": {"$update": {"ARO_description": "CTX-M-40 is a beta-lactamase found in Escherichia coli."}, "$insert": {"CARD_short_name": "CTX-M-40"}}, "695": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"783": {"$update": {"dna_sequence": {"$update": {"accession": "JN714478.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-66"}}, "5510": {"$insert": {"CARD_short_name": "PDC-38"}}, "698": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1957": {"$update": {"dna_sequence": {"$update": {"accession": "KC900516.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-205"}}, "699": {"$update": {"ARO_description": "QnrS9 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"632": {"$update": {"dna_sequence": {"$update": {"accession": "KF732714.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS9"}}, "1548": {"$update": {"ARO_description": "APH(3')-Vb is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces ribosidificus.", "model_sequences": {"$update": {"sequence": {"$update": {"407": {"$update": {"dna_sequence": {"$update": {"accession": "M22126.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-Vb"}}, "1549": {"$update": {"model_sequences": {"$update": {"sequence": {"8354": {"dna_sequence": {"partial": "0", "sequence": "ATGAACAAAAATATAAAATATTCTCAAAACTTTTTAACGAGTGAAAAAGTACTCAACCAAATAATAAAACAATTGAATTTAAAAGAAACCGATACCGTTTACGAAATTGGAACAGGTAAAGGGCATTTAACGACGAAACTGGCTAAAATAAGTAAACAGGTAACGTCTATTGAATTAGACAGTCATCTATTCAACTTATCGTCAGAAAAATTAAAACTGAATACTCGTGTCACTTTAATTCACCAAGATATTCTACAGTTTCAATTCCCTAACAAACAGAGGTATAAAATTGTTGGGAGTATTCCTTACAATTTAAGCACACAAATTATTAAAAAAGTGGTTTTTGAAAGCCGTGCGTCTGACATCTATCTGATTGTTGAAGAAGGATTCTACAAGCGTACCTTGGATATTCACCGAACACTAGGGTTGCTCTTGCACACTCAAGTCTCGATTCAGCAATTGCTTAAGCTGCCAGCGGAATGCTTTCATCCTAAACCAAAAGTAAACAGTGTCTTAATAAAACTTACCCGCCATACCACAGATGTTCCAGATAAATATTGGAAGCTATATACGTACTTTGTTTCAAAATGGGTCAATCGAGAATATCGTCAACTGTTTACTAAAAATCAGTTTCATCAAGCAATGAAACACGCCAAAGTAAACAATTTAAGTACCATTACTTATGAGCAAGTATTGTCTATTTTTAATAGTTATCTATTATTTAACGGGAGGAAATTAATTCTATGA", "fmax": "2878", "accession": "AF242872.1", "fmin": "2131", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"accession": "AAF86219.1", "sequence": "MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFPNKQRYKIVGSIPYNLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRKLIL"}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmB"}}, "542": {"$insert": {"CARD_short_name": "adeH"}}, "543": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1153": {"$update": {"dna_sequence": {"$update": {"accession": "AY101578.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-106"}}, "540": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"65": {"$update": {"dna_sequence": {"$update": {"accession": "D78168.1"}}}}}}}}}, "$insert": {"CARD_short_name": "emrY"}}, "541": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"844": {"$update": {"dna_sequence": {"$update": {"accession": "AY528425.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-133"}}, "546": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3315": {"$update": {"dna_sequence": {"$update": {"accession": "AF148067.1"}}}}}}}}}, "$insert": {"CARD_short_name": "TLA-1"}}, "547": {"$update": {"ARO_description": "arr-5 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"567": {"$update": {"dna_sequence": {"$update": {"accession": "EF660563.1"}}}}}}}}}, "$insert": {"CARD_short_name": "arr-5"}}, "544": {"$update": {"ARO_description": "AAC(6')-Is is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter variabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"669": {"$update": {"dna_sequence": {"$update": {"accession": "AF031327.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Is"}}, "545": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1415": {"$update": {"dna_sequence": {"$update": {"accession": "JX023441.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-22"}}, "3784": {"$insert": {"CARD_short_name": "mlaF"}}, "548": {"$update": {"ARO_description": "QnrB3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"277": {"$update": {"dna_sequence": {"$update": {"accession": "DQ303920.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB3"}}, "549": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1240": {"$update": {"dna_sequence": {"$update": {"accession": "AY101764.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-107"}}, "1782": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"996": {"$update": {"dna_sequence": {"$update": {"accession": "M88143.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-12"}}, "3885": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-812"}}, "1783": {"$update": {"ARO_description": "VIM-36 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1578": {"$update": {"dna_sequence": {"$update": {"accession": "JX982635.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-36"}}, "4938": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-612"}}, "1784": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1687": {"$update": {"dna_sequence": {"$update": {"accession": "KF203108.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-334"}}, "1982": {"$update": {"ARO_description": "IMP-9 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"8223": {"dna_sequence": {"partial": "0", "sequence": "ATGAGCAAGTTATTTGTATTCTTTATGTTTTTGTTTTGTAGCATTACTGCCGCAGGAGAGTCTTTGCCAGATTTAAAAATTGAGAAGCTTGACGAAGGCGTTTATGTTCATACTTCGTTTGAAGAAGTTAACGGTTGGGGTGTTATTCCTAAACACGGCTTGGTGGTTCTTGTAAATACTGATGCCTATCTGATAGACACTCCATTTACTGCTAAAGATACTGAAAATTTAGTTAATTGGTTTGTTGAGCGCGGCTATAGAATAAAAGGCAGTATTTCCTCACATTTCCATAGCGACAGCACGGGTGGAATAGAGTGGCTTAATTCTCAATCTATCCCCACGTATGCATCTGAATTAACAAATGAACTTCTTAAAAAAGACGGTAAGGTACAAGCTAAATATTCATTTAGCGGAGTTAGCTATTGGCTAGTTAAGAAAAAGATTGAAGTTTTTTATCCTGGTCCAGGGCACGCTCCAGATAACGTAGTGGTTTGGCTGCCTGAAAATAGAGTTTTGTTCGGTGGTTGTTTTGTTAAACCCTACGGTCTAGGTAATTTGGGTGACGCAAATTTAGAAGCTTGGCCAAAATCCGCCAAATTATTAATGTCAAAATATAGTAAGGCAAAACTGGTTGTACCAAGTCATAGTGACATAGGAGATTCGTCGCTCTTGAAGCTTACATGGGAGCAGACGGTAAAAGGATTCAATGAAAGCAAAAAAAGTACCACTGCACATTAA", "fmax": "457877", "accession": "KC543497.1", "fmin": "457139", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AAK59385.1", "sequence": "MSKLFVFFMFLFCSITAAGESLPDLKIEKLDEGVYVHTSFEEVNGWGVIPKHGLVVLVNTDAYLIDTPFTAKDTENLVNWFVERGYRIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKYSFSGVSYWLVKKKIEVFYPGPGHAPDNVVVWLPENRVLFGGCFVKPYGLGNLGDANLEAWPKSAKLLMSKYSKAKLVVPSHSDIGDSSLLKLTWEQTVKGFNESKKSTTAH"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-9"}}, "1785": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1650": {"$update": {"dna_sequence": {"$update": {"accession": "Y10280.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-48"}}, "1786": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"414": {"$update": {"dna_sequence": {"$update": {"accession": "AB015853.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mexY"}}, "957": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"239": {"$update": {"dna_sequence": {"$update": {"accession": "AF133139.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(G)"}}, "1787": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2128": {"$update": {"dna_sequence": {"$update": {"accession": "KP071470.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-42"}}, "3880": {"$insert": {"CARD_short_name": "PDC-23"}}, "5476": {"$insert": {"CARD_short_name": "PDC-347"}}, "5618": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-15"}}, "5619": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-16"}}, "5719": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-70"}}, "5477": {"$insert": {"CARD_short_name": "PDC-348"}}, "5612": {"$insert": {"CARD_short_name": "PDC-99"}}, "5613": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-10"}}, "5610": {"$insert": {"CARD_short_name": "PDC-97"}}, "5611": {"$insert": {"CARD_short_name": "PDC-98"}}, "5616": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-13"}}, "5617": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7992": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-14"}}, "5614": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7989": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-11"}}, "5615": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-12"}}, "414": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1612": {"$update": {"dna_sequence": {"$update": {"accession": "KF986258.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-377"}}, "415": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4506": {"$update": {"dna_sequence": {"$update": {"accession": "GU371926.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-33"}}, "416": {"$update": {"ARO_description": "OXA-204 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1605": {"$update": {"dna_sequence": {"$update": {"accession": "JQ809466.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-204"}}, "417": {"$update": {"ARO_description": "QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans.", "model_sequences": {"$update": {"sequence": {"$update": {"610": {"$update": {"dna_sequence": {"$update": {"accession": "EF520349.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB6"}}, "1388": {"$update": {"ARO_description": "oleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion.", "model_sequences": {"$update": {"sequence": {"$update": {"3347": {"$update": {"dna_sequence": {"$update": {"accession": "L36601.1"}}}}}}}}}, "$insert": {"CARD_short_name": "oleB"}}, "411": {"$update": {"ARO_description": "QnrB11 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"146": {"$update": {"dna_sequence": {"$update": {"accession": "EF653270.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB11"}}, "412": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-117"}}, "413": {"$update": {"ARO_description": "OXA-144 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1369": {"$update": {"dna_sequence": {"$update": {"accession": "FJ872530.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-144"}}, "1384": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2011": {"$update": {"dna_sequence": {"$update": {"accession": "KJ135345.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-382"}}, "1385": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mdsB"}}, "1386": {"$update": {"ARO_description": "ANT(9)-Ia is an aminoglycoside nucleotidyltransferase encoded by plasmids and transposons in S. aureus, Enterococcus spp., Mammaliicoccus sciuri, and E. faecalis.", "ARO_category": {"$update": {"36367": {"$update": {"category_aro_description": "Nucleotidylylation of spectinomycin at the hydroxyl group at position 9."}}}}}, "$insert": {"CARD_short_name": "ANT(9)-Ia"}}, "1387": {"$update": {"ARO_description": "OXA-99 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1847": {"$update": {"dna_sequence": {"$update": {"accession": "DQ888718.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-99"}}, "1380": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1245": {"$update": {"dna_sequence": {"$update": {"accession": "JN935135.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-193"}}, "419": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3312": {"$update": {"dna_sequence": {"$update": {"accession": "AY590118.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SLB-1"}}, "1382": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"93": {"$update": {"dna_sequence": {"$update": {"accession": "JX486113.1"}}}}}}}}}, "$insert": {"CARD_short_name": "rmtG"}}, "1383": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1435": {"$update": {"dna_sequence": {"$update": {"accession": "KF958750.1"}}}}}}}}}, "$insert": {"CARD_short_name": "IMI-4"}}, "3827": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-898"}}, "3826": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-899"}}, "3825": {"$insert": {"CARD_short_name": "RanA"}}, "3824": {"$insert": {"CARD_short_name": "RanB"}}, "3823": {"$insert": {"CARD_short_name": "mef(D)"}}, "3822": {"$insert": {"CARD_short_name": "msrH"}}, "3821": {"$insert": {"CARD_short_name": "msrF"}}, "3820": {"$insert": {"CARD_short_name": "AAC(3)-IIg"}}, "5098": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-793"}}, "3327": {"$update": {"ARO_description": "AAC(2')-IIa is a kasugamycin 2' N-acetyltransferase protein found in Burkholderia glumae and Acidovorax avenae isolates."}, "$insert": {"CARD_short_name": "AAC(2')-IIa"}}, "3582": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ERP-1"}}, "3829": {"$update": {"ARO_description": "A blaZ-like beta-lactamase found in S. Aureus.", "model_sequences": {"$update": {"sequence": {"8358": {"dna_sequence": {"partial": "0", "sequence": "TTGAAAAAATTAATAATTTTAGTCGTGTTAGCGTTGATATTAAGTGCTTGTAATAGTAAGAATTCAACTAATAACGACATTGAAAAGATCGAAAAAAAATATGGTGCTAACGTAGGTATGTATGCTCTTAATACTCAAAATGGTAAAGAATTATCATTTAATGAAAATAAGCGTTTTGCATATGCTTCCACATTAAAAACTATAAGTAGCGCAATGCTGCTTGAACAAACACCTTACAACAAATTAGATAAAAAAATTCACATTAATAAAGATGATATTGTTCCATATTCACCAGTGTTAGAAAAATATATTGGCAAAGAGATAACTTTAAAAAAGCTTATAGAAGCTACCATGTTATTTAGCGATAACACGGCTAATAATAAAATTATCGATGAATTGGGAGGATATGGGCAAGTAAAAACGAAACTGATAGATTTAGGCGATACAACGACACATCCATCTAGAAAAGAACCAGACTTAAATTTTTATTCACCAAAGGATAAACGAGATACAAGTACTCCATTAGCCTATGGTAAAACTTTAAAGAAACTTATAGCTGATGGAGATCTTAGCAAAGCAAACAAAGATTTCTTACTTAATCTAATGTTCAAAAATAAAAGTGGCGATACATTAATTAAGGATGGTGCACCTTCAAACTTTAAAGTTATGGATAAGAGCGGTCAAGCACTAACATACGGTTCAAGAAACGATGTTGCGTTTGTTTATCCAGATGGACAAGATAAACCTATAATTCTGGTGATATTTACAAATAAAGATAGAAAAGATGGTAAACCTAATGACAAAATAGTAAGTGAGGTTGCTGAAATTGTACTAAAAAATATTAATGAGTAA", "fmax": "1647", "accession": "FR823292.1", "fmin": "795", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"accession": "CBZ41939.1", "sequence": "MKKLIILVVLALILSACNSKNSTNNDIEKIEKKYGANVGMYALNTQNGKELSFNENKRFAYASTLKTISSAMLLEQTPYNKLDKKIHINKDDIVPYSPVLEKYIGKEITLKKLIEATMLFSDNTANNKIIDELGGYGQVKTKLIDLGDTTTHPSRKEPDLNFYSPKDKRDTSTPLAYGKTLKKLIADGDLSKANKDFLLNLMFKNKSGDTLIKDGAPSNFKVMDKSGQALTYGSRNDVAFVYPDGQDKPIILVIFTNKDRKDGKPNDKIVSEVAEIVLKNINE"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "41361": {"$update": {"category_aro_name": "BlaZ beta-lactamase", "category_aro_description": "BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus."}}}}}, "$insert": {"CARD_short_name": "mecC-type_BlaZ"}}, "3828": {"$insert": {"CARD_short_name": "GPC-1"}}, "3618": {"$update": {"ARO_description": "From Lahey's list of beta-lactamases, no additional information available.", "model_sequences": {"$update": {"sequence": {"$update": {"5816": {"$update": {"dna_sequence": {"$update": {"accession": "KP681694.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-49"}}, "2768": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MdtEF-TolC"}}, "5007": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-695"}}, "3585": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FONA-1"}}, "4282": {"$insert": {"CARD_short_name": "ADC-217"}}, "4283": {"$insert": {"CARD_short_name": "ADC-218"}}, "4280": {"$insert": {"CARD_short_name": "ADC-215"}}, "4281": {"$insert": {"CARD_short_name": "ADC-216"}}, "4286": {"$insert": {"CARD_short_name": "ADC-221"}}, "4287": {"$insert": {"CARD_short_name": "ADC-222"}}, "4284": {"$insert": {"CARD_short_name": "ADC-219"}}, "4285": {"$insert": {"CARD_short_name": "ADC-220"}}, "4288": {"$insert": {"CARD_short_name": "ADC-223"}}, "4289": {"$insert": {"CARD_short_name": "ADC-224"}}, "2406": {"$insert": {"CARD_short_name": "rpsJ"}}, "2763": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "MdtABC-TolC"}}, "368": {"$update": {"ARO_description": "CARB-14 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1991": {"$update": {"dna_sequence": {"$update": {"accession": "JQ364968.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-14"}}, "369": {"$update": {"model_sequences": {"$update": {"sequence": {"8259": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAATGCTGGCGCGGGTGGATGCCGGTGACAAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTAGCAAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AJ011428.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "CAB37325.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAMLARVDAGDKQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-15"}}, "366": {"$update": {"ARO_description": "Specific mutations in Mycobacterium tuberculosis iniA resulting in resistance to ethambutol.", "model_sequences": {"$update": {"sequence": {"$update": {"2099": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}, "ARO_category": {"$update": {"40040": {"$update": {"category_aro_description": "Mutations that occurs on the iniA genes resulting in the resistance to ethambutol."}}}}, "model_name": "Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol", "ARO_name": "Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol"}, "$insert": {"CARD_short_name": "Mtub_iniA_EMB"}}, "367": {"$update": {"ARO_description": "CTX-M-25 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8221": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAGAAAAAGCGTAAGGCGGGCGATGTTAATGACGACAGCCTGTGTTTCGCTGCTGTTGGCCAGTGTGCCGCTGTGTGCCCAGGCGAACGATGTTCAACAAAAGCTCGCGGCGCTGGAGAAAAGCAGCGGGGGACGACTGGGTGTGGCGTTGATTAACACCGCCGATAACACGCAGACGCTCTACCGCGCCGACGAGCGTTTTGCCATGTGCAGCACCAGTAAAGTGATGGCGGTAGCGGCGGTGCTTAAGCAAAGTGAAACGCAAAAGGGCTTGTTGAGTCAGCGGGTTGAAATTAAGCCCTCAGACTTGATTAACTACAACCCCATTGCGGAAAAACACGTCAATGGCACGATGACATTCGGGGAGTTGAGCGCGGCGGCGCTACAGTACAGCGATAATACTGCCATGAATAAGCTGATTGCCCATCTCGGGGGGCCGGATAAAGTGACGGCATTTGCCCGTACGATTGGCGATGACACGTTCCGGCTCGATCGTACCGAGCCGACGCTCAACACCGCGATCCCCGGCGACCCGCGCGATACCACCACGCCGTTAGCGATGGCGCAGGCTCTGCGCAATCTGACGTTGGGCAATGCCCTGGGTGACACTCAGCGTGCGCAGCTGGTGATGTGGCTGAAAGGCAACACCACCGGCGCTGCCAGCATTCAGGCAGGGCTACCCACATCGTGGGTTGTCGGGGATAAAACCGGCAGCGGCGGTTATGGTACGACGAATGATATCGCGGTTATTTGGCCGGAAGGTCGCGCGCCGCTCGTTCTGGTGACTTACTTCACCCAGTCGGAGCCGAAGGCAGAGAGCCGTCGTGACGTGCTCGCTGCTGCCGCCAGAATTGTCACCGACGGTTATTAA", "fmax": "3196", "accession": "AF518567.2", "fmin": "2320", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAM70498.1", "sequence": "MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEIKPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-25"}}, "364": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"959": {"$update": {"dna_sequence": {"$update": {"accession": "JX440351.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-83"}}, "365": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1241": {"$update": {"dna_sequence": {"$update": {"accession": "AY307100.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-122"}}, "362": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1511": {"$update": {"dna_sequence": {"$update": {"accession": "AB916359.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-151"}}, "363": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1323": {"$update": {"dna_sequence": {"$update": {"accession": "DQ679961.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-155"}}, "360": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"397": {"$update": {"dna_sequence": {"$update": {"accession": "AF144880.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iy"}}, "361": {"$update": {"ARO_description": "OXA-278 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"806": {"$update": {"dna_sequence": {"$update": {"accession": "KC771279.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-278"}}, "5274": {"$insert": {"CARD_short_name": "PDC-137"}}, "2760": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "MexGHI-OpmD"}}, "5275": {"$insert": {"CARD_short_name": "PDC-138"}}, "5637": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8012": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "RAHN-2"}}, "5276": {"$insert": {"CARD_short_name": "PDC-139"}}, "380": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1272": {"$update": {"dna_sequence": {"$update": {"accession": "KF513180.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-147"}}, "381": {"$update": {"ARO_description": "QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri.", "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS1"}}, "382": {"$update": {"ARO_description": "QnrB61 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii.", "model_sequences": {"$update": {"sequence": {"$update": {"721": {"$update": {"dna_sequence": {"$update": {"accession": "AB734053.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB61"}}, "383": {"$update": {"ARO_description": "Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin."}, "$insert": {"CARD_short_name": "Paer_PhoQ_CST"}}, "384": {"$update": {"ARO_description": "APH(2'')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in E. casseliflavus.", "model_sequences": {"$update": {"sequence": {"$update": {"729": {"$update": {"dna_sequence": {"$update": {"accession": "AF016483.1"}}}}}}}}, "ARO_category": {"$update": {"36267": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''."}}}}}, "$insert": {"CARD_short_name": "APH(2'')-IVa"}}, "385": {"$update": {"ARO_description": "OXA-46 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1536": {"$update": {"dna_sequence": {"$update": {"accession": "JX131372.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-46"}}, "386": {"$update": {"ARO_description": "LEN-8 is a beta-lactamase found in Klebsiella pneumoniae.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-8"}}, "387": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"15": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}}, "$insert": {"CARD_short_name": "mdtA"}}, "388": {"$update": {"ARO_description": "QnrB71 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii.", "model_sequences": {"$update": {"sequence": {"$update": {"406": {"$update": {"dna_sequence": {"$update": {"accession": "KC580660.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB71"}}, "389": {"$insert": {"CARD_short_name": "tetW"}}, "5271": {"$insert": {"CARD_short_name": "PDC-134"}}, "4758": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7133": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "LUT-5"}}, "4759": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7134": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "LUT-6"}}, "5272": {"$insert": {"CARD_short_name": "PDC-135"}}, "4750": {"$insert": {"CARD_short_name": "LHK-5"}}, "4751": {"$insert": {"CARD_short_name": "LHK-6"}}, "4752": {"$insert": {"CARD_short_name": "LRG-1"}}, "4753": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7128": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "LUS-1"}}, "4754": {"$insert": {"CARD_short_name": "LUT-1"}}, "4755": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7130": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "LUT-2"}}, "4756": {"$insert": {"CARD_short_name": "LUT-3"}}, "4757": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7132": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "LUT-4"}}, "5375": {"$insert": {"CARD_short_name": "PDC-237"}}, "5374": {"$insert": {"CARD_short_name": "PDC-236"}}, "3216": {"$update": {"ARO_description": "A chromosomal macrolide 2'-phosphotransferase and resistance gene identified from a Brachybacterium faecium cave isolate."}, "$insert": {"CARD_short_name": "mphH"}}, "5377": {"$insert": {"CARD_short_name": "PDC-239"}}, "3759": {"$update": {"ARO_description": "APH(3')-VIb is a plasmid-encoded aminoglycoside phosphotransferase in K. pneumoniae and S. marcescens.", "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-VIb"}}, "3758": {"$insert": {"CARD_short_name": "VMB-1"}}, "5376": {"$insert": {"CARD_short_name": "PDC-238"}}, "4664": {"$insert": {"CARD_short_name": "GRD23-1"}}, "3751": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6042": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-181"}}, "3750": {"$update": {"ARO_description": "A tetracycline efflux MFS Transporter from Providencia sp. Y14."}, "$insert": {"CARD_short_name": "tet(57)"}}, "3753": {"$update": {"model_name": "TxR"}, "$insert": {"CARD_short_name": "TxR"}}, "3755": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "qacEdelta1"}}, "3754": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}}, "$insert": {"CARD_short_name": "qacE"}}, "3757": {"$update": {"ARO_description": "IDC-2 is an IDC beta-lactamase and an integron cephalosprinase."}, "$insert": {"CARD_short_name": "IDC-2"}}, "3756": {"$update": {"ARO_description": "IDC-2 is an IDC beta-lactamase and an integron cephalosprinase."}, "$insert": {"CARD_short_name": "IDC-1"}}, "4633": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7008": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-20"}}, "2191": {"$update": {"ARO_description": "AAC(6')-Iaj is a functional acetyltransferase that modifies the amino groups at the 6' positions of aminoglycosides and contributes to aminoglycoside resistance of P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"3379": {"$update": {"dna_sequence": {"$update": {"accession": "AB709942.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iaj"}}, "2192": {"$update": {"ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "TriA"}}, "2193": {"$update": {"ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "TriB"}}, "2194": {"$update": {"ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "TriC"}}, "2195": {"$update": {"ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "OpmH"}}, "2196": {"$insert": {"CARD_short_name": "Paer_gyrA_FLO"}}, "4634": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-21"}}, "2198": {"$insert": {"CARD_short_name": "Paer_parE_FLO"}}, "253": {"$update": {"ARO_description": "Also known as vanXYG, is a vanXY variant found in the vanG gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"123": {"$update": {"dna_sequence": {"$update": {"accession": "DQ212986.1"}}}}}}}}, "model_name": "vanXY gene in vanG cluster", "ARO_name": "vanXY gene in vanG cluster"}, "$insert": {"CARD_short_name": "vanXY_in_vanG"}}, "250": {"$update": {"ARO_description": "cmr is a plasmid-encoded chloramphenicol exporter that is found in Rhodococcus fascians and Corynebacterium glutamicum.", "model_sequences": {"$update": {"sequence": {"$update": {"663": {"$update": {"dna_sequence": {"$update": {"accession": "Z12001.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Rfas_cmr"}}, "251": {"$update": {"ARO_description": "APH(3')-VIIa is a plasmid-encoded aminoglycoside phosphotransferase in C. jejuni.", "model_sequences": {"$update": {"sequence": {"$update": {"326": {"$update": {"dna_sequence": {"$update": {"accession": "M29953.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-VIIa"}}, "256": {"$update": {"ARO_description": "CMY-21 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"957": {"$update": {"dna_sequence": {"$update": {"accession": "DQ139328.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-21"}}, "257": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1735": {"$update": {"dna_sequence": {"$update": {"accession": "KM926622.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-37"}}, "254": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1923": {"$update": {"dna_sequence": {"$update": {"accession": "GQ853681.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-150"}}, "255": {"$update": {"model_name": "BRP(MBL)"}, "$insert": {"CARD_short_name": "BRP(MBL)"}}, "2200": {"$update": {"ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-VI"}}, "2201": {"$update": {"ARO_description": "PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence.", "ARO_category": {"$update": {"40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}}, "$insert": {"CARD_short_name": "PvrR"}}, "2202": {"$update": {"ARO_description": "AAC(3)-Ib/AAC(6')-Ib'' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.", "model_param": {"$update": {"40327": {"$update": {"param_description": "A parameter to describe the genes in a fusion protein. The parameter is defined by Cvterm IDs, separated by commas, with the ordering number preceding a colon. If the ordering of one or more parameters is unknown, it is designated as 0. Examples: 1:30003,2:30111 or 0:32224,0:33555."}}}}}, "$insert": {"CARD_short_name": "AAC_3Ib_AAC_6Ib"}}, "2203": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3390": {"$update": {"dna_sequence": {"$update": {"accession": "KP347127.1"}}, "protein_sequence": {"$update": {"accession": "AKF16168.1"}}}}}}}}, "model_name": "MCR-1.1"}, "$insert": {"CARD_short_name": "MCR-1.1"}}, "2205": {"$update": {"ARO_description": "MexJ is the membrane fusion protein of the MexJK multidrug efflux protein.", "ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "model_name": "MexJ"}, "$insert": {"CARD_short_name": "MexJ"}}, "2206": {"$update": {"ARO_description": "MexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein.", "ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "model_name": "MexK"}, "$insert": {"CARD_short_name": "MexK"}}, "2207": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}, "model_name": "MexV"}, "$insert": {"CARD_short_name": "MexV"}}, "2208": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}, "model_name": "MexW"}, "$insert": {"CARD_short_name": "MexW"}}, "476": {"$insert": {"CARD_short_name": "amrB"}}, "116": {"$update": {"ARO_description": "QnrB18 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"424": {"$update": {"dna_sequence": {"$update": {"accession": "AM919399.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB18"}}, "2790": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}}, "$insert": {"CARD_short_name": "Smar_Omp1"}}, "2428": {"$insert": {"CARD_short_name": "farA"}}, "2429": {"$insert": {"CARD_short_name": "farB"}}, "4812": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114l"}}, "2421": {"$insert": {"CARD_short_name": "efrA"}}, "2422": {"$insert": {"CARD_short_name": "efrB"}}, "2423": {"$insert": {"CARD_short_name": "msbA"}}, "2424": {"$update": {"ARO_category": {"$update": {"40721": {"$update": {"category_aro_description": "Microcin J25 is a peptide antibiotic that inhibits transcription by bacterial RNA polymerase. MccJ25 is produced by Escherichia coli strains that harbor a plasmid-borne antibiotic-synthesis and antibiotic-export cassette, consisting of a gene for MccJ25 precursor (a 58 residue linear peptide), two genes for factors that process MccJ25 precursor into MccJ25, and one gene for export of MccJ25."}}}}, "model_name": "YojI"}, "$insert": {"CARD_short_name": "YojI"}}, "2425": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "hmrM"}}, "2426": {"$insert": {"CARD_short_name": "efmA"}}, "2427": {"$insert": {"CARD_short_name": "efpA"}}, "4329": {"$insert": {"CARD_short_name": "ADC-51"}}, "4810": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114j"}}, "168": {"$update": {"ARO_description": "VIM-17 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"8239": {"dna_sequence": {"partial": "0", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATGATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "fmax": "1811", "accession": "EU118148.2", "fmin": "1010", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "ABW90721.1", "sequence": "MFKLLSKLLVYLTASMMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-17"}}, "169": {"$update": {"ARO_description": "IMP-33 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"8214": {"dna_sequence": {"partial": "0", "sequence": "ATGAAGAAATTATTTGTTTTATGTGTATGCTTCTTTTGTAGCATTACTGCCGCAGGATCGTCTTTACCTGATTTAAAAATTGAGAAGCTTGAAGAAGGTGTTTTTGTTCATACATCGTTCGAAGAAGTTAACGGTTGGGGGGTTGTTACTAAACACGGTTTGGTGGTGCTTGTAAACACAGACGCCTATCTAATTGACACTCCATTTACTGCTACAGACACTGAAAAATTAGTCAATTGGTTTGTGGAGCGCGGCTATAAAATCAAAGGCACTATTTCATCACATTTCCATAGCGACAGCACAGGAGGAATAGAGTGGCTTAATTCTCAATCTATTCCCACGTATGCATCTGAATTAACAAATGAACTTTTGAAAAAATCCGGTAAGGTACAAGCTAAATATTCATTTAGCGAAGTTAGCTATTGGCTAGTTAAAAATAAAATTGAAGTTTTTTATCCTGGCCCAGGTCACACTCAAGATAACCTAGTGGTTTGGTTGCCTGAAAGTAAAATTTTATTCGGTGGTTGCTTTGTTAAACCTCACGGTCTTGGCAATTTAGGTGACGCAAATTTAGAAGCTTGGCCAAAGTCCGCCAAAATATTAATGTCTAAATATGGCAAAGCAAAGCTTGTTGTTTCAAGTCATAGTGAGAAAGGGGACGCATCACTATTGAAACGTACATGGGAACAAGCTCTTAAAGGGCTTAAAGAAAGTAAAAAAACATCATCACCAAGTAACTAA", "fmax": "2568", "accession": "JN848782.2", "fmin": "1827", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AEU17778.1", "sequence": "MKKLFVLCVCFFCSITAAGSSLPDLKIEKLEEGVFVHTSFEEVNGWGVVTKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKSGKVQAKYSFSEVSYWLVKNKIEVFYPGPGHTQDNLVVWLPESKILFGGCFVKPHGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEKGDASLLKRTWEQALKGLKESKKTSSPSN"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-33"}}, "164": {"$update": {"ARO_description": "VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecium.", "model_sequences": {"$update": {"sequence": {"$update": {"684": {"$update": {"dna_sequence": {"$update": {"accession": "JF802084.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanN"}}, "165": {"$update": {"ARO_description": "VIM-29 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"935": {"$update": {"dna_sequence": {"$update": {"accession": "JX311308.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-29"}}, "167": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1099": {"$update": {"dna_sequence": {"$update": {"accession": "AB372224.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-39"}}, "160": {"$update": {"ARO_description": "OXA-236 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1374": {"$update": {"dna_sequence": {"$update": {"accession": "JQ820242.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-236"}}, "161": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1639": {"$update": {"dna_sequence": {"$update": {"accession": "EU586041.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-56"}}, "162": {"$update": {"ARO_description": "KPC-8 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1870": {"$update": {"dna_sequence": {"$update": {"accession": "FJ234412.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-8"}}, "163": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1534": {"$update": {"dna_sequence": {"$update": {"accession": "KF986257.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-376"}}, "4839": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-504"}}, "4838": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-503"}}, "4815": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114p"}}, "4529": {"$insert": {"CARD_short_name": "CTX-M-200"}}, "4528": {"$insert": {"CARD_short_name": "CTX-M-199"}}, "4527": {"$insert": {"CARD_short_name": "CTX-M-198"}}, "4526": {"$insert": {"CARD_short_name": "CTX-M-197"}}, "4525": {"$insert": {"CARD_short_name": "CTX-M-196"}}, "4524": {"$insert": {"CARD_short_name": "CTX-M-195"}}, "4523": {"$insert": {"CARD_short_name": "CTX-M-194"}}, "4522": {"$insert": {"CARD_short_name": "CTX-M-193"}}, "4521": {"$insert": {"CARD_short_name": "CTX-M-192"}}, "4520": {"$insert": {"CARD_short_name": "CTX-M-191"}}, "4422": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-36"}}, "2518": {"$update": {"model_name": "tetB(58)"}, "$insert": {"CARD_short_name": "tetB(58)"}}, "2519": {"$insert": {"CARD_short_name": "LlmA_23S_CLI"}}, "1842": {"$update": {"ARO_description": "IMI-3 is a beta-lactamase found in Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"1356": {"$update": {"dna_sequence": {"$update": {"accession": "GU015024.1"}}}}}}}}}, "$insert": {"CARD_short_name": "IMI-3"}}, "2517": {"$update": {"model_name": "tetA(58)"}, "$insert": {"CARD_short_name": "tetA(58)"}}, "1841": {"$update": {"ARO_description": "OXA-76 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1465": {"$update": {"dna_sequence": {"$update": {"accession": "AY949203.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-8"}}, "1817": {"$update": {"model_sequences": {"$update": {"sequence": {"8145": {"dna_sequence": {"partial": "0", "sequence": "ATGCTTAAAATCGACATGAAGAATGTAAAAAAATATTATGCAGATAAATTAATTTTAAATATAAAAGAACTAAAGATTTATAGTGGGGATAAAATAGGTATTGTAGGTAAGAATGGAGTTGGCAAAACAACACTTTTAAAAATAATAAAAGGACTAATAGAGATTGACGAAGGAAATATAATTATAAGTGAAAAAACAACTATTAAATATATCTCTCAATTAGAAGAACCACATAGTAAGATAATTGATGGAAAATATGCTTCAATATTTCAAGTTGAAAATAAGTGGAATGACAATATGAGTGGTGGTGAAAAAACTAGATTTAAACTAGCAGAGGGATTTCAAGATCAATGTTCTTTAATGCTCGTAGATGAACCTACAAGTAATTTAGATATCGAAGGAATAGAGTTGATAACAAATACTTTTAAAGAGTACCGTGATACTTTTTTGGTAGTATCTCATGATAGAATTTTTTTAGATCAAGTTTGTACAAAAATTTTTGAAATTGAAAATGGATATATTAGAGAATTCATCGGTAATTATACAAACTATATAGAGCAAAAAGAAATGCTTCTACGAAAGCAACAAGAAGAATACGAAAAGTATAATTCTAAAAGAAAGCAATTGGAGCAAGCTATAAAGCTAAAAGAGAATAAGGCGCAAGGAATGATTAAGCCCCCTTCAAAAACAATGGGAACATCTGAATCTAGAATATGGAAAATGCAACATGCTACTAAACAAAAAAAGATGCATAGAAATACGAAATCGTTGGAAACACGAATAGATAAATTAAATCATGTAGAAAAAATAAAAGAGCTTCCTTCTATTAAAATGGATTTACCTAATAGAGAGCAATTTCATGGTCGCAATGTAATTAGTTTAAAAAACTTATCTATAAAATTTAATAATCAATTTCTTTGGAGAGATGCTTCATTTGTCATTAAAGGTGGAGAAAAGGTTGCTATAATTGGTAACAATGGTGTAGGAAAAACAACATTGTTGAAGCTGATTCTAGAAAAAGTAGAATCAGTAATAATATCACCATCAGTTAAAATTGGATACGTCAGTCAAAACTTAGATGTTCTACAATCTCATAAATCTATCTTAGAAAATGTTATGTCTACCTCCATTCAAGATGAAACAATAGCAAGAATTGTTCTAGCAAGATTACATTTTTATCGCAATGATGTTCATAAAGAAATAAATGTTTTGAGTGGTGGAGAACAAATAAAGGTTGCTTTTGCCAAGCTATTTGTTAGCGATTGTAATACATTAATTCTTGATGAACCAACAAACTATTTGGATATCGATGCTGTTGAGGCATTAGAAGAATTGTTAATTACCTATGAAGGTGTTGTGTTATTTGCTTCCCATGATAAAAAATTTATACAAAACCTAGCTGAACAATTGTTAATAATAGAAAATAATAAAGTGAAAAAATTCGAAGGAACATATATAGAATATTTAAAAATTAAAGATAAACCAAAATTAAATACAAATGAAAAAGAACTCAAAGAAAAAAAGATGATACTAGAAATGCAAATTTCATCATTATTAAGTAAAATCTCAATGGAAGAAAATGAAGAAAAAAACAAAGAATTAGATGAAAAGTACAAATTGAAATTAAAAGAATTGAAAAGCCTAAATAAAAATATTTAA", "fmax": "2287", "accession": "U82085.2", "fmin": "628", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"accession": "AAB95639.1", "sequence": "MLKIDMKNVKKYYADKLILNIKELKIYSGDKIGIVGKNGVGKTTLLKIIKGLIEIDEGNIIISEKTTIKYISQLEEPHSKIIDGKYASIFQVENKWNDNMSGGEKTRFKLAEGFQDQCSLMLVDEPTSNLDIEGIELITNTFKEYRDTFLVVSHDRIFLDQVCTKIFEIENGYIREFIGNYTNYIEQKEMLLRKQQEEYEKYNSKRKQLEQAIKLKENKAQGMIKPPSKTMGTSESRIWKMQHATKQKKMHRNTKSLETRIDKLNHVEKIKELPSIKMDLPNREQFHGRNVISLKNLSIKFNNQFLWRDASFVIKGGEKVAIIGNNGVGKTTLLKLILEKVESVIISPSVKIGYVSQNLDVLQSHKSILENVMSTSIQDETIARIVLARLHFYRNDVHKEINVLSGGEQIKVAFAKLFVSDCNTLILDEPTNYLDIDAVEALEELLITYEGVVLFASHDKKFIQNLAEQLLIIENNKVKKFEGTYIEYLKIKDKPKLNTNEKELKEKKMILEMQISSLLSKISMEENEEKNKELDEKYKLKLKELKSLNKNI"}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vgaB"}}, "1810": {"$update": {"ARO_description": "VIM-15 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1164": {"$update": {"dna_sequence": {"$update": {"accession": "EU419745.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-15"}}, "1811": {"$update": {"ARO_description": "CARB-2 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1096": {"$update": {"dna_sequence": {"$update": {"accession": "DQ157752.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-2"}}, "1812": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1557": {"$update": {"dna_sequence": {"$update": {"accession": "AB364006.1"}}}}}}}}, "model_name": "KHM-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KHM-1"}}, "1813": {"$update": {"ARO_description": "MOX-4 is a beta-lactamase found in Aeromonas caviae.", "model_sequences": {"$update": {"sequence": {"$update": {"1199": {"$update": {"dna_sequence": {"$update": {"accession": "FJ262599.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-4"}}, "4339": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6714": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ADC-83"}}, "1818": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2105": {"$update": {"dna_sequence": {"$update": {"accession": "KP096411.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-26"}}, "1819": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-3"}}, "1208": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1390": {"$update": {"dna_sequence": {"$update": {"accession": "KF513178.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-173"}}, "4336": {"$insert": {"CARD_short_name": "ADC-66"}}, "4337": {"$insert": {"CARD_short_name": "ADC-70"}}, "4334": {"$insert": {"CARD_short_name": "ADC-63"}}, "5370": {"$insert": {"CARD_short_name": "PDC-232"}}, "4335": {"$insert": {"CARD_short_name": "ADC-65"}}, "1098": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"107": {"$update": {"dna_sequence": {"$update": {"accession": "KF823969.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanB"}}, "1899": {"$update": {"ARO_description": "Also known as vanYF, is a vanY variant found in the vanF gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"380": {"$update": {"dna_sequence": {"$update": {"accession": "AF155139.1"}}}}}}}}, "model_name": "vanY gene in vanF cluster", "ARO_name": "vanY gene in vanF cluster"}, "$insert": {"CARD_short_name": "vanY_in_vanF_cl"}}, "1099": {"$update": {"ARO_description": "OXA-48 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8249": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTGTATTAGCCTTATCGGCTGTGTTTTTGGTGGCATCGATTATCGGAATGCCTGCGGTAGCAAAGGAATGGCAAGAAAACAAAAGTTGGAATGCTCACTTTACTGAACATAAATCACAGGGCGTAGTTGTGCTCTGGAATGAGAATAAGCAGCAAGGATTTACCAATAATCTTAAACGGGCGAACCAAGCATTTTTACCCGCATCTACCTTTAAAATTCCCAATAGCTTGATCGCCCTCGATTTGGGCGTGGTTAAGGATGAACACCAAGTCTTTAAGTGGGATGGACAGACGCGCGATATCGCCACTTGGAATCGCGATCATAATCTAATCACCGCGATGAAATATTCAGTTGTGCCTGTTTATCAAGAATTTGCCCGCCAAATTGGCGAGGCACGTATGAGCAAGATGCTACATGCTTTCGATTATGGTAATGAGGACATTTCGGGCAATGTAGACAGTTTCTGGCTCGACGGTGGTATTCGAATTTCGGCCACGGAGCAAATCAGCTTTTTAAGAAAGCTGTATCACAATAAGTTACACGTATCGGAGCGCAGCCAGCGTATTGTCAAACAAGCCATGCTGACCGAAGCCAATGGTGACTATATTATTCGGGCTAAAACTGGATACTCGACTAGAATCGAACCTAAGATTGGCTGGTGGGTCGGTTGGGTTGAACTTGATGATAATGTGTGGTTTTTTGCGATGAATATGGATATGCCCACATCGGATGGTTTAGGGCTGCGCCAAGCCATCACAAAAGAAGTGCTCAAACAGGAAAAAATTATTCCCTAG", "fmax": "2985", "accession": "AY236073.2", "fmin": "2187", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAP70012.1", "sequence": "MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-48"}}, "4330": {"$insert": {"CARD_short_name": "ADC-52"}}, "5558": {"$insert": {"CARD_short_name": "PDC-428"}}, "4331": {"$insert": {"CARD_short_name": "ADC-53"}}, "2803": {"$update": {"ARO_category": {"$update": {"40948": {"$update": {"category_aro_name": "Para-aminosalicylic acid", "category_aro_description": "Para-aminosalicylic acid (PAS) is an anti-tubercular antibiotic agent, often used in conjunction with Isoniazid for treatment of M. tuberculosis infections. PAS diminishes bacterial cell growth by limiting folic acid production."}}}}}, "$insert": {"CARD_short_name": "Mtub_thyA_PAS"}}, "1609": {"$update": {"ARO_description": "QnrC is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"508": {"$update": {"dna_sequence": {"$update": {"accession": "EU917444.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrC"}}, "1608": {"$insert": {"CARD_short_name": "MexT"}}, "4987": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7362": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-674"}}, "1979": {"$update": {"ARO_description": "FosA4 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule.", "model_sequences": {"$update": {"sequence": {"$update": {"1439": {"$update": {"dna_sequence": {"$update": {"accession": "AB908992.1"}}}}}}}}}, "$insert": {"CARD_short_name": "FosA4"}}, "1978": {"$update": {"ARO_description": "OXA-200 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1294": {"$update": {"dna_sequence": {"$update": {"accession": "HQ734811.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-200"}}, "1601": {"$update": {"ARO_description": "LRA-1 is a beta-lactamase isolated from soil samples in Alaska.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-1"}}, "1600": {"$insert": {"CARD_short_name": "Paer_PhoP_CST"}}, "1603": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1564": {"$update": {"dna_sequence": {"$update": {"accession": "DQ328802.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-86"}}, "1602": {"$update": {"ARO_description": "AAC(6')-Iai is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"708": {"$update": {"dna_sequence": {"$update": {"accession": "EU886977.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iai"}}, "1605": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1501": {"$update": {"dna_sequence": {"$update": {"accession": "AY227051.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cphA5"}}, "1604": {"$update": {"ARO_description": "CTX-M-84 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"1257": {"$update": {"dna_sequence": {"$update": {"accession": "FJ214367.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-84"}}, "1607": {"$update": {"ARO_description": "PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"692": {"$update": {"dna_sequence": {"$update": {"accession": "JN645776.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40661": {"$update": {"category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}}}}}, "$insert": {"CARD_short_name": "Spne_PBP1a_AMX"}}, "1606": {"$update": {"ARO_description": "CTX-M-16 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"767": {"$update": {"dna_sequence": {"$update": {"accession": "AY029068.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-16"}}, "809": {"$update": {"ARO_description": "lnuB is a plasmid-mediated nucleotidyltransferase found in Streptococcus lutetiensis."}, "$insert": {"CARD_short_name": "lnuB"}}, "808": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1244": {"$update": {"dna_sequence": {"$update": {"accession": "GQ149347.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-171"}}, "803": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1409": {"$update": {"dna_sequence": {"$update": {"accession": "AY227050.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cphA4"}}, "802": {"$update": {"ARO_description": "QnrA3 is a plasmid-mediated quinolone resistance protein found in Shewanella algae.", "model_sequences": {"$update": {"sequence": {"$update": {"510": {"$update": {"dna_sequence": {"$update": {"accession": "DQ058661.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrA3"}}, "801": {"$update": {"ARO_description": "mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis.", "model_sequences": {"$update": {"sequence": {"$update": {"4588": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "mfpA"}}, "800": {"$update": {"ARO_description": "CTX-M-87 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1479": {"$update": {"dna_sequence": {"$update": {"accession": "EU545409.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-87"}}, "807": {"$update": {"ARO_description": "OKP-B-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8216": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAGGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCATGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCCGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGTTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGGGATACCGCGGCGACCATGGCCGAACGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAG", "fmax": "861", "accession": "AJ635402.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAG25813.2", "sequence": "MRYVRLCLISLIAALPLAVFASPQPLEQIKISEGQLAGRVGYVEMDLASGRMLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTAATMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-1"}}, "806": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1064": {"$update": {"dna_sequence": {"$update": {"accession": "JX121117.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-150"}}, "805": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"52": {"$update": {"dna_sequence": {"$update": {"accession": "U57969.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MexC"}}, "804": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"473": {"$update": {"dna_sequence": {"$update": {"accession": "L20800.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tetB(P)"}}, "2848": {"$update": {"model_name": "MCR-4.1"}, "$insert": {"CARD_short_name": "MCR-4.1"}}, "2849": {"$update": {"model_name": "MCR-5.1"}, "$insert": {"CARD_short_name": "MCR-5.1"}}, "2846": {"$insert": {"CARD_short_name": "BUT-1"}}, "1849": {"$update": {"ARO_description": "Specific mutations that arise in Mycobacterium tuberculosis tlyA resulting in aminoglycosides resistance.", "model_sequences": {"$update": {"sequence": {"$update": {"2076": {"$update": {"dna_sequence": {"$update": {"accession": "AE000516.1"}}}}}}}}, "ARO_category": {"$update": {"40036": {"$update": {"category_aro_description": "tlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA."}}}}}, "$insert": {"CARD_short_name": "Mtub_tlyA_AMG"}}, "2844": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5508": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Cereibacter sphaeroides 2.4.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Rsph_ampC_BLA"}}, "2845": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Lhon_ampC_BLA"}}, "2842": {"$update": {"ARO_category": {"$update": {"41452": {"$update": {"category_aro_name": "Subclass B1 Vibrio cholerae varG beta-lactamase"}}}}}, "$insert": {"CARD_short_name": "Vcho_varG"}}, "2843": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "Escherichia coli ampC beta-lactamase"}, "$insert": {"CARD_short_name": "Ecol_ampC_BLA"}}, "2840": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4191": {"$update": {"dna_sequence": {"$update": {"accession": "AY027589.1"}}, "protein_sequence": {"$update": {"accession": "AAK14791.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NPS-1"}}, "2841": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to chloramphenicol.", "model_sequences": {"$update": {"sequence": {"$update": {"4193": {"$update": {"dna_sequence": {"$update": {"accession": "AE014075.1"}}}}}}}}, "ARO_category": {"$update": {"41350": {"$update": {"category_aro_description": "Point mutations in the 23S rRNA subunit shown clinically to confer resistance to phenicol class antibiotics, including chloramphenicol and florfenicol, by disrupting antibiotic binding-site affinity."}}}}}, "$insert": {"CARD_short_name": "Ecol_23S_CHL"}}, "3320": {"$update": {"ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS10"}}, "3321": {"$update": {"ARO_description": "AAC(3)-IIe is a plasmid-encoded aminoglycoside acetyltransferase in E. coli."}, "$insert": {"CARD_short_name": "AAC(3)-IIe"}}, "5474": {"$insert": {"CARD_short_name": "PDC-344"}}, "3323": {"$update": {"ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS11"}}, "3324": {"$update": {"ARO_description": "Erm(49) is an rRNA methylase gene."}, "$insert": {"CARD_short_name": "Erm(49)"}}, "5473": {"$insert": {"CARD_short_name": "PDC-343"}}, "3326": {"$update": {"ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS15"}}, "5471": {"$insert": {"CARD_short_name": "PDC-341"}}, "3328": {"$insert": {"CARD_short_name": "AAC(6')-Im"}}, "3329": {"$update": {"model_name": "Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin"}, "$insert": {"CARD_short_name": "Mgen_parC_MXF"}}, "5478": {"$insert": {"CARD_short_name": "PDC-349"}}, "5479": {"$insert": {"CARD_short_name": "PDC-35"}}, "1775": {"$update": {"ARO_description": "QnrS7 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"348": {"$update": {"dna_sequence": {"$update": {"accession": "KF730651.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS7"}}, "1774": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1271": {"$update": {"dna_sequence": {"$update": {"accession": "HQ913565.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-106"}}, "1777": {"$update": {"ARO_description": "OXA-177 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"968": {"$update": {"dna_sequence": {"$update": {"accession": "HM113563.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-177"}}, "1776": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1788": {"$update": {"dna_sequence": {"$update": {"accession": "JX121126.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-159"}}, "1771": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"928": {"$update": {"dna_sequence": {"$update": {"accession": "JX042489.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-19"}}, "1770": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1644": {"$update": {"dna_sequence": {"$update": {"accession": "AY368236.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-127"}}, "1773": {"$insert": {"CARD_short_name": "tet(43)"}}, "1772": {"$update": {"ARO_description": "aadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"13": {"$update": {"dna_sequence": {"$update": {"accession": "AY758206.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA11"}}, "1779": {"$update": {"ARO_description": "CTX-M-12 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1008": {"$update": {"dna_sequence": {"$update": {"accession": "AF305837.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-12"}}, "1778": {"$update": {"ARO_description": "OKP-A-5 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1598": {"$update": {"dna_sequence": {"$update": {"accession": "AM051143.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-5"}}, "3972": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-217"}}, "3975": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-202"}}, "3957": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-214"}}, "3974": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumonia. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-221"}}, "5142": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-843"}}, "1159": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1796": {"$update": {"dna_sequence": {"$update": {"accession": "AJ746225.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-129"}}, "1158": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1474": {"$update": {"dna_sequence": {"$update": {"accession": "AF117746.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-22"}}, "1155": {"$update": {"ARO_description": "ACT-9 is a beta-lactamase found in Pantoea agglomerans.", "model_sequences": {"$update": {"sequence": {"$update": {"819": {"$update": {"dna_sequence": {"$update": {"accession": "HQ693810.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-9"}}, "1154": {"$update": {"model_sequences": {"$update": {"sequence": {"8177": {"dna_sequence": {"partial": "0", "sequence": "ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTCCGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCACGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "fmax": "861", "accession": "DQ105529.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAZ14084.2", "sequence": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLPDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-146"}}, "1157": {"$update": {"ARO_description": "VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.", "model_sequences": {"$update": {"sequence": {"$update": {"300": {"$update": {"dna_sequence": {"$update": {"accession": "DQ212986.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanG"}}, "1156": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"249": {"$update": {"dna_sequence": {"$update": {"accession": "AF079138.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Erm(31)"}}, "1151": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1684": {"$update": {"dna_sequence": {"$update": {"accession": "JX089628.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-240"}}, "1150": {"$update": {"ARO_description": "QnrVC5 is an integron-mediated quinolone resistance protein found in Vibrio fluvialis.", "model_sequences": {"$update": {"sequence": {"$update": {"572": {"$update": {"dna_sequence": {"$update": {"accession": "JN408080.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrVC5"}}, "1153": {"$update": {"ARO_description": "KPC-3 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1192": {"$update": {"dna_sequence": {"$update": {"accession": "AF395881.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-3"}}, "1152": {"$update": {"ARO_description": "CTX-M-39 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1431": {"$update": {"dna_sequence": {"$update": {"accession": "AY954516.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-39"}}, "5519": {"$insert": {"CARD_short_name": "PDC-39"}}, "5518": {"$insert": {"CARD_short_name": "PDC-389"}}, "5368": {"$insert": {"CARD_short_name": "PDC-229"}}, "2807": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clarithromycin, a macrolide antibiotic."}, "$insert": {"CARD_short_name": "Ecol_23S_CLR"}}, "5511": {"$insert": {"CARD_short_name": "PDC-381"}}, "1555": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6223": {"$update": {"dna_sequence": {"$update": {"accession": "JN051143.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-140"}}, "5513": {"$insert": {"CARD_short_name": "PDC-383"}}, "5512": {"$insert": {"CARD_short_name": "PDC-382"}}, "5515": {"$insert": {"CARD_short_name": "PDC-386"}}, "5514": {"$insert": {"CARD_short_name": "PDC-385"}}, "5517": {"$insert": {"CARD_short_name": "PDC-388"}}, "5516": {"$insert": {"CARD_short_name": "PDC-387"}}, "1551": {"$update": {"ARO_description": "OXA-78 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1616": {"$update": {"dna_sequence": {"$update": {"accession": "AY862132.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-78"}}, "1550": {"$update": {"ARO_description": "smeR is the responder component of a two component signal transduction system that includes smeS.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "smeR"}}, "1553": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"619": {"$update": {"dna_sequence": {"$update": {"accession": "L09756.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tetS"}}, "1552": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1597": {"$update": {"dna_sequence": {"$update": {"accession": "AF441286.1"}}}}}}}}, "model_name": "MUS-1"}, "$insert": {"CARD_short_name": "MUS-1"}}, "59": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1685": {"$update": {"dna_sequence": {"$update": {"accession": "HE616889.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-256"}}, "58": {"$update": {"ARO_description": "QnrB47 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"147": {"$update": {"dna_sequence": {"$update": {"accession": "JX440358.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB47"}}, "1557": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"917": {"$update": {"dna_sequence": {"$update": {"accession": "LN515533.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-187"}}, "1556": {"$update": {"ARO_description": "VIM-13 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1005": {"$update": {"dna_sequence": {"$update": {"accession": "DQ365886.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-13"}}, "55": {"$update": {"ARO_description": "OXA-69 is a beta-lactamase found in A. baumannii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-69"}}, "54": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1160": {"$update": {"dna_sequence": {"$update": {"accession": "KC292503.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-34"}}, "57": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1637": {"$update": {"dna_sequence": {"$update": {"accession": "AB023477.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-24"}}, "56": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-7"}}, "51": {"$update": {"ARO_description": "AAC(3)-IIIc is an aminoglycoside acetyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"9": {"$update": {"dna_sequence": {"$update": {"accession": "L06161.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-IIIc"}}, "50": {"$update": {"ARO_description": "SME-2 is a beta-lactamase found in Serratia marcescens.", "model_sequences": {"$update": {"sequence": {"$update": {"1396": {"$update": {"dna_sequence": {"$update": {"accession": "AF275256.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SME-2"}}, "53": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1286": {"$update": {"dna_sequence": {"$update": {"accession": "GQ152600.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-5"}}, "52": {"$update": {"ARO_description": "OXY-2-2 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1220": {"$update": {"dna_sequence": {"$update": {"accession": "AF473577.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-2"}}, "537": {"$update": {"ARO_description": "OXA-120 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1203": {"$update": {"dna_sequence": {"$update": {"accession": "HE963768.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-120"}}, "536": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"933": {"$update": {"dna_sequence": {"$update": {"accession": "AJ308558.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-95"}}, "535": {"$update": {"ARO_description": "Point mutation in Morganella morganii resulting in fluoroquinolone resistance.", "model_name": "Morganella morganii gyrB conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Mmor_gyrB_FLO"}}, "534": {"$update": {"ARO_description": "Also known as vanVB, is a vanV variant found in the vanB gene cluster. It is found in some but not all vanB operons in E. faecalis, suggesting the existence of varied gene compositions in vanB operons.", "model_sequences": {"$update": {"sequence": {"$update": {"4564": {"$update": {"dna_sequence": {"$update": {"accession": "AE016830.1"}}}}}}}}, "model_name": "vanV gene in vanB cluster", "ARO_name": "vanV gene in vanB cluster"}, "$insert": {"CARD_short_name": "vanV_in_vanB_cl"}}, "533": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4562": {"$update": {"dna_sequence": {"$update": {"accession": "HF953351.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-16"}}, "532": {"$update": {"ARO_description": "CTX-M-47 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"825": {"$update": {"dna_sequence": {"$update": {"accession": "AY847143.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-47"}}, "531": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"673": {"$update": {"dna_sequence": {"$update": {"accession": "Z48231.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SAT-3"}}, "530": {"$update": {"ARO_description": "VIM-11 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"8189": {"dna_sequence": {"partial": "0", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAGCGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "fmax": "928", "accession": "AY605049.2", "fmin": "127", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AAT36613.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGSEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-11"}}, "539": {"$update": {"ARO_description": "QnrB59 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"574": {"$update": {"dna_sequence": {"$update": {"accession": "JX259320.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB59"}}, "3299": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Kpne_KpnH"}}, "4691": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7066": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-64"}}, "5139": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-840"}}, "1558": {"$update": {"model_sequences": {"$update": {"sequence": {"8183": {"dna_sequence": {"partial": "0", "sequence": "TTGCTGATTAAAAAGAATGCTTTATCAATATTAAAAATCGTTTTTCCTATTGCTGTTTTGCTATTTGTTATTTATCAATCGAAAAAAGAACTGACAAATCTGTCATTCAAACGTACGCTCATGGTCATCAACGGACTGGAACGAACGGATTTATTCATGCTTGTGTTGATCGGCTTGCTGGCTGTTGCGGCTATGTCGCTGTATGATTACGTCCTGAAGTACTCACTGCGCCTATCGATCACAAACGGAAAAGTTTTCAGGGTTTCCTGGATCGCCAATTCATTTAATAATGTGTTGGGATTCGGCGGTTTAGCCGGAGTCGGGTTAAGAATGATGTTCTATAAGGAGCATACGAAAGACCATAAGGCACTCGTGAAAGGAATCGCCTGGCTCACATCATCTATGCTGCTCGGATTATCTGTTTTCAGCATTTTCGTTGCTGCGAGAGTGCTGCCAGTTGATGAAGTGATTCATGAGAAGCCTTGGCTGTGGGCGGTCGTTATCGGTTTTGCACTGATATTGCCGTTATCTTTAGCGGTGTCCAAAATAAAAGACCGCAAAGCTGGGGACGAAGAGAATGCGGATAAAGTGAAAAATCCGATTTTCGCATATATTGGAGCTTCAGTTGTTGAATGGCTCATGGCCGGGACCGTCATCTATTTTGCTTTGTTCGCTATGGGCATTCATGCAGATATCAGGTATGTGTTCGGGGTGTTCGTCATTGCGGCGATCGGAGGAATGATCAGCCTCGTGCCGGGCGGCTTCGGCTCGTTTGACCTTTTATTTTTGCTGGGGATGGAGCAGCTTGGCTATCATCAAGAGGCCATCGTTACTTCTATTGTGTTGTACAGGCTCGCCTACTCATTTATCCCATTTATCTTGGGACTGTTCTTTGCCGCCGGCGACCTGACGGAAAATACAATGAAGCGGCTCGAAACGAACCCGCGCATCGCACCGGCAATTGAGACGACAAACGTTCTGCTTGTTGTTCAGCGTGCGGTATTAGTGAGAATTTTGCAAGGCTCGCTTTCCCTTATTGTGTTCGTAGCAGGTCTGATTGTCTTGGCCTCAGTTTCCTTGCCGATTGACAGGCTGACGGTTATACCGCACATTCCGCGCCCGGCGCTTTTGCTGTTCAACGGCCTGTCCTTAAGCTCAGCGCTCATTCTGCTCATTTTGCCGATCGAGCTTTATAAACGGACAAAACGTTCCTACACGATGGCCATTACAGCGCTTGTCGGCGGCTTTGTGTTCAGCTTTTTAAAAGGGCTTAACATCAGCGCGATATTCGTACTGCCGATGATTATCGTATTGCTTGTGCTATTGAAAAAACAATTTGTCCGCGAACAGGCATCCTATACACTGGGACAATTGATATTCGCTGTGGCGCTGTTTACTGTGGCGCTCTTTAACTACAATCTGATCGCGGGCTTTATTTGGGACCGGATGAAGAAGGTGCTGCGTCACGAATATTTCGTCCACAGCACCTCGCATATTACACATGCAACCATCATGGCGATCATCATTGTGCCGCTGTTCTTCTTGATATTTACAGTGGTCTATCATAAGAGAACGAAACCGATCGGAGAGAAAGCTGACCCTGAGCGTCTTGCTGCGTTTCTCAATGAAAAAGGCGGCAACGCGCTGAGCCATCTTGGTTTTCTTGGAGATAAGCGGTTTTATTTTTCTAGCGATGGAAATGCACTGCTTCTGTTTGGGAAAATCGCCAGAAGGCTGGTCGTGCTCGGCGATCCATCTGGCCAAAGAGAATCATTCCCGCTCGTGCTGGAAGAATTTCTGAACGAAGCGCATCAGAAGGGATTCAGTGTTTTGTTCTATCAAATTGAACGAGAGGACATGGCGCTGTATCACGATTTTGGCTACAACTTCTTTAAATTGGGTGAGGAAGCATATGTAGATTTAAATACATTTACCTTGACTGGGAAGAAAAAAGCCGGCCTTCGGGCAATCAATAACCGCTTTGAGCGGGAGGAGTATACTTTCCATGTGGATCATCCCCCATTTTCTGATGCGTTTTTGGAGGAGCTGAAGCAAATCTCAGACGAATGGCTCGGCTCGAAAAAAGAGAAGGGATTCTCGCTCGGATTTTTTGATCCTTCCTATTTACAGAAAGCGCCGATCGCCTATATGAAAAATGCAGAAGGAGAGATCGTTGCATTCGCAAATGTCATGCCGATGTACCAGGAAGGAGAGATATCGGTCGATCTGATGCGCTATCGCGGCGACGCTCCAAATGGCATTATGGACGCATTGTTTATCCGTATGTTTTTATGGGCAAAGGAAGAGGGCTGTACGTCATTTAATATGGGGATGGCACCCTTGGCCAATGTCGGCACTGCCTTTACATCCTTCTGGTCCGAAAGGTTTGCCGCTGTCATTTTTAATAATGTCAGATACATGTACAGTTTCAGCGGCCTAAGAGCCTTTAAAGAAAAATATAAACCGGAGTGGCGAGGGAAATACTTAGCGTATCGGAAAAACAGATCTCTTTCTGTCACCATGTTCCTCGTTACACGTCTGATTGGCAAAAGCAAAAAAGACTCCGTCTAA", "fmax": "919348", "accession": "AL009126.3", "fmin": "916777", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacillus subtilis subsp. subtilis str. 168", "NCBI_taxonomy_id": "224308", "NCBI_taxonomy_cvterm_id": "39579"}, "protein_sequence": {"accession": "CAX52582.1", "sequence": "MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVINGLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFGGLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEKPWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTVIYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAIVTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAVLVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLILPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAIIIVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDGNALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYHDFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEELKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEISVDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAAVIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV"}}}}}}, "$insert": {"CARD_short_name": "Bsub_mprF"}}, "5138": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-839"}}, "5605": {"$insert": {"CARD_short_name": "PDC-64"}}, "5604": {"$insert": {"CARD_short_name": "PDC-60"}}, "5607": {"$insert": {"CARD_short_name": "PDC-94"}}, "5606": {"$insert": {"CARD_short_name": "PDC-71"}}, "5601": {"$insert": {"CARD_short_name": "PDC-475"}}, "5600": {"$insert": {"CARD_short_name": "PDC-474"}}, "5603": {"$insert": {"CARD_short_name": "PDC-58"}}, "5602": {"$insert": {"CARD_short_name": "PDC-476"}}, "9": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1584": {"$update": {"dna_sequence": {"$update": {"accession": "LC004922.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-35"}}, "5609": {"$insert": {"CARD_short_name": "PDC-96"}}, "5135": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-833"}}, "3297": {"$insert": {"CARD_short_name": "erm(46)"}}, "1419": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "model_sequences": {"$update": {"sequence": {"$update": {"2122": {"$update": {"dna_sequence": {"$update": {"accession": "LC037981.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-454"}}, "3290": {"$insert": {"CARD_short_name": "tet(53)"}}, "5132": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7507": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-830"}}, "429": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mdsA"}}, "428": {"$update": {"ARO_description": "OXY-2-7 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1618": {"$update": {"dna_sequence": {"$update": {"accession": "Z49084.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-7"}}, "3292": {"$insert": {"CARD_short_name": "tet(54)"}}, "1399": {"$update": {"ARO_description": "OXA-315 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1531": {"$update": {"dna_sequence": {"$update": {"accession": "KF057032.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-2"}}, "420": {"$update": {"ARO_description": "CTX-M-1 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1916": {"$update": {"dna_sequence": {"$update": {"accession": "X92506.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-1"}}, "423": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1012": {"$update": {"dna_sequence": {"$update": {"accession": "KM087852.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-16"}}, "422": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"951": {"$update": {"dna_sequence": {"$update": {"accession": "JX049131.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-10"}}, "1393": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1081": {"$update": {"dna_sequence": {"$update": {"accession": "AJ250876.1"}}}}}}}}, "model_name": "THIN-B", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "THIN-B"}}, "1392": {"$update": {"ARO_description": "aadA22 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in S. enterica and E. coli.", "model_sequences": {"$update": {"sequence": {"$update": {"238": {"$update": {"dna_sequence": {"$update": {"accession": "AM261837.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA22"}}, "427": {"$update": {"ARO_description": "OCH-7 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi.", "model_sequences": {"$update": {"sequence": {"$update": {"1900": {"$update": {"dna_sequence": {"$update": {"accession": "AJ295345.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Brucella anthropi"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36233": {"$update": {"category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi."}}}}}, "$insert": {"CARD_short_name": "OCH-7"}}, "426": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4533": {"$update": {"dna_sequence": {"$update": {"accession": "AL009126.1"}}}}}}}}, "ARO_category": {"$update": {"36364": {"$update": {"category_aro_description": "Nucelotidylylation of streptomycin at the hydroxyl group at position 6."}}}}}, "$insert": {"CARD_short_name": "aadK"}}, "3812": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ROB-5"}}, "3816": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ROB-10"}}, "3817": {"$insert": {"CARD_short_name": "Tthe_uL3_PLM"}}, "3814": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ROB-9"}}, "3815": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-4"}}, "3456": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-293"}}, "3457": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-294"}}, "4299": {"$insert": {"CARD_short_name": "ADC-234"}}, "4298": {"$insert": {"CARD_short_name": "ADC-233"}}, "4295": {"$insert": {"CARD_short_name": "ADC-230"}}, "4294": {"$insert": {"CARD_short_name": "ADC-229"}}, "4297": {"$insert": {"CARD_short_name": "ADC-232"}}, "4296": {"$insert": {"CARD_short_name": "ADC-231"}}, "4291": {"$insert": {"CARD_short_name": "ADC-226"}}, "4290": {"$insert": {"CARD_short_name": "ADC-225"}}, "4293": {"$insert": {"CARD_short_name": "ADC-228"}}, "4292": {"$insert": {"CARD_short_name": "ADC-227"}}, "1503": {"$update": {"ARO_description": "LEN-4 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"5855": {"$update": {"dna_sequence": {"$update": {"accession": "AY130287.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-69"}}, "590": {"$update": {"ARO_description": "IND-6 is a beta-lactamase found in Chryseobacterium indologenes.", "model_sequences": {"$update": {"sequence": {"8287": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAGAAGAATTCAGTTCTTTATGGTTTCAATGATGCTTACCCCATTATTCAGTGCCCAGGTAAAAGATTTTGTAATTGAACCGCCAATAAAAAAGAACTTATATATTTATAAAACTTTCGGAGTGTTCGGGGGAAAAGAATATTCTGCCAATTCAGTGTATCTTGTCACCAAAACCGGGGTTGTTTTATTTGATGTTCCCTGGGAAAAAGCGCAATACCAAAGCCTGATGGATACCATCAAAAAACGTCATAATTTACCTGTTGTTGCGGTATTTGCGACACATTCCCATGATGACCGGGCAGGAGATTTAAGCTTTTTCAATAATAAAGGAATTAAAACCTATGCTACTCCTAAAACCAATCAATTTCTGAAAAGAGACGGAAAGGCTACTTCTACAGAGCTCATTAAGCCCGGAAAACCTTACCGCTTTGGCGGAGAGGAATTTGTAGTGGATTTTCTTGGTGAAGGGCATACTGCCGATAATGTAGTGGTATGGTTTCCAAAATATAAAGTGCTGGATGGCGGCTGCCTTGTAAAAAGCAATTCAGCTACCGATTTAGGGTATATCAAAGAAGCTAATCTAGAGCAATGGCCTAAAACCATGCATAAACTGAAAACAAAATATTCAGAAGCAGTATTAATTATTCCCGGACATGATGAATGGAAAGGCGGCGGGCACGTTGAACATACTTTGGAGCTGCTGGATAAGAAATAA", "fmax": "1011", "accession": "AM087455.2", "fmin": "291", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Chryseobacterium indologenes", "NCBI_taxonomy_id": "253", "NCBI_taxonomy_cvterm_id": "36916"}, "protein_sequence": {"accession": "CAJ32373.2", "sequence": "MKRRIQFFMVSMMLTPLFSAQVKDFVIEPPIKKNLYIYKTFGVFGGKEYSANSVYLVTKTGVVLFDVPWEKAQYQSLMDTIKKRHNLPVVAVFATHSHDDRAGDLSFFNNKGIKTYATPKTNQFLKRDGKATSTELIKPGKPYRFGGEEFVVDFLGEGHTADNVVVWFPKYKVLDGGCLVKSNSATDLGYIKEANLEQWPKTMHKLKTKYSEAVLIIPGHDEWKGGGHVEHTLELLDKK"}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-6"}}, "258": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1926": {"$update": {"dna_sequence": {"$update": {"accession": "FR853176.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-874"}}, "4749": {"$insert": {"CARD_short_name": "LHK-4"}}, "4748": {"$insert": {"CARD_short_name": "LHK-3"}}, "4743": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-27"}}, "4741": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-82"}}, "4740": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-81"}}, "4747": {"$insert": {"CARD_short_name": "LHK-2"}}, "4746": {"$insert": {"CARD_short_name": "LHK-1"}}, "4745": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-31"}}, "4744": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-28"}}, "3302": {"$insert": {"CARD_short_name": "tet(56)"}}, "4697": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-71"}}, "4715": {"$insert": {"CARD_short_name": "KLUC-2"}}, "2183": {"$update": {"ARO_description": "This inducible cluster confers resistance to vancomycin but organisms remain sensitive to teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac.  Sensitivity to teicoplanin is due to lack of binding to the sensor kinase VanS. The vanB gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSYWHBX."}, "$insert": {"CARD_short_name": "vanB_cluster"}}, "2182": {"$update": {"ARO_description": "Homologous to vanA, contains a D-Ala-D-Lac ligase.  This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin. Gene orientation: vanRSYHDX."}, "$insert": {"CARD_short_name": "vanD_cluster"}}, "2181": {"$update": {"ARO_description": "Homologous to vanA, contains a D-Ala-D-Lac ligase. The vanF gene cluster is inducible and confers high resistance to vancomycin in Paenibacillus popilliae. vanF organisms remain susceptible to teicoplanin. Gene orientation: RSYZHFX."}, "$insert": {"CARD_short_name": "vanF_cluster"}}, "2180": {"$update": {"ARO_description": "Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes. Gene orientation: vanL(XY)TmTrRS."}, "$insert": {"CARD_short_name": "vanL_cluster"}}, "2186": {"$update": {"ARO_description": "Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes. Gene orientation: vanRSYWGYT."}, "$insert": {"CARD_short_name": "vanG_cluster"}}, "229": {"$update": {"ARO_description": "Also known as vanTmL, is a vanT variant found in the vanL gene cluster. vanTmL codes for the membrane-binding domain of vanTL.", "model_sequences": {"$update": {"sequence": {"$update": {"301": {"$update": {"dna_sequence": {"$update": {"accession": "EU250284.1"}}}}}}}}, "model_name": "vanTm gene in vanL cluster", "ARO_name": "vanTm gene in vanL cluster"}, "$insert": {"CARD_short_name": "vanTm_in_vanL"}}, "228": {"$update": {"ARO_description": "SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "sdiA"}}, "227": {"$update": {"ARO_description": "OKP-B-3 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1521": {"$update": {"dna_sequence": {"$update": {"accession": "AM051152.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-3"}}, "226": {"$update": {"ARO_description": "OXA-113 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1832": {"$update": {"dna_sequence": {"$update": {"accession": "EF653400.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-113"}}, "225": {"$insert": {"CARD_short_name": "CTX-M-88"}}, "224": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1733": {"$update": {"dna_sequence": {"$update": {"accession": "AY227752.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-2"}}, "223": {"$update": {"ARO_description": "GES-3 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1708": {"$update": {"dna_sequence": {"$update": {"accession": "AB113580.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-3"}}, "222": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1483": {"$update": {"dna_sequence": {"$update": {"accession": "AY028464.1"}}}}}}}}, "model_name": "JOHN-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "JOHN-1"}}, "221": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1194": {"$update": {"dna_sequence": {"$update": {"accession": "KF526113.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-100"}}, "220": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1961": {"$update": {"dna_sequence": {"$update": {"accession": "AF143804.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-92"}}, "2213": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "opmE"}}, "2212": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mexQ"}}, "2211": {"$update": {"ARO_description": "MexP is the membrane fusion protein of the MexPQ-OpmE multidrug efflux complex.", "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mexP"}}, "2217": {"$insert": {"CARD_short_name": "mexN"}}, "2216": {"$insert": {"CARD_short_name": "mexM"}}, "2215": {"$update": {"model_name": "Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Paer_ParC_FLO"}}, "2219": {"$update": {"ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "model_name": "MexL"}, "$insert": {"CARD_short_name": "MexL"}}, "2337": {"$insert": {"CARD_short_name": "ADC-4"}}, "5475": {"$insert": {"CARD_short_name": "PDC-345"}}, "5431": {"$insert": {"CARD_short_name": "PDC-300"}}, "864": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1701": {"$update": {"dna_sequence": {"$update": {"accession": "JF460795.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-61"}}, "151": {"$update": {"ARO_description": "OKP-A-15 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1200": {"$update": {"dna_sequence": {"$update": {"accession": "FJ755841.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-15"}}, "150": {"$update": {"ARO_description": "catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catB3"}}, "153": {"$insert": {"CARD_short_name": "adeF"}}, "152": {"$insert": {"CARD_short_name": "cpxA"}}, "155": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1402": {"$update": {"dna_sequence": {"$update": {"accession": "JN935137.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-195"}}, "154": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mgrA"}}, "157": {"$update": {"ARO_description": "dfrA21 is an integron-encoded dihydrofolate reductase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"383": {"$update": {"dna_sequence": {"$update": {"accession": "AM932669.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA21"}}, "156": {"$update": {"ARO_description": "AAC(6')-Iaf is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"672": {"$update": {"dna_sequence": {"$update": {"accession": "AB462903.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iaf"}}, "159": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"412": {"$update": {"dna_sequence": {"$update": {"accession": "DQ823382.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vgaALC"}}, "158": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"204": {"$update": {"dna_sequence": {"$update": {"accession": "D16099.1"}}}}}}}}, "ARO_category": {"$update": {"37697": {"$update": {"category_aro_description": "Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides."}}}}}, "$insert": {"CARD_short_name": "myrA"}}, "2430": {"$insert": {"CARD_short_name": "hp1181"}}, "2436": {"$update": {"ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "Ddl"}}, "2435": {"$insert": {"CARD_short_name": "lmrP"}}, "2434": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}}, "$insert": {"CARD_short_name": "Kpne_OmpK36"}}, "4922": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-596"}}, "4637": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-24"}}, "4518": {"$insert": {"CARD_short_name": "CTX-M-189"}}, "4519": {"$insert": {"CARD_short_name": "CTX-M-190"}}, "4512": {"$insert": {"CARD_short_name": "CTX-M-183"}}, "4513": {"$insert": {"CARD_short_name": "CTX-M-184"}}, "4510": {"$insert": {"CARD_short_name": "CTX-M-181"}}, "4511": {"$insert": {"CARD_short_name": "CTX-M-182"}}, "4516": {"$insert": {"CARD_short_name": "CTX-M-187"}}, "4517": {"$insert": {"CARD_short_name": "CTX-M-188"}}, "4514": {"$insert": {"CARD_short_name": "CTX-M-185"}}, "4515": {"$insert": {"CARD_short_name": "CTX-M-186"}}, "5289": {"$insert": {"CARD_short_name": "PDC-151"}}, "5288": {"$insert": {"CARD_short_name": "PDC-150"}}, "2724": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "MuxABC-OpmB"}}, "2720": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5199": {"$update": {"protein_sequence": {"$update": {"accession": "AAG05914.1"}}}}}}}}}, "$insert": {"CARD_short_name": "MuxC"}}, "5281": {"$insert": {"CARD_short_name": "PDC-144"}}, "5280": {"$insert": {"CARD_short_name": "PDC-143"}}, "5283": {"$insert": {"CARD_short_name": "PDC-146"}}, "5282": {"$insert": {"CARD_short_name": "PDC-145"}}, "5285": {"$insert": {"CARD_short_name": "PDC-148"}}, "5284": {"$insert": {"CARD_short_name": "PDC-147"}}, "2729": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "MexJK-OprM"}}, "5286": {"$insert": {"CARD_short_name": "PDC-149"}}, "280": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1588": {"$update": {"dna_sequence": {"$update": {"accession": "AY005110.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-11"}}, "4367": {"$insert": {"CARD_short_name": "AXC-5"}}, "5049": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-167"}}, "1949": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1579": {"$update": {"dna_sequence": {"$update": {"accession": "AY227052.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cphA6"}}, "1525": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1798": {"$update": {"dna_sequence": {"$update": {"accession": "EF136377.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-160"}}, "1942": {"$update": {"model_name": "BJP-1"}, "$insert": {"CARD_short_name": "BJP-1"}}, "1943": {"$update": {"ARO_description": "Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid, resulting in resistance.", "model_sequences": {"$update": {"sequence": {"$update": {"2084": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Mtub_kasA_INH"}}, "1940": {"$update": {"ARO_description": "QnrB30 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii.", "model_sequences": {"$update": {"sequence": {"$update": {"327": {"$update": {"dna_sequence": {"$update": {"accession": "HM439650.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB30"}}, "1941": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"994": {"$update": {"dna_sequence": {"$update": {"accession": "AM941844.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-98"}}, "1946": {"$update": {"ARO_description": "CTX-M-10 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1995": {"$update": {"dna_sequence": {"$update": {"accession": "AY598759.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-10"}}, "1947": {"$insert": {"CARD_short_name": "CTX-M-160"}}, "3256": {"$update": {"ARO_description": "A dihydrofolate reductase and trimethoprim resistance gene identified from porcine isolates of Esherichia coli."}, "$insert": {"CARD_short_name": "dfrA9"}}, "1945": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1236": {"$update": {"dna_sequence": {"$update": {"accession": "AY288915.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-50"}}, "818": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1634": {"$update": {"dna_sequence": {"$update": {"accession": "JQ388884.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-141"}}, "819": {"$update": {"ARO_description": "CTX-M-68 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1274": {"$update": {"dna_sequence": {"$update": {"accession": "EU177100.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-68"}}, "1527": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1316": {"$update": {"dna_sequence": {"$update": {"accession": "AY289548.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-51"}}, "810": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mecC"}}, "811": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-26"}}, "812": {"$update": {"ARO_description": "CMY-10 is a beta-lactamase found in Klebsiella aerogenes.", "model_sequences": {"$update": {"sequence": {"$update": {"1114": {"$update": {"dna_sequence": {"$update": {"accession": "AF357597.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-10"}}, "813": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1373": {"$update": {"dna_sequence": {"$update": {"accession": "FR865168.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-216"}}, "814": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1795": {"$update": {"dna_sequence": {"$update": {"accession": "AY589494.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-113"}}, "815": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1110": {"$update": {"dna_sequence": {"$update": {"accession": "AF090141.1"}}}}}}}}, "model_name": "GOB-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-1"}}, "816": {"$update": {"ARO_description": "OXA-3 is a beta-lactamase found in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1051": {"$update": {"dna_sequence": {"$update": {"accession": "L07945.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-3"}}, "817": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1902": {"$update": {"dna_sequence": {"$update": {"accession": "KM211691.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-158"}}, "2859": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-80"}}, "1991": {"$update": {"ARO_description": "otrC is a tetracycline resistance efflux pump found in Streptomyces rimosus.", "model_sequences": {"$update": {"sequence": {"$update": {"421": {"$update": {"dna_sequence": {"$update": {"accession": "AY509111.1"}}}}}}}}}, "$insert": {"CARD_short_name": "otrC"}}, "3495": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-411"}}, "1522": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1709": {"$update": {"dna_sequence": {"$update": {"accession": "HQ875573.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-38"}}, "1990": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"905": {"$update": {"dna_sequence": {"$update": {"accession": "KJ207203.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-82"}}, "2851": {"$update": {"ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Ecol_gyrA_TRC"}}, "2850": {"$update": {"ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Sent_gyrA_TRC"}}, "2853": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-74"}}, "1523": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"335": {"$update": {"dna_sequence": {"$update": {"accession": "U57969.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MexD"}}, "2855": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-76"}}, "1621": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"834": {"$update": {"dna_sequence": {"$update": {"accession": "AF547625.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-45"}}, "2857": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-78"}}, "2856": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-77"}}, "5461": {"$insert": {"CARD_short_name": "PDC-331"}}, "5460": {"$insert": {"CARD_short_name": "PDC-330"}}, "5463": {"$insert": {"CARD_short_name": "PDC-333"}}, "5462": {"$insert": {"CARD_short_name": "PDC-332"}}, "1494": {"$update": {"ARO_description": "LAT-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1988": {"$update": {"dna_sequence": {"$update": {"accession": "X78117.1"}}}}}}}}}, "$insert": {"CARD_short_name": "LAT-1"}}, "5464": {"$insert": {"CARD_short_name": "PDC-334"}}, "5467": {"$insert": {"CARD_short_name": "PDC-338"}}, "5466": {"$insert": {"CARD_short_name": "PDC-336"}}, "1498": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1731": {"$update": {"dna_sequence": {"$update": {"accession": "AY261375.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cphA8"}}, "1499": {"$update": {"ARO_description": "VEB-6 is a beta-lactamase found in Proteus mirabilis.", "ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-6"}}, "3339": {"$insert": {"CARD_short_name": "dfrA15b"}}, "3338": {"$update": {"ARO_description": "AAC(6')-Iag is an aminoglycoside acetyltransferase encoded by integrons in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "AAC(6')-Iag"}}, "1395": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"54": {"$update": {"dna_sequence": {"$update": {"accession": "U75641.1"}}}}}}}}, "model_name": "Neisseria gonorrhoeae porin PIB (por)", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Ngon_porin"}}, "1994": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"626": {"$update": {"dna_sequence": {"$update": {"accession": "AJ223970.1"}}}}}}}}, "ARO_category": {"$update": {"37621": {"$update": {"category_aro_description": "Produced by Streptomyces bikiniensis."}}}}}, "$insert": {"CARD_short_name": "gimA"}}, "1700": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1018": {"$update": {"dna_sequence": {"$update": {"accession": "KJ207206.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-28"}}, "1701": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"274": {"$update": {"dna_sequence": {"$update": {"accession": "AY487229.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Erm(39)"}}, "1702": {"$update": {"ARO_description": "MIR-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8186": {"dna_sequence": {"partial": "0", "sequence": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTTCGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "fmax": "2073", "accession": "M37839.2", "fmin": "927", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAD22636.1", "sequence": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHFAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ"}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-1"}}, "5264": {"$insert": {"CARD_short_name": "PDC-128"}}, "1704": {"$update": {"ARO_description": "CMY-57 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1283": {"$update": {"dna_sequence": {"$update": {"accession": "HQ285243.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-57"}}, "1705": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1230": {"$update": {"dna_sequence": {"$update": {"accession": "AB372881.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-111"}}, "1706": {"$update": {"ARO_description": "OXA-142 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1204": {"$update": {"dna_sequence": {"$update": {"accession": "EU358785.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-142"}}, "1707": {"$update": {"ARO_description": "QnrB4 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8184": {"dna_sequence": {"partial": "0", "sequence": "ATGACTCTGGCGTTAGTTGGCGAAAAAATTGACAGAAACAGGTTCACCGGTGAAAAAGTTGAAAATAGCACATTTTTCAACTGTGATTTTTCGGGTGCCGACCTTAGCGGCACTGAATTTATTGGCTGCCAGTTTTATGATCGAGAAAGTCAGAAAGGATGTAATTTTAGTCGCGCTAACCTGAAAGATGCCATTTTCAAAAGTTGTGATCTCTCCATGGCTGATTTCAGGAATATCAATGCGCTGGGAATCGAAATTCGCCACTGCCGGGCACAAGGGTCAGATTTTCGCGGCGCAAGTTTTATGAATATGATCACCACCCGCACCTGGTTTTGTAGCGCCTATATCACCAATACCAACTTAAGCTACGCCAACTTTTCAAAAGTCGTACTGGAAAAGTGCGAGCTGTGGGAAAACCGCTGGATGGGTACTCAGGTGCTGGGCGCAACGTTCAGTGGATCAGACCTCTCTGGCGGCGAGTTTTCATCCTTCGACTGGCGAGCAGCAAACGTTACGCACTGTGATTTGACCAATTCGGAACTGGGCGATTTAGATATCCGCGGGGTTGATTTGCAAGGCGTCAAACTGGACAGCTACCAGGCATCGTTGCTCCTGGAACGTCTTGGTATCGCTGTCATGGGTTAA", "fmax": "648", "accession": "DQ303921.2", "fmin": "3", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ABC17630.3", "sequence": "MTLALVGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRANLKDAIFKSCDLSMADFRNINALGIEIRHCRAQGSDFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGTQVLGATFSGSDLSGGEFSSFDWRAANVTHCDLTNSELGDLDIRGVDLQGVKLDSYQASLLLERLGIAVMG"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB4"}}, "1708": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"374": {"$update": {"dna_sequence": {"$update": {"accession": "AJ514254.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet36"}}, "425": {"$update": {"ARO_description": "TEM-182 is a beta-lactamase found in clinical isolates of H. parainfluenzae.", "model_sequences": {"$update": {"sequence": {"$update": {"1570": {"$update": {"dna_sequence": {"$update": {"accession": "HQ317449.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-182"}}, "1996": {"$update": {"ARO_description": "Also known as vanXM, is a vanX variant found in the vanM gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"717": {"$update": {"dna_sequence": {"$update": {"accession": "FJ349556.1"}}}}}}}}, "model_name": "vanX gene in vanM cluster", "ARO_name": "vanX gene in vanM cluster"}, "$insert": {"CARD_short_name": "vanX_in_vanM_cl"}}, "4572": {"$insert": {"CARD_short_name": "CTX-M-244"}}, "5269": {"$insert": {"CARD_short_name": "PDC-132"}}, "424": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1392": {"$update": {"dna_sequence": {"$update": {"accession": "AF467947.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-36"}}, "4573": {"$insert": {"CARD_short_name": "CTX-M-73"}}, "1391": {"$update": {"ARO_description": "CTX-M-92 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1967": {"$update": {"dna_sequence": {"$update": {"accession": "GU127598.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-92"}}, "3658": {"$update": {"ARO_description": "New Delhi class B metallo-beta-lactamase-16 variant of NDM-1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-16"}}, "1390": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "arlR"}}, "5188": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-891"}}, "3659": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase and NDM-1 variant.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-18"}}, "1128": {"$update": {"ARO_description": "OXA-23 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"885": {"$update": {"dna_sequence": {"$update": {"accession": "AY795964.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-23"}}, "1129": {"$update": {"ARO_description": "CMY-19 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"761": {"$update": {"dna_sequence": {"$update": {"accession": "AB194410.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-19"}}, "5189": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-892"}}, "4576": {"$insert": {"CARD_short_name": "DHA-23"}}, "1120": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2107": {"$update": {"dna_sequence": {"$update": {"accession": "KM103296.1"}}}}}}}}}, "$insert": {"CARD_short_name": "IMI-7"}}, "1121": {"$update": {"ARO_description": "APH(3')-VIa is a plasmid-encoded aminoglycoside phosphotransferase in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"368": {"$update": {"dna_sequence": {"$update": {"accession": "X07753.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-VIa"}}, "1122": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1293": {"$update": {"dna_sequence": {"$update": {"accession": "HM570036.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-180"}}, "1123": {"$update": {"ARO_description": "FOX-8 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1434": {"$update": {"dna_sequence": {"$update": {"accession": "HM565917.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-8"}}, "1124": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1883": {"$update": {"dna_sequence": {"$update": {"accession": "JN227084.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-186"}}, "1125": {"$update": {"ARO_description": "OKP-B-11 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"877": {"$update": {"dna_sequence": {"$update": {"accession": "AM051161.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-11"}}, "1126": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1604": {"$update": {"dna_sequence": {"$update": {"accession": "JQ396378.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-184"}}, "1127": {"$update": {"ARO_description": "CTX-M-64 is a beta-lactamase found in Shigella sonnei.", "model_sequences": {"$update": {"sequence": {"8154": {"dna_sequence": {"partial": "0", "sequence": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCAAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATGACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA", "fmax": "1101", "accession": "AB284167.2", "fmin": "225", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella sonnei", "NCBI_taxonomy_id": "624", "NCBI_taxonomy_cvterm_id": "36790"}, "protein_sequence": {"accession": "BAF63422.1", "sequence": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-64"}}, "4578": {"$insert": {"CARD_short_name": "DHA-25"}}, "5096": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-788"}}, "5437": {"$insert": {"CARD_short_name": "PDC-307"}}, "3024": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-24"}}, "3651": {"$insert": {"CARD_short_name": "Mtub_16S_CAP"}}, "524": {"$update": {"ARO_description": "dfrA25 is an integron-encoded dihydrofolate reductase found in Salmonella agona.", "model_sequences": {"$update": {"sequence": {"$update": {"49": {"$update": {"dna_sequence": {"$update": {"accession": "DQ267940.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA25"}}, "525": {"$update": {"ARO_description": "CMY-13 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8156": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCTCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCATTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACTGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCACGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "fmax": "4786", "accession": "AY339625.2", "fmin": "3640", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAQ16660.2", "sequence": "MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ"}}}}}}, "$insert": {"CARD_short_name": "CMY-13"}}, "526": {"$update": {"ARO_description": "ACT-2 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1812": {"$update": {"dna_sequence": {"$update": {"accession": "AM076977.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-2"}}, "527": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1561": {"$update": {"dna_sequence": {"$update": {"accession": "AY079099.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-38"}}, "1018": {"$update": {"ARO_description": "APH(3')-IIc is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia.", "model_sequences": {"$update": {"sequence": {"$update": {"194": {"$update": {"dna_sequence": {"$update": {"accession": "HQ424460.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-IIc"}}, "521": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4559": {"$update": {"dna_sequence": {"$update": {"accession": "KF986254.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-386"}}, "522": {"$update": {"ARO_description": "floR is a plasmid or chromosome-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 and Vibrio cholerae.", "model_sequences": {"$update": {"sequence": {"8160": {"dna_sequence": {"partial": "0", "sequence": "ATGACCACCACACGCCCCGCGTGGGCCTATACGCTGCCGGCAGCACTGCTGCTGATGGCTCCTTTCGACATCCTCGCTTCACTGGCGATGGATATTTATCTCCCTGTCGTTCCAGCGATGCCCGGCATCCTGAACACGACGCCCGCTATGATCCAACTCACGTTGAGCCTCTATATGGTGATGCTCGGCGTGGGCCAGGTGATTTTTGGTCCGCTCTCAGACAGAATCGGGCGACGGCCAATTCTACTTGCGGGCGCAACGGCTTTCGTCATTGCGTCTCTGGGAGCAGCTTGGTCTTCAACTGCACCGGCCTTTGTCGCTTTCCGTCTACTTCAAGCAGTGGGCGCGTCGGCCATGCTGGTGGCGACGTTCGCGACGGTTCGCGACGTTTATGCCAACCGTCCTGAGGGTGTCGTCATCTACGGCCTTTTCAGTTCGGTGCTGGCGTTCGTGCCTGCGCTCGGCCCTATCGCCGGAGCATTGATCGGCGAGTTCTTGGGATGGCAGGCGATATTCATTACTTTGGCTATACTGGCGATGCTCGCACTCCTAAATGCGGGTTTCAGGTGGCACGAAACCCGCCCTCTGGATCAAGTCAAGACGCGCCGATCTGTCTTGCCGATCTTCGCGAGTCCGGCTTTTTGGGTTTACACTGTCGGCTTTAGCGCCGGTATGGGCACCTTCTTCGTCTTCTTCTCGACGGCTCCCCGTGTGCTCATAGGCCAAGCGGAATATTCCGAGATCGGATTCAGCTTTGCCTTCGCCACTGTCGCGCTTGTAATGATCGTGACAACCCGTTTCGCGAAGTCCTTTGTCGCCAGATGGGGCATCGCAGGATGCGTGGCGCGTGGGATGGCGTTGCTTGTTTGCGGAGCGGTCCTGTTGGGGATCGGCGAACTTTACGGCTCGCCGTCATTCCTCACCTTCATCCTACCGATGTGGGTTGTCGCGGTCGGTATTGTCTTCACGGTGTCCGTTACCGCGAACGGCGCTTTGGCAGAGTTCGACGACATCGCGGGATCAGCGGTCGCGTTCTACTTCTGCGTTCAAAGCCTGATAGTCAGCATTGTCGGGACATTGGCGGTGGCACTTTTAAACGGTGACACAGCGTGGCCCGTGATCTGTTACGCCACGGCGATGGCGGTACTGGTTTCGTTGGGGCTGGTGCTCCTTCGGCTCCGTGGGGCTGCCACCGAGAAGTCGCCAGTCGTCTAA", "fmax": "4522", "accession": "AF231986.2", "fmin": "3307", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAG16656.1", "sequence": "MTTTRPAWAYTLPAALLLMAPFDILASLAMDIYLPVVPAMPGILNTTPAMIQLTLSLYMVMLGVGQVIFGPLSDRIGRRPILLAGATAFVIASLGAAWSSTAPAFVAFRLLQAVGASAMLVATFATVRDVYANRPEGVVIYGLFSSVLAFVPALGPIAGALIGEFLGWQAIFITLAILAMLALLNAGFRWHETRPLDQVKTRRSVLPIFASPAFWVYTVGFSAGMGTFFVFFSTAPRVLIGQAEYSEIGFSFAFATVALVMIVTTRFAKSFVARWGIAGCVARGMALLVCGAVLLGIGELYGSPSFLTFILPMWVVAVGIVFTVSVTANGALAEFDDIAGSAVAFYFCVQSLIVSIVGTLAVALLNGDTAWPVICYATAMAVLVSLGLVLLRLRGAATEKSPVV"}}}}}}, "$insert": {"CARD_short_name": "floR"}}, "523": {"$update": {"ARO_description": "OXA-75 is a beta-lactamase found in A. baumannii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-75"}}, "1014": {"$update": {"model_sequences": {"$update": {"sequence": {"8205": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCGCCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCGTGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AF208796.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAF37209.2", "sequence": "MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-25"}}, "1015": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "evgA"}}, "1016": {"$update": {"ARO_description": "OXA-255 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"8157": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAAATTTATACTTCCTATCTTCAGCATTTCTACTCTACTTTCTCTCAGTGCATGCTCAACTATTCAAAATAAATTTGAAAAAACTTCTGATATTTCTGATCAGCAACATGAAAAAGCCATTAAAAGCTATTTTGATGAAGCTCAAACACAAGGTGTAATAATTATTAAAGAGGGAAAGAATATTAGAATCTATGGTAATAACCTGGTACGAGCACATACAGAATATGTCCCTGCGTCAACATTTAAGATGCTAAATGCCTTAATTGGATTAGAAAATCATAAAGCTACAACAACTGAGATTTTCAAATGGGATGGTAAAAAAAGATCTTATCCTATGTGGGAAAAAGATATGACTTTAGGTGATGCCATGGCACTTTCAGCAGTTCCTGTATATCAAGAACTTGCAAGACGGACTGGCTTAGATCTAATGCAAAAAGAAGTTAAACGGGTTGGTTTTGGTAATATGAGCATCGGGACACAAGTTAATAACTTCTGGTTAGTTGGCCCCCTCAAGATTACACCAATACAAGAGGCTAATTTTGCCGATGATCTTGCGAATAATCGATTACCCTTTAAATTAGAAACTCAAGAAGAAGTAAAAAAAATGCTTCTGATTAAAGAAGTCAATGGTAGTAAAATTTATGCGAAAAGTGGATGGGGAATGGATGTGACCCCTCAAGTAGGTTGGTTAACAGGTTGGGTAGAAAAATCTAATGGCGAAAAAGTTCCCTTTTCTCTAAACCTAGAAATGAAGCAAGGAATGTCTGGTTCTATTCGTAATGAAATTACTTATAAATCATTAGAAAATTTAGGGATTATATAA", "fmax": "1496", "accession": "KC479325.2", "fmin": "668", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter pittii", "NCBI_taxonomy_id": "48296", "NCBI_taxonomy_cvterm_id": "36787"}, "protein_sequence": {"accession": "AGK07369.1", "sequence": "MKKFILPIFSISTLLSLSACSTIQNKFEKTSDISDQQHEKAIKSYFDEAQTQGVIIIKEGKNIRIYGNNLVRAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEKDMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMSIGTQVNNFWLVGPLKITPIQEANFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVTPQVGWLTGWVEKSNGEKVPFSLNLEMKQGMSGSIRNEITYKSLENLGII"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-255"}}, "1017": {"$update": {"ARO_description": "CTX-M-86 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"1413": {"$update": {"dna_sequence": {"$update": {"accession": "FJ214369.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-86"}}, "1010": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1001": {"$update": {"dna_sequence": {"$update": {"accession": "KF240808.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-209"}}, "529": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2023": {"$update": {"dna_sequence": {"$update": {"accession": "KM233164.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-185"}}, "1012": {"$update": {"model_sequences": {"$update": {"sequence": {"8232": {"dna_sequence": {"partial": "0", "sequence": "ATGTCACTGTATCGCCGTCTAGTTCTGCTGTCTTGTCTCTCATGGCCGCTGGCTGGCTTTTCTGCCACCGCGCTGACCAACCTCGTCGCGGAACCATTCGCTAAACTCGAACAGGACTTTGGCGGCTCCATCGGTGTGTACGCGATGGATACCGGCTCAGGCGCAACTGTAAGTTACCGCGCTGAGGAGCGCTTCCCACTGTGCAGCTCATTCAAGGGCTTTCTTGCTGCCGCTGTGCTGGCTCGCAGCCAGCAGCAGGCCGGCTTGCTGGACACACCCATCCGTTACGGCAAAAATGCGCTGGTTCGGTGGTCACCCATCTCGGAAAAATATCTGACAACAGGCATGACGGTGGCGGAGCTGTCCGCGGCCGCCGTGCAATACAGTGATAACGCCGCCGCCAATTTGTTGCTGAAGGAGTTGGGCGGCCCGGCCGGGCTGACGGCCTTCATGCGCTCTATCGGCGATACCACGTTCCGTCTGGACCGCTGGGAGCTGGAGCTGAACTCCGCCATCCCAGGCGATGCGCGCGATACCTCATCGCCGCGCGCCGTGACGGAAAGCTTACAAAAACTGACACTGGGCTCTGCACTGGCTGCGCCGCAGCGGCAGCAGTTTGTTGATTGGCTAAAGGGAAACACGACCGGCAACCACCGCATCCGCGCGGCGGTGCCGGCAGACTGGGCAGTCGGAGACAAAACCGGAACCTGCGGAGTGTATGGCACGGCAAATGACTATGCCGTCGTCTGGCCCACTGGGCGCGCACCTATTGTGTTGGCCGTCTACACCCGGGCGCCTAACAAGGATGACAAGCACAGCGAGGCCGTCATCGCCGCTGCGGCTAGACTCGCGCTCGAGGGATTGGGCGTCAACGGGCAGTAA", "fmax": "3041", "accession": "EU400222.2", "fmin": "2159", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "ABY91240.1", "sequence": "MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-5"}}, "1013": {"$update": {"ARO_description": "APH(2'')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in Enterococcus gallinarum.", "model_sequences": {"$update": {"sequence": {"$update": {"181": {"$update": {"dna_sequence": {"$update": {"accession": "U51479.1"}}}}}}}}, "ARO_category": {"$update": {"36267": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''."}}}}}, "$insert": {"CARD_short_name": "APH(2'')-IIIa"}}, "1234": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1348": {"$update": {"dna_sequence": {"$update": {"accession": "KM087862.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-13"}}, "1235": {"$insert": {"CARD_short_name": "AAC(6')-Ib'"}}, "1236": {"$update": {"ARO_description": "CMY-53 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"958": {"$update": {"dna_sequence": {"$update": {"accession": "HQ336940.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-53"}}, "1237": {"$insert": {"CARD_short_name": "Mtub_rpoB_RIF"}}, "1230": {"$update": {"ARO_description": "CTX-M-33 is a beta-lactamase found in Salmonella enterica."}, "$insert": {"CARD_short_name": "CTX-M-33"}}, "1231": {"$insert": {"CARD_short_name": "mel"}}, "1232": {"$insert": {"CARD_short_name": "cmeR"}}, "1233": {"$insert": {"CARD_short_name": "tet32"}}, "4196": {"$insert": {"CARD_short_name": "ADC-123"}}, "4197": {"$insert": {"CARD_short_name": "ADC-125"}}, "4194": {"$insert": {"CARD_short_name": "ADC-121"}}, "4195": {"$insert": {"CARD_short_name": "ADC-122"}}, "1238": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1535": {"$update": {"dna_sequence": {"$update": {"accession": "KM087865.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-397"}}, "1239": {"$update": {"model_sequences": {"$update": {"sequence": {"8204": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCAGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "886", "accession": "AM176556.2", "fmin": "25", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47136.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGSPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-81"}}, "4190": {"$insert": {"CARD_short_name": "ADC-116"}}, "4191": {"$insert": {"CARD_short_name": "ADC-117"}}, "5670": {"$insert": {"CARD_short_name": "TER-1"}}, "5671": {"$insert": {"CARD_short_name": "TER-2"}}, "5672": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8047": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "TTU-1"}}, "5673": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-10"}}, "4358": {"$insert": {"CARD_short_name": "ALG11-1"}}, "5675": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-12"}}, "5676": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-13"}}, "5677": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-14"}}, "4354": {"$insert": {"CARD_short_name": "ADC-98"}}, "4355": {"$insert": {"CARD_short_name": "ADC-99"}}, "4356": {"$update": {"ARO_category": {"$update": {"43848": {"$update": {"category_aro_description": "AFM beta-lactamases are class B1 beta-lactamases found in proteobacteria like Pseudomonas aeruginosa."}}}}}, "$insert": {"CARD_short_name": "AFM-1"}}, "4357": {"$update": {"ARO_category": {"$update": {"43848": {"$update": {"category_aro_description": "AFM beta-lactamases are class B1 beta-lactamases found in proteobacteria like Pseudomonas aeruginosa."}}}}}, "$insert": {"CARD_short_name": "AFM-2"}}, "4350": {"$insert": {"CARD_short_name": "ADC-94"}}, "4351": {"$insert": {"CARD_short_name": "ADC-95"}}, "4352": {"$insert": {"CARD_short_name": "ADC-96"}}, "4353": {"$insert": {"CARD_short_name": "ADC-97"}}, "833": {"$update": {"ARO_description": "CfxA5 beta-lactamase is a class A beta-lactamase found in Bacteroides distasonis.", "model_sequences": {"$update": {"sequence": {"$update": {"1669": {"$update": {"dna_sequence": {"$update": {"accession": "AY769934.1"}}}}}}}}, "ARO_category": {"$update": {"39434": {"$update": {"category_aro_description": "CfxA beta-lactamases are class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "CfxA5"}}, "1564": {"$update": {"ARO_description": "QnrB16 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"349": {"$update": {"dna_sequence": {"$update": {"accession": "EU136183.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB16"}}, "_version": "3.2.0", "4901": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-575"}}, "438": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"936": {"$update": {"dna_sequence": {"$update": {"accession": "AY165025.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-6"}}, "439": {"$update": {"model_sequences": {"$update": {"sequence": {"8139": {"dna_sequence": {"partial": "1", "sequence": "AAGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM176558.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47138.2", "sequence": "KRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-83"}}, "436": {"$update": {"ARO_description": "OXY-4-1 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1939": {"$update": {"dna_sequence": {"$update": {"accession": "AY077481.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-4-1"}}, "437": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1317": {"$update": {"dna_sequence": {"$update": {"accession": "DQ174308.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-69"}}, "434": {"$update": {"ARO_description": "LEN-16 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1347": {"$update": {"dna_sequence": {"$update": {"accession": "AY743416.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-16"}}, "435": {"$update": {"ARO_description": "OKP-A-9 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1919": {"$update": {"dna_sequence": {"$update": {"accession": "AM051148.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-9"}}, "433": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"861": {"$update": {"dna_sequence": {"$update": {"accession": "KJ207208.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-25"}}, "430": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"981": {"$update": {"dna_sequence": {"$update": {"accession": "DQ348075.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-87"}}, "431": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2097": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "ARO_name": "Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline"}, "$insert": {"CARD_short_name": "Ecol_MarR_MULT"}}, "4902": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ROB-3"}}, "3808": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ROB-2"}}, "3805": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "ParS"}}, "3804": {"$insert": {"CARD_short_name": "cprS"}}, "3807": {"$insert": {"CARD_short_name": "rsmA"}}, "3806": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "ParR"}}, "3801": {"$update": {"ARO_description": "A novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin."}, "$insert": {"CARD_short_name": "AAC(3)-IVb"}}, "3800": {"$update": {"ARO_description": "A class D OXA-like beta-lactamase described in the emerging pathogen Cupriavidus gilardii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-837"}}, "3803": {"$insert": {"CARD_short_name": "cprR"}}, "3802": {"$update": {"ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "ANT(3'')-Ib"}}, "4907": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-581"}}, "5425": {"$insert": {"CARD_short_name": "PDC-295"}}, "473": {"$update": {"ARO_description": "mphF is a macrolide phosphotransferase and resistance gene identified on the IncP plasmid pRSB111."}, "$insert": {"CARD_short_name": "mphF"}}, "559": {"$update": {"ARO_description": "Also known as vanXY, is a vanXY variant found in the vanE gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"106": {"$update": {"dna_sequence": {"$update": {"accession": "FJ872411.1"}}}}}}}}, "model_name": "vanXY gene in vanE cluster", "ARO_name": "vanXY gene in vanE cluster"}, "$insert": {"CARD_short_name": "vanXY_in_vanE"}}, "4849": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7224": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-514"}}, "4670": {"$insert": {"CARD_short_name": "IMI-16"}}, "558": {"$update": {"ARO_description": "qacB is a subunit of the qac multidrug efflux pump.", "model_sequences": {"$update": {"sequence": {"$update": {"307": {"$update": {"dna_sequence": {"$update": {"accession": "AF535087.1"}}}}}}}}}, "$insert": {"CARD_short_name": "qacB"}}, "5708": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-59"}}, "5709": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-60"}}, "5704": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-55"}}, "5705": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-56"}}, "5706": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-57"}}, "5707": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-36"}}, "4618": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-137"}}, "239": {"$update": {"ARO_description": "OXA-83 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1937": {"$update": {"dna_sequence": {"$update": {"accession": "DQ309277.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-19"}}, "237": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Cmen_BlaB"}}, "230": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"892": {"$update": {"dna_sequence": {"$update": {"accession": "KM433671.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-422"}}, "231": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1046": {"$update": {"dna_sequence": {"$update": {"accession": "HM113564.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-178"}}, "232": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1808": {"$update": {"dna_sequence": {"$update": {"accession": "AJ548797.1"}}}}}}}}}, "$insert": {"CARD_short_name": "imiH"}}, "233": {"$update": {"ARO_description": "LEN-21 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8266": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCAGGGGTCGAACAACTGGTTCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM850911.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12349.2", "sequence": "MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGVEQLVRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-21"}}, "3953": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-219"}}, "4680": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-23"}}, "2228": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3429": {"$update": {"dna_sequence": {"$update": {"accession": "KP109677.1"}}, "protein_sequence": {"$update": {"accession": "AJP77059.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PEDO-1"}}, "2229": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3428": {"$update": {"dna_sequence": {"$update": {"accession": "KP109678.1"}}, "protein_sequence": {"$update": {"accession": "AJP77071.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PEDO-2"}}, "2227": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3430": {"$update": {"dna_sequence": {"$update": {"accession": "KT818596.1"}}, "protein_sequence": {"$update": {"accession": "ALU64000.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VCC-1"}}, "2224": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Paer_oprD_IPM"}}, "5149": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-852"}}, "2222": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-1b"}}, "2223": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}, "model_name": "MexZ"}, "$insert": {"CARD_short_name": "MexZ"}}, "1": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1619": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666067.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PDC-4"}}, "4880": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7255": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-551"}}, "2704": {"$update": {"ARO_description": "The MexEF\u2013OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin.", "model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "Paer_MexT_MULT"}}, "5255": {"$insert": {"CARD_short_name": "PDC-12"}}, "4882": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7257": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-553"}}, "146": {"$update": {"ARO_description": "OXA-98 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1769": {"$update": {"dna_sequence": {"$update": {"accession": "AM279652.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-98"}}, "5458": {"$insert": {"CARD_short_name": "PDC-329"}}, "144": {"$update": {"ARO_description": "IMP-12 is a beta-lactamase found in Pseudomonas putida.", "model_sequences": {"$update": {"sequence": {"$update": {"1824": {"$update": {"dna_sequence": {"$update": {"accession": "AJ420864.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-12"}}, "145": {"$update": {"ARO_description": "OXA-229 is a beta-lactamase found in A. bereziniae.", "model_sequences": {"$update": {"sequence": {"$update": {"804": {"$update": {"dna_sequence": {"$update": {"accession": "JQ422052.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-229"}}, "142": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"587": {"$update": {"dna_sequence": {"$update": {"accession": "L06940.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(E)"}}, "143": {"$insert": {"CARD_short_name": "cphA7"}}, "140": {"$update": {"ARO_description": "AAC(6')-IIb is an integron-encoded aminoglycoside acetyltransferase in P. fluorescens.", "model_sequences": {"$update": {"sequence": {"$update": {"497": {"$update": {"dna_sequence": {"$update": {"accession": "L06163.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-IIb"}}, "5459": {"$insert": {"CARD_short_name": "PDC-33"}}, "5069": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-92"}}, "149": {"$update": {"ARO_description": "aadA12 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli, Yersinia enterocolitica and S. enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"57": {"$update": {"dna_sequence": {"$update": {"accession": "FJ381668.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA12"}}, "4505": {"$insert": {"CARD_short_name": "CTX-M-176"}}, "4504": {"$insert": {"CARD_short_name": "CTX-M-175"}}, "4507": {"$insert": {"CARD_short_name": "CTX-M-178"}}, "4506": {"$insert": {"CARD_short_name": "CTX-M-177"}}, "4501": {"$insert": {"CARD_short_name": "CTX-M-172"}}, "4500": {"$insert": {"CARD_short_name": "CTX-M-171"}}, "4503": {"$insert": {"CARD_short_name": "CTX-M-174"}}, "4502": {"$insert": {"CARD_short_name": "CTX-M-173"}}, "4874": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-545"}}, "1995": {"$update": {"ARO_description": "AAC(6')-Iz is a chromosomal-encoded aminoglycoside acetyltransferase in S. maltophilia.", "model_sequences": {"$update": {"sequence": {"$update": {"205": {"$update": {"dna_sequence": {"$update": {"accession": "AF140221.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iz"}}, "2797": {"$insert": {"CARD_short_name": "AxyX"}}, "4509": {"$insert": {"CARD_short_name": "CTX-M-180"}}, "4508": {"$insert": {"CARD_short_name": "CTX-M-179"}}, "5352": {"$insert": {"CARD_short_name": "PDC-215"}}, "3401": {"$insert": {"CARD_short_name": "Tet(X3)"}}, "2088": {"$update": {"ARO_description": "Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to streptomycin.", "model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin"}, "$insert": {"CARD_short_name": "Msme_16rrsB_STR"}}, "5351": {"$insert": {"CARD_short_name": "PDC-214"}}, "3400": {"$update": {"ARO_description": "vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci.", "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "Scoh_vga(E)"}}, "2083": {"$update": {"ARO_description": "Point mutation in Mycoplasma hominis parC resulting in fluoroquinolone resistance.", "model_name": "Mycoplasma hominis parC conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Mhom_23S_FLO"}}, "2080": {"$update": {"ARO_description": "Point mutations in the 3' major domain of the rrsH 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"3228": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. 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K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin"}, "$insert": {"CARD_short_name": "Ecol_16S_SPT"}}, "3342": {"$update": {"ARO_description": "A dihydrofolate reductase that confers resistance to trimethoprim.", "model_sequences": {"$update": {"sequence": {"8345": {"dna_sequence": {"partial": "0", "sequence": "ATGACTAAACAAGCAATATTTGCCGTAGCCGAGAACCTAGCCTTCGGGCTAGGTGGGGGTCTCCCTTGGGATACGCTGAAAGACGACTTACAATTCTTTAAGAGGCTAACTGAAGGGACTGACTTAGTAATGGGAGCCTCCACGTACAGAACGCTGCCATTGTTACCAACCAATAACAGACAGTTTATTGTGGTAAGCAATACTGAGGAGCCTAGCCTTAATGTTCATGTGGTATCTCCAGAACACTTCAAGGCTTTCCTTAGCAAAACTTCCAGAAACCTTACTATTATCGGGGGCAGCTCGTTACTAACGGTAGATATATTATCAAAAATGGATAAGATAATTATGACTACGGTGTATGGAAGTTTTGATGCAGATGTATACTTACCTACTGAAGTAGTAAGTTATGTTACTGGCAAAGCTTCAAACGCCACATTATTTAATAACTCGGACGCAAAGATGGCAGTTTATTATGGATAA", "fmax": "6095", "accession": "AY162283.2", "fmin": "5615", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Citrobacter freundii", "NCBI_taxonomy_id": "546", "NCBI_taxonomy_cvterm_id": "36915"}, "protein_sequence": {"accession": "AAN85115.1", "sequence": "MTKQAIFAVAENLAFGLGGGLPWDTLKDDLQFFKRLTEGTDLVMGASTYRTLPLLPTNNRQFIVVSNTEEPSLNVHVVSPEHFKAFLSKTSRNLTIIGGSSLLTVDILSKMDKIIMTTVYGSFDADVYLPTEVVSYVTGKASNATLFNNSDAKMAVYYG"}}}}}}, "$insert": {"CARD_short_name": "dfrA3b"}}, "3402": {"$insert": {"CARD_short_name": "Tet(X4)"}}, "3343": {"$update": {"ARO_description": "dfrA6 is a dihydrofolate reductase that confers resistance to trimethoprim. Found in Proteus mirabilis."}, "$insert": {"CARD_short_name": "Pmir_dfrA6"}}, "3405": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-402"}}, "3340": {"$update": {"ARO_description": "aacA43 is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae."}, "$insert": {"CARD_short_name": "aacA43"}}, "2712": {"$update": {"ARO_description": "MexXY-OprA is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprA is the outer membrane channel. MexXY-OprA is associated with resistance to aminoglycosides.", "model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "MexXY-OprA"}}, "2713": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "MexXY-OprM"}}, "3341": {"$update": {"ARO_description": "A 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K) [Alkalihalobacillus halodurans].", "model_sequences": {"$update": {"sequence": {"$update": {"5470": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Alkalihalobacillus halodurans"}}}}}}}}}, "$insert": {"CARD_short_name": "Erm(K)"}}, "2716": {"$insert": {"CARD_short_name": "OpmB"}}, "2717": {"$insert": {"CARD_short_name": "MuxA"}}, "3346": {"$update": {"ARO_description": "AQU-2 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from Aeromonas."}, "$insert": {"CARD_short_name": "AQU-2"}}, "2718": {"$insert": {"CARD_short_name": "MuxB"}}, "3406": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-140"}}, "5329": {"$insert": {"CARD_short_name": "PDC-190"}}, "3347": {"$update": {"ARO_description": "AQU-3 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from."}, "$insert": {"CARD_short_name": "AQU-3"}}, "130": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1818": {"$update": {"dna_sequence": {"$update": {"accession": "JF274246.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-112"}}, "3409": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-123"}}, "5078": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-769"}}, "5079": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-770"}}, "3344": {"$insert": {"CARD_short_name": "dfrI"}}, "3408": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-122"}}, "5072": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-763"}}, "5073": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-764"}}, "5070": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-761"}}, "5071": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-762"}}, "5076": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-767"}}, "5077": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-768"}}, "5074": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-765"}}, "5075": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-766"}}, "1832": {"$update": {"ARO_description": "QnrS2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"145": {"$update": {"dna_sequence": {"$update": {"accession": "DQ485530.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS2"}}, "1833": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1379": {"$update": {"dna_sequence": {"$update": {"accession": "KF986255.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-374"}}, "1830": {"$update": {"model_sequences": {"$update": {"sequence": {"8275": {"dna_sequence": {"partial": "0", "sequence": "TTGAATCGAACTAATATTTTTTTTGGTGAATCGCATTCTGACTGGTTGCCTGTCAGAGGCGGAGAATCTGGTGATTTTGTTTTTCGACGTGGTGACGGGCATGCCTTCGCGAAAATCGCACCTGCTTCCCGCCGCGGTGAGCTCGCTGGAGAGCGTGACCGCCTCATTTGGCTCAAAGGTCGAGGTGTGGCTTGCCCCGAGGTGATCAACTGGCAGGAGGAACAGGAGGGTGCATGCTTGGTGATAACGGCAATTCCGGGAGTACCGGCGGCTGATCTGTCTGGAGCGGATTTGCTCAAAGCGTGGCCGTCAATGGGGCAGCAACTTGGCGCTGTTCACAGCCTATTGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGGACGCGCCGTTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCAGCTCGATCTTTTGGCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGATCCCTGCATGCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGCAGATCGCTATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCTTCGCTGTCCTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTGACTTGGGGTTGA", "fmax": "16397", "accession": "AF313472.2", "fmin": "15593", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "ABK33456.1", "sequence": "MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLLVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG"}}}}}, "ARO_category": {"$update": {"36266": {"$update": {"category_aro_description": "Phosphorylation of streptomycin on the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "APH(3'')-Ib"}}, "1831": {"$update": {"ARO_description": "AAC(6')-Iid is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus durans.", "model_sequences": {"$update": {"sequence": {"8166": {"dna_sequence": {"partial": "0", "sequence": "ATGATTATCAGTGAGTTTGATCGTGAGAATATTGTCTTGCGAGATCAGCTTGCAGATCTTTTAAGATTGACTTGGCCTGATGAGTATGGAACAGAGCCGATGAAAGAAGTCGAACAGTTGATGGCTCCAGAACGGATTGCTGTATCGGCGATTGAAGGGGAGGAATTGGTCGGTTTTGTTGGAGCGATCCCTCAATATGGCAAAACAGGGTGGGAGTTACATCCTTTGGTAGTAGCAAGCACACATCGCAAACAACAAATCGGGACACGATTGGTTTCCTACCTGGAAAAAGAAGTCGCTTCATATGGTGGCCTGGTCATCTATCTAGGGACAGATGATGTTGAAGGACAAACAAATTTAGTTGAAACGGATTTATTTGAAGATACCTTTGCAAAGTTACAAGAAATCAAAAATATCAATCATCATCCCTATACATTTTATGAGAAACTTGGCTATCAGATCATCGGTGTGATCCCAGATGCGAATGGGTGGAACCAGCCTGATATTTGGTTAGCAAAACGAGTGGCCAAACGAGAGCCAACGGAATAA", "fmax": "582", "accession": "AJ584700.2", "fmin": "33", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus hirae", "NCBI_taxonomy_id": "1354", "NCBI_taxonomy_cvterm_id": "39521"}, "protein_sequence": {"accession": "CAE50925.1", "sequence": "MIISEFDRENIVLRDQLADLLRLTWPDEYGTEPMKEVEQLMAPERIAVSAIEGEELVGFVGAIPQYGKTGWELHPLVVASTHRKQQIGTRLVSYLEKEVASYGGLVIYLGTDDVEGQTNLVETDLFEDTFAKLQEIKNINHHPYTFYEKLGYQIIGVIPDANGWNQPDIWLAKRVAKREPTE"}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iid"}}, "1836": {"$update": {"ARO_description": "OXA-201 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1372": {"$update": {"dna_sequence": {"$update": {"accession": "HQ734812.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-201"}}, "3798": {"$insert": {"CARD_short_name": "Tet(X5)"}}, "1834": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"852": {"$update": {"dna_sequence": {"$update": {"accession": "AJ318094.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-94"}}, "1835": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"537": {"$update": {"dna_sequence": {"$update": {"accession": "AY825285.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(38)"}}, "3795": {"$insert": {"CARD_short_name": "ArnT"}}, "3794": {"$update": {"ARO_category": {"$update": {"43251": {"$update": {"category_aro_description": "LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins."}}}}}, "$insert": {"CARD_short_name": "LpsA"}}, "1838": {"$update": {"ARO_description": "ACT-5 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1893": {"$update": {"dna_sequence": {"$update": {"accession": "FJ237369.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-5"}}, "1839": {"$update": {"ARO_description": "aadA14 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in Pasteurella multocida.", "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA14"}}, "3791": {"$insert": {"CARD_short_name": "eptB"}}, "3790": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MecI_rep"}}, "3793": {"$update": {"ARO_category": {"$update": {"43251": {"$update": {"category_aro_description": "LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins."}}}}}, "$insert": {"CARD_short_name": "LpsB"}}, "3792": {"$insert": {"CARD_short_name": "CrcB"}}, "4981": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-661"}}, "4980": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-660"}}, "2156": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-14"}}, "2157": {"$update": {"ARO_description": "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to gentamicin C.", "model_sequences": {"$update": {"sequence": {"$update": {"3233": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C"}, "$insert": {"CARD_short_name": "Ecol_16S_GENC"}}, "4985": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7360": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-669"}}, "2403": {"$insert": {"CARD_short_name": "Sent_gyrA_FLO"}}, "2400": {"$update": {"ARO_description": "RND efflux pump conferring resistance to fluoroquinolone."}, "$insert": {"CARD_short_name": "oqxB"}}, "4986": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-670"}}, "4989": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-676"}}, "4988": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-675"}}, "931": {"$update": {"ARO_description": "OXA-316 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1609": {"$update": {"dna_sequence": {"$update": {"accession": "KF057033.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-316"}}, "2158": {"$update": {"ARO_description": "Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin."}, "$insert": {"CARD_short_name": "Ecol_EFTu_PLV"}}, "936": {"$update": {"ARO_description": "OKP-A-13 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1040": {"$update": {"dna_sequence": {"$update": {"accession": "FJ534513.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-13"}}, "935": {"$update": {"ARO_description": "OXA-314 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1458": {"$update": {"dna_sequence": {"$update": {"accession": "KF057031.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-314"}}, "934": {"$update": {"ARO_description": "IMP-8 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8171": {"dna_sequence": {"partial": "0", "sequence": "ATGAAGAAATTATTTGTTTTATGTGTATGCTTCCTTTGTAGCATTACTGCCGCAGGAGCGGCTTTGCCTGATTTAAAAATCGAGAAGCTTGAAGAAGGTGTTTATGTTCATACATCGTTCGAAGAAGTTAACGGTTGGGGTGTTGTTTCTAAACACGGTTTGGTGGTTCTTGTAAACACTGACGCCTATCTGATTGACACTCCATTTACTGCTACAGATACTGAAAAGTTAGTCAATTGGTTTGTGGAGCGCGGCTATAAAATCAAAGGCACTATTTCCTCACATTTCCATAGCGACAGCACAGGGGGAATAGAGTGGCTTAATTCTCAATCTATTCCCACGTATGCATCTGAATTAACAAATGAACTTCTTAAAAAAGACGGTAAGGTGCAAGCTAAAAACTCATTTAGCGGAGTTAGTTATTGGCTAGTTAAAAATAAAATTGAAGTTTTTTATCCCGGCCCGGGGCACACTCAAGATAACGTAGTGGTTTGGTTACCTGAAAAGAAAATTTTATTCGGTGGTTGTTTTGTTAAACCGGACGGTCTTGGTAATTTGGGTGACGCAAATTTAGAAGCTTGGCCAAAGTCCGCCAAAATATTAATGTCTAAATATGGTAAAGCAAAACTGGTTGTTTCAAGTCATAGTGAAATTGGGGACGCATCACTCTTGAAACGTACATGGGAACAGGCTGTTAAAGGGCTAAATGAAAGTAAAAAACCATCACAGCCAAGTAACTAA", "fmax": "2822", "accession": "AF322577.2", "fmin": "2081", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAK13430.1", "sequence": "MKKLFVLCVCFLCSITAAGAALPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEIGDASLLKRTWEQAVKGLNESKKPSQPSN"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-8"}}, "5380": {"$insert": {"CARD_short_name": "PDC-242"}}, "5381": {"$insert": {"CARD_short_name": "PDC-243"}}, "5382": {"$insert": {"CARD_short_name": "PDC-244"}}, "5383": {"$insert": {"CARD_short_name": "PDC-245"}}, "5384": {"$insert": {"CARD_short_name": "PDC-246"}}, "5385": {"$insert": {"CARD_short_name": "PDC-247"}}, "5386": {"$insert": {"CARD_short_name": "PDC-248"}}, "5387": {"$insert": {"CARD_short_name": "PDC-249"}}, "5388": {"$insert": {"CARD_short_name": "PDC-25"}}, "5389": {"$insert": {"CARD_short_name": "PDC-250"}}, "2015": {"$update": {"ARO_description": "DHA-3 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1631": {"$update": {"dna_sequence": {"$update": {"accession": "AY494945.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-3"}}, "136": {"$update": {"ARO_description": "CMY-9 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1363": {"$update": {"dna_sequence": {"$update": {"accession": "AB061794.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-9"}}, "1955": {"$update": {"ARO_description": "OXA-29 is a beta-lactamase found in Legionella gormanii.", "model_sequences": {"$update": {"sequence": {"$update": {"973": {"$update": {"dna_sequence": {"$update": {"accession": "AJ400619.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-29"}}, "1954": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1243": {"$update": {"dna_sequence": {"$update": {"accession": "FJ807656.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-154"}}, "1957": {"$update": {"ARO_description": "VIM-18 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1407": {"$update": {"dna_sequence": {"$update": {"accession": "AM778091.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-18"}}, "1956": {"$update": {"ARO_description": "IMI-1 is a beta-lactamase found in Enterobacter cloacae.", "model_sequences": {"$update": {"sequence": {"$update": {"1190": {"$update": {"dna_sequence": {"$update": {"accession": "U50278.1"}}}}}}}}}, "$insert": {"CARD_short_name": "IMI-1"}}, "1951": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1887": {"$update": {"dna_sequence": {"$update": {"accession": "AF190694.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-76"}}, "1950": {"$update": {"ARO_description": "arr-1 is a chromosome-encoded ribosyltransferase found in Mycolicibacterium smegmatis.", "model_sequences": {"$update": {"sequence": {"$update": {"393": {"$update": {"dna_sequence": {"$update": {"accession": "AF001493.1"}}}}}}}}}, "$insert": {"CARD_short_name": "arr-1"}}, "1953": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1472": {"$update": {"dna_sequence": {"$update": {"accession": "JX121122.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-155"}}, "1952": {"$update": {"ARO_description": "OXA-1 is a beta-lactamase found in E. coli.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-1"}}, "4408": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6783": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "CAR-1"}}, "1959": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"759": {"$update": {"dna_sequence": {"$update": {"accession": "FJ237368.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-7"}}, "1958": {"$update": {"ARO_description": "VIM-33 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1331": {"$update": {"dna_sequence": {"$update": {"accession": "JX258134.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-33"}}, "4409": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-11"}}, "5545": {"$insert": {"CARD_short_name": "PDC-416"}}, "4872": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-538"}}, "4404": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-8"}}, "829": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1089": {"$update": {"dna_sequence": {"$update": {"accession": "KM087850.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-17"}}, "828": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1249": {"$update": {"dna_sequence": {"$update": {"accession": "AF427129.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-83"}}, "4405": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-9"}}, "825": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1314": {"$update": {"dna_sequence": {"$update": {"accession": "AF117744.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-20"}}, "824": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"179": {"$update": {"dna_sequence": {"$update": {"accession": "AY082011.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanD"}}, "827": {"$update": {"ARO_description": "QnrB55 is a plasmid-mediated quinolone resistance protein found in Raoultella terrigena.", "model_sequences": {"$update": {"sequence": {"$update": {"389": {"$update": {"dna_sequence": {"$update": {"accession": "KF730650.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB55"}}, "826": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"563": {"$update": {"dna_sequence": {"$update": {"accession": "FJ768952.1"}}}}}}}}, "model_name": "TolC", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "TolC"}}, "821": {"$update": {"ARO_description": "Specific mutations that occurs on Mycobacterium tuberculosis embB causing it to be rifampicin resistant.", "model_sequences": {"$update": {"sequence": {"$update": {"3327": {"$update": {"dna_sequence": {"$update": {"accession": "AE000516.1"}}}}}}}}, "model_name": "Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin"}, "$insert": {"CARD_short_name": "Mtub_embB_RIF"}}, "820": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"215": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}}, "$insert": {"CARD_short_name": "mdtB"}}, "822": {"$update": {"ARO_description": "QnrD1 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"746": {"$update": {"dna_sequence": {"$update": {"accession": "FJ228229.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrD1"}}, "4259": {"$insert": {"CARD_short_name": "ADC-194"}}, "4407": {"$insert": {"CARD_short_name": "BUT-2"}}, "4258": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6633": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ADC-193"}}, "2409": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40661": {"$update": {"category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}}}}}, "$insert": {"CARD_short_name": "Nmen_PBP2_BLA"}}, "4400": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6775": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-39"}}, "4312": {"$insert": {"CARD_short_name": "ADC-246"}}, "4401": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-5"}}, "1483": {"$update": {"ARO_description": "AAC(3)-Xa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces griseus."}, "$insert": {"CARD_short_name": "AAC(3)-Xa"}}, "1482": {"$update": {"ARO_description": "SME-1 is a beta-lactamase found in Serratia marcescens.", "model_sequences": {"$update": {"sequence": {"$update": {"1319": {"$update": {"dna_sequence": {"$update": {"accession": "Z28968.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SME-1"}}, "1481": {"$update": {"ARO_description": "OXY-1-4 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"896": {"$update": {"dna_sequence": {"$update": {"accession": "AY077483.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-1-4"}}, "1480": {"$update": {"ARO_description": "Class A beta-lactamase found in Streptomyces albus G.", "model_sequences": {"$update": {"sequence": {"$update": {"3292": {"$update": {"dna_sequence": {"$update": {"accession": "M28303.1"}}}}}}}}, "model_name": "EXO-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "EXO-1"}}, "5498": {"$insert": {"CARD_short_name": "PDC-368"}}, "5499": {"$insert": {"CARD_short_name": "PDC-369"}}, "1485": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1519": {"$update": {"dna_sequence": {"$update": {"accession": "JX173956.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-8"}}, "1484": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"941": {"$update": {"dna_sequence": {"$update": {"accession": "KJ207209.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-27"}}, "5494": {"$insert": {"CARD_short_name": "PDC-364"}}, "5495": {"$insert": {"CARD_short_name": "PDC-365"}}, "5496": {"$insert": {"CARD_short_name": "PDC-366"}}, "5497": {"$insert": {"CARD_short_name": "PDC-367"}}, "5490": {"$insert": {"CARD_short_name": "PDC-360"}}, "3303": {"$insert": {"CARD_short_name": "ermZ"}}, "3300": {"$insert": {"CARD_short_name": "clcD"}}, "3301": {"$update": {"ARO_description": "LnuP is a lincosamide nucleotidyltransferase major efflux facilitator."}, "$insert": {"CARD_short_name": "LnuP"}}, "1713": {"$update": {"ARO_description": "Also known as vanYM, is a vanY variant found in the vanM gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"479": {"$update": {"dna_sequence": {"$update": {"accession": "FJ349556.1"}}}}}}}}, "model_name": "vanY gene in vanM cluster", "ARO_name": "vanY gene in vanM cluster"}, "$insert": {"CARD_short_name": "vanY_in_vanM_cl"}}, "1712": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1970": {"$update": {"dna_sequence": {"$update": {"accession": "AB753458.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-41"}}, "5250": {"$insert": {"CARD_short_name": "PDC-112"}}, "794": {"$update": {"ARO_description": "Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin."}, "$insert": {"CARD_short_name": "Saur_rpoC_DAP"}}, "793": {"$update": {"model_sequences": {"$update": {"sequence": {"8228": {"dna_sequence": {"partial": "0", "sequence": "ATGAGCAAGTTATCTGTATTCTTTATATTTTTGTTTTGCAGCATTGCTACCGCAGCAGAGTCTTTGCCAGATTTAAAAATTGAAAAGCTTGATGAAGGCGTTTATGTTCATACTTCGTTTGAAGAAGTTAACGGGTGGGGCGTTGTTCCTAAACATGGTTTGGTGGTTCTTGTAAATGCTGAGGCTTATTTAATTGACACTCCATTTACGGCTAAAGATACTGAAAAGTTAGTCACTTGGTTTGTGGAGCGTGGCTATAAAATAAAAGGCAGTATTTCCTCTCATTTTCATAGCGACAGCACGGGCGGAATAGGGTGGCTTAATTCTCGATCTATCCCCACGTATGCATCTGAATTAACAAATGAACTGCTTAAAAAAGACGGTAAGGTTCAAGCCACAAATTCATTTAGCGGAGTTAACTATTGGCTAGTTAAAAATAAAATTGAAGTTTTTTATCCAGGCCCGGGACACACTCCAGATAACGTAGTGGTTTGGCTGCCTGAAAGGAAAATATTATTCGGTGGTTGTTTTATTAAACCGTACGGTTTAGGCAATTTGGGTGACGCAAATATAGAAGCTTGGCCAAAGTCCGCCAAATTATTAAAGTCCAAATATGGTAAGGCAAAACTGGTTGTTCCAAGTCACAGTGAAGTTGGAGACGCATCACTCTTGAAACTTACATTAGAGCAGGCGGTTAAAGGATTAAACGAAAGTAAAAAACCATCAAAACCAAGCAACTAA", "fmax": "27966", "accession": "AB715422.2", "fmin": "27225", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella oxytoca", "NCBI_taxonomy_id": "571", "NCBI_taxonomy_cvterm_id": "36788"}, "protein_sequence": {"accession": "BAP75826.1", "sequence": "MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIGWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-34"}}, "792": {"$update": {"ARO_description": "OXY-1-1 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1938": {"$update": {"dna_sequence": {"$update": {"accession": "Z30177.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-1-1"}}, "791": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1471": {"$update": {"dna_sequence": {"$update": {"accession": "AF226622.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-14"}}, "790": {"$update": {"ARO_description": "CMY-32 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1858": {"$update": {"dna_sequence": {"$update": {"accession": "EU496815.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-32"}}, "1719": {"$update": {"ARO_description": "ceoA is a periplasmic linker subunit of the CeoAB-OpcM efflux pump.", "model_sequences": {"$update": {"sequence": {"$update": {"302": {"$update": {"dna_sequence": {"$update": {"accession": "U97042.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ceoA"}}, "1718": {"$update": {"ARO_description": "Dutch imipenemase or DIM-1 is an integron-encoded metallo-beta-lactamase from Pseudomonas stutzeri.", "model_sequences": {"$update": {"sequence": {"8218": {"dna_sequence": {"partial": "0", "sequence": "ATGAGAACACATTTTACAGCGTTATTACTTCTATTCAGCTTGTCTTCGCTTGCTAACGACGAGGTACCTGAGCTAAGAATCGAGAAAGTAAAAGAGAACATCTTTTTGCACACATCATACAGTCGTGTGAATGGGTTTGGTTTGGTCAGTTCAAACGGCCTTGTTGTCATAGATAAGGGTAATGCTTTCATTGTTGATACACCTTGGTCAGACCGAGATACAGAAACGCTCGTACATTGGATTCGTAAAAATGGTTATGAGCTACTGGGGAGTGTTTCTACTCATTGGCATGAGGATAGAACCGCAGGAATTAAATGGCTTAATGACCAATCAATTTCTACGTATGCCACGACTTCAACCAACCATCTCTTGAAAGAAAATAAAAAAGAGCCAGCGAAATACACCTTGAAAGGAAATGAGTCCACATTGGTTGACGGCCTTATCGAAGTATTTTATCCAGGAGGTGGTCATACAATAGACAACGTAGTGGTGTGGTTGCCAAAGTCGAAAATCTTATTTGGCGGCTGTTTTGTGCGTAGCCTTGATTCCGAGGGGTTAGGCTACACTGGTGAAGCCCATATTGATCAATGGTCCCGATCAGCTCAGAATGCTCTGTCTAGGTACTCAGAAGCCCAGATAGTAATTCCTGGCCATGGGAAAATCGGGGATATAGCGCTGTTAAAACACACCAAAAGTCTGGCTGAGACAGCCTCTAACAAATCAATCCAGCCGAACGCTAACGCGTCGGCTGATTGA", "fmax": "796", "accession": "KC004136.2", "fmin": "40", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter sp. SL1", "NCBI_taxonomy_id": "1284354", "NCBI_taxonomy_cvterm_id": "39662"}, "protein_sequence": {"accession": "AGC92784.1", "sequence": "MRTHFTALLLLFSLSSLANDEVPELRIEKVKENIFLHTSYSRVNGFGLVSSNGLVVIDKGNAFIVDTPWSDRDTETLVHWIRKNGYELLGSVSTHWHEDRTAGIKWLNDQSISTYATTSTNHLLKENKKEPAKYTLKGNESTLVDGLIEVFYPGGGHTIDNVVVWLPKSKILFGGCFVRSLDSEGLGYTGEAHIDQWSRSAQNALSRYSEAQIVIPGHGKIGDIALLKHTKSLAETASNKSIQPNANASAD"}}}}}, "model_name": "DIM-1"}, "$insert": {"CARD_short_name": "DIM-1"}}, "799": {"$update": {"ARO_description": "CTX-M-31 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"786": {"$update": {"dna_sequence": {"$update": {"accession": "AJ567481.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-31"}}, "798": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"492": {"$update": {"dna_sequence": {"$update": {"accession": "AB894099.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cmeC"}}, "612": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1849": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666070.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PDC-7"}}, "2144": {"$update": {"ARO_description": "Point mutations that occur within Mycobacterium tuberculosis variant bovis embB gene resulting in resistance to ethambutol.", "model_sequences": {"$update": {"sequence": {"$update": {"3355": {"$update": {"dna_sequence": {"$update": {"accession": "BX248333.1"}}}}}}}}, "model_name": "Mycobacterium tuberculosis variant bovis embB with mutation conferring resistance to ethambutol"}, "$insert": {"CARD_short_name": "Mbov_embB_EMB"}}, "4319": {"$insert": {"CARD_short_name": "ADC-253"}}, "4978": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-658"}}, "1272": {"$update": {"ARO_description": "CTX-M-67 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1187": {"$update": {"dna_sequence": {"$update": {"accession": "EF581888.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-67"}}, "4979": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-659"}}, "1139": {"$update": {"ARO_description": "dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae."}, "$insert": {"CARD_short_name": "dfrA12"}}, "1138": {"$insert": {"CARD_short_name": "tet(D)"}}, "4386": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6761": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-25"}}, "1133": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"985": {"$update": {"dna_sequence": {"$update": {"accession": "EU418913.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-109"}}, "1132": {"$update": {"ARO_description": "OXA-88 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1058": {"$update": {"dna_sequence": {"$update": {"accession": "DQ392963.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-88"}}, "1131": {"$update": {"ARO_description": "AAC(3)-Ic is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"47": {"$update": {"dna_sequence": {"$update": {"accession": "AJ511268.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-Ic"}}, "1130": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2018": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666072.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PDC-9"}}, "1137": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1804": {"$update": {"dna_sequence": {"$update": {"accession": "AF351241.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-90"}}, "1136": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"764": {"$update": {"dna_sequence": {"$update": {"accession": "JQ664733.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-6"}}, "1135": {"$update": {"ARO_description": "Point mutation in Staphylococcus aureus parE resulting in aminocoumarin resistance."}, "$insert": {"CARD_short_name": "Saur_parE_AMU"}}, "1275": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"367": {"$update": {"dna_sequence": {"$update": {"accession": "M64090.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmT"}}, "4974": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-654"}}, "4257": {"$insert": {"CARD_short_name": "ADC-192"}}, "2793": {"$update": {"model_name": "Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin"}, "$insert": {"CARD_short_name": "Crei_23S_ERY"}}, "3378": {"$update": {"ARO_description": "A 16S rRNA mathyltransferase gene with a single nucleotide mutation compared to rmtE.", "model_sequences": {"$update": {"sequence": {"8350": {"dna_sequence": {"partial": "0", "sequence": "ATGAATATTGATGAAATGGCTGCAGAGGTTCTGTCGAGCAAAAAATATACAAGCGTTGACCCTGCTGTTGTTAGGCGTGTTTGTATGGAAACAGCACCTAAATATCCGAAGAAAAAAGAAGCAATAAAAGCGGTAAAAAATGAACTGCATATCATCCATGAGGTTTTTTTGCAAAACGAATGTTACAAAAATGCGCTTTCATTTTTATCACAGCTATCCTTAGATTTTAATAATGCGCAATTGATCGATATTACTATGCAAATCATGCAATCACATACATCAACCAAAGAGAGATTAGGCGACATTGAAGCGGTTTGTTCATTCTTAAGCACCCATATATCCAAAGAGGGTTCCGTGATGGACATCGGTTGTGGCTTCAATCCATTTGCGTTGCCATTACTGCACGAGTTCCCGGCAACGTATTATGCTTATGATATATGTTCAGAAGGAATTAACATCCTAAACAAATATTTCTCCATCCTAAAAAAAGGAGAATATAGAGCGGAGCTACTTGATGCCGTGTCTGTTACGCCGAAAGAAAAGGTGGATGTTGCCCTCCTATTCAAGCTATTACCTTTGTTGCAGCAACAGAAAAAAGGTCGAGGTTTCAGCATTTTAGAAGAACTGGACTTTGACAAAGCAATTGTATCTTTTCCAATAAAAAGCTTGGGAGGAAAGCAAAAAGGAATGGAAACCTTTTATTCGAATTTGTTTGAAGAAAACCTGCCTTCCTCATTGGAAATCATTGAGAAGCAGACTTTTTCAAATGAGATGTTCTATGTGATACAAAACAAAACCAAAAACGGAGGAAATCAATCATGA", "fmax": "2668", "accession": "KT428293.1", "fmin": "1846", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ALD03565.1", "sequence": "MNIDEMAAEVLSSKKYTSVDPAVVRRVCMETAPKYPKKKEAIKAVKNELHIIHEVFLQNECYKNALSFLSQLSLDFNNAQLIDITMQIMQSHTSTKERLGDIEAVCSFLSTHISKEGSVMDIGCGFNPFALPLLHEFPATYYAYDICSEGINILNKYFSILKKGEYRAELLDAVSVTPKEKVDVALLFKLLPLLQQQKKGRGFSILEELDFDKAIVSFPIKSLGGKQKGMETFYSNLFEENLPSSLEIIEKQTFSNEMFYVIQNKTKNGGNQS"}}}}}}, "$insert": {"CARD_short_name": "rmtE2"}}, "4256": {"$insert": {"CARD_short_name": "ADC-191"}}, "4976": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-656"}}, "4977": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-657"}}, "3013": {"$update": {"ARO_description": "A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii."}, "$insert": {"CARD_short_name": "ADC-68"}}, "3014": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-55"}}, "3015": {"$update": {"ARO_description": "An IMP class B metallo-beta-lactamase enzyme identified from carbapenem-resistant Pseudomonas aeruginosa.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-56"}}, "519": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1963": {"$update": {"dna_sequence": {"$update": {"accession": "FR748153.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-26"}}, "518": {"$update": {"ARO_description": "Also known as vanXYN, is a vanXY variant found in the vanN gene cluster.", "model_sequences": {"$update": {"sequence": {"8149": {"dna_sequence": {"partial": "0", "sequence": "ATGCATAATTTTTATTTACAGCTTGTAAACCAACAACACCCTTGGAAATCATTTAATCATTCGCCACAGCTTGTTCAAGCGACCTATGCGGAAGAAAAGATTTTAATAGATTCCAAGGTTAACCATCAATTCAATCAGTTACTTGAAACACTACAATTAACTGATCGCATCATGATCGTTGATGGTCATCGAACGGTTGCTGAGCAAAAACATTTGTGGAACTATTCTTTAAACGCACATGGGGTGAATTATACAAAAAGTTATGTAGCATCTCCTGGCTGTAGTGAACATCATACGGGACTAGCAATTGATCTCGGTCTACGAAAGACAGAACATGATCTCATTGCGCCACGCTTCGAGGGACCAGAAGCCGAACTGTTTTTACAACATATGAAAGATTATGGATTTATTTTACGCTATCCTAAAAATAAGCAAAAAATTACAGGAATTGCTTATGAGCCTTGGCATTTTCGCTATGTAGGTACCCCTCATAGTCAAATCATCATGGACCACGGATGGACCTTAGAAGAGTATATTGAATTTTTAAAACATCAAATTGAGGCGGTCTCATGA", "fmax": "2165", "accession": "JF802084.2", "fmin": "1592", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"accession": "AEP40501.1", "sequence": "MHNFYLQLVNQQHPWKSFNHSPQLVQATYAEEKILIDSKVNHQFNQLLETLQLTDRIMIVDGHRTVAEQKHLWNYSLNAHGVNYTKSYVASPGCSEHHTGLAIDLGLRKTEHDLIAPRFEGPEAELFLQHMKDYGFILRYPKNKQKITGIAYEPWHFRYVGTPHSQIIMDHGWTLEEYIEFLKHQIEAVS"}}}}}, "model_name": "vanXY gene in vanN cluster", "ARO_name": "vanXY gene in vanN cluster"}, "$insert": {"CARD_short_name": "vanXY_in_vanN"}}, "4972": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-651"}}, "1009": {"$update": {"ARO_description": "IND-1 is a beta-lactamase found in Chryseobacterium indologenes.", "model_sequences": {"$update": {"sequence": {"$update": {"1595": {"$update": {"dna_sequence": {"$update": {"accession": "AF099139.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-1"}}, "1008": {"$update": {"ARO_description": "BEL-1 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1193": {"$update": {"dna_sequence": {"$update": {"accession": "DQ089809.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BEL-1"}}, "1007": {"$update": {"ARO_description": "OKP-A-8 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1830": {"$update": {"dna_sequence": {"$update": {"accession": "AM051147.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-8"}}, "510": {"$update": {"ARO_description": "CTX-M-9 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1706": {"$update": {"dna_sequence": {"$update": {"accession": "AF174129.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-9"}}, "513": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1019": {"$update": {"dna_sequence": {"$update": {"accession": "KJ934267.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-19"}}, "1004": {"$update": {"ARO_description": "Also known as vanRD, is a mutated vanR variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis.", "model_sequences": {"$update": {"sequence": {"$update": {"122": {"$update": {"dna_sequence": {"$update": {"accession": "AY082011.1"}}}}}}}}, "model_name": "vanR gene in vanD cluster", "ARO_name": "vanR gene in vanD cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanD_cl"}}, "1003": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1206": {"$update": {"dna_sequence": {"$update": {"accession": "U85514.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-18"}}, "1002": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"401": {"$update": {"dna_sequence": {"$update": {"accession": "AF445082.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ib4"}}, "1001": {"$update": {"ARO_description": "Point mutations that occur within Staphylococcus aureus mprF gene resulting in resistance to daptomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"3542": {"$update": {"dna_sequence": {"$update": {"accession": "HM140977.1"}}, "protein_sequence": {"$update": {"accession": "ADJ67256.1"}}}}}}}}, "model_name": "Staphylococcus aureus mprF with mutation conferring resistance to daptomycin"}, "$insert": {"CARD_short_name": "Saur_mprF_DAP"}}, "1000": {"$update": {"ARO_description": "AAC(6')-Ib-Hangzhou is an aminoglycoside acetyltransferase in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"29": {"$update": {"dna_sequence": {"$update": {"accession": "FJ503047.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC6_IB_HZ"}}, "1227": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3404": {"$update": {"dna_sequence": {"$update": {"accession": "AF156486.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA2"}}, "4188": {"$insert": {"CARD_short_name": "ADC-114"}}, "1225": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1492": {"$update": {"dna_sequence": {"$update": {"accession": "X97254.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-178"}}, "620": {"$update": {"ARO_description": "OXA-320 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1840": {"$update": {"dna_sequence": {"$update": {"accession": "KF151169.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-320"}}, "1223": {"$update": {"ARO_description": "vph is a phosphotransferase that confers resistance to viomycin in Streptomyces vinaceus.", "model_sequences": {"$update": {"sequence": {"$update": {"62": {"$update": {"dna_sequence": {"$update": {"accession": "X02393.1"}}}}}}}}, "model_name": "vph"}, "$insert": {"CARD_short_name": "vph"}}, "626": {"$update": {"ARO_description": "Also known as vanHB, is a vanH variant in the vanB gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3452": {"$update": {"dna_sequence": {"$update": {"accession": "U35369.1"}}}}}}}}, "model_name": "vanH gene in vanB cluster", "ARO_name": "vanH gene in vanB cluster"}, "$insert": {"CARD_short_name": "vanH_in_vanB_cl"}}, "625": {"$update": {"ARO_description": "QnrB46 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8169": {"dna_sequence": {"partial": "0", "sequence": "ATGACGCCATTACTGTATAAGAAAACAGGAACAAATATGGCTCTAGCGCTCGTGGGCGAAAAAATTGACAGAAACCGTTTCACCGGTGAAAAAATTGAAAATAGTACATTTTTTAACTGTGATTTTTCAGGAGCGGACCTGAGCGGCACTGAGTTTATCGGCTGCCAATTTTATGATCGTGAAAGCCAGAAAGGCTGTAATTTTAGCCGTGCGATGTTAAAGGATGCTATTTTTAAAAGCTGCGATTTATCCATGGCCGATTTTCGCAATGCAAGCGCCCTGGGTATTGAGATTCGTCATTGTAGGGCTCAGGGTGCAGATTTTCGCGGCGCAAGCTTTATGAACATGATTACCACGCGAACTTGGTTCTGCAGCGCGTATATCACGAATACGAATCTGTCTTATGCCAATTTTTCGAAAGCAGTGTTGGAGAAGTGTGAATTATGGGAAAACCGTTGGATGGGTGCCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCAACTTTCGACTGGCGAGCAGCAAACTTTACACATTGCGATCTCACAAATTCGGAGTTGGGTGACTTAGATATTCGTCGGGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCTTCGTTGCTCATGGAGCGACTTGGCATCGCGATAATTGGATGA", "fmax": "681", "accession": "HQ704413.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "ADW54092.1", "sequence": "MTPLLYKKTGTNMALALVGEKIDRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKAVLEKCELWENRWMGAQVLGATFSGSDLSGGEFSTFDWRAANFTHCDLTNSELGDLDIRRVDLQGVKLDNYQASLLMERLGIAIIG"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB46"}}, "1220": {"$update": {"ARO_description": "OCH-5 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi.", "model_sequences": {"$update": {"sequence": {"$update": {"1734": {"$update": {"dna_sequence": {"$update": {"accession": "AJ295343.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Brucella anthropi"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36233": {"$update": {"category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi."}}}}}, "$insert": {"CARD_short_name": "OCH-5"}}, "4181": {"$insert": {"CARD_short_name": "ADC-105"}}, "4180": {"$insert": {"CARD_short_name": "ADC-104"}}, "629": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"854": {"$update": {"dna_sequence": {"$update": {"accession": "JF900599.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-28"}}, "628": {"$update": {"ARO_description": "catB10 is an integron-encoded variant of the cat gene found in P. aeruginosa.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catB10"}}, "4185": {"$insert": {"CARD_short_name": "ADC-110"}}, "4184": {"$insert": {"CARD_short_name": "ADC-109"}}, "1229": {"$update": {"ARO_description": "CTX-M-6 is a beta-lactamase found in Salmonella typhimurium.", "model_sequences": {"$update": {"sequence": {"$update": {"1863": {"$update": {"dna_sequence": {"$update": {"accession": "AJ005044.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-6"}}, "1228": {"$update": {"model_sequences": {"$update": {"sequence": {"8164": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGGTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA", "fmax": "1143", "accession": "EF685372.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ABS12249.1", "sequence": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHGSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ"}}}}}}, "$insert": {"CARD_short_name": "CMY-30"}}, "5663": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8038": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SPU-1"}}, "5662": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8037": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SPS-1"}}, "5661": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8036": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SPR-1"}}, "5660": {"$insert": {"CARD_short_name": "SPN79-1"}}, "5666": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8041": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "STA-1"}}, "4349": {"$insert": {"CARD_short_name": "ADC-93"}}, "4348": {"$insert": {"CARD_short_name": "ADC-92"}}, "4347": {"$insert": {"CARD_short_name": "ADC-91"}}, "4346": {"$insert": {"CARD_short_name": "ADC-90"}}, "4345": {"$insert": {"CARD_short_name": "ADC-89"}}, "4344": {"$insert": {"CARD_short_name": "ADC-88"}}, "4343": {"$insert": {"CARD_short_name": "ADC-87"}}, "4342": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6717": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ADC-86"}}, "4341": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6716": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ADC-85"}}, "4340": {"$insert": {"CARD_short_name": "ADC-84"}}, "2882": {"$insert": {"CARD_short_name": "tet(W/N/W)"}}, "2880": {"$insert": {"CARD_short_name": "QepA4"}}, "2881": {"$insert": {"CARD_short_name": "tet(59)"}}, "2886": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40661": {"$update": {"category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}}}}}, "$insert": {"CARD_short_name": "Hinf_PBP3_BLA"}}, "2884": {"$update": {"ARO_category": {"$update": {"41636": {"$update": {"category_aro_description": "A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity."}}}}}, "$insert": {"CARD_short_name": "RSA-1"}}, "2885": {"$update": {"ARO_category": {"$update": {"41636": {"$update": {"category_aro_description": "A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity."}}}}}, "$insert": {"CARD_short_name": "RSA-2"}}, "2888": {"$update": {"ARO_description": "A class A beta-lactamase with penicillinase activity described in Atlantibacter (Escherichia) hermannii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "HERA-1"}}, "2889": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "41644": {"$update": {"category_aro_description": "A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi)."}}}}}, "$insert": {"CARD_short_name": "TRU-1"}}, "2": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1188": {"$update": {"dna_sequence": {"$update": {"accession": "GQ343019.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CblA-1"}}, "1081": {"$update": {"ARO_description": "IMP-30 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1174": {"$update": {"dna_sequence": {"$update": {"accession": "DQ522237.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-30"}}, "4392": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-30"}}, "3878": {"$insert": {"CARD_short_name": "PDC-69"}}, "3879": {"$update": {"ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-XV"}}, "1561": {"$update": {"ARO_description": "Also known as vanTG, is a vanT variant found in the vanG gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"217": {"$update": {"dna_sequence": {"$update": {"accession": "DQ212986.1"}}}}}}}}, "model_name": "vanT gene in vanG cluster", "ARO_name": "vanT gene in vanG cluster"}, "$insert": {"CARD_short_name": "vanT_in_vanG_cl"}}, "3870": {"$insert": {"CARD_short_name": "PDC-61"}}, "3871": {"$insert": {"CARD_short_name": "PDC-45"}}, "3872": {"$insert": {"CARD_short_name": "PDC-49"}}, "3873": {"$insert": {"CARD_short_name": "PDC-50"}}, "3874": {"$insert": {"CARD_short_name": "PDC-48"}}, "3875": {"$insert": {"CARD_short_name": "PAC-1"}}, "3876": {"$insert": {"CARD_short_name": "PDC-53"}}, "3877": {"$insert": {"CARD_short_name": "PDC-72"}}, "1286": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1235": {"$update": {"dna_sequence": {"$update": {"accession": "AY036620.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-34"}}, "5434": {"$insert": {"CARD_short_name": "PDC-303"}}, "11": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"162": {"$update": {"dna_sequence": {"$update": {"accession": "AY234334.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Alkalihalobacillus clausii"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Erm(34)"}}, "10": {"$update": {"ARO_description": "CARB-5 is a beta-lactamase found in Acinetobacter calcoaceticus.", "model_sequences": {"$update": {"sequence": {"$update": {"1661": {"$update": {"dna_sequence": {"$update": {"accession": "AF135373.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-5"}}, "13": {"$update": {"ARO_description": "LRA-12 is a beta-lactamase isolated from soil samples in Alaska.", "model_sequences": {"$update": {"sequence": {"$update": {"1445": {"$update": {"dna_sequence": {"$update": {"accession": "EU408351.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-12"}}, "12": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1567": {"$update": {"dna_sequence": {"$update": {"accession": "AY628199.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-126"}}, "15": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"931": {"$update": {"dna_sequence": {"$update": {"accession": "AF062386.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-59"}}, "14": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1651": {"$update": {"dna_sequence": {"$update": {"accession": "AF157553.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-72"}}, "17": {"$update": {"ARO_description": "Tet45 is a tetracycline efflux pump found in Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil."}, "$insert": {"CARD_short_name": "tet(45)"}}, "5718": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-69"}}, "5717": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-68"}}, "5716": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-67"}}, "5715": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-66"}}, "5714": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-65"}}, "5713": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-64"}}, "5712": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-63"}}, "5711": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-62"}}, "5710": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-61"}}, "3272": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-343"}}, "1572": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1682": {"$update": {"dna_sequence": {"$update": {"accession": "JF800667.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-205"}}, "4320": {"$insert": {"CARD_short_name": "ADC-254"}}, "3470": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5664": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Acinetobacter gerneri DSM 14967 = CIP 107464 = MTCC 9824"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-308"}}, "948": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mecI"}}, "1571": {"$update": {"ARO_description": "Also known as vanSE, is a vanS variant found in the vanE gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"649": {"$update": {"dna_sequence": {"$update": {"accession": "FJ872411.1"}}}}}}}}, "model_name": "vanS gene in vanE cluster", "ARO_name": "vanS gene in vanE cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanE_cl"}}, "3471": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-336"}}, "1570": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"315": {"$update": {"dna_sequence": {"$update": {"accession": "AB639410.1"}}}}}}}}, "model_name": "OprA"}, "$insert": {"CARD_short_name": "OprA"}}, "3472": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-337"}}, "2231": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3431": {"$update": {"dna_sequence": {"$update": {"accession": "KP109675.1"}}, "protein_sequence": {"$update": {"accession": "AJP77054.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CPS-1"}}, "2230": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5834": {"$update": {"dna_sequence": {"$update": {"accession": "KP109679.1"}}, "protein_sequence": {"$update": {"accession": "AJP77076.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PEDO-3"}}, "2233": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3433": {"$update": {"dna_sequence": {"$update": {"accession": "KP109676.1"}}, "protein_sequence": {"$update": {"accession": "AJP77057.1"}}}}}}}}}, "$insert": {"CARD_short_name": "MSI-1"}}, "2232": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3432": {"$update": {"dna_sequence": {"$update": {"accession": "KP109681.1"}}, "protein_sequence": {"$update": {"accession": "AJP77085.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ESP-1"}}, "2235": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5827": {"$update": {"dna_sequence": {"$update": {"accession": "KP109680.1"}}, "protein_sequence": {"$update": {"accession": "AJP77080.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SPG-1"}}, "2234": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3434": {"$update": {"dna_sequence": {"$update": {"accession": "KP109676.1"}}, "protein_sequence": {"$update": {"accession": "AJP77058.1"}}}}}}}}}, "$insert": {"CARD_short_name": "MSI-OXA"}}, "1576": {"$update": {"model_sequences": {"$update": {"sequence": {"8356": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAACATTTGCCGCATATGTAATTATCGCGTGTCTTTCGAGTACGGCATTAGCTGGTTCAATTACAGAAAATACGTCTTGGAACAAAGAGTTCTCTGCCGAAGCCGTCAATGGTGTCTTCGTGCTTTGTAAAAGTAGCAGTAAATCCTGCGCTACCAATGACTTAGCTCGTGCATCAAAGGAATATCTTCCAGCATCAACATTTAAGATCCCCAGCGCAATTATCGGCCTAGAAACTGGTGTCATAAAGAATGAGCATCAGGTTTTCAAATGGGACGGAAAGCCAAGAGCCATGAAGCAATGGGAAAGAGACTTGACCTTAAGAGGGGCAATACAAGTTTCAGCTGTTCCCGTATTTCAACAAATCGCCAGAGAAGTTGGCGAAGTAAGAATGCAGAAATACCTTAAAAAATTTTCCTATGGCAACCAGAATATCAGTGGTGGCATTGACAAATTCTGGTTGGAAGGCCAGCTTAGAATTTCCGCAGTTAATCAAGTGGAGTTTCTAGAGTCTCTATATTTAAATAAATTGTCAGCATCTAAAGAAAACCAGCTAATAGTAAAAGAGGCTTTGGTAACGGAGGCGGCACCTGAATATCTAGTGCATTCAAAAACTGGTTTTTCTGGTGTGGGAACTGAGTCAAATCCTGGTGTCGCATGGTGGGTTGGGTGGGTTGAGAAGGAGACAGAGGTTTACTTTTTCGCCTTTAACATGGATATAGACAACGAAAGTAAGTTGCCGCTAAGAAAATCCATTCCCACCAAAATCATGGAAAGTGAGGGCATCATTGGTGGCTAA", "fmax": "3517", "accession": "DQ902344.1", "fmin": "2716", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "ABI63579.1", "sequence": "MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-17"}}, "5090": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-782"}}, "1575": {"$update": {"ARO_description": "OXA-91 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1383": {"$update": {"dna_sequence": {"$update": {"accession": "DQ519086.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-91"}}, "5091": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-783"}}, "1574": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2085": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}, "ARO_category": {"$update": {"43060": {"$update": {"category_aro_description": "Genes with mutations in inhA which confer resistance to isoniazid class antibiotics."}}}}}, "$insert": {"CARD_short_name": "Mtub_inhA_INH"}}, "5092": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-784"}}, "5093": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-785"}}, "2185": {"$update": {"ARO_description": "Homologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX."}, "$insert": {"CARD_short_name": "vanM_cluster"}}, "3498": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-414"}}, "3499": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-416"}}, "3496": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-412"}}, "3497": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-413"}}, "3494": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-409"}}, "2184": {"$update": {"ARO_description": "Confers low vancomycin resistance by engineering peptidoglycan precursors ending in D-Ala-D-Ser in an inducible or constitutive manner.  The vanC cluster is intrinsic to the Enterococcus gallinarum chromosome. vanC organisms remain susceptible to teicoplanin. Gene orientation: vanC(XY)TRS."}, "$insert": {"CARD_short_name": "vanC_cluster"}}, "3492": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-407"}}, "3493": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-408"}}, "3490": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-405"}}, "3491": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-406"}}, "4570": {"$insert": {"CARD_short_name": "CTX-M-241"}}, "4571": {"$insert": {"CARD_short_name": "CTX-M-242"}}, "2097": {"$update": {"ARO_description": "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to paromomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"3238": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin"}, "$insert": {"CARD_short_name": "Ecol_16rrsB_PAR"}}, "2096": {"$update": {"ARO_description": "Point mutations in the 3' minor, 3' major, and central domains in the rrsC 16S rRNA gene of Escherichia coli can confer resistance to kasugamicin.", "model_sequences": {"$update": {"sequence": {"$update": {"3229": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrsC) mutation conferring resistance to kasugamicin"}, "$insert": {"CARD_short_name": "Ecol_16rrsC_KAS"}}, "2091": {"$update": {"ARO_description": "Point mutations in the 16S rRNA of Mycobacteroides chelonae can confer resistance to gentamicin C."}, "$insert": {"CARD_short_name": "Mche_16S_GENC"}}, "2090": {"$update": {"ARO_description": "Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to kanamycin."}, "$insert": {"CARD_short_name": "Mabs_16S_KAN"}}, "2093": {"$update": {"ARO_description": "Point mutation in the 16S rRNA helix 34 region of Chlamydophila psittaci can confer resistance against spectinomycin."}, "$insert": {"CARD_short_name": "Cpsi_16S_SPT"}}, "4607": {"$update": {"ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-17"}}, "3654": {"$update": {"ARO_description": "Point mutation in Neisseria gonorrhoea gyrase B decreases affinity to zoliflodacin antibiotic.", "model_sequences": {"$update": {"sequence": {"8367": {"dna_sequence": {"partial": "0", "sequence": "ATGACTGAACAAAAACACGAAGAATACGGCGCCGACAGCATCCAGGTGCTCGAAGGCTTGGAAGCGGTACGCAAACGCCCCGGCATGTACATCGGCGACACGCAGGACGGCAGCGGGCTGCACCATATGGTGTTTGAAGTATTGGACAACGCCATCGACGAAGCACTCGCCGGACATTGCGACAAAATCACGGTAACGATACACGCCGACCATTCCGTCAGCGTCGCCGACAACGGGCGCGGTATGCCCACCGGCATCCACCCGAAAGAAGGGCGTTCCGCCGCCGAAGTCATCATGACCGTCTTGCACGCGGGCGGCAAATTCGACAACAACAGCTACAAAATCTCCGGCGGCCTGCACGGCGTGGGCGTATCCGTCGTCAACGCGCTGTCCGACTGGGTAACGCTGACCATCTACCGCGACGGCAAAGAACACTTCGTCCGCTTCGTACGCGGCGAAACCGAAGAGCCGCTGAAAATTGTCGGCGATTCCGACAAAAAAGGCACGACCGTGCGCTTCCTCGCCGGCACGGAAACCTTCGGCAATATCGAATACAGCTTCGACATCCTCGCCAAACGTATTCGCGAACTTTCGTTCCTAAACAACGGCGTGGACATCGAATTGACCGACGAGCGCGACGGCAAGCACGAAAGCTTCGCCCTTTCCGGCGGCGTGGCGGGCTTCGTGCAATACATGAACCGCAAAAAAACGCCCTTGCACGAAAAAATCTTCTATGCGTTCGGCGAGAAAGACGGCATGAGCGTCGAATGCGCAATGCAATGGAACGACAGCTATCAGGAAAGCGTGCAGTGCTTCACCAACAACATCCCTCAGCGCGACGGCGGTACGCACCTGACCGCGCTGCGCCAAGTGATGACGCGCACCATCAACAGCTACATCGAAGCTAACGAAGTCGCCAAAAAAGCCAAAGTGGAAACCGCCGGCGACGATATGCGCGAAGGTTTGACCTGCGTGTTGTCCGTCAAACTGCCCGACCCCAAATTCTCATCCCAAACCAAAGACAAACTGGTTTCCGGCGAAATCGGCCCCGTTGTCAACGAAGTCATCAACCAAGCACTAACCGACTTCCTCGAAGAAAATCCGAACGAAGCCAAAATCATCACCGGCAAAATCGTCGATGCCGCCCGCGCACGCGAAGCCGCCCGCAAAGCCCGCGAAATCCCCCGCCGCAAAGGCGTGATGGACGGCTTGGGACTGCCCGGCAAACTCGCCGACTGCCAAGAAAAAGACCCTGCCCTGTCTGAACTCTACCTCGTCGAGGGCGACTCCGCAGGCGGTTCCGCCATGCAGGGCCGCGACCGCAAATTCCAAGCGATTTTGCCGCTCAAAGGTAAAATTTTGAACGTCGAAAAAGCACGTTTTGAAAAAATGCTCGCCAGCCAAGAGGTCGCCACCCTGATTACCGCGCTGGGTGCAGGCATCGGCAAAGAAGAGTTCAACCCTGAAAAACTACGCTACCACCGCATCATCATCATGACCGATGCCGACGTGGACGGTGCGCACATCCGCACCCTGCTCCTGACCTTCTTCTACCGCCAAATGCCCGAACTGGTCGAGCGCGGCTACATTTACATCGCCCAGCCGCCGCTCTACAAAGCCAAATACGGCAAGCAGGAGCGTTACCTCAAAGACGAACTGGAAAAAGACCAATGGCTGCTCGGCCTTGCCTTGGAAAAAGCCAAAATCGTTTCAGACGGCCGCACCATCGAAGGCGCAGAACTTGCCGACACCGCCAAACAATTCTTGTTGGCGAAAACCGTCATCGAACAGGAAAGCCGCTTCGTGGACGAACTCGTCCTGCGTGCCATGCTGCACGCGTCGCCCATTGATTTGACGTCGTCTGAAAACGCCGATAAAGCCGTTGCCGAACTTTCCGGTTTGCTTGACGAAAAAGAAGCCGCCCTCGAACGCATCGAAGGTCATGAAGGACACCAGTTCATCAAAATCACGCGCAAGCTGCACGGCAACGTCATGGTCAGCTACATCGAACCCAAGTTCCTCAACAGCAAAGCCTACCAAACCCTCACCCAAACCGCCGCCGCGCTCAAAGGCTTGGTCGGCGAGGGCGCCAAGCTCTACAAAGGCGAGAACGAGTACGACGCGGACAGCTTTGAAACCGCTTTGGACATCTTGATGAGCGTTGCCCAAAAAGGTATGTCCATCCAACGATACAAAGGTTTGGGCGAGATGAACCCCGAGCAGCTTTGGGAAACCACGATGGATCCCACCGTGCGCCGCCTGTTGAAAGTGCGCATCGAAGATGCCATTGCCGCCGACGAAGTGTTCGTTACCCTGATGGGCGACGAGGTCGAACCGCGCCGCGCCTTTATCGAAAACAATGCGCTGATTGCGCAAAATATCGACGCATAA", "fmax": "48284", "accession": "CQOZ01000008.1", "fmin": "45893", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae", "NCBI_taxonomy_id": "485", "NCBI_taxonomy_cvterm_id": "36806"}, "protein_sequence": {"accession": "CNT74515.1", "sequence": "MTEQKHEEYGADSIQVLEGLEAVRKRPGMYIGDTQDGSGLHHMVFEVLDNAIDEALAGHCDKITVTIHADHSVSVADNGRGMPTGIHPKEGRSAAEVIMTVLHAGGKFDNNSYKISGGLHGVGVSVVNALSDWVTLTIYRDGKEHFVRFVRGETEEPLKIVGDSDKKGTTVRFLAGTETFGNIEYSFDILAKRIRELSFLNNGVDIELTDERDGKHESFALSGGVAGFVQYMNRKKTPLHEKIFYAFGEKDGMSVECAMQWNDSYQESVQCFTNNIPQRDGGTHLTALRQVMTRTINSYIEANEVAKKAKVETAGDDMREGLTCVLSVKLPDPKFSSQTKDKLVSGEIGPVVNEVINQALTDFLEENPNEAKIITGKIVDAARAREAARKAREIPRRKGVMDGLGLPGKLADCQEKDPALSELYLVEGDSAGGSAMQGRDRKFQAILPLKGKILNVEKARFEKMLASQEVATLITALGAGIGKEEFNPEKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPELVERGYIYIAQPPLYKAKYGKQERYLKDELEKDQWLLGLALEKAKIVSDGRTIEGAELADTAKQFLLAKTVIEQESRFVDELVLRAMLHASPIDLTSSENADKAVAELSGLLDEKEAALERIEGHEGHQFIKITRKLHGNVMVSYIEPKFLNSKAYQTLTQTAAALKGLVGEGAKLYKGENEYDADSFETALDILMSVAQKGMSIQRYKGLGEMNPEQLWETTMDPTVRRLLKVRIEDAIAADEVFVTLMGDEVEPRRAFIENNALIAQNIDA"}}}}}, "model_param": {"$update": {"snp": {"$update": {"param_value": {"12583": "K450T", "12582": "K450N", "12584": "D429N"}, "clinical": {"12583": "K450T", "12582": "K450N", "12584": "D429N"}}}}}}, "$insert": {"CARD_short_name": "Ngon_gyrB_ZOL"}}, "4579": {"$insert": {"CARD_short_name": "DHA-26"}}, "3656": {"$update": {"model_sequences": {"$update": {"sequence": {"8366": {"dna_sequence": {"partial": "0", "sequence": "ATGGATCAATTCGCCAAAGAGACCCTGCCCACCTCCCTCGAGGAGGAAATGCGCCGTTCGTATCTCGATTACGCGATGAGCGTGATCGTCGGACGTGCCCTTCCGGATGTCCGCGATGGCCTGAAGCCCGTGCACCGGCGCGTACTGTTCGCGATGCACGAACTGAACAACGACTGGAACCGCGCGTACAAGAAATCGGCGCGTATCGTCGGCGACGTGATCGGTAAGTACCACCCGCACGGCGACACGGCGGTCTACGACACGATCGTGCGGATGGCGCAGGACTTCTCGCTGCGCTACATGCTGATCGACGGGCAGGGCAACTTCGGCTCGATCGACGGCGACAATGCGGCGGCGATGCGGTACACCGAAATTCGCATGGCGAAGATCGGGCACGAGCTGCTCGCCGACATCGACAAGGAAACGGTCGATTTCGAGCCGAACTACGACGGCAACGAAACGCAGCCGTCGGTCCTGCCGTCGCGGATCCCGAACCTGCTGATCAACGGCTCGTCGGGCATCGCCGTCGGCATGGCGACCAACATTCCGCCGCACAACCTGAACGAAGTCGTCGACGCGTGCCAGCACCTGCTGAGCAACCCCGACGCGACGGTCGACGAACTGATCGAGATCATCCCGGCGCCGGATTTCCCGACGGCCGGCATCATCTACGGCGTCGCCGGCGTGCGCGACGGCTACCGCACCGGCCGCGGCCGCGTCGTGATGCGCGCGGCCACGCACTTCGAGGAGATCGACCGCGGCCAGCGGATGGCGATCATCGTCGACGAGCTGCCGTACCAGGTCAACAAGCGCTCGCTGCTCGAGCGGATCGCCGAGCTCGTCAACGAGAAGAAGCTCGAAGGCATTTCCGATATCCGCGACGAATCCGACAAGAGCGGCATGCGGGTCGTGATCGAGCTCAAGCGCGGCGAAGTGCCGGAAGTGGTGCTGAACAACCTGTACAAGGCGACGCAGCTGCAGGACACGTTCGGCATGAACATGGTCGCGCTCGTCGACGGCCAGCCGAAGCTGCTGAACCTGAAGGAAATCCTGCAGTGCTTCCTGTCGCACCGGCGCGAAGTGCTGACGCGCCGCACGATCTACGAACTGCGCAAGGCGCGCGAGCGCGGCCACGTGCTCGAAGGTCTCGCGGTCGCGCTCGCGAACATCGACGAGTTCATCGCGATCATCAAGGCCGCGCCGACGCCGCCGATCGCGAAGCAGGAGCTGATGACGAAGTCGTGGGATTCGTCGCTCGTACGCGAGATGCTGACGCGCGCCGAATCCGAGAACGCGGCGGCGGGCGGCCGTGCCGCGTACCGTCCGGAAGGGCTGAATCCGGCGTACGGGATGCAGGCCGACGGGCTGTACAGGTTGTCCGACACGCAGGCGCAGGAAATCCTGCAGATGCGTCTGCAGCGCCTGACCGGCCTCGAGCAGGACAAGATCATCGGCGAGTATCGCGAAGTGATGGCGCAGATCGCCGATCTGCTCGACATCCTCGCGCGCCCGGAGCGCATCACGACGATGATCGGCGACGAGCTGACGACGGTGAAGGCCGAATTCGGCGATGCGCGCCGCTCGCGGATCGAGCTGAACGCGACCGAACTGAATACCGAAGACCTGATCACGCCGCAGGACATGGTCGTCACGATGTCGCATGCCGGCTACGTGAAGTCGCAGCCGCTGTCGGAGTACCGCGCGCAGAAGCGCGGCGGCCGCGGCAAGCAGGCGACGCAGATGAAGGAAGACGACTGGATCGAGACGCTCTTCATCGCGAATACGCACGACTACATGCTGTGCTTCTCGAACCGCGGTCGCGTGTACTGGATCAAGGTCTACGAGGTGCCGCAAGGTTCGCGCAACTCGCGCGGCCGTCCGATCGTCAACATGTTCCCGCTGCAGGAAGGCGAGAAGATCAACGTCGTGCTGCCGGTGAAGGAATTCTCGGCCGACAAGTTCGTGTTCATGGCGACGTCGCTCGGCACGGTCAAGAAGACGCCGCTCGAAGCGTTCAGCCGTCCGATGAAGAAGGGCATCATCGCGGTCGGCCTCGACGAGGGCGACTATCTGATCGGCGCGTCGATCACCGACGGCGCGCACGACGTGATGCTGTTCTCCGATTCGGGCAAGGCCGTGCGCTTCGACGAGAACGACGTGCGTCCGATGGGCCGCGAAGCGCGCGGCGTGCGCGGCATGCAGCTCGAGGACGGGCAGCAGGTCATCGCGCTGCTGGTCGCGGGCAGCGAGGAGCAGTCCGTGCTCACCGCAACCGAGAACGGCTTCGGCAAGCGTACGCCGATCACCGAGTACACGCGTCACGGCCGCGGCACGAAGGGTATGATCGCGATCCAGACCTCCGAGCGTAACGGCAAGGTCGTCGCTGCGACGCTCGTCGATCCGGAAGATCAGATCATGCTGATCACGACGGCCGGCGTGTTGATTCGCACGCGCGTTTCCGAGATCCGCGAGATGGGACGGGCGACGCAAGGTGTTACACTCATCAGTCTCGATGAGGGTACGAAGCTTTCGGGTCTGCAGCAGATTGCCGAGGCCGAAGAGGGCGATGGCGAAGCCGACGAGGCGTCGGACGGCGAAGCCTGA", "fmax": "2301346", "accession": "CP009795.1", "fmin": "2298742", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Burkholderia dolosa AU0158", "NCBI_taxonomy_id": "350701", "NCBI_taxonomy_cvterm_id": "42997"}, "protein_sequence": {"accession": "AJY14066.1", "sequence": "MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFEPNYDGNETQPSVLPSRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLSNPDATVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRVVMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMTKSWDSSLVREMLTRAESENAAAGGRAAYRPEGLNPAYGMQADGLYRLSDTQAQEILQMRLQRLTGLEQDKIIGEYREVMAQIADLLDILARPERITTMIGDELTTVKAEFGDARRSRIELNATELNTEDLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYMLCFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQEGEKINVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDSGKAVRFDENDVRPMGREARGVRGMQLEDGQQVIALLVAGSEEQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVDPEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEEGDGEADEASDGEA"}}}}}}, "$insert": {"CARD_short_name": "Bdol_gyrA_FLO"}}, "3657": {"$update": {"ARO_description": "New Delhi metallo-beta-lactamase-15 variant of NDM-1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-15"}}, "2099": {"$update": {"ARO_description": "Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A.", "model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A"}, "$insert": {"CARD_short_name": "Msme_16rrsB_KAN"}}, "2098": {"$update": {"model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin"}, "$insert": {"CARD_short_name": "Msme_16rrsB_VIO"}}, "3652": {"$update": {"ARO_category": {"$update": {"40636": {"$update": {"category_aro_description": "A fifth generation cephalosporin antibiotic."}}}}}, "$insert": {"CARD_short_name": "CMY-136"}}, "3653": {"$update": {"ARO_description": "Narrow-spectrum beta-lactamase isolated from several Acinetobacter spp. isolates from Argentina, as well as E. Coli. Hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SCO-1"}}, "2525": {"$insert": {"CARD_short_name": "AAC(6')-34"}}, "2524": {"$insert": {"CARD_short_name": "AAC(2')-IIb"}}, "2527": {"$insert": {"CARD_short_name": "mphI"}}, "2526": {"$update": {"ARO_category": {"$update": {"37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}, "model_name": "vgbC"}, "$insert": {"CARD_short_name": "vgbC"}}, "2521": {"$insert": {"CARD_short_name": "BahA"}}, "2520": {"$update": {"ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "CatU"}}, "2523": {"$update": {"ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "VatI"}}, "2522": {"$insert": {"CARD_short_name": "TaeA"}}, "4602": {"$update": {"ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-12"}}, "2529": {"$update": {"ARO_category": {"$update": {"41421": {"$update": {"category_aro_description": "Acetyltransferases of the cpa family confer resistance to capreomycin, an aminoglycoside antibiotic."}}}}}, "$insert": {"CARD_short_name": "cpaA"}}, "2528": {"$insert": {"CARD_short_name": "rphB"}}, "4603": {"$update": {"ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-13"}}, "472": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1720": {"$update": {"dna_sequence": {"$update": {"accession": "AY368237.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-128"}}, "4600": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6975": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "EVM-1"}}, "5639": {"$insert": {"CARD_short_name": "RSD2-1"}}, "2791": {"$insert": {"CARD_short_name": "Smit_CdsA_DAP"}}, "5575": {"$insert": {"CARD_short_name": "PDC-447"}}, "4601": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6976": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "FIA-1"}}, "4888": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-559"}}, "4889": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-560"}}, "5067": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-758"}}, "5066": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-757"}}, "5061": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-752"}}, "5060": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-751"}}, "5063": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-754"}}, "5062": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-753"}}, "2705": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "Paer_MexS_MULT"}}, "4881": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-552"}}, "2707": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "Paer_MvaT_MULT"}}, "2706": {"$insert": {"CARD_short_name": "MvaT"}}, "4884": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-555"}}, "4885": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-556"}}, "4886": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-557"}}, "4887": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-558"}}, "5574": {"$insert": {"CARD_short_name": "PDC-446"}}, "1829": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1284": {"$update": {"dna_sequence": {"$update": {"accession": "AB699171.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-87"}}, "1828": {"$update": {"ARO_description": "GES-6 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1969": {"$update": {"dna_sequence": {"$update": {"accession": "AY494718.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-6"}}, "1825": {"$update": {"ARO_description": "CTX-M-27 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1704": {"$update": {"dna_sequence": {"$update": {"accession": "AY156923.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CTX-M-27"}}, "1824": {"$update": {"model_sequences": {"$update": {"sequence": {"8246": {"dna_sequence": {"partial": "0", "sequence": "ATGACGAGCGAGCACCGCTCTGCCTCCGTGACACCCCGTCACATCTCCTTCTTCAACATCCCCGGCCACGGCCACGTGAACCCGTCACTCGGCATCGTCCAGGAACTGGTCGCGCGCGGCCACCGGGTCAGCTACGCCATCACCGACGAGTTCGCCGCACAGGTCAAGGCGGCCGGCGCGACGCCCGTGGTGTACGACTCCATCCTGCCGAAGGAGTCCAACCCCGAGGAGTCGTGGCCGGAGGACCAGGAGTCCGCGATGGGCCTGTTCCTCGACGAAGCCGTCCGGGTCCTGCCGCAGCTGGAGGACGCCTACGCCGACGACCGGCCGGACCTGATCGTCTACGACATCGCCTCCTGGCCCGCCCCGGTGCTCGGCCGGAAGTGGGACATCCCCTTCGTCCAGCTCTCCCCGACCTTCGTCGCCTACGAGGGCTTCGAGGAGGACGTACCCGCGGTGCAGGACCCCACGGCCGACCGCGGCGAGGAGGCCGCCGCCCCCGCGGGGACCGGGGACGCCGAGGAGGGTGCCGAGGCCGAGGACGGCCTGGTGCGCTTCTTCACCCGGCTCTCGGCCTTCCTGGAGGAGCACGGGGTGGACACCCCGGCCACCGAGTTCCTCATCGCGCCCAACCGCTGCATCGTCGCGCTGCCGCGCACCTTCCAGATCAAGGGCGACACGGTCGGCGACAACTACACCTTCGTCGGTCCCACCTACGGCGACCGGTCCCACCAGGGCACCTGGGAAGGCCCCGGGGACGGGCGTCCGGTGCTGCTGATCGCCCTGGGCTCGGCGTTCACCGACCACCTCGACTTCTACCGCACCTGCCTGTCCGCCGTCGACGGCCTGGACTGGCACGTGGTGCTCTCCGTGGGCCGCTTCGTCGACCCCGCGGACCTCGGCGAGGTCCCGCCGAACGTCGAGGTGCACCAGTGGGTGCCGCAGCTCGACATCCTGACCAAAGCCTCCGCGTTCATCACGCACGCGGGCATGGGCAGCACCATGGAGGCCCTGTCGAACGCGGTGCCCATGGTCGCGGTGCCGCAGATCGCGGAGCAGACGATGAACGCCGAGCGGATCGTCGAGCTGGGCCTCGGCCGGCACATCCCGCGGGACCAGGTCACGGCCGAGAAGCTGCGCGAGGCCGTGCTCGCCGTCGCCTCCGACCCCGGTGTCGCCGAACGGCTCGCGGCCGTCCGGCAGGAGATCCGTGAGGCGGGCGGCGCCCGGGCGGCCGCCGACATCCTGGAGGGCATCCTCGCCGAAGCAGGCTGA", "fmax": "1275", "accession": "DQ195535.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces antibioticus", "NCBI_taxonomy_id": "1890", "NCBI_taxonomy_cvterm_id": "36823"}, "protein_sequence": {"accession": "ABA42118.2", "sequence": "MTSEHRSASVTPRHISFFNIPGHGHVNPSLGIVQELVARGHRVSYAITDEFAAQVKAAGATPVVYDSILPKESNPEESWPEDQESAMGLFLDEAVRVLPQLEDAYADDRPDLIVYDIASWPAPVLGRKWDIPFVQLSPTFVAYEGFEEDVPAVQDPTADRGEEAAAPAGTGDAEEGAEAEDGLVRFFTRLSAFLEEHGVDTPATEFLIAPNRCIVALPRTFQIKGDTVGDNYTFVGPTYGDRSHQGTWEGPGDGRPVLLIALGSAFTDHLDFYRTCLSAVDGLDWHVVLSVGRFVDPADLGEVPPNVEVHQWVPQLDILTKASAFITHAGMGSTMEALSNAVPMVAVPQIAEQTMNAERIVELGLGRHIPRDQVTAEKLREAVLAVASDPGVAERLAAVRQEIREAGGARAAADILEGILAEAG"}}}}}}, "$insert": {"CARD_short_name": "oleI"}}, "1827": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1149": {"$update": {"dna_sequence": {"$update": {"accession": "X55640.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-5"}}, "1826": {"$update": {"ARO_description": "ykkC is an SMR-type protein that is a subunit of the ykkCD efflux pump.", "model_sequences": {"$update": {"sequence": {"$update": {"489": {"$update": {"dna_sequence": {"$update": {"accession": "AL009126.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ykkC"}}, "1821": {"$update": {"ARO_description": "AAC(6')-Ir is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter colistiniresistens.", "model_sequences": {"$update": {"sequence": {"$update": {"581": {"$update": {"dna_sequence": {"$update": {"accession": "AF031326.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ir"}}, "1820": {"$insert": {"CARD_short_name": "bacA"}}, "4402": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6777": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-6"}}, "4403": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-7"}}, "928": {"$update": {"ARO_description": "carA is an ABC-F subfamily protein involved in macrolide resistance. It is found in Streptomyces thermotolerans.", "model_sequences": {"$update": {"sequence": {"$update": {"90": {"$update": {"dna_sequence": {"$update": {"accession": "M80346.1"}}}}}}}}}, "$insert": {"CARD_short_name": "carA"}}, "929": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1670": {"$update": {"dna_sequence": {"$update": {"accession": "FJ820124.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-10"}}, "2145": {"$update": {"ARO_description": "Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline.", "model_sequences": {"$update": {"sequence": {"$update": {"3242": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline"}, "$insert": {"CARD_short_name": "Ecol_16rrsB_TET"}}, "2412": {"$update": {"ARO_description": "Point mutation in parC conferring resistance to fluoroquinolone antibiotics in Shigella flexneri,."}, "$insert": {"CARD_short_name": "Sfle_parC_FLO"}}, "2143": {"$update": {"ARO_description": "Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to gentamicin."}, "$insert": {"CARD_short_name": "Bbur_16S_GEN"}}, "2142": {"$update": {"model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin"}, "$insert": {"CARD_short_name": "Msme_16rrsA_VIO"}}, "2141": {"$update": {"ARO_description": "Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to neomycin.", "model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin"}, "$insert": {"CARD_short_name": "Msme_16rrsB_NEO"}}, "2140": {"$update": {"ARO_description": "Point mutations in the 5' domain of helix 18, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"3231": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin"}, "$insert": {"CARD_short_name": "Ecol_16rrsB_STR"}}, "920": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1074": {"$update": {"dna_sequence": {"$update": {"accession": "DQ834728.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-152"}}, "921": {"$update": {"ARO_description": "OKP-A-11 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8242": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGCATTCGCCAGCCCTCCGCCGCTCGAGCAAGTTACACGCAGCGAAAGTCAGCTGGCGGGCCGCGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGAGACGAACAGCTGGATCGGCGGATCCGCTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTTGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAGCTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCAGCCAGCATGGCCGCCACCCTGCGCAAGCTGCTAACCAGCCACGCGCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCAGGTGGCCGGTCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGCGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGAACGGCAAAGCGGAGCGCATCGTGGTGATCTATCTGCGGGATACGCCGGCGACCATGGCCGAGCGTAACCAGCAGATCGCCAGAATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "880", "accession": "AM850915.2", "fmin": "19", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12353.2", "sequence": "MRYVRLCLISLIAALPLAAFASPPPLEQVTRSESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIRYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMAATLRKLLTSHALSARSQQQLLQWMVDDQVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPNGKAERIVVIYLRDTPATMAERNQQIARIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-11"}}, "922": {"$update": {"ARO_description": "AAC(6')-30/AAC(6')-Ib' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"8193": {"dna_sequence": {"partial": "0", "sequence": "ATGACATTCCTGATCCGACCCGTAGAACAAAGTGACGCTGAATCTTGGGAGCGCTTACGCAACCTTTTGTGGGAGGGCGACGACCACAAAAGCGAGATCACACAATTCTTCAACGGCGAAGTAGAAGAACCCAATGAAGTGTTGCTTGCCGTAACCGAAGAAAATGATGCAATAGCGCACATCGAGCTATCGTTGAGGTATGACATTGATGGCTTGACGGGCATCAAGACCGGTTACATCGAAGGCCTTTTTGTAGAGGAGCGGCACCGTGCCGCAGGTGTAGTCCTCAAGCTATTGCGAGCCGCAGAGTTCTGGGCAAGAGATCAAGGATGTCTGGCGTTTGCCTCAGACAGGGATGATCGTGTCATCATCTATGCTCGCTACACGGGAGCGCCACCTAACAATTCATTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "fmax": "2913", "accession": "AJ584652.2", "fmin": "1926", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "CAE48335.2", "sequence": "MTFLIRPVEQSDAESWERLRNLLWEGDDHKSEITQFFNGEVEEPNEVLLAVTEENDAIAHIELSLRYDIDGLTGIKTGYIEGLFVEERHRAAGVVLKLLRAAEFWARDQGCLAFASDRDDRVIIYARYTGAPPNNSLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA"}}}}}}, "$insert": {"CARD_short_name": "AAC6_30_AAC6_Ib"}}, "923": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1890": {"$update": {"dna_sequence": {"$update": {"accession": "HM750249.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-25"}}, "4970": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-645"}}, "4971": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-650"}}, "2149": {"$update": {"model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B"}, "$insert": {"CARD_short_name": "Msme_16rrsA_HGM"}}, "4973": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-652"}}, "5393": {"$insert": {"CARD_short_name": "PDC-254"}}, "5392": {"$insert": {"CARD_short_name": "PDC-253"}}, "5391": {"$insert": {"CARD_short_name": "PDC-252"}}, "5390": {"$insert": {"CARD_short_name": "PDC-251"}}, "5397": {"$insert": {"CARD_short_name": "PDC-260"}}, "5396": {"$insert": {"CARD_short_name": "PDC-26"}}, "5395": {"$insert": {"CARD_short_name": "PDC-259"}}, "5394": {"$insert": {"CARD_short_name": "PDC-256"}}, "2411": {"$insert": {"CARD_short_name": "Sfle_gyrA_FLO"}}, "5399": {"$insert": {"CARD_short_name": "PDC-262"}}, "5398": {"$insert": {"CARD_short_name": "PDC-261"}}, "4326": {"$insert": {"CARD_short_name": "ADC-33"}}, "1920": {"$update": {"ARO_description": "Also known as vanSF, is a vanS variant found in the vanF gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"680": {"$update": {"dna_sequence": {"$update": {"accession": "AF155139.1"}}}}}}}}, "model_name": "vanS gene in vanF cluster", "ARO_name": "vanS gene in vanF cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanF_cl"}}, "1921": {"$insert": {"CARD_short_name": "EreB"}}, "1922": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "marA"}}, "1923": {"$update": {"ARO_description": "APH(3'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus.", "model_sequences": {"$update": {"sequence": {"$update": {"91": {"$update": {"dna_sequence": {"$update": {"accession": "X53527.1"}}}}}}}}, "ARO_category": {"$update": {"36266": {"$update": {"category_aro_description": "Phosphorylation of streptomycin on the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "APH(3'')-Ia"}}, "1924": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"651": {"$update": {"dna_sequence": {"$update": {"accession": "FJ349556.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanM"}}, "1925": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"113": {"$update": {"dna_sequence": {"$update": {"accession": "L11616.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MexB"}}, "1926": {"$update": {"ARO_description": "CMY-34 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1993": {"$update": {"dna_sequence": {"$update": {"accession": "EF394370.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-34"}}, "1927": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2024": {"$update": {"dna_sequence": {"$update": {"accession": "AF301532.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-29"}}, "1928": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1935": {"$update": {"dna_sequence": {"$update": {"accession": "AY306130.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-50"}}, "1929": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"779": {"$update": {"dna_sequence": {"$update": {"accession": "KJ207207.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-24"}}, "4226": {"$insert": {"CARD_short_name": "ADC-156"}}, "3278": {"$update": {"ARO_description": "AbaQ is an MFS transporter mainly involved in the extrusion of quinolone-type drugs in A. baumannii."}, "$insert": {"CARD_short_name": "Abau_AbaQ"}}, "3474": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-340"}}, "3475": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-341"}}, "830": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1635": {"$update": {"dna_sequence": {"$update": {"accession": "JX121124.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-157"}}, "831": {"$update": {"ARO_description": "OKP-B-13 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1041": {"$update": {"dna_sequence": {"$update": {"accession": "AY825330.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-13"}}, "836": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1327": {"$update": {"dna_sequence": {"$update": {"accession": "AJ239002.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-68"}}, "837": {"$update": {"ARO_description": "vatH is a plasmid-mediated acetyltransferase found in Enterococcus faecium.", "model_sequences": {"$update": {"sequence": {"8208": {"dna_sequence": {"partial": "0", "sequence": "ATGGCAGAAAAATTAAAAGGACCCAACTCAAATGAAATGTATCCGATTGCCGGAAATAAAAGTGTTCAATTTGTTAAACCGTCATTAACAAGGCCCAATATTATAGTTGGTGAGTTCACTTATTATGATAGCAAGAACGGAGAGCTTTTTGAGGATCAAGTTCTGTATCATTATGAAATTATAGGGGATCGACTGATCATCGGGAAATTTTGTTCAATCGGTCCTGGAGTCACTTTTATTATGAATGGAGCTAATCATCGCATGGATGGCTCCACTTATCCATTTAATATCTTTGGGCATGGGTGGGAAAAGCATACACCTACACTAGATATGCTGCCTTTAAAGGGGGATACTATTGTTGGTAATGACGTATGGATTGGACTAGATGCTACAATTATGCCAGGCGTAAAAATAGGAGACGGCGCGATTATTGCAGCCAAATCTGTAGTAACAAAAGACGTTGACCCCTCCACAATTGTTGGTGGTAATCCTGCAAAACAAATAAAGAAACGATTTTCGGAGTCAAAAATTCAAGAACTATTAAAGATAAAATGGTGGGATTTTGAAGACCAGGTTATTAGCGATAATATTGATGCTATTCTAAGTTTGGATGTTGAAGCGCTTAATAATATTTCTAAAGAAAATGATTAG", "fmax": "3687", "accession": "GQ205627.2", "fmin": "3036", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"accession": "ACX92987.1", "sequence": "MAEKLKGPNSNEMYPIAGNKSVQFVKPSLTRPNIIVGEFTYYDSKNGELFEDQVLYHYEIIGDRLIIGKFCSIGPGVTFIMNGANHRMDGSTYPFNIFGHGWEKHTPTLDMLPLKGDTIVGNDVWIGLDATIMPGVKIGDGAIIAAKSVVTKDVDPSTIVGGNPAKQIKKRFSESKIQELLKIKWWDFEDQVISDNIDAILSLDVEALNNISKEND"}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vatH"}}, "834": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"540": {"$update": {"dna_sequence": {"$update": {"accession": "JF411006.1"}}}}}}}}}, "$insert": {"CARD_short_name": "FosA3"}}, "3473": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-339"}}, "4220": {"$insert": {"CARD_short_name": "ADC-150"}}, "838": {"$update": {"ARO_description": "CTX-M-102 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"946": {"$update": {"dna_sequence": {"$update": {"accession": "HQ398215.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-102"}}, "839": {"$update": {"ARO_description": "CMY-44 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1586": {"$update": {"dna_sequence": {"$update": {"accession": "FJ437066.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-44"}}, "3478": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-344"}}, "3479": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-345"}}, "4221": {"$insert": {"CARD_short_name": "ADC-151"}}, "3": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics"}, "$insert": {"CARD_short_name": "Ecol_ompF_BLA"}}, "4222": {"$insert": {"CARD_short_name": "ADC-152"}}, "4248": {"$insert": {"CARD_short_name": "ADC-180"}}, "4622": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-39"}}, "4223": {"$insert": {"CARD_short_name": "ADC-153"}}, "671": {"$update": {"ARO_description": "CTX-M-137 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"785": {"$update": {"dna_sequence": {"$update": {"accession": "AB900900.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-137"}}, "1986": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1131": {"$update": {"dna_sequence": {"$update": {"accession": "HF947514.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-309"}}, "5586": {"$insert": {"CARD_short_name": "PDC-459"}}, "3956": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumonia. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-223"}}, "2178": {"$update": {"ARO_description": "Homologous to vanA, contains a D-Ala-D-Lac ligase. The chromosome-located vanO gene cluster is inducible. Not much is known about the biochemistry about the vanO gene cluster. Gene orientation: orf1 RS orf2 HOX."}, "$insert": {"CARD_short_name": "vanO_cluster"}}, "5587": {"$insert": {"CARD_short_name": "PDC-46"}}, "2794": {"$update": {"ARO_description": "Point mutations in Helicobacter pylori shown to confer resistance to clarithromycin, a macrolide antibiotic.", "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"12514": "A2143G", "12515": "A1410G", "12516": "A2167G", "12517": "C1707T", "12518": "C2922T"}}, "clinical": {"$insert": {"12514": "A2143G", "12515": "A1410G", "12516": "A2167G", "12517": "C1707T", "12518": "C2922T"}}}}}, "$insert": {"40330": {"param_value": {"12519": "C2248T,G2287A"}, "param_type_id": "40330", "param_type": "multiple resistance variants", "param_description": "A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms."}}}}, "$insert": {"CARD_short_name": "Hpyl_23S_CLR"}}, "3868": {"$insert": {"CARD_short_name": "PDC-44"}}, "5584": {"$insert": {"CARD_short_name": "PDC-457"}}, "3941": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6304": {"$update": {"dna_sequence": {"$update": {"accession": "KY066478.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-144"}}, "3319": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5297": {"$update": {"dna_sequence": {"$update": {"accession": "AP014611.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ian"}}, "3318": {"$update": {"ARO_description": "An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii."}, "$insert": {"CARD_short_name": "ADC-60"}}, "5585": {"$insert": {"CARD_short_name": "PDC-458"}}, "5421": {"$insert": {"CARD_short_name": "PDC-289"}}, "5489": {"$insert": {"CARD_short_name": "PDC-36"}}, "5488": {"$insert": {"CARD_short_name": "PDC-359"}}, "5487": {"$insert": {"CARD_short_name": "PDC-358"}}, "5486": {"$insert": {"CARD_short_name": "PDC-357"}}, "3313": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-8"}}, "5484": {"$insert": {"CARD_short_name": "PDC-355"}}, "5483": {"$insert": {"CARD_short_name": "PDC-354"}}, "5482": {"$insert": {"CARD_short_name": "PDC-353"}}, "5481": {"$insert": {"CARD_short_name": "PDC-351"}}, "5480": {"$insert": {"CARD_short_name": "PDC-350"}}, "784": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"81": {"$update": {"dna_sequence": {"$update": {"accession": "AF031330.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iv"}}, "785": {"$update": {"ARO_description": "OXY-2-9 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1770": {"$update": {"dna_sequence": {"$update": {"accession": "FJ785625.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-9"}}, "786": {"$update": {"ARO_description": "Also known as vanHO, is a vanH variant in the vanO gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"576": {"$update": {"dna_sequence": {"$update": {"accession": "KF478993.1"}}}}}}}}, "model_name": "vanH gene in vanO cluster", "ARO_name": "vanH gene in vanO cluster"}, "$insert": {"CARD_short_name": "vanH_in_vanO_cl"}}, "787": {"$update": {"ARO_description": "dfrA23 is an integron-encoded dihydrofolate reductase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"8173": {"dna_sequence": {"partial": "0", "sequence": "ATGCCAACAGTTGAGATTATTGTTGCAGTTGATCCTGTTGGGGGATTTGGCCGGAATGGCCAAATCCCTTGGACGTGCAAGGAAGACATGAAGCGCTTCACCACCATATCCAAAGAGATTCGAGTGTGTGTGATGGGGAAGAACACATACAAAGACATGCTCGATATGCAAATGAAGAAGGAAGGCGCTGAAGAACGAATCAAAGAGAAGGGAATTCTTCCGGAGCGCGAATCTTACGTCGTGTCCTCGACTTTGAAGCCCGAGGACGTCATTGGAGCCACGGTAGTTCCGGACCTACGTGCGGTGCTCAATCAATATCACGACAGCGATCAACGAATAGCTGTCATTGGTGGAGAAAAGCTGTACGTGCAAGCCCTCGCATCTGCCACAAAAGTCCACATGACGGTAATGCACAAGCCATATAACTGCGATCGGACGTTGCCGATGTCATACATCGACAAAAAGTTTGTTGCAGGTCAAGGGTCTATCACCATTCAAACTGCGGTAGATGGTGAGACCCATCCCGTGAAGTTCATCACATATGAGCGCGCTCGGCCGTAA", "fmax": "7303", "accession": "AJ746361.2", "fmin": "6742", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Typhimurium", "NCBI_taxonomy_id": "90371", "NCBI_taxonomy_cvterm_id": "35732"}, "protein_sequence": {"accession": "CAG34233.2", "sequence": "MPTVEIIVAVDPVGGFGRNGQIPWTCKEDMKRFTTISKEIRVCVMGKNTYKDMLDMQMKKEGAEERIKEKGILPERESYVVSSTLKPEDVIGATVVPDLRAVLNQYHDSDQRIAVIGGEKLYVQALASATKVHMTVMHKPYNCDRTLPMSYIDKKFVAGQGSITIQTAVDGETHPVKFITYERARP"}}}}}}, "$insert": {"CARD_short_name": "dfrA23"}}, "5249": {"$insert": {"CARD_short_name": "PDC-111"}}, "781": {"$update": {"ARO_description": "QnrB25 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"73": {"$update": {"dna_sequence": {"$update": {"accession": "HQ172108.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB25"}}, "782": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1615": {"$update": {"dna_sequence": {"$update": {"accession": "AY619003.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-63"}}, "783": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4450": {"$update": {"dna_sequence": {"$update": {"accession": "FN396876.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-1"}}, "1726": {"$update": {"ARO_description": "FOX-4 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1189": {"$update": {"dna_sequence": {"$update": {"accession": "AJ277535.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-4"}}, "1727": {"$update": {"model_sequences": {"$update": {"sequence": {"8211": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAATTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGTAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAGGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "874", "accession": "AM176548.2", "fmin": "16", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47128.2", "sequence": "MRIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-73"}}, "1724": {"$update": {"ARO_description": "Also known as vanHM, is a vanH variant in the vanM gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"534": {"$update": {"dna_sequence": {"$update": {"accession": "FJ349556.1"}}}}}}}}, "model_name": "vanH gene in vanM cluster", "ARO_name": "vanH gene in vanM cluster"}, "$insert": {"CARD_short_name": "vanH_in_vanM_cl"}}, "5246": {"$insert": {"CARD_short_name": "PDC-108"}}, "788": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"919": {"$update": {"dna_sequence": {"$update": {"accession": "AY210887.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-46"}}, "789": {"$update": {"ARO_description": "IMP-43 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"791": {"$update": {"dna_sequence": {"$update": {"accession": "AB777500.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-43"}}, "1720": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"75": {"$update": {"dna_sequence": {"$update": {"accession": "AJ000283.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tap"}}, "1721": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2070": {"$update": {"dna_sequence": {"$update": {"accession": "AL450380.1"}}}}}}}}, "ARO_category": {"$update": {"39972": {"$update": {"category_aro_description": "Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Thus acts as a competitive inhibitor of folP. Point mutation within the folP gene results in lowered affinity of dapsone for folP."}}}}}, "$insert": {"CARD_short_name": "Mlep_folP_DAO"}}, "5627": {"$insert": {"CARD_short_name": "PLA-3"}}, "2361": {"$insert": {"CARD_short_name": "ADC-56"}}, "4711": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-88"}}, "5626": {"$insert": {"CARD_short_name": "PLA-2a"}}, "5625": {"$insert": {"CARD_short_name": "PLA-1"}}, "3954": {"$update": {"ARO_description": "A beta-lactamase gene found in Escherichia coli. Directly submitted to NCBI without publication on 10-AUG-2017.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-199"}}, "3330": {"$update": {"model_name": "Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Mgen_gyrA_FLO"}}, "5624": {"$insert": {"CARD_short_name": "PFM-3"}}, "5623": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7998": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "PFM-2"}}, "1042": {"$update": {"ARO_description": "catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Paer_catB7"}}, "925": {"$update": {"ARO_description": "AAC(3)-IIb is an aminoglycoside acetyltransferase in E. coli, A. faecalis and S. marcescens.", "model_sequences": {"$update": {"sequence": {"$update": {"10": {"$update": {"dna_sequence": {"$update": {"accession": "M97172.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-IIb"}}, "60": {"$update": {"ARO_description": "QnrS6 is a plasmid-mediated quinolone resistance protein found in Aeromonas hydrophila.", "model_sequences": {"$update": {"sequence": {"$update": {"296": {"$update": {"dna_sequence": {"$update": {"accession": "HQ631376.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS6"}}, "3311": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-38"}}, "62": {"$update": {"ARO_description": "CMY-42 is a plasmid-borne AmpC cephalosporinase gene found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1422": {"$update": {"dna_sequence": {"$update": {"accession": "HM146927.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-42"}}, "63": {"$update": {"ARO_description": "AAC(6')-Ib is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in K. pneumoniae, P. mirabilis, P. aeruginosa, S. enterica, K. oxytoca, S. maltophilia, E. cloacae and V. cholerae.", "model_sequences": {"$update": {"sequence": {"$update": {"231": {"$update": {"dna_sequence": {"$update": {"accession": "JQ808129.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ib"}}, "64": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1180": {"$update": {"dna_sequence": {"$update": {"accession": "JX440350.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-70"}}, "5621": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-9"}}, "66": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1790": {"$update": {"dna_sequence": {"$update": {"accession": "AF535129.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-41"}}, "3310": {"$update": {"ARO_description": "ADC-11 is a class C beta-lactamase found in Acinetobacter baumannii."}, "$insert": {"CARD_short_name": "ADC-11"}}, "68": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2031": {"$update": {"dna_sequence": {"$update": {"accession": "AY491682.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-132"}}, "69": {"$update": {"ARO_description": "aadA23 is an integron-encoded aminoglycoside nucleotidyltransferase gene in S. enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"280": {"$update": {"dna_sequence": {"$update": {"accession": "AJ809407.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA23"}}, "5620": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-8"}}, "5485": {"$insert": {"CARD_short_name": "PDC-356"}}, "5635": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8010": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "PSV-1"}}, "1371": {"$update": {"ARO_description": "CTX-M-26 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1628": {"$update": {"dna_sequence": {"$update": {"accession": "AY157676.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-26"}}, "1588": {"$update": {"ARO_description": "QnrB50 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"298": {"$update": {"dna_sequence": {"$update": {"accession": "JX440357.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB50"}}, "3312": {"$insert": {"CARD_short_name": "Mgen_23S_MULT"}}, "1370": {"$update": {"ARO_description": "AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"314": {"$update": {"dna_sequence": {"$update": {"accession": "U59183.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ib10"}}, "1582": {"$update": {"ARO_description": "dfrA5 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae.", "model_sequences": {"$update": {"sequence": {"$update": {"2104": {"$update": {"dna_sequence": {"$update": {"accession": "DQ278190.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA5"}}, "3315": {"$update": {"ARO_description": "An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii."}, "$insert": {"CARD_short_name": "ADC-30"}}, "1580": {"$update": {"ARO_description": "catIII is a plasmid-encoded variant of the cat gene found in Shigella flexneri.", "model_sequences": {"$update": {"sequence": {"$update": {"528": {"$update": {"dna_sequence": {"$update": {"accession": "X07848.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catIII"}}, "1581": {"$update": {"ARO_description": "ACT-3 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1177": {"$update": {"dna_sequence": {"$update": {"accession": "EF125013.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-3"}}, "1586": {"$update": {"ARO_description": "CTX-M-32 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"867": {"$update": {"dna_sequence": {"$update": {"accession": "AJ557142.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-32"}}, "1373": {"$update": {"ARO_description": "CMY-26 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1361": {"$update": {"dna_sequence": {"$update": {"accession": "AB300358.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-26"}}, "1584": {"$insert": {"CARD_short_name": "tet(41)"}}, "3314": {"$insert": {"CARD_short_name": "ADC-10"}}, "2433": {"$update": {"model_name": "lfrA"}, "$insert": {"CARD_short_name": "lfrA"}}, "1038": {"$update": {"ARO_description": "cmlB1 is a plasmid-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica.", "model_sequences": {"$update": {"sequence": {"$update": {"731": {"$update": {"dna_sequence": {"$update": {"accession": "AM296481.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cmlB1"}}, "404": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1455": {"$update": {"dna_sequence": {"$update": {"accession": "JN603240.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-217"}}, "3317": {"$update": {"ARO_description": "An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii."}, "$insert": {"CARD_short_name": "ADC-59"}}, "508": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"30": {"$update": {"dna_sequence": {"$update": {"accession": "L20800.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tetA(P)"}}, "2432": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}}, "$insert": {"CARD_short_name": "Kpne_OmpK35"}}, "1032": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"976": {"$update": {"dna_sequence": {"$update": {"accession": "KF885217.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-365"}}, "403": {"$update": {"ARO_description": "dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"568": {"$update": {"dna_sequence": {"$update": {"accession": "KJ174469.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA8"}}, "1030": {"$update": {"ARO_description": "Also known as vanZA, is a vanZ variant found in the vanA gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3280": {"$update": {"dna_sequence": {"$update": {"accession": "M97297.1"}}}}}}}}, "model_name": "vanZ gene in vanA cluster", "ARO_name": "vanZ gene in vanA cluster"}, "$insert": {"CARD_short_name": "vanZ_in_vanA_cl"}}, "3316": {"$update": {"ARO_description": "An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii."}, "$insert": {"CARD_short_name": "ADC-58"}}, "502": {"$update": {"ARO_description": "aadA17 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Aeromonas media.", "model_sequences": {"$update": {"sequence": {"8152": {"dna_sequence": {"partial": "0", "sequence": "ATGAGGGTAGCGGTGACCATCGAAATTTCGAACCAACTATCAGAGGTGCTAAGCGTCATCGAGCGCCATCTCGAACCGACGTTGCTGGCCGTACATTTGTACGGCTCCGCAGTGGATGGCGGCCTGAAGCCACACAGTGATATTGATTTGCTGGTTACGGTGACCGTAAGGCTTGATGAAACAACGCGGCGAGCTTTGATCAACGACCTTTTGGAAACTTCGGCTTCCCCTGGAGAGAGCGAGATTCTCCGCGCTGTAGAAGTCACCATTGTTGTGCACGACGACATCATTCCGTGGCGTTATCCAGCTAAGCGCGAACTGCAATTTGGAGAATGGCAGCGCAATGACATTCTTGCAGGTATCTTCGAGCCAGCCACGATCGACATTGATCTAGCTATCCTGCTTACAAAAGCAAGAGAACATAGCGTTGCCTTGGTAGGTCCGGCAGCGGAGGAATTCTTTGACCCGGTTCCTGAACAGGATCTATTCGAGGCGCTGAGGGAAACCTTGAAGCTATGGAACTCGCAGCCCGACTGGGCCGGCGATGAGCGAAATGTAGTGCTTACGTTGTCCCGCATTTGGTACAGCGCAATAACCGGCAAAATCGCGCCGAAGGATGTCGCTGCCGACTGGGCAATAAAACGCCTACCTGCCCAGTATCAGCCCGTCTTACTTGAAGCTAAGCAAGCTTATCTGGGACAAAAAGAAGATCACTTGGCCTCACGCGCAGATCACTTGGAAGAATTTATTCGCTTTGTGAAAGGCGAGATCATCAAGTCAGTTGGTAAATGA", "fmax": "2582", "accession": "FJ460181.2", "fmin": "1790", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Aeromonas media", "NCBI_taxonomy_id": "651", "NCBI_taxonomy_cvterm_id": "39526"}, "protein_sequence": {"accession": "ACK43806.1", "sequence": "MRVAVTIEISNQLSEVLSVIERHLEPTLLAVHLYGSAVDGGLKPHSDIDLLVTVTVRLDETTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPATIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLFEALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQPVLLEAKQAYLGQKEDHLASRADHLEEFIRFVKGEIIKSVGK"}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA17"}}, "503": {"$update": {"ARO_description": "CTX-M-69 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1353": {"$update": {"dna_sequence": {"$update": {"accession": "EU402393.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-69"}}, "500": {"$update": {"ARO_description": "OXA-164 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1125": {"$update": {"dna_sequence": {"$update": {"accession": "GU831575.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-164"}}, "501": {"$update": {"ARO_description": "AAC(3)-VIIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces fradiae.", "model_sequences": {"$update": {"sequence": {"$update": {"12": {"$update": {"dna_sequence": {"$update": {"accession": "M55426.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-VIIIa"}}, "1212": {"$update": {"ARO_description": "OXA-141 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1124": {"$update": {"dna_sequence": {"$update": {"accession": "EF552405.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-141"}}, "1213": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "nalD"}}, "1210": {"$update": {"model_sequences": {"$update": {"sequence": {"8215": {"dna_sequence": {"partial": "0", "sequence": "ATGAAGTCCGCACTCTCGACCTGGAAGCCCTCGGACCGGCCGCCGGATCCGACACTGCCCGAGCCGCCGGCCCAGCTGCGCCGCATCTTCCGGCTCTTCCGCCCGTACCGCGGCAGGCTCGCCGTCGTCGGCCTGCTCGTCGGCGCCTCGTCGCTGGTGGCCGTCGCCTCGCCGTTCATGCTGCGCGAGATCCTCGACACCGCGATCCCGCAGGGCCGCACCGGGCTGCTCAGCCTGCTCGCCCTCGGCATGATCCTGACCGCCGTCCTCAGCAGCGTCTTCGGCGTCGTCCAGACCCTCATCTCCACGACGGTCGGCCAGCGCGTCATGCACGACCTGCGCACCGCCGTCTACGCGCAGCTCCAGCGCATGCCCCTCGCGTTCTTCACCCGCACCCGCACCGGTGAGGTCCAGTCCCGGATAGCCAACGACATCGGCGGCATGCAGGCGACCGTCACCTCAACCGCCACGTCGCTGGTCTCCAACCTCACCGCCGTCATCGCCACCGTCGTCGCGATGCTCGCGCTGGACTGGCGGCTGACCGTCGTCTCGCTGCTCCTGCTGCCGGTGTTCGTCTGGATCAGCCGCCGCGTCGGCCGTGAGCGCAAACGGATCACCCTGCAACGGCAGAAGCAGATGGCCACGATGGCCGCCACGGTCACGGAGTCGCTGTCGGTCAGCGGCATCCTCCTCGGCCGCACGATGGGGCGCGCCGACTCGCTCACCAGATCCTTCGCCGAGGAGTCCGAGCGACTCGTCGACCTGGAGGTCCGCTCCAACATGGCCGGGCGGTGGCGGATGTCCGTCATCGGCATCGTCATGGCCGCCATGCCCGCCGTCATCTACTGGGCGGCCGGCTTCGTCCTCCAGTCCGGCGGCACGGTCGTCTCCATCGGCACACTCGTCGCCTTCGTCTCCCTCCAGCAGGGCCTCTTCCGCCCGGCCGTGAGCCTGCTCGCCACCGGCGTGCAGATGCAGACGTCCCTCGCGCTCTTCCAGCGCATCTTCGAATATCTCGACCTGCCCGTCGACATCACCGAACCCGAGCGTCCGGTGGCCCTCGACAAGGTCCGGGGCGAAGTGCGCTTCGACGGCGTCGACTTCAGTTACGAGGAGAAGGACGGCAACACCCTCCACGGCCTGGATCTGACCGTCCCGGCCGGCGGCAGCCTCGCCGTCGTCGGTCCCACCGGATCGGGCAAGTCGACCCTGAGCTATCTCGTGCCGCGTCTGTACGACGTGACGGGCGGCCGGGTCCTGCTCGACGGCGTCGACGTACGCGACCTGGCCTTCGACACCCTCGCCCGCGCGGTGGGCGTCGTGTCGCAGGAGACGTATCTCTTCCACGCCTCCGTCGCCGACAACCTCCGCTTCGCCAAACCGGACGCGACGGACGAGGAGATCGAGAAGGCGGCCAGGGCCGCCCAGATCCACGAGCACATCGTCACCCTGCCCGACGGGTACGACACACTGGTCGGCGAGCGCGGATACCGGTTCTCCGGCGGCGAGAAACAGCGCCTCGCGATCGCCCGCACCATCCTGCGCGACCCGCCCGTCCTCGTGCTGGACGAGGCGACGAGCGCGCTCGACACCCGTACCGAACACGCGGTCCAGCAGGCCATCGACTCCCTCTCCGAGGGCCGTACGACCATCACCATCGCCCACCGGCTCTCCACGGTGCGCGACGCCGACCAGATCGTCGTCCTCGACGCCGGTCGCATAGCCGAGCGCGGCACGCACGAGGAGCTGATCGACCGGGACGGCAGGTACGCGGCGCTCGTCCGCCGGGACGGCGCGCCGGCGCCCGCGCCCGTGCCCGCCCGGGACGAGCGCGTGGGCGCCGCCTGA", "fmax": "1848", "accession": "AF170880.4", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptomyces niveus", "NCBI_taxonomy_id": "193462", "NCBI_taxonomy_cvterm_id": "39503"}, "protein_sequence": {"accession": "AAF67494.2", "sequence": "MKSALSTWKPSDRPPDPTLPEPPAQLRRIFRLFRPYRGRLAVVGLLVGASSLVAVASPFMLREILDTAIPQGRTGLLSLLALGMILTAVLSSVFGVVQTLISTTVGQRVMHDLRTAVYAQLQRMPLAFFTRTRTGEVQSRIANDIGGMQATVTSTATSLVSNLTAVIATVVAMLALDWRLTVVSLLLLPVFVWISRRVGRERKRITLQRQKQMATMAATVTESLSVSGILLGRTMGRADSLTRSFAEESERLVDLEVRSNMAGRWRMSVIGIVMAAMPAVIYWAAGFVLQSGGTVVSIGTLVAFVSLQQGLFRPAVSLLATGVQMQTSLALFQRIFEYLDLPVDITEPERPVALDKVRGEVRFDGVDFSYEEKDGNTLHGLDLTVPAGGSLAVVGPTGSGKSTLSYLVPRLYDVTGGRVLLDGVDVRDLAFDTLARAVGVVSQETYLFHASVADNLRFAKPDATDEEIEKAARAAQIHEHIVTLPDGYDTLVGERGYRFSGGEKQRLAIARTILRDPPVLVLDEATSALDTRTEHAVQQAIDSLSEGRTTITIAHRLSTVRDADQIVVLDAGRIAERGTHEELIDRDGRYAALVRRDGAPAPAPVPARDERVGAA"}}}}}}, "$insert": {"CARD_short_name": "novA"}}, "633": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1460": {"$update": {"dna_sequence": {"$update": {"accession": "KF297584.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-355"}}, "1216": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1387": {"$update": {"dna_sequence": {"$update": {"accession": "KJ776406.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-119"}}, "635": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1532": {"$update": {"dna_sequence": {"$update": {"accession": "KF203106.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-332"}}, "636": {"$update": {"ARO_description": "CFE-1 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"902": {"$update": {"dna_sequence": {"$update": {"accession": "AB107899.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CFE-1"}}, "637": {"$update": {"ARO_description": "OXY-6-2 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"983": {"$update": {"dna_sequence": {"$update": {"accession": "AJ871875.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-6-2"}}, "638": {"$update": {"ARO_description": "ACT-16 is a beta-lactamase found in Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"1341": {"$update": {"dna_sequence": {"$update": {"accession": "AB737978.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-16"}}, "639": {"$update": {"ARO_description": "AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri."}, "$insert": {"CARD_short_name": "AAC(3)-IV"}}, "1218": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1649": {"$update": {"dna_sequence": {"$update": {"accession": "KM114268.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-219"}}, "1219": {"$update": {"ARO_description": "Also known as vanRN, is a vanR variant found in the vanN gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"379": {"$update": {"dna_sequence": {"$update": {"accession": "JF802084.1"}}}}}}}}, "model_name": "vanR gene in vanN cluster", "ARO_name": "vanR gene in vanN cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanN_cl"}}, "4378": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-17"}}, "1394": {"$update": {"ARO_description": "OXA-257 is a beta-lactamase found in A. bereziniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1760": {"$update": {"dna_sequence": {"$update": {"accession": "KC567681.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-257"}}, "5658": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-191"}}, "5659": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SIM-2"}}, "4372": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6747": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-11"}}, "780": {"$update": {"ARO_description": "CARB-9 is a beta-lactamase found in Vibrio cholerae.", "model_sequences": {"$update": {"sequence": {"$update": {"1973": {"$update": {"dna_sequence": {"$update": {"accession": "AY248038.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-9"}}, "4370": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6745": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-1"}}, "2416": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "abcA"}}, "5652": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-115"}}, "4377": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6752": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-16"}}, "4374": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-13"}}, "4375": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-14"}}, "465": {"$update": {"ARO_description": "Also known as vanSO, is a vanS variant found in the vanO gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"4550": {"$update": {"dna_sequence": {"$update": {"accession": "KF478993.1"}}}}}}}}, "model_name": "vanS gene in vanO cluster", "ARO_name": "vanS gene in vanO cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanO_cl"}}, "2899": {"$update": {"ARO_description": "A chloramphenicol resistance determinant described in a Vibrio anguillarum plasmid sequence.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Vang_ACT_CHL"}}, "1728": {"$update": {"ARO_description": "OXA-42 is a beta-lactamase found in Burkholderia pseudomallei.", "model_sequences": {"$update": {"sequence": {"$update": {"1934": {"$update": {"dna_sequence": {"$update": {"accession": "AJ488302.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-42"}}, "4636": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7011": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-23"}}, "2895": {"$update": {"ARO_description": "A chloramphenicol resistance determinant described in an Enterococcus faecium plasmid.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Efac_ACT_CHL"}}, "2894": {"$update": {"ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Ssui_ACT_CHL"}}, "2897": {"$update": {"ARO_description": "A chloramphenicol acetyltransferase and resistance determinant described in Enterococcus faecalis.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Efae_ACT_CHL"}}, "1729": {"$update": {"ARO_description": "CTX-M-66 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1107": {"$update": {"dna_sequence": {"$update": {"accession": "EF576988.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-66"}}, "2891": {"$update": {"ARO_description": "A chloramphenicol resistance determinant described in Alkalihalobacillus clausii.", "model_sequences": {"$update": {"sequence": {"$update": {"4424": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Alkalihalobacillus clausii"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}, "model_name": "Alkalihalobacillus clausii chloramphenicol acetyltransferase", "ARO_name": "Alkalihalobacillus clausii chloramphenicol acetyltransferase"}, "$insert": {"CARD_short_name": "Acla_ACT_CHL"}}, "2890": {"$update": {"ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Afab_ACT_CHL"}}, "2893": {"$update": {"ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Ccol_ACT_CHL"}}, "1106": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1025": {"$update": {"dna_sequence": {"$update": {"accession": "JN104597.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-5"}}, "1107": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1468": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666064.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PDC-2"}}, "1104": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "acrB"}}, "1105": {"$update": {"ARO_description": "AAC(3)-VIa is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae, S. enterica and E. coli.", "model_sequences": {"$update": {"sequence": {"$update": {"659": {"$update": {"dna_sequence": {"$update": {"accession": "M88012.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-VIa"}}, "1102": {"$update": {"ARO_description": "QnrB29 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"235": {"$update": {"dna_sequence": {"$update": {"accession": "HM439649.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB29"}}, "1103": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1895": {"$update": {"dna_sequence": {"$update": {"accession": "AY513266.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-17"}}, "1452": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1494": {"$update": {"dna_sequence": {"$update": {"accession": "KF944358.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-216"}}, "1453": {"$update": {"ARO_description": "Also known as vanYD, is a vanY variant found in the vanD gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"338": {"$update": {"dna_sequence": {"$update": {"accession": "AY082011.1"}}}}}}}}, "model_name": "vanY gene in vanD cluster", "ARO_name": "vanY gene in vanD cluster"}, "$insert": {"CARD_short_name": "vanY_in_vanD_cl"}}, "4457": {"$insert": {"CARD_short_name": "CfiA27"}}, "1458": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1491": {"$update": {"dna_sequence": {"$update": {"accession": "DQ909059.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-157"}}, "1459": {"$update": {"ARO_description": "CTX-M-78 is a beta-lactamase found in Kluyvera georgiana.", "model_sequences": {"$update": {"sequence": {"8196": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAGAAAAAGCGTAAGGCGGGCGATATTAATGACGACAGCCTGTGTTTCGCTGCTGTTGGCCAGTGTGCCGCTGTATGCCCAAGCGAACGATATTCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGGGGACGACTGGGTGTGGCGTTGATTAACACCGCCGATAACACGCAGACGCTCTACCGCGCCGACGAGCGTTTTGCTATGTGCAGCACCAGTAAAGTGATGGCGGCGGCGGCGGTGCTTAAGCAAAGTGAAACGCAAAAAGACTTACTGAGTCAGCGGGTTGAAATTAAGTCCTCAGACTTGATTAACTACAACCCAATCGCTGAAAAGCACGTCAATGGCACGATGACACTCGGGGAGCTGAGCGCGGCGGCGCTGCAGTACAGCGATAATACTGCCATGAATAAGCTGATTGCCCATCTCGGGGGGCCGGGTAAAGTGACGGCATTTGCTCGCGTGATTGGCGATGACACTTTCCGGCTCGATCGTACCGAGCCGACGCTCAACACCGCGATCCCCGGCGACCCGCGCGATACCACCACGCCGTTAGCGATGGCGCAGACTCTACGCAATCTCACATTGGGCAATGCCCTGGGTGACACTCAGCGTGCGCAGCTGGTGACGTGGCTGAAAGGCAACACCACCGGCGCTGCCAGCATTCAGGCAGGGCTACCCACATCGTGGGTTGTCGGGGATAAAACCGGCAGCGGCGATTATGGTACGACGAATGATATCGCGGTTATTTGGCCGGAAGGTCGCGCGCCGCTCGTTCTGGTGACTTACTTCACCCAGCCGGAGCCGAAGGCAGAGAGCCGTCGTGACGTGCTCGCTGCTGCCGCCAGAATAGTCACCGACGGTTATTAG", "fmax": "876", "accession": "AM982522.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Kluyvera georgiana", "NCBI_taxonomy_id": "73098", "NCBI_taxonomy_cvterm_id": "36929"}, "protein_sequence": {"accession": "CAQ42481.2", "sequence": "MMRKSVRRAILMTTACVSLLLASVPLYAQANDIQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKDLLSQRVEIKSSDLINYNPIAEKHVNGTMTLGELSAAALQYSDNTAMNKLIAHLGGPGKVTAFARVIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRNLTLGNALGDTQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLVLVTYFTQPEPKAESRRDVLAAAARIVTDGY"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-78"}}, "1108": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"37": {"$update": {"dna_sequence": {"$update": {"accession": "CP003583.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Efac_liaS_DAP"}}, "4830": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7205": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-491"}}, "4080": {"$update": {"ARO_description": "DfrA36 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally described by Wuthrich et al., 2019, and isolated from Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"6453": {"$update": {"dna_sequence": {"$update": {"accession": "NG_065842.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DfrA36"}}, "4081": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6454": {"$update": {"dna_sequence": {"$update": {"accession": "NG_071175.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DfrA38"}}, "3869": {"$insert": {"CARD_short_name": "PDC-240"}}, "1725": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"842": {"$update": {"dna_sequence": {"$update": {"accession": "AF495873.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-101"}}, "4085": {"$update": {"ARO_description": "Dfr22 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally detected by Grape et al., (2005) and isolated from Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8135": {"dna_sequence": {"partial": "0", "sequence": "ATGAACCCGGAATTGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGCCCCGATATTCCCTGGAAAATCCCGGGTGAGCAAAAGATCTTTCGCAGGCTCACCGAGGGCAAAGTGGTCGTTATGGGCCGCAAGACGTTTGAGTCCATAGGCAAGCCCTTACCAAACCGCCGCACAGTGGTGCTCTCGCGCCAAGCCAGTTATAGCGCTGCTGGTTGTGCAGTTGTTTCAACGCTGTCGCAGGCTATTGCCATCGCAGCCGAACACGGCAAAGAGCTCTACGTGGCCGGCGGAGCCGAGGTATATGCACTGGCACTACCTCGTGCCGACGGCGTCTTTCTATCTGAGGTACATCAAACCTTCGAGGGTGACGCCTTCTTCCCTGTGCTCGACGAAGCAGAATTCGAGGTTGTCTCAGCCGAAACCGTTCAAGCCACAATCACGTACACGCACTCCGTCTATGCACGTCGTAACGGCTAA", "fmax": "822", "accession": "AJ628423.2", "fmin": "324", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "CAF31623.1", "sequence": "MNPELVRIYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRRTVVLSRQASYSAAGCAVVSTLSQAIAIAAEHGKELYVAGGAEVYALALPRADGVFLSEVHQTFEGDAFFPVLDEAEFEVVSAETVQATITYTHSVYARRNG"}}}}}}, "$insert": {"CARD_short_name": "dfr22"}}, "3863": {"$insert": {"CARD_short_name": "PDC-59"}}, "1722": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1723": {"$update": {"dna_sequence": {"$update": {"accession": "FR848831.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-184"}}, "3861": {"$insert": {"CARD_short_name": "PDC-54"}}, "3860": {"$insert": {"CARD_short_name": "PDC-43"}}, "3867": {"$insert": {"CARD_short_name": "PDC-52"}}, "3866": {"$update": {"ARO_description": "PDC-56 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 4883."}, "$insert": {"CARD_short_name": "PDC-56"}}, "3865": {"$update": {"ARO_description": "PDC-67 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 5065."}, "$insert": {"CARD_short_name": "PDC-67"}}, "1723": {"$update": {"ARO_description": "IMP-44 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"872": {"$update": {"dna_sequence": {"$update": {"accession": "AB777501.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-44"}}, "1357": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1861": {"$update": {"dna_sequence": {"$update": {"accession": "JX313020.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-132"}}, "3837": {"$update": {"ARO_description": "Mutations in Mycobacterium tuberculosis ethA conferring resistance to prothionamide, an analogue to isoniazid.", "ARO_category": {"$update": {"43319": {"$update": {"category_aro_description": "Mutations in ethA conferring resistance to prothionamide, an analogue of isoniazid."}}}}}, "$insert": {"CARD_short_name": "Mtub_ethA_PTO"}}, "5243": {"$insert": {"CARD_short_name": "PDC-103"}}, "5242": {"$insert": {"CARD_short_name": "PDC-102"}}, "1577": {"$update": {"ARO_description": "AAC(6')-32 is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"310": {"$update": {"dna_sequence": {"$update": {"accession": "EF614235.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-32"}}, "4681": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-39"}}, "1897": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"518": {"$update": {"dna_sequence": {"$update": {"accession": "M11036.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(L)"}}, "5722": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-73"}}, "5723": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8098": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "YEM-1"}}, "5720": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-72"}}, "5630": {"$insert": {"CARD_short_name": "PME-1"}}, "5724": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8099": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ZOG-1"}}, "2805": {"$update": {"ARO_category": {"$update": {"41330": {"$update": {"category_aro_description": "Point mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics."}}}}}, "$insert": {"CARD_short_name": "Mgal_23S_PLM"}}, "4832": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-597"}}, "3915": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6276": {"$update": {"dna_sequence": {"$update": {"accession": "NG_052649.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-145"}}, "3914": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6275": {"$update": {"dna_sequence": {"$update": {"accession": "NG_048795.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-125"}}, "3913": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6274": {"$update": {"dna_sequence": {"$update": {"accession": "NG_048794.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-124"}}, "3912": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6273": {"$update": {"dna_sequence": {"$update": {"accession": "NG_051215.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-141"}}, "3911": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6272": {"$update": {"dna_sequence": {"$update": {"accession": "NG_051753.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-142"}}, "2137": {"$update": {"ARO_description": "Sequence variants of Escherichia coli elongation factor Tu that confer resistance to kirromycin."}, "$insert": {"CARD_short_name": "Ecol_EFTu_KIR"}}, "5631": {"$insert": {"CARD_short_name": "POM-1"}}, "2134": {"$update": {"ARO_description": "CMY-36 is a beta-lactamase found in Klebsiella pneumoniae."}, "$insert": {"CARD_short_name": "CMY-36"}}, "3919": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6280": {"$update": {"dna_sequence": {"$update": {"accession": "NG_055473.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-155"}}, "3918": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6279": {"$update": {"dna_sequence": {"$update": {"accession": "NG_068165.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-171"}}, "4692": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-61"}}, "4153": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-59"}}, "4151": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-67"}}, "4159": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-68"}}, "4338": {"$insert": {"CARD_short_name": "ADC-80"}}, "4699": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-74"}}, "460": {"$update": {"ARO_description": "CMY-29 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"8209": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGTTCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA", "fmax": "1143", "accession": "EF685371.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ABS12248.1", "sequence": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQFPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ"}}}}}}, "$insert": {"CARD_short_name": "CMY-29"}}, "4698": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-73"}}, "4929": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-603"}}, "4034": {"$update": {"ARO_description": "PDC-376 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-376"}}, "216": {"$update": {"ARO_description": "LEN-9 is a beta-lactamase found in Klebsiella pneumoniae.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-9"}}, "217": {"$update": {"ARO_description": "Also known as vanXA, is a vanX variant found in the vanA gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3281": {"$update": {"dna_sequence": {"$update": {"accession": "M97297.1"}}}}}}}}, "model_name": "vanX gene in vanA cluster", "ARO_name": "vanX gene in vanA cluster"}, "$insert": {"CARD_short_name": "vanX_in_vanA_cl"}}, "214": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1621": {"$update": {"dna_sequence": {"$update": {"accession": "HQ661362.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-121"}}, "215": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2050": {"$update": {"dna_sequence": {"$update": {"accession": "L20573.1"}}}}}}}}}, "$insert": {"CARD_short_name": "bcrC"}}, "212": {"$update": {"ARO_description": "Point mutation in Staphylococcus aureus parC resulting in fluoroquinolone resistance.", "model_name": "Staphylococcus aureus parC conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Saur_parC_FLO"}}, "213": {"$update": {"ARO_description": "OXA-21 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"8191": {"dna_sequence": {"partial": "0", "sequence": "ATGGCAATCCGAATCTTCGCAATACTTTTCTCCACTTTTGTTTTTGGCACGTTCGCGCATGCACAAGAAGGCATGCGCGAACGTTCTGACTGGCGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAACAGATCGTGTCATATTGGTTTTTGATCAGGTGCGGTCAGAGAAACGCTACTCGCCGGCCTCGACATTCAAGATTCCACATACACTTTTTGCACTTGACGCAGGCGCTGCACGTGATGAGTTTCAAGTTTTCCGATGGGACGGCATCAAAAGAAGCTTTGCAGCTCACAACCAAGACCAAGACTTGCGATCAGCAATGCGGAATTCTACTGTCTGGATTTATGAGCTATTTGCAAAAGAGATCGGTGAAGACAAGGCTCGACGCTATTTGAAGCAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGATGGCAATCTTGCTATCGCGGCACAAGAACAGATTGCATTTCTCAGGAAGCTCTATCATAACGAGTTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGACCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGCGCAAAGACGGGCTGGGAAGGCCGCATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCCCCGTATTTTTCGCACTGAATATTGATACGCCAAACAGGATGGATGACCTTTTCAAAAGGGAGGCAATAGTGCGGGCAATCCTTCGCTCTATCGAAGCGTTGCCGCCCAACCCGGCAGTCAACTCGGACGCAGCGCGATAA", "fmax": "828", "accession": "Y10693.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "CAA71699.2", "sequence": "MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILVFDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLRSAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQIAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-21"}}, "210": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1315": {"$update": {"dna_sequence": {"$update": {"accession": "AY070258.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-35"}}, "211": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2035": {"$update": {"dna_sequence": {"$update": {"accession": "KC783461.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-206"}}, "3331": {"$update": {"ARO_description": "A class ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii."}, "$insert": {"CARD_short_name": "ADC-62"}}, "1530": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1936": {"$update": {"dna_sequence": {"$update": {"accession": "DQ491200.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-67"}}, "4036": {"$update": {"ARO_description": "PDC-231 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-231"}}, "218": {"$update": {"model_sequences": {"$update": {"sequence": {"8165": {"dna_sequence": {"partial": "0", "sequence": "TTGTTAATACTCAAAGGAACAAAGACGGTTGATTTATCAAAAGATGAATTGACAGAAATAATAGGTCAGTTTGATCGTGTGCATATAGATTTGGGTACTGGAGACGGTAGAAATATATATAAACTTGCAATTAATGATCAAAACACTTTCTATATCGGAATAGATCCGGTAAAAGAAAACTTGTTTGATATATCCAAAAAAATTATAAAGAAGCCCTCAAAAGGAGGGCTATCTAATGTGGTGTTTGTTATTGCAGCTGCAGAGTCTCTCCCTTTTGAATTGAAAAACATTGCTGATTCAATTTCCATTTTGTTTCCTTGGGGGACATTGCTTGAATATGTAATTAAACCGAATAGAGATATTCTTTCGAATGTTGCAGATTTGGCTAAAAAAGAAGCTCACTTTGAATTTGTGACCACATACTCAGATTCATACGAAGAAGCGGAAATAAAAAAAAGAGGACTTCCTCTTTTAAGTAAGGCCTATTTTTTGAGCGAACAATACAAAGCTGAATTATCAAACTCAGGTTTTCGCATTGATGATGTTAAGGAATTGGACAATGAGTATGTAAAACAGTTTAATTCTCTTTGGGCAAAGCGATTAGCTTTTGGGCGAAAACGTTCTTTCTTTCGAGTTTCTGGCCATGTTTCAAAACATTAA", "fmax": "91823", "accession": "AB261016.2", "fmin": "91163", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "BAF80809.1", "sequence": "MLILKGTKTVDLSKDELTEIIGQFDRVHIDLGTGDGRNIYKLAINDQNTFYIGIDPVKENLFDISKKIIKKPSKGGLSNVVFVIAAAESLPFELKNIADSISILFPWGTLLEYVIKPNRDILSNVADLAKKEAHFEFVTTYSDSYEEAEIKKRGLPLLSKAYFLSEQYKAELSNSGFRIDDVKELDNEYVKQFNSLWAKRLAFGRKRSFFRVSGHVSKH"}}}}}}, "$insert": {"CARD_short_name": "npmA"}}, "219": {"$update": {"ARO_description": "OKP-A-12 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8273": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGCATTCGCCAGCCCTCAGCCGCTCGAGCAAGTTACACGCAGCGAAAGTCAGCTGGCGGGCCGCGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCACTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGAGACGAACAGCTGGATCGGCGGATCCGCTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGTGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTTGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAGCTCAATGAAGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCAGCCAGCATGGCCGCCACCCTGCGCAAGCTGCTAACCAGCCACGCGCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCAGGTGGCCGGCCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGCGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGAACGGCAAAGCGGAGCGCATCGTGGTGATCTATCTGCGGGATACGCCGGCGACCATGGCCGAACGTAACCAGCAGATCGCCAGAATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "879", "accession": "AM850916.2", "fmin": "18", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12354.2", "sequence": "MRYVRLCLISLIAALPLAAFASPQPLEQVTRSESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIRYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMAATLRKLLTSHALSARSQQQLLQWMVDDQVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPNGKAERIVVIYLRDTPATMAERNQQIARIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-12"}}, "4837": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-502"}}, "1021": {"$update": {"ARO_description": "CTX-M-54 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8155": {"dna_sequence": {"partial": "0", "sequence": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCAGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGACTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA", "fmax": "3050", "accession": "DQ303459.3", "fmin": "2174", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "ABC18328.3", "sequence": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEQTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-54"}}, "2139": {"$update": {"ARO_description": "Also known as vanSD, is a mutated vanS variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis.", "model_sequences": {"$update": {"sequence": {"$update": {"3440": {"$update": {"dna_sequence": {"$update": {"accession": "EU999036.1"}}, "protein_sequence": {"$update": {"accession": "ACM47284.1"}}}}}}}}, "model_name": "vanS gene in vanD cluster", "ARO_name": "vanS gene in vanD cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanD_cl"}}, "1112": {"$update": {"ARO_description": "OXA-58 is a beta-lactamase found in A. baumannii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-58"}}, "4393": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6768": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-31"}}, "3285": {"$insert": {"CARD_short_name": "tet(49)"}}, "462": {"$update": {"ARO_description": "Point mutations that occur within Staphylococcus aureus pgsA gene resulting in resistance to daptomycin."}, "$insert": {"CARD_short_name": "Saur_pgsA_DAP"}}, "939": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1901": {"$update": {"dna_sequence": {"$update": {"accession": "JF274247.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-113"}}, "4": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1393": {"$update": {"dna_sequence": {"$update": {"accession": "HQ845196.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-52"}}, "3489": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-404"}}, "3488": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-403"}}, "3481": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-364"}}, "3480": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-346"}}, "3483": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-373"}}, "3482": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-372"}}, "3485": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-392"}}, "3484": {"$insert": {"CARD_short_name": "tva(A)"}}, "3487": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-401"}}, "3486": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-400"}}, "4563": {"$insert": {"CARD_short_name": "CTX-M-234"}}, "4562": {"$insert": {"CARD_short_name": "CTX-M-233"}}, "4561": {"$insert": {"CARD_short_name": "CTX-M-232"}}, "4560": {"$insert": {"CARD_short_name": "CTX-M-231"}}, "4567": {"$insert": {"CARD_short_name": "CTX-M-238"}}, "4566": {"$insert": {"CARD_short_name": "CTX-M-237"}}, "3649": {"$update": {"ARO_description": "MtrR is a repressor of mtrCDE efflux pump expression, point mutations in mtrR confer resistance to azithromycin and other drugs.", "model_sequences": {"$update": {"sequence": {"8361": {"dna_sequence": {"partial": "0", "sequence": "ATGAGAAAAACCAAAACCGAAGCCTTGAAAACCAAAGAACACCTGATGCTTGCCGCCTTGGAAACCTTTTACCGCAAAGGGATTGCCCGCACCTCGCTCAACGAAATCGCCCAAGCCGCCGGCGTAACGCGCGGCGCGCTCTATTGGCATTTCAAAAATAAGGAAGACTTGTTTGACGCGTTGTTCCAACGTATCTGCGACGACATCGAAAACTGCATCGCGCAAGATGCCGCAGATGCCGAAGGAGGTTCTTGGACGGTATTCCGCCACACGCTGCTGCACTTTTTCGAGCGGCTGCAAAGCAACGACATCTACTACAAATTCCACAACATCCTGTTTTTAAAATGCGAACACACGGAGCAAAACGCCGCCGTTATCGCCATTGCCCGCAAGCATCAGGCAATCTGGCGCGAGAAAATTACCGCCGTTTTGACCGAAGCGGTGGAAAATCAGGATTTGGCTGACGATTTGGACAAGGAAACGGCGGTCATCTTCATCAAATCGACGTTGGACGGGCTGATTTGGCGTTGGTTCTCTTCCGGCGAAAGTTTCGATTTGGGCAAAACCGCCCCGCGCATCATCGGGATAATGATGGACAACTTGGAAAACCATCCCTGCCTGCGCCGGAAATAA", "fmax": "1333499", "accession": "CP001050.1", "fmin": "1332866", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae NCCP11945", "NCBI_taxonomy_id": "521006", "NCBI_taxonomy_cvterm_id": "37080"}, "protein_sequence": {"accession": "ACF30254.1", "sequence": "MRKTKTEALKTKEHLMLAALETFYRKGIARTSLNEIAQAAGVTRGALYWHFKNKEDLFDALFQRICDDIENCIAQDAADAEGGSWTVFRHTLLHFFERLQSNDIYYKFHNILFLKCEHTEQNAAVIAIARKHQAIWREKITAVLTEAVENQDLADDLDKETAVIFIKSTLDGLIWRWFSSGESFDLGKTAPRIIGIMMDNLENHPCLRRK"}}}}}, "model_name": "Neisseria gonorrhoeae mtrR with mutation conferring resistance"}, "$insert": {"CARD_short_name": "Ngon_mtrR_AZM"}}, "4564": {"$insert": {"CARD_short_name": "CTX-M-235"}}, "3646": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic.", "model_sequences": {"$update": {"sequence": {"$update": {"5918": {"$update": {"dna_sequence": {"$update": {"accession": "NR_103957.1"}}}}}}}}, "model_name": "Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin"}, "$insert": {"CARD_short_name": "Ngon_23S_AZM"}}, "3645": {"$update": {"ARO_description": "A class-A broad-spectrum beta-lactamase from Klebsiella.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-58"}}, "3644": {"$update": {"ARO_description": "A class-A broad-spectrum beta-lactamase from Klebsiella.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-55"}}, "3643": {"$update": {"ARO_description": "A class-A broad-spectrum beta-lactamase from Klebsiella.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-51"}}, "3642": {"$update": {"ARO_description": "A class-A broad-spectrum beta-lactamase from Klebsiella.", "model_sequences": {"$update": {"sequence": {"$update": {"5913": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Klebsiella variicola subsp. tropica"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-43"}}, "3641": {"$update": {"ARO_description": "A class-A broad-spectrum beta-lactamase from Klebsiella.", "model_sequences": {"$update": {"sequence": {"$update": {"5912": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Klebsiella variicola subsp. tropica"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-42"}}, "3640": {"$update": {"ARO_description": "A class-A broad-spectrum beta-lactamase identified from Klebsiella.", "model_sequences": {"$update": {"sequence": {"$update": {"5911": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Klebsiella variicola subsp. tropica"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-41"}}, "2550": {"$insert": {"CARD_short_name": "Cdif_gyrA_FLO"}}, "2551": {"$update": {"ARO_description": "This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX."}, "$insert": {"CARD_short_name": "vanI_cluster"}}, "2012": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1473": {"$update": {"dna_sequence": {"$update": {"accession": "KF705209.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-178"}}, "61": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1377": {"$update": {"dna_sequence": {"$update": {"accession": "KF203104.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-330"}}, "2396": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-368"}}, "2397": {"$update": {"ARO_description": "A gene that produces the protein lipid A 4'-phosphatase."}, "$insert": {"CARD_short_name": "pgpB"}}, "2394": {"$insert": {"CARD_short_name": "Saur_menA_LYS"}}, "2395": {"$insert": {"CARD_short_name": "apmA"}}, "2398": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-220"}}, "65": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1338": {"$update": {"dna_sequence": {"$update": {"accession": "JQ772478.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-21"}}, "2778": {"$update": {"model_name": "MCR-2.1"}, "$insert": {"CARD_short_name": "MCR-2.1"}}, "2779": {"$update": {"ARO_description": "FosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule."}, "$insert": {"CARD_short_name": "FosA6"}}, "4899": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-572"}}, "4898": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-569"}}, "5014": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-702"}}, "5015": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-703"}}, "5016": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-704"}}, "5017": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-705"}}, "2770": {"$insert": {"CARD_short_name": "kamB"}}, "2771": {"$update": {"ARO_description": "QepA2 is a plasmid-mediated quinolone resistance pump found in an Escherichia coli isolate from France.", "model_sequences": {"$update": {"sequence": {"8346": {"dna_sequence": {"partial": "0", "sequence": "ATGTCCGCCACGCTCCACGACACCGCAGCGGATCGTCGGAAGGCCACCCGCCGCGAATGGATCGGCCTGGCCGTGGTCGCCCTGCCGTGCCTGGTCTACGCCATGGACCTCACGGTGCTGAACCTGGCGCTGCCGGTGCTCAGCCGTGAACTGCAGCCCTCCAGCGCCCAGCTTCTCTGGATCCTGGACATCTACGGCTTCTTCGTCGCCGGCTTCCTGATCACCATGGGCACGCTGGGCGACCGCATCGGCCGGCGCCGGCTGTTGTTGATCGGCGCGGCGTTCTTCGCATTCGGCTCGGTGCTCGCGGCGCTGGCCGATACCGCCGCGCTGTTGATCGCGGCGCGCGCCTTGCTCGGCCTGGCCGGCGCCACCATCGCGCCGTCCACCATGGCGCTGATCCGCAACATGTTCCACGACCCGCGCCAGCGCCAGTTCGCCATCGGCGTGTGGATCGCCGCGTTTTCGCTGGGCAGCGCGATCGGTCCGCTGGTCGGCGGCGTGTTGCTGGAGTTCTTCCACTGGGGCGCCGTGTTCTGGCTCAACGTGCCGGTGATGCTGCTGACGCTGGCGCTCGGCCCTCGCTTCCTGCCCGAGTATCGTGATCCGGACGCGGGGCACCTGGACCTGGCCAGCGTGCTGCTGTCGCTGGCGGCGGTGCTGCTGACGATCTACGGGCTCAAGCAGTTGGCCGAGCATGGAGCGGGCCTCGCCTCGATGGCTGCGCTGCTGGCCGGGCTGGCGGTCGGGGCGCTGTTCCTGCGCCGCCAGGGCCACATCGCCTACCCGCTGCTGGACCTGCGGCTGTTCGCGCACGCGCCGTTCCGCGCGGCGCTGGCGGCGTATGCGCTGGCCGCGCTGGCCATGTTCGGCGTCTACATCTTCATGACGCAGTACCTGCAGCTCGTGCTGGGGCTGTCGCCGCTGCAGGCCGGGCTGGCCACGCTGCCCTGGTCCCTGTGCTTCGTCATCGGTTCGCTGTTGTCGCCGCAGCTCGCGGCGCGCTGGCCGGCGGCGCGCATCCTCGTCGTGGGCCTGTCGGCAGCGGCGTTCGGCTTCGCCGTGCTGGGGCTGGGGCAGGGCCTGTGGTGGCTGGTGCCGGCCACGATCGTCATGGGCCTGGGCCTGGCGCCGGTGTTCACCATCGGCAACGAGATCATCATCACCAGCGCGCCGTCCGAGCGCGCGGGCGCGGCCTCGGCCTTGTCGGAGACGGTGTCCGAATTCAGCGGCGCGCTGGGCATCGCGCTGTTCGGCAGCGTCGGCCTGGTGGTCTACCGGCAGGCGCTGACCAGCGCGGCGCTGCCCGGCCTGCCGGCCGATGCGCTGCAGGCGGCCGGTGCCTCGCTCGGGGGCGCCGTGCACCTGGCCGACACCCTGCCGGCGTGGCAGGGCGCGGCCTTGCTGGCGGCCGCACGCGCGGGCTTCACCGATGCGCTGCAGGCCACGGCCTGGGCCGGCGCGGTGCTGGTGCTGGTGGCCGCTGGGCTGGTGGCGCGCCTGCTGCGCAAGCGCCCAGCGCTCGCATCTGGTTGA", "fmax": "3207", "accession": "EU847537.1", "fmin": "1671", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ACF70723.1", "sequence": "MSATLHDTAADRRKATRREWIGLAVVALPCLVYAMDLTVLNLALPVLSRELQPSSAQLLWILDIYGFFVAGFLITMGTLGDRIGRRRLLLIGAAFFAFGSVLAALADTAALLIAARALLGLAGATIAPSTMALIRNMFHDPRQRQFAIGVWIAAFSLGSAIGPLVGGVLLEFFHWGAVFWLNVPVMLLTLALGPRFLPEYRDPDAGHLDLASVLLSLAAVLLTIYGLKQLAEHGAGLASMAALLAGLAVGALFLRRQGHIAYPLLDLRLFAHAPFRAALAAYALAALAMFGVYIFMTQYLQLVLGLSPLQAGLATLPWSLCFVIGSLLSPQLAARWPAARILVVGLSAAAFGFAVLGLGQGLWWLVPATIVMGLGLAPVFTIGNEIIITSAPSERAGAASALSETVSEFSGALGIALFGSVGLVVYRQALTSAALPGLPADALQAAGASLGGAVHLADTLPAWQGAALLAAARAGFTDALQATAWAGAVLVLVAAGLVARLLRKRPALASG"}}}}}}, "$insert": {"CARD_short_name": "QepA2"}}, "4891": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-562"}}, "4890": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-561"}}, "2774": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4086": {"$update": {"dna_sequence": {"$update": {"accession": "AB758278.1"}}}}}}}}}, "$insert": {"CARD_short_name": "TMB-2"}}, "2775": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "Paer_soxR"}}, "4895": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-566"}}, "4894": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-565"}}, "1401": {"$insert": {"CARD_short_name": "mefE"}}, "4710": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-85"}}, "5165": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-868"}}, "1858": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1135": {"$update": {"dna_sequence": {"$update": {"accession": "KJ173478.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-387"}}, "1859": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3307": {"$update": {"dna_sequence": {"$update": {"accession": "KM555152.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrVC7"}}, "1850": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"653": {"$update": {"dna_sequence": {"$update": {"accession": "AB016934.1"}}}}}}}}}, "$insert": {"CARD_short_name": "FomB"}}, "4419": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-33"}}, "4418": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-32"}}, "4417": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-31"}}, "4416": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-30"}}, "1852": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"691": {"$update": {"dna_sequence": {"$update": {"accession": "JQ808129.1"}}}}}}}}}, "$insert": {"CARD_short_name": "rmtF"}}, "1853": {"$update": {"ARO_description": "OXA-20 is a beta-lactamase found in P. aeruginosa.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-20"}}, "1854": {"$update": {"model_sequences": {"$update": {"sequence": {"8181": {"dna_sequence": {"partial": "0", "sequence": "ATGAGCTTTGACGATGCCCTAGCGTCCATCCTTTCCTCAAAAAAATATCGTTCCCTCTGCCCGGATACCGTACGGCGGATTTTAGATCAGGAATGGGGGCGGCACAAATCGCCTAAGCTGGCAGTGGAGGCCACTCGCACCCGGCTGCACGGGATTTGCGGGGCCTATGTCACGCCGGAATCGCTCAAGGCTGCAGCAGCGGCATTATCGGTTGGCGATGTGCAAAAGGCACTGTCGCTGCACGCCTCTACCAAGGAGCGGTTGGCCGAATTGGACTGCCTCTACGATTTTATCTTTTCTGGCGGGGTGCCCCATCGTGTGTTGGATATCGCTTGCGGCCTAAACCCGCTGGCCCTCTTTATACGTGACATAACATCTGTATGGGCGTGCGACATCCATCAGGGGTTGGGCGATGTGATCACCCCCTTTGCCCATCATCAGGGATTGGACTTCACGTTCGCCCTGCAGGATGTGATGTGTACGCCGCCCACTGAGACGGGGGATTTGGCACTGGTATTTAAATTACTGCCTTTGCTGGAGCGAGAGCAAGCTGGCGCCGCCATGGCGCTACTGCAGGCACTAGCTACCCCTCGGATTGCCGTCAGCTTCCCCACCCGCAGTTTAGGCGGGCGCGGCAAGGGCATGGAAGCAAACTATTCCGCATGGTTCGAGGGGGCACTGCCTGATGAATTTGAAATTGAGGATACCAAGACCATTGGAATAGAGCTTGTGTACATGATAAAAAGGAATAAGTGA", "fmax": "6237", "accession": "AB083212.2", "fmin": "5481", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "BAC20579.1", "sequence": "MSFDDALASILSSKKYRSLCPDTVRRILDQEWGRHKSPKLAVEATRTRLHGICGAYVTPESLKAAAAALSVGDVQKALSLHASTKERLAELDCLYDFIFSGGVPHRVLDIACGLNPLALFIRDITSVWACDIHQGLGDVITPFAHHQGLDFTFALQDVMCTPPTETGDLALVFKLLPLLEREQAGAAMALLQALATPRIAVSFPTRSLGGRGKGMEANYSAWFEGALPDEFEIEDTKTIGIELVYMIKRNK"}}}}}}, "$insert": {"CARD_short_name": "rmtA"}}, "4412": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-26"}}, "1856": {"$update": {"ARO_description": "QnrB20 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"573": {"$update": {"dna_sequence": {"$update": {"accession": "AB379831.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB20"}}, "1857": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1166": {"$update": {"dna_sequence": {"$update": {"accession": "AY524988.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-9"}}, "5691": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-40"}}, "919": {"$update": {"ARO_description": "PER-1 is a beta-lactamase found in Pseudomonas aeruginosa.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-1"}}, "918": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1726": {"$update": {"dna_sequence": {"$update": {"accession": "Y10281.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-49"}}, "4969": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-644"}}, "4968": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-643"}}, "915": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2019": {"$update": {"dna_sequence": {"$update": {"accession": "AM941847.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-106"}}, "914": {"$update": {"ARO_description": "ANT(6)-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Staphylococcus epidermidis, E. faecium, Streptococcus suis, S. aureus, E. faecalis and Streptococcus mitis.", "ARO_category": {"$update": {"36364": {"$update": {"category_aro_description": "Nucelotidylylation of streptomycin at the hydroxyl group at position 6."}}}}}, "$insert": {"CARD_short_name": "ANT(6)-Ia"}}, "917": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"832": {"$update": {"dna_sequence": {"$update": {"accession": "KM233165.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-186"}}, "4964": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-638"}}, "911": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"822": {"$update": {"dna_sequence": {"$update": {"accession": "FN645444.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-50"}}, "910": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7": {"$update": {"dna_sequence": {"$update": {"accession": "KJ151292.1"}}}}}}}}}, "$insert": {"CARD_short_name": "rphA"}}, "913": {"$update": {"ARO_description": "OXY-6-4 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1141": {"$update": {"dna_sequence": {"$update": {"accession": "AJ871877.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-6-4"}}, "912": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-13"}}, "5432": {"$insert": {"CARD_short_name": "PDC-301"}}, "5450": {"$insert": {"CARD_short_name": "PDC-32"}}, "5694": {"$update": {"ARO_description": "From Lahey's list of beta-lactamases, no additional information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-45"}}, "4479": {"$insert": {"CARD_short_name": "CMY-8b"}}, "5433": {"$insert": {"CARD_short_name": "PDC-302"}}, "4270": {"$insert": {"CARD_short_name": "ADC-205"}}, "5695": {"$update": {"ARO_description": "From Lahey's list of beta-lactamases, no additional information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-46"}}, "5430": {"$insert": {"CARD_short_name": "PDC-30"}}, "1933": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1944": {"$update": {"dna_sequence": {"$update": {"accession": "JX121127.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-160"}}, "1932": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1339": {"$update": {"dna_sequence": {"$update": {"accession": "JQ002629.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-32"}}, "1931": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"926": {"$update": {"dna_sequence": {"$update": {"accession": "AM183304.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-150"}}, "1589": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"984": {"$update": {"dna_sequence": {"$update": {"accession": "AY740681.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-3"}}, "5128": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-826"}}, "5287": {"$insert": {"CARD_short_name": "PDC-15"}}, "1935": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2055": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Mtub_gyrA_FLO"}}, "1934": {"$update": {"ARO_description": "lnuD is a plasmid-mediated nucleotidyltransferase found in Streptococcus uberis.", "model_sequences": {"$update": {"sequence": {"$update": {"153": {"$update": {"dna_sequence": {"$update": {"accession": "EF452177.1"}}}}}}}}}, "$insert": {"CARD_short_name": "lnuD"}}, "3269": {"$update": {"ARO_description": "Point mutations in the rpoB region of Clostridioides difficile which confer resistance to rifampin and rifampicin antibiotics."}, "$insert": {"CARD_short_name": "Cdif_rpoB_RIF"}}, "3368": {"$update": {"ARO_description": "A rRNA methyltransferase conferring high-level evernimicin resistance.", "model_sequences": {"$update": {"sequence": {"8348": {"dna_sequence": {"partial": "0", "sequence": "ATGACTCTTTATTTTGCGAGCGTATTGTCTGGATTAGAATACGTTTTATCAAATGAAATTAACAACAAGGTGAGTGATTCTGAAATAATTCAAATAAATAGAGGGAAGGTTTTCTTTACCACAGCTGAGTCTTTTACATGCTTAAGTTCTTTAAGGTCAGCAGATCACTTGTTTCAAGTTATTGATCAATTTCAAATCGGTCCACATAAAAAGCACTTATCTCAGGTAAGCGAGCGAATATCCCAGTTGGATTTAGAATTTATTGATCATAAAGATTTATTTTGGGTAAATGCAAGCCGTAAAGGAAAACAAACCTATAGTCGCTTTGAATTAGCAAAAAAAGCAATGGAGGGTATTAATAAGCGTTACCCTGATTGGAACATTGGAACGTCTCAAAATCATCAGATAGAATTCAGACTCGACATTGAACATCATAATGTGATTTTTTCACTTCGGCTTACAGATGCGACGTTTCGTTTTCGAAATCAGACACGACGGTTCTCTCGTGCATCATTACTTCCTTCTGTGGCTCATGCGATGGTGTGGTTGTCAGATCCTGAATCGAAAGATGTTTTCGTAGACTTTTGTTGTGGTTCAGGCACAATTTTGTCTGAACGAGCCACATACCCTGCAAATCAGATAATTGGTGGAGATATATCTGAAGCAGTCACAAAGATAGCCAAAAGTAATCTCGATGATTCGAAGGTGCAAGTTAATGTTTGGGATGCACGGAAATTGCCTTTTTCTACTGGCTGTGTCGATAAAATTGTTACTAATCTTCCATTTGGAAGACAAATTTCCCCTGACGAGGACTTAGAATTGTTCAATCACCATATTATGATTGAAGTATGTAGAGTCTTGAAGCCAAATGGGAGAGCCGTTATTTTGTCTGAGAGTGTCAATCAATTGTTTTGGGAAGCAAAACGATTAGGCCTTTTTTGTCTGGAATCTTATCCTTTGAGTTTGAAGGGCGTGAATCCTACCTTGTTTGTGTTTGAAAAACAAGATGGACTTAGAAGGAAGTAG", "fmax": "1685", "accession": "AF403298.1", "fmin": "659", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"accession": "AAL02176.1", "sequence": "MTLYFASVLSGLEYVLSNEINNKVSDSEIIQINRGKVFFTTAESFTCLSSLRSADHLFQVIDQFQIGPHKKHLSQVSERISQLDLEFIDHKDLFWVNASRKGKQTYSRFELAKKAMEGINKRYPDWNIGTSQNHQIEFRLDIEHHNVIFSLRLTDATFRFRNQTRRFSRASLLPSVAHAMVWLSDPESKDVFVDFCCGSGTILSERATYPANQIIGGDISEAVTKIAKSNLDDSKVQVNVWDARKLPFSTGCVDKIVTNLPFGRQISPDEDLELFNHHIMIEVCRVLKPNGRAVILSESVNQLFWEAKRLGLFCLESYPLSLKGVNPTLFVFEKQDGLRRK"}}}}}, "ARO_category": {"$update": {"37697": {"$update": {"category_aro_description": "Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides."}}}}}, "$insert": {"CARD_short_name": "emtA"}}, "1939": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"170": {"$update": {"dna_sequence": {"$update": {"accession": "AF031332.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ix"}}, "1938": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mtrD"}}, "5120": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-816"}}, "5121": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-817"}}, "5122": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-819"}}, "5123": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-820"}}, "847": {"$update": {"model_sequences": {"$update": {"sequence": {"8377": {"dna_sequence": {"partial": "1", "sequence": "GTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGCTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCAA", "fmax": "864", "accession": "JF274245.1", "fmin": "1", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella sp. SH223", "NCBI_taxonomy_id": "1074434", "NCBI_taxonomy_cvterm_id": "39657"}, "protein_sequence": {"accession": "AEM44651.1", "sequence": "VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRAEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-108"}}, "846": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1983": {"$update": {"dna_sequence": {"$update": {"accession": "HG798963.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-12"}}, "845": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1955": {"$update": {"dna_sequence": {"$update": {"accession": "EU815939.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-163"}}, "844": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1178": {"$update": {"dna_sequence": {"$update": {"accession": "KM087844.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-117"}}, "843": {"$update": {"ARO_description": "QnrB14 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"255": {"$update": {"dna_sequence": {"$update": {"accession": "EU273757.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB14"}}, "842": {"$update": {"ARO_description": "PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin.", "model_sequences": {"$update": {"sequence": {"$update": {"4591": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ugd"}}, "3461": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-299"}}, "3460": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-298"}}, "4277": {"$insert": {"CARD_short_name": "ADC-212"}}, "5435": {"$insert": {"CARD_short_name": "PDC-304"}}, "849": {"$update": {"ARO_description": "OXA-138 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"8254": {"dna_sequence": {"partial": "0", "sequence": "ATGAACATTAAAACCCTCTTACTTATAACAAGCGCTATTTTTATTTCAGCCTGCTCACCTTATATAGTGACTGCTAATCCAAATCACAGCGCTTCAAAATCTGATGTAAAAGCAGAGAAAATTAAAAATTTATTTAACGAAGCACACACTACGGGTGTTTTAGTTATCCAACAAGGCCAAACTCAACAAAGCTATGGTAATGATCTTGCTCGTGCTTCGACCGAGTATGTACCTGCTTCGACCTTCAAAATGCTTAATGCTTTGATCGGCCTTGAGCACCATAAGGCAACCACCACAGAAGTATTTAAGTGGGATGGTAAAAAAAGGTTATTCCCAGAATGGGAAAAGGACATGACCCTAGGCGATGCCATGAAAGCTTCCGCTATTCCAGTTTATCAAGATTTAGCTCGTCGTATTGGACTTGAGCTCATGTCTAAGGAAGTGAAGCGTGTTGGTTATGGCAATGCAGATATCGGTACCCAAGTCGATAATTTTTGGGTGGTGGGTCCTTTAAAAATTACTCCTCAGCAAGAGGCACAGTTTGCTTACAAGCTAGCTAATAAAACGCTTCCATTTAGCCAAAAAGTCCAAGATGAAGTGCAATCCATGCTATTCATAGAAGAAAAGAATGGAAACAAAATATACGCAAAAAGTGGTTGGGGATGGGATGTAAACCCACAAGTAGGCTGGTTAACTGGATGGGTTGTTCAGCCTCAAGGGAATATTGTAGCGTTCTCCCTTAACTTAGAAATGAAAAAAGGAATACCTAGCTCTGTTCGAAAAGAGATTACTTATAAAAGCTTAGAACAATTAGGTATTTTATAG", "fmax": "2419", "accession": "EU670845.2", "fmin": "1594", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter nosocomialis", "NCBI_taxonomy_id": "106654", "NCBI_taxonomy_cvterm_id": "36949"}, "protein_sequence": {"accession": "ACD45467.1", "sequence": "MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-138"}}, "848": {"$update": {"ARO_description": "OKP-A-2 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8192": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTTTCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTCGAGCAAGTTACACGCAGCGAAAGTCAGCTGGCGGGCCGCGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGAGACGAACAGCTGGATCGGCGGATCCGCTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTTGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAGCTCAATGAAGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCAGCCAGCATGGCCGCCACCCTGCGCAAGCTGCTAACCAGCCACACTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCAGGTAGCCGGTCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGCGAGCGGGGCTCACGTGGCATTGTCGCCCTGCTCGGCCCGAACGGCAAAGCGGAGCGCATCGTGGTGATCTATCTGCGGGATACGCCGGCGACCATGGCCGAGCGTAACCAGCAGATCGCCAGAATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAG", "fmax": "861", "accession": "AJ635404.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAG25815.2", "sequence": "MRYVRLCLFSLIAALPLAVFASPQPLEQVTRSESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIRYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMAATLRKLLTSHTLSARSQQQLLQWMVDDQVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPNGKAERIVVIYLRDTPATMAERNQQIARIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-2"}}, "3364": {"$insert": {"CARD_short_name": "FusF"}}, "5278": {"$insert": {"CARD_short_name": "PDC-141"}}, "1583": {"$update": {"ARO_description": "QnrVC6 is an integron-mediated quinolone resistance protein found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"631": {"$update": {"dna_sequence": {"$update": {"accession": "KC202804.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrVC6"}}, "4927": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-601"}}, "5452": {"$insert": {"CARD_short_name": "PDC-321"}}, "5439": {"$insert": {"CARD_short_name": "PDC-309"}}, "932": {"$update": {"ARO_description": "GES-8 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"790": {"$update": {"dna_sequence": {"$update": {"accession": "AF329699.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-8"}}, "5308": {"$insert": {"CARD_short_name": "PDC-169"}}, "1587": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"878": {"$update": {"dna_sequence": {"$update": {"accession": "AF205943.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-10"}}, "2407": {"$insert": {"CARD_short_name": "Cgin_gyrA_FLO"}}, "1585": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1423": {"$update": {"dna_sequence": {"$update": {"accession": "GQ351345.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-73"}}, "5453": {"$insert": {"CARD_short_name": "PDC-322"}}, "1739": {"$update": {"model_sequences": {"$update": {"sequence": {"8247": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCACTCATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTACTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "993", "accession": "AF072684.2", "fmin": "117", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAC98092.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKITHRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-16"}}, "1738": {"$update": {"ARO_description": "CTX-M-45 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1981": {"$update": {"dna_sequence": {"$update": {"accession": "D89862.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-45"}}, "5309": {"$insert": {"CARD_short_name": "PDC-17"}}, "1731": {"$insert": {"CARD_short_name": "mphB"}}, "1730": {"$update": {"ARO_description": "OXA-235 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"8262": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAACTCTTATTTTGTTGCCTTTACTTAGTTGCTTGAGCCTGACAGCCTGTAGCTTGCCTGTTTCAAATTCGTCCTCTCAAATCACTTCAACTCAATCTATTCAAACCATTGCCAAATTATTTGATCAGGCACAAAGCTCTGGCGTTTTAGTAATTCAACGGGGCCCACATCTACAGGTCTATGGCAATGATTTGAGTCGTGCACATACCGAATATATTCCTGCTTCAACCTTTAAAATACTCAATGCCCTGATTGGCCTGCAACATGGTAAAGCCACGACCAATGAAATCTTTAAATGGGATGGCAAGAAGCGCAGTTTTGCAGCCTGGGAAAAAGACATGACTCTCGGCCAAGCCATGCAAGCTTCTGCTGTACCCGTCTATCAGGAACTGGCACGTCGCATTGGTCTGGAACTAATGCAACAGGAAGTGCAACGCATTCGATTTGGTAATCAGCAGATTGGTCAGCATATCGACAACTTCTGGTTAGTCGGACCTTTGAAAATCACCCCGGAACAAGAAGTCGAATTTGCCTCTGCGCTTGCTCAAGAGCAACTTGCCTTTGATCCTCAAGTCCAGCAACAAGTCAAAGCCATGTTACTGTTACAGGAGCGACAAGATTATCGACTATATGCCAAATCTGGTTGGGGTATGGATGTGGAGCCGCAAGTCGGCTGGCTCACCGGCTGGATCGAAACACCTCAGGACGAAATCGTGGCATTTTCACTGAATATGCAGATGCAAAGTAATATGGATCCGGCGATCCGTCTTAAAATTTTGCAGCAGGCCTTGGCCGAATTAGCGCTTTATCCGAAAGCTGAAGGGTAA", "fmax": "1421", "accession": "JQ820240.2", "fmin": "590", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "AFH36330.1", "sequence": "MKTLILLPLLSCLSLTACSLPVSNSSSQITSTQSIQTIAKLFDQAQSSGVLVIQRGPHLQVYGNDLSRAHTEYIPASTFKILNALIGLQHGKATTNEIFKWDGKKRSFAAWEKDMTLGQAMQASAVPVYQELARRIGLELMQQEVQRIRFGNQQIGQHIDNFWLVGPLKITPEQEVEFASALAQEQLAFDPQVQQQVKAMLLLQERQDYRLYAKSGWGMDVEPQVGWLTGWIETPQDEIVAFSLNMQMQSNMDPAIRLKILQQALAELALYPKAEG"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-235"}}, "1733": {"$update": {"ARO_description": "OXA-415 is a beta-lactamase. From the Lahey list of OXA beta-lactamases.", "model_sequences": {"$update": {"sequence": {"$update": {"1765": {"$update": {"dna_sequence": {"$update": {"accession": "KJ865754.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-415"}}, "1732": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1145": {"$update": {"dna_sequence": {"$update": {"accession": "JX121118.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-151"}}, "5234": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-11"}}, "5235": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-12"}}, "1737": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"185": {"$update": {"dna_sequence": {"$update": {"accession": "EF540343.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Alkalihalobacillus clausii"}}}}}}}}, "ARO_category": {"$update": {"36368": {"$update": {"category_aro_description": "Nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 4'."}}}}}, "$insert": {"CARD_short_name": "ANT(4')-Ia"}}, "1736": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1555": {"$update": {"dna_sequence": {"$update": {"accession": "AB901141.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-24"}}, "499": {"$update": {"ARO_description": "Also known as vanSB, is a vanS variant found in the vanB gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3454": {"$update": {"dna_sequence": {"$update": {"accession": "U35369.1"}}}}}}}}, "model_name": "vanS gene in vanB cluster", "ARO_name": "vanS gene in vanB cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanB_cl"}}, "1039": {"$update": {"ARO_description": "dfrB3 is an integron-encoded dihydrofolate reductase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"392": {"$update": {"dna_sequence": {"$update": {"accession": "GQ150744.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrB3"}}, "5454": {"$insert": {"CARD_short_name": "PDC-325"}}, "753": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1239": {"$update": {"dna_sequence": {"$update": {"accession": "AB636283.1"}}}}}}}}, "model_name": "SMB-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SMB-1"}}, "3782": {"$insert": {"CARD_short_name": "PDC-55"}}, "751": {"$update": {"ARO_description": "From the Lahey list of beta-lactamases. Not yet released. Isolated from Enterobacter cloacae.", "model_sequences": {"$update": {"sequence": {"$update": {"1572": {"$update": {"dna_sequence": {"$update": {"accession": "HG934763.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-217"}}, "750": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1313": {"$update": {"dna_sequence": {"$update": {"accession": "KF513177.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-172"}}, "757": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"762": {"$update": {"dna_sequence": {"$update": {"accession": "JQ733577.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-80"}}, "756": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"40": {"$update": {"dna_sequence": {"$update": {"accession": "CP003583.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Efac_liaR_DAP"}}, "755": {"$update": {"ARO_description": "KPC-9 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"5870": {"$update": {"dna_sequence": {"$update": {"accession": "FJ624872.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-9"}}, "3783": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "YajC"}}, "759": {"$update": {"ARO_description": "OCH-2 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi.", "model_sequences": {"$update": {"sequence": {"$update": {"1504": {"$update": {"dna_sequence": {"$update": {"accession": "AJ295340.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Brucella anthropi"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36233": {"$update": {"category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi."}}}}}, "$insert": {"CARD_short_name": "OCH-2"}}, "509": {"$update": {"ARO_description": "FOX-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"870": {"$update": {"dna_sequence": {"$update": {"accession": "X77455.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-1"}}, "3780": {"$insert": {"CARD_short_name": "ADC-159"}}, "1595": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3282": {"$update": {"dna_sequence": {"$update": {"accession": "AB498758.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mecB"}}, "506": {"$update": {"ARO_description": "IMP-5 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1191": {"$update": {"dna_sequence": {"$update": {"accession": "AF290912.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-5"}}, "3322": {"$update": {"ARO_description": "AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli."}, "$insert": {"CARD_short_name": "AAC(3)-IId"}}, "3781": {"$update": {"ARO_description": "PDC-65 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-65"}}, "1591": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1915": {"$update": {"dna_sequence": {"$update": {"accession": "HQ832678.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-64"}}, "1590": {"$update": {"ARO_description": "QnrB27 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii.", "model_sequences": {"$update": {"sequence": {"$update": {"156": {"$update": {"dna_sequence": {"$update": {"accession": "HM439641.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB27"}}, "3076": {"$insert": {"CARD_short_name": "dfrB4"}}, "507": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4555": {"$update": {"dna_sequence": {"$update": {"accession": "U46859.1"}}}}}}}}}, "$insert": {"CARD_short_name": "rosB"}}, "5455": {"$insert": {"CARD_short_name": "PDC-326"}}, "1599": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1560": {"$update": {"dna_sequence": {"$update": {"accession": "AF117747.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-23"}}, "1598": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1042": {"$update": {"dna_sequence": {"$update": {"accession": "AM412777.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-101"}}, "3787": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OmpA"}}, "1025": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1073": {"$update": {"dna_sequence": {"$update": {"accession": "AY826417.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-136"}}, "1024": {"$update": {"ARO_description": "AAC(6')-Ib-SK is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces kanamyceticus.", "model_sequences": {"$update": {"sequence": {"$update": {"360": {"$update": {"dna_sequence": {"$update": {"accession": "AB164230.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ib-SK"}}, "1027": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"732": {"$update": {"dna_sequence": {"$update": {"accession": "Y15510.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(H)"}}, "1031": {"$update": {"ARO_description": "APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum.", "model_sequences": {"$update": {"sequence": {"$update": {"467": {"$update": {"dna_sequence": {"$update": {"accession": "AF024602.1"}}}}}}}}, "ARO_category": {"$update": {"36290": {"$update": {"category_aro_description": "Phosphorylation of streptomycin on the hydroxyl group at position 6."}}}}}, "$insert": {"CARD_short_name": "APH(6)-Id"}}, "5340": {"$insert": {"CARD_short_name": "PDC-200"}}, "5341": {"$insert": {"CARD_short_name": "PDC-202"}}, "5342": {"$insert": {"CARD_short_name": "PDC-203"}}, "1022": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1958": {"$update": {"dna_sequence": {"$update": {"accession": "U37195.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-28"}}, "660": {"$update": {"ARO_description": "Point mutation in Streptococcus pneumoniae parC resulting in fluoroquinolone resistance.", "model_name": "Streptococcus pneumoniae parC conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Spne_parC_FLO"}}, "1036": {"$update": {"ARO_description": "Also known as vanWB, is a vanW variant found in the vanB gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3455": {"$update": {"dna_sequence": {"$update": {"accession": "U35369.1"}}}}}}}}, "model_name": "vanW gene in vanB cluster", "ARO_name": "vanW gene in vanB cluster"}, "$insert": {"CARD_short_name": "vanW_in_vanB_cl"}}, "3785": {"$insert": {"CARD_short_name": "mlaD"}}, "1029": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1360": {"$update": {"dna_sequence": {"$update": {"accession": "KF526115.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-102"}}, "1028": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1469": {"$update": {"dna_sequence": {"$update": {"accession": "FJ668814.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-1"}}, "1037": {"$update": {"ARO_description": "cmlA1 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa and Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8347": {"dna_sequence": {"partial": "0", "sequence": "GTGAGCTCAAAAAACTTTAGTTGGCGGTACTCCCTTGCCGCCACGGTGTTGTTGTTATCACCGTTCGATTTATTGGCATCACTCGGCATGGACATGTACTTGCCAGCAGTGCCGTTTATGCCAAACGCGCTTGGTACGACAGCGAGCACAATTCAGCTTACGCTGACAACGTACTTGGTCATGATTGGTGCCGGTCAGCTCTTGTTTGGACCGCTATCGGACCGACTGGGGCGCCGCCCCGTTCTACTGGGAGGTGGCCTCGCCTACGTTGTGGCGTCAATGGGCCTCGCTCTTACGTCATCGGCTGAAGTCTTTCTGGGGCTTCGGATTCTTCAGGCTTGTGGTGCCTCGGCGTGCCTTGTTTCCACATTTGCAACAGTACGTGACATTTACGCAGGTCGCGAGGAAAGTAATGTCATTTACGGCATACTCGGATCCATGCTGGCCATGGTCCCGGCGGTAGGCCCATTGCTCGGAGCGCTCGTCGACATGTGGCTTGGGTGGCGGGCTATCTTTGCGTTTCTAGGTTTGGGCATGATCGCTGCATCTGCAGCAGCGTGGCGATTCTGGCCTGAAACCCGGGTGCAACGAGTTGCGGGCTTGCAATGGTCGCAGCTGCTACTCCCCGTTAAGTGCCTGAACTTCTGGTTGTACACGTTGTGTTACGCCGCTGGAATGGGTAGCTTCTTCGTCTTTTTCTCCATTGCGCCCGGACTAATGATGGGCAGGCAAGGTGTGTCTCAGCTTGGCTTCAGCCTGCTGTTCGCCACAGTGGCAATTGCCATGGTGTTTACGGCTCGTTTTATGGGGCGTGTGATACCCAAGTGGGGCAGCCCAAGTGTCTTGCGAATGGGAATGGGATGCCTGATAGCTGGAGCAGTATTGCTTGCCATCACCGAAATATGGGCTTTGCAGTCCGTGTTAGGCTTTATTGCTCCAATGTGGCTAGTGGGTATTGGTGTCGCCACAGCGGTATCTGTGGCGCCCAATGGCGCTCTTCGAGGATTCGACCATGTTGCTGGAACGGTCACGGCAGTCTACTTCTGCTTGGGCGGTGTACTGCTAGGAAGCATCGGAACGTTGATCATTTCGCTGTTGCCGCGCAACACGGCTTGGCCGGTTGTCGTGTACTGTTTGACCCTTGCAACAGTCGTGCTCGGTCTGTCTTGTGTTTCCCGAGTGAAGGGCTCTCGCGGCCAGGGGGAGCATGATGTGGTCGCGCTACAAAGTGCGGGAAGTACATCAAATCCCAATCGTTGA", "fmax": "1860", "accession": "M64556.1", "fmin": "600", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AAA26057.1", "sequence": "MSSKNFSWRYSLAATVLLLSPFDLLASLGMDMYLPAVPFMPNALGTTASTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLGGGLAYVVASMGLALTSSAEVFLGLRILQACGASACLVSTFATVRDIYAGREESNVIYGILGSMLAMVPAVGPLLGALVDMWLGWRAIFAFLGLGMIAASAAAWRFWPETRVQRVAGLQWSQLLLPVKCLNFWLYTLCYAAGMGSFFVFFSIAPGLMMGRQGVSQLGFSLLFATVAIAMVFTARFMGRVIPKWGSPSVLRMGMGCLIAGAVLLAITEIWALQSVLGFIAPMWLVGIGVATAVSVAPNGALRGFDHVAGTVTAVYFCLGGVLLGSIGTLIISLLPRNTAWPVVVYCLTLATVVLGLSCVSRVKGSRGQGEHDVVALQSAGSTSNPNR"}}}}}}, "$insert": {"CARD_short_name": "cmlA1"}}, "1034": {"$update": {"ARO_description": "QnrA7 is a plasmid-mediated quinolone resistance protein found in Shewanella algae.", "model_sequences": {"$update": {"sequence": {"8202": {"dna_sequence": {"partial": "0", "sequence": "ATGGATATTATTGATAAAGTTTTTCAGCAAGAGGATTTCTCACGCCAGGATTTGAGCGACAGCCGTTTTCGCCGCTGCCGCTTTTATCAGTGTGACTTCAGCCATTGCCAGCTAAGGGATGCCAGTTTCGAGGATTGCAGTTTCATTGAAAGCGGCGCCGTCGAAGGGTGCCACTTCAGCTATGCCGATCTGCGCGATGCCAGTTTCAAGGCCTGCCGCCTGTCTTTGGCCAATTTCAGCGGTGCCAACTGCTTTGGCATAGAGTTCAGGGAGTGCGATCTCAAGGGCGCCAATTTTTCCCGGGCCCGTTTTTACAATCAAATCAGCCATAAGATGTACTTCTGCTCGGCTTATATCTCAGGCTGTAACCTGGCCTATGCCAATTTGAGCGGCCAATGCCTGGAAAAGTGCGAGCTGTTTGAAAACAACTGGAGCAATGCCAACCTCAGCGGCGCTTCCTTGATGGGCTCCGACCTCAGCCACGGCACCTTCTCCCGCGACTGCTGGCAACAGGTAAACCTGCGGGGCTGTGACCTGACCTTTGCCGATCTGGATGGGCTCGACCCCAGACGGGTCAACCTCGAAGGGGTCAAGATCTGTGCCTGGCAGCAGGAGCAACTGCTGGAACCCTTGGGAGTCATAGTGCTGCCGGATTAG", "fmax": "657", "accession": "GQ463707.3", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shewanella algae", "NCBI_taxonomy_id": "38313", "NCBI_taxonomy_cvterm_id": "36891"}, "protein_sequence": {"accession": "ACV83303.2", "sequence": "MDIIDKVFQQEDFSRQDLSDSRFRRCRFYQCDFSHCQLRDASFEDCSFIESGAVEGCHFSYADLRDASFKACRLSLANFSGANCFGIEFRECDLKGANFSRARFYNQISHKMYFCSAYISGCNLAYANLSGQCLEKCELFENNWSNANLSGASLMGSDLSHGTFSRDCWQQVNLRGCDLTFADLDGLDPRRVNLEGVKICAWQQEQLLEPLGVIVLPD"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrA7"}}, "5456": {"$insert": {"CARD_short_name": "PDC-327"}}, "1035": {"$update": {"ARO_description": "PBP2b is a penicillin-binding protein found in Streptococcus pneumoniae.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40661": {"$update": {"category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}}}}}, "$insert": {"CARD_short_name": "Spne_PBP2b_AMX"}}, "3951": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 19-SEP-2016.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-196"}}, "605": {"$update": {"ARO_description": "OXA-96 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1617": {"$update": {"dna_sequence": {"$update": {"accession": "DQ519090.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-96"}}, "604": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4575": {"$update": {"dna_sequence": {"$update": {"accession": "KF986253.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-385"}}, "607": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1884": {"$update": {"dna_sequence": {"$update": {"accession": "JX310327.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-201"}}, "606": {"$update": {"ARO_description": "IMI-2 is a beta-lactamase found in Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"1277": {"$update": {"dna_sequence": {"$update": {"accession": "DQ173429.1"}}}}}}}}}, "$insert": {"CARD_short_name": "IMI-2"}}, "601": {"$update": {"ARO_description": "dfrA20 is a plasmid-encoded dihydrofolate reductase found in Pasteurella multocida.", "model_sequences": {"$update": {"sequence": {"$update": {"342": {"$update": {"dna_sequence": {"$update": {"accession": "AJ605332.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA20"}}, "600": {"$update": {"ARO_description": "CMY-2 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"821": {"$update": {"dna_sequence": {"$update": {"accession": "X91840.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CMY-2"}}, "603": {"$insert": {"CARD_short_name": "mdtG"}}, "4362": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6737": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ANA-1"}}, "1205": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1807": {"$update": {"dna_sequence": {"$update": {"accession": "KF131539.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-39"}}, "1207": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"770": {"$update": {"dna_sequence": {"$update": {"accession": "KM087855.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-13"}}, "1206": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"398": {"$update": {"dna_sequence": {"$update": {"accession": "JQ064560.1"}}}}}}}}, "model_name": "QepA1"}, "$insert": {"CARD_short_name": "QepA1"}}, "1201": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-22"}}, "608": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2010": {"$update": {"dna_sequence": {"$update": {"accession": "KF460531.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-361"}}, "1203": {"$update": {"model_name": "Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid"}, "$insert": {"CARD_short_name": "Mtub_ndh_INH"}}, "1202": {"$update": {"ARO_description": "CTX-M-28 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"1780": {"$update": {"dna_sequence": {"$update": {"accession": "AJ549244.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-28"}}, "5649": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8024": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SGM-6"}}, "5648": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8023": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SGM-5"}}, "1211": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1962": {"$update": {"dna_sequence": {"$update": {"accession": "AF317511.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-1"}}, "5457": {"$insert": {"CARD_short_name": "PDC-328"}}, "5641": {"$insert": {"CARD_short_name": "RUB-1"}}, "5640": {"$insert": {"CARD_short_name": "RSD2-2"}}, "5643": {"$insert": {"CARD_short_name": "SFO-1"}}, "5642": {"$insert": {"CARD_short_name": "SFC-1"}}, "5645": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8020": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SGM-2"}}, "5644": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8019": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SGM-1"}}, "5647": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8022": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SGM-4"}}, "4276": {"$insert": {"CARD_short_name": "ADC-211"}}, "5422": {"$insert": {"CARD_short_name": "PDC-290"}}, "1214": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"925": {"$update": {"dna_sequence": {"$update": {"accession": "AY574271.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-134"}}, "1215": {"$update": {"ARO_description": "FosC is an enzyme that phosphorylates fosfomycin to confer resistance.", "model_sequences": {"$update": {"sequence": {"$update": {"481": {"$update": {"dna_sequence": {"$update": {"accession": "Z33413.1"}}}}}}}}}, "$insert": {"CARD_short_name": "FosC"}}, "3325": {"$update": {"ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS12"}}, "1447": {"$update": {"ARO_description": "OKP-A-10 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"794": {"$update": {"dna_sequence": {"$update": {"accession": "AM051149.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-10"}}, "1110": {"$update": {"ARO_description": "LEN-19 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8274": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGGTCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM850909.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12347.2", "sequence": "MRYVRLCVISLLATLPLAVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTVGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-19"}}, "1113": {"$update": {"ARO_description": "ANT(6)-Ib is an aminoglycoside nucleotidyltransferase gene encoded by transferable pathogenicity islands in C. fetus subsp. fetus and B. subtilis.", "model_sequences": {"$update": {"sequence": {"$update": {"60": {"$update": {"dna_sequence": {"$update": {"accession": "FN594949.1"}}}}}}}}, "ARO_category": {"$update": {"36364": {"$update": {"category_aro_description": "Nucelotidylylation of streptomycin at the hydroxyl group at position 6."}}}}}, "$insert": {"CARD_short_name": "ANT(6)-Ib"}}, "1444": {"$update": {"ARO_description": "IND-12 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1826": {"$update": {"dna_sequence": {"$update": {"accession": "HM245380.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-12"}}, "1443": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1814": {"$update": {"dna_sequence": {"$update": {"accession": "AF409092.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-7"}}, "1114": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1418": {"$update": {"dna_sequence": {"$update": {"accession": "KF992026.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-17"}}, "1441": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2109": {"$update": {"dna_sequence": {"$update": {"accession": "AF335467.1"}}}}}}}}, "model_name": "Klebsiella aerogenes Omp36", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Kaer_Omp36"}}, "1116": {"$update": {"ARO_description": "arr-2 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"480": {"$update": {"dna_sequence": {"$update": {"accession": "AF078527.1"}}}}}}}}}, "$insert": {"CARD_short_name": "arr-2"}}, "1119": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2046": {"$update": {"dna_sequence": {"$update": {"accession": "AF416700.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "EBR-1", "ARO_name": "EBR-1"}, "$insert": {"CARD_short_name": "EBR-1"}}, "1118": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-2"}}, "1351": {"$update": {"ARO_description": "QnrVC1 is an integron-mediated quinolone resistance protein found in Vibrio cholerae.", "model_sequences": {"$update": {"sequence": {"8213": {"dna_sequence": {"partial": "0", "sequence": "ATGGAAAAATCAAAGCAATTATATAATCAAGTGAACTTCTCACATCAGGACTTGCAAGAACATATCTTTAGCAATTGTACTTTTATACATTGTAATTTTAAGCGCTCAAACCTCCGAGATACACAGTTCATTAACTGTACTTTCATAGAGCAGGGGGCATTGGAAGGGTGCGATTTTTCTTATGCTGATCTTCGAGATGCTTCATTTAAAAACTGTCAGCTTTCAATGTCCCATTTTAAGGGGGCAAATTGCTTTGGTATTGAACTGAGAGATTGTGATCTTAAAGGAGCAAATTTTAGTCAAGTTAGTTTTGTAAATCAGGTTTCGAATAAAATGTACTTTTGTTCTGCATACATAACAGGTTGTAACTTATCCTATGCCAATTTTGAGCAGCAGCTTATTGAAAAATGTGACCTGTTCGAAAATAGATGGATTGGTGCAAATCTTCGAGGCGCTTCATTTAAAGAATCAGATTTAAGCCGTGGTGTTTTTTCGGAAGACTGCTGGGAACAGTTTAGAGTACAAGGCTGTGATTTAAGCCATTCAGAGCTTTATGGTTTAGATCCTCGAAAGATTGATCTTACGGGTGTAAAAATATGCTCGTGGCAACAGGAACAGTTACTGGAGCAATTAGGGGTAATCATTGTTCCTGACTAA", "fmax": "2058", "accession": "EU436855.2", "fmin": "1401", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Vibrio cholerae", "NCBI_taxonomy_id": "666", "NCBI_taxonomy_cvterm_id": "36789"}, "protein_sequence": {"accession": "ACC54440.2", "sequence": "MEKSKQLYNQVNFSHQDLQEHIFSNCTFIHCNFKRSNLRDTQFINCTFIEQGALEGCDFSYADLRDASFKNCQLSMSHFKGANCFGIELRDCDLKGANFSQVSFVNQVSNKMYFCSAYITGCNLSYANFEQQLIEKCDLFENRWIGANLRGASFKESDLSRGVFSEDCWEQFRVQGCDLSHSELYGLDPRKIDLTGVKICSWQQEQLLEQLGVIIVPD"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrVC1"}}, "1449": {"$update": {"ARO_description": "OXA-59 is a beta-lactamase found in Burkholderia pseudomallei.", "model_sequences": {"$update": {"sequence": {"$update": {"1304": {"$update": {"dna_sequence": {"$update": {"accession": "AJ632249.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-59"}}, "1448": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1789": {"$update": {"dna_sequence": {"$update": {"accession": "AF227204.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-26"}}, "4093": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-29 [Klebsiella pneumoniae] Accession: WP_096807439.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-29"}}, "4092": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-27 [Klebsiella pneumoniae] Accession: WP_077064886.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-27"}}, "4091": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-18"}}, "4278": {"$insert": {"CARD_short_name": "ADC-213"}}, "4097": {"$update": {"ARO_description": "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-30 [Klebsiella pneumoniae] Accession: WP_085562399.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-30"}}, "4096": {"$update": {"ARO_description": "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-32 [Klebsiella pneumoniae] Accession: WP_073800284.1.", "model_sequences": {"$update": {"sequence": {"$update": {"6470": {"$update": {"dna_sequence": {"$update": {"accession": "MAPO01000050.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-32"}}, "4095": {"$update": {"ARO_description": "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-31 [Klebsiella] Accession: WP_073668892.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-31"}}, "4094": {"$update": {"ARO_description": "Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-28 [Escherichia coli] Accession: WP_072081992.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-28"}}, "5068": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-759"}}, "2401": {"$update": {"ARO_description": "Point mutation of Haemophilus parainfluenzae gyrA resulted in the lowered affinity between fluoroquinolones and GyrA. Thus, conferring resistance. Both Ser and Tyr are hydrophilic amino acids, however Tyr has an additional bulky hydrophobic group which could affect the interaction between the DNA gyrase with quinolones."}, "$insert": {"CARD_short_name": "Hpin_gyrA_FLO"}}, "4099": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-34 [Klebsiella pneumoniae] Accession: WP_109545044.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-34"}}, "4098": {"$update": {"ARO_description": "Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-33 [Klebsiella pneumoniae] Accession: WP_101140102.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-33"}}, "2059": {"$update": {"ARO_description": "OKP-A-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8147": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCCGCCGCTTGAGCAAATTACACGCAGCGAAAGTCAGCTGGCGGGCCGCGTGGGCTATGTTGAAATGGATCTGGTCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAATGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGAGACGAACAGCTGGATCGGCGGATCCGCTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTTGGCGGCCCCGCTGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAGCTCAATGAAGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCAGCCAGCATGGCCGCCACCCTGCGCAAGCTGCTAACCAGCCACACTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCAGGTAGCCGGTCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGAAAAAACCGGGGCCGGCGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGAACGGCAAAGCGGAGCGCATCGTGGTGATCTATCTGCGGGATACGCCGGCGTCCATGGCCGAGCGTAACCAGCAGATCGCCAGAATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAG", "fmax": "861", "accession": "AJ635401.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAG25812.2", "sequence": "MRYVRLCLISLIAALPLAVFASPPPLEQITRSESQLAGRVGYVEMDLVSGRTLAAWRANERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIRYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMAATLRKLLTSHTLSARSQQQLLQWMVDDQVAGPLIRAVLPAGWFIAEKTGAGERGSRGIVALLGPNGKAERIVVIYLRDTPASMAERNQQIARIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-1"}}, "4585": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6960": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "EAM-1"}}, "1355": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2032": {"$update": {"dna_sequence": {"$update": {"accession": "DQ369751.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-149"}}, "489": {"$update": {"ARO_description": "Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant.", "model_sequences": {"$update": {"sequence": {"8134": {"dna_sequence": {"partial": "0", "sequence": "ATGTCTCCGATCGAGCCCGCGGCGTCTGCGATCTTCGGACCGCGGCTTGGCCTTGCTCGGCGGTACGCCGAAGCGTTGGCGGGACCCGGTGTGGAGCGGGGGCTGGTGGGACCCCGCGAAGTCGGTAGGCTATGGGACCGGCATCTACTGAACTGCGCCGTGATCGGTGAGCTCCTCGAACGCGGTGACCGGGTCGTGGATATCGGTAGCGGAGCCGGGTTGCCGGGCGTGCCATTGGCGATAGCGCGGCCGGACCTCCAGGTAGTTCTCCTAGAACCGCTACTGCGCCGCACCGAGTTTCTTCGAGAGATGGTGACAGATCTGGGCGTGGCCGTTGAGATCGTGCGGGGGCGCGCCGAGGAGTCCTGGGTGCAGGACCAATTGGGCGGCAGCGACGCTGCGGTGTCACGGGCGGTGGCCGCGTTGGACAAGTTGACGAAATGGAGCATGCCGTTGATACGGCCGAACGGGCGAATGCTCGCCATCAAAGGCGAGCGGGCTCACGACGAAGTACGGGAGCACCGGCGTGTGATGATCGCATCGGGCGCGGTTGATGTCAGGGTGGTGACATGTGGCGCGAACTATTTGCGTCCGCCCGCGACCGTGGTGTTCGCACGACGTGGAAAGCAGATCGCCCGAGGGTCGGCACGGATGGCGAGTGGAGGGACGGCGTGA", "fmax": "4408202", "accession": "AL123456.3", "fmin": "4407527", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332", "NCBI_taxonomy_cvterm_id": "39507"}, "protein_sequence": {"accession": "CCP46748.1", "sequence": "MSPIEPAASAIFGPRLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLERGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGVAVEIVRGRAEESWVQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVREHRRVMIASGAVDVRVVTCGANYLRPPATVVFARRGKQIARGSARMASGGTA"}}}}}, "ARO_category": {"$update": {"40059": {"$update": {"category_aro_description": "GidB is a m7G methyltransferase specific for 16S rRNA. Mutations within the gidB gene causes changes in the structure or 16s rRNA, leading to resistance to aminoglycosides."}}}}}, "$insert": {"CARD_short_name": "Mtub_gidB_STR"}}, "488": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1558": {"$update": {"dna_sequence": {"$update": {"accession": "JX121123.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-156"}}, "487": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"539": {"$update": {"dna_sequence": {"$update": {"accession": "AY768532.1"}}}}}}}}}, "$insert": {"CARD_short_name": "macB"}}, "486": {"$update": {"ARO_description": "cmlB is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella aerogenes.", "model_sequences": {"$update": {"sequence": {"8250": {"dna_sequence": {"partial": "1", "sequence": "GAATTGCTTGAGAATTGTTACGATTCAAATTCAGCCATGAGATAGTCAGCAAATGAGCACTTCCAAGAAAGCAGACAAGTAAGCCGCAGCAACCTTCATTTTTCGGTTGTTGCGGCGTTCTCATGAACCCTTTTGCTCTACGGGAGCGCCGCCAAATCCTTCGTTCAAGGAGATGGTTTCGTGCGCTCAAAGAACTGTAATTGGCGGTATTCCCTTGCCGTCACTGTGTTGTTGTTATCACCTTTCGATTTACTGGCATCACTCGGCATGGACATGTACTTGCCAGCGGTGCCTTTCATGCCACATGCTCTTGGTACGACAGCGGGCACAATTCAGCTTACGCTGACAACGTATTTGGTCATGATAGGGGCCGGTCAGCTTTTGTTTGGGCCACTGTCGGACCGGCTGGGACGTCGTCCCGTGCTACTGGCGGGCGGTGCCGCCTACGTTGCGGCCTCAATCGGCCTCGTCGTCACGTCATCGGCTGGAGTATTTCTGGGTTTTCGGATTCTCCAAGCTTGTGGTGCCTCGGCATGCCTTGTTGCCACATTTGCAACAGTGCGTGATATCTACGCAGGTCGCAAGGAAAGTAACGTCATCTACGGCTTGCTTGGCTCTATGCTTGCTATGGTTCCGGCGATAGGCCCATTGCTGGGAGCGGTCATAGACACCTGGTTCGGGTGGCGGGCGATCTTTGCGTTCTTGGGATTGGGAATGATCGCTGCATTGACAGCAGCGTGGCGGCTCTGGCCTGAGACCCGGGTGCAGCGACCAGCAGCTTTGCAATGGTCACAACTTCTGCTTCCCATCAAGCACCTTAACTTCTGGTTGTACACAGTGTGTTATGCCGCAGGAATGGGCAGCTTCTTCGTCTTCTTCTCCATAGCGCCCGGATTGATGATGGGTAGGCAAGGCATGTCCCAGTTTGGCTTCAGTCTGTTGTTCGCAACAGTGGCAATTGCGATGATGCTTGCGGCCCGCTTCATGGGGCGCGTAATCGCCAAGTGGGGCAGCCTGAGTGCCTTGCGAATGGGGATGGGCTGCCTGATAGCAGGCGCAGTCTTGCTTGTCATCACCGAGCTATGGATTCCGCAGTCCGTGTTGGGCTTTATTGCCCCAATGTGGCTAGTGGGCGTCGGCGTCGCGACAGCGGTATCCGTTGCACCCAATGGTGCGCTTCGAGGGTTCGACCATATTGCAGGAGCCGTTACGGCAGTCTACTTCTGCTTGGGGGGGCTGCTGCTGGGGAGTGTTGGAACGCTCATCATTTCGCTGTTGCCGCGCGACACGGCCTGGCCAGTTATCGCGTATTGTTTGGTTCTTGCAACAATCGTGCTTGGACTGTCGTGTGTTTCCCGAGCGAGAGACCTTCGCGGTCACGGGGAGTATGATGCGGTTGCACGCACATAG", "fmax": "3871", "accession": "AF034958.3", "fmin": "2461", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella aerogenes", "NCBI_taxonomy_id": "548", "NCBI_taxonomy_cvterm_id": "36770"}, "protein_sequence": {"accession": "AAD22144.1", "sequence": "MRSKNCNWRYSLAVTVLLLSPFDLLASLGMDMYLPAVPFMPHALGTTAGTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLAGGAAYVAASIGLVVTSSAGVFLGFRILQACGASACLVATFATVRDIYAGRKESNVIYGLLGSMLAMVPAIGPLLGAVIDTWFGWRAIFAFLGLGMIAALTAAWRLWPETRVQRPAALQWSQLLLPIKHLNFWLYTVCYAAGMGSFFVFFSIAPGLMMGRQGMSQFGFSLLFATVAIAMMLAARFMGRVIAKWGSLSALRMGMGCLIAGAVLLVITELWIPQSVLGFIAPMWLVGVGVATAVSVAPNGALRGFDHIAGAVTAVYFCLGGLLLGSVGTLIISLLPRDTAWPVIAYCLVLATIVLGLSCVSRARDLRGHGEYDAVART"}}}}}}, "$insert": {"CARD_short_name": "cmlB"}}, "485": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-191"}}, "484": {"$update": {"ARO_description": "QnrB49 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"214": {"$update": {"dna_sequence": {"$update": {"accession": "JQ582718.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB49"}}, "483": {"$update": {"ARO_description": "GES-7 is a beta-lactamase found in Enterobacter cloacae.", "model_sequences": {"$update": {"sequence": {"8194": {"dna_sequence": {"partial": "0", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCATCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCAAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGGGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "fmax": "5341", "accession": "AY260546.3", "fmin": "4477", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAP22974.1", "sequence": "MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-7"}}, "482": {"$update": {"ARO_description": "LEN-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"776": {"$update": {"dna_sequence": {"$update": {"accession": "X04515.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-1"}}, "481": {"$update": {"ARO_description": "VIM-30 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1083": {"$update": {"dna_sequence": {"$update": {"accession": "JN129451.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-30"}}, "480": {"$update": {"ARO_description": "GES-9 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"871": {"$update": {"dna_sequence": {"$update": {"accession": "AY920928.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-9"}}, "5555": {"$insert": {"CARD_short_name": "PDC-425"}}, "4586": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "EBR-3"}}, "4853": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7228": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-518"}}, "5176": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-879"}}, "451": {"$update": {"ARO_description": "LRA-5 is a beta-lactamase isolated from soil samples in Alaska.", "model_sequences": {"$update": {"sequence": {"$update": {"4540": {"$update": {"dna_sequence": {"$update": {"accession": "EU408358.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-5"}}, "4827": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-395"}}, "4852": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-517"}}, "4725": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-62"}}, "4379": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-18"}}, "4851": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-516"}}, "4724": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-49"}}, "4143": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-52"}}, "4142": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-51"}}, "3856": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-846"}}, "3857": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-29"}}, "3854": {"$insert": {"CARD_short_name": "PDC-47"}}, "3855": {"$insert": {"CARD_short_name": "PDC-51"}}, "3852": {"$insert": {"CARD_short_name": "PDC-66"}}, "3853": {"$insert": {"CARD_short_name": "PDC-14"}}, "3850": {"$insert": {"CARD_short_name": "PDC-63"}}, "3851": {"$insert": {"CARD_short_name": "PDC-57"}}, "5651": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8026": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SHN-1"}}, "3858": {"$insert": {"CARD_short_name": "PDC-11"}}, "3859": {"$insert": {"CARD_short_name": "PDC-62"}}, "4497": {"$insert": {"CARD_short_name": "CTX-M-168"}}, "1487": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"991": {"$update": {"dna_sequence": {"$update": {"accession": "AY263404.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-48"}}, "252": {"$update": {"ARO_description": "APH(9)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in L. pneumophila.", "model_sequences": {"$update": {"sequence": {"$update": {"514": {"$update": {"dna_sequence": {"$update": {"accession": "U94857.1"}}}}}}}}, "ARO_category": {"$update": {"36292": {"$update": {"category_aro_description": "Phosphorylation of spectinomycin on the hydroxyl group at position 9."}}}}}, "$insert": {"CARD_short_name": "APH(9)-Ia"}}, "4814": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114n"}}, "5239": {"$insert": {"CARD_short_name": "PAU-1"}}, "3294": {"$insert": {"CARD_short_name": "erm(32)"}}, "5403": {"$insert": {"CARD_short_name": "PDC-267"}}, "924": {"$update": {"ARO_description": "AAC(6')-33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"362": {"$update": {"dna_sequence": {"$update": {"accession": "JN596280.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-33"}}, "16": {"$update": {"ARO_description": "KPC-10 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1633": {"$update": {"dna_sequence": {"$update": {"accession": "GQ140348.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-10"}}, "4304": {"$insert": {"CARD_short_name": "ADC-239"}}, "2288": {"$update": {"model_name": "Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid"}, "$insert": {"CARD_short_name": "Mbov_ndh_INH"}}, "456": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"711": {"$update": {"dna_sequence": {"$update": {"accession": "HM440348.1"}}}}}}}}}, "$insert": {"CARD_short_name": "adeR"}}, "2896": {"$update": {"ARO_description": "A chloramphenicol resistance determinant described in Staphylococcus intermedius.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Sint_ACT_CHL"}}, "199": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1718": {"$update": {"dna_sequence": {"$update": {"accession": "AB008454.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SRT-1"}}, "198": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1242": {"$update": {"dna_sequence": {"$update": {"accession": "AY853593.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-138"}}, "195": {"$update": {"ARO_description": "CTX-M-58 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1705": {"$update": {"dna_sequence": {"$update": {"accession": "EF210159.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-58"}}, "194": {"$update": {"model_sequences": {"$update": {"sequence": {"8137": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCGGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AJ866284.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAI30650.2", "sequence": "MRYIRRCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-61"}}, "197": {"$update": {"ARO_description": "CTX-M-56 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1629": {"$update": {"dna_sequence": {"$update": {"accession": "EF374097.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-56"}}, "196": {"$update": {"ARO_description": "Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol.", "model_sequences": {"$update": {"sequence": {"$update": {"2078": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}, "model_name": "Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol"}, "$insert": {"CARD_short_name": "Mtub_embB_EMB"}}, "191": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1047": {"$update": {"dna_sequence": {"$update": {"accession": "JN704570.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-199"}}, "190": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2003": {"$update": {"dna_sequence": {"$update": {"accession": "HQ425493.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-195"}}, "193": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1154": {"$update": {"dna_sequence": {"$update": {"accession": "AY271267.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-121"}}, "192": {"$update": {"ARO_description": "CTX-M-38 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1352": {"$update": {"dna_sequence": {"$update": {"accession": "AY822595.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-38"}}, "19": {"$update": {"ARO_description": "IMP-2 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1091": {"$update": {"dna_sequence": {"$update": {"accession": "AJ243491.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-2"}}, "4558": {"$insert": {"CARD_short_name": "CTX-M-229"}}, "4559": {"$insert": {"CARD_short_name": "CTX-M-230"}}, "4556": {"$insert": {"CARD_short_name": "CTX-M-227"}}, "4557": {"$insert": {"CARD_short_name": "CTX-M-228"}}, "4554": {"$insert": {"CARD_short_name": "CTX-M-225"}}, "4555": {"$insert": {"CARD_short_name": "CTX-M-226"}}, "4552": {"$insert": {"CARD_short_name": "CTX-M-223"}}, "4553": {"$insert": {"CARD_short_name": "CTX-M-224"}}, "4550": {"$insert": {"CARD_short_name": "CTX-M-221"}}, "4551": {"$insert": {"CARD_short_name": "CTX-M-222"}}, "1454": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"781": {"$update": {"dna_sequence": {"$update": {"accession": "KM087837.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-112"}}, "1455": {"$update": {"ARO_description": "IND-9 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1417": {"$update": {"dna_sequence": {"$update": {"accession": "GU186045.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-9"}}, "141": {"$update": {"ARO_description": "Also known as vanRB, is a vanR variant found in the vanB gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3453": {"$update": {"dna_sequence": {"$update": {"accession": "U35369.1"}}}}}}}}, "model_name": "vanR gene in vanB cluster", "ARO_name": "vanR gene in vanB cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanB_cl"}}, "1456": {"$update": {"ARO_description": "IMP-15 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"772": {"$update": {"dna_sequence": {"$update": {"accession": "AY553333.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-15"}}, "464": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1918": {"$update": {"dna_sequence": {"$update": {"accession": "LC012596.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-13"}}, "18": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1048": {"$update": {"dna_sequence": {"$update": {"accession": "JN861780.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-212"}}, "2381": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5196": {"$update": {"protein_sequence": {"$update": {"accession": "CAG39240.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Saur_UhpT_FOF"}}, "2380": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5195": {"$update": {"protein_sequence": {"$update": {"accession": "CAG39357.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Saur_GlpT_FOF"}}, "2383": {"$update": {"ARO_description": "Kanamycin nucleotidyltransferase sequence from Staphylococcus aureus plasmid. Confers resistance to kanamycin, neomycin and other aminoglycosides.", "ARO_category": {"$update": {"36368": {"$update": {"category_aro_description": "Nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 4'."}}}}}, "$insert": {"CARD_short_name": "ANT(4')-Ib"}}, "1457": {"$update": {"ARO_description": "CTX-M-13 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"8220": {"dna_sequence": {"partial": "0", "sequence": "ATGGTGACAAAGAGAATGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTGCTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCAAAGATAATACGCAGGTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCAAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATGACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGAGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGTGGGTGATAAGACCGGCAGCGGCGACTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTGGTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTGGCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA", "fmax": "876", "accession": "AF252623.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAF72531.1", "sequence": "MVTKRMQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTKDNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFAREIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-13"}}, "2387": {"$insert": {"CARD_short_name": "Erm(47)"}}, "2386": {"$update": {"ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "cipA"}}, "1450": {"$update": {"ARO_description": "Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance.", "model_name": "Escherichia coli parC conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Ecol_parC_FLO"}}, "1451": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1658": {"$update": {"dna_sequence": {"$update": {"accession": "LN515535.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-17"}}, "3580": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "DES-1"}}, "3581": {"$update": {"model_sequences": {"$update": {"sequence": {"8353": {"dna_sequence": {"partial": "0", "sequence": "ATGACAAAATCTGTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCAGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCATTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "fmax": "2091", "accession": "KJ207201.1", "fmin": "951", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Morganella morganii", "NCBI_taxonomy_id": "582", "NCBI_taxonomy_cvterm_id": "36917"}, "protein_sequence": {"accession": "AHL39320.1", "sequence": "MTKSVSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSHYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE"}}}}}}, "$insert": {"CARD_short_name": "DHA-9"}}, "2769": {"$update": {"ARO_description": "MdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type.", "model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "MdtNOP"}}, "3583": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FAR-1"}}, "3584": {"$update": {"model_sequences": {"$update": {"sequence": {"8351": {"dna_sequence": {"partial": "0", "sequence": "ATGCGCCCCTTACCCCATTCATACCTAAAGAGTCTTGTCATTTGCCTGCTGACGGCCTTCGCCGCCTTAACACCCGTCGTGAACTCTGGCGTACAAGCGGCTCAACCCAAAGACGTGCCGGTAACGTTTACCGCTATTACGCAGGGGGTGTGGATGCACACCAGCATGAAGCACATGGAAAACTGGGGGCATGTACCCAGTAACGGGCTAATCGTTGAAAAAGGAGACTTTAGTATTTTGGTGGATACGGCTTGGGACGATCCACAAACGGCACAGATTATTGAGTGGTCCAAAGATACGCTAAAAAAACCCATTCGTTGGGCGGTGTTTACCCATGCCCACGACGACAAAATGGGCGGGGTGGCTGCCTTACGACAGCAGGGCATTGTGACCTATGCGGCGGCCGACTCTAATCGAATGGCCCCACAGAATGGCTTAACCCCTGCAGAGCATGACCTCATCTTTGATAGCGAGCACAGCACAAGCGTTCTGCATCCGCTGGTCATTTTCGATCCCGGCCCAGGGCATACCCGCGACAATATTGTGGTGGGCCTGCCCGAGCAAGGGATTGTTTTTGGAGGCTGTCTCATTCGCCCATCGGGCAGCACGTCTCTGGGAAACACCGCTGACGCCGATCTCGCTCACTGGAAAACAGCGGTATTGGCCGTTGCGCAGCGCTTTGCGGAGGCCCAACAGATTATACCCAGCCACGGACCCATGGCCGGACGAGAGCTTTTTGAACTGACGGCTCAGCTGGCAGAAAAGGCCAGCATACCGTCCACACCCTGA", "fmax": "2725", "accession": "JX570731.1", "fmin": "1936", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AFV91534.1", "sequence": "MRPLPHSYLKSLVICLLTAFAALTPVVNSGVQAAQPKDVPVTFTAITQGVWMHTSMKHMENWGHVPSNGLIVEKGDFSILVDTAWDDPQTAQIIEWSKDTLKKPIRWAVFTHAHDDKMGGVAALRQQGIVTYAAADSNRMAPQNGLTPAEHDLIFDSEHSTSVLHPLVIFDPGPGHTRDNIVVGLPEQGIVFGGCLIRPSGSTSLGNTADADLAHWKTAVLAVAQRFAEAQQIIPSHGPMAGRELFELTAQLAEKASIPSTP"}}}}}}, "$insert": {"CARD_short_name": "FIM-1"}}, "5006": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-694"}}, "3586": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FONA-2"}}, "3587": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FONA-3"}}, "3588": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FONA-4"}}, "3589": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FONA-5"}}, "2761": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "MexPQ-OpmE"}}, "5008": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-696"}}, "2766": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "EmrKY-TolC"}}, "2765": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "EmrAB-TolC"}}, "3668": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase and NDM-1 variant.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-27"}}, "3379": {"$update": {"ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-VIIIa"}}, "5428": {"$insert": {"CARD_short_name": "PDC-298"}}, "1486": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1912": {"$update": {"dna_sequence": {"$update": {"accession": "D13210.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-12"}}, "902": {"$update": {"ARO_description": "OXA-92 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1427": {"$update": {"dna_sequence": {"$update": {"accession": "DQ335566.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-92"}}, "903": {"$update": {"ARO_description": "APH('')-Ig is a plasmid-encoded aminoglycoside phosphotransferase in Campylobacter coli.", "ARO_category": {"$update": {"36267": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''."}}}}}, "$insert": {"CARD_short_name": "APH(2'')-Ig"}}, "900": {"$insert": {"CARD_short_name": "tet(C)"}}, "1848": {"$update": {"ARO_description": "CTX-M-75 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1743": {"$update": {"dna_sequence": {"$update": {"accession": "GQ149244.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-75"}}, "906": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1264": {"$update": {"dna_sequence": {"$update": {"accession": "CP006005.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-21"}}, "907": {"$update": {"ARO_description": "fexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus.", "model_sequences": {"$update": {"sequence": {"$update": {"490": {"$update": {"dna_sequence": {"$update": {"accession": "AJ549214.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Mammaliicoccus lentus"}}}}}}}}}, "$insert": {"CARD_short_name": "fexA"}}, "904": {"$insert": {"CARD_short_name": "rmtB"}}, "4621": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-38"}}, "1843": {"$insert": {"CARD_short_name": "rmtD"}}, "4423": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-38"}}, "908": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"866": {"$update": {"dna_sequence": {"$update": {"accession": "KC107824.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-139"}}, "909": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1844": {"$update": {"dna_sequence": {"$update": {"accession": "X58272.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-5"}}, "1847": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"20": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}}, "$insert": {"CARD_short_name": "emrB"}}, "1846": {"$update": {"ARO_description": "CTX-M-91 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1864": {"$update": {"dna_sequence": {"$update": {"accession": "GQ870432.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-91"}}, "1845": {"$update": {"ARO_description": "OXA-312 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1298": {"$update": {"dna_sequence": {"$update": {"accession": "KF057029.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-312"}}, "1844": {"$update": {"ARO_description": "OXA-128 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1368": {"$update": {"dna_sequence": {"$update": {"accession": "EU375515.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-128"}}, "4308": {"$insert": {"CARD_short_name": "ADC-242"}}, "4958": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-632"}}, "4959": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-633"}}, "5402": {"$insert": {"CARD_short_name": "PDC-266"}}, "4952": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-626"}}, "4953": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-627"}}, "4950": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-624"}}, "4951": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-625"}}, "4956": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-630"}}, "4957": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-631"}}, "4954": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-628"}}, "4625": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-42"}}, "5233": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-949"}}, "2614": {"$update": {"ARO_description": "mphE is a macrolide phosphotransferase and resistance gene identified on a plasmid, pRSB105."}, "$insert": {"CARD_short_name": "mphE"}}, "4626": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-43"}}, "2147": {"$update": {"ARO_description": "Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa."}, "$insert": {"CARD_short_name": "Ecol_EFTu_ENC"}}, "4627": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-44"}}, "4082": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6455": {"$update": {"dna_sequence": {"$update": {"accession": "NG_052167.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DfrB9"}}, "3255": {"$update": {"ARO_description": "A dihydrofolate reductase and antibiotic resistance gene identified from an integron in Vibrio cholerae."}, "$insert": {"CARD_short_name": "dfrA6"}}, "4083": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6456": {"$update": {"dna_sequence": {"$update": {"accession": "NG_070722.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DfrA39"}}, "3298": {"$update": {"ARO_description": "KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Kpne_KpnG"}}, "1944": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1351": {"$update": {"dna_sequence": {"$update": {"accession": "KJ020574.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-148"}}, "1908": {"$update": {"ARO_description": "OKP-A-6 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1675": {"$update": {"dna_sequence": {"$update": {"accession": "AM051144.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-6"}}, "1909": {"$update": {"ARO_description": "AAC(6')-Iak is a 6'-N-aminoglycoside acetyltransferase-encoding gene isolated from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia."}, "$insert": {"CARD_short_name": "AAC(6')-Iak"}}, "5137": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-836"}}, "5136": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-834"}}, "3296": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5168": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Mammaliicoccus fleurettii"}}}}}}}}, "model_name": "erm(45)"}, "$insert": {"CARD_short_name": "erm(45)"}}, "1905": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1854": {"$update": {"dna_sequence": {"$update": {"accession": "KF526118.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-21"}}, "1902": {"$update": {"ARO_description": "OXA-246 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"886": {"$update": {"dna_sequence": {"$update": {"accession": "KF711993.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-246"}}, "3291": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5160": {"$update": {"dna_sequence": {"$update": {"accession": "LT223129.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Erm(48)"}}, "1900": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1094": {"$update": {"dna_sequence": {"$update": {"accession": "HE819402.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-13"}}, "5130": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-828"}}, "3452": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-288"}}, "855": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1490": {"$update": {"dna_sequence": {"$update": {"accession": "DQ388882.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-142"}}, "856": {"$insert": {"CARD_short_name": "mepR"}}, "3451": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-287"}}, "850": {"$update": {"ARO_description": "OXA-26 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1929": {"$update": {"dna_sequence": {"$update": {"accession": "AF201827.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-26"}}, "851": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4593": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}, "ARO_category": {"$update": {"40002": {"$update": {"category_aro_name": "Pyrazinamide resistant pncA", "category_aro_description": "pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide to pyrazinoic acid. Mutations arise within the pncA gene that caused the loss of pyrazinamidase activity is the major mechanism of antibiotic resistance."}}}}}, "$insert": {"CARD_short_name": "Mtub_pncA_PZA"}}, "3454": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-291"}}, "3455": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-292"}}, "5650": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8025": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SGM-7"}}, "3458": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-295"}}, "3459": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-297"}}, "858": {"$update": {"ARO_description": "IND-14 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1908": {"$update": {"dna_sequence": {"$update": {"accession": "HM367709.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-14"}}, "5083": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-774"}}, "3293": {"$insert": {"CARD_short_name": "tet(55)"}}, "4088": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-23 [Klebsiella pneumoniae] Accession: WP_111672911.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-23"}}, "2787": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4101": {"$update": {"dna_sequence": {"$update": {"accession": "AY905613.1"}}, "protein_sequence": {"$update": {"accession": "AAX99225.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-19"}}, "5350": {"$insert": {"CARD_short_name": "PDC-213"}}, "1058": {"$update": {"ARO_description": "VIM-27 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"2041": {"$update": {"dna_sequence": {"$update": {"accession": "HQ858608.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-27"}}, "1059": {"$update": {"ARO_description": "APH(9)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. flavopersicus.", "ARO_category": {"$update": {"36292": {"$update": {"category_aro_description": "Phosphorylation of spectinomycin on the hydroxyl group at position 9."}}}}}, "$insert": {"CARD_short_name": "APH(9)-Ib"}}, "3989": {"$update": {"ARO_description": "TEM-226 is a beta lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-226"}}, "5359": {"$insert": {"CARD_short_name": "PDC-22"}}, "5358": {"$insert": {"CARD_short_name": "PDC-21b"}}, "1696": {"$update": {"ARO_description": "Point mutation in Salmonella serovars resulting in fluoroquinolone resistance.", "model_name": "Salmonella serovars gyrB conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Sser_gyrB_FLO"}}, "1697": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-353"}}, "1695": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1707": {"$update": {"dna_sequence": {"$update": {"accession": "JF273491.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-5"}}, "1692": {"$insert": {"CARD_short_name": "tetM"}}, "1693": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1568": {"$update": {"dna_sequence": {"$update": {"accession": "DQ075245.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-317"}}, "1691": {"$update": {"ARO_description": "CMY-31 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1776": {"$update": {"dna_sequence": {"$update": {"accession": "EF622224.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-31"}}, "5657": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-164"}}, "1698": {"$update": {"ARO_description": "OCH-6 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi.", "model_sequences": {"$update": {"sequence": {"$update": {"1811": {"$update": {"dna_sequence": {"$update": {"accession": "AJ295344.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Brucella anthropi"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36233": {"$update": {"category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi."}}}}}, "$insert": {"CARD_short_name": "OCH-6"}}, "1699": {"$update": {"ARO_description": "Also known as vanXO, is a vanX variant found in the vanO gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"23": {"$update": {"dna_sequence": {"$update": {"accession": "KF478993.1"}}}}}}}}, "model_name": "vanX gene in vanO cluster", "ARO_name": "vanX gene in vanO cluster"}, "$insert": {"CARD_short_name": "vanX_in_vanO_cl"}}, "4310": {"$insert": {"CARD_short_name": "ADC-244"}}, "1279": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"995": {"$update": {"dna_sequence": {"$update": {"accession": "AF516719.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-104"}}, "618": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3290": {"$update": {"dna_sequence": {"$update": {"accession": "AB091338.1"}}}}}}}}, "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "emeA"}}, "619": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"918": {"$update": {"dna_sequence": {"$update": {"accession": "AY661885.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114r"}}, "4316": {"$insert": {"CARD_short_name": "ADC-250"}}, "4317": {"$insert": {"CARD_short_name": "ADC-251"}}, "1270": {"$update": {"ARO_description": "QnrS3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"5854": {"$update": {"dna_sequence": {"$update": {"accession": "EU077611.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrS3"}}, "1271": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"139": {"$update": {"dna_sequence": {"$update": {"accession": "AF031331.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iw"}}, "610": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1312": {"$update": {"dna_sequence": {"$update": {"accession": "JX121120.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-45"}}, "1794": {"$update": {"ARO_description": "tmrB is an ATP-binding tunicamycin resistance protein found in Bacillus subtilis."}, "$insert": {"CARD_short_name": "tmrB"}}, "3308": {"$insert": {"CARD_short_name": "Tet(47)"}}, "3333": {"$update": {"ARO_description": "A class C ADC beta-lactamase and cephalosporinase found in Acinetobacter baumannii."}, "$insert": {"CARD_short_name": "ADC-73"}}, "4816": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-3"}}, "1472": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1171": {"$update": {"dna_sequence": {"$update": {"accession": "KM087841.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-18"}}, "1473": {"$update": {"ARO_description": "CTX-M-44 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1903": {"$update": {"dna_sequence": {"$update": {"accession": "D37830.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-44"}}, "1470": {"$update": {"ARO_description": "QnrB26 is a plasmid-mediated quinolone resistance protein found in Proteus vulgaris.", "model_sequences": {"$update": {"sequence": {"$update": {"114": {"$update": {"dna_sequence": {"$update": {"accession": "HQ386846.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB26"}}, "1471": {"$insert": {"CARD_short_name": "adeI"}}, "1476": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5867": {"$update": {"dna_sequence": {"$update": {"accession": "JX050178.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-40"}}, "2747": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "AcrEF-TolC confers resistance to ciprofloxacin"}, "$insert": {"CARD_short_name": "AcrEF_TolC_CIP"}}, "1495": {"$update": {"model_sequences": {"$update": {"sequence": {"8163": {"dna_sequence": {"partial": "0", "sequence": "ATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCACCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGCCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACCCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTTACCGGCGTACTGGGTGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACGGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTACCGGATGAGGTCGCGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGTACCACGCGTCTTTACGCCAATACCAGCATCGGCCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAACAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTACACGTTTCGCCAGGCATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGCAAGGCATTGCCCTGGCGCAGTCTCGCTACTGGCGCGTAGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCACTGGCACCGCTGCCCGCAAGAGAAGTGAATCCTCCGGCGCCTCCGGTCAACGCGTCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCCAACCCAGCACGCGTTGAGGCGGCTTACCGTATTTTGAGCGCGCTGTAG", "fmax": "2618", "accession": "EU427302.2", "fmin": "1475", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter asburiae", "NCBI_taxonomy_id": "61645", "NCBI_taxonomy_cvterm_id": "36926"}, "protein_sequence": {"accession": "ABZ81086.1", "sequence": "MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVADNASLLRFYQNWQPQWKPGTTRLYANTSIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-4"}}, "1304": {"$update": {"ARO_description": "CTX-M-85 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"1336": {"$update": {"dna_sequence": {"$update": {"accession": "FJ214368.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-85"}}, "1305": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "OprM"}}, "1306": {"$update": {"ARO_description": "IND-5 is a beta-lactamase found in Chryseobacterium indologenes.", "model_sequences": {"$update": {"sequence": {"$update": {"1093": {"$update": {"dna_sequence": {"$update": {"accession": "AY504627.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-5"}}, "1307": {"$update": {"ARO_description": "OXY-1-6 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"982": {"$update": {"dna_sequence": {"$update": {"accession": "Y17715.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-1-6"}}, "1300": {"$insert": {"CARD_short_name": "MexF"}}, "1301": {"$update": {"ARO_description": "Cardiolipin synthetase (cls) is an inner membrane protein that is involved in membrane synthesis. Specific mutations in S. aureus can confer resistance to daptomycin."}, "$insert": {"CARD_short_name": "Saur_cls_DAP"}}, "1303": {"$update": {"ARO_description": "BEL-2 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1280": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666063.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BEL-2"}}, "2005": {"$update": {"ARO_description": "CTX-M-89 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1630": {"$update": {"dna_sequence": {"$update": {"accession": "FJ971899.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-89"}}, "3334": {"$update": {"ARO_description": "AAC(6')-Il is an aminoglycoside acetyltransferase encoded by plasmids and integrons in Enterobacter cloaecae and Klebsiella aerogenes.", "model_sequences": {"$update": {"sequence": {"8368": {"dna_sequence": {"partial": "0", "sequence": "ATGGATAGTTCGCCGCTCGTCAGGCCTGTTGAAACTACCGATTCGGCCAGTTGGCTAAGCATGCGCTGTGAGCTGTGGCCAGATGGCACATGTCAAGAGCACCAGTCAGAGATCGCAGAATTTCTGTCCGGAAAAGTCGCCCGGCCTGCTGCTGTCCTCATTGCTGTAGCACCCGACGGAGAAGCACTAGGGTTTGCCGAGCTTTCGATCCGCCCGTATGCGGAGGAGTGCTACTCCGGCAACGTTGCGTTCTTGGAGGGTTGGTACGTTGTGCCAAGTGCGCGGCGTCAGGGCGTAGGTGTAGCTCTGGTAAAAGCCGCCGAGCATTGGGCTCGTGGTCGCGGATGCACCGAATTCGCCTCCGACACTCAACTTACCAACAGCGCAAGCACCTCGGCGCACCTGGCGGCTGGATTCACGGAGGTTGCTCAAGTACGCTGCTTCCGGAAACCGTTGTGA", "fmax": "767", "accession": "U13880.2", "fmin": "308", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella aerogenes", "NCBI_taxonomy_id": "548", "NCBI_taxonomy_cvterm_id": "36770"}, "protein_sequence": {"accession": "AAA90937.1", "sequence": "MDSSPLVRPVETTDSASWLSMRCELWPDGTCQEHQSEIAEFLSGKVARPAAVLIAVAPDGEALGFAELSIRPYAEECYSGNVAFLEGWYVVPSARRQGVGVALVKAAEHWARGRGCTEFASDTQLTNSASTSAHLAAGFTEVAQVRCFRKPL"}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Il"}}, "1308": {"$update": {"ARO_description": "Also known as vanTE, is a vanT variant found in the vanE gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"180": {"$update": {"dna_sequence": {"$update": {"accession": "FJ872411.1"}}}}}}}}, "model_name": "vanT gene in vanE cluster", "ARO_name": "vanT gene in vanE cluster"}, "$insert": {"CARD_short_name": "vanT_in_vanE_cl"}}, "1309": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1853": {"$update": {"dna_sequence": {"$update": {"accession": "KF526117.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-20"}}, "5469": {"$insert": {"CARD_short_name": "PDC-34"}}, "498": {"$update": {"ARO_description": "QnrB17 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"388": {"$update": {"dna_sequence": {"$update": {"accession": "AM919398.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB17"}}, "4229": {"$insert": {"CARD_short_name": "ADC-160"}}, "5468": {"$insert": {"CARD_short_name": "PDC-339"}}, "494": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1971": {"$update": {"dna_sequence": {"$update": {"accession": "JX524191.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-14"}}, "495": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1547": {"$update": {"dna_sequence": {"$update": {"accession": "EF561644.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-28"}}, "496": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"792": {"$update": {"dna_sequence": {"$update": {"accession": "KC465199.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-16"}}, "497": {"$update": {"ARO_description": "OXA-79 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1693": {"$update": {"dna_sequence": {"$update": {"accession": "EU019534.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-79"}}, "490": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2034": {"$update": {"dna_sequence": {"$update": {"accession": "JN211012.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-188"}}, "491": {"$update": {"ARO_description": "PER-2 is a beta-lactamase found in Salmonella typhimurium.", "model_sequences": {"$update": {"sequence": {"$update": {"898": {"$update": {"dna_sequence": {"$update": {"accession": "X93314.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-2"}}, "492": {"$update": {"ARO_description": "catB is a chromosome-encoded variant of the cat gene found in Clostridium butyricum.", "model_sequences": {"$update": {"sequence": {"$update": {"174": {"$update": {"dna_sequence": {"$update": {"accession": "M93113.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Cbut_catB"}}, "493": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1328": {"$update": {"dna_sequence": {"$update": {"accession": "AF427130.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-84"}}, "24": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3451": {"$update": {"dna_sequence": {"$update": {"accession": "AY047358.1"}}}}}}}}}, "$insert": {"CARD_short_name": "fusB"}}, "25": {"$update": {"ARO_description": "CTX-M-121 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1085": {"$update": {"dna_sequence": {"$update": {"accession": "JN790862.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-121"}}, "26": {"$update": {"ARO_description": "VEB-3 is a beta-lactamase found in Enterobacter cloacae.", "model_sequences": {"$update": {"sequence": {"$update": {"1406": {"$update": {"dna_sequence": {"$update": {"accession": "AY536519.1"}}}}}}}}, "ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-3"}}, "27": {"$update": {"ARO_description": "lnuA is a plasmid-mediated nucleotidyltransferase found in Staphylococcus chromogenes."}, "$insert": {"CARD_short_name": "lnuA"}}, "20": {"$update": {"ARO_description": "CMY-1 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1034": {"$update": {"dna_sequence": {"$update": {"accession": "X92508.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-1"}}, "21": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1212": {"$update": {"dna_sequence": {"$update": {"accession": "KF203103.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-329"}}, "5580": {"$insert": {"CARD_short_name": "PDC-453"}}, "23": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1301": {"$update": {"dna_sequence": {"$update": {"accession": "AB871653.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-371"}}, "927": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1933": {"$update": {"dna_sequence": {"$update": {"accession": "KJ135344.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-381"}}, "28": {"$update": {"ARO_description": "OXA-45 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1463": {"$update": {"dna_sequence": {"$update": {"accession": "AJ519683.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-45"}}, "29": {"$update": {"ARO_category": {"$update": {"39999": {"$update": {"category_aro_description": "Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance."}}}}}, "$insert": {"CARD_short_name": "Ecol_folP_SLF"}}, "5588": {"$insert": {"CARD_short_name": "PDC-460"}}, "5589": {"$insert": {"CARD_short_name": "PDC-462"}}, "4311": {"$insert": {"CARD_short_name": "ADC-245"}}, "901": {"$update": {"ARO_description": "LCR-1 is a class D beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"775": {"$update": {"dna_sequence": {"$update": {"accession": "X56809.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LCR-1"}}, "3262": {"$update": {"ARO_description": "A dihydrofolate reductase and trimethoprim resistance gene isolated from canine Escherichia coli infection."}, "$insert": {"CARD_short_name": "dfrA29"}}, "5037": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-727"}}, "5034": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-722"}}, "5267": {"$insert": {"CARD_short_name": "PDC-130"}}, "4467": {"$insert": {"CARD_short_name": "CMH-5"}}, "5035": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-723"}}, "3939": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6302": {"$update": {"dna_sequence": {"$update": {"accession": "MF042206.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-153"}}, "3938": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6301": {"$update": {"dna_sequence": {"$update": {"accession": "HE819403.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-89"}}, "4415": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-29"}}, "5266": {"$insert": {"CARD_short_name": "PDC-13"}}, "3935": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6298": {"$update": {"dna_sequence": {"$update": {"accession": "KM985466.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-128"}}, "3934": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6297": {"$update": {"dna_sequence": {"$update": {"partial": "0", "accession": "KY780116.1", "strand": "-", "sequence": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCATGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGTGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-151"}}, "3937": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6300": {"$update": {"dna_sequence": {"$update": {"accession": "KM985465.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-127"}}, "3936": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6299": {"$update": {"dna_sequence": {"$update": {"accession": "KM985467.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-129"}}, "3931": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6294": {"$update": {"dna_sequence": {"$update": {"accession": "KM507172.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-121"}}, "3930": {"$update": {"ARO_description": "A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-216"}}, "3933": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6296": {"$update": {"dna_sequence": {"$update": {"accession": "KC007363.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-97"}}, "3932": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6295": {"$update": {"dna_sequence": {"$update": {"accession": "KY978224.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-152"}}, "1703": {"$update": {"model_sequences": {"$update": {"sequence": {"8153": {"dna_sequence": {"partial": "0", "sequence": "ATGATCACTGGTATCAATCACATCACCTTTTCCGTCAGGGACTTGAGCTCTTCAATCGAGTTCTATCGTGACTTGCTGGGAATGAGGCTGCACGTGACCTGGGAAGCAGGTGCTTATTTTACAGCGGGTGATACGTGGGTATGTCTGAGCGTCGGGGAACCTAAACCCGCCAACGACTACACGCATGTGGCATTCAGTGTTGGCGAAAGAGAGCTTGTTGAGCTGCACGCTAGGCTAAAAGAAGCCGGGGTTGAGGAGTGGAAGCAGAATACAAGTGAGGGTAACTCCGTGTATCTGCTTGATCCAAACGGCCATCGCATTGAGCTTCACTGCGGAACGTTGGCAACCCGCTTAGCTGAGTTGGAGAAGTCGCCCTATAAAAGGTTGGTCTGGTGCTGA", "fmax": "1135", "accession": "AB917040.2", "fmin": "736", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter soli", "NCBI_taxonomy_id": "487316", "NCBI_taxonomy_cvterm_id": "39070"}, "protein_sequence": {"accession": "BAO79518.1", "sequence": "MITGINHITFSVRDLSSSIEFYRDLLGMRLHVTWEAGAYFTAGDTWVCLSVGEPKPANDYTHVAFSVGERELVELHARLKEAGVEEWKQNTSEGNSVYLLDPNGHRIELHCGTLATRLAELEKSPYKRLVWC"}}}}}}, "$insert": {"CARD_short_name": "FosK"}}, "5420": {"$insert": {"CARD_short_name": "PDC-288"}}, "5263": {"$insert": {"CARD_short_name": "PDC-127"}}, "5262": {"$insert": {"CARD_short_name": "PDC-126"}}, "4138": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-47"}}, "4139": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-48"}}, "5261": {"$insert": {"CARD_short_name": "PDC-125"}}, "4434": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6809": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-50"}}, "4130": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-39"}}, "4131": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-40"}}, "4132": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-41"}}, "4133": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-42"}}, "4134": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-43"}}, "4135": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-44"}}, "4136": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-45"}}, "4137": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-46"}}, "5692": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-41"}}, "5693": {"$update": {"ARO_description": "From Lahey's list of beta-lactamases, no additional information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-44"}}, "5690": {"$insert": {"CARD_short_name": "VHW-1"}}, "3842": {"$insert": {"CARD_short_name": "AAC(6')-Ib-cr5"}}, "5696": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-47"}}, "5697": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8072": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-48"}}, "3847": {"$insert": {"CARD_short_name": "lsa(D)"}}, "3846": {"$insert": {"CARD_short_name": "AAC(6')-Ib-cr9"}}, "3849": {"$insert": {"CARD_short_name": "PDC-70"}}, "3848": {"$update": {"ARO_description": "PDC-68 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-68"}}, "5698": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-49"}}, "5699": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-50"}}, "5302": {"$insert": {"CARD_short_name": "PDC-163"}}, "4430": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-46"}}, "5303": {"$insert": {"CARD_short_name": "PDC-164"}}, "4433": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-49"}}, "3916": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6277": {"$update": {"dna_sequence": {"$update": {"accession": "NG_048793.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-122"}}, "5304": {"$insert": {"CARD_short_name": "PDC-165"}}, "4432": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-48"}}, "5305": {"$insert": {"CARD_short_name": "PDC-166"}}, "3267": {"$update": {"ARO_description": "Mutations in murG which confer resistance to vancomycin in Clostridioides difficile."}, "$insert": {"CARD_short_name": "Cdif_murG_VAN"}}, "5306": {"$insert": {"CARD_short_name": "PDC-167"}}, "5268": {"$insert": {"CARD_short_name": "PDC-131"}}, "301": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1702": {"$update": {"dna_sequence": {"$update": {"accession": "JX514369.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-95"}}, "4044": {"$update": {"ARO_description": "PDC-429 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-429"}}, "4045": {"$update": {"ARO_description": "PDC-449 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-449"}}, "4046": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6412": {"$update": {"dna_sequence": {"$update": {"accession": "NG_052174.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-540"}}, "4047": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6413": {"$update": {"dna_sequence": {"$update": {"accession": "NG_062354.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-779"}}, "4040": {"$update": {"ARO_description": "PDC-393 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-393"}}, "4041": {"$update": {"ARO_description": "PDC-119 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-119"}}, "4042": {"$update": {"ARO_description": "PDC-313 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-313"}}, "4043": {"$update": {"ARO_description": "PDC-257 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-257"}}, "4315": {"$insert": {"CARD_short_name": "ADC-249"}}, "3910": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6271": {"$update": {"dna_sequence": {"$update": {"accession": "NG_055270.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-154"}}, "4048": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6414": {"$update": {"dna_sequence": {"$update": {"accession": "MN339504.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-838"}}, "4049": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6415": {"$update": {"dna_sequence": {"$update": {"accession": "NG_052064.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-539"}}, "946": {"$update": {"ARO_description": "QnrB48 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"177": {"$update": {"dna_sequence": {"$update": {"accession": "JQ762640.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB48"}}, "3786": {"$insert": {"CARD_short_name": "cmlA9"}}, "7": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1703": {"$update": {"dna_sequence": {"$update": {"accession": "JX017365.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-130"}}, "3982": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-37"}}, "3665": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-24"}}, "3664": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-23"}}, "3666": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-25"}}, "3661": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-20"}}, "3660": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase and NDM-1 variant.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-19"}}, "3663": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase and NDM-1 variant.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-22"}}, "3662": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase and NDM-1 variant.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-21"}}, "2281": {"$update": {"model_sequences": {"$update": {"sequence": {"8174": {"dna_sequence": {"partial": "0", "sequence": "TTGCTCTGGTGGGACGACATTTCGATGAGCCTGATTGATGATGAAATACCTTCTTCGCAACCGCAAGTGTCAGGTAGGCATTTCGGCTGGTTGAAACAATATCAGCATTTTCTGTTTCCAATCGCAGGCATCGCCATTGCGTTATTGGCTATTTATGTTCTGGAAAATCTTCTCAGGCACACCTCCCGCACCGAAACGCTTGCAGCCCTTCACAATATTTCATGGACGACGCTCGCACTGGCCGTCTTTTTCACAGCATTAAGCTATGCCGCAGTGGCGCTTTATGATGTCGTGGCGGTGGACACCATAGCGCCCAACCAGATACCGCGCCGCATCGCGGCGGTGGCGGGTGCTGCGGGCTATGCGATTTCCAACGCGCTCGGCTTCTCGCTCCTGACCGGCGGGGCGCTGCGTTATCGCATTTATGCCGCAGAAGGCATAAGCCTGGCCGATATCGGCAAGATCGTCGGCACCTCATGGTTCGCCATCTGGTTCGCCCTCATCATCATGGTGGGCGCAGCCCTGCTGATCGATCCGCAGGACGTGCCTTTTCTTTCCGCCATCGATATACGGATTGATATTGTCGCAGGCATTCTCATCCTTGGCGGCATTGGCTGGCTGATCTACTGGCTTTCGCATGGCGAACGCAATGTCAGCATCGGTTCGTTCAGCCTGCGCCTGCCCAATTCAAAAGGCGCGCTCACGCAGATTTTTGCGGGCGTGGTGGATGTGGGCGCTGCCGCGGCCACGCTCTATGTGCTGTTGCCGGAAGGGGCTGTGCCAAGCTTCGCCGTCTTTGCGCTCGTTTATGTCATCGCCATCGTGCTTGGCATTGCAAGCCACGCGCCAGGCGGCCTCGGCGCTTTTGAGGCAACAATCATCGCAGGGCTTGGCCTCGGTGGAAAACCCGATGCAATTGCGGGCCTGCTGGCCTATCGCCTCATTTACACGGTTCTTCCCCTCGTGGTTGCCACCGCCGGAATCCTCATCTGGGAGGTCATGCGCCGCCGCCATATGCTCGACAAGCAGGCCCGATTCGCCAAGCGGCTGGTGGAGCCGCTGGTTCCGGGGCTTTCAGCCAGCATCATCTTTCTCGGTGGCATCATCCTGCTTATCTCAGGCGCCACGCCCGATATGCGCTATCGTGTGAAGTTGCTGTCCGACATCGTGCCGGAATTTCTTGTGGAGATGTCGCATCTGGCGGCAAGCCTCGTCGGCGTTGCTCTTCTCATCGTCGCGCGCGGCCTTTCCAAACGGCTGGAGCGCGCCTGGGTGGCCGCGATGGTGCTTCTTCTTTGCGGCGCGGTGTTTTCGATCGCAAAAGGACTGGACTGGGAAGAGGCAAGCATTTTGTGCCTTTTTGCCCTTTCACTCTGGGGCTTTCGCGATTCCTTCTACCGTCGTCCGATTGCCGGCCCGTTTGAACTGAGCTGGAACTGGATCGCAACCGTTGGAACCACGGTTCTCGTGTCCACCTGGCTTGGTTTTTTCGTCTACCGCCATATCGAATATTCAAGCGATCTCTGGTGGGATTTCGCGTGGAACGGCAACGCCCCGCGTTTCCTGCGCGCCACCGTTCTGGTTTTCGCAGTCGTGGCGGCAGTCGGCCTTCATTCGATCATCAACCGGCATGGCCAGCGCAGGCGCAAGGTTGATCATTCCATCCCCGATGCCGTGCCCGCACTCGTCGCCCGGTGCCCGCATACAGATGCAGCCCTTGCCATGCTGGGCGACAAGCAATTTCTGCTGGCGCCCGACGACAGCGCGTTCATCATGTATGCGCAGTCGGGCGGCAGCCTGATCGCGCTTGGCGAGCCTATCGGCGATGCCGAAGCGGGCAAGGAACTTGCCTGGTCTTTCCATTCGCTTGCCGACCGTCTGGCGCTGCGCACTGTCTTCTATGGTGTCGGCCCGCAAAGCCTGCCGCTTTTCCTCGATATGGGCCTGATTGCGCTCAAGCTGGGTGAAGTCGCACGCGTTGACCTGACAGATTTTTCGCTGGAAGGCCCGCGCCGCCAGCCCTTCCGTTATGCCGACCGCAAGGTGGACAAGGATGGGCTGACCTTCGAGATTATCCCTGCTGCGGACGTGCCGCCGCTGATCCCGCGCCTGCGCGCAATTTCCGACGCTTGGCTCGACCATAAATCAGGCAGCGAAAAGGGTTTTTCGCTTGGCTATTTCAACGATGAGTATTTAAAGCGTTTCGATATTGCCGTGCTGAAGAAAGACGGCGAAATCGTTGCTTTCGCCAATATATGGCGCGGTGCCGACAAGTATGAGATCACGGTCGACCTGATGCGCTACATGCCCAATGTGCACAAGCTCCTGATGGATGCGCTGTTCGCCAAGCTGCTGACCTTTTCCAAGCAAGAAGGCTACAAATGGTTCAACCTTGGCGCGGCCCCGCTTTCCGGCCTTAGCGGCAGCAGGCTTGCCTCGCGCTGGAACCGTTTCGGCTCGTTCATCTATCGCCGTGGGGCCGATCTTTATCACTTCGACGGGCTCAAAGCCTTCAAGGAAAAATTCGATCCCGTCTGGACCCCGCATTATATGGTTTGCCCCGGCGGGCTTGAAACGCCGCGCGCCCTTCTTGATGCCACAACACTGATTAACGGCAGCCCTTTGGAGTTCATTCGCAAATGA", "fmax": "570923", "accession": "AE014292.2", "fmin": "568280", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Brucella suis 1330", "NCBI_taxonomy_id": "204722", "NCBI_taxonomy_cvterm_id": "36780"}, "protein_sequence": {"accession": "AAN33774.1", "sequence": "MLWWDDISMSLIDDEIPSSQPQVSGRHFGWLKQYQHFLFPIAGIAIALLAIYVLENLLRHTSRTETLAALHNISWTTLALAVFFTALSYAAVALYDVVAVDTIAPNQIPRRIAAVAGAAGYAISNALGFSLLTGGALRYRIYAAEGISLADIGKIVGTSWFAIWFALIIMVGAALLIDPQDVPFLSAIDIRIDIVAGILILGGIGWLIYWLSHGERNVSIGSFSLRLPNSKGALTQIFAGVVDVGAAAATLYVLLPEGAVPSFAVFALVYVIAIVLGIASHAPGGLGAFEATIIAGLGLGGKPDAIAGLLAYRLIYTVLPLVVATAGILIWEVMRRRHMLDKQARFAKRLVEPLVPGLSASIIFLGGIILLISGATPDMRYRVKLLSDIVPEFLVEMSHLAASLVGVALLIVARGLSKRLERAWVAAMVLLLCGAVFSIAKGLDWEEASILCLFALSLWGFRDSFYRRPIAGPFELSWNWIATVGTTVLVSTWLGFFVYRHIEYSSDLWWDFAWNGNAPRFLRATVLVFAVVAAVGLHSIINRHGQRRRKVDHSIPDAVPALVARCPHTDAALAMLGDKQFLLAPDDSAFIMYAQSGGSLIALGEPIGDAEAGKELAWSFHSLADRLALRTVFYGVGPQSLPLFLDMGLIALKLGEVARVDLTDFSLEGPRRQPFRYADRKVDKDGLTFEIIPAADVPPLIPRLRAISDAWLDHKSGSEKGFSLGYFNDEYLKRFDIAVLKKDGEIVAFANIWRGADKYEITVDLMRYMPNVHKLLMDALFAKLLTFSKQEGYKWFNLGAAPLSGLSGSRLASRWNRFGSFIYRRGADLYHFDGLKAFKEKFDPVWTPHYMVCPGGLETPRALLDATTLINGSPLEFIRK"}}}}}}, "$insert": {"CARD_short_name": "Bsui_mprF"}}, "2282": {"$insert": {"CARD_short_name": "Cper_mprF"}}, "2283": {"$insert": {"CARD_short_name": "Saga_mprF"}}, "2284": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3548": {"$update": {"dna_sequence": {"$update": {"accession": "CP009072.1"}}, "protein_sequence": {"$update": {"accession": "AIL15701.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ecol_murA_FOF"}}, "2285": {"$insert": {"CARD_short_name": "Saur_murA_FOF"}}, "2286": {"$insert": {"CARD_short_name": "Bbur_mur_FOF"}}, "2287": {"$update": {"model_name": "Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid"}, "$insert": {"CARD_short_name": "Msme_ndh_INH"}}, "4549": {"$insert": {"CARD_short_name": "CTX-M-220"}}, "4548": {"$insert": {"CARD_short_name": "CTX-M-219"}}, "5152": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-855"}}, "4946": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-620"}}, "4541": {"$insert": {"CARD_short_name": "CTX-M-212"}}, "4540": {"$insert": {"CARD_short_name": "CTX-M-211"}}, "4543": {"$insert": {"CARD_short_name": "CTX-M-214"}}, "4542": {"$insert": {"CARD_short_name": "CTX-M-213"}}, "4545": {"$insert": {"CARD_short_name": "CTX-M-216"}}, "4544": {"$insert": {"CARD_short_name": "CTX-M-215"}}, "4547": {"$insert": {"CARD_short_name": "CTX-M-218"}}, "4539": {"$insert": {"CARD_short_name": "CTX-M-210"}}, "4828": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-396"}}, "5655": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-146"}}, "2762": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "MexMN-OprM"}}, "690": {"$update": {"ARO_description": "OXA-347 is a beta-lactamase found in Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"4583": {"$update": {"dna_sequence": {"$update": {"accession": "JN086160.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-347"}}, "2056": {"$update": {"ARO_description": "Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.", "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mdtO"}}, "5583": {"$insert": {"CARD_short_name": "PDC-456"}}, "4826": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-307"}}, "2378": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5882": {"$update": {"dna_sequence": {"$update": {"accession": "HG738867.1"}}, "protein_sequence": {"$update": {"accession": "CDJ73082.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ecol_cyaA_FOF"}}, "2379": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4616": {"$update": {"dna_sequence": {"$update": {"accession": "HG738867.1"}}, "protein_sequence": {"$update": {"accession": "CDJ73082.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ecol_cyaA_FOF"}}, "4535": {"$insert": {"CARD_short_name": "CTX-M-206"}}, "2374": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3668": {"$update": {"dna_sequence": {"$update": {"accession": "HG738867.1"}}, "protein_sequence": {"$update": {"accession": "CDJ73205.1"}}}}}}}}, "ARO_name": "Escherichia coli uhpA with mutation conferring resistance to fosfomycin"}, "$insert": {"CARD_short_name": "Ecol_uhpA_FOF"}}, "2375": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "Rm3"}, "$insert": {"CARD_short_name": "Rm3"}}, "2376": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3671": {"$update": {"dna_sequence": {"$update": {"accession": "HG738867.1"}}, "protein_sequence": {"$update": {"accession": "CDJ73205.1"}}}}}}}}, "ARO_name": "Escherichia coli uhpA with mutation conferring resistance to fosfomycin"}, "$insert": {"CARD_short_name": "Ecol_uhpA_FOF"}}, "2377": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3675": {"$update": {"dna_sequence": {"$update": {"accession": "HG738867.1"}}, "protein_sequence": {"$update": {"accession": "CDJ72759.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ecol_PtsI_FOF"}}, "2370": {"$insert": {"CARD_short_name": "ADC-81"}}, "2371": {"$insert": {"CARD_short_name": "ADC-82"}}, "2372": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4617": {"$update": {"dna_sequence": {"$update": {"accession": "HG738867.1"}}, "protein_sequence": {"$update": {"accession": "CDJ72593.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ecol_GlpT_FOF"}}, "2373": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3667": {"$update": {"dna_sequence": {"$update": {"accession": "HG738867.1"}}, "protein_sequence": {"$update": {"accession": "CDJ73208.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ecol_UhpT_FOF"}}, "3593": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-2"}}, "3592": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-1"}}, "3591": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FPH-1"}}, "3590": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FONA-6"}}, "4318": {"$insert": {"CARD_short_name": "ADC-252"}}, "3596": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-10"}}, "3595": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FTU-1"}}, "3594": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-3"}}, "5036": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-726"}}, "4822": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114w"}}, "3599": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-13"}}, "3598": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-12"}}, "5032": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-720"}}, "5033": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-721"}}, "5030": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-718"}}, "5031": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-719"}}, "1876": {"$update": {"ARO_description": "LEN-7 is a beta-lactamase found in Klebsiella pneumoniae.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-7"}}, "1877": {"$update": {"ARO_description": "CMY-12 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1421": {"$update": {"dna_sequence": {"$update": {"accession": "Y16785.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-12"}}, "1874": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"802": {"$update": {"dna_sequence": {"$update": {"accession": "HQ425494.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-196"}}, "1875": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1182": {"$update": {"dna_sequence": {"$update": {"accession": "KM087859.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-11"}}, "1872": {"$update": {"ARO_description": "Also known as vanXYL, is a vanXY variant found in the vanL gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"168": {"$update": {"dna_sequence": {"$update": {"accession": "EU250284.1"}}}}}}}}, "model_name": "vanXY gene in vanL cluster", "ARO_name": "vanXY gene in vanL cluster"}, "$insert": {"CARD_short_name": "vanXY_in_vanL"}}, "1873": {"$insert": {"CARD_short_name": "linG"}}, "1870": {"$update": {"ARO_description": "OXA-66 is a beta-lactamase found in A. baumannii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-66"}}, "1871": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1302": {"$update": {"dna_sequence": {"$update": {"accession": "KJ135346.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-389"}}, "5158": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-861"}}, "1083": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2008": {"$update": {"dna_sequence": {"$update": {"accession": "KF203097.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-323"}}, "4533": {"$insert": {"CARD_short_name": "CTX-M-204"}}, "4439": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-55"}}, "4438": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-54"}}, "1878": {"$update": {"ARO_description": "SRT-2, isolated from Serratia marcescens, is a chromosomal beta-lactamase that confers resistance to cefotaxime.", "model_sequences": {"$update": {"sequence": {"8219": {"dna_sequence": {"partial": "0", "sequence": "ATGACGAAAATGAACCGCCTGGCGGCCGCGCTGATCGCCGCACTGATCTTGCCGACCGCGCAGGCCGCGCAGCAGCAGGATATCGACGCCGTTATTCAGCCGCTGATGAAAAAATATGGCGTACCGGGCATGGCGATCGCCGTGTCGGTCGACGGCAAACAGCAGATTTACCCGTATGGCGTCGCCTCGAAGCAGACCGGCAAACCGATCACCGAGGAGACGCTGTTCGAAGTGGGCTCGCTGAGCAAAACCTTTACCGCGACGCTGGCGGTCTATGCGCAGCAGCAGGGCAAGCTGTCGTTCAACGATCCGGCCAGCCGCTATCTGCCCGAGCTGCGCGGCAGCGCCTTCGACGGCGTCAGCCTGCTGAATCTGGCGACGCATACCTCCGGCCTGCCGCTGTTCGTGCCGGACGACGTCACTAACGACGCCCAGCTGATGGCCTACTACCGGGCCTGGCAGCCGAAACACCCGGCGGGCAGCTACCGTGTCTATTCCAACCTCGGCATCGGCATGCTGGGCATGATCGCCGCCAAGAGCCTCGACCAGCCGTTTATCCAGGCGATGGAACAGGGGATGCTGCCGGCGCTGGGCATGAGCCACACCTACGTTCAGGTGCCGGCGGCGCAGATGGCTAACTATGCGCAGGGTTACAGCAAGGACGATAAGCCGGTGCGGGTCAACCCCGGCCCGCTGGATGCCGAGTCTTACGGCATCAAGTCCAACGCTCGCGATCTGATTCGCTATCTGGACGCCAACCTGCAGCAGGTGAAGGTGGCGCAGCCGTGGCGCGACGCGCTGGCCGCGACGCACGTCGGGTATTACAAGGCGGGCGCGTTCACGCAGGATCTGATGTGGGAGAACTACCCGTATCCGGTGAAACTGTCGCGTTTGATTGAAGGCAACAACGCCGGGATGATCATGAACGGCACGCCGGCCACCGCCATCACGCCGCCGCAGCCGGAATTGCGCGCCGGCTGGTATAACAAAACCGGCTCCACCGGCGGCTTCTCCACCTACGCGGTATTTATCCCGGCGAAAAATATCGCCGTGGTGATGCTGGCCAACAAGTGGTTCCCGAACGACGATCGCGTCGAGGCGGCTTACCACATCGTCCAGGCGCTGGAGAAGCGCTGA", "fmax": "1137", "accession": "AY524276.3", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Serratia marcescens", "NCBI_taxonomy_id": "615", "NCBI_taxonomy_cvterm_id": "36783"}, "protein_sequence": {"accession": "AAS07017.3", "sequence": "MTKMNRLAAALIAALILPTAQAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEETLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTSGLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKSNARDLIRYLDANLQQVKVAQPWRDALAATHVGYYKAGAFTQDLMWENYPYPVKLSRLIEGNNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLANKWFPNDDRVEAAYHIVQALEKR"}}}}}}, "$insert": {"CARD_short_name": "SRT-2"}}, "1879": {"$update": {"ARO_description": "AAC(3)-IIIa is a chromosomal-encoded aminoglycoside acetyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"6": {"$update": {"dna_sequence": {"$update": {"accession": "X55652.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-IIIa"}}, "977": {"$update": {"ARO_description": "OXA-112 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1752": {"$update": {"dna_sequence": {"$update": {"accession": "EF650038.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-112"}}, "976": {"$update": {"ARO_description": "CTX-M-61 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"2044": {"$update": {"dna_sequence": {"$update": {"accession": "EF219142.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-61"}}, "975": {"$update": {"ARO_description": "QnrB1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae.", "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB1"}}, "974": {"$update": {"ARO_description": "lmrC is an ABC-F subfamily protein that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD."}, "$insert": {"CARD_short_name": "lmrC"}}, "973": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-378"}}, "972": {"$update": {"ARO_description": "CMY-23 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1115": {"$update": {"dna_sequence": {"$update": {"accession": "DQ463751.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-23"}}, "4943": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-617"}}, "970": {"$update": {"ARO_description": "OKP-B-18 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1201": {"$update": {"dna_sequence": {"$update": {"accession": "AM850920.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-18"}}, "5581": {"$insert": {"CARD_short_name": "PDC-454"}}, "1080": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1712": {"$update": {"dna_sequence": {"$update": {"accession": "JX121125.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-158"}}, "4949": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-623"}}, "4948": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-622"}}, "979": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1004": {"$update": {"dna_sequence": {"$update": {"accession": "AY092401.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-96"}}, "978": {"$update": {"ARO_description": "OXA-134 is a beta-lactamase found in A. lwoffii.", "model_sequences": {"$update": {"sequence": {"$update": {"1922": {"$update": {"dna_sequence": {"$update": {"accession": "HQ122933.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-134"}}, "182": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "arlS"}}, "183": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"596": {"$update": {"dna_sequence": {"$update": {"accession": "HM440348.1"}}}}}}}}}, "$insert": {"CARD_short_name": "adeS"}}, "180": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1258": {"$update": {"dna_sequence": {"$update": {"accession": "KM087849.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-19"}}, "181": {"$update": {"ARO_description": "GES-14 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1984": {"$update": {"dna_sequence": {"$update": {"accession": "GU207844.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-14"}}, "186": {"$update": {"ARO_description": "OXA-12 is a beta-lactamase found in Aeromonas jandaei.", "model_sequences": {"$update": {"sequence": {"$update": {"1123": {"$update": {"dna_sequence": {"$update": {"accession": "U10251.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-12"}}, "187": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"808": {"$update": {"dna_sequence": {"$update": {"accession": "KF297577.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-348"}}, "184": {"$update": {"ARO_description": "OCH-1 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi.", "model_sequences": {"$update": {"sequence": {"$update": {"1426": {"$update": {"dna_sequence": {"$update": {"accession": "AJ401618.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Brucella anthropi"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36233": {"$update": {"category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi."}}}}}, "$insert": {"CARD_short_name": "OCH-1"}}, "185": {"$update": {"ARO_description": "OXA-232 is a beta-lactamase found in Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"1129": {"$update": {"dna_sequence": {"$update": {"accession": "JX423831.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-232"}}, "2110": {"$update": {"ARO_description": "CARB-20 is a beta-lactamase found worldwide in Vibrio parahaemolyticus.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-89"}}, "189": {"$update": {"ARO_description": "CTX-M-19 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1009": {"$update": {"dna_sequence": {"$update": {"accession": "AF325134.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-19"}}, "2114": {"$update": {"ARO_description": "APH(3')-IIa is a transposon-encoded aminoglycoside phosphotransferase in E. coli.", "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-IIa"}}, "2115": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-4"}}, "2116": {"$update": {"ARO_description": "Point mutations in the helix 34 region of 16S rRNA of Pasteurella multocida can confer resistance to spectinomycin."}, "$insert": {"CARD_short_name": "Pmul_16S_SPT"}}, "1559": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mtrA"}}, "5248": {"$insert": {"CARD_short_name": "PDC-110"}}, "4820": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114u"}}, "4089": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-25 [Klebsiella pneumoniae] Accession: WP_065419571.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-25"}}, "1919": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1873": {"$update": {"dna_sequence": {"$update": {"accession": "AF293345.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-27"}}, "1918": {"$update": {"ARO_description": "spd is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in S. aureus.", "model_sequences": {"$update": {"sequence": {"$update": {"758": {"$update": {"dna_sequence": {"$update": {"accession": "KC895984.1"}}}}}}}}, "ARO_category": {"$update": {"36367": {"$update": {"category_aro_description": "Nucleotidylylation of spectinomycin at the hydroxyl group at position 9."}}}}}, "$insert": {"CARD_short_name": "spd"}}, "5108": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-804"}}, "602": {"$update": {"ARO_description": "VIM-16 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1251": {"$update": {"dna_sequence": {"$update": {"accession": "EU419746.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-598"}}, "3289": {"$insert": {"CARD_short_name": "tet(52)"}}, "3288": {"$insert": {"CARD_short_name": "tet(51)"}}, "3287": {"$insert": {"CARD_short_name": "tet(50)"}}, "3286": {"$update": {"ARO_category": {"$insert": {"37250": {"category_aro_name": "triclosan", "category_aro_cvterm_id": "37250", "category_aro_accession": "3000870", "category_aro_class_name": "Antibiotic", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI)."}, "45598": {"category_aro_name": "chlorhexidine", "category_aro_cvterm_id": "45598", "category_aro_accession": "3007039", "category_aro_class_name": "Antibiotic", "category_aro_description": "Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate)."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}, "40514": {"category_aro_name": "benzalkonium chloride", "category_aro_cvterm_id": "40514", "category_aro_accession": "3003823", "category_aro_class_name": "Antibiotic", "category_aro_description": "Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent."}}}}, "$insert": {"CARD_short_name": "Kpne_KpnF"}}, "5100": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-795"}}, "5101": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-796"}}, "3283": {"$update": {"ARO_description": "KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.", "ARO_category": {"$insert": {"37250": {"category_aro_name": "triclosan", "category_aro_cvterm_id": "37250", "category_aro_accession": "3000870", "category_aro_class_name": "Antibiotic", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI)."}, "45598": {"category_aro_name": "chlorhexidine", "category_aro_cvterm_id": "45598", "category_aro_accession": "3007039", "category_aro_class_name": "Antibiotic", "category_aro_description": "Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate)."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}, "40514": {"category_aro_name": "benzalkonium chloride", "category_aro_cvterm_id": "40514", "category_aro_accession": "3003823", "category_aro_class_name": "Antibiotic", "category_aro_description": "Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent."}}}}, "$insert": {"CARD_short_name": "Kpne_KpnE"}}, "1914": {"$update": {"ARO_description": "BEL-3 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1359": {"$update": {"dna_sequence": {"$update": {"accession": "GQ202694.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BEL-3"}}, "3281": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40514": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"45598": {"category_aro_name": "chlorhexidine", "category_aro_cvterm_id": "45598", "category_aro_accession": "3007039", "category_aro_class_name": "Antibiotic", "category_aro_description": "Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate)."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Abau_AbuO"}}, "3280": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "Abau_AmvA"}}, "869": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-284"}}, "3448": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-215"}}, "860": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6246": {"$update": {"dna_sequence": {"$update": {"accession": "X98047.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-42"}}, "863": {"$update": {"ARO_description": "PER-7 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1309": {"$update": {"dna_sequence": {"$update": {"accession": "HQ713678.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-281"}}, "3441": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-275"}}, "3440": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-273"}}, "867": {"$update": {"ARO_description": "OXA-175 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"801": {"$update": {"dna_sequence": {"$update": {"accession": "HM113561.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-84"}}, "2027": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1037": {"$update": {"dna_sequence": {"$update": {"accession": "JQ733579.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-84"}}, "2752": {"$update": {"ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "ANT(3'')-IIa"}}, "2753": {"$update": {"model_sequences": {"$update": {"sequence": {"8286": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAATACATTTATGGATATCATTGGGTCTTTTGCTGCTGACAAACATCGTTCTTGCAGAAGAACCGCTACCCGAACTGGAAGTTAAAAAAATCGATGAGGGTGTTTATCTGCATACGTCCTATGAAAATTATCCAAGCTGGGGCTTGGTTGCATCCCACGGTTTGGTTTTTGTGGATGGTAAAGACGCTTACATTATTGATACACCCGCTACTGTTAAAGACACAGAAGTGTTAGTGCAATGGATTAACGATCAAGGCTTCAAACCCAAGGCCAGCATTTCTACGCACTTTCACGATGACAGCACCATCGGCATTGCCTACTTAAATTCCAAATCCATTCCGACCTACGCATCAGAACAAACTAATGAATTGCTTAATAAAGAAGTCGCTGCACAGGCAACGCATTCGTTTAAGAAAAATCCTTATTGGCTGTTAAAAAATAAAATCGAAGCTTTTTATCCGGGCGCTGGCCACACGCCTGACAATTTAGTGGTGTGGTTGCCGAAGCAGAAAATTCTATTCGGTGGCTGTTTTGTAAAACCCGAAGGGCTGGGAAATTTAAGCCATGCGGTAGTTTCTGAATGGCCTGCTTCTGCAGAAAAACTTATCAATCGCTATAGCGACGCAAAAATCGTAGTACCGGGTCATGGAACAATGGGCGATGCATCGCTGCTGGAAAAAACCAAACAGCGTGCGCTTGAGGCGGTTGCAAAGAAGAAATAA", "fmax": "2757", "accession": "KU961660.2", "fmin": "2031", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AMY61250.1", "sequence": "MKIHLWISLGLLLLTNIVLAEEPLPELEVKKIDEGVYLHTSYENYPSWGLVASHGLVFVDGKDAYIIDTPATVKDTEVLVQWINDQGFKPKASISTHFHDDSTIGIAYLNSKSIPTYASEQTNELLNKEVAAQATHSFKKNPYWLLKNKIEAFYPGAGHTPDNLVVWLPKQKILFGGCFVKPEGLGNLSHAVVSEWPASAEKLINRYSDAKIVVPGHGTMGDASLLEKTKQRALEAVAKKK"}}}}}, "model_name": "HMB-1"}, "$insert": {"CARD_short_name": "HMB-1"}}, "2022": {"$update": {"ARO_description": "CTX-M-104 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1104": {"$update": {"dna_sequence": {"$update": {"accession": "HQ833652.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-104"}}, "2023": {"$update": {"ARO_description": "OXA-132 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1753": {"$update": {"dna_sequence": {"$update": {"accession": "EU547447.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-132"}}, "3144": {"$update": {"model_name": "MCR-8.1"}, "$insert": {"CARD_short_name": "MCR-8.1"}}, "2117": {"$update": {"ARO_description": "AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii."}, "$insert": {"CARD_short_name": "AAC(6')-Ib7"}}, "1243": {"$insert": {"CARD_short_name": "mphA"}}, "2029": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1321": {"$update": {"dna_sequence": {"$update": {"accession": "AY327539.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-33"}}, "886": {"$update": {"ARO_description": "IND-10 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1672": {"$update": {"dna_sequence": {"$update": {"accession": "GU206353.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-10"}}, "885": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1161": {"$update": {"dna_sequence": {"$update": {"accession": "AF332513.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-63"}}, "884": {"$update": {"ARO_description": "CTX-M-99 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1108": {"$update": {"dna_sequence": {"$update": {"accession": "HM803271.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-99"}}, "4217": {"$insert": {"CARD_short_name": "ADC-147"}}, "889": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1509": {"$update": {"dna_sequence": {"$update": {"accession": "JX440349.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-74"}}, "888": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"197": {"$update": {"dna_sequence": {"$update": {"accession": "AF462611.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-925"}}, "5217": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-927"}}, "5214": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-923"}}, "5215": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-924"}}, "5212": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-921"}}, "5213": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-922"}}, "5210": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7585": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-919"}}, "5211": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-920"}}, "4014": {"$update": {"ARO_description": "PDC-258 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-258"}}, "5245": {"$insert": {"CARD_short_name": "PDC-107"}}, "5218": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-928"}}, "5219": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-929"}}, "3970": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 21-DEC-2017.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-200"}}, "356": {"$insert": {"CARD_short_name": "ErmU"}}, "354": {"$update": {"ARO_description": "QnrB24 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"756": {"$update": {"dna_sequence": {"$update": {"accession": "HM192542.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB24"}}, "5549": {"$insert": {"CARD_short_name": "PDC-42"}}, "3988": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-213"}}, "775": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"863": {"$update": {"dna_sequence": {"$update": {"accession": "KM087836.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-113"}}, "774": {"$update": {"ARO_description": "tet37 is a chromosome-encoded oxidoreductase isolated from an uncultured bacterium that confers resistance to tetracycline.", "model_sequences": {"$update": {"sequence": {"$update": {"24": {"$update": {"dna_sequence": {"$update": {"accession": "AF540889.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet37"}}, "776": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"79": {"$update": {"dna_sequence": {"$update": {"accession": "M37699.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tetX"}}, "771": {"$update": {"ARO_description": "CMY-24 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1195": {"$update": {"dna_sequence": {"$update": {"accession": "EF415650.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-24"}}, "770": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1715": {"$update": {"dna_sequence": {"$update": {"accession": "AY223863.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-57"}}, "773": {"$update": {"ARO_description": "OCH-4 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi.", "model_sequences": {"$update": {"sequence": {"$update": {"1659": {"$update": {"dna_sequence": {"$update": {"accession": "AJ295342.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Brucella anthropi"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36233": {"$update": {"category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi."}}}}}, "$insert": {"CARD_short_name": "OCH-4"}}, "772": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"960": {"$update": {"dna_sequence": {"$update": {"accession": "AY265890.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-6"}}, "4596": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6971": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ECM-1"}}, "779": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1053": {"$update": {"dna_sequence": {"$update": {"accession": "KF297579.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-47"}}, "76": {"$update": {"model_sequences": {"$update": {"sequence": {"8240": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGTGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATCGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "891", "accession": "AM176554.2", "fmin": "30", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47134.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEVLPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-79"}}, "75": {"$update": {"ARO_description": "fusH is a highly specific fusidic acid esterase found in Streptomyces lividans.", "model_sequences": {"$update": {"sequence": {"$update": {"201": {"$update": {"dna_sequence": {"$update": {"accession": "Z50108.1"}}}}}}}}, "ARO_category": {"$update": {"39459": {"$update": {"category_aro_description": "Enzymes that confer resistance to fusidic acid by inactivation."}}}}}, "$insert": {"CARD_short_name": "fusH"}}, "74": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1636": {"$update": {"dna_sequence": {"$update": {"accession": "AF132290.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-18"}}, "73": {"$update": {"ARO_description": "OXA-35 is a beta-lactamase found in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"975": {"$update": {"dna_sequence": {"$update": {"accession": "AF315786.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-35"}}, "72": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1874": {"$update": {"dna_sequence": {"$update": {"accession": "AF535130.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-42"}}, "71": {"$update": {"ARO_description": "QnrB66 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"157": {"$update": {"dna_sequence": {"$update": {"accession": "KC580655.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB66"}}, "70": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1749": {"$update": {"dna_sequence": {"$update": {"accession": "KF361506.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-208"}}, "5247": {"$insert": {"CARD_short_name": "PDC-109"}}, "5438": {"$insert": {"CARD_short_name": "PDC-308"}}, "944": {"$update": {"ARO_description": "bcrB is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance.", "model_sequences": {"$update": {"sequence": {"$update": {"585": {"$update": {"dna_sequence": {"$update": {"accession": "L20573.1"}}}}}}}}}, "$insert": {"CARD_short_name": "bcrB"}}, "79": {"$update": {"ARO_description": "VIM-37 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1655": {"$update": {"dna_sequence": {"$update": {"accession": "JX982636.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-16"}}, "5362": {"$insert": {"CARD_short_name": "PDC-222"}}, "5363": {"$insert": {"CARD_short_name": "PDC-223"}}, "1041": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"667": {"$update": {"dna_sequence": {"$update": {"accession": "HQ433550.1"}}}}}}}}}, "$insert": {"CARD_short_name": "MexS"}}, "1040": {"$update": {"ARO_description": "OXA-95 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1539": {"$update": {"dna_sequence": {"$update": {"accession": "DQ519089.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-95"}}, "1047": {"$update": {"ARO_description": "catS is a chromosome-encoded variant of the cat gene found in Streptococcus pyogenes.", "model_sequences": {"$update": {"sequence": {"$update": {"6245": {"$update": {"dna_sequence": {"$update": {"accession": "X74948.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catS"}}, "1046": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"519": {"$update": {"dna_sequence": {"$update": {"accession": "GQ205627.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vgaD"}}, "1045": {"$update": {"model_name": "ErmO-srmA"}, "$insert": {"CARD_short_name": "ErmO-srmA"}}, "1044": {"$update": {"ARO_description": "CTX-M-22 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1334": {"$update": {"dna_sequence": {"$update": {"accession": "AY080894.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-22"}}, "609": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"173": {"$update": {"dna_sequence": {"$update": {"accession": "D78168.1"}}}}}}}}}, "$insert": {"CARD_short_name": "emrK"}}, "1048": {"$update": {"ARO_description": "QnrB33 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii.", "model_sequences": {"$update": {"sequence": {"$update": {"468": {"$update": {"dna_sequence": {"$update": {"accession": "JN173055.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB33"}}, "1681": {"$update": {"ARO_description": "APH(4)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in Pseudomonas pseudomallei.", "model_sequences": {"$update": {"sequence": {"$update": {"262": {"$update": {"dna_sequence": {"$update": {"accession": "X74325.1"}}}}}}}}, "ARO_category": {"$update": {"36294": {"$update": {"category_aro_description": "Phosphorylation of hygromycin on the hydroxyl group at position 4."}}}}}, "$insert": {"CARD_short_name": "APH(4)-Ib"}}, "1680": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"578": {"$update": {"dna_sequence": {"$update": {"accession": "AY768531.1"}}}}}}}}}, "$insert": {"CARD_short_name": "macA"}}, "1683": {"$update": {"ARO_description": "QnrB67 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii.", "model_sequences": {"$update": {"sequence": {"$update": {"192": {"$update": {"dna_sequence": {"$update": {"accession": "KC580656.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB67"}}, "1682": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"330": {"$update": {"dna_sequence": {"$update": {"accession": "DQ677333.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA24"}}, "1685": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1714": {"$update": {"dna_sequence": {"$update": {"accession": "AF535128.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-40"}}, "1684": {"$update": {"ARO_description": "LEN-18 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8140": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTTTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGGTCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGCTCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM850908.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12346.2", "sequence": "MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTVGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVLYLRDTPASMAERNQHIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-18"}}, "1687": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"820": {"$update": {"dna_sequence": {"$update": {"accession": "AY112998.1"}}}}}}}}, "model_name": "cphA3"}, "$insert": {"CARD_short_name": "cphA3"}}, "1686": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1931": {"$update": {"dna_sequence": {"$update": {"accession": "AF350424.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-34"}}, "1689": {"$update": {"ARO_description": "Also known as vanRO, is a vanR variant found in the vanO gene cluster.", "model_name": "vanR gene in vanO cluster", "ARO_name": "vanR gene in vanO cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanO_cl"}}, "1688": {"$update": {"ARO_description": "CTX-M-90 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1782": {"$update": {"dna_sequence": {"$update": {"accession": "FJ907381.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-90"}}, "3983": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-39"}}, "4303": {"$insert": {"CARD_short_name": "ADC-238"}}, "4302": {"$insert": {"CARD_short_name": "ADC-237"}}, "1269": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1756": {"$update": {"dna_sequence": {"$update": {"accession": "JF273470.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-192"}}, "1268": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1020": {"$update": {"dna_sequence": {"$update": {"accession": "KM087839.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-115"}}, "4307": {"$insert": {"CARD_short_name": "ADC-241"}}, "4306": {"$insert": {"CARD_short_name": "ADC-240"}}, "4305": {"$insert": {"CARD_short_name": "ADC-24"}}, "668": {"$update": {"ARO_description": "CTX-M-65 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1029": {"$update": {"dna_sequence": {"$update": {"accession": "EF418608.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-65"}}, "667": {"$update": {"ARO_description": "ACT-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8151": {"dna_sequence": {"partial": "0", "sequence": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATGAGGGTCAGCCGCACTACTTCACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACTCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGTGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCAAGGATAACGCCTCTCTGTTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCAGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTTGCACTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCAGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "fmax": "1173", "accession": "U58495.2", "fmin": "27", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAC45086.2", "sequence": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-1"}}, "1262": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"915": {"$update": {"dna_sequence": {"$update": {"accession": "JX121116.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-149"}}, "4309": {"$insert": {"CARD_short_name": "ADC-243"}}, "664": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1508": {"$update": {"dna_sequence": {"$update": {"accession": "FJ360626.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-43"}}, "663": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1660": {"$update": {"dna_sequence": {"$update": {"accession": "KM926621.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-36"}}, "1266": {"$update": {"ARO_description": "ANT(4')-IIa is a plasmid-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa and Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"190": {"$update": {"dna_sequence": {"$update": {"accession": "M98270.1"}}}}}}}}, "ARO_category": {"$update": {"36368": {"$update": {"category_aro_description": "Nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 4'."}}}}}, "$insert": {"CARD_short_name": "ANT(4')-IIa"}}, "1265": {"$update": {"ARO_description": "MIR-4 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8148": {"dna_sequence": {"partial": "0", "sequence": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTTCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCACGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAAGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTAGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "fmax": "1175", "accession": "EF417572.2", "fmin": "29", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ABN69112.2", "sequence": "MMTKSLSCALLLSVASAAFAAPMFEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ"}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-4"}}, "1264": {"$update": {"ARO_description": "smeC is an outer membrane multidrug efflux protein of the smeABC complex in Stenotrophomonas maltophilia.", "model_sequences": {"$update": {"sequence": {"$update": {"155": {"$update": {"dna_sequence": {"$update": {"accession": "AF173226.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "smeC"}}, "5102": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-797"}}, "5653": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-116"}}, "5094": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-786"}}, "4531": {"$insert": {"CARD_short_name": "CTX-M-202"}}, "5241": {"$insert": {"CARD_short_name": "PDC-101"}}, "5103": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-798"}}, "1913": {"$update": {"ARO_description": "dfrK is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus.", "model_sequences": {"$update": {"sequence": {"$update": {"50": {"$update": {"dna_sequence": {"$update": {"accession": "FN812951.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrK"}}, "4212": {"$insert": {"CARD_short_name": "ADC-141"}}, "67": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1462": {"$update": {"dna_sequence": {"$update": {"accession": "KJ427797.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-391"}}, "3128": {"$insert": {"CARD_short_name": "MCR-3.11"}}, "1912": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-13"}}, "4595": {"$insert": {"CARD_short_name": "EC-8"}}, "1889": {"$update": {"ARO_description": "NDM-4 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"939": {"$update": {"dna_sequence": {"$update": {"accession": "JQ348841.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-4"}}, "5106": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-801"}}, "5107": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-802"}}, "5095": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-787"}}, "5240": {"$insert": {"CARD_short_name": "PDC-100"}}, "1469": {"$update": {"ARO_description": "Efflux protein facT confers resistance to factumycin. The gene has been heterologously expressed in S. coelicolor and its function confirmed. It is possible that this gene can export other kirromycin-like elfamycins, but this has not been tested.", "model_sequences": {"$update": {"sequence": {"$update": {"687": {"$update": {"dna_sequence": {"$update": {"accession": "JQ768046.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Streptomyces sp. WAC05292"}}}}}}}}}, "$insert": {"CARD_short_name": "facT"}}, "1917": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"606": {"$update": {"dna_sequence": {"$update": {"accession": "AF090987.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(30)"}}, "3977": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-9"}}, "520": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4558": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}, "model_name": "AcrS", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "AcrS"}}, "1467": {"$update": {"ARO_description": "LEN-22 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8179": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCCCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGACAAGACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM850912.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12350.2", "sequence": "MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSPRSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-22"}}, "5105": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-800"}}, "1461": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"920": {"$update": {"dna_sequence": {"$update": {"accession": "EU342351.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-63"}}, "1823": {"$update": {"ARO_description": "OXY-1-3 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"815": {"$update": {"dna_sequence": {"$update": {"accession": "AY077482.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-1-3"}}, "1463": {"$update": {"ARO_description": "GES-19 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1090": {"$update": {"dna_sequence": {"$update": {"accession": "JN596280.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-19"}}, "1019": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1867": {"$update": {"dna_sequence": {"$update": {"accession": "AB204557.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-21"}}, "1317": {"$update": {"ARO_description": "CTX-M-3 is a beta-lactamase found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"1965": {"$update": {"dna_sequence": {"$update": {"accession": "Y10278.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CTX-M-3"}}, "1316": {"$update": {"ARO_description": "catB6 is a plasmid-encoded variant of the cat gene found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"295": {"$update": {"dna_sequence": {"$update": {"accession": "AJ223604.1"}}}}}}}}, "model_name": "Pseudomonas aeruginosa catB6", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "Paer_catB6"}}, "1315": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"257": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}}, "$insert": {"CARD_short_name": "mdtC"}}, "1314": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1208": {"$update": {"dna_sequence": {"$update": {"accession": "JN861782.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-214"}}, "2092": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Kaer_acrR_MULT"}}, "1312": {"$update": {"ARO_description": "OXA-111 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1677": {"$update": {"dna_sequence": {"$update": {"accession": "EF650037.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-111"}}, "1311": {"$update": {"ARO_description": "OXY-5-2 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"816": {"$update": {"dna_sequence": {"$update": {"accession": "AJ871871.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-5-2"}}, "1310": {"$update": {"ARO_description": "IMP-10 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1671": {"$update": {"dna_sequence": {"$update": {"accession": "AB074433.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-10"}}, "3276": {"$update": {"ARO_description": "MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid."}, "$insert": {"CARD_short_name": "Saur_LmrS"}}, "1319": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2021": {"$update": {"dna_sequence": {"$update": {"accession": "JX121114.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-147"}}, "1318": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"178": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "evgS"}}, "4608": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-10"}}, "3976": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-5"}}, "4239": {"$insert": {"CARD_short_name": "ADC-171"}}, "4238": {"$insert": {"CARD_short_name": "ADC-170"}}, "4237": {"$insert": {"CARD_short_name": "ADC-169"}}, "4236": {"$insert": {"CARD_short_name": "ADC-168"}}, "4235": {"$insert": {"CARD_short_name": "ADC-167"}}, "4234": {"$insert": {"CARD_short_name": "ADC-166"}}, "4233": {"$insert": {"CARD_short_name": "ADC-165"}}, "4232": {"$insert": {"CARD_short_name": "ADC-164"}}, "4231": {"$insert": {"CARD_short_name": "ADC-163"}}, "4230": {"$insert": {"CARD_short_name": "ADC-162"}}, "5591": {"$insert": {"CARD_short_name": "PDC-465"}}, "5590": {"$insert": {"CARD_short_name": "PDC-463"}}, "5593": {"$insert": {"CARD_short_name": "PDC-467"}}, "5592": {"$insert": {"CARD_short_name": "PDC-466"}}, "5595": {"$insert": {"CARD_short_name": "PDC-469"}}, "5594": {"$insert": {"CARD_short_name": "PDC-468"}}, "5597": {"$insert": {"CARD_short_name": "PDC-471"}}, "5596": {"$insert": {"CARD_short_name": "PDC-470"}}, "5599": {"$insert": {"CARD_short_name": "PDC-473"}}, "528": {"$update": {"ARO_description": "OCH-8 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi.", "model_sequences": {"$update": {"sequence": {"$update": {"1979": {"$update": {"dna_sequence": {"$update": {"accession": "DQ489307.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Brucella anthropi"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "EBR-4"}}, "1100": {"$update": {"ARO_description": "OXA-245 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"805": {"$update": {"dna_sequence": {"$update": {"accession": "JX438001.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-245"}}, "1011": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2036": {"$update": {"dna_sequence": {"$update": {"accession": "Y17584.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-29"}}, "3445": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-280"}}, "4609": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, not yet released.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-25"}}, "3444": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-279"}}, "22": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"940": {"$update": {"dna_sequence": {"$update": {"accession": "JN848330.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-10"}}, "5367": {"$insert": {"CARD_short_name": "PDC-228"}}, "3447": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-282"}}, "3948": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly added to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-208"}}, "3949": {"$update": {"ARO_description": "A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-206"}}, "319": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2111": {"$update": {"dna_sequence": {"$update": {"accession": "KP050485.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-366"}}, "862": {"$update": {"ARO_description": "IMP-16 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"836": {"$update": {"dna_sequence": {"$update": {"accession": "AJ584652.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-16"}}, "3403": {"$update": {"model_name": "Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide"}, "$insert": {"CARD_short_name": "Mtub_rpsA_PZA"}}, "4214": {"$insert": {"CARD_short_name": "ADC-144"}}, "313": {"$update": {"ARO_description": "OXA-143 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1291": {"$update": {"dna_sequence": {"$update": {"accession": "GQ861437.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-167"}}, "311": {"$update": {"ARO_description": "IND-2 is a beta-lactamase found in Chryseobacterium indologenes.", "model_sequences": {"$update": {"sequence": {"$update": {"774": {"$update": {"dna_sequence": {"$update": {"accession": "AF219127.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-2"}}, "310": {"$update": {"model_sequences": {"$update": {"sequence": {"8187": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCAGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "891", "accession": "AM176553.2", "fmin": "30", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47133.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASSRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-78"}}, "3944": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6307": {"$update": {"dna_sequence": {"$update": {"accession": "NG_068180.1"}}, "protein_sequence": {"$update": {"accession": "WP_071537493.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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Directed submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-210"}}, "4606": {"$update": {"ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-16"}}, "4216": {"$insert": {"CARD_short_name": "ADC-146"}}, "3443": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-276"}}, "4210": {"$insert": {"CARD_short_name": "ADC-139"}}, "2024": {"$update": {"ARO_description": "ACC-2 is a beta-lactamase found in Hafnia alvei.", "model_sequences": {"$update": {"sequence": {"$update": {"1852": {"$update": {"dna_sequence": {"$update": {"accession": "AF180952.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-2"}}, "4129": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-34"}}, "4128": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-8"}}, "4198": {"$insert": {"CARD_short_name": "ADC-127"}}, "4123": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6498": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-1a"}}, "4122": {"$insert": {"CARD_short_name": "AAK-1"}}, "4199": {"$insert": {"CARD_short_name": "ADC-128"}}, "4127": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-7"}}, "2754": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4496": {"$update": {"protein_sequence": {"$update": {"accession": "ENU91137.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "ANT(3'')-IIb"}}, "4125": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6500": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-1c"}}, "4124": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6499": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-1b"}}, "1335": {"$update": {"ARO_description": "QnrB8 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"8143": {"dna_sequence": {"partial": "0", "sequence": "ATGACTCTGGCATTAGTTGGCGAAAAAATTGACAGAAACCGCTTCACCGGTGAAAAAGTTGAAAATAGCACTTTTTTTAACTGTGATTTTTCGGGTGCCGACCTTAGCGGTACTGAATTTATCGGCTGTCAGTTCTATGATCGAGAAAGCCAGAAAGGGTGCAATTTCAGTCGCGCAATACTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAACGTCAGTGCGTTGGGCATAGAAATTCGCCACTGCCGCGCACAGGGTGCAGATTTTCGCGGCGCAAGTTTCATGAATATGATCACCACGCGCACCTGGTTTTGCAGCGCATATATCACTAATACCAATCTAAGCTACGCCAACTTTTCGAAGGCCGTGCTTGAAAAGTGCGAATTGTGGGAAAATCGCTGGATGGGAACTCAGGTACTGGGTGCGACGTTGAGTGGTTCCGATCTCTCCGGTGGCGAGTTTTCGTCGTTCGACTGGCGGACGGCAAATTTCACGCACTGTGATTTGACCAATTCAGAACTGGGTGATTTAGATATTCGGGGCGTCGATTTACAAGGTGTCAAATTGGACAACTATCAGGCCGCATTGCTCATGGAACGTCTTGGCATCGCTGTGATTGGCTAG", "fmax": "645", "accession": "EU043312.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Citrobacter freundii", "NCBI_taxonomy_id": "546", "NCBI_taxonomy_cvterm_id": "36915"}, "protein_sequence": {"accession": "ABW03157.2", "sequence": "MTLALVGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAILKDAIFKSCDLSMADFRNVSALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKAVLEKCELWENRWMGTQVLGATLSGSDLSGGEFSSFDWRTANFTHCDLTNSELGDLDIRGVDLQGVKLDNYQAALLMERLGIAVIG"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB8"}}, "2755": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4495": {"$update": {"protein_sequence": {"$update": {"accession": "ENU37733.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "ANT(3'')-IIc"}}, "5689": {"$insert": {"CARD_short_name": "VHH-1"}}, "5688": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-27"}}, "1334": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2020": {"$update": {"dna_sequence": {"$update": {"accession": "GQ390808.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-126"}}, "5685": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-24"}}, "2020": {"$insert": {"CARD_short_name": "tetO"}}, "5687": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-26"}}, "5686": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-25"}}, "5681": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-20"}}, "1337": {"$insert": {"CARD_short_name": "baeR"}}, "5683": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-22"}}, "2021": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1065": {"$update": {"dna_sequence": {"$update": {"accession": "JX121131.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-82"}}, "1336": {"$update": {"ARO_description": "Bacillus cereus beta-lactamase II is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 5/B/6.", "model_sequences": {"$update": {"sequence": {"$update": {"1699": {"$update": {"dna_sequence": {"$update": {"accession": "M19530.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BcII"}}, "2750": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4499": {"$update": {"protein_sequence": {"$update": {"accession": "EPF73263.1"}}}}}}}}, "model_name": "APH(3')-VIIIb", "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-VIIIb"}}, "4706": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-81"}}, "4192": {"$insert": {"CARD_short_name": "ADC-119"}}, "2751": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4068": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Acinetobacter gerneri DSM 14967 = CIP 107464 = MTCC 9824"}}, "protein_sequence": {"$update": {"accession": "ENV34035.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-IX"}}, "4604": {"$update": {"ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-14"}}, "4705": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-80"}}, "4193": {"$insert": {"CARD_short_name": "ADC-120"}}, "4218": {"$insert": {"CARD_short_name": "ADC-148"}}, "1822": {"$update": {"ARO_description": "Point mutation in Staphylococcus aureus resulting in aminocoumarin resistance."}, "$insert": {"CARD_short_name": "Saur_gyrB_AMU"}}, "1333": {"$update": {"ARO_description": "Also known as vanHD, is a vanH variant in the vanD gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"428": {"$update": {"dna_sequence": {"$update": {"accession": "AY082011.1"}}}}}}}}, "model_name": "vanH gene in vanD cluster", "ARO_name": "vanH gene in vanD cluster"}, "$insert": {"CARD_short_name": "vanH_in_vanD_cl"}}, "1709": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1952": {"$update": {"dna_sequence": {"$update": {"accession": "AF535127.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-599"}}, "1997": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"158": {"$update": {"dna_sequence": {"$update": {"accession": "M57437.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tlrC"}}, "4313": {"$insert": {"CARD_short_name": "ADC-247"}}, "4702": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-77"}}, "4057": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6424": {"$update": {"dna_sequence": {"$update": {"accession": "NG_056182.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-573"}}, "4056": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6423": {"$update": {"dna_sequence": {"$update": {"accession": "NG_056179.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-570"}}, "4055": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6422": {"$update": {"dna_sequence": {"$update": {"accession": "NG_070748.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-926"}}, "4054": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6421": {"$update": {"dna_sequence": {"$update": {"accession": "NG_065880.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-835"}}, "4053": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6420": {"$update": {"dna_sequence": {"$update": {"accession": "NG_052519.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-541"}}, "4052": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6419": {"$update": {"dna_sequence": {"$update": {"accession": "NG_062269.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-737"}}, "4051": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6418": {"$update": {"dna_sequence": {"$update": {"accession": "NG_062301.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-681"}}, "4050": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6416": {"$update": {"dna_sequence": {"$update": {"accession": "NG_068179.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-543"}}, "2028": {"$update": {"ARO_description": "QnrB43 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB43"}}, "4605": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6980": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-15"}}, "4700": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-901"}}, "3843": {"$insert": {"CARD_short_name": "AAC(6')-Ib-cr6"}}, "5674": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-11"}}, "5465": {"$insert": {"CARD_short_name": "PDC-335"}}, "3407": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "HERA-2"}}, "2299": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3565": {"$update": {"dna_sequence": {"$update": {"accession": "BX571856.1"}}, "protein_sequence": {"$update": {"accession": "CAG39047.1"}}}}}}}}, "model_name": "Staphylococcus aureus walK with mutation conferring resistance to daptomycin"}, "$insert": {"CARD_short_name": "Saur_walK_DAP"}}, "2298": {"$update": {"ARO_category": {"$update": {"36719": {"$update": {"category_aro_description": "Sao Paulo metallo-beta-lactamase (SPM-1) confers resistance to carbapenem in Pseudomonas aeruginosa."}}}}}, "$insert": {"CARD_short_name": "SPM-1"}}, "3614": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "HERA-8"}}, "3617": {"$insert": {"CARD_short_name": "IMI-8"}}, "2293": {"$update": {"model_name": "Bacillus subtilis pgsA with mutation conferring resistance to daptomycin"}, "$insert": {"CARD_short_name": "Bsub_pgsA_DAP"}}, "3619": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5817": {"$update": {"dna_sequence": {"$update": {"accession": "LC055762.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-52"}}, "2291": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3556": {"$update": {"dna_sequence": {"$update": {"accession": "AY152390.1"}}, "protein_sequence": {"$update": {"accession": "AAN28945.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ctra_murA_FOF"}}, "2290": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3555": {"$update": {"dna_sequence": {"$update": {"accession": "HE608151.1"}}, "protein_sequence": {"$update": {"accession": "CCE36834.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Mtub_murA_FOF"}}, "2297": {"$insert": {"CARD_short_name": "Efae_liaR_DAP"}}, "2296": {"$insert": {"CARD_short_name": "Efae_liaS_DAP"}}, "631": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1077": {"$update": {"dna_sequence": {"$update": {"accession": "Y17582.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-21"}}, "2294": {"$insert": {"CARD_short_name": "Cjej_gyrA_FLO"}}, "1049": {"$update": {"ARO_description": "MOX-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8161": {"dna_sequence": {"partial": "0", "sequence": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGAGCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "fmax": "1381", "accession": "D13304.2", "fmin": "232", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "BAA02563.2", "sequence": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-1"}}, "5301": {"$insert": {"CARD_short_name": "PDC-162"}}, "5679": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-17"}}, "5084": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-775"}}, "5252": {"$insert": {"CARD_short_name": "PDC-114"}}, "632": {"$update": {"ARO_description": "Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)."}, "$insert": {"CARD_short_name": "basR"}}, "5196": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-903"}}, "3845": {"$insert": {"CARD_short_name": "AAC(6')-Ib-cr8"}}, "4363": {"$insert": {"CARD_short_name": "AXC-1"}}, "2368": {"$insert": {"CARD_short_name": "ADC-79"}}, "2367": {"$insert": {"CARD_short_name": "ADC-78"}}, "2366": {"$insert": {"CARD_short_name": "ADC-77"}}, "2365": {"$insert": {"CARD_short_name": "ADC-76"}}, "2364": {"$insert": {"CARD_short_name": "ADC-75"}}, "2363": {"$insert": {"CARD_short_name": "ADC-74"}}, "2362": {"$insert": {"CARD_short_name": "ADC-61"}}, "1244": {"$update": {"ARO_description": "OXY-5-1 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"2017": {"$update": {"dna_sequence": {"$update": {"accession": "AJ871869.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-709"}}, "865": {"$update": {"ARO_description": "OXA-244 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"2006": {"$update": {"dna_sequence": {"$update": {"accession": "JX438000.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-711"}}, "5191": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-894"}}, "5025": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-713"}}, "5024": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-712"}}, "5027": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-715"}}, "3844": {"$insert": {"CARD_short_name": "AAC(6')-Ib-cr7"}}, "1861": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1268": {"$update": {"dna_sequence": {"$update": {"accession": "AF452105.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-15"}}, "1860": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1205": {"$update": {"dna_sequence": {"$update": {"accession": "HM488986.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-165"}}, "1863": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1006": {"$update": {"dna_sequence": {"$update": {"accession": "AF300454.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-3"}}, "1862": {"$update": {"ARO_description": "OXA-109 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1449": {"$update": {"dna_sequence": {"$update": {"accession": "EF650035.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-109"}}, "1865": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"778": {"$update": {"dna_sequence": {"$update": {"accession": "HE819401.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-5"}}, "1864": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"864": {"$update": {"dna_sequence": {"$update": {"accession": "JQ711185.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-67"}}, "1867": {"$update": {"ARO_description": "CTX-M-116 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"824": {"$update": {"dna_sequence": {"$update": {"accession": "JF966749.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-116"}}, "1866": {"$update": {"ARO_description": "KPC-7 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1517": {"$update": {"dna_sequence": {"$update": {"accession": "EU729727.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-7"}}, "1869": {"$update": {"ARO_description": "OXY-2-6 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"8255": {"dna_sequence": {"partial": "0", "sequence": "ATGATAAAAAGTTCGTGGCGTAAAATTGCAATGCTAGCCGCCGCCGTTCCGCTGCTGCTGGCGAGCAGCGCACTGTGGGCCAGTACCGATGCTATCCATCAGAAGCTGACAGATCTCGAGAAGCGTTCAGGCGGCAGGTTGGGCGTGGCGCTAATCAACACGGCAGATAATTCTCAAATCTTATATCGCGGCGACGAGCGTTTTGCCATGTGCAGCACCAGTAAAGTGATGGCCGCCGCCGCGGTATTAAAACAGAGCGAAAGCAATAAAGAGGTGGTAAATAAAAGGCTGGAGATTAACGCAGCCGATTTGGTGGTCTGGAGTCCGATTACCGAAAAACATCTCCAGAGCGGAATGACGCTGGCTGAGCTAAGCGCGGCGACGCTGCAATATAGCGACAATACGGCGATGAATCTGATCATCGGCTACCTTGGCGGGCCGGAAAAAGTCACCGCCTTCGCCCGCAGTATCGGCGATGCCACCTTTCGTCTCGATCGTACGGAGCCCACGCTGAATACCGCCATCCCGGGCGATGAGCGTGATACCAGCACGCCGCTGGCGATGGCTGAAAGCCTACGCAAGCTGACGCTTGGCGATGCGCTGGGCGAACAGCAACGCGCCCAGTTAGTCACCTGGCTGAAAGGCAATACCACCGGCGGGCAAAGCATTCGCGCGGGCCTGCCTGAAAGCTGGGTGGTCGGCGATAAAACCGGCGCCGGAGATTACGGCACCACCAATGATATTGCGGTTATCTGGCCGGAAGATCACGCTCCGCTGGTATTAGTCACCTACTTTACCCAGCCGCAGCAGGATGCGAAAAACCGCAAAGAGGTGTTAGCCGCAGCGGCAAAAATCGTGACCGAAGGGCTTTAA", "fmax": "1056", "accession": "AY077485.2", "fmin": "183", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella oxytoca", "NCBI_taxonomy_id": "571", "NCBI_taxonomy_cvterm_id": "36788"}, "protein_sequence": {"accession": "AAL78278.2", "sequence": "MIKSSWRKIAMLAAAVPLLLASSALWASTDAIHQKLTDLEKRSGGRLGVALINTADNSQILYRGDERFAMCSTSKVMAAAAVLKQSESNKEVVNKRLEINAADLVVWSPITEKHLQSGMTLAELSAATLQYSDNTAMNLIIGYLGGPEKVTAFARSIGDATFRLDRTEPTLNTAIPGDERDTSTPLAMAESLRKLTLGDALGEQQRAQLVTWLKGNTTGGQSIRAGLPESWVVGDKTGAGDYGTTNDIAVIWPEDHAPLVLVTYFTQPQQDAKNRKEVLAAAAKIVTEGL"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-6"}}, "1868": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1162": {"$update": {"dna_sequence": {"$update": {"accession": "AF427128.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-82"}}, "3727": {"$insert": {"CARD_short_name": "Mtub_mshA_INH"}}, "4490": {"$insert": {"CARD_short_name": "CTX-M-140"}}, "4930": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-604"}}, "965": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1610": {"$update": {"dna_sequence": {"$update": {"accession": "KF203107.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-333"}}, "4932": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-606"}}, "4933": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-607"}}, "960": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1155": {"$update": {"dna_sequence": {"$update": {"accession": "AM286274.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-137"}}, "961": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1877": {"$update": {"dna_sequence": {"$update": {"accession": "EF373969.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-93"}}, "962": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1533": {"$update": {"dna_sequence": {"$update": {"accession": "KF297585.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-356"}}, "963": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1022": {"$update": {"dna_sequence": {"$update": {"accession": "JX049132.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-69"}}, "634": {"$update": {"ARO_description": "smeF is an outer membrane multidrug efflux protein of the smeDEF complex in Stenotrophomonas maltophilia.", "model_sequences": {"$update": {"sequence": {"$update": {"509": {"$update": {"dna_sequence": {"$update": {"accession": "AJ252200.1"}}}}}}}}}, "$insert": {"CARD_short_name": "smeF"}}, "5190": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-22"}}, "968": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1503": {"$update": {"dna_sequence": {"$update": {"accession": "KM087851.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-15"}}, "969": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1805": {"$update": {"dna_sequence": {"$update": {"accession": "JX679208.1"}}}}}}}}, "ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-8"}}, "4688": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catP"}}, "5577": {"$insert": {"CARD_short_name": "PDC-450"}}, "2109": {"$update": {"ARO_description": "Point mutation in Mycobacterium tuberculosis gyrB resulting in fluoroquinolone resistance.", "model_name": "Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Mtub_gyrB_FLO"}}, "2108": {"$update": {"ARO_description": "Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to GE2270A."}, "$insert": {"CARD_short_name": "Efac_EFTu_GE2A"}}, "5251": {"$insert": {"CARD_short_name": "PDC-113"}}, "5576": {"$insert": {"CARD_short_name": "PDC-448"}}, "2103": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-3"}}, "2102": {"$update": {"model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B"}, "$insert": {"CARD_short_name": "Msme_16rrsB_HGM"}}, "2100": {"$insert": {"CARD_short_name": "Mche_16S_AMK"}}, "2106": {"$update": {"ARO_description": "Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A.", "model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A"}, "$insert": {"CARD_short_name": "Msme_16rrsA_KAN"}}, "2105": {"$update": {"ARO_description": "Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to neomycin."}, "$insert": {"CARD_short_name": "Mabs_16S_NEO"}}, "2104": {"$update": {"ARO_description": "Point mutation in Ureaplasma urealyticum parC resulting in fluoroquinolone resistance.", "model_name": "Ureaplasma urealyticum parC conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Uure_parC_FLO"}}, "5115": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-809"}}, "5117": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-813"}}, "5116": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-811"}}, "5111": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-806"}}, "5110": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7485": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-805"}}, "5113": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-808"}}, "5112": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-807"}}, "5573": {"$insert": {"CARD_short_name": "PDC-445"}}, "662": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1882": {"$update": {"dna_sequence": {"$update": {"accession": "EF468463.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-162"}}, "5119": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-815"}}, "5118": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-814"}}, "5572": {"$insert": {"CARD_short_name": "PDC-444"}}, "5088": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-185"}}, "876": {"$update": {"ARO_description": "smeE is the RND protein of the efflux complex smeDEF in Stenotrophomonas maltophilia.", "model_sequences": {"$update": {"sequence": {"$update": {"564": {"$update": {"dna_sequence": {"$update": {"accession": "AJ252200.1"}}}}}}}}}, "$insert": {"CARD_short_name": "smeE"}}, "877": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1851": {"$update": {"dna_sequence": {"$update": {"accession": "GQ390806.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "model_name": "AcrAB-TolC"}, "$insert": {"CARD_short_name": "AcrAB-TolC"}}, "4597": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6972": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ECV-1"}}, "2031": {"$update": {"ARO_description": "OXA-173 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1924": {"$update": {"dna_sequence": {"$update": {"accession": "HM113559.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-53"}}, "891": {"$update": {"ARO_description": "QnrB37 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"679": {"$update": {"dna_sequence": {"$update": {"accession": "JN173059.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB37"}}, "892": {"$update": {"ARO_description": "APH(6)-Ic is a transposon-encoded aminoglycoside phosphotransferase in S. enterica, P. aeruginosa and E. coli.", "model_sequences": {"$update": {"sequence": {"$update": {"404": {"$update": {"dna_sequence": {"$update": {"accession": "X01702.1"}}}}}}}}, "ARO_category": {"$update": {"36290": {"$update": {"category_aro_description": "Phosphorylation of streptomycin on the hydroxyl group at position 6."}}}}}, "$insert": {"CARD_short_name": "APH(6)-Ic"}}, "4937": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-611"}}, "894": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1444": {"$update": {"dna_sequence": {"$update": {"accession": "HE819404.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-90"}}, "895": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-383"}}, "898": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-9"}}, "899": {"$update": {"ARO_description": "OXA-94 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1466": {"$update": {"dna_sequence": {"$update": {"accession": "DQ519088.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-904"}}, "5182": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-885"}}, "4939": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-613"}}, "1788": {"$update": {"ARO_description": "ACT-6 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1972": {"$update": {"dna_sequence": {"$update": {"accession": "FJ237366.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-6"}}, "1789": {"$update": {"ARO_description": "QnrB44 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB44"}}, "768": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1947": {"$update": {"dna_sequence": {"$update": {"accession": "AY065991.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-43"}}, "769": {"$update": {"ARO_description": "KPC-11 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1710": {"$update": {"dna_sequence": {"$update": {"accession": "HM066995.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-11"}}, "4565": {"$insert": {"CARD_short_name": "CTX-M-236"}}, "4368": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BEL-4"}}, "1612": {"$update": {"model_sequences": {"$update": {"sequence": {"8141": {"dna_sequence": {"partial": "0", "sequence": "ATGGCAGGTCCGCAAGACCGTCCGCGAGGGCGCGGACCCTCCTCCGGTCGCCCGCAGCGGCCGGTGGGCGGCCGCAGCCAGCGCGACCGCGACCGGCGGGTCCTCGGCCAGAACTTCCTGCGCGACCCGGCGACCATCCGGCGCATCGCCGACGCCGCCGACGTCGACCCCGACGGGCTCGTCGTCGAGGCGGGTCCCGGCGAAGGGCTGCTCACCCGCGAGCTCGCCCGACGCGCCGGGCGGGTACGCACCTACGAGCTGGACCAGCGCCTCGCGCGACGACTCTCGACCGACCTGGCCCAGGAGACGAGCATCGAGGTCGTCCACGCCGACTTCCTGACCGCGCCTCACCCCGAGGAGCCGTTCCAGTTCGTCGGCGCGATCCCCTACGGCATCACCTCCGCCATCGTCGACTGGTGCCTGACCGCCCCGACCCTGACGTCGGCGACCCTCGTGACCCAGCAGGAGTTCGCGCGCAAGCGGACGGGTGACTACGGACGGTGGACGGCCCTCACCGTCACCACGTGGCCGACCTTCGAGTGGCAGTACGTCGCCAAGGTCGACCGCACGCTGTTCACACCGGTGCCGCGCGTGCACTCCGCGATCATGCGGCTGCGCCGCCGCCCACAGCCCCTCCTGCGCGACGCGGCGGCGAGGTCGCGCTTCGCGGACATGGTGGAGATCGGCTTCGTCGGCAAGGGCGGCAGCCTCTACCGGTCGCTGACCCGGGAGTGGCCGCGCTCGAAGGTCGACAGCGCGTTCGCGCGCGCCGACGTCCACCACGACGAGATCGTCGCCTTCGTGCACCCCGACCAGTGGATCACGCTGTTCCAGCTCCTCGACGGGTCCCGTGGCGGCGCCGCGCGCGGACCGGGCGACCAGCGGGGGCGGCGCGGCCGCCCAGGCGGAGGCCCCCGGCCGGACGGTCGCGCGGGCGGCGGCCCGCGCCGCGACGCGGGCGGGCGCCGCACGGGTGACGGACGCGGAGGTCGCCCCCGTCCCCCGCGCGGCGGCCAGGCCTAG", "fmax": "13472", "accession": "AY623658.2", "fmin": "12449", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Aeromicrobium erythreum", "NCBI_taxonomy_id": "2041", "NCBI_taxonomy_cvterm_id": "40506"}, "protein_sequence": {"accession": "AAU93796.1", "sequence": "MAGPQDRPRGRGPSSGRPQRPVGGRSQRDRDRRVLGQNFLRDPATIRRIADAADVDPDGLVVEAGPGEGLLTRELARRAGRVRTYELDQRLARRLSTDLAQETSIEVVHADFLTAPHPEEPFQFVGAIPYGITSAIVDWCLTAPTLTSATLVTQQEFARKRTGDYGRWTALTVTTWPTFEWQYVAKVDRTLFTPVPRVHSAIMRLRRRPQPLLRDAAARSRFADMVEIGFVGKGGSLYRSLTREWPRSKVDSAFARADVHHDEIVAFVHPDQWITLFQLLDGSRGGAARGPGDQRGRRGRPGGGPRPDGRAGGGPRRDAGGRRTGDGRGGRPRPPRGGQA"}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmR"}}, "760": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1002": {"$update": {"dna_sequence": {"$update": {"accession": "X57972.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-6"}}, "761": {"$update": {"ARO_description": "GES-13 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1905": {"$update": {"dna_sequence": {"$update": {"accession": "GU169702.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-13"}}, "766": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1697": {"$update": {"dna_sequence": {"$update": {"accession": "EU024485.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-102"}}, "767": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1836": {"$update": {"dna_sequence": {"$update": {"accession": "JQ838185.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-207"}}, "764": {"$update": {"ARO_description": "FOX-2 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1031": {"$update": {"dna_sequence": {"$update": {"accession": "Y10282.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-2"}}, "765": {"$update": {"ARO_description": "QnrB7 is a plasmid-mediated quinolone resistance protein found in Enterobacter cloacae.", "model_sequences": {"$update": {"sequence": {"8172": {"dna_sequence": {"partial": "0", "sequence": "ATGGCTCTGGCACTCGTTGGCGAAAAAATTGACAGAAACCGTTTCACCGGTGAGAAAATTGAAAATAGTACATTTTTTAACTGTGATTTTTCAGGTGCCGACCTAAGTGGTACTGAATTTATCGGCTGTCAGTTCTATGATCGTGAAAGCCAGAAAGGGTGCAATTTTAGTCGTGCAATGCTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAATGCCAGTGCGCTGGGCATTGAAATTCGCCACTGCCGCGCACAAGGCGCAGATTTCCGCGGCGCAAGCTTTATGAATATGATCACTACACGCACCTGGTTTTGCAGCGCATATATCACTAACACAAATCTAAGCTACGCCAATTTTTCGAAAGTCGTGCTGGAAAAGTGTGAGCTGTGGGAAAACCGTTGGATGGGTGCCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTACGACTTTCGACTGGCGAGCAGCAAACTTCACACATTGCGATCTGACCAATTCGGAGTTGGGTGACTTAGATATTCGGGGCGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCATCGTTGCTCATGGAACGTCTTGGCATCGCGATTATTGGCTAG", "fmax": "645", "accession": "EU043311.3", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550", "NCBI_taxonomy_cvterm_id": "36884"}, "protein_sequence": {"accession": "ABW03156.3", "sequence": "MALALVGEKIDRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGAQVLGATFSGSDLSGGEFTTFDWRAANFTHCDLTNSELGDLDIRGVDLQGVKLDNYQASLLMERLGIAIIG"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB7"}}, "4440": {"$insert": {"CARD_short_name": "CDD-1"}}, "5193": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-900"}}, "1963": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1000": {"$update": {"dna_sequence": {"$update": {"accession": "JN416112.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-190"}}, "4569": {"$insert": {"CARD_short_name": "CTX-M-240"}}, "452": {"$update": {"ARO_description": "QnrVC4 is an integron-mediated quinolone resistance protein found in Aeromonas punctata.", "model_sequences": {"$update": {"sequence": {"$update": {"530": {"$update": {"dna_sequence": {"$update": {"accession": "GQ891757.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrVC4"}}, "4568": {"$insert": {"CARD_short_name": "CTX-M-239"}}, "5379": {"$insert": {"CARD_short_name": "PDC-241"}}, "5378": {"$insert": {"CARD_short_name": "PDC-24"}}, "1078": {"$update": {"ARO_description": "VIM-4 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1891": {"$update": {"dna_sequence": {"$update": {"accession": "AM087411.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-4"}}, "1079": {"$update": {"ARO_description": "OXA-161 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"881": {"$update": {"dna_sequence": {"$update": {"accession": "GQ202693.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-161"}}, "1076": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1632": {"$update": {"dna_sequence": {"$update": {"accession": "JX131372.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-37"}}, "1077": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2012": {"$update": {"dna_sequence": {"$update": {"accession": "AB983359.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-420"}}, "1074": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5871": {"$update": {"dna_sequence": {"$update": {"accession": "AY130286.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-3"}}, "1075": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1800": {"$update": {"dna_sequence": {"$update": {"accession": "Y17581.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-20"}}, "1072": {"$update": {"ARO_description": "OXA-37 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1134": {"$update": {"dna_sequence": {"$update": {"accession": "AY007784.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-37"}}, "1073": {"$update": {"ARO_description": "OKP-B-19 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8280": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAGGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCATGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCTGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACACCGCCGGCAATCTGCTGTTGAAGATCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGCTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTTGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGTGATACCCCGGCGACCATGGTCGAGCGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "885", "accession": "AM850921.2", "fmin": "24", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12359.2", "sequence": "MRYVRLCLISLIAALPLAVFASPQPLEQIKISEGQLAGRVGYVEMDLASGRMLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNTAGNLLLKIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTPATMVERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-19"}}, "1070": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"340": {"$update": {"dna_sequence": {"$update": {"accession": "JF969163.1"}}}}}}}}}, "$insert": {"CARD_short_name": "sul1"}}, "1071": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1554": {"$update": {"dna_sequence": {"$update": {"accession": "KM087856.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-22"}}, "1678": {"$update": {"ARO_description": "AAC(6')-Ib-cr is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Enterobacteriaceae. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously.", "model_name": "AAC(6')-Ib-cr1"}, "$insert": {"CARD_short_name": "AAC(6')-Ib-cr1"}}, "1679": {"$update": {"ARO_description": "OXA-49 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1766": {"$update": {"dna_sequence": {"$update": {"accession": "AY288523.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-49"}}, "1674": {"$update": {"ARO_description": "AAC(6')-It is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 16.", "model_sequences": {"$update": {"sequence": {"$update": {"736": {"$update": {"dna_sequence": {"$update": {"accession": "AF031328.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-It"}}, "1675": {"$update": {"ARO_description": "CTX-M-5 is a beta-lactamase found in Salmonella typhimurium.", "model_sequences": {"$update": {"sequence": {"$update": {"1087": {"$update": {"dna_sequence": {"$update": {"accession": "U95364.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-5"}}, "1676": {"$update": {"ARO_description": "GES-18 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1013": {"$update": {"dna_sequence": {"$update": {"accession": "JQ028729.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-18"}}, "1677": {"$update": {"ARO_description": "A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity.", "model_sequences": {"$update": {"sequence": {"$update": {"3285": {"$update": {"dna_sequence": {"$update": {"accession": "U05883.1"}}}}}}}}, "model_name": "cepA", "ARO_category": {"$update": {"41356": {"$update": {"category_aro_name": "CepA beta-lactamase", "category_aro_description": "CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin."}}}}}, "$insert": {"CARD_short_name": "cepA"}}, "1670": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "nalC"}}, "1671": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Sent_soxS_MULT"}}, "1672": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1159": {"$update": {"dna_sequence": {"$update": {"accession": "KF513179.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-211"}}, "1673": {"$update": {"ARO_description": "QnrA6 is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"3348": {"$update": {"dna_sequence": {"$update": {"accession": "DQ151889.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrA6"}}, "1094": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"862": {"$update": {"dna_sequence": {"$update": {"accession": "KJ934265.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-17"}}, "1095": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1791": {"$update": {"dna_sequence": {"$update": {"accession": "AY790341.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-59"}}, "1096": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"851": {"$update": {"dna_sequence": {"$update": {"accession": "AF190692.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-79"}}, "1097": {"$update": {"ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Erm(38)"}}, "1090": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1075": {"$update": {"dna_sequence": {"$update": {"accession": "FJ873740.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-169"}}, "1091": {"$update": {"ARO_description": "IMP-6 is a beta-lactamase found in Serratia marcescens.", "model_sequences": {"$update": {"sequence": {"$update": {"1278": {"$update": {"dna_sequence": {"$update": {"accession": "AB040994.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-6"}}, "1092": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"161": {"$update": {"dna_sequence": {"$update": {"accession": "AY743590.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(39)"}}, "1093": {"$update": {"ARO_description": "AAC(6')-31 is an integron-encoded aminoglycoside acetyltransferase in Pseudomonas putida, A. baumannii and K. pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"267": {"$update": {"dna_sequence": {"$update": {"accession": "AM283489.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-31"}}, "674": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1834": {"$update": {"dna_sequence": {"$update": {"accession": "U63835.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-15"}}, "675": {"$update": {"ARO_description": "OXA-25 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1210": {"$update": {"dna_sequence": {"$update": {"accession": "AF201826.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-25"}}, "676": {"$update": {"ARO_description": "AAC(6')-Ih is a plasmid-encoded aminoglycoside acetyltransferase in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"456": {"$update": {"dna_sequence": {"$update": {"accession": "L29044.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ih"}}, "677": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1755": {"$update": {"dna_sequence": {"$update": {"accession": "HM488992.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-171"}}, "4332": {"$insert": {"CARD_short_name": "ADC-54"}}, "4333": {"$insert": {"CARD_short_name": "ADC-57"}}, "672": {"$update": {"ARO_description": "CMY-27 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1442": {"$update": {"dna_sequence": {"$update": {"accession": "EU515250.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-27"}}, "673": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1111": {"$update": {"dna_sequence": {"$update": {"accession": "KM087857.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-48"}}, "3135": {"$insert": {"CARD_short_name": "MCR-1.9"}}, "3134": {"$insert": {"CARD_short_name": "MCR-1.10"}}, "3137": {"$update": {"ARO_description": "An MCR-3 polymyxin (incl. colistin) resistance gene variant identified from an Aeromonas isolate."}, "$insert": {"CARD_short_name": "MCR-3.8"}}, "3136": {"$update": {"ARO_description": "An MCR-3 polymyxin (incl. colistin) resistance gene variant isolated from an Aeromonas isolate."}, "$insert": {"CARD_short_name": "MCR-3.9"}}, "3131": {"$insert": {"CARD_short_name": "MCR-3.6"}}, "3130": {"$update": {"ARO_description": "An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in Great Britain."}, "$insert": {"CARD_short_name": "MCR-2.2"}}, "3133": {"$insert": {"CARD_short_name": "MCR-3.5"}}, "3132": {"$insert": {"CARD_short_name": "MCR-3.10"}}, "3139": {"$update": {"ARO_description": "An MCR-3 polymyxin resistance gene variant identified in a colistin-resistant Salmonella isolate from Canada, located on an IncHI-2 plasmid."}, "$insert": {"CARD_short_name": "MCR-3.2"}}, "3138": {"$update": {"ARO_description": "An MCR polymyxin (colistin) resistance gene variant identified in Aeromonas."}, "$insert": {"CARD_short_name": "MCR-3.7"}}, "1533": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-143"}}, "933": {"$update": {"ARO_description": "OKP-A-14 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1120": {"$update": {"dna_sequence": {"$update": {"accession": "FJ534512.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-14"}}, "1915": {"$update": {"model_sequences": {"$update": {"sequence": {"8248": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGAGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGTTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "fmax": "2185", "accession": "HM046998.2", "fmin": "1039", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Citrobacter freundii", "NCBI_taxonomy_id": "546", "NCBI_taxonomy_cvterm_id": "36915"}, "protein_sequence": {"accession": "ADH82410.1", "sequence": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ"}}}}}}, "$insert": {"CARD_short_name": "CMY-47"}}, "4443": {"$update": {"ARO_category": {"$update": {"41356": {"$update": {"category_aro_name": "CepA beta-lactamase", "category_aro_description": "CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin."}}}}}, "$insert": {"CARD_short_name": "CepA-44"}}, "4982": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-662"}}, "5183": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-886"}}, "1418": {"$update": {"ARO_description": "DHA-6 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1783": {"$update": {"dna_sequence": {"$update": {"accession": "HQ322612.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-6"}}, "1051": {"$update": {"ARO_description": "LEN-12 is a beta-lactamase found in Klebsiella pneumoniae.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-12"}}, "5192": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-896"}}, "5147": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-849"}}, "1410": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1681": {"$update": {"dna_sequence": {"$update": {"accession": "AF043381.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-19"}}, "1411": {"$update": {"ARO_description": "OXA-62 is a beta-lactamase found in Pandoraea pnomenusa.", "model_sequences": {"$update": {"sequence": {"$update": {"1537": {"$update": {"dna_sequence": {"$update": {"accession": "AY423074.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-62"}}, "1412": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1146": {"$update": {"dna_sequence": {"$update": {"accession": "AB733453.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-167"}}, "1413": {"$update": {"ARO_description": "OXA-172 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1835": {"$update": {"dna_sequence": {"$update": {"accession": "HM113558.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-172"}}, "1414": {"$update": {"ARO_description": "QnrB15 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"297": {"$update": {"dna_sequence": {"$update": {"accession": "EU302865.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB15"}}, "1415": {"$update": {"ARO_description": "AAC(2')-Id is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium smegmatis.", "model_sequences": {"$update": {"sequence": {"$update": {"228": {"$update": {"dna_sequence": {"$update": {"accession": "U72743.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(2')-Id"}}, "1416": {"$update": {"ARO_description": "OXA-89 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1139": {"$update": {"dna_sequence": {"$update": {"accession": "DQ445683.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-89"}}, "1417": {"$update": {"ARO_description": "OXA-131 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1678": {"$update": {"dna_sequence": {"$update": {"accession": "EU547446.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-131"}}, "1322": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1068": {"$update": {"dna_sequence": {"$update": {"accession": "DQ174305.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-65"}}, "1323": {"$update": {"ARO_description": "Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance."}, "$insert": {"CARD_short_name": "Sser_parE_FLO"}}, "1320": {"$update": {"ARO_description": "A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge."}, "$insert": {"CARD_short_name": "Kleb_PhoP_CST"}}, "1321": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"227": {"$update": {"dna_sequence": {"$update": {"accession": "KC243783.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mecA"}}, "1326": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1680": {"$update": {"dna_sequence": {"$update": {"accession": "HM488991.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-170"}}, "1327": {"$update": {"ARO_description": "AAC(6')-Iq is a aminoglycoside acetyltransferase encoded by plasmids and integrons in K. pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"343": {"$update": {"dna_sequence": {"$update": {"accession": "AF047556.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iq"}}, "1324": {"$update": {"ARO_description": "LRA-2 is a beta-lactamase isolated from soil samples in Alaska.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-2"}}, "1325": {"$update": {"ARO_description": "OXA-65 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1767": {"$update": {"dna_sequence": {"$update": {"accession": "AY750908.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-65"}}, "1328": {"$update": {"ARO_description": "Also known as vanSM, is a vanS variant found in the vanM gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"44": {"$update": {"dna_sequence": {"$update": {"accession": "FJ349556.1"}}}}}}}}, "model_name": "vanS gene in vanM cluster", "ARO_name": "vanS gene in vanM cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanM_cl"}}, "1329": {"$update": {"ARO_description": "ANT(4')-IIb is a transposon-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"234": {"$update": {"dna_sequence": {"$update": {"accession": "AY114142.1"}}}}}}}}, "ARO_category": {"$update": {"36368": {"$update": {"category_aro_description": "Nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 4'."}}}}}, "$insert": {"CARD_short_name": "ANT(4')-IIb"}}, "5180": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-883"}}, "4647": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7022": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-34"}}, "4208": {"$insert": {"CARD_short_name": "ADC-137"}}, "4209": {"$insert": {"CARD_short_name": "ADC-138"}}, "4202": {"$insert": {"CARD_short_name": "ADC-131"}}, "4203": {"$insert": {"CARD_short_name": "ADC-132"}}, "4200": {"$insert": {"CARD_short_name": "ADC-129"}}, "4201": {"$insert": {"CARD_short_name": "ADC-130"}}, "4206": {"$insert": {"CARD_short_name": "ADC-135"}}, "4207": {"$insert": {"CARD_short_name": "ADC-136"}}, "4204": {"$insert": {"CARD_short_name": "ADC-133"}}, "4205": {"$insert": {"CARD_short_name": "ADC-134"}}, "1531": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1080": {"$update": {"dna_sequence": {"$update": {"accession": "AF427127.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-81"}}, "5568": {"$insert": {"CARD_short_name": "PDC-440"}}, "5569": {"$insert": {"CARD_short_name": "PDC-441"}}, "4445": {"$insert": {"CARD_short_name": "CfiA10"}}, "5564": {"$insert": {"CARD_short_name": "PDC-435"}}, "5565": {"$insert": {"CARD_short_name": "PDC-436"}}, "5566": {"$insert": {"CARD_short_name": "PDC-437"}}, "5567": {"$insert": {"CARD_short_name": "PDC-439"}}, "5560": {"$insert": {"CARD_short_name": "PDC-431"}}, "1053": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1234": {"$update": {"dna_sequence": {"$update": {"accession": "AF148851.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-2"}}, "5562": {"$insert": {"CARD_short_name": "PDC-433"}}, "5563": {"$insert": {"CARD_short_name": "PDC-434"}}, "1524": {"$update": {"ARO_description": "cat-TC is a plasmid-encoded variant of the cat gene found in Limosilactobacillus reuteri.", "model_sequences": {"$update": {"sequence": {"$update": {"688": {"$update": {"dna_sequence": {"$update": {"accession": "U75299.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Limosilactobacillus reuteri"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}, "model_name": "Limosilactobacillus reuteri cat-TC", "ARO_name": "Limosilactobacillus reuteri cat-TC"}, "$insert": {"CARD_short_name": "Lreu_cat-TC"}}, "1257": {"$update": {"ARO_description": "QnrB68 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii.", "model_sequences": {"$update": {"sequence": {"$update": {"236": {"$update": {"dna_sequence": {"$update": {"accession": "KC580657.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB68"}}, "1254": {"$update": {"ARO_description": "CTX-M-46 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"768": {"$update": {"dna_sequence": {"$update": {"accession": "AY847147.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-46"}}, "1255": {"$update": {"ARO_description": "OXA-119 is a beta-lactamase found in Enterobacteriaceae.", "model_sequences": {"$update": {"sequence": {"$update": {"1043": {"$update": {"dna_sequence": {"$update": {"accession": "AY139598.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-119"}}, "1520": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1486": {"$update": {"dna_sequence": {"$update": {"accession": "DQ322460.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-85"}}, "1521": {"$update": {"model_sequences": {"$update": {"sequence": {"8290": {"dna_sequence": {"partial": "0", "sequence": "ATGTTAAAAGTTATTAGTAGTTTATTGGTCTACATGACCGCGTCTGTCATGGCTGTCGCAAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGACTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCGGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAAAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAGCGGGGAACGAGATTCCCACGCATTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCTGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAACGTGCTATACGGTGGTTGTGCCGTTCATGAGTTGTCAAGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCAAAGCACACAAAAATCGCTCAGTCGCCGAGTAG", "fmax": "2350", "accession": "JN676230.2", "fmin": "1549", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella oxytoca", "NCBI_taxonomy_id": "571", "NCBI_taxonomy_cvterm_id": "36788"}, "protein_sequence": {"accession": "AEZ49857.1", "sequence": "MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAAGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-32"}}, "1250": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"950": {"$update": {"dna_sequence": {"$update": {"accession": "AJ704396.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-96"}}, "1251": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1819": {"$update": {"dna_sequence": {"$update": {"accession": "KM211510.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-157"}}, "1528": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"999": {"$update": {"dna_sequence": {"$update": {"accession": "FJ919776.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-168"}}, "1529": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1880": {"$update": {"dna_sequence": {"$update": {"accession": "AJ866988.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-130"}}, "1258": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"979": {"$update": {"dna_sequence": {"$update": {"accession": "AY343493.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-55"}}, "1259": {"$update": {"model_sequences": {"$update": {"sequence": {"8197": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCAAACGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "927", "accession": "AY277255.2", "fmin": "66", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAP33454.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-31"}}, "308": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1265": {"$update": {"dna_sequence": {"$update": {"accession": "KM087838.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-118"}}, "309": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"782": {"$update": {"dna_sequence": {"$update": {"accession": "EF394371.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-35"}}, "3959": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 08-JUN-2016.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-1b-b"}}, "3958": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella penumoniae. Directly submitted to NCBI without publications on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-207"}}, "300": {"$update": {"ARO_description": "AAC(6')-29a is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa."}, "$insert": {"CARD_short_name": "AAC(6')-29a"}}, "5186": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-889"}}, "302": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"848": {"$update": {"dna_sequence": {"$update": {"accession": "KC818234.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-207"}}, "303": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"678": {"$update": {"dna_sequence": {"$update": {"accession": "L22689.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmQ"}}, "304": {"$update": {"ARO_description": "IND-11 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1747": {"$update": {"dna_sequence": {"$update": {"accession": "HM245379.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-11"}}, "305": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4490": {"$update": {"dna_sequence": {"$update": {"accession": "AY509120.1"}}}}}}}}, "ARO_category": {"$update": {"37697": {"$update": {"category_aro_description": "Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides."}}}}}, "$insert": {"CARD_short_name": "chrB"}}, "306": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1066": {"$update": {"dna_sequence": {"$update": {"accession": "AY037778.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-32"}}, "307": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"865": {"$update": {"dna_sequence": {"$update": {"accession": "HQ398214.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-101"}}, "4116": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-55 [Klebsiella pneumoniae] Accession: WP_168247883.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-49"}}, "1491": {"$update": {"ARO_description": "lnuF is an integron-mediated nucleotidyltransferase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8158": {"dna_sequence": {"partial": "0", "sequence": "ATGCTTCAGCAGAAAATGATCGAACGCTTCAAGGAAGCTTGCCATGAGGATGCACGAATAATCGCGGCGCTGATGTTCGGCTCATTTGCTATCGGAGAGGGTGACGAGTTCTCTGATATCGAATTTGCAGTGTTCATCCAGAATAATCATTTTGAAAATTTCGATCAGCGCTCGTGGCTTAATGCTGTAAGTCCGGTTGCAGCTTACTTTCCGGATGACTTCGGCCACCACACCGCGCTTTTTGAAAACGGCATTCGCGGTGAATTCCATTTCATGCGAAAATCGGACATACCGGTCATTTCCACTTGGCAAGGCTACGGGTGGTTTCCCTCGCTTGAGGAGGCTGTTTTGTTGGACCGATCAGGAGAGTTGTCAAGGTACGCGAGTGCTCTCGTGGGCAGTCCCCCGAAACGTGAAGGCGCGCCGCTGGTGGAAGGACTTGTATTGAACCTCATCAGCCTGATGCTCTTTGGGGCAAATCTTTTAAATCGGGGAGAGTATGCTCGCGCCTGGGCTTTGCTCAGCAAAGCACATGAAAACTTACTCAAGTTGGTTCGCCTCCATGAAGGGGCAACAGACCACTGGCCGACACCTTCACGCGCGCTCGAAAAGGATGTCTCGGAGGACTCGTATAATCGCTACCTGGCATGCACAGGCAGCGCGGAACCAAAAGCACTATGTGTAGCCTATCATGAAACGTGGAAGTGGAGTCTCGAATTGTTCAGGAGTGTGGCTGGACCTCTGAATATCGAGCTTCCGAGAATTGTAATTGCGCAGACAAAAAGGTTGCTAAATGAATCTGCGACGCCGCACAACAAGTAA", "fmax": "2142", "accession": "AJ561197.2", "fmin": "1320", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "CAD91132.1", "sequence": "MLQQKMIERFKEACHEDARIIAALMFGSFAIGEGDEFSDIEFAVFIQNNHFENFDQRSWLNAVSPVAAYFPDDFGHHTALFENGIRGEFHFMRKSDIPVISTWQGYGWFPSLEEAVLLDRSGELSRYASALVGSPPKREGAPLVEGLVLNLISLMLFGANLLNRGEYARAWALLSKAHENLLKLVRLHEGATDHWPTPSRALEKDVSEDSYNRYLACTGSAEPKALCVAYHETWKWSLELFRSVAGPLNIELPRIVIAQTKRLLNESATPHNK"}}}}}}, "$insert": {"CARD_short_name": "lnuF"}}, "2036": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"916": {"$update": {"dna_sequence": {"$update": {"accession": "JX121130.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-163"}}, "1792": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1414": {"$update": {"dna_sequence": {"$update": {"accession": "KM087848.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-20"}}, "4118": {"$update": {"ARO_description": "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-57 [Klebsiella pneumoniae] Accession: WP_171476789.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-57"}}, "2254": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3510": {"$update": {"dna_sequence": {"$update": {"accession": "BX571856.1"}}, "protein_sequence": {"$update": {"accession": "CAG39573.1"}}}}}}}}, "model_name": "Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid"}, "$insert": {"CARD_short_name": "Saur_fusA_FA"}}, "2858": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-79"}}, "5187": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-698"}}, "852": {"$update": {"ARO_description": "QnrB62 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"757": {"$update": {"dna_sequence": {"$update": {"accession": "JX987101.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB62"}}, "5184": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-701"}}, "4449": {"$insert": {"CARD_short_name": "CfiA18"}}, "4062": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6429": {"$update": {"dna_sequence": {"$update": {"accession": "NG_070786.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-931"}}, "4063": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6430": {"$update": {"dna_sequence": {"$update": {"accession": "NG_070785.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-930"}}, "4060": {"$update": {"model_sequences": {"$update": {"sequence": {"8136": {"dna_sequence": {"partial": "0", "sequence": "ATGATCATGTCGAAAAAATTAAAATGTCTGACGCTTTTTACAGCCATCTTTTTTGCAATTCCTATGGCTGCTTGTCAAAGTTTAAGCCAACAAAAGCAACAGCTCACGACAGAAAAAAATGATCAGCAGCAGATCTCAAGTTTATTCCAGAGCGCTCAAACCAGTGGTGTTTTGGTGATTTATGACGGCAAGAAAATTCAAAGCTATGGCAATGCGCTTGATCGTGCAGAGCAGCGTTATATTCCCGCCTCAACCTTTAAAATGTTGAATGCTTTGATCGGGATACAACATCATAAGACTGCACCAAATGAAGTGTTTAAATGGGATGGAAAAAAGCGAGCATTTAGTAGCTGGGAAAAAGATTTAACCTTAGCTGAAGCGATGCAGGCATCGGCGGTACCCGTTTATCAAGAGTTGGCAAGACGGATTGGTTTAGAACTGATGACCCGTGAAGTGAAGCGTGTAGGTTATGGTAATAAAAATATTGGGACGCAAGTGGATAATTTCTGGTTAGTTGGTCCCTTAAAAATCACTCCCGTAGAGGAAGTTCGCTTTGCCTATGCATTAGCAAAACAGAAATTACCCTTTGATCAGCCGACACAGCAACAAGTCAAAGCGATGTTATTGGTGGATCAGATCCAGGATACCAAAATCTATGCCAAAAGCGGTTGGGGAATGGATGTCAGCCCGCAAGTGGGTTGGTGGACGGGGTGGATTGAACAGCCAAATGGTAAGGTCATTGCATTCTCATTGAATATGCAAATGAGCCAGCCTGAACATGCAGATGCACGTAAAGCGATTGTGTATCAAGCCTTGCAACAGTTGGGATTGTTAGCCACTTAA", "fmax": "943", "accession": "NG_062218.2", "fmin": "100", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter gyllenbergii", "NCBI_taxonomy_id": "134534", "NCBI_taxonomy_cvterm_id": "42559"}, "protein_sequence": {"accession": "WP_081401608.1", "sequence": "MIMSKKLKCLTLFTAIFFAIPMAACQSLSQQKQQLTTEKNDQQQISSLFQSAQTSGVLVIYDGKKIQSYGNALDRAEQRYIPASTFKMLNALIGIQHHKTAPNEVFKWDGKKRAFSSWEKDLTLAEAMQASAVPVYQELARRIGLELMTREVKRVGYGNKNIGTQVDNFWLVGPLKITPVEEVRFAYALAKQKLPFDQPTQQQVKAMLLVDQIQDTKIYAKSGWGMDVSPQVGWWTGWIEQPNGKVIAFSLNMQMSQPEHADARKAIVYQALQQLGLLAT"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-673"}}, "4066": {"$update": {"model_sequences": {"$update": {"sequence": {"8362": {"dna_sequence": {"partial": "0", "sequence": "ATGCACAAACCAACCCCATTAAAACGGTTGTCGATGATACTTGCTCGTGACCTTAATGGTGCCATTGGTTACGAAGGTTCTTTGGCCATTAAATCGGACAATGATTTTGCGTGGTATAAGAAAATTACCAAACCATTTAAGCACGCTGTTTGTGGGCGAGTAACCTATGAGGAAGATTTGCCCGATATCGTCAAAAAACGCCACAGATTCATCATTATTACCCGTAATCCAGACAAGTACGCTAGTACTCCTGAAGCACAGTATATGACGCTCTCAGACGCGTTAAAAGAGTTACAAGTTTGGGACGTACCTGGTCACGACATTATCTGCTTAGGTGGTGCTGAAATTTACAAGGCATTATTGCCTTACGTTAGTACTGTTTACCTGACTACATTCTTTTCAGTAGCAGATGAAGCAGATACTTATTTCAATGACTTTACAGATAAATGGGAATCAGTAGGGGCCACTTGGTTTAACGACTGCTACTGCACCCGTCTGGAGCGTGTATGTCAATCTACAAACAATATTATCTAA", "fmax": "8262", "accession": "HQ386845.2", "fmin": "7728", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Gammaproteobacteria", "NCBI_taxonomy_id": "1236", "NCBI_taxonomy_cvterm_id": "40536"}, "protein_sequence": {"accession": "WP_045475347.1", "sequence": "MHKPTPLKRLSMILARDLNGAIGYEGSLAIKSDNDFAWYKKITKPFKHAVCGRVTYEEDLPDIVKKRHRFIIITRNPDKYASTPEAQYMTLSDALKELQVWDVPGHDIICLGGAEIYKALLPYVSTVYLTTFFSVADEADTYFNDFTDKWESVGATWFNDCYCTRLERVCQSTNNII"}}}}}}, "$insert": {"CARD_short_name": "DfrA42_TMP"}}, "4067": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6440": {"$update": {"dna_sequence": {"$update": {"accession": "NG_050781.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-567"}}, "5038": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7413": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-728"}}, "5361": {"$insert": {"CARD_short_name": "PDC-221"}}, "5157": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-860"}}, "4638": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7013": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-25"}}, "5366": {"$insert": {"CARD_short_name": "PDC-227"}}, "2478": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"12459": "A926G", "12458": "A928C"}}, "clinical": {"$insert": {"12459": "A926G", "12458": "A928C"}}}}, "40330": {"$update": {"param_value": {"$insert": {"12555": "A926T,G927T,A928C", "12556": "A926G,G927G,A928C"}}}}}}}, "$insert": {"CARD_short_name": "Hpyl_16S_TET"}}, "623": {"$update": {"ARO_description": "OXA-68 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"2014": {"$update": {"dna_sequence": {"$update": {"accession": "AY750910.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-68"}}, "4945": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-619"}}, "1563": {"$update": {"ARO_description": "CTX-M-63 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"868": {"$update": {"dna_sequence": {"$update": {"accession": "AB205197.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-63"}}, "993": {"$update": {"ARO_description": "AAC(6')-Ib9 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"463": {"$update": {"dna_sequence": {"$update": {"accession": "AF043381.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ib9"}}, "5364": {"$insert": {"CARD_short_name": "PDC-224"}}, "5365": {"$insert": {"CARD_short_name": "PDC-226"}}, "5039": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-729"}}, "2035": {"$update": {"ARO_description": "CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1430": {"$update": {"dna_sequence": {"$update": {"accession": "AY044436.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CTX-M-15"}}, "2358": {"$insert": {"CARD_short_name": "ADC-42"}}, "2359": {"$insert": {"CARD_short_name": "ADC-43"}}, "2352": {"$insert": {"CARD_short_name": "ADC-22"}}, "2353": {"$insert": {"CARD_short_name": "ADC-23"}}, "2350": {"$insert": {"CARD_short_name": "ADC-20"}}, "2351": {"$insert": {"CARD_short_name": "ADC-21"}}, "622": {"$update": {"ARO_description": "DHA-7 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1865": {"$update": {"dna_sequence": {"$update": {"accession": "HQ456945.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-7"}}, "2357": {"$insert": {"CARD_short_name": "ADC-41"}}, "2354": {"$insert": {"CARD_short_name": "ADC-25"}}, "2355": {"$insert": {"CARD_short_name": "ADC-31"}}, "5369": {"$insert": {"CARD_short_name": "PDC-230"}}, "4624": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-41"}}, "4453": {"$insert": {"CARD_short_name": "CfiA22"}}, "4452": {"$insert": {"CARD_short_name": "CfiA21"}}, "4451": {"$insert": {"CARD_short_name": "CfiA2"}}, "4450": {"$insert": {"CARD_short_name": "CfiA19"}}, "1898": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1764": {"$update": {"dna_sequence": {"$update": {"accession": "KF986260.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-379"}}, "4456": {"$insert": {"CARD_short_name": "CfiA26"}}, "4455": {"$insert": {"CARD_short_name": "CfiA24"}}, "4454": {"$insert": {"CARD_short_name": "CfiA23"}}, "1894": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Sent_ramR"}}, "1895": {"$update": {"ARO_description": "CfxA3 beta-lactamase is a class A beta-lactamase found in Capnocytophaga ochracea.", "model_sequences": {"$update": {"sequence": {"8285": {"dna_sequence": {"partial": "0", "sequence": "ATGGAAAAAAACAGAAAAAAACAAATCGTAGTTTTGAGTATAGCTTTAGTTTGCATTTTCATCTTGGTATTTTCATTGTTCCATAAATCAGCGACAAAAGATAGCGCAAATCCTCCTTTAACAAATGTTTTGACTGATAGCATTTCTCAAATTGTCTCAGCTTGTCCTGGCGAAATTGGTGTGGCGGTTATTGTTAATAACAGAGATACGGTTAAGGTCAATAATAAGAGTGTTTATCCTATGATGAGTGTGTTTAAGGTTCATCAGGCATTAGCTCTTTGTAATGACTTTGACAATAAAGGAATTTCACTTGATACCTTAGTAAATATAAATAGGGATAAACTTGACCCAAAGACTTGGAGTCCTATGCTGAAAGATTATTCAGGGCCAGTCATATCATTGACAGTGAGAGATTTGCTGCGTTATACTCTTACTCAGAGTGACAACAATGCAAGCAACCTTATGTTTAAGGATATGGTTAATGTCGCTCAAACAGATAGTTTTATAGCCACACTCATTCCTCGTTCAAGTTTTCAGATAGCTTATACGGAAGAGGAAATGTCGGCTGACCATAACAAGGCTTACTCTAACTATACATCTCCTCTTGGTGCTGCAATGTTGATGAATCGTTTGTTTACTGAAGGTCTTATCGATGATGAGAAACAAAGTTTCATTAAGAATACGTTAAAAGAATGCAAAACAGGTGTAGATAGGATAGCAGCTCCACTTCTTGATAAAGAAGGGGTTGTTATAGCGCATAAGACAGGTTCAGGTGATGTTAATGAAAATGGTGTTCTTGCAGCTCACAATGATGTTGCCTATATATGTCTGCCTAATAATATCAGTTATACCTTAGCGGTATTTGTTAAGGATTTCAAGGGAAATGAATCACAAGCGTCACAATATGTTGCGCATATATCAGCTGTAGTATATTCTTTATTAATGCAAACTTCAGTAAAATCTTAA", "fmax": "1018", "accession": "AF472622.2", "fmin": "52", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Capnocytophaga ochracea", "NCBI_taxonomy_id": "1018", "NCBI_taxonomy_cvterm_id": "36958"}, "protein_sequence": {"accession": "AAL79549.2", "sequence": "MEKNRKKQIVVLSIALVCIFILVFSLFHKSATKDSANPPLTNVLTDSISQIVSACPGEIGVAVIVNNRDTVKVNNKSVYPMMSVFKVHQALALCNDFDNKGISLDTLVNINRDKLDPKTWSPMLKDYSGPVISLTVRDLLRYTLTQSDNNASNLMFKDMVNVAQTDSFIATLIPRSSFQIAYTEEEMSADHNKAYSNYTSPLGAAMLMNRLFTEGLIDDEKQSFIKNTLKECKTGVDRIAAPLLDKEGVVIAHKTGSGDVNENGVLAAHNDVAYICLPNNISYTLAVFVKDFKGNESQASQYVAHISAVVYSLLMQTSVKS"}}}}}, "ARO_category": {"$update": {"39434": {"$update": {"category_aro_description": "CfxA beta-lactamases are class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "CfxA3"}}, "4459": {"$insert": {"CARD_short_name": "CfiA8"}}, "4458": {"$insert": {"CARD_short_name": "CfiA4"}}, "1890": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1497": {"$update": {"dna_sequence": {"$update": {"accession": "AJ277415.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-86"}}, "1891": {"$update": {"ARO_description": "AAC(6')-Iih is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus hirae.", "model_sequences": {"$update": {"sequence": {"8279": {"dna_sequence": {"partial": "0", "sequence": "ATGATTATCAGTGAGTTTGATCGTGATAATTTGGTTTTACGTGACCAATTAGCCGATCTTTTGAGATTGACTTGGCCAGATGAATACGGTGAACAGCCGATGAAAGAAGTAGAGCGACTGCTGGAAGATGAAAGGATCGCCGTCTCTGCAATCGAAGGAGATGAGCTGATTGGTTTTGTCGGTGCGATTCCACAATATGGTCAAACTGGTTGGGAACTGCATCCCTTAGTCGTCGAAAGTATGTACCGTAAGCAACAAGTTGGTACACGCCTAGTGAGTTATCTAGAAAAAGAGATTGCCTCACAAGGAGGAATCGTTGTCTATTTAGGAACTGATGATGTGGAAGGGCAAACAAGCTTGGCGATTGAAGAAGACCTGTTTGAAGATACCTTTGACAAGCTTGAAACGATTCAAAACAGGAAAGATCATCCTTATGAATTCTATGAGAAACTTGGCTATCAGATCGTTGGGGTAATTCCGGATGCGAATGGCTGGAACAAGCCAGATATTTGGATGGCCAAACGAATTGCTAGAAAACATGGAAGTGAATGA", "fmax": "562", "accession": "AJ584701.2", "fmin": "10", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus durans", "NCBI_taxonomy_id": "53345", "NCBI_taxonomy_cvterm_id": "39522"}, "protein_sequence": {"accession": "CAE50926.1", "sequence": "MIISEFDRDNLVLRDQLADLLRLTWPDEYGEQPMKEVERLLEDERIAVSAIEGDELIGFVGAIPQYGQTGWELHPLVVESMYRKQQVGTRLVSYLEKEIASQGGIVVYLGTDDVEGQTSLAIEEDLFEDTFDKLETIQNRKDHPYEFYEKLGYQIVGVIPDANGWNKPDIWMAKRIARKHGSE"}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iih"}}, "1892": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1921": {"$update": {"dna_sequence": {"$update": {"accession": "EU188842.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114a"}}, "1893": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"828": {"$update": {"dna_sequence": {"$update": {"accession": "GQ390809.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-127"}}, "2136": {"$update": {"ARO_description": "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to kanamycin A.", "model_sequences": {"$update": {"sequence": {"$update": {"3232": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-63"}}, "4921": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-595"}}, "4920": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-594"}}, "2132": {"$insert": {"CARD_short_name": "Mtub_16S_KAN"}}, "4926": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-600"}}, "2130": {"$insert": {"CARD_short_name": "opcM"}}, "2131": {"$insert": {"CARD_short_name": "Mtub_16S_STR"}}, "951": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1262": {"$update": {"dna_sequence": {"$update": {"accession": "JX440356.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-15"}}, "950": {"$update": {"ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmX"}}, "953": {"$insert": {"CARD_short_name": "Efae_liaF_DAP"}}, "4928": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-602"}}, "955": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"841": {"$update": {"dna_sequence": {"$update": {"accession": "EF373971.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-96"}}, "954": {"$update": {"ARO_description": "APH(3')-IIb is a chromosomal-encoded aminoglycoside phosphotransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"159": {"$update": {"dna_sequence": {"$update": {"accession": "X90856.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-IIb"}}, "2138": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3362": {"$update": {"dna_sequence": {"$update": {"accession": "Z21956.1"}}}}}}}}, "model_name": "NmcA", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NmcA"}}, "956": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1652": {"$update": {"dna_sequence": {"$update": {"accession": "AY027590.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-88"}}, "949": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1904": {"$update": {"dna_sequence": {"$update": {"accession": "AM982521.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-77"}}, "1442": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mdtN"}}, "1967": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6248": {"$update": {"dna_sequence": {"$update": {"accession": "EU220744.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-185"}}, "3422": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-157"}}, "3420": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-156"}}, "3427": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-260"}}, "3426": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-259"}}, "3425": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-252"}}, "3424": {"$update": {"ARO_description": "OXA-234 is a beta-lactamase found in Acinetobacter baumannii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-234"}}, "2002": {"$update": {"ARO_description": "cat86 is a chromosome-encoded variant of the cat gene found in Bacillus pumilus.", "model_sequences": {"$update": {"sequence": {"$update": {"143": {"$update": {"dna_sequence": {"$update": {"accession": "K00544.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-24"}}, "2001": {"$update": {"ARO_description": "OXA-250 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1297": {"$update": {"dna_sequence": {"$update": {"accession": "HE963771.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-520"}}, "2009": {"$update": {"ARO_description": "aadA6 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"199": {"$update": {"dna_sequence": {"$update": {"accession": "AM087411.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA6"}}, "4581": {"$insert": {"CARD_short_name": "DHA-28"}}, "4580": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6955": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-27"}}, "4583": {"$insert": {"CARD_short_name": "DHA-4"}}, "4582": {"$insert": {"CARD_short_name": "DHA-29"}}, "4414": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-28"}}, "2034": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1320": {"$update": {"dna_sequence": {"$update": {"accession": "AF506748.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-108"}}, "4413": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-27"}}, "4301": {"$insert": {"CARD_short_name": "ADC-236"}}, "1855": {"$update": {"ARO_description": "CTX-M-72 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1591": {"$update": {"dna_sequence": {"$update": {"accession": "AY847148.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-72"}}, "2152": {"$update": {"ARO_description": "Point mutations in the 16S rRNA of Neisseria meningitidis can confer resistance to spectinomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"4137": {"$update": {"dna_sequence": {"$update": {"accession": "NC_003112.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Nmen_16S_SPT"}}, "2852": {"$insert": {"CARD_short_name": "PDC-73"}}, "4300": {"$insert": {"CARD_short_name": "ADC-235"}}, "4411": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-25"}}, "4577": {"$insert": {"CARD_short_name": "DHA-24"}}, "4410": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-24"}}, "4825": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-193"}}, "3557": {"$update": {"ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-23"}}, "5411": {"$insert": {"CARD_short_name": "PDC-277"}}, "3555": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "AST-1"}}, "3554": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ARL-6"}}, "3553": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ARL-5"}}, "3552": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ARL-4"}}, "3551": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ARL-3"}}, "3550": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ARL-2"}}, "3950": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-226"}}, "3559": {"$update": {"ARO_description": "BCL-1 is a class A beta-lactamase found in Alkalihalobacillus clausii.", "model_sequences": {"$update": {"sequence": {"$update": {"5754": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Alkalihalobacillus clausii"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BCL-1"}}, "3558": {"$insert": {"CARD_short_name": "BAT-1"}}, "624": {"$update": {"ARO_description": "Point mutations that occurs in Mycobacterium leprae rpoB resulting in resistance to rifampicin.", "model_sequences": {"$update": {"sequence": {"$update": {"4581": {"$update": {"dna_sequence": {"$update": {"accession": "AL450380.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Mlep_rpoB_RIF"}}, "1263": {"$update": {"ARO_description": "QnrB56 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"425": {"$update": {"dna_sequence": {"$update": {"accession": "JX259317.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB56"}}, "666": {"$update": {"ARO_description": "CTX-M-34 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1028": {"$update": {"dna_sequence": {"$update": {"accession": "AY515297.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-34"}}, "2176": {"$update": {"ARO_description": "Homologous to vanC, contains a D-Ala-D-Ser ligase. The plasmid-located vanM gene cluster is inducible and confers low resistance to vancomycin. vanN organisms remain susceptible to teicoplanin. Gene orientation: N(XY)TRS."}, "$insert": {"CARD_short_name": "vanN_cluster"}}, "504": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1802": {"$update": {"dna_sequence": {"$update": {"accession": "Y13612.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-52"}}, "665": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2029": {"$update": {"dna_sequence": {"$update": {"accession": "AF093512.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-10"}}, "4944": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-618"}}, "2177": {"$update": {"ARO_description": "This inducible cluster confers high resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. The vanA gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSHAXYZ."}, "$insert": {"CARD_short_name": "vanA_cluster"}}, "2910": {"$update": {"ARO_description": "Beta-lactamase found in Acinetobacter rudis efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-665"}}, "1799": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1881": {"$update": {"dna_sequence": {"$update": {"accession": "DQ279850.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-147"}}, "2913": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5902": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Acinetobacter proteolyticus"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-286"}}, "2914": {"$update": {"model_name": "Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin"}, "$insert": {"CARD_short_name": "Bado_rpoB_RIF"}}, "719": {"$update": {"ARO_description": "CMY-33 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1914": {"$update": {"dna_sequence": {"$update": {"accession": "EU496816.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-33"}}, "718": {"$update": {"ARO_description": "LRA-8 is a beta-lactamase isolated from soil samples in Alaska.", "model_sequences": {"$update": {"sequence": {"$update": {"858": {"$update": {"dna_sequence": {"$update": {"accession": "EU408349.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-8"}}, "717": {"$update": {"ARO_description": "CTX-M-100 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"784": {"$update": {"dna_sequence": {"$update": {"accession": "FR682582.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-100"}}, "1267": {"$update": {"ARO_description": "QnrB40 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii.", "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB40"}}, "715": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1541": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666066.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PDC-3"}}, "714": {"$insert": {"CARD_short_name": "dfrB1"}}, "713": {"$update": {"ARO_description": "CTX-M-81 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8133": {"dna_sequence": {"partial": "0", "sequence": "ATGGTGACAAAGAGAGTGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTGCTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCGCAGATAATACGCAGGTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTGAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCCAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACCATGACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACCATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGTGGGTGATAAGACCGGCAGCGGCGACTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTGGTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTGGCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA", "fmax": "876", "accession": "EU136031.3", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "ABV57756.3", "sequence": "MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLEQSETQKQLLNQPVEIQPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDHTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-81"}}, "712": {"$update": {"ARO_description": "catB2 is a plasmid-encoded variant of the cat gene found in Escherichia coli, Salmonella enteritidis and Pasteurella multocida.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catB2"}}, "711": {"$update": {"model_sequences": {"$update": {"sequence": {"8207": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAATACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCAGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AJ866285.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAI30651.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKYLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-62"}}, "710": {"$update": {"ARO_description": "dfrB6 is an integron-encoded dihydrofolate reductase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"430": {"$update": {"dna_sequence": {"$update": {"accession": "GU060319.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrB6"}}, "4967": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-642"}}, "661": {"$update": {"ARO_description": "VIM-5 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"855": {"$update": {"dna_sequence": {"$update": {"accession": "AY144612.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-5"}}, "716": {"$update": {"ARO_description": "QnrB32 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"405": {"$update": {"dna_sequence": {"$update": {"accession": "JN173054.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB32"}}, "4966": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-640"}}, "505": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2100": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}, "ARO_category": {"$update": {"40043": {"$update": {"category_aro_description": "Mutations that occurs on the iniC genes resulting in the resistance to ethambutol."}}}}}, "$insert": {"CARD_short_name": "Mtub_iniC_EMB"}}, "5260": {"$insert": {"CARD_short_name": "PDC-124"}}, "4965": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-639"}}, "1906": {"$update": {"ARO_description": "CTX-M-17 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"907": {"$update": {"dna_sequence": {"$update": {"accession": "AY033516.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-17"}}, "4078": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6451": {"$update": {"dna_sequence": {"$update": {"accession": "NG_062229.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DfrA34"}}, "1069": {"$update": {"ARO_description": "IMP-35 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1556": {"$update": {"dna_sequence": {"$update": {"accession": "JF816544.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-35"}}, "1068": {"$update": {"ARO_description": "AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"141": {"$update": {"dna_sequence": {"$update": {"accession": "FJ854362.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ib3"}}, "916": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1842": {"$update": {"dna_sequence": {"$update": {"accession": "AF300985.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-36"}}, "1061": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1140": {"$update": {"dna_sequence": {"$update": {"accession": "FJ785626.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-10"}}, "1060": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1772": {"$update": {"dna_sequence": {"$update": {"accession": "EU032604.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-103"}}, "1063": {"$update": {"ARO_description": "QnrB73 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"513": {"$update": {"dna_sequence": {"$update": {"accession": "KF443075.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB73"}}, "1062": {"$update": {"model_sequences": {"$update": {"sequence": {"8237": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAATACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGTAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM176546.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47126.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKYLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-71"}}, "1065": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-384"}}, "1064": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1027": {"$update": {"dna_sequence": {"$update": {"accession": "KC964871.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-141"}}, "1067": {"$insert": {"CARD_short_name": "MexE"}}, "1066": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5899": {"$update": {"dna_sequence": {"$update": {"accession": "AY130285.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-118"}}, "4961": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-635"}}, "1669": {"$update": {"ARO_description": "Also known as vanZF, is a vanZ variant found in the vanF gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"566": {"$update": {"dna_sequence": {"$update": {"accession": "AF155139.1"}}}}}}}}, "model_name": "vanZ gene in vanF cluster", "ARO_name": "vanZ gene in vanF cluster"}, "$insert": {"CARD_short_name": "vanZ_in_vanF_cl"}}, "1668": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"945": {"$update": {"dna_sequence": {"$update": {"accession": "JN714480.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-68"}}, "1667": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1003": {"$update": {"dna_sequence": {"$update": {"accession": "AF347054.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-80"}}, "1666": {"$update": {"ARO_description": "Also known as vanXB, is a vanX variant found in the vanB gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3456": {"$update": {"dna_sequence": {"$update": {"accession": "U35369.1"}}}}}}}}, "model_name": "vanX gene in vanB cluster", "ARO_name": "vanX gene in vanB cluster"}, "$insert": {"CARD_short_name": "vanX_in_vanB_cl"}}, "1665": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"289": {"$update": {"dna_sequence": {"$update": {"accession": "JQ727668.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "ramA"}}, "1664": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"674": {"$update": {"dna_sequence": {"$update": {"accession": "AY769962.1"}}}}}}}}}, "$insert": {"CARD_short_name": "adeK"}}, "1663": {"$update": {"ARO_description": "ACC-1 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"856": {"$update": {"dna_sequence": {"$update": {"accession": "AJ133121.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-1"}}, "1662": {"$update": {"ARO_description": "OKP-B-17 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8271": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAGGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGCTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGTGATACCCCGGCGACCATGGTCGAGCGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAA", "fmax": "885", "accession": "AM850919.2", "fmin": "24", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12357.2", "sequence": "MRYVRLCLISLIAALPLAVFASPQPLEQIKISEGQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTPATMVERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-17"}}, "4435": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-51"}}, "1660": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-375"}}, "1087": {"$update": {"ARO_description": "OXA-253 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"8256": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAAATTTATACTTCCTATCTTCAGCATTTCTATTCTACTTTCTCTCAGTGCATGCTCATCTATTCAAACTAAATTTGAAGATACTTCTGATATTTCTGATCAGCAACAAGGAAAAGCCATTAAAAGCTATTTTGATGAAGCTCAAACACAAGGTGTAATCATTATTAAAGAGGGAAAGAATATTAGTACCTATGGTAATAACCTGGCACGAGCACATACAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCCTTAATTGGATTAGAAAATCATAAAGCTACAACAACTGAGATTTTCAAATGGGATGGTAAAAAAAGATCTTATCCTATGTGGGAAAAAGATATGACTTTAGGTGATGCCATGGCACTTTCAGCAGTTCCTGTATATCAAGAACTTGCAAGACGGACTGGTTTAGACCTAATGCAAAAAGAAGTCAAACGGGTTGGTTTTGGTAATATGAACATTGGAACACAAGTTGATAACTTCTGGTTGGTTGGCCCGCTTAAAATTACACCAATACAAGAGGTTAATTTTGCCGACGATCTCGCTAATAATCGATTACCCTTTAAATTAGAAACTCAAGAAGAAGTAAAAAAAATGCTTCTGATTAAAGAAGTCAATGGTAGTAAAATTTATGCGAAAAGCGGATGGGGAATGGATGTAATCCCTCAGGTAGGTTGGTTAACAGGTTGGGTAGAAAAATCTAATGGCGAAAAAGTTCCCTTTTCTCTAAACCTAGAAATGAAGCAAGGAATGTCTGGTTCTATTCGTAATGAAATTACTTATAAGTCATTAGAAAATTTAGGGATTATATAG", "fmax": "1403", "accession": "KC479324.2", "fmin": "575", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "AGK07368.1", "sequence": "MKKFILPIFSISILLSLSACSSIQTKFEDTSDISDQQQGKAIKSYFDEAQTQGVIIIKEGKNISTYGNNLARAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEKDMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMNIGTQVDNFWLVGPLKITPIQEVNFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVIPQVGWLTGWVEKSNGEKVPFSLNLEMKQGMSGSIRNEITYKSLENLGII"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-253"}}, "1086": {"$update": {"ARO_description": "CMY-41 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1345": {"$update": {"dna_sequence": {"$update": {"accession": "AB429270.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-41"}}, "593": {"$insert": {"CARD_short_name": "abeS"}}, "592": {"$update": {"ARO_description": "lmrB is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Bacillus subtilis."}, "$insert": {"CARD_short_name": "lmrB"}}, "595": {"$update": {"model_sequences": {"$update": {"sequence": {"8231": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGCATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "891", "accession": "AM176550.2", "fmin": "30", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47130.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPHNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-75"}}, "594": {"$update": {"ARO_description": "QnrB41 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"645": {"$update": {"dna_sequence": {"$update": {"accession": "JN166690.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB41"}}, "597": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Kpne_ramR"}}, "596": {"$update": {"ARO_description": "ROB-1 is a beta-lactamase found in Pasteurella and Haemophilus.", "model_sequences": {"$update": {"sequence": {"$update": {"1386": {"$update": {"dna_sequence": {"$update": {"accession": "X52872.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ROB-1"}}, "599": {"$update": {"ARO_description": "OKP-A-3 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1447": {"$update": {"dna_sequence": {"$update": {"accession": "AM051140.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-3"}}, "598": {"$update": {"ARO_description": "dfrA16 is an integron-encoded dihydrofolate reductase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"8224": {"dna_sequence": {"partial": "0", "sequence": "GTGAAGTTATCACTAATGGCTGCCAAGTCGAAGAACGGTATTATCGGTAATGGACCAGATATTCCATGGAGCGCCAAAGGCGAGCAACTTCTATTTAAGGCAATTACATATAATCAATGGCTTTTAGTTGGACGCAAAACTTTTGAGTCAATGGGCGCTCTCCCAAATCGAAAGTATGCAGTTGTAACTCGCTCTAATTTTTCTACGAATGATGAGGGTGTAATGGTTTTCTCCTCAATTCAGGATGCCTTAATAAATTTAGAGGAAATCACGGATCATGTTATCGTTTCTGGTGGTGGTGAAATATACAAAAGCTTGATTTCCAAAGTAGATACTTTGCATATTTCAACAGTCGACATCGAGCGAGATGGAGACATAGTTTTTCCTGAAATCCCAGATACATTCAAGTTGGTATTTGAGCAAGATTTCGAGTCTAACATTAACTATTGTTATCAAATCTGGCAAAAGAGTTAA", "fmax": "1825", "accession": "AF174129.3", "fmin": "1351", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAK60186.1", "sequence": "MKLSLMAAKSKNGIIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSNFSTNDEGVMVFSSIQDALINLEEITDHVIVSGGGEIYKSLISKVDTLHISTVDIERDGDIVFPEIPDTFKLVFEQDFESNINYCYQIWQKS"}}}}}}, "$insert": {"CARD_short_name": "dfrA16"}}, "4322": {"$insert": {"CARD_short_name": "ADC-256"}}, "4325": {"$insert": {"CARD_short_name": "ADC-32"}}, "4324": {"$insert": {"CARD_short_name": "ADC-29"}}, "1089": {"$update": {"ARO_description": "CMY-14 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"8235": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGATAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "fmax": "1146", "accession": "AJ555825.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Proteus mirabilis", "NCBI_taxonomy_id": "584", "NCBI_taxonomy_cvterm_id": "36771"}, "protein_sequence": {"accession": "CAD88479.1", "sequence": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEINPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ"}}}}}}, "$insert": {"CARD_short_name": "CMY-14"}}, "1088": {"$update": {"ARO_description": "Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to daptomycin."}, "$insert": {"CARD_short_name": "Saur_rpoB_DAP"}}, "3141": {"$insert": {"CARD_short_name": "MCR-1.6"}}, "3142": {"$update": {"ARO_description": "An MCR-1 polymyxin resistance gene variant identified from a poultry Raoultella planticola isolate."}, "$insert": {"CARD_short_name": "MCR-1.3"}}, "3143": {"$insert": {"CARD_short_name": "MCR-1.4"}}, "2828": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mecD"}}, "3145": {"$update": {"ARO_description": "A novel plasmid-mediated colistin-resistant phosphoethanolamine transferase identified from a poultry isolate of Klebsiella pneumoniae."}, "$insert": {"CARD_short_name": "MCR-7.1"}}, "5307": {"$insert": {"CARD_short_name": "PDC-168"}}, "1526": {"$update": {"ARO_description": "AAC(6')-Iaa is a chromosomal-encoded aminoglycoside acetyltransferase in S. typhimurium."}, "$insert": {"CARD_short_name": "AAC(6')-Iaa"}}, "2824": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Mycoplasma pneumoniae shown to confer resistance to erythromycin."}, "$insert": {"CARD_short_name": "Mpne_23S_ERY"}}, "2825": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Halobacterium halobium shown to confer resistance to chloramphenicol.", "ARO_category": {"$update": {"41350": {"$update": {"category_aro_description": "Point mutations in the 23S rRNA subunit shown clinically to confer resistance to phenicol class antibiotics, including chloramphenicol and florfenicol, by disrupting antibiotic binding-site affinity."}}}}}, "$insert": {"CARD_short_name": "Hhal_23S_CHL"}}, "2826": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolides and streptogramins types of antibiotics.", "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Spne_23S_MULT"}}, "2827": {"$update": {"ARO_category": {"$update": {"40948": {"$update": {"category_aro_name": "Para-aminosalicylic acid", "category_aro_description": "Para-aminosalicylic acid (PAS) is an anti-tubercular antibiotic agent, often used in conjunction with Isoniazid for treatment of M. tuberculosis infections. PAS diminishes bacterial cell growth by limiting folic acid production."}}}}}, "$insert": {"CARD_short_name": "Mtub_ribD_PAS"}}, "2820": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Chlamydia trachomatis shown to confer resistance to macrolide type antibiotics."}, "$insert": {"CARD_short_name": "Ctra_23S_MAC"}}, "2033": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mtrR"}}, "2822": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Mycoplasma hominis shown to confer resistance to macrolide type antibiotics.", "model_name": "Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics"}, "$insert": {"CARD_short_name": "Mhom_23S_MAC"}}, "2823": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Mycoplasmopsis fermentans shown to confer resistance to macrolide type antibiotics.", "model_sequences": {"$update": {"sequence": {"$update": {"4167": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Mycoplasmopsis fermentans PG18"}}}}}}}}, "model_name": "Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics", "ARO_name": "Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics"}, "$insert": {"CARD_short_name": "Mfer_23S_MAC"}}, "5414": {"$insert": {"CARD_short_name": "PDC-280"}}, "5415": {"$insert": {"CARD_short_name": "PDC-281"}}, "5416": {"$insert": {"CARD_short_name": "PDC-282"}}, "5417": {"$insert": {"CARD_short_name": "PDC-283"}}, "3382": {"$update": {"ARO_description": "A novel Tn4551 streptomycin-resistance gene that was phenotypically silent in wild-type Bacteroides; expression could be activated by a trans-acting chromosomal mutation.", "ARO_category": {"$update": {"36364": {"$update": {"category_aro_description": "Nucelotidylylation of streptomycin at the hydroxyl group at position 6."}}}}}, "$insert": {"CARD_short_name": "aadS"}}, "3383": {"$update": {"ARO_description": "A mobilized and plasmid-mediated colistin resistance gene and phosphoethanolamine transferase identified from a Salmonella enterica isolate.", "model_sequences": {"$update": {"sequence": {"$update": {"5569": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Enterobacterales"}}}}}}}}, "model_name": "MCR-9.1"}, "$insert": {"CARD_short_name": "MCR-9.1"}}, "3380": {"$update": {"ARO_description": "Point mutations in the rpoC region of Clostridioides difficile which confer resistance to vancomycin.", "ARO_category": {"$update": {"42780": {"$update": {"category_aro_description": "Point mutations in rpoC, an RNA polymerase subunit, which confer resistance to vancomycin."}}}}}, "$insert": {"CARD_short_name": "Cdif_rpoC_VAN"}}, "3381": {"$update": {"ARO_description": "Small mobilizable plasmid pALWED1.8 containing a novel variant of the streptomycin/spectinomycin resistance gene.", "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA27"}}, "1490": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"818": {"$update": {"dna_sequence": {"$update": {"accession": "AM941848.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-907"}}, "5418": {"$insert": {"CARD_short_name": "PDC-286"}}, "5419": {"$insert": {"CARD_short_name": "PDC-287"}}, "3388": {"$insert": {"CARD_short_name": "MCR-1.12"}}, "3389": {"$update": {"ARO_description": "A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli."}, "$insert": {"CARD_short_name": "MCR-1.13"}}, "1409": {"$update": {"ARO_description": "CMY-6 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1548": {"$update": {"dna_sequence": {"$update": {"accession": "AJ011293.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-6"}}, "1408": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1398": {"$update": {"dna_sequence": {"$update": {"accession": "AY327540.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-390"}}, "4437": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-53"}}, "4963": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-637"}}, "1407": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1777": {"$update": {"dna_sequence": {"$update": {"accession": "JF460796.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-62"}}, "1406": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1290": {"$update": {"dna_sequence": {"$update": {"accession": "KF057027.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-121"}}, "1405": {"$insert": {"CARD_short_name": "armA"}}, "1404": {"$update": {"ARO_description": "IMP-3 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1092": {"$update": {"dna_sequence": {"$update": {"accession": "AB010417.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-3"}}, "4215": {"$insert": {"CARD_short_name": "ADC-145"}}, "1546": {"$update": {"ARO_description": "Erm(43) is a macrolide, lincosamide, and streptogramin B resistance gene found in Mammaliicoccus lentus chromosome isolated from human, dog and chicken.", "model_sequences": {"$update": {"sequence": {"$update": {"3291": {"$update": {"dna_sequence": {"$update": {"accession": "HE650138.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Mammaliicoccus lentus"}}}}}}}}}, "$insert": {"CARD_short_name": "Erm(43)"}}, "449": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1144": {"$update": {"dna_sequence": {"$update": {"accession": "AB551737.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-133"}}, "448": {"$update": {"ARO_description": "dfrG is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus.", "model_sequences": {"$update": {"sequence": {"$update": {"750": {"$update": {"dna_sequence": {"$update": {"accession": "AB205645.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrG"}}, "1339": {"$update": {"ARO_description": "Point mutation in the M.tuberculosis embR results in increased resistance to ethambutol.", "ARO_category": {"$update": {"40047": {"$update": {"category_aro_description": "Mutations that occurs on the embR genes resulting in the resistance to ethambutol."}}}}}, "$insert": {"CARD_short_name": "Mtub_embR_EMB"}}, "1338": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1545": {"$update": {"dna_sequence": {"$update": {"accession": "AY453161.1"}}}}}}}}, "model_name": "Bla1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Bla1"}}, "4213": {"$insert": {"CARD_short_name": "ADC-143"}}, "1547": {"$update": {"ARO_description": "Also known as vanRC, is a vanR variant found in the vanC gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"105": {"$update": {"dna_sequence": {"$update": {"accession": "AF162694.1"}}}}}}}}, "model_name": "vanR gene in vanC cluster", "ARO_name": "vanR gene in vanC cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanC_cl"}}, "443": {"$update": {"ARO_description": "OKP-B-10 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"795": {"$update": {"dna_sequence": {"$update": {"accession": "AM051160.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-10"}}, "442": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}, "model_name": "OpmD"}, "$insert": {"CARD_short_name": "OpmD"}}, "441": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"893": {"$update": {"dna_sequence": {"$update": {"accession": "AY500137.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MexA"}}, "447": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1237": {"$update": {"dna_sequence": {"$update": {"accession": "DQ174307.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-67"}}, "446": {"$update": {"ARO_description": "catB8 is a plasmid or integron-encoded variant of the cat gene found in Klebsiella pneumoniae, Salmonella typhi and Pseudomonas aeruginosa.", "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-22"}}, "444": {"$update": {"ARO_description": "AAC(6')-Ib-Suzhou is an aminoglycoside acetyltransferase in E. cloacae and K. pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"83": {"$update": {"dna_sequence": {"$update": {"accession": "EU085533.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC_6_IB_Su"}}, "1545": {"$update": {"ARO_description": "Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance."}, "$insert": {"CARD_short_name": "Ecol_gyrA_FLO"}}, "4947": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-621"}}, "4623": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-40"}}, "4436": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-52"}}, "1542": {"$insert": {"CARD_short_name": "amrA"}}, "832": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2022": {"$update": {"dna_sequence": {"$update": {"accession": "JX121128.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-161"}}, "1543": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1035": {"$update": {"dna_sequence": {"$update": {"accession": "DQ256079.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-22"}}, "39": {"$update": {"ARO_description": "AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"8360": {"dna_sequence": {"partial": "0", "sequence": "ATGGGCATCATTCGCACATGTAGGCTCGGCCCTGACCAAGTCAAATCCATGCGGGCTGCTCTTGATCTTTTCGGTCGTGAGTTCGGAGACGTAGCCACCTACTCCCAACATCAGCCGGACTCCGATTACCTCGGGAACTTGCTCCGTAGTAAGACATTCATCGCGCTTGCTGCCTTCGACCAAGAAGCGGTTGTTGGCGCTCTCGCGGCTTACGTTCTGCCCAGGTTTGAGCAGCCGCGTAGTGAGATCTATATCTATGATCTCGCAGTCTCCGGCGAGCACCGGAGGCAGGGCATTGCCACCGCGCTCATCAATCTCCTCAAGCATGAGGCCAACGCGCTTGGTGCTTATGTGATCTACGTGCAAGCAGATTACGGTGACGATCCCGCAGTGGCTCTCTATACAAAGTTGGGCATACGGGAAGAAGTGATGCACTTTGATATCGACCCAAGTACCGCCACCTAA", "fmax": "5520", "accession": "U12338.3", "fmin": "5055", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AAG15269.1", "sequence": "MGIIRTCRLGPDQVKSMRAALDLFGREFGDVATYSQHQPDSDYLGNLLRSKTFIALAAFDQEAVVGALAAYVLPRFEQPRSEIYIYDLAVSGEHRRQGIATALINLLKHEANALGAYVIYVQADYGDDPAVALYTKLGIREEVMHFDIDPSTAT"}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-Ia"}}, "38": {"$update": {"ARO_description": "APH(3')-Va is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces fradiae.", "model_sequences": {"$update": {"sequence": {"$update": {"371": {"$update": {"dna_sequence": {"$update": {"accession": "K00432.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-Va"}}, "1540": {"$insert": {"CARD_short_name": "rmtC"}}, "1057": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1980": {"$update": {"dna_sequence": {"$update": {"accession": "GQ351346.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-114"}}, "5578": {"$insert": {"CARD_short_name": "PDC-451"}}, "33": {"$insert": {"CARD_short_name": "msrE"}}, "32": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"910": {"$update": {"dna_sequence": {"$update": {"accession": "KM087853.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-15"}}, "31": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1666": {"$update": {"dna_sequence": {"$update": {"accession": "KM211508.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-155"}}, "30": {"$update": {"ARO_description": "OXA-226 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1927": {"$update": {"dna_sequence": {"$update": {"accession": "FJ617207.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-226"}}, "37": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"561": {"$update": {"dna_sequence": {"$update": {"accession": "JQ394987.1"}}}}}}}}, "ARO_category": {"$update": {"40514": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$delete": ["40518"], "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Ecol_mdfA"}}, "36": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2059": {"$update": {"dna_sequence": {"$update": {"accession": "AL450380.1"}}}}}}}}, "model_name": "Mycobacterium leprae gyrA conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Mlep_gyrA_FLO"}}, "35": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"341": {"$update": {"dna_sequence": {"$update": {"accession": "EU487198.1"}}}}}}}}}, "$insert": {"CARD_short_name": "FosA2"}}, "34": {"$update": {"ARO_description": "OXY-6-3 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1060": {"$update": {"dna_sequence": {"$update": {"accession": "AJ871876.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-6-3"}}, "1537": {"$update": {"ARO_description": "GES-2 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1172": {"$update": {"dna_sequence": {"$update": {"accession": "AF326355.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-2"}}, "1536": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-421"}}, "643": {"$update": {"ARO_description": "OXY-2-5 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1467": {"$update": {"dna_sequence": {"$update": {"accession": "AJ746227.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-5"}}, "1242": {"$update": {"ARO_description": "aadA6/aadA10 is an integron-encoded aminoglycoside nucleotidyltransferase gene cassette in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"409": {"$update": {"dna_sequence": {"$update": {"accession": "AM087405.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA6/aadA10"}}, "645": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mecR1"}}, "644": {"$update": {"ARO_description": "OXY-2-1 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1059": {"$update": {"dna_sequence": {"$update": {"accession": "AJ871866.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-1"}}, "647": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1727": {"$update": {"dna_sequence": {"$update": {"accession": "AY039040.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-89"}}, "1246": {"$update": {"ARO_description": "AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis."}, "$insert": {"CARD_short_name": "AAC(2')-Ic"}}, "649": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1999": {"$update": {"dna_sequence": {"$update": {"accession": "EU029998.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-115"}}, "1248": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "H-NS"}}, "5346": {"$insert": {"CARD_short_name": "PDC-208"}}, "1539": {"$update": {"ARO_description": "aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli.", "model_sequences": {"$update": {"sequence": {"8168": {"dna_sequence": {"partial": "0", "sequence": "ATGAGGGTAGCGGTGACCATCGAAATTTCGAACCAACTATCAGAGGTGCTAAGCGTCATTGAGCGCCATCTGGAATCAACGTTGCTGGCCGTGCATTTGTACGGCTCCGCAGTGGATGGCGGCCTGAAGCCATACAGCGATATTGATTTGTTGGTTACTGTGGCCGTAAAGCTTGATGAAACGACGCGGCGAGCATTGCTCAATGACCTTATGGAGGCTTCGGCTTTCCCTGGCGAGAGCGAGACGCTCCGCGCTATAGAAGTCACCCTTGTCGTGCATGACGACATCATCCCGTGGCGTTATCCGGCTAAGCGCGAGCTGCAATTTGGAGAATGGCAGCGCAATGACATTCTTGCGGGTATCTTCGAGCCAGCCATGATCGACATTGATCTAGCTATCCTGCTTACAAAAGCAAGAGAACATAGCGTTGCCTTGGTAGGTCCGGCAGCGGAGGAATTCTTTGACCCGGTTCCTGAACAGGATCTATTCGAGGCGCTGAGGGAAACCTTGAAGCTATGGAACTCGCAGCCCGACTGGGCCGGCGATGAGCGAAATGTAGTGCTTACGTTGTCCCGCATTTGGTACAGCGCAATAACCGGCAAAATCGCGCCGAAGGATGTCGCTGCCGACTGGGCAATAAAACGCCTACCTGCCCAGTATCAGCCCGTCTTACTTGAAGCTAAGCAAGCTTATCTGGGACAAAAAGAAGATCACTTGGCCTCACGCGCAGATCACTTGGAAGAATTTATTCACTACGTGAAAGGCGAGATCACCAAGGTAGTCGGCAAATAA", "fmax": "2087", "accession": "AF047479.2", "fmin": "1295", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Plasmid NR79", "NCBI_taxonomy_id": "2468", "NCBI_taxonomy_cvterm_id": "36872"}, "protein_sequence": {"accession": "AAC14728.1", "sequence": "MRVAVTIEISNQLSEVLSVIERHLESTLLAVHLYGSAVDGGLKPYSDIDLLVTVAVKLDETTRRALLNDLMEASAFPGESETLRAIEVTLVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPAMIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLFEALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQPVLLEAKQAYLGQKEDHLASRADHLEEFIHYVKGEITKVVGK"}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA3"}}, "1538": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1850": {"$update": {"dna_sequence": {"$update": {"accession": "EU274581.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-104"}}, "1493": {"$update": {"ARO_description": "PER-6 is a beta-lactamase found in Aeromonas allosaccharophila.", "model_sequences": {"$update": {"sequence": {"$update": {"1229": {"$update": {"dna_sequence": {"$update": {"accession": "GQ396303.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-6"}}, "339": {"$update": {"model_sequences": {"$update": {"sequence": {"8182": {"dna_sequence": {"partial": "0", "sequence": "ATGAGTAACGCAGTACCCGCCGAGATTTCGGTACAGCTATCACTGGCTCTCAACGCCATCGAGCGTCATCTGGAATCAACGTTGCTGGCCGTGCATTTGTACGGCTCTGCACTGGACGGTGGCCTGAAGCCATACAGTGATATTGATTTGCTGGTTACTGTGGCTGCACAGCTCGATGAGACTGTCCGACAAGCCCTGGTCGTAGATCTCTTGGAAATTTCTGCCTCCCCTGGCCAAAGTGAGGCTCTCCGCGCCTTGGAAGTTACCATCGTCGTGCATGGTGATGTTGTCCCTTGGCGTTATCCGGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGTAAAGACATTCTTGCGGGCATCTTCGAGCCCGCCACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGTAAGGCAGCATAGCCTTGCATTGGCAGGTTCGGCCGCAGAGGATTTCTTTAACCCAGTTCCGGAAGGCGATCTATTCAAGGCATTGAGCGACACTCTGAAACTATGGAATTCGCAGCCGGATTGGGAAGGCGATGAGCGGAATGTAGTGCTTACCTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCACCGAAGGATATCGTTGCCAACTGGGCAATTGAGCGTCTGCCAGATCAACATAAGCCCGTACTGCTTGAAGCCCGGCAGGCTTATCTTGGACGAGGAGAAGATTGCTTGGCCTCACGCGCGGATCAGTTGGCGGCGTTCGTTCACTTCGTGAAACATGAAGCCACTAAATTGCTTGGTGCCATGCCAGTGATGTCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "fmax": "4946", "accession": "AF453998.2", "fmin": "3554", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Serratia marcescens", "NCBI_taxonomy_id": "615", "NCBI_taxonomy_cvterm_id": "36783"}, "protein_sequence": {"accession": "AAL51021.2", "sequence": "MSNAVPAEISVQLSLALNAIERHLESTLLAVHLYGSALDGGLKPYSDIDLLVTVAAQLDETVRQALVVDLLEISASPGQSEALRALEVTIVVHGDVVPWRYPARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKVRQHSLALAGSAAEDFFNPVPEGDLFKALSDTLKLWNSQPDWEGDERNVVLTLSRIWYSAATGKIAPKDIVANWAIERLPDQHKPVLLEARQAYLGRGEDCLASRADQLAAFVHFVKHEATKLLGAMPVMSKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA"}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "ANT3Ii_AAC6_IID"}}, "338": {"$update": {"ARO_description": "OXY-1-2 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"2016": {"$update": {"dna_sequence": {"$update": {"accession": "AJ871865.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-1-2"}}, "4391": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-3"}}, "335": {"$update": {"ARO_description": "Point mutation in Staphylococcus aureus parE resulting in fluoroquinolones resistance."}, "$insert": {"CARD_short_name": "Saur_parE_FLO"}}, "334": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"244": {"$update": {"dna_sequence": {"$update": {"accession": "AB015853.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mexX"}}, "337": {"$insert": {"CARD_short_name": "adeC"}}, "3266": {"$update": {"ARO_description": "CAM-1 is a CAM (Central Alberta Metallo) beta-lactamase and carbapenemase identified from 4 clinical isolates of Pseudomonas aeruginosa from a Canadian hospital.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40636": {"$update": {"category_aro_description": "A fifth generation cephalosporin antibiotic."}}}}}, "$insert": {"CARD_short_name": "CAM-1"}}, "5003": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-26"}}, "333": {"$update": {"ARO_description": "Present in Lahey's list of beta-lactamases, not yet released.", "model_sequences": {"$update": {"sequence": {"$update": {"1420": {"$update": {"dna_sequence": {"$update": {"accession": "CP007005.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-23"}}, "332": {"$update": {"ARO_description": "Class A beta-lactamase found in Actinomadura R39.", "model_sequences": {"$update": {"sequence": {"$update": {"3308": {"$update": {"dna_sequence": {"$update": {"accession": "X53650.1"}}}}}}}}, "model_name": "R39", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "R39"}}, "4101": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-36 [Klebsiella pneumoniae] Accession: WP_114699267.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-38"}}, "4102": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-37 [Klebsiella pneumoniae] Accession: WP_116786832.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-37"}}, "4105": {"$update": {"ARO_description": "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-40 [Enterobacter hormaechei] Accession: WP_115470049.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-40"}}, "4104": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-39 [Klebsiella pneumoniae] Accession: WP_128268237.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-39"}}, "4107": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-42 [Klebsiella pneumoniae] Accession: WP_136512070.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-42"}}, "3268": {"$update": {"ARO_description": "Point mutations in gyrB of Clostridioides difficile conferring resistance to fluoroquinolone antibiotics.", "model_name": "Clostridioides difficile gyrB conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Cdif_gyrB_FLO"}}, "4109": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-45 [Enterobacter cloacae] Accession: WP_148044420.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-45"}}, "4108": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-43 [Klebsiella pneumoniae] Accession: WP_136512071.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-823"}}, "5127": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-824"}}, "5002": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-690"}}, "1901": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1256": {"$update": {"dna_sequence": {"$update": {"accession": "DQ211987.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-51"}}, "3898": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6259": {"$update": {"dna_sequence": {"$update": {"accession": "NG_056410.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-156"}}, "3899": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6260": {"$update": {"dna_sequence": {"$update": {"accession": "NG_057614.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-160"}}, "3892": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6253": {"$update": {"dna_sequence": {"$update": {"accession": "NG_048777.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-107"}}, "3893": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6254": {"$update": {"dna_sequence": {"$update": {"accession": "NG_062242.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-158"}}, "3890": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6251": {"$update": {"dna_sequence": {"$update": {"accession": "KP860987.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-134"}}, "3891": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6252": {"$update": {"dna_sequence": {"$update": {"accession": "NG_052047.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-143"}}, "3896": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6257": {"$update": {"dna_sequence": {"$update": {"accession": "NG_052898.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-147"}}, "3897": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6258": {"$update": {"dna_sequence": {"$update": {"accession": "NG_052648.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-146"}}, "3894": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6255": {"$update": {"dna_sequence": {"$update": {"accession": "NG_070783.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-173"}}, "1468": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1311": {"$update": {"dna_sequence": {"$update": {"accession": "HQ637576.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-304"}}, "5001": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-689"}}, "5133": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-831"}}, "3465": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-303"}}, "1464": {"$update": {"ARO_description": "aadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"516": {"$update": {"dna_sequence": {"$update": {"accession": "AB114632.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA7"}}, "3464": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-302"}}, "1085": {"$update": {"ARO_description": "OKP-B-5 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8269": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAAGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACACCGCCGGCAATCTGCTGTTGAAGATCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGCTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTTGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGTGATACCCCGGCGACCATGGTCGAGCGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "885", "accession": "AM850918.2", "fmin": "24", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12356.2", "sequence": "MRYVRLCLISLIAALPLAVFASPQPLEQIKISESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNTAGNLLLKIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTPATMVERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-5"}}, "8": {"$update": {"ARO_description": "NDM-6 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1103": {"$update": {"dna_sequence": {"$update": {"accession": "JN967644.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-6"}}, "3463": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-301"}}, "1496": {"$update": {"ARO_description": "OXA-224 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"8176": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAACACAATACATATCAACTTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGTATCCACAAACACTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGAGAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTAAACACACTAAATTTATAA", "fmax": "3111", "accession": "JN596991.2", "fmin": "2280", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AEQ73521.1", "sequence": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDVSTNTEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-224"}}, "2119": {"$update": {"ARO_description": "LRA-10 is a beta-lactamase isolated from soil samples in Alaska.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-10"}}, "2154": {"$update": {"ARO_description": "Point mutations in the 3' major domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to spectinomycin."}, "$insert": {"CARD_short_name": "Bbur_16S_SPT"}}, "3462": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-300"}}, "1466": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1063": {"$update": {"dna_sequence": {"$update": {"accession": "AF164577.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-13"}}, "4079": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6452": {"$update": {"dna_sequence": {"$update": {"accession": "NG_070720.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DfrA37"}}, "841": {"$update": {"ARO_description": "CTX-M-14 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"8283": {"dna_sequence": {"partial": "0", "sequence": "ATGGTGACAAAGAGAGTGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTGCTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCGCAGATAATACGCAGGTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCAAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATGACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGTGGGTGATAAGACCGGCAGCGGCGACTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTGGTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTGGCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA", "fmax": "2616", "accession": "AF252622.2", "fmin": "1740", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAF72530.1", "sequence": "MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-14"}}, "5000": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-688"}}, "4075": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6448": {"$update": {"dna_sequence": {"$update": {"accession": "NG_049775.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-499"}}, "4074": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6447": {"$update": {"dna_sequence": {"$update": {"accession": "NG_057615.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-653"}}, "4077": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6450": {"$update": {"dna_sequence": {"$update": {"accession": "NG_070721.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DfrA43_TMP"}}, "840": {"$update": {"ARO_description": "CMY-20 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8195": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCCGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGTTTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAACAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTCCAATAA", "fmax": "1143", "accession": "AY960293.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAX58682.2", "sequence": "MKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ"}}}}}}, "$insert": {"CARD_short_name": "CMY-20"}}, "4071": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6444": {"$update": {"dna_sequence": {"$update": {"accession": "NG_065432.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-646"}}, "4070": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6443": {"$update": {"dna_sequence": {"$update": {"accession": "NG_065434.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-648"}}, "4073": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6446": {"$update": {"dna_sequence": {"$update": {"accession": "NG_068017.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-897"}}, "4072": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6445": {"$update": {"dna_sequence": {"$update": {"accession": "NG_057485.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-649"}}, "3966": {"$update": {"ARO_description": "ADC ortholog described by Nodari et al. 2020."}, "$insert": {"CARD_short_name": "ADC-181"}}, "3967": {"$update": {"ARO_description": "ADC ortholog described by Nodari et al. 2020."}, "$insert": {"CARD_short_name": "ADC-182"}}, "3964": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-209"}}, "3965": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-215"}}, "3962": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-224"}}, "3963": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-225"}}, "1910": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2042": {"$update": {"dna_sequence": {"$update": {"accession": "KC351754.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-136"}}, "3961": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 08-JUN-2016.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-193"}}, "1497": {"$update": {"ARO_description": "dfrA10 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8272": {"dna_sequence": {"partial": "0", "sequence": "ATGAATATATCACTTATCTTTGCCAATGAATTAATTACCAGAGCATTCGGTAATCAAGGCAAATTACCTTGGCAATTCATTAAAGAAGATATGCAGTTCTTCCAGAAGACTACAGAAAATTCTGTAGTCGTTATGGGATTAAATACATGGAGATCTCTACCTAAGATGAAGAAGCTTGGTAGAGACTTCATTGTCATATCTTCAACTATCACAGAGCACGAAGTGCTCAACAATAATATCCAAATATTCAAATCATTTGAGAGCTTCTTAGAAGCATTCAGAGACACAACCAAACCAATCAATGTCATTGGTGGTGTTGGTTTATTATCTGAAGCGATAGAACATGCTAGCACTGTTTACATGAGTTCTATTCATATGGTTAAACCTGTTCATGCTGATGTGTATGTACCGGTAGAACTAATGAATAAACTCTATAGTGATTTCAAATATCCAGAAAATATTCTATGGGTAGGTGATCCAATAGATTCTGTGTATAGCTTGTCTATTGATAAGTTTGTTAGACCAGCTTCGCTGGTTGGGGTGCCAAATGATATTAATACGTGA", "fmax": "112122", "accession": "KF976462.2", "fmin": "111558", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AHG97174.1", "sequence": "MNISLIFANELITRAFGNQGKLPWQFIKEDMQFFQKTTENSVVVMGLNTWRSLPKMKKLGRDFIVISSTITEHEVLNNNIQIFKSFESFLEAFRDTTKPINVIGGVGLLSEAIEHASTVYMSSIHMVKPVHADVYVPVELMNKLYSDFKYPENILWVGDPIDSVYSLSIDKFVRPASLVGVPNDINT"}}}}}}, "$insert": {"CARD_short_name": "dfrA10"}}, "1462": {"$update": {"ARO_description": "LRA-19 is a beta-lactamase isolated from soil samples in Alaska.", "model_sequences": {"$update": {"sequence": {"$update": {"1748": {"$update": {"dna_sequence": {"$update": {"accession": "EU408359.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-19"}}, "1962": {"$update": {"ARO_description": "OXA-47 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1614": {"$update": {"dna_sequence": {"$update": {"accession": "AY237830.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-47"}}, "5081": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-772"}}, "3968": {"$update": {"ARO_description": "ADC ortholog described by Nodari et al. 2020."}, "$insert": {"CARD_short_name": "ADC-183"}}, "3969": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-228"}}, "2854": {"$update": {"ARO_description": "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-75"}}, "1101": {"$update": {"ARO_description": "CTX-M-21 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1255": {"$update": {"dna_sequence": {"$update": {"accession": "AJ416346.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-21"}}, "3638": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5909": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Klebsiella variicola subsp. tropica"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-39"}}, "3639": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5910": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Klebsiella variicola subsp. tropica"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-40"}}, "3636": {"$update": {"ARO_description": "A class-A beta-lactamase from Klebsiella variicola.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-34"}}, "3637": {"$update": {"ARO_description": "A class-A beta-lactamase from Klebsiella.", "model_sequences": {"$update": {"sequence": {"$update": {"5908": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Klebsiella variicola subsp. tropica"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-38"}}, "3634": {"$update": {"ARO_description": "A class-A beta-lactamase from Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"5905": {"$update": {"protein_sequence": {"$update": {"accession": "SLY33602.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-30"}}, "3635": {"$update": {"ARO_description": "A class-A beta-lactamase from Klebsiella variicola.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-32"}}, "3633": {"$update": {"ARO_description": "An OXA-12-family class D beta-lactamase identified from Aeromonas hydrophila.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-724"}}, "3631": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5848": {"$update": {"dna_sequence": {"$update": {"accession": "LR134358.1"}}}}}}}}, "model_name": "Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40661": {"$update": {"category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}}}}}, "$insert": {"CARD_short_name": "Ngon_pilQ_BLA"}}, "1400": {"$update": {"ARO_description": "CTX-M-74 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1668": {"$update": {"dna_sequence": {"$update": {"accession": "GQ149243.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-74"}}, "4611": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-30"}}, "2345": {"$insert": {"CARD_short_name": "ADC-15"}}, "2344": {"$insert": {"CARD_short_name": "ADC-14"}}, "2347": {"$insert": {"CARD_short_name": "ADC-17"}}, "4612": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-29"}}, "2341": {"$insert": {"CARD_short_name": "ADC-8"}}, "2340": {"$insert": {"CARD_short_name": "ADC-7"}}, "2343": {"$insert": {"CARD_short_name": "ADC-13"}}, "2342": {"$insert": {"CARD_short_name": "ADC-12"}}, "4615": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-32"}}, "2349": {"$insert": {"CARD_short_name": "ADC-19"}}, "2348": {"$insert": {"CARD_short_name": "ADC-18"}}, "4614": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-34"}}, "1350": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2039": {"$update": {"dna_sequence": {"$update": {"accession": "AJ318093.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-33"}}, "5005": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-693"}}, "1639": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1395": {"$update": {"dna_sequence": {"$update": {"accession": "AM087453.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-84"}}, "3336": {"$update": {"ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "qnrE2"}}, "2346": {"$insert": {"CARD_short_name": "ADC-16"}}, "3669": {"$update": {"ARO_description": "A class B New Delhi metallo-beta-lactamase and NDM-1 variant.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-28"}}, "4468": {"$insert": {"CARD_short_name": "CMH-6"}}, "4469": {"$insert": {"CARD_short_name": "CMY-106"}}, "1887": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1496": {"$update": {"dna_sequence": {"$update": {"accession": "AF188199.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-70"}}, "1886": {"$update": {"ARO_description": "LEN-24 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8217": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCAACCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "891", "accession": "AM850914.2", "fmin": "30", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12352.2", "sequence": "MRYVRLCVISLLANLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-534"}}, "2019": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1128": {"$update": {"dna_sequence": {"$update": {"accession": "JN861781.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-213"}}, "2018": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1664": {"$update": {"dna_sequence": {"$update": {"accession": "JQ733573.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-76"}}, "1930": {"$update": {"ARO_description": "CTX-M-29 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1862": {"$update": {"dna_sequence": {"$update": {"accession": "AY267213.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-29"}}, "4862": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7237": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-527"}}, "2014": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2115": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}, "model_name": "PmrF"}, "$insert": {"CARD_short_name": "PmrF"}}, "2017": {"$update": {"ARO_description": "CTX-M-37 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"8243": {"dna_sequence": {"partial": "0", "sequence": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGCATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCAGCAGTCGGGAGGAAGGCTGGGTGTGGCATTGATTAACACAGCGGATAATTCGCAAATACTTTATCGTGCAGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTGGTTAACTATAATCCGATTGCGGAAAAGCACGTCGATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGCACCGAGCCGACGTTAAACACAGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACGCTGCGTAATCTGACGCTGGGTAAAGCATTGGGTGACAGCCAACGGGCGCAGCTGGTGACGTGGATGAAAGGCAATACTACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGACTATGGTACCACCAACGATATCGCGGTGATTTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCCCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAG", "fmax": "2516", "accession": "AY649755.2", "fmin": "1640", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550", "NCBI_taxonomy_cvterm_id": "36884"}, "protein_sequence": {"accession": "AAT70415.1", "sequence": "MVKKSLRQFTLMATATVTLLLGSVPLHAQTADVQQKLAELEQQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-37"}}, "2016": {"$update": {"ARO_description": "OXA-370 is a beta-lactamase found in Enterobacter hormaechei.", "model_sequences": {"$update": {"sequence": {"$update": {"1214": {"$update": {"dna_sequence": {"$update": {"accession": "KF900153.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-370"}}, "2011": {"$update": {"ARO_description": "QnrB60 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"690": {"$update": {"dna_sequence": {"$update": {"accession": "AB734055.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB60"}}, "2010": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1550": {"$update": {"dna_sequence": {"$update": {"accession": "JX017364.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-129"}}, "2013": {"$update": {"model_sequences": {"$update": {"sequence": {"8253": {"dna_sequence": {"partial": "1", "sequence": "GTGGATCTGGGCGCAGGACACGGCGCGCTGACGGCACATCTGGTTGCCGCTGGCGCCAGGGTGCTAGCCGTCGAGCTGCATCCGGGGCGGGCTCGACACCTTCGTTCACGGTTTGCCGAGGAAGATGTCCGGGTAGCGGAAGCGGACCTACTCGCCTTCCGGTGGCCGCGACGGCCATTTCGGGTGGTGGCGAGCCCGCCCTACCAAGTCACCAGCGCACTGATCCGGAGTCTCTTGACGCCGGAATCCCGGCTGCTGGCTGCCGACCTGGTGCTGCAGCGCGGGGCTGTGCACAAACATGCGAAGCGAGCACCTGTTCGCCATTGGACGCTACGGGCCGGAATCACATTGCCGCGAAGCGCTTTCCATCATCCACCGCAGGTGGATTCGTCGGTGCTGGTGATCAGGCGGCGCTGACCCTGTGACAGACTGCGGGCATGTTGCGTATCGGCCTAACCGGTGGAATCGGTGCGGGGAAGTCCACCGTCTCGCGGACCCTCGCCGGGTGCGGGGCTTTCATCGTGGACAGCGATGTGATCGCACGCGAGGTGGTGGAACCCGGAACGCCTGGGCTGGCGGCGCTCGTGGAGGCCTTTG", "fmax": "3649", "accession": "EU177504.3", "fmin": "3052", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacteroides abscessus", "NCBI_taxonomy_id": "36809", "NCBI_taxonomy_cvterm_id": "36888"}, "protein_sequence": {"accession": "ABW06859.1", "sequence": "MDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSRFAEEDVRVAEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHPPQVDSSVLVIRRR"}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Erm(41)"}}, "4865": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-530"}}, "5160": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-863"}}, "5349": {"$insert": {"CARD_short_name": "PDC-211"}}, "3386": {"$insert": {"CARD_short_name": "MCR-1.8"}}, "5582": {"$insert": {"CARD_short_name": "PDC-455"}}, "5451": {"$insert": {"CARD_short_name": "PDC-320"}}, "5277": {"$insert": {"CARD_short_name": "PDC-140"}}, "1937": {"$update": {"ARO_description": "OXA-118 is a beta-lactamase found in Burkholderia cepacia.", "model_sequences": {"$update": {"sequence": {"$update": {"965": {"$update": {"dna_sequence": {"$update": {"accession": "AF371964.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-118"}}, "3277": {"$insert": {"CARD_short_name": "Abau_AbaF"}}, "1793": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"827": {"$update": {"dna_sequence": {"$update": {"accession": "KM087854.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-14"}}, "3562": {"$insert": {"CARD_short_name": "BIL-1"}}, "3563": {"$insert": {"CARD_short_name": "BKC-1"}}, "3560": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BES-1"}}, "3561": {"$insert": {"CARD_short_name": "BIC-1"}}, "3566": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CBP-1"}}, "3564": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BPU-1"}}, "3335": {"$update": {"ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "qnrE1"}}, "4594": {"$insert": {"CARD_short_name": "EC-5"}}, "3568": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CGA-1"}}, "2112": {"$insert": {"CARD_short_name": "patB"}}, "511": {"$update": {"ARO_description": "dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"69": {"$update": {"dna_sequence": {"$update": {"accession": "J03306.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA3"}}, "5270": {"$insert": {"CARD_short_name": "PDC-133"}}, "4484": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6859": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "CRP-1"}}, "4485": {"$insert": {"CARD_short_name": "CSA-1"}}, "1936": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1820": {"$update": {"dna_sequence": {"$update": {"accession": "DQ102702.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-43"}}, "4487": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6862": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "CSP-1"}}, "4480": {"$insert": {"CARD_short_name": "CRD3-1"}}, "4481": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6856": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "CRH-1"}}, "4482": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6857": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "CRH-2"}}, "5598": {"$insert": {"CARD_short_name": "PDC-472"}}, "5413": {"$insert": {"CARD_short_name": "PDC-279"}}, "4488": {"$insert": {"CARD_short_name": "CTX-M-127"}}, "4489": {"$insert": {"CARD_short_name": "CTX-M-138"}}, "4243": {"$insert": {"CARD_short_name": "ADC-175"}}, "2902": {"$insert": {"CARD_short_name": "ICR-Mc"}}, "2901": {"$insert": {"CARD_short_name": "CFE-2"}}, "2900": {"$update": {"ARO_description": "EBR-2 is a novel EBR-like class B beta-lactamase isolated from an extensively drug-resistant strain of Empedobacter falsenii.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-27"}}, "4892": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-563"}}, "705": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1098": {"$update": {"dna_sequence": {"$update": {"accession": "KM087840.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-116"}}, "706": {"$update": {"ARO_description": "APH(7'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. hygroscopicus.", "model_sequences": {"$update": {"sequence": {"$update": {"600": {"$update": {"dna_sequence": {"$update": {"accession": "X03615.1"}}}}}}}}, "ARO_category": {"$update": {"36293": {"$update": {"category_aro_description": "Phosphorylation of hygromycin on the hydroxyl group at position 7''."}}}}}, "$insert": {"CARD_short_name": "APH(7'')-Ia"}}, "707": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1033": {"$update": {"dna_sequence": {"$update": {"accession": "AM998375.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-129"}}, "3260": {"$update": {"ARO_description": "A dihydrofolate reductase and trimethoprim resistance gene from Klebsiella pneumoniae."}, "$insert": {"CARD_short_name": "dfrA30"}}, "703": {"$update": {"ARO_description": "cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae.", "model_sequences": {"$update": {"sequence": {"$update": {"82": {"$update": {"dna_sequence": {"$update": {"accession": "U09991.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cmlv"}}, "3387": {"$insert": {"CARD_short_name": "MCR-1.11"}}, "88": {"$update": {"ARO_description": "CMY-55 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1116": {"$update": {"dna_sequence": {"$update": {"accession": "HM544040.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-55"}}, "89": {"$update": {"ARO_description": "Also known as vanYA, is a vanY variant found in the vanA gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3278": {"$update": {"dna_sequence": {"$update": {"accession": "M97297.1"}}}}}}}}, "model_name": "vanY gene in vanA cluster", "ARO_name": "vanY gene in vanA cluster"}, "$insert": {"CARD_short_name": "vanY_in_vanA_cl"}}, "4940": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-614"}}, "5338": {"$insert": {"CARD_short_name": "PDC-199"}}, "82": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1061": {"$update": {"dna_sequence": {"$update": {"accession": "EU748544.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PER-4"}}, "80": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1095": {"$update": {"dna_sequence": {"$update": {"accession": "KM087832.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-29"}}, "81": {"$update": {"ARO_description": "FOX-3 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1109": {"$update": {"dna_sequence": {"$update": {"accession": "Y11068.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-3"}}, "86": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"923": {"$update": {"dna_sequence": {"$update": {"accession": "AY040093.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-102"}}, "87": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-116"}}, "84": {"$update": {"ARO_description": "GIM-1 is an integron-encoded B1 beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"952": {"$update": {"dna_sequence": {"$update": {"accession": "AJ620678.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GIM-1"}}, "85": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2048": {"$update": {"dna_sequence": {"$update": {"accession": "AB753456.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-42"}}, "5319": {"$insert": {"CARD_short_name": "PDC-18"}}, "5318": {"$insert": {"CARD_short_name": "PDC-179"}}, "762": {"$update": {"ARO_description": "CTX-M-55 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1552": {"$update": {"dna_sequence": {"$update": {"accession": "DQ885477.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-55"}}, "5313": {"$insert": {"CARD_short_name": "PDC-174"}}, "5312": {"$insert": {"CARD_short_name": "PDC-172"}}, "5311": {"$insert": {"CARD_short_name": "PDC-171"}}, "5310": {"$insert": {"CARD_short_name": "PDC-170"}}, "5317": {"$insert": {"CARD_short_name": "PDC-178"}}, "5316": {"$insert": {"CARD_short_name": "PDC-177"}}, "5315": {"$insert": {"CARD_short_name": "PDC-176"}}, "5314": {"$insert": {"CARD_short_name": "PDC-175"}}, "1658": {"$update": {"ARO_description": "OKP-B-4 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1599": {"$update": {"dna_sequence": {"$update": {"accession": "AM051153.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-4"}}, "1659": {"$update": {"model_sequences": {"$update": {"sequence": {"8267": {"dna_sequence": {"partial": "0", "sequence": "ATGACAGTTCGACTCGTTTCGCGCGCCCTGGGCGCAGTCCTCTTTGCGTCCGCCCTGACCCTGCCCGCCCGGGCGGACGTCCTGTGCACCCTGGTGGCCGACGCCGCCGACGGCCGCATCCTGTTCCAGCAGGGCACGCGGCAGGACTGCACGCAGCGCTACACCCCCGCCTCGACCTTCAAGCTGCCCATCGCCCTGATGGGCGCGGATGCCGGCATCCTGCAGGGCCCGCACCAGCCCGTCTGGAACTACCAGCCCGCTTATCCCGACTGGGGCGGCGAGGCCTGGCGCCAGCCCACCGATCCGGCTCGCTGGATCAAGTATTCGGTGGTCTGGTACTCGCAGTTGACCGCCAGGGCGCTGGGGCAGGAGCGCTTCCAGCGCTACACCTCCGCGTTCGGTTATGGCAACGCGGACGTCTCGGGTGAACCCGGCAAGCACAACGGCACCGATGGCGCGTGGATCATCTCCTCGCTGCGCATTTCGCCGTTTGAGCAGGTGGACTTCCTGCGCAAGTTCGTCAACCGGCAACTGCCCGTCAAGGCGGCTGCCTATGACCTGGCCGAGAACCTGTTCGAGGTCGGCGAAGCCGACGGCTGGCGTCTGTACGGCAAGACCGGAACCGGCTCGCCCGGCAGCCACGGCGTCTACACGCCGGCCAACGCCTATGGCTGGTTCGTCGGCTGGGCGCGCAAGGACGACCGCCAACTGGTGTTTGCCCGCCTGCTGCAGGACGAGGGGGCGACCCAGCCCAATGCCGGCCTGCGCGCCCGCGACGGCCTGATGCGCGACTGGGCCGCCATGGTCGCGGCGCCCCGCAAATGA", "fmax": "825", "accession": "HE614014.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Achromobacter ruhlandii", "NCBI_taxonomy_id": "72557", "NCBI_taxonomy_cvterm_id": "39091"}, "protein_sequence": {"accession": "CCE73593.2", "sequence": "MTVRLVSRALGAVLFASALTLPARADVLCTLVADAADGRILFQQGTRQDCTQRYTPASTFKLPIALMGADAGILQGPHQPVWNYQPAYPDWGGEAWRQPTDPARWIKYSVVWYSQLTARALGQERFQRYTSAFGYGNADVSGEPGKHNGTDGAWIISSLRISPFEQVDFLRKFVNRQLPVKAAAYDLAENLFEVGEADGWRLYGKTGTGSPGSHGVYTPANAYGWFVGWARKDDRQLVFARLLQDEGATQPNAGLRARDGLMRDWAAMVAAPRK"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-258"}}, "1652": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1173": {"$update": {"dna_sequence": {"$update": {"accession": "AB196988.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-20"}}, "410": {"$update": {"ARO_description": "AAC(3)-IIIb is an aminoglycoside acetyltransferase in P. aeruginosa."}, "$insert": {"CARD_short_name": "AAC(3)-IIIb"}}, "1650": {"$update": {"ARO_description": "CMY-15 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"8201": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAACTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "fmax": "1146", "accession": "AJ555823.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Proteus mirabilis", "NCBI_taxonomy_id": "584", "NCBI_taxonomy_cvterm_id": "36771"}, "protein_sequence": {"accession": "CAD88477.1", "sequence": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ"}}}}}}, "$insert": {"CARD_short_name": "CMY-15"}}, "1651": {"$update": {"ARO_description": "AAC(6')-If is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae.", "model_sequences": {"$update": {"sequence": {"$update": {"358": {"$update": {"dna_sequence": {"$update": {"accession": "X55353.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-If"}}, "1656": {"$update": {"ARO_description": "CTX-M-79 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"769": {"$update": {"dna_sequence": {"$update": {"accession": "EF426798.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-79"}}, "1657": {"$update": {"ARO_description": "AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"460": {"$update": {"dna_sequence": {"$update": {"accession": "AY123251.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-IIa"}}, "1654": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2028": {"$update": {"dna_sequence": {"$update": {"accession": "EF373972.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-95"}}, "1655": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5900": {"$update": {"dna_sequence": {"$update": {"accession": "AY130282.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-117"}}, "586": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1654": {"$update": {"dna_sequence": {"$update": {"accession": "GQ414736.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-20"}}, "5238": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-15"}}, "584": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"195": {"$update": {"dna_sequence": {"$update": {"accession": "AY171244.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA21"}}, "585": {"$update": {"ARO_description": "NDM-7 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1183": {"$update": {"dna_sequence": {"$update": {"accession": "JX262694.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-7"}}, "763": {"$update": {"ARO_description": "catI is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"482": {"$update": {"dna_sequence": {"$update": {"accession": "V00622.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catI"}}, "583": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1542": {"$update": {"dna_sequence": {"$update": {"accession": "AM941846.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-100"}}, "580": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1566": {"$update": {"dna_sequence": {"$update": {"accession": "AY072920.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-110"}}, "581": {"$update": {"ARO_description": "QnrB19 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"484": {"$update": {"dna_sequence": {"$update": {"accession": "JX298080.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB19"}}, "5273": {"$insert": {"CARD_short_name": "PDC-136"}}, "1984": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1871": {"$update": {"dna_sequence": {"$update": {"accession": "JQ926986.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-144"}}, "588": {"$update": {"ARO_description": "OKP-A-7 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1750": {"$update": {"dna_sequence": {"$update": {"accession": "AM051146.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-7"}}, "589": {"$update": {"model_sequences": {"$update": {"sequence": {"8234": {"dna_sequence": {"partial": "0", "sequence": "ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCAGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTATGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCACGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAAGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "fmax": "861", "accession": "DQ105528.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAZ14083.2", "sequence": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLMRSALPAGWFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-145"}}, "1261": {"$insert": {"CARD_short_name": "rosA"}}, "1985": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1394": {"$update": {"dna_sequence": {"$update": {"accession": "U20270.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-7"}}, "5004": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-692"}}, "2839": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-18"}}, "2838": {"$update": {"ARO_description": "A plasmid-borne novel MCR-1 functional variant detected in a Klebsiella pneumoniae isolate collected from a rectal swab in Italy. MCR-1.2 differs from MCR-1 by a single amino acid substitution from Glutamine to Leucine at position 3 in the N-terminal region. Described by DiPilato et al. 2016."}, "$insert": {"CARD_short_name": "MCR-1.2"}}, "2837": {"$update": {"ARO_category": {"$update": {"36267": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''."}}}}}, "$insert": {"CARD_short_name": "APH(2'')-If"}}, "2836": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4187": {"$update": {"dna_sequence": {"$update": {"accession": "AY453162.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Bla2"}}, "2835": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems)."}, "$insert": {"CARD_short_name": "PatA-PatB"}}, "2834": {"$update": {"ARO_category": {"$update": {"41263": {"$update": {"category_aro_description": "Point mutations occurring in the iniB region of the iniBAC operon shown to confer resistance to ethambutol."}}}}}, "$insert": {"CARD_short_name": "Mtub_iniB_EMB"}}, "2833": {"$update": {"ARO_description": "Point mutation in B. hyodysenteriae 23S rRNA shown to confer resistance to tylosin and erythromycin."}, "$insert": {"CARD_short_name": "Bhyo_23S_TYL"}}, "2832": {"$update": {"ARO_description": "AAC(2')-Ie is a chromosomal-encoded aminoglycoside acetyltransferase in M. leprae."}, "$insert": {"CARD_short_name": "AAC(2')-Ie"}}, "2831": {"$update": {"model_name": "rpoB2"}, "$insert": {"CARD_short_name": "rpoB2"}}, "1983": {"$update": {"ARO_description": "Also known as vanTN, is a vanT variant found in the vanN gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"259": {"$update": {"dna_sequence": {"$update": {"accession": "JF802084.1"}}}}}}}}, "model_name": "vanT gene in vanN cluster", "ARO_name": "vanT gene in vanN cluster"}, "$insert": {"CARD_short_name": "vanT_in_vanN_cl"}}, "1436": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1247": {"$update": {"dna_sequence": {"$update": {"accession": "FR717535.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-40"}}, "1437": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"700": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}, "model_name": "AcrF", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "AcrF"}}, "5405": {"$insert": {"CARD_short_name": "PDC-270"}}, "5404": {"$insert": {"CARD_short_name": "PDC-268"}}, "1432": {"$update": {"ARO_description": "Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance.", "model_sequences": {"$update": {"sequence": {"8264": {"dna_sequence": {"partial": "0", "sequence": "ATGGCTACCGAAGCCGCCCCACCCCGTATCGCCGTCCGGCTACCATCTACCTCCGTGCGCGACGCGGGAGCAAACTACCGGATCGCCCGGTACGTCGCTGTGGTGGCGGGTCTGCTAGGCGCTGTGCTGGCCATCGCCACCCCACTGCTGCCGGTCAACCAGACCACCGCGCAATTGAACTGGCCCCAAAACGGCACGTTCGCCAGTGTCGAGGCACCGCTGATTGGCTACGTGGCCACCGACTTGAACATCACCGTCCCCTGCCAGGCCGCCGCCGGACTGGCCGGATCGCAGAACACCGGCAAGACGGTGTTGTTGTCAACGGTGCCCAAGCAGGCGCCTAAGGCCGTCGATCGCGGGCTGCTGCTGCAACGGGCCAACGACGACCTGGTGCTTGTGGTGCGTAATGTCCCGTTGGTCACCGCCCCGCTGAGTCAGGTGCTCGGCCCGACCTGTCAGCGGTTGACATTCACCGCGCACGCCGATCGGGTCGCCGCCGAATTCGTCGGACTGGTGCAGGGACCCAATGCTGAGCACCCCGGTGCACCGCTGCGCGGTGAGCGCAGCGGCTACGACTTCCGCCCGCAGATCGTCGGGGTGTTCACCGACCTGGCCGGGCCGGCGCCACCGGGTCTGAGCTTCTCGGCGAGCGTGGATACCCGCTACAGCAGCAGCCCCACGCCGCTGAAGATGGCCGCCATGATCCTCGGGGTAGCGCTCACCGGCGCCGCCCTGGTGGCGCTGCACATCCTGGACACCGCCGACGGCATGCGGCACCGGCGGTTCCTGCCCGCGCGCTGGTGGTCGACCGGCGGTCTGGACACCCTGGTTATCGCCGTGCTGGTGTGGTGGCATTTCGTCGGGGCCAACACCTCCGACGACGGCTACATCCTGACCATGGCCCGGGTGTCCGAGCATGCGGGCTATATGGCCAACTACTACCGCTGGTTCGGCACACCCGAGGCGCCTTTCGGCTGGTACTACGACCTGCTGGCGCTGTGGGCTCATGTCAGCACGGCCAGTATCTGGATGCGCCTACCCACCCTGGCGATGGCGCTCACCTGCTGGTGGGTAATCAGCCGTGAGGTCATTCCCCGGCTGGGGCACGCCGTCAAGACGAGCCGGGCAGCGGCGTGGACGGCGGCGGGCATGTTTCTGGCTGTCTGGCTGCCGCTGGACAACGGCCTTCGGCCCGAGCCGATCATCGCCCTGGGCATCCTGCTGACCTGGTGCTCGGTGGAGCGGGCGGTGGCCACCAGCCGGCTGCTGCCGGTGGCAATCGCCTGCATCATCGGTGCCTTGACCCTGTTCTCCGGGCCGACGGGCATCGCCTCGATCGGTGCGCTGCTGGTCGCGATCGGGCCGCTACGGACCATCCTGCACCGGCGTTCCAGGCGGTTCGGCGTGCTACCACTGGTGGCGCCGATCCTGGCCGCGGCCACCGTCACCGCGATCCCGATCTTTCGTGATCAGACCTTCGCGGGCGAGATCCAGGCCAACCTCCTCAAGCGTGCCGTAGGGCCCAGCCTGAAGTGGTTCGACGAACACATCCGCTACGAGCGGCTGTTCATGGCCAGCCCCGACGGCTCGATCGCCCGCCGCTTCGCCGTGCTGGCCTTGGTGCTGGCGCTCGCGGTATCGGTGGCAATGTCGTTACGTAAGGGCCGCATTCCAGGTACCGCTGCTGGACCGAGCCGCCGCATCATCGGCATCACGATCATTTCCTTCCTCGCGATGATGTTCACCCCGACAAAGTGGACCCATCACTTCGGGGTGTTCGCGGGGTTGGCCGGGTCGCTGGGGGCGCTTGCCGCGGTCGCGGTGACGGGCGCTGCGATGCGCTCGCGGCGGAACCGGACCGTGTTCGCCGCCGTGGTGGTCTTCGTGTTGGCCCTGTCGTTCGCCAGTGTCAACGGCTGGTGGTACGTGTCCAACTTCGGTGTGCCATGGTCGAACTCGTTTCCGAAGTGGCGATGGTCGCTTACCACCGCACTCCTCGAGCTGACGGTGCTGGTGCTGCTGCTAGCGGCATGGTTCCACTTCGTCGCCAACGGTGACGGGCGCCGAACAGCCAGGCCAACCCGGTTTAGGGCACGACTAGCCGGAATTGTCCAGTCCCCGTTGGCAATTGCCACGTGGTTGCTGGTGCTTTTCGAGGTGGTATCGCTGACCCAGGCGATGATTTCCCAGTACCCGGCGTGGTCGGTTGGCCGGTCTAACCTACAGGCTTTGGCCGGCAAGACCTGCGGGCTGGCCGAAGACGTGCTGGTGGAGCTGGATCCCAACGCAGGCATGCTGGCGCCGGTGACCGCGCCGTTGGCCGACGCCCTGGGAGCCGGCCTGTCTGAAGCCTTCACACCCAACGGCATTCCCGCCGACGTCACCGCCGACCCGGTGATGGAACGTCCAGGGGATCGCAGTTTCCTCAACGACGACGGGCTGATCACCGGCAGCGAACCCGGCACCGAAGGGGGCACCACGGCCGCACCGGGAATCAACGGCTCCCGCGCCCGGCTGCCCTACAACCTGGACCCGGCCCGTACACCGGTGCTGGGCAGCTGGCGAGCCGGCGTGCAGGTGCCCGCCATGCTGCGGTCGGGCTGGTACCGGCTGCCCACCAACGAGCAGCGGGACAGGGCGCCGCTGCTGGTGGTGACGGCGGCCGGGCGATTCGACTCCCGCGAGGTCCGGTTGCAGTGGGCCACCGACGAGCAAGCGGCCGCCGGACACCACGGTGGGTCGATGGAATTCGCCGACGTCGGTGCCGCGCCGGCCTGGCGCAACCTGCGCGCACCACTGTCCGCCATCCCGAGCACCGCCACCCAGGTCCGGTTGGTCGCCGACGACCAGGATCTGGCGCCGCAGCACTGGATCGCCCTCACACCACCGCGGATTCCGCGGGTGCGCACGCTGCAGAACGTGGTGGGCGCAGCGGATCCGGTGTTCCTGGACTGGCTGGTGGGGCTGGCATTCCCCTGCCAACGCCCGTTCGGCCACCAATACGGCGTCGACGAGACACCCAAGTGGCGGATCCTGCCGGACCGGTTCGGCGCCGAAGCCAACTCACCGGTGATGGATCACAATGGCGGTGGCCCGCTGGGCATCACCGAGCTGCTGATGCGCGCAACCACGGTGGCCAGCTACCTCAAAGACGACTGGTTTAGGGACTGGGGCGCGTTACAGCGGTTGACGCCTTACTACCCCGACGCCCAGCCCGCTGATCTGAACCTAGGAACGGTGACTCGCAGCGGGCTGTGGAGTCCGGCGCCGTTGCGCCGCGGCTAG", "fmax": "4243325", "accession": "CP003248.2", "fmin": "4240040", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332", "NCBI_taxonomy_cvterm_id": "39507"}, "protein_sequence": {"accession": "AFN51819.1", "sequence": "MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLAIATPLLPVNQTTAQLNWPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGKTVLLSTVPKQAPKAVDRGLLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAHADRVAAEFVGLVQGPNAEHPGAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASVDTRYSSSPTPLKMAAMILGVALTGAALVALHILDTADGMRHRRFLPARWWSTGGLDTLVIAVLVWWHFVGANTSDDGYILTMARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVSTASIWMRLPTLAMALTCWWVISREVIPRLGHAVKTSRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATSRLLPVAIACIIGALTLFSGPTGIASIGALLVAIGPLRTILHRRSRRFGVLPLVAPILAAATVTAIPIFRDQTFAGEIQANLLKRAVGPSLKWFDEHIRYERLFMASPDGSIARRFAVLALVLALAVSVAMSLRKGRIPGTAAGPSRRIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSLGALAAVAVTGAAMRSRRNRTVFAAVVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWSLTTALLELTVLVLLLAAWFHFVANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEVVSLTQAMISQYPAWSVGRSNLQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAGLSEAFTPNGIPADVTADPVMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLPYNLDPARTPVLGSWRAGVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQWATDEQAAAGHHGGSMEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIALTPPRIPRVRTLQNVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEANSPVMDHNGGGPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTVTRSGLWSPAPLRRG"}}}}}, "model_name": "Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol"}, "$insert": {"CARD_short_name": "Mtub_embC_EMB"}}, "1433": {"$update": {"ARO_description": "CMY-18 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1974": {"$update": {"dna_sequence": {"$update": {"accession": "AY743434.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-18"}}, "1430": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1942": {"$update": {"dna_sequence": {"$update": {"accession": "GQ390807.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-125"}}, "1431": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"771": {"$update": {"dna_sequence": {"$update": {"accession": "GU208678.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-15"}}, "3399": {"$update": {"ARO_description": "aadA8b is an aminoglycoside nucleotidyltransferase gene encoded by plasmids in E. coli; can be created by a recombination event  between aadA1 and aadA2.", "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA8b"}}, "418": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"888": {"$update": {"dna_sequence": {"$update": {"accession": "KF203099.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-325"}}, "1981": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3277": {"$update": {"dna_sequence": {"$update": {"accession": "M97297.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanA"}}, "5154": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-857"}}, "1438": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1147": {"$update": {"dna_sequence": {"$update": {"accession": "AF117743.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-19"}}, "1439": {"$update": {"model_sequences": {"$update": {"sequence": {"8142": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCACAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM176555.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47135.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPTGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-80"}}, "1260": {"$update": {"ARO_description": "APH(3')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in Niallia circulans.", "model_sequences": {"$update": {"sequence": {"$update": {"237": {"$update": {"dna_sequence": {"$update": {"accession": "X03364.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Niallia circulans"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-IVa"}}, "5230": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-946"}}, "5231": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-947"}}, "1349": {"$update": {"ARO_description": "IND-2a is a beta-lactamase found in Chryseobacterium indologenes.", "model_sequences": {"$update": {"sequence": {"$update": {"838": {"$update": {"dna_sequence": {"$update": {"accession": "AF219130.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-2a"}}, "5232": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-948"}}, "3284": {"$insert": {"CARD_short_name": "tet(48)"}}, "1541": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1176": {"$update": {"dna_sequence": {"$update": {"accession": "JX440354.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-14"}}, "4260": {"$insert": {"CARD_short_name": "ADC-195"}}, "459": {"$update": {"ARO_description": "CTX-M-94 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"788": {"$update": {"dna_sequence": {"$update": {"accession": "HM167760.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-94"}}, "4262": {"$insert": {"CARD_short_name": "ADC-197"}}, "4263": {"$insert": {"CARD_short_name": "ADC-198"}}, "4264": {"$insert": {"CARD_short_name": "ADC-199"}}, "4265": {"$insert": {"CARD_short_name": "ADC-200"}}, "4266": {"$insert": {"CARD_short_name": "ADC-201"}}, "4267": {"$insert": {"CARD_short_name": "ADC-202"}}, "450": {"$update": {"ARO_description": "OXA-51 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"8229": {"dna_sequence": {"partial": "0", "sequence": "ATGAACATTAAAACACTCTTACTTATAACAAGCGCTATTTTTATTTCAGCCTGCTCACCTTATATAGTGACTGCTAATCCAAATCACAGCGCTTCAAAATCTGATGAAAAAGCAGAGAAAATTAAAAATTTATTTAACGAAGTACACACTACGGGTGTTTTAGTTATCCAACAAGGCCAAACTCAACAAAGCTATGGTAATGATCTTGCTCGTGCTTCGACCGAGTATGTACCTGCTTCGACCTTCAAAATGCTTAATGCTTTGATCGGCCTTGAGCACCATAAGGCAACCACCACAGAAGTATTTAAGTGGGACGGGCAAAAAAGGCTATTCCCAGAATGGGAAAAGGACATGACCCTAGGCGATGCTATGAAAGCTTCCGCTATTCCGGTTTATCAAGATTTAGCTCGTCGTATTGGACTTGAACTCATGTCTAAGGAAGTGAAGCGTGTTGGTTATGGCAATGCAGATATCGGTACCCAAGTCGATAATTTTTGGCTGGTGGGTCCTTTAAAAATTACTCCTCAGCAAGAGGCACAGTTTGCTTACAAGCTAGCTAATAAAACGCTTCCATTTAGCCCAAAAGTCCAAGATGAAGTGCAATCCATGTTATTCATAGAAGAAAAGAATGGAAATAAAATATACGCAAAAAGTGGTTGGGGATGGGATGTAGACCCACAAGTAGGCTGGTTAACTGGATGGGTTGTTCAGCCTCAAGGAAATATTGTAGCGTTCTCCCTTAACTTAGAAATGAAAAAAGGAATACCTAGCTCTGTTCGAAAAGAGATTACTTATAAAAGTTTAGAACAATTAGGTATTTTATAG", "fmax": "825", "accession": "AJ309734.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "CAC83905.2", "sequence": "MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-51"}}, "1341": {"$update": {"ARO_description": "OXA-53 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"812": {"$update": {"dna_sequence": {"$update": {"accession": "AY289608.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-53"}}, "1342": {"$update": {"ARO_description": "Plasmid-encoded cat, or pp-cat, is a plasmid-encoded variant of the cat gene found in Photobacterium damselae subsp. piscicida.", "model_sequences": {"$update": {"sequence": {"$update": {"486": {"$update": {"dna_sequence": {"$update": {"accession": "D16171.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}, "model_name": "Plasmid-encoded cat (pp-cat)", "ARO_name": "Plasmid-encoded cat (pp-cat)"}, "$insert": {"CARD_short_name": "pp_cat"}}, "1343": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1292": {"$update": {"dna_sequence": {"$update": {"accession": "HM488987.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-166"}}, "1344": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}, "model_name": "MexH"}, "$insert": {"CARD_short_name": "MexH"}}, "455": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"150": {"$update": {"dna_sequence": {"$update": {"accession": "AF162694.1"}}}}}}}}, "ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanC"}}, "1346": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1950": {"$update": {"dna_sequence": {"$update": {"accession": "EF373970.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-94"}}, "457": {"$update": {"ARO_description": "OXA-93 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1428": {"$update": {"dna_sequence": {"$update": {"accession": "DQ519087.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-93"}}, "4466": {"$insert": {"CARD_short_name": "CMH-4"}}, "318": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1688": {"$update": {"dna_sequence": {"$update": {"accession": "KF421161.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-358"}}, "5236": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-13"}}, "1082": {"$update": {"ARO_description": "CTX-M-7 is a beta-lactamase found in Salmonella typhimurium.", "model_sequences": {"$update": {"sequence": {"$update": {"1432": {"$update": {"dna_sequence": {"$update": {"accession": "AJ005045.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-7"}}, "5237": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-14"}}, "4464": {"$insert": {"CARD_short_name": "CMH-2"}}, "517": {"$update": {"ARO_description": "QnrD2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"33": {"$update": {"dna_sequence": {"$update": {"accession": "KJ158441.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrD2"}}, "5548": {"$insert": {"CARD_short_name": "PDC-419"}}, "4465": {"$insert": {"CARD_short_name": "CMH-3"}}, "3263": {"$update": {"ARO_description": "A dihydrofolate reductase and trimethoprim resistance gene identified from non-typhoidal multidrug-resistant Salmonella enterica."}, "$insert": {"CARD_short_name": "dfrA32"}}, "3259": {"$update": {"ARO_description": "A dihydrofolate reductase and trimethoprim resistance gene from Aeromonas hydrophilia."}, "$insert": {"CARD_short_name": "dfrA28"}}, "5542": {"$insert": {"CARD_short_name": "PDC-412"}}, "1907": {"$update": {"ARO_description": "Also known as vanSA, is a vanS variant found in the vanA gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3276": {"$update": {"dna_sequence": {"$update": {"accession": "M97297.1"}}}}}}}}, "model_name": "vanS gene in vanA cluster", "ARO_name": "vanS gene in vanA cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanA_cl"}}, "5540": {"$insert": {"CARD_short_name": "PDC-410"}}, "5541": {"$insert": {"CARD_short_name": "PDC-411"}}, "5546": {"$insert": {"CARD_short_name": "PDC-417"}}, "5547": {"$insert": {"CARD_short_name": "PDC-418"}}, "5544": {"$insert": {"CARD_short_name": "PDC-415"}}, "1882": {"$update": {"ARO_description": "OXA-80 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1768": {"$update": {"dna_sequence": {"$update": {"accession": "EU019535.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-80"}}, "656": {"$update": {"ARO_description": "OXA-219 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1528": {"$update": {"dna_sequence": {"$update": {"accession": "JN215211.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-219"}}, "3940": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6303": {"$update": {"dna_sequence": {"$update": {"accession": "KP207589.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-130"}}, "654": {"$update": {"ARO_description": "dfrA26 is an integron-encoded dihydrofolate reductase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"111": {"$update": {"dna_sequence": {"$update": {"accession": "AM403715.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA26"}}, "655": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1928": {"$update": {"dna_sequence": {"$update": {"accession": "JX206446.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-243"}}, "652": {"$update": {"ARO_description": "tcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens.", "model_sequences": {"$update": {"sequence": {"$update": {"332": {"$update": {"dna_sequence": {"$update": {"accession": "D38215.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tcr3"}}, "653": {"$update": {"ARO_description": "AAC(3)-VIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces rimosus.", "model_sequences": {"$update": {"sequence": {"$update": {"694": {"$update": {"dna_sequence": {"$update": {"accession": "M22999.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(3)-VIIa"}}, "650": {"$update": {"ARO_description": "ANT(3'')-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons, integrons in Enterobacteriaceae, A. baumannii, P. aeruginosa and Vibrio cholerae.", "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA"}}, "1505": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"459": {"$update": {"dna_sequence": {"$update": {"accession": "U01945.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SAT-4"}}, "1508": {"$update": {"ARO_description": "QnrA2 is a plasmid-mediated quinolone resistance protein found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"465": {"$update": {"dna_sequence": {"$update": {"accession": "HQ449669.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrA2"}}, "1509": {"$update": {"ARO_description": "Also known as vanXF, is a vanX variant found in the vanF gene cluster.", "model_sequences": {"$update": {"sequence": {"8203": {"dna_sequence": {"partial": "0", "sequence": "ATGGAAAAAGATTTTGTTTTTTTAGATGAAATATTGCATGGAGTTCGTTGGGACTCCAAATATGCCACATGGGACAATTTCACTGGAAAACCGGTAGACGGATATGAAGTCAATCGCATAGCGGGGACATATGCTTTGGCTGTTGCGCTGCTGGAGGTAAAGAAGCAGGCGGCTGCTCTAGGGTACGGCTTGCTCCTGTGGGATGGCTATCGTCCTCAACGTGCGGTAAACTGTTTCTTGCATTGGTCTGCGCAGCCGGAAGACGGCCGCACAAAAGAAAGATATTATCCCAATATTGATCGGATCGAGATGGTTACAAAGGGATATGTGGCTTCAAAATCAAGCCACAGTCGCGGAAGCGCGATTGACCTTACGCTTTATCGATTGGACACGGGTGCGCTTGTCCCTATGGGGAGCGGCTTCGATTTTATGGATGAACGTTCACATCATACCTCAAAAGGAATTTCAAGTAACGAAGCGCAAAATCGCCAGTTATTATGTTCTATTATGGAATACAGCGGATTTGAATCATATGTATATGAATGGTGGCACTACGTATTAAGAAACGAACCATACCCCAGCAGCTATTTTGATTTTCCCATTGGCGGGAACCATCTAGACCCATTTTCCAACTTTTGTGGGACAGTGCCACTTGATGCGTTGTCGCCCTAA", "fmax": "7648", "accession": "AF155139.2", "fmin": "6976", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Paenibacillus popilliae ATCC 14706", "NCBI_taxonomy_id": "1212764", "NCBI_taxonomy_cvterm_id": "39542"}, "protein_sequence": {"accession": "AAF36804.1", "sequence": "MEKDFVFLDEILHGVRWDSKYATWDNFTGKPVDGYEVNRIAGTYALAVALLEVKKQAAALGYGLLLWDGYRPQRAVNCFLHWSAQPEDGRTKERYYPNIDRIEMVTKGYVASKSSHSRGSAIDLTLYRLDTGALVPMGSGFDFMDERSHHTSKGISSNEAQNRQLLCSIMEYSGFESYVYEWWHYVLRNEPYPSSYFDFPIGGNHLDPFSNFCGTVPLDALSP"}}}}}, "model_name": "vanX gene in vanF cluster", "ARO_name": "vanX gene in vanF cluster"}, "$insert": {"CARD_short_name": "vanX_in_vanF_cl"}}, "3942": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6305": {"$update": {"dna_sequence": {"$update": {"accession": "KT997883.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-138"}}, "658": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1546": {"$update": {"dna_sequence": {"$update": {"accession": "KF150216.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-104"}}, "516": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4556": {"$update": {"dna_sequence": {"$update": {"accession": "AP009048.1"}}}}}}}}}, "$insert": {"CARD_short_name": "eptA"}}, "3943": {"$update": {"ARO_description": "Novel mcr-3.41 gene identified in an Aeromonas veronii C198 isolate from a patient with Septicemia in Thailand by Hatrongjit et. al."}, "$insert": {"CARD_short_name": "mcr-3.41"}}, "3369": {"$update": {"ARO_description": "Subtype of FosB, fosfomycin resistant. S.aureus SA1129 carried a FosB1 identical to S. haemolyticus."}, "$insert": {"CARD_short_name": "FosB1"}}, "317": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1954": {"$update": {"dna_sequence": {"$update": {"accession": "AM087454.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-148"}}, "3945": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 04-AUG-2016.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-194"}}, "3946": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-220"}}, "5684": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-23"}}, "314": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1324": {"$update": {"dna_sequence": {"$update": {"accession": "GU550123.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-176"}}, "2124": {"$insert": {"CARD_short_name": "Cdif_EFTu_ELF"}}, "1992": {"$update": {"ARO_description": "dfrA1 is an integron-encoded dihydrofolate reductase."}, "$insert": {"CARD_short_name": "dfrA1"}}, "3884": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-818"}}, "3887": {"$insert": {"CARD_short_name": "dfrA35"}}, "3886": {"$insert": {"CARD_short_name": "FosA7.5"}}, "3881": {"$insert": {"CARD_short_name": "PDC-28"}}, "4918": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-592"}}, "3883": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-668"}}, "3882": {"$insert": {"CARD_short_name": "PDC-41"}}, "1247": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1346": {"$update": {"dna_sequence": {"$update": {"accession": "JX440352.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-72"}}, "4919": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-593"}}, "3888": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6215": {"$update": {"dna_sequence": {"$update": {"accession": "AJ311171.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Tet(X1)"}}, "2129": {"$update": {"ARO_description": "Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"3240": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin"}, "$insert": {"CARD_short_name": "Ecol_16rrsB_SPT"}}, "4917": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-591"}}, "4935": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-609"}}, "5279": {"$insert": {"CARD_short_name": "PDC-142"}}, "1884": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1740": {"$update": {"dna_sequence": {"$update": {"accession": "JF274243.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-111"}}, "2815": {"$insert": {"CARD_short_name": "Mkan_23S_CLR"}}, "4915": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-589"}}, "4863": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-528"}}, "752": {"$update": {"ARO_description": "Also known as vanRM, is a vanR variant found in the vanM gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"337": {"$update": {"dna_sequence": {"$update": {"accession": "FJ349556.1"}}}}}}}}, "model_name": "vanR gene in vanM cluster", "ARO_name": "vanR gene in vanM cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanM_cl"}}, "4912": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-586"}}, "2788": {"$update": {"model_sequences": {"$update": {"sequence": {"8289": {"dna_sequence": {"partial": "0", "sequence": "ATGATGATTACTCTGCGCAAACTTCCTCTGGCGGTTGCCGTCGCAGCGGGCGTAATGTCTGCTCAGGCAATGGCTGTTGATTTCCACGGCTATGCACGTTCCGGTATTGGCTGGACAGGTAGCGGCGGTGAACAACAGTGTTTCCAGACTACCGGTGCTCAAAGTAAATACCGTCTTGGCAACGAATGTGAAACTTATGCTGAATTAAAATTGGGTCAGGAAGTGTGGAAAGAGGGCGATAAGAGCTTCTATTTCGACACTAACGTGGCCTATTCCGTCGCGCAACAGAATGACTGGGAAGCTACCGACCCGGCCTTCCGTGAAGCAAACGTGCAGGGTAAAAACCTGATCGAATGGCTGCCAGGCTCCACCATCTGGGCAGGTAAGCGCTTCTACCAACGTCATGACGTTCATATGATCGACTTCTACTACTGGGATATTTCTGGTCCTGGTGCCGGTCTGGAAAACATCGATGTTGGCTTCGGTAAACTCTCTCTGGCAGCAACCCGCTCCTCTGAAGCAGGTGGTTCTTCCTCTTTCGCCAGCAACAATATTTATGACTATACCAACGAAACCGCGAACGACGTTTTCGATGTGCGTTTAGCGCAGATGGAAGTCAACCCGGGCGGCACATTAGAACTGGGTGTCGACTACGGTCGTGCCAACCTGCGTGATAACTATCGTCTGGTTGATGGCGCATCGAAAGACGGCTGGTTATTCACTGCTGAACATACTCAGAGTGTCCTGAAGGGCTTTAACAAGTTTGTTGTTCAGTACGCTACTGACTCGATGACCTCGCAGGGTAAAGGTCTGTCGCAGGGTTCTGGCGTTGCATTTGATAACGAAAAATTTGCCTACAATATCAACAACAACGGTCACATGCTGCGTATCCTCGACCACGGTGCGATCTCCATGGGCGACAACTGGGACATGATGTACGTGGGTATGTACCAGGATATCAACTGGGATAACGACAACGGCACCAAGTGGTGGACCGTCGGTATTCGCCCGATGTACAAGTGGACGCCAATCATGAGCACCGTGATGGAAATCGGCTACGACAACGTCGAATCCCAGCGCACCGGCGACAAGAACAATCAGTACAAAATTACCCTCGCACAACAATGGCAGGCTGGCGACAGCATCTGGTCACGCCCGGCTATTCGTGTCTTCGCAACCTACGCCAAGTGGGATGAGAAATGGGGTTACGACTACAACGGCGATAGCAAGGTTAACCCGAACTACGGCAAAGCCGTTCCTGCTGATTTCAACGGCGGCAGCTTCGGTCGTGGCGACAGCGACGAGTGGACCTTCGGTGCCCAGATGGAAATCTGGTGGTAA", "fmax": "5102712", "accession": "BA000007.3", "fmin": "5101371", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli O157:H7 str. Sakai", "NCBI_taxonomy_id": "386585", "NCBI_taxonomy_cvterm_id": "36747"}, "protein_sequence": {"accession": "BAB38442.1", "sequence": "MMITLRKLPLAVAVAAGVMSAQAMAVDFHGYARSGIGWTGSGGEQQCFQTTGAQSKYRLGNECETYAELKLGQEVWKEGDKSFYFDTNVAYSVAQQNDWEATDPAFREANVQGKNLIEWLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGLENIDVGFGKLSLAATRSSEAGGSSSFASNNIYDYTNETANDVFDVRLAQMEVNPGGTLELGVDYGRANLRDNYRLVDGASKDGWLFTAEHTQSVLKGFNKFVVQYATDSMTSQGKGLSQGSGVAFDNEKFAYNINNNGHMLRILDHGAISMGDNWDMMYVGMYQDINWDNDNGTKWWTVGIRPMYKWTPIMSTVMEIGYDNVESQRTGDKNNQYKITLAQQWQAGDSIWSRPAIRVFATYAKWDEKWGYDYNGDSKVNPNYGKAVPADFNGGSFGRGDSDEWTFGAQMEIWW"}}}}}, "ARO_category": {"$update": {"40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}}, "$insert": {"CARD_short_name": "Ecol_LamB"}}, "4665": {"$insert": {"CARD_short_name": "GRD33-1"}}, "943": {"$update": {"ARO_description": "Also known as vanUG, is a vanG variant found in the vanG gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"339": {"$update": {"dna_sequence": {"$update": {"accession": "DQ212986.1"}}}}}}}}, "model_name": "vanU gene in vanG cluster", "ARO_name": "vanU gene in vanG cluster"}, "$insert": {"CARD_short_name": "vanU_in_vanG_cl"}}, "5151": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-854"}}, "4910": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-584"}}, "4900": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-574"}}, "4911": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-585"}}, "1883": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2110": {"$update": {"dna_sequence": {"$update": {"accession": "KP050490.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-10"}}, "4008": {"$update": {"ARO_description": "PDC-284 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-284"}}, "4009": {"$update": {"ARO_description": "PDC-105 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-105"}}, "4860": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-525"}}, "1376": {"$update": {"ARO_description": "MOX-6 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1364": {"$update": {"dna_sequence": {"$update": {"accession": "GQ152601.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-6"}}, "1460": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"418": {"$update": {"dna_sequence": {"$update": {"accession": "HQ219726.1"}}}}}}}}}, "$insert": {"CARD_short_name": "FosB3"}}, "4000": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-237"}}, "4001": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-238"}}, "4002": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-240"}}, "4003": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-241"}}, "4004": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-242"}}, "4005": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-243"}}, "4006": {"$update": {"ARO_description": "PDC-225 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-225"}}, "4007": {"$update": {"ARO_description": "PDC-438 is class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-438"}}, "322": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"789": {"$update": {"dna_sequence": {"$update": {"accession": "Y17896.1"}}}}}}}}, "model_name": "FEZ-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FEZ-1"}}, "323": {"$update": {"ARO_description": "aadA9 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in C. glutamicum.", "model_sequences": {"$update": {"sequence": {"$update": {"4491": {"$update": {"dna_sequence": {"$update": {"accession": "DQ390458.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA9"}}, "320": {"$update": {"ARO_description": "PBP2x is a penicillin-binding protein found in Streptococcus pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"331": {"$update": {"dna_sequence": {"$update": {"accession": "JN645706.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40661": {"$update": {"category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}}}}}, "$insert": {"CARD_short_name": "Spne_PBP2x_AMX"}}, "321": {"$update": {"ARO_description": "CTX-M-35 is a beta-lactamase found in Citrobacter koseri.", "model_sequences": {"$update": {"sequence": {"$update": {"1106": {"$update": {"dna_sequence": {"$update": {"accession": "AB176534.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-35"}}, "326": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1837": {"$update": {"dna_sequence": {"$update": {"accession": "JN638887.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-225"}}, "327": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"911": {"$update": {"dna_sequence": {"$update": {"accession": "HQ874631.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-17"}}, "324": {"$update": {"ARO_description": "QnrB54 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"8200": {"dna_sequence": {"partial": "0", "sequence": "ATGGCACTGGCACTCGTTAGCGAAAAAATTGACAGAAACCGCTTCACCGGTGAGAAAATTGAAAATAGTACATTTTTTAACTGTGATTTTTCAGGTGCCGACCTGAGCGGCACTGAATTTATCGGCTGTCAGTTCTATGATCGTGAAAGCCAGAAAGGGTGCAATTTTAGTCGTGCGATGCTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAATGCCAGTGCGCTTGGCATTGAAATTCGCCACTGTCGTGCGCAAGGCGCAGATTTCCGCGGCGCAAGCTTTATGAATATGATCACTACTCGCACCTGGTTTTGTAGTGCATATATCACTAACACAAATCTAAGCTACGCCAATTTTTCGAAAGTCGTGCTGGAAAAGTGTGAGCTGTGGGAAAACCGTTGGATGGGTACCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCGACTTTCGACTGGCGAGCAGCAAACTTCACACATTGCGATCTGACCAATTCGGAGTTGGGTGACTTAGATATTCGGGGCGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCATCGTTGCTCATGGAACGTCTTGGCATCGCGATTATTGGCTAG", "fmax": "1231", "accession": "HE820727.2", "fmin": "586", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Citrobacter freundii", "NCBI_taxonomy_id": "546", "NCBI_taxonomy_cvterm_id": "36915"}, "protein_sequence": {"accession": "CCI51002.2", "sequence": "MALALVSEKIDRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGTQVLGATFSGSDLSGGEFSTFDWRAANFTHCDLTNSELGDLDIRGVDLQGVKLDNYQASLLMERLGIAIIG"}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB54"}}, "325": {"$update": {"ARO_description": "LEN-23 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8270": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCGGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTAGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGCTCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM850913.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12351.2", "sequence": "MRYVRLCVISLLATLPLAVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVLYLRDTPASMAERNQHIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-23"}}, "3979": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-32"}}, "3978": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-31"}}, "328": {"$update": {"ARO_description": "cmlA is a plasmid-encoded chloramphenicol exporter that is found in Salmonella typhimurium.", "model_sequences": {"$update": {"sequence": {"8282": {"dna_sequence": {"partial": "0", "sequence": "ATGGACATGTACTTGCCAGCAGTGCCGTTTATGCCAAACGCGCTTGGTACGACAGCGAGCACAATTCAGCTTACGCTGACAACGTACTTGGTCATGATTGGTGCCGGTCAGCTCTTGTTTGGACCGCTATCGGACCGACTGGGGCGCCGCCCCGTTCTACTGGGAGGTGGCCTCGCAAACGTTGTGGCGTCAATGGGCCTCGCTCTTACGTCATCGGCTGAAGTCTTTCTGGGGCTTCGGATTCTTCAGGCTTGTGGTGCCTCGGCGTGCCTTGTTTCCACATTTGCAACAGTACGTGACATTTACGCAGGTCGCGAGGAAAGTAATGTCATTTACGGCATACTCGGATCCATGCTGGCCATGGTCCCGGCGGTAGGCCCATTGCTCGGAGCGCTCGTCGACATGTGGCTTGGGTGGCGGGCTATCTTTGCGTTTCTAGGTTTGGGCATGATCGCTGCATCTGCAGCAGCGTGGCGATTCTGGCCTGAAACCCGGGTGCAACGAGTTGCGGGCTTGCAATGGTCGCAGCTGCTACTCCCCGTTAAGTGCCTGAACTTCTGGTTGTACACGTTGTGTTACGCCGCTGGAATGGGTAGCTTCTTCGTCTTTTTCTCCATTGCGCCCGGACTAATGATGGGCAGGCAAGGTGTGTCTCAGCTTGGCTTCAGCCTGCTGTTCGCCACAGTGGCAATTGCCATGGTGTTTACGGCTCGTTTTATGGGGCGTGTGATACCCAAGTGGGGCAGCCCAAGTGTCTTGCGAATGGGAATGGGATGCCTGATAGCTGGAGCAGTATTGCTTGCCATCACCGAAATATGGGCTTTGCAGTCCGTGTTAGGCTTTATTGCTCCAATGTGGCTAGTGGGTATTGGTGTCGCCACAGCGGTATCTGTGGCGCCCAATGGCGCTCTTCGAGGATTCGACCATGTTGCTGGAACGGTCACGGCAGTCTACTTCTGCTTGGGCGGTGTACTGCTAGGAAGCATCGGAACGTTGATCATTTCGCTGTTGCCGCGCAACACGGCTTGGCCGGTTGTCGTGTACTGTTTGACCCTTGCAACAGTCGTGCTCGGTCTGTCTTGTGTTTCCCGAGTGAAGGGCTCTCGCGGCCAGGGGGAGCATGATGTGGTCGCGCTACAAAGTGCGGGAAGTACATCAAATCCCAATCGTTGA", "fmax": "2858", "accession": "AJ487033.2", "fmin": "1685", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Typhimurium", "NCBI_taxonomy_id": "90371", "NCBI_taxonomy_cvterm_id": "35732"}, "protein_sequence": {"accession": "CAD31707.1", "sequence": "MDMYLPAVPFMPNALGTTASTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLGGGLANVVASMGLALTSSAEVFLGLRILQACGASACLVSTFATVRDIYAGREESNVIYGILGSMLAMVPAVGPLLGALVDMWLGWRAIFAFLGLGMIAASAAAWRFWPETRVQRVAGLQWSQLLLPVKCLNFWLYTLCYAAGMGSFFVFFSIAPGLMMGRQGVSQLGFSLLFATVAIAMVFTARFMGRVIPKWGSPSVLRMGMGCLIAGAVLLAITEIWALQSVLGFIAPMWLVGIGVATAVSVAPNGALRGFDHVAGTVTAVYFCLGGVLLGSIGTLIISLLPRNTAWPVVVYCLTLATVVLGLSCVSRVKGSRGQGEHDVVALQSAGSTSNPNR"}}}}}}, "$insert": {"CARD_short_name": "Sent_cmlA"}}, "329": {"$insert": {"CARD_short_name": "CTX-M-159"}}, "3365": {"$insert": {"CARD_short_name": "cmlA8"}}, "1904": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1419": {"$update": {"dna_sequence": {"$update": {"accession": "KM087835.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-32"}}, "3629": {"$update": {"ARO_description": "Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40661": {"$update": {"category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}}}}, "model_name": "Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics", "ARO_name": "Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics"}, "$insert": {"CARD_short_name": "Ngon_PBP1_BLA"}}, "3628": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "40661": {"$update": {"category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}}}}}, "$insert": {"CARD_short_name": "Ngon_PBP2_BLA"}}, "4942": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-616"}}, "758": {"$update": {"ARO_description": "OXA-198 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"8284": {"dna_sequence": {"partial": "0", "sequence": "ATGCATAAACACATGAGTAAGCTCTTCATCGCTTTTTTAGCCTTTCTGCTGTCGGTGCCAGCAGCCGCTGAAGACCAGACACTTGCCGAGCTCTTTGCCCAACAAGGCATTGACGGGACTATAGTGATTTCGTCGCTACACAACGGAAAGACATTTATCCACAACGATCCCCGCGCAAAACAGAGATTCTCGACAGCATCCACGTTCAAGATACTGAACACGCTGATCTCGCTCGAAGAAAAAGCCATCTCTGGAAAAGACGATGTGCTGAAATGGGACGGGCATATTTACGATTTTCCAGATTGGAATCGTGACCAGACGCTAGAAAGTGCGTTCAAGGTTTCCTGTGTCTGGTGTTATCAGGCGCTTGCACGCCAGGTCGGCGCGGAGAAGTATCGAAATTATTTACGCAAGTCAGTTTACGGAGAATTACGCGAGCCTTTTGAGGAAACAACATTCTGGCTTGATGGTTCACTTCAAATCAGCGCAATTGAACAAGTGAATTTCCTCAAGAAAGTTCATCTGCGCACTCTCCCATTCAGTGCATCGTCCTACGAAACGCTACGACAAATCATGCTTATCGAGCAAACGCCGGCTTTTACGCTGCGGGCCAAGACAGGCTGGGCAACAAGAGTAAAGCCGCAAGTTGGCTGGTATGTGGGCCATGTCGAAACTCCAACGGATGTATGGTTCTTTGCCACGAATATTGAAGTCCGTGACGAAAAAGACTTGCCCTTACGTCAGAAGCTAACGCGAAAAGCATTACAAGCAAAGGGGATCATCGAATAA", "fmax": "3801", "accession": "HQ634775.2", "fmin": "3012", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "ADT70779.1", "sequence": "MHKHMSKLFIAFLAFLLSVPAAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHNDPRAKQRFSTASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDWNRDQTLESAFKVSCVWCYQALARQVGAEKYRNYLRKSVYGELREPFEETTFWLDGSLQISAIEQVNFLKKVHLRTLPFSASSYETLRQIMLIEQTPAFTLRAKTGWATRVKPQVGWYVGHVETPTDVWFFATNIEVRDEKDLPLRQKLTRKALQAKGIIE"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-198"}}, "3621": {"$insert": {"CARD_short_name": "LAP-2"}}, "3620": {"$insert": {"CARD_short_name": "LAP-1"}}, "3623": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-25"}}, "3622": {"$update": {"ARO_description": "LEN-17 is a beta-lactamase found in Escherichia coli.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-17"}}, "3625": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-36"}}, "3624": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-35"}}, "1340": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mtrC"}}, "3626": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-37"}}, "5253": {"$insert": {"CARD_short_name": "PDC-115"}}, "5680": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-19"}}, "4406": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6781": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "BSU-1"}}, "4271": {"$insert": {"CARD_short_name": "ADC-206"}}, "1881": {"$update": {"model_sequences": {"$update": {"sequence": {"8355": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAAATTTATACTTCCTATATTCAGCATTTCTATTCTAGTTTCTCTCAGTGCATGTTCATCTATTAAAACTAAATCTGAAGATAATTTTCATATTTCTTCTCAGCAACATGAAAAAGCTATTAAAAGCTATTTTGATGAAGCTCAAACACAGGGTGTAATTATTATTAAAGAGGGTAAAAATCTTAGCACCTATGGTAATGCTCTTGCACGAGCAAATAAAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCTTTAATCGGGCTAGAAAATCATAAAGCAACAACAAATGAGATTTTCAAATGGGATGGTAAAAAAAGAACTTATCCTATGTGGGAGAAAGATATGACTTTAGGTGAGGCAATGGCATTGTCAGCAGTTCCAGTATATCAAGAGCTTGCAAGACGGACTGGCCTAGAGCTAATGCAGAAAGAAGTAAAGCGGGTTAATTTTGGAAATACAAATATTGGAACACAGGTCGATAATTTTTGGTTAGTTGGCCCCCTTAAAATTACACCAGTACAAGAAGTTAATTTTGCCGATGACCTTGCACATAACCGATTACCTTTTAAATTAGAAACTCAAGAAGAAGTTAAAAAAATGCTTCTAATTAAAGAAGTAAATGGTAGTAAGATTTATGCAAAAAGTGGATGGGGAATGGATGTTACTCCACAGGTAGGTTGGTTGACTGGTTGGGTGGAGCAAGCTAATGGAAAAAAAATCCCCTTTTCGCTCAACTTAGAAATGAAAGAAGGAATGTCTGGTTCTATTCGTAATGAAATTACTTATAAGTCGCTAGAAAATCTTGGAATCATTTAA", "fmax": "2033", "accession": "GU199039.2", "fmin": "1205", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "ADB28892.1", "sequence": "MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-72"}}, "4866": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-531"}}, "4714": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7089": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "KLUC-1"}}, "2331": {"$insert": {"CARD_short_name": "kdpE"}}, "4716": {"$insert": {"CARD_short_name": "KLUC-3"}}, "2333": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-26"}}, "2334": {"$insert": {"CARD_short_name": "ADC-1"}}, "2335": {"$insert": {"CARD_short_name": "ADC-2"}}, "2336": {"$insert": {"CARD_short_name": "ADC-3"}}, "4713": {"$update": {"ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-16"}}, "2338": {"$insert": {"CARD_short_name": "ADC-5"}}, "2339": {"$insert": {"CARD_short_name": "ADC-6"}}, "5429": {"$insert": {"CARD_short_name": "PDC-299"}}, "4718": {"$insert": {"CARD_short_name": "KLUC-5"}}, "4719": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-21"}}, "1596": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1607": {"$update": {"dna_sequence": {"$update": {"accession": "AF509241.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-24"}}, "1880": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"569": {"$update": {"dna_sequence": {"$update": {"accession": "KF147862.1"}}}}}}}}}, "$insert": {"CARD_short_name": "adeN"}}, "835": {"$update": {"ARO_description": "APH(3')-Ib is a plasmid-encoded aminoglycoside phosphotransferase in E. coli.", "model_sequences": {"$update": {"sequence": {"$update": {"329": {"$update": {"dna_sequence": {"$update": {"accession": "M20305.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-Ib"}}, "1593": {"$update": {"ARO_description": "CMY-99 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1860": {"$update": {"dna_sequence": {"$update": {"accession": "KF305673.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-99"}}, "1592": {"$update": {"ARO_description": "dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli."}, "$insert": {"CARD_short_name": "dfrA14"}}, "5682": {"$update": {"ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-21"}}, "4126": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-1d"}}, "3960": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-218"}}, "4478": {"$insert": {"CARD_short_name": "CMY-174"}}, "2711": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "MexXY-OprM"}}, "1278": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1495": {"$update": {"dna_sequence": {"$update": {"accession": "X95401.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-45"}}, "640": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3344": {"$update": {"dna_sequence": {"$update": {"accession": "AJ250203.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(31)"}}, "4471": {"$insert": {"CARD_short_name": "CMY-131"}}, "4470": {"$insert": {"CARD_short_name": "CMY-109"}}, "4473": {"$insert": {"CARD_short_name": "CMY-159"}}, "4472": {"$insert": {"CARD_short_name": "CMY-137"}}, "4475": {"$insert": {"CARD_short_name": "CMY-168"}}, "4474": {"$insert": {"CARD_short_name": "CMY-167"}}, "4477": {"$insert": {"CARD_short_name": "CMY-170"}}, "4476": {"$insert": {"CARD_short_name": "CMY-169"}}, "4909": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-583"}}, "4908": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-582"}}, "947": {"$update": {"model_sequences": {"$update": {"sequence": {"8236": {"dna_sequence": {"partial": "0", "sequence": "ATGAACATTAAAGCACTCTTACTTATAACAAGCACTATTTTTATTTCAGCCTGCTCACCTTATATAGTGACTGCTAATCCAAATCACAGCACTTCAAAATCTGATGAAAAAGCAGAGAAAATTAAAAATTTATTTAACGAAGCACACACTACGGGTGTTTTAGTTATCCAACAAGGCCAAACTCAACAAAGCTATGGTAATGATCTTGCTCGTGCTTCGACCGAGTATGTACCTGCTTCGACCTTCAAAATGCTTAATGCTTTGATCGGCCTTGAGCACCATAAGGCAACCACCACAGAAATATTTAAGTGGGACGGGCAAAAAAGGCTGTTCCCAGAATGGGAAAAGGACATGACCCTAGGTGATGCTATGAAAGCTTCCGCTATTCCGGTTTATCAAGATTTAGCTCGTCGTATTGGACTTGAACTCATGTCTAAGGAAGTGAAGCGTGTTGGTTATGGCAATGCAGATATCGGTACCCAAGTCGATAATTTTTGGCTGGTGGGTCCTTTAAAAATTACGCCTCAGCAAGAGGCACAATTTGCTTACAAGCTAGCTAATAAAACGCTTCCATTTAGCCAAAAAGTCCAAGATGAAGTGCAATCCATGCTATTCATAGAAGAAAAGAATGGAAATAAAATATACGCAAAAAGTGGTTGGGGATGGGATGTAGACCCACAAGTAGGCTGGTTAACTGGATGGGTTGTTCAGCCTCAAGGGAATATTGTAGCGTTCTCCCTTAACTTAGAAATGAAAAAAGGAATACCTAGCTCTGTTCGAAAAGAGATTACTTATAAAAGTTTAGAACAATTAGGTATTTTATAG", "fmax": "825", "accession": "AM231720.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "CAJ77817.2", "sequence": "MNIKALLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-100"}}, "4666": {"$insert": {"CARD_short_name": "IMI-12"}}, "4679": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-17"}}, "4678": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7053": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "IMI-9"}}, "4677": {"$insert": {"CARD_short_name": "IMI-6"}}, "4676": {"$insert": {"CARD_short_name": "IMI-5"}}, "4675": {"$insert": {"CARD_short_name": "IMI-21"}}, "4674": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7049": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "IMI-20"}}, "4673": {"$insert": {"CARD_short_name": "IMI-19"}}, "4672": {"$insert": {"CARD_short_name": "IMI-18"}}, "4671": {"$insert": {"CARD_short_name": "IMI-17"}}, "4906": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-580"}}, "3252": {"$insert": {"CARD_short_name": "Cjej_23S_ERY"}}, "2248": {"$insert": {"CARD_short_name": "fusD"}}, "2249": {"$update": {"ARO_description": "The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane."}, "$insert": {"CARD_short_name": "LpxA"}}, "2245": {"$update": {"ARO_description": "Also known as vanKI, is a peptidoglycan bridge formation protein also known as FemAB that is part of the vanI glycopeptide resistance gene cluster.", "ARO_category": {"$update": {"39349": {"$update": {"category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance."}}}}, "model_name": "vanK gene in vanI cluster", "ARO_name": "vanK gene in vanI cluster"}, "$insert": {"CARD_short_name": "vanK_in_vanI_cl"}}, "2246": {"$update": {"ARO_description": "Also known as vanRI, is the regulatory transcriptional activator in the vanSR regulator within the vanI glycopeptide resistance gene cluster.", "model_name": "vanR gene in vanI cluster", "ARO_name": "vanR gene in vanI cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanI_cl"}}, "2240": {"$insert": {"CARD_short_name": "vanJ"}}, "2241": {"$update": {"ARO_category": {"$update": {"39340": {"$update": {"category_aro_name": "Van ligase", "category_aro_description": "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity."}}}}}, "$insert": {"CARD_short_name": "vanI"}}, "2242": {"$update": {"ARO_description": "Also known as vanWI, is a vanW variant found in the vanI gene cluster.", "model_name": "vanW gene in vanI cluster", "ARO_name": "vanW gene in vanI cluster"}, "$insert": {"CARD_short_name": "vanW_in_vanI_cl"}}, "2243": {"$update": {"ARO_description": "Also known as vanXI, is a vanX variant found in the vanI glycopeptide resistance gene cluster. It is a D-Ala-D-Ala dipeptidase.", "model_name": "vanX gene in vanI cluster", "ARO_name": "vanX gene in vanI cluster"}, "$insert": {"CARD_short_name": "vanX_in_vanI_cl"}}, "1043": {"$update": {"model_sequences": {"$update": {"sequence": {"8230": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCGCCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGTGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGAAGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATCGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "891", "accession": "AM176551.2", "fmin": "30", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47131.2", "sequence": "MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVEDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-76"}}, "994": {"$update": {"model_sequences": {"$update": {"sequence": {"8138": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGCGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "891", "accession": "AM176552.2", "fmin": "30", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47132.2", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVALCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-77"}}, "997": {"$update": {"ARO_description": "VIM-31 is a beta-lactamase found in Enterobacter cloacae.", "model_sequences": {"$update": {"sequence": {"$update": {"1165": {"$update": {"dna_sequence": {"$update": {"accession": "JN982330.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-31"}}, "5178": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-881"}}, "991": {"$insert": {"CARD_short_name": "EreA"}}, "990": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1515": {"$update": {"dna_sequence": {"$update": {"accession": "JF896803.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-9"}}, "5148": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-851"}}, "992": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1150": {"$update": {"dna_sequence": {"$update": {"accession": "DQ174306.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-66"}}, "5146": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-848"}}, "4682": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-46"}}, "5144": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-845"}}, "5145": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-847"}}, "999": {"$update": {"ARO_description": "LEN-2 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1580": {"$update": {"dna_sequence": {"$update": {"accession": "AY037780.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LEN-2"}}, "998": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1231": {"$update": {"dna_sequence": {"$update": {"accession": "HM559945.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-134"}}, "5140": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-841"}}, "5141": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-842"}}, "120": {"$update": {"ARO_description": "aadA4 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Bordetella parapertussis and E. coli.", "model_sequences": {"$update": {"sequence": {"$update": {"408": {"$update": {"dna_sequence": {"$update": {"accession": "AY138986.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA4"}}, "121": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"286": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mdtF"}}, "122": {"$update": {"ARO_description": "VIM-34 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1408": {"$update": {"dna_sequence": {"$update": {"accession": "JX013656.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-34"}}, "123": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"992": {"$update": {"dna_sequence": {"$update": {"accession": "DQ174304.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-64"}}, "124": {"$update": {"ARO_description": "IND-7 is a beta-lactamase found in Chryseobacterium indologenes.", "model_sequences": {"$update": {"sequence": {"$update": {"1261": {"$update": {"dna_sequence": {"$update": {"accession": "AB529520.1"}}}}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-7"}}, "125": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2124": {"$update": {"dna_sequence": {"$update": {"accession": "KP050489.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-182"}}, "126": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1647": {"$update": {"dna_sequence": {"$update": {"accession": "HQ529916.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-183"}}, "127": {"$update": {"ARO_description": "clbB is a plasmid-encoded cfr gene found in Bacillus brevis.", "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "clbB"}}, "128": {"$update": {"ARO_description": "srmB is an ABC-F subfamily protein found in Streptomyces ambofaciens that confers resistance to spiramycin.", "model_sequences": {"$update": {"sequence": {"$update": {"189": {"$update": {"dna_sequence": {"$update": {"accession": "X63451.1"}}}}}}}}}, "$insert": {"CARD_short_name": "srmB"}}, "129": {"$insert": {"CARD_short_name": "FosX"}}, "945": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5150": {"$update": {"dna_sequence": {"$update": {"accession": "AM419751.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(40)"}}, "3385": {"$insert": {"CARD_short_name": "MCR-1.7"}}, "133": {"$update": {"ARO_description": "arr-8 is an integron-encoded ribosyltransferase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"682": {"$update": {"dna_sequence": {"$update": {"accession": "KC199968.1"}}}}}}}}}, "$insert": {"CARD_short_name": "arr-8"}}, "4877": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7252": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-548"}}, "4876": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-547"}}, "4871": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-537"}}, "4870": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-536"}}, "4873": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-542"}}, "132": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1571": {"$update": {"dna_sequence": {"$update": {"accession": "AB700703.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-198"}}, "2773": {"$insert": {"CARD_short_name": "TMB-1"}}, "5018": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-706"}}, "5343": {"$insert": {"CARD_short_name": "PDC-204"}}, "4879": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7254": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-550"}}, "4878": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7253": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-549"}}, "3254": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-11"}}, "2068": {"$update": {"ARO_description": "Point mutations in the 3' minor domain of the 16S rRNA in Escherichia coli can confer resistance to edeine.", "model_sequences": {"$update": {"sequence": {"$update": {"3234": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}}, "$insert": {"CARD_short_name": "Ecol_16S_EDN"}}, "3377": {"$update": {"ARO_description": "Aminoglycoside-resistance gene."}, "$insert": {"CARD_short_name": "rmtE"}}, "2798": {"$insert": {"CARD_short_name": "AxyZ"}}, "2799": {"$insert": {"CARD_short_name": "AxyY"}}, "3376": {"$update": {"ARO_description": "The first allele of a 16S rRNA methyltransferase gene, rmtD2, confers a high resistance to all clinically available aminoglycosides.", "model_sequences": {"$update": {"sequence": {"8349": {"dna_sequence": {"partial": "0", "sequence": "ATGAGCGAACTGAAGGAAAAACTGCTCGCTTCGAAAAAATATCGCGACGTTTGCCCGGACACGATCGAGCGCATATGGCGTGAATGCAGCGCGAAATTCAAAAAGGAAAAGGACGCGGACAAGGCGGCGCGCGAAGCGCTTCACGGTGTGACCGGCGCGTTCATGACCGAGCGCGAATACAAACGCGCGATGGAACTGGCGGCGACACGCGATTGGGAAGCGCTGCTTGGAATGCACGCGTCCACGCGCGAACGGCTGCCGGTGGAATCGATGGATCGCGTGTTCGATCAGCTGTTTGAAGCCATCGGAACGCCGGCGCGAATTCTCGATCTCGCGTGCGGGCTGAATCCGGTCTACCTCGCGCATCGATTGCCAAATGCGGCGATTGCCGGCGTGGATATCAGCGGTCAGTGCGTAAACGTAATTCGCGCGTTTGGCGGCGCGGAAGCGCGTTTGGGCGATTTGCTGTGCGAAATTCCGGAAGACGAAGCGGATGCGGCGCTGATGTTTAAGGTGCTGCCGCTTTTGGAGCGCCAGCGCACGGGCGCGGCGATGGAAGCGCTAATGCGTGTGAATGCGGAATGGATCGTCGCATCGTTTCCGACGCGTTCACTCGGCGGGCGCAACGTCGGCATGGAAAAGCACTATTCCGAATGGATGGAGGCGCACGTGCCGGAAAATCGCGCGATTGCCGCGCGGCTGACCGGCGAAAACGAGCTGTTTTACGTGCTGAAACGAAAATGA", "fmax": "14882", "accession": "HQ401565.1", "fmin": "14138", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella aerogenes", "NCBI_taxonomy_id": "548", "NCBI_taxonomy_cvterm_id": "36770"}, "protein_sequence": {"accession": "ADW66527.1", "sequence": "MSELKEKLLASKKYRDVCPDTIERIWRECSAKFKKEKDADKAAREALHGVTGAFMTEREYKRAMELAATRDWEALLGMHASTRERLPVESMDRVFDQLFEAIGTPARILDLACGLNPVYLAHRLPNAAIAGVDISGQCVNVIRAFGGAEARLGDLLCEIPEDEADAALMFKVLPLLERQRTGAAMEALMRVNAEWIVASFPTRSLGGRNVGMEKHYSEWMEAHVPENRAIAARLTGENELFYVLKRK"}}}}}}, "$insert": {"CARD_short_name": "rmtD2"}}, "2792": {"$insert": {"CARD_short_name": "Mcat_23S_MAC"}}, "2061": {"$update": {"ARO_description": "VIM-7 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1007": {"$update": {"dna_sequence": {"$update": {"accession": "AJ536835.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-7"}}, "2062": {"$insert": {"CARD_short_name": "mphC"}}, "2063": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4663": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Alkalihalobacillus clausii"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "41361": {"$update": {"category_aro_name": "BlaZ beta-lactamase", "category_aro_description": "BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus."}}}}}, "$insert": {"CARD_short_name": "blaR1"}}, "2064": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3690": {"$update": {"dna_sequence": {"$update": {"accession": "JQ034306.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-196"}}, "2065": {"$update": {"ARO_description": "CMY-5 is a beta-lactamase found in Klebsiella oxytoca."}, "$insert": {"CARD_short_name": "CMY-5"}}, "2066": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Ecol_soxS_MULT"}}, "2795": {"$update": {"model_name": "MCR-3.1"}, "$insert": {"CARD_short_name": "MCR-3.1"}}, "3374": {"$update": {"ARO_description": "Expression of cloned aphA15 gene in Escherichia coli reduced the susceptibility to kanamycin and neomycin, as well as to amikacin, netilmicin, and streptomycin.", "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "aphA15"}}, "3264": {"$update": {"ARO_description": "A dihydrofolate reductase and trimethoprim resistance gene identified on an integron in multidrug-resistant gram-negative bacteria.", "model_sequences": {"$update": {"sequence": {"8341": {"dna_sequence": {"partial": "0", "sequence": "ATGGACCAAGGTAGCAATGAAGTCGGTAATCCAGTTGCGGGCCAGTTTTCGTTCCCATCGAACGCCGCGTTTAGTATGGGAGATCGCGTGCGCAAGAAATCGGGCGCCGCTTGGCAAGGTCAGATTGTCGGGTGGTACTGCACAAAGTTGACCCCTGAAGGCTACGCTGTCGAGTCTGAGGCTCACCCTGGCTCGGTACAGATTTATCCTGTTGCGGCGCTTGAACGCATCAACGGAGTTCAAGGTTGA", "fmax": "1296", "accession": "GU295656.1", "fmin": "1047", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Aeromonas hydrophila", "NCBI_taxonomy_id": "644", "NCBI_taxonomy_cvterm_id": "36810"}, "protein_sequence": {"accession": "ADB54781.1", "sequence": "MDQGSNEVGNPVAGQFSFPSNAAFSMGDRVRKKSGAAWQGQIVGWYCTKLTPEGYAVESEAHPGSVQIYPVAALERINGVQG"}}}}}}, "$insert": {"CARD_short_name": "dfrB7"}}, "3410": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-124"}}, "2960": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-663"}}, "1182": {"$update": {"ARO_description": "CTX-M-105 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1184": {"$update": {"dna_sequence": {"$update": {"accession": "HQ833651.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-105"}}, "3411": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-125"}}, "3372": {"$update": {"ARO_description": "Fosfomycin resistance gene. High homology with FosB1 and FosB3."}, "$insert": {"CARD_short_name": "FosB6"}}, "3371": {"$update": {"ARO_description": "Fosfomycin resistance gene. High homology with FosB1 and FosB3."}, "$insert": {"CARD_short_name": "FosB5"}}, "4030": {"$update": {"ARO_description": "PDC-293 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-293"}}, "3370": {"$insert": {"CARD_short_name": "FosB4"}}, "2295": {"$insert": {"CARD_short_name": "Efac_liaF_DAP"}}, "1347": {"$update": {"ARO_description": "OXA-425 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem-resistant.", "model_sequences": {"$update": {"sequence": {"$update": {"1136": {"$update": {"dna_sequence": {"$update": {"accession": "KM588353.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-425"}}, "5099": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-794"}}, "3579": {"$insert": {"CARD_short_name": "CMY-135"}}, "3578": {"$update": {"ARO_description": "From Lahey's list of beta-lactamases, no additional information available."}, "$insert": {"CARD_short_name": "CMY-133"}}, "727": {"$update": {"ARO_description": "ErmS is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers two methyl groups. The gene is found within the tylosin biosynthetic cluster and is responsible for self-resistance.", "model_sequences": {"$update": {"sequence": {"$update": {"290": {"$update": {"dna_sequence": {"$update": {"accession": "M19269.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ErmS"}}, "3575": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CME-1"}}, "3574": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CKO-1"}}, "3577": {"$update": {"ARO_description": "From Lahey's list of beta-lactamases, no additional information available."}, "$insert": {"CARD_short_name": "CMY-132"}}, "3576": {"$insert": {"CARD_short_name": "CMH-1"}}, "3571": {"$insert": {"CARD_short_name": "CIA-2"}}, "3570": {"$insert": {"CARD_short_name": "CIA-1"}}, "3573": {"$insert": {"CARD_short_name": "CIA-4"}}, "5097": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-789"}}, "2666": {"$update": {"ARO_description": "fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid.", "ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "model_name": "Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan"}, "$insert": {"CARD_short_name": "Ecol_fabI_MULT"}}, "4496": {"$insert": {"CARD_short_name": "CTX-M-167"}}, "4495": {"$insert": {"CARD_short_name": "CTX-M-154"}}, "4494": {"$insert": {"CARD_short_name": "CTX-M-153"}}, "4493": {"$insert": {"CARD_short_name": "CTX-M-150"}}, "4492": {"$insert": {"CARD_short_name": "CTX-M-146"}}, "2660": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3995": {"$update": {"dna_sequence": {"$update": {"accession": "DQ679966.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Eclo_acrA"}}, "2661": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Ecol_acrA"}}, "940": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1489": {"$update": {"dna_sequence": {"$update": {"accession": "AY628176.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-125"}}, "4667": {"$insert": {"CARD_short_name": "IMI-13"}}, "2482": {"$update": {"model_name": "Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin"}, "$insert": {"CARD_short_name": "Crei_16rrnS_STR"}}, "4499": {"$insert": {"CARD_short_name": "CTX-M-170"}}, "4498": {"$insert": {"CARD_short_name": "CTX-M-169"}}, "5299": {"$insert": {"CARD_short_name": "PDC-160"}}, "3257": {"$update": {"ARO_description": "A dihydrofolate reductase and trimethoprim resistance gene identified from an integron in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"8340": {"dna_sequence": {"partial": "0", "sequence": "ATGGACCAAGGCAGAAGTGAAGTCAGTAATCCAGTTGCTGGCCAGTTTGCGTTCCCTTCAAACGCCGCGTTCGGAATGGGAGATCGCGTGCGCAAGAAATCTGGCGCCGCTTGGCAAGGCCAGATTGTCGGGTGGTACTGCACAAAATTGACCCCTGAAGGGTACGCTGTCGAGTCTGAGGCTCACCCTGGCTCGGTACAGATTTATCCTGTTGCGGCACTGGAACGCATCAACTGA", "fmax": "3092", "accession": "AY943084.1", "fmin": "2855", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AAX46054.1", "sequence": "MDQGRSEVSNPVAGQFAFPSNAAFGMGDRVRKKSGAAWQGQIVGWYCTKLTPEGYAVESEAHPGSVQIYPVAALERIN"}}}}}}, "$insert": {"CARD_short_name": "dfrB5"}}, "1397": {"$update": {"ARO_description": "dfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus."}, "$insert": {"CARD_short_name": "dfrC"}}, "5326": {"$insert": {"CARD_short_name": "PDC-187"}}, "5327": {"$insert": {"CARD_short_name": "PDC-188"}}, "5324": {"$insert": {"CARD_short_name": "PDC-185"}}, "5325": {"$insert": {"CARD_short_name": "PDC-186"}}, "5322": {"$insert": {"CARD_short_name": "PDC-182"}}, "5323": {"$insert": {"CARD_short_name": "PDC-184"}}, "5320": {"$insert": {"CARD_short_name": "PDC-180"}}, "5321": {"$insert": {"CARD_short_name": "PDC-181"}}, "3799": {"$insert": {"CARD_short_name": "LptD"}}, "5328": {"$insert": {"CARD_short_name": "PDC-189"}}, "1837": {"$update": {"ARO_description": "CTX-M-59 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1781": {"$update": {"dna_sequence": {"$update": {"accession": "DQ408762.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-59"}}, "1645": {"$update": {"ARO_description": "ACT-23 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1990": {"$update": {"dna_sequence": {"$update": {"accession": "KF515536.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-70"}}, "1647": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}, "model_name": "MexI"}, "$insert": {"CARD_short_name": "MexI"}}, "1646": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1322": {"$update": {"dna_sequence": {"$update": {"accession": "DQ072853.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-139"}}, "1641": {"$update": {"ARO_description": "OXA-203 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1527": {"$update": {"dna_sequence": {"$update": {"accession": "HQ998857.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-203"}}, "4875": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-546"}}, "1643": {"$insert": {"CARD_short_name": "arnA"}}, "1642": {"$update": {"ARO_description": "clbC is a plasmid-encoded cfr gene found in Alkalihalobacillus clausii.", "model_sequences": {"$update": {"sequence": {"$update": {"4249": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Alkalihalobacillus clausii KSM-K16"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "clbC"}}, "1396": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1522": {"$update": {"dna_sequence": {"$update": {"accession": "Z22590.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-11"}}, "1649": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1480": {"$update": {"dna_sequence": {"$update": {"accession": "KM087847.1"}}}}}}}}}, "$insert": {"CARD_short_name": "DHA-21"}}, "1648": {"$update": {"ARO_description": "CTX-M-2 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"8252": {"dna_sequence": {"partial": "0", "sequence": "ATGATGACTCAGAGCATTCGCCGCTCAATGTTAACGGTGATGGCGACGCTACCCCTGCTATTTAGCAGCGCAACGCTGCATGCGCAGGCGAACAGCGTGCAACAGCAGCTGGAAGCCCTGGAGAAAAGTTCGGGAGGTCGGCTTGGCGTTGCGCTGATTAACACCGCCGATAATTCGCAGATTCTCTACCGTGCCGATGAACGTTTTGCGATGTGCAGTACCAGTAAGGTGATGGCGGCCGCGGCGGTGCTTAAACAGAGCGAGAGCGATAAGCACCTGCTAAATCAGCGCGTTGAAATCAAGAAGAGCGACCTGGTTAACTACAATCCCATTGCGGAGAAACACGTTAACGGCACGATGACGCTGGCTGAGCTTGGCGCAGCGGCGCTGCAGTATAGCGACAATACTGCCATGAATAAGCTGATTGCCCATCTGGGTGGTCCCGATAAAGTGACGGCGTTTGCTCGCTCGTTGGGTGATGAGACCTTCCGTCTGGACAGAACCGAGCCCACGCTCAATACCGCCATTCCAGGCGACCCGCGTGATACCACCACGCCGCTCGCGATGGCGCAGACCCTGAAAAATCTGACGCTGGGTAAAGCGCTGGCGGAAACTCAGCGGGCACAGTTGGTGACGTGGCTTAAGGGCAATACTACCGGTAGCGCGAGCATTCGGGCGGGTCTGCCGAAATCATGGGTAGTGGGCGATAAAACCGGCAGCGGAGATTATGGCACCACCAACGATATCGCGGTTATCTGGCCGGAAAACCACGCACCGCTGGTTCTGGTGACCTACTTTACCCAACCGGAGCAGAAGGCGGAAAGCCGTCGGGATATTCTGGCTGCGGCGGCGAAAATCGTAACCCACGGTTTCTGA", "fmax": "7708", "accession": "DQ125241.2", "fmin": "6832", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAZ95872.1", "sequence": "MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-2"}}, "4228": {"$insert": {"CARD_short_name": "ADC-158"}}, "4864": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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PAS diminishes bacterial cell growth by limiting folic acid production."}}}}}, "$insert": {"CARD_short_name": "Mtub_folC_PAS"}}, "4360": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6735": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ALI-1"}}, "1421": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1405": {"$update": {"dna_sequence": {"$update": {"accession": "AJ277414.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-15"}}, "1422": {"$update": {"ARO_description": "ACC-3 is a beta-lactamase found in Hafnia alvei.", "model_sequences": {"$update": {"sequence": {"$update": {"1910": {"$update": {"dna_sequence": {"$update": {"accession": "AF180958.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACC-3"}}, "1425": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"356": {"$update": {"dna_sequence": {"$update": {"accession": "HQ203032.1"}}}}}}}}}, "$insert": {"CARD_short_name": "RbpA"}}, "1424": {"$update": {"ARO_description": "OXY-2-4 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"1384": {"$update": {"dna_sequence": {"$update": {"accession": "Y17714.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-2-4"}}, "1427": {"$insert": {"CARD_short_name": "acrD"}}, "1426": {"$update": {"ARO_description": "IMP-7 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1357": {"$update": {"dna_sequence": {"$update": {"accession": "AF318077.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-7"}}, "1429": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1948": {"$update": {"dna_sequence": {"$update": {"accession": "AB302939.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-60"}}, "1428": {"$update": {"ARO_description": "CphA2 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein.", "model_sequences": {"$update": {"sequence": {"$update": {"3364": {"$update": {"dna_sequence": {"$update": {"accession": "U60294.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cphA2"}}, "3366": {"$insert": {"CARD_short_name": "pexA"}}, "3367": {"$insert": {"CARD_short_name": "Saur_norA"}}, "3360": {"$update": {"ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catB11"}}, "4983": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7358": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-666"}}, "3362": {"$update": {"ARO_description": "The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein."}, "$insert": {"CARD_short_name": "Saur_FosB"}}, "3363": {"$update": {"ARO_description": "MCR-3.3 is a colistin resistance gene variant in the chromosome of an Aeromonas veronii. Conferred polymyxin resistance in both E. Coli and Aeromonas salmonicida."}, "$insert": {"CARD_short_name": "MCR-3.3"}}, "731": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1746": {"$update": {"dna_sequence": {"$update": {"accession": "AB074436.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-11"}}, "730": {"$update": {"ARO_description": "AAC(6')-IIc is an aminoglycoside acetyltransferase encoded by plasmids and integrons in E. cloacae.", "model_sequences": {"$update": {"sequence": {"$update": {"313": {"$update": {"dna_sequence": {"$update": {"accession": "AF162771.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-IIc"}}, "4883": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-554"}}, "938": {"$update": {"ARO_description": "QnrB70 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"370": {"$update": {"dna_sequence": {"$update": {"accession": "KC580659.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB70"}}, "735": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"930": {"$update": {"dna_sequence": {"$update": {"accession": "AJ437107.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-30"}}, "734": {"$update": {"ARO_description": "Also known as vanTC, is a vanT variant found in the vanC gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"151": {"$update": {"dna_sequence": {"$update": {"accession": "AF162694.1"}}}}}}}}, "model_name": "vanT gene in vanC cluster", "ARO_name": "vanT gene in vanC cluster"}, "$insert": {"CARD_short_name": "vanT_in_vanC_cl"}}, "736": {"$update": {"ARO_description": "arr-7 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"603": {"$update": {"dna_sequence": {"$update": {"accession": "FN397623.1"}}}}}}}}}, "$insert": {"CARD_short_name": "arr-7"}}, "739": {"$update": {"ARO_description": "LRA-18 is a beta-lactamase isolated from soil samples in Alaska.", "model_sequences": {"$update": {"sequence": {"$update": {"1673": {"$update": {"dna_sequence": {"$update": {"accession": "EU408355.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-18"}}, "738": {"$update": {"ARO_description": "AAC(6')-Iae is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa and S. enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"583": {"$update": {"dna_sequence": {"$update": {"accession": "AB104852.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iae"}}, "1217": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"966": {"$update": {"dna_sequence": {"$update": {"accession": "AM991978.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-139"}}, "3390": {"$update": {"ARO_description": "A plasmid-mediated MCR-3.1 variant."}, "$insert": {"CARD_short_name": "MCR-3.4"}}, "3304": {"$update": {"model_sequences": {"$update": {"sequence": {"8336": {"dna_sequence": {"partial": "0", "sequence": "GTGTCATCCAAAAATCAAGGCCGGCATGAGCACGGCCAGAATTTTCTGTGCGACCGTCGCGTGGTCGCCGACATCGTCAAAATCGTCTCGCACACAACAGGTTCCATCGTCGAGATCGGCGCCGGAGACGGTGCGCTGACCGTCCCGATGCAGCGGCTCGGGCGGCCGTTGACGGCCATCGAGATCGACCGTCGACGAGCAGAGCGCCTGGCTCGCCGTACCACGGCGCATGTCGTCACCGCCGATTTCCTGCGCTACCGCCTGCCACCCACCGAGCACGTGGTGGTGGGCAACCTGCCGTTCCACCTGACCACCGCGATTTTGCGGCGGCTGCTGCACAGCCCGGCATGGACCGACGCGGTGCTGCTCATGCAGTGGGAGGTGGCGCGCCGCCGCGCCGCGGTCGGCGGCGCAACGATGATGACCGCGCAGTGGTGGCCGTGGTTCGAATTCGGCTTGGCCCGTAAGGTTTCCGCCGACGCGTTCCGTCCCCGCCCGAGCGTGGACGCCGGGTTGCTGACCATCACGCGGCGCCGGGAACCGCTGATCGACGGCGCCGACCGCCGGCGCTACCAGGCGCTGGTCCATGCAGTGTTCACCGGGCGCGGCCGCGGTGTGGCGCAGATTGTGGGTCCACGAGTCCCGCGGCACTGGTTGCGCCACAACGGCATCACACCGTCGGCGCTGCCGAGGGATCTCACGGCCGCGCAGTGGGCAGCTCTGTTCGAGGTGACGAGCGAGGCGAAGCGGTGCTAG", "fmax": "2790", "accession": "AY570506.1", "fmin": "2034", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycolicibacterium mageritense", "NCBI_taxonomy_id": "53462", "NCBI_taxonomy_cvterm_id": "42568"}, "protein_sequence": {"accession": "AAS76623.1", "sequence": "MSSKNQGRHEHGQNFLCDRRVVADIVKIVSHTTGSIVEIGAGDGALTVPMQRLGRPLTAIEIDRRRAERLARRTTAHVVTADFLRYRLPPTEHVVVGNLPFHLTTAILRRLLHSPAWTDAVLLMQWEVARRRAAVGGATMMTAQWWPWFEFGLARKVSADAFRPRPSVDAGLLTITRRREPLIDGADRRRYQALVHAVFTGRGRGVAQIVGPRVPRHWLRHNGITPSALPRDLTAAQWAALFEVTSEAKRC"}}}}}}, "$insert": {"CARD_short_name": "erm(40)"}}, "4984": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-667"}}, "4273": {"$insert": {"CARD_short_name": "ADC-208"}}, "4272": {"$insert": {"CARD_short_name": "ADC-207"}}, "1359": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1209": {"$update": {"dna_sequence": {"$update": {"accession": "KJ657570.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-233"}}, "1358": {"$update": {"ARO_description": "VIM-24 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1806": {"$update": {"dna_sequence": {"$update": {"accession": "HM855205.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-24"}}, "469": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1067": {"$update": {"dna_sequence": {"$update": {"accession": "AY528718.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-49"}}, "468": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"582": {"$update": {"dna_sequence": {"$update": {"accession": "AL123456.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "Erm(37)"}}, "4275": {"$insert": {"CARD_short_name": "ADC-210"}}, "4274": {"$insert": {"CARD_short_name": "ADC-209"}}, "1353": {"$update": {"ARO_description": "GES-5 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1866": {"$update": {"dna_sequence": {"$update": {"accession": "AY494717.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-5"}}, "1352": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1375": {"$update": {"dna_sequence": {"$update": {"accession": "JN118546.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-251"}}, "467": {"$update": {"ARO_description": "CARB-3 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1506": {"$update": {"dna_sequence": {"$update": {"accession": "S46063.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-3"}}, "466": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1821": {"$update": {"dna_sequence": {"$update": {"accession": "AM982520.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-76"}}, "461": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1523": {"$update": {"dna_sequence": {"$update": {"accession": "U59183.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-13"}}, "1356": {"$update": {"ARO_description": "dfrA22 is an integron-encoded dihydrofolate reductase found in Salmonella enterica."}, "$insert": {"CARD_short_name": "dfrA22"}}, "463": {"$update": {"ARO_description": "CTX-M-30 is a beta-lactamase found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"2043": {"$update": {"dna_sequence": {"$update": {"accession": "AY292654.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-30"}}, "1200": {"$insert": {"CARD_short_name": "msrA"}}, "5472": {"$insert": {"CARD_short_name": "PDC-342"}}, "5554": {"$insert": {"CARD_short_name": "PDC-424"}}, "5557": {"$insert": {"CARD_short_name": "PDC-427"}}, "5556": {"$insert": {"CARD_short_name": "PDC-426"}}, "5551": {"$insert": {"CARD_short_name": "PDC-421"}}, "5550": {"$insert": {"CARD_short_name": "PDC-420"}}, "5553": {"$insert": {"CARD_short_name": "PDC-423"}}, "5552": {"$insert": {"CARD_short_name": "PDC-422"}}, "3393": {"$update": {"ARO_description": "A plasmid-mediated MCR-4 variant and colistin resistance gene from clinical Enterobacteriaceae."}, "$insert": {"CARD_short_name": "MCR-4.3"}}, "4905": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-579"}}, "5559": {"$insert": {"CARD_short_name": "PDC-430"}}, "2006": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"837": {"$update": {"dna_sequence": {"$update": {"accession": "JF894248.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-27"}}, "1273": {"$update": {"ARO_description": "otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus.", "model_sequences": {"$update": {"sequence": {"$update": {"660": {"$update": {"dna_sequence": {"$update": {"accession": "X53401.1"}}}}}}}}}, "$insert": {"CARD_short_name": "otr(A)"}}, "4854": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-519"}}, "4861": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7236": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-526"}}, "4224": {"$insert": {"CARD_short_name": "ADC-154"}}, "5521": {"$insert": {"CARD_short_name": "PDC-391"}}, "937": {"$update": {"ARO_description": "OXA-242 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1838": {"$update": {"dna_sequence": {"$update": {"accession": "JX025022.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-242"}}, "5493": {"$insert": {"CARD_short_name": "PDC-363"}}, "4955": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-629"}}, "1519": {"$update": {"ARO_description": "vatE is a transposon-mediated acetyltransferase found in Enterococcus faecium.", "model_sequences": {"$update": {"sequence": {"$update": {"507": {"$update": {"dna_sequence": {"$update": {"accession": "AF242872.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vatE"}}, "1518": {"$update": {"ARO_description": "EreA2 is an integron-encoded erythromycin esterase that hydrolyses the drug's lactone ring. EreA2 is found in Providencia stuartii.", "model_sequences": {"$update": {"sequence": {"$update": {"219": {"$update": {"dna_sequence": {"$update": {"accession": "AF099140.1"}}}}}}}}}, "$insert": {"CARD_short_name": "EreA2"}}, "3392": {"$insert": {"CARD_short_name": "MCR-4.2"}}, "1515": {"$update": {"ARO_description": "NDM-3 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"859": {"$update": {"dna_sequence": {"$update": {"accession": "JQ734687.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-3"}}, "1514": {"$update": {"ARO_description": "IMP-28 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"913": {"$update": {"dna_sequence": {"$update": {"accession": "JQ407409.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-28"}}, "1517": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6224": {"$update": {"dna_sequence": {"$update": {"accession": "AY008291.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-33"}}, "1516": {"$update": {"ARO_description": "CMY-45 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1663": {"$update": {"dna_sequence": {"$update": {"accession": "FN546177.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-45"}}, "1511": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"978": {"$update": {"dna_sequence": {"$update": {"accession": "KM433672.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-423"}}, "1510": {"$update": {"ARO_description": "Also known as vanTrL, is a vanT variant found in the vanL gene cluster. vanTrL codes for the racemase component of vanT.", "model_sequences": {"$update": {"sequence": {"$update": {"353": {"$update": {"dna_sequence": {"$update": {"accession": "EU250284.1"}}}}}}}}, "model_name": "vanTr gene in vanL cluster", "ARO_name": "vanTr gene in vanL cluster"}, "$insert": {"CARD_short_name": "vanTr_in_vanL"}}, "1513": {"$update": {"ARO_description": "QnrB64 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"74": {"$update": {"dna_sequence": {"$update": {"accession": "KC580653.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB64"}}, "1512": {"$update": {"ARO_description": "SME-3 is a beta-lactamase found in Serratia marcescens.", "model_sequences": {"$update": {"sequence": {"$update": {"1487": {"$update": {"dna_sequence": {"$update": {"accession": "AY584237.1"}}}}}}}}}, "$insert": {"CARD_short_name": "SME-3"}}, "1903": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mdtE"}}, "5608": {"$insert": {"CARD_short_name": "PDC-95"}}, "959": {"$update": {"ARO_description": "OXA-64 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1692": {"$update": {"dna_sequence": {"$update": {"accession": "AY750907.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-64"}}, "4225": {"$insert": {"CARD_short_name": "ADC-155"}}, "5129": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-827"}}, "281": {"$update": {"ARO_description": "CMY-110 is a beta-lactamase found in Escherichia coli."}, "$insert": {"CARD_short_name": "CMY-110"}}, "4010": {"$update": {"ARO_description": "PDC-118 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-118"}}, "3439": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-272"}}, "1253": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1481": {"$update": {"dna_sequence": {"$update": {"accession": "KF179354.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-23"}}, "3395": {"$update": {"ARO_description": "A plasmid-mediated MCR-4 variant and colistin resistance gene."}, "$insert": {"CARD_short_name": "MCR-4.5"}}, "1735": {"$update": {"ARO_description": "vatA is a plasmid-mediated acetyltransferase found in Staphylococcus aureus.", "model_sequences": {"$update": {"sequence": {"$update": {"144": {"$update": {"dna_sequence": {"$update": {"accession": "L07778.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vatA"}}, "4859": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-524"}}, "958": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2112": {"$update": {"dna_sequence": {"$update": {"accession": "KJ997966.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-418"}}, "3129": {"$insert": {"CARD_short_name": "MCR-6.1"}}, "3394": {"$update": {"ARO_description": "A plasmid-mediated MCR-4 variant and colistin resistance gene."}, "$insert": {"CARD_short_name": "MCR-4.4"}}, "4858": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-523"}}, "1276": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"884": {"$update": {"dna_sequence": {"$update": {"accession": "JF795487.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-210"}}, "5646": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8021": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "SGM-3"}}, "4227": {"$insert": {"CARD_short_name": "ADC-157"}}, "5344": {"$insert": {"CARD_short_name": "PDC-205"}}, "2135": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "ACT-33"}}, "5579": {"$insert": {"CARD_short_name": "PDC-452"}}, "1896": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1829": {"$update": {"dna_sequence": {"$update": {"accession": "AB926431.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-12"}}, "3397": {"$insert": {"CARD_short_name": "sta"}}, "582": {"$update": {"ARO_description": "FOX-7 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1355": {"$update": {"dna_sequence": {"$update": {"accession": "AJ703795.1"}}}}}}}}, "ARO_category": {"$update": {"36206": {"$update": {"category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins."}}}}}, "$insert": {"CARD_short_name": "FOX-7"}}, "2069": {"$update": {"ARO_description": "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to neomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"3235": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin"}, "$insert": {"CARD_short_name": "Ecol_16rrsB_NEO"}}, "4538": {"$insert": {"CARD_short_name": "CTX-M-209"}}, "985": {"$update": {"ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmA"}}, "4019": {"$update": {"ARO_description": "PDC-285 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-285"}}, "4018": {"$update": {"ARO_description": "PDC-346 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-346"}}, "4661": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7036": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-49"}}, "4013": {"$update": {"ARO_description": "PDC-323 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-323"}}, "4012": {"$update": {"ARO_description": "PDC-324 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-324"}}, "4011": {"$update": {"ARO_description": "PDC-384 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-384"}}, "905": {"$update": {"ARO_description": "CTX-M-93 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"2045": {"$update": {"dna_sequence": {"$update": {"accession": "HQ166709.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-93"}}, "4017": {"$update": {"ARO_description": "PDC-201 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-201"}}, "4016": {"$update": {"ARO_description": "PDC-264 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-264"}}, "4015": {"$update": {"ARO_description": "PDC-413 is a class C beta-lactamase found in Pseudomonas aeruginosa."}, "$insert": {"CARD_short_name": "PDC-413"}}, "3396": {"$insert": {"CARD_short_name": "MCR-5.2"}}, "357": {"$update": {"ARO_description": "VIM-38 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"8265": {"dna_sequence": {"partial": "0", "sequence": "ATGTTAAAAGTTATTAGTAGTTTATTGGTCTATTTGACCGCGTCTGTCATGGCTGTAGCTAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGGCTTTACCAGATTGCTGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCGGTCTACCCATCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCCCTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGAAGGCTGGAGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCCGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAACGTGCTATACGGTGGTTGTGCCGTTCTTGCGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCACAGCACACAAAAATCGCTCAGTCGTTGAGTAG", "fmax": "801", "accession": "KC469971.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AGE83081.2", "sequence": "MLKVISSLLVYLTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRKAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLALSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVTAHKNRSVVE"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-38"}}, "4904": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-578"}}, "355": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1951": {"$update": {"dna_sequence": {"$update": {"accession": "AL513383.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-1"}}, "4856": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-521"}}, "353": {"$update": {"ARO_description": "QnrB2 is a plasmid-mediated quinolone resistance protein found in Citrobacter koseri.", "model_sequences": {"$update": {"sequence": {"$update": {"531": {"$update": {"dna_sequence": {"$update": {"accession": "EF488762.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB2"}}, "352": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1696": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666068.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "PDC-5"}}, "351": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1875": {"$update": {"dna_sequence": {"$update": {"accession": "Y11069.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-6"}}, "350": {"$update": {"ARO_description": "ykkD is an SMR-type protein that is a subunit of the ykkCD efflux pump.", "model_sequences": {"$update": {"sequence": {"$update": {"536": {"$update": {"dna_sequence": {"$update": {"accession": "AL009126.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ykkD"}}, "3985": {"$update": {"ARO_description": "TEM-210.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-210"}}, "3986": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-212"}}, "3987": {"$update": {"ARO_description": "TEM-224 is a beta-lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-224"}}, "3980": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-35"}}, "3981": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-36"}}, "359": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1719": {"$update": {"dna_sequence": {"$update": {"accession": "AY589493.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-112"}}, "358": {"$update": {"ARO_description": "QnrB42 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"35": {"$update": {"dna_sequence": {"$update": {"accession": "JN680743.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB42"}}, "4833": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-324"}}, "42": {"$update": {"ARO_description": "OXY-6-1 is a beta-lactamase found in Klebsiella oxytoca.", "model_sequences": {"$update": {"sequence": {"$update": {"897": {"$update": {"dna_sequence": {"$update": {"accession": "AJ871874.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXY-6-1"}}, "3612": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "HERA-3"}}, "2008": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1943": {"$update": {"dna_sequence": {"$update": {"accession": "JX013655.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-145"}}, "3613": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "HERA-4"}}, "1354": {"$update": {"ARO_description": "Specific mutations that occurs on Mycobacterium tuberculosis embA leading to the lowered affinity of ethambutol to embA.", "model_sequences": {"$update": {"sequence": {"$update": {"2081": {"$update": {"dna_sequence": {"$update": {"accession": "CP003248.1"}}}}}}}}, "ARO_category": {"$update": {"40045": {"$update": {"category_aro_description": "Mutations that occurs on the embA genes resulting in the resistance to ethambutol."}}}}}, "$insert": {"CARD_short_name": "Mtub_embA_EMB"}}, "4421": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. 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All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-35"}}, "1033": {"$update": {"ARO_description": "Also known as vanSN, is a vanS variant found in the vanN gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"78": {"$update": {"dna_sequence": {"$update": {"accession": "JF802084.1"}}}}}}}}, "model_name": "vanS gene in vanN cluster", "ARO_name": "vanS gene in vanN cluster"}, "$insert": {"CARD_short_name": "vanS_in_vanN_cl"}}, "2323": {"$update": {"ARO_description": "qacH is a subunit of the qac multidrug efflux pump in Staphylococcus saprophyticus.", "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}}, "$insert": {"CARD_short_name": "qacH"}}, "1111": {"$update": {"ARO_description": "AAC(6')-Ig is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter haemolyticus.", "model_sequences": {"$update": {"sequence": {"$update": {"396": {"$update": {"dna_sequence": {"$update": {"accession": "L09246.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ig"}}, "2321": {"$update": {"ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "cdeA"}}, "4704": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-79"}}, "4703": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-78"}}, "2326": {"$update": {"ARO_description": "TLA-3 is a beta-lactamase found in a transferable plasmid of Serratia marcescens clinical isolate. It confers resistance to ceftazidime, cefotaxime and cefepime, but not to cefmetazole and meropenem."}, "$insert": {"CARD_short_name": "TLA-3"}}, "4701": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-76"}}, "2324": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "gadW"}}, "5257": {"$insert": {"CARD_short_name": "PDC-121"}}, "2329": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-9"}}, "2328": {"$update": {"model_name": "MUS-2"}, "$insert": {"CARD_short_name": "MUS-2"}}, "1445": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"333": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}}}}}}}, "model_name": "AcrE", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "AcrE"}}, "4709": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-84"}}, "4708": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-83"}}, "289": {"$update": {"ARO_description": "OXA-85 is a beta-lactamase found in Fusobacterium nucleatum.", "model_sequences": {"$update": {"sequence": {"$update": {"814": {"$update": {"dna_sequence": {"$update": {"accession": "AY227054.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-85"}}, "288": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1625": {"$update": {"dna_sequence": {"$update": {"accession": "JF460794.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-60"}}, "1109": {"$update": {"ARO_description": "CAU-1 is a B3 metallo-beta-lactamase that is encoded by the Caulobacter crescentus chromosome.", "model_sequences": {"$update": {"sequence": {"$update": {"760": {"$update": {"dna_sequence": {"$update": {"accession": "AJ308331.1"}}}}}}}}, "model_name": "CAU-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CAU-1"}}, "754": {"$update": {"ARO_description": "CTX-M-48 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"908": {"$update": {"dna_sequence": {"$update": {"accession": "AY847144.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-48"}}, "4426": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-42"}}, "4620": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-37"}}, "1115": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2121": {"$update": {"dna_sequence": {"$update": {"accession": "KP144324.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-435"}}, "283": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1117": {"$update": {"dna_sequence": {"$update": {"accession": "KJ207202.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-85"}}, "282": {"$update": {"ARO_description": "CTX-M-125 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1410": {"$update": {"dna_sequence": {"$update": {"accession": "JQ724542.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-125"}}, "285": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1488": {"$update": {"dna_sequence": {"$update": {"accession": "AY874537.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-11"}}, "284": {"$update": {"ARO_description": "smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia.", "model_sequences": {"$update": {"sequence": {"$update": {"570": {"$update": {"dna_sequence": {"$update": {"accession": "AJ252200.1"}}}}}}}}}, "$insert": {"CARD_short_name": "smeD"}}, "287": {"$update": {"model_sequences": {"$update": {"sequence": {"8159": {"dna_sequence": {"partial": "0", "sequence": "ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCATTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATAAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTTGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "fmax": "1311", "accession": "AF091113.2", "fmin": "450", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Proteus mirabilis", "NCBI_taxonomy_id": "584", "NCBI_taxonomy_cvterm_id": "36771"}, "protein_sequence": {"accession": "AAD33116.2", "sequence": "MSIQHFRVALIPFFAAFCIPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSCGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-67"}}, "3955": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-227"}}, "3760": {"$insert": {"CARD_short_name": "CMY-150"}}, "3761": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LMB-1"}}, "3762": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-68"}}, "3763": {"$insert": {"CARD_short_name": "cfr(D)"}}, "1117": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"240": {"$update": {"dna_sequence": {"$update": {"accession": "L08389.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmD"}}, "3766": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-4"}}, "3767": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-5"}}, "3768": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-6"}}, "3769": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "FRI-7"}}, "1440": {"$update": {"ARO_description": "CTX-M-103 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1026": {"$update": {"dna_sequence": {"$update": {"accession": "HG423149.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-103"}}, "263": {"$update": {"ARO_description": "dfrA24 is an integron-encoded dihydrofolate reductase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"66": {"$update": {"dna_sequence": {"$update": {"accession": "AJ972619.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrA24"}}, "262": {"$update": {"ARO_description": "VIM-8 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1084": {"$update": {"dna_sequence": {"$update": {"accession": "AY524987.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-8"}}, "261": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1994": {"$update": {"dna_sequence": {"$update": {"accession": "JF780936.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-65"}}, "260": {"$update": {"ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmN"}}, "267": {"$update": {"ARO_description": "OXA-43 is a beta-lactamase found in Burkholderia pseudomallei.", "model_sequences": {"$update": {"sequence": {"$update": {"1303": {"$update": {"dna_sequence": {"$update": {"accession": "AJ488303.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-43"}}, "266": {"$update": {"ARO_description": "QnrB13 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"213": {"$update": {"dna_sequence": {"$update": {"accession": "EU273755.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB13"}}, "265": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"900": {"$update": {"dna_sequence": {"$update": {"accession": "GU932590.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-128"}}, "264": {"$update": {"ARO_description": "lsaE is an ABC-F subfamily protein found in porcine MRSA isolates. It confers resistance to pleuromutilin, lincosamide, and streptogramin A."}, "$insert": {"CARD_short_name": "lsaE"}}, "286": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"830": {"$update": {"dna_sequence": {"$update": {"accession": "JX121129.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-162"}}, "269": {"$update": {"ARO_description": "CMY-8 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8198": {"dna_sequence": {"partial": "0", "sequence": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "fmax": "1761", "accession": "AF167990.3", "fmin": "612", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAD50818.2", "sequence": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG"}}}}}}, "$insert": {"CARD_short_name": "CMY-8"}}, "268": {"$update": {"ARO_description": "CfxA6 beta-lactamase is a class A beta-lactamase found in an uncultured bacterium.", "model_sequences": {"$update": {"sequence": {"$update": {"1744": {"$update": {"dna_sequence": {"$update": {"accession": "GQ342996.1"}}}}}}}}, "ARO_category": {"$update": {"39434": {"$update": {"category_aro_description": "CfxA beta-lactamases are class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "CfxA6"}}, "5009": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-697"}}, "1562": {"$update": {"ARO_description": "ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis.", "model_sequences": {"$update": {"sequence": {"$update": {"6244": {"$update": {"dna_sequence": {"$update": {"accession": "AY712687.1"}}}}}}}}, "ARO_category": {"$update": {"36364": {"$update": {"category_aro_description": "Nucelotidylylation of streptomycin at the hydroxyl group at position 6."}}}}}, "$insert": {"CARD_short_name": "aad(6)"}}, "4648": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7023": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-35"}}, "4649": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7024": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-36"}}, "1980": {"$update": {"ARO_description": "OXA-247 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"972": {"$update": {"dna_sequence": {"$update": {"accession": "JX893517.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-247"}}, "4632": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7007": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-19"}}, "4642": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7017": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-29"}}, "4643": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-30"}}, "4640": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-27"}}, "4641": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-28"}}, "4646": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7021": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-33"}}, "4631": {"$insert": {"CARD_short_name": "GMB-1"}}, "4644": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7019": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-31"}}, "4645": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7020": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-32"}}, "5412": {"$insert": {"CARD_short_name": "PDC-278"}}, "4424": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-40"}}, "4630": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7005": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "GIL-1"}}, "1566": {"$update": {"ARO_description": "Also known as vanXD, is a vanX variant found in the vanD gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"652": {"$update": {"dna_sequence": {"$update": {"accession": "AY082011.1"}}}}}}}}, "model_name": "vanX gene in vanD cluster", "ARO_name": "vanX gene in vanD cluster"}, "$insert": {"CARD_short_name": "vanX_in_vanD_cl"}}, "2259": {"$insert": {"CARD_short_name": "mphG"}}, "4712": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-89"}}, "2257": {"$update": {"ARO_description": "Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A."}, "$insert": {"CARD_short_name": "Pros_EFTu_GE2A"}}, "2256": {"$update": {"model_name": "Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid"}, "$insert": {"CARD_short_name": "Saur_fusE_FA"}}, "1295": {"$update": {"ARO_description": "catII is a plasmid-encoded variant of the cat gene found in Haemophilus influenzae, Agrobacterium tumefaciens and Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"742": {"$update": {"dna_sequence": {"$update": {"accession": "X53797.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catII"}}, "5470": {"$insert": {"CARD_short_name": "PDC-340"}}, "2251": {"$update": {"ARO_description": "The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane."}, "$insert": {"CARD_short_name": "LpxC"}}, "2250": {"$insert": {"CARD_short_name": "fusC"}}, "5159": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-862"}}, "2476": {"$update": {"ARO_description": "Point mutations in Halobacterium 16S rRNA that confer resistance to pactamycin antibiotic.", "ARO_category": {"$update": {"40805": {"$update": {"category_aro_description": "Point mutations in bacterial 16S rRNA that confer resistance to antibiotic pactamycin."}}, "40804": {"$update": {"category_aro_description": "Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor."}}}}, "model_name": "Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin"}, "$insert": {"CARD_short_name": "Hsal_16S_PAC"}}, "988": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"413": {"$update": {"dna_sequence": {"$update": {"accession": "AF038993.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(J)"}}, "989": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"590": {"$update": {"dna_sequence": {"$update": {"accession": "L42817.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}, "37022": {"$update": {"category_aro_name": "pristinamycin IC", "category_aro_description": "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1."}}, "36722": {"$update": {"category_aro_description": "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains."}}}}}, "$insert": {"CARD_short_name": "ErmG"}}, "4635": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-22"}}, "982": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1156": {"$update": {"dna_sequence": {"$update": {"accession": "KC149518.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-153"}}, "983": {"$update": {"ARO_description": "GES-20 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1259": {"$update": {"dna_sequence": {"$update": {"accession": "JN596280.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-20"}}, "980": {"$update": {"ARO_description": "Class A beta-lactamase found in Yersinia enterocolitica biovar 1A.", "model_sequences": {"$update": {"sequence": {"$update": {"3318": {"$update": {"dna_sequence": {"$update": {"accession": "AY954728.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Yent_y56"}}, "981": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"895": {"$update": {"dna_sequence": {"$update": {"accession": "DQ149247.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-86"}}, "986": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"608": {"$update": {"dna_sequence": {"$update": {"accession": "AP009048.1"}}}}}}}}}, "$insert": {"CARD_short_name": "baeS"}}, "987": {"$update": {"ARO_description": "CTX-M-4 is a beta-lactamase found in Salmonella typhimurium.", "model_sequences": {"$update": {"sequence": {"$update": {"1512": {"$update": {"dna_sequence": {"$update": {"accession": "Y14156.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-4"}}, "984": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2058": {"$update": {"dna_sequence": {"$update": {"accession": "AF469609.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Bbac_gyrA_FLO"}}, "4425": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-41"}}, "115": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1575": {"$update": {"dna_sequence": {"$update": {"accession": "AF250872.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-87"}}, "114": {"$update": {"ARO_description": "dfrA13 is an integron-encoded dihydrofolate reductase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"8268": {"dna_sequence": {"partial": "0", "sequence": "ATGAACCCGGAATCGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGTCCCGATATCCCCTGGAAAATCCCAGGTGAGCAGAAGATTTTTCGCAGGCTCACCGAGAGCAAAGTGGTCGTTATGGGCCGCAAGACATTTGAGTCCATAGGCAAGCCCTTACCAAACCGCCACACAGTGGTGCTCTCGCGCCAAGCTGGTTATAGCGCTCCTGGTTGTGCAGTTGTTTCAACGCTGTCACACGTATCGCCATCGACAGCCGAACACGGCAAAGAACTCTACGTAGCGCGCGGAGCCGAGGTATATGCGCTGGCGCTACCGCATGCCAACGGCGTCTTTCTATCTGAGGTACATCAAACCTTTGAGGGTGACGCCTTCTTCCCAGTGCTTAACGCAGCAGAATTCGAGGTTGTCTCATCCGAAACCATTCAAGGCACAATCACGTACACGCACTCCGTCTATGCGCGTCGTAACGGCTAA", "fmax": "1215", "accession": "Z50802.3", "fmin": "717", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "CAA90683.1", "sequence": "MNPESVRIYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVVLSRQAGYSAPGCAVVSTLSHVSPSTAEHGKELYVARGAEVYALALPHANGVFLSEVHQTFEGDAFFPVLNAAEFEVVSSETIQGTITYTHSVYARRNG"}}}}}}, "$insert": {"CARD_short_name": "dfrA13"}}, "1790": {"$update": {"ARO_description": "Also known as vanHF, is a vanH variant in the vanF gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"487": {"$update": {"dna_sequence": {"$update": {"accession": "AF155139.1"}}}}}}}}, "model_name": "vanH gene in vanF cluster", "ARO_name": "vanH gene in vanF cluster"}, "$insert": {"CARD_short_name": "vanH_in_vanF_cl"}}, "4090": {"$update": {"ARO_description": "Carbapenem-hydrolyzing class A beta-lactamase kpc-26 [Klebsiella pneumoniae] Accession: WP_068981634.1.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-26"}}, "111": {"$update": {"ARO_description": "Point mutation in Escherichia coli resulting in aminocoumarin resistance.", "model_sequences": {"$update": {"sequence": {"$update": {"2063": {"$update": {"dna_sequence": {"$update": {"accession": "AP009048.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ecol_gyrB_AMU"}}, "110": {"$update": {"ARO_description": "AAC(6')-Iu is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 17.", "model_sequences": {"$update": {"sequence": {"$update": {"27": {"$update": {"dna_sequence": {"$update": {"accession": "AF031329.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Iu"}}, "113": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1576": {"$update": {"dna_sequence": {"$update": {"accession": "EF420108.1"}}}}}}}}, "ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-5"}}, "112": {"$update": {"ARO_description": "fosA5 is a fosfomycin resistance gene isolated from clinical strain of Escherichia coli E265. It is susceptible to amikacin, tetracycline and imipenem, and resistant to sulphonamide, cephalosporins, gentamicin, ciprofloxacin, chloramphenicol and streptomycin.", "model_name": "fosA5", "ARO_name": "fosA5"}, "$insert": {"CARD_short_name": "fosA5"}}, "119": {"$update": {"ARO_description": "VIM-12 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"934": {"$update": {"dna_sequence": {"$update": {"accession": "DQ143913.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "VIM-12"}}, "4639": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "GOB-26"}}, "2785": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Kpne_OmpK37"}}, "4801": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7176": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "ORR-1"}}, "4802": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114b"}}, "2786": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4100": {"$update": {"dna_sequence": {"$update": {"accession": "AY312416.1"}}, "protein_sequence": {"$update": {"accession": "AAP82271.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Bpse_Omp38"}}, "2781": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4096": {"$update": {"dna_sequence": {"$update": {"accession": "KY086517.1"}}, "protein_sequence": {"$update": {"accession": "APB87301.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "porin_OmpC"}}, "2780": {"$update": {"ARO_description": "FosA7 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule."}, "$insert": {"CARD_short_name": "FosA7"}}, "2783": {"$update": {"model_sequences": {"$update": {"sequence": {"8288": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAAAACTCTATTAGCACTCGCAGTGCTTGCAGCCGCAGGCTCTGTAAACGCAGCTGAAATTCTAAAATCAGATGCTGGCACTGTTGATTTTTACGGTCAGCTACGTACAGAATTGAAATTCTTAGAAGATAAAGATCCAACAATTGGTTCTGGTTCTTCGCGCGCTGGTGTTGATGCAAACTACACCGTTAACGATAGCTTAGCGTTACAAGGTAAAGTGGAATTCGCACTAAAAGACAGTGGCGATATGTATGTTCGTAACCACATTCTTGGTGTAAAAACTAATTTTGGTAAGTTTAGCTTTGGTAAACAATGGACTACATCTGACGATGTATACGGTGCTGACTACTCTTATTTCTTTGGTGGTACAGGTCTTCGTTACGGCACACTGTCTGATGCACTACACGATTCTCAAGTCAAGTATGTTTACGAAGCTGACAGCTTCTGGGTTAAAGCTGGTTACGGTTTTCCAGAAGATAATGCAAAGCAAGAGCTAGCAGAACTGTATGTAGGTGCAACATTTGGTGATTTGGCTGTGCACGCTGGTGGTGGTCAAAACCGTGATAAAGCATTCAAAGTTGGTAGTAATACGGTTGGCACAACAACCACAGATATTAAAGCTGACGTAACAAATAGTTACTTTGAAGTGACAGGTGAGTACACTATTGGTGATGCACTGATTGGTGTTACTTACTACAACGCAGAACTAGATGTAGAAAATAACCCACTAGTGATCGATGAAGACGCTATTTCTGTTGCTGGTACATACAAAGTTGCTGACAAGACAAAATTGTATGCTGGCTATGAGTATGTAATGCAAGAAGCGAACACTGGCGCAGATGAAGATGGTACTCTTGTTTACCTAGGTGTTGAATACAAATTTGCAAGCTGGGCTCGTGTATATGCTGAGTATGGCTACGGCGATGGTACAACTCTGGGTTACACCAACAAGGGTTCTGACGCAGAAGTTAAAGCAACGAAAGTCGACAGCGCTAATAACTTTGGTATCGGCGCTCGTATCTACTGGTAA", "fmax": "1821", "accession": "AF079766.2", "fmin": "786", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Vibrio cholerae", "NCBI_taxonomy_id": "666", "NCBI_taxonomy_cvterm_id": "36789"}, "protein_sequence": {"accession": "AAC28105.1", "sequence": "MKKTLLALAVLAAAGSVNAAEILKSDAGTVDFYGQLRTELKFLEDKDPTIGSGSSRAGVDANYTVNDSLALQGKVEFALKDSGDMYVRNHILGVKTNFGKFSFGKQWTTSDDVYGADYSYFFGGTGLRYGTLSDALHDSQVKYVYEADSFWVKAGYGFPEDNAKQELAELYVGATFGDLAVHAGGGQNRDKAFKVGSNTVGTTTTDIKADVTNSYFEVTGEYTIGDALIGVTYYNAELDVENNPLVIDEDAISVAGTYKVADKTKLYAGYEYVMQEANTGADEDGTLVYLGVEYKFASWARVYAEYGYGDGTTLGYTNKGSDAEVKATKVDSANNFGIGARIYW"}}}}}}, "$insert": {"CARD_short_name": "Vcho_OmpT"}}, "2782": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4097": {"$update": {"dna_sequence": {"$update": {"accession": "KJ699300.1"}}, "protein_sequence": {"$update": {"accession": "AID70696.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Vcho_OmpU"}}, "4808": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114h"}}, "4809": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-114i"}}, "964": {"$update": {"ARO_description": "OXA-129 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"1450": {"$update": {"dna_sequence": {"$update": {"accession": "AM932669.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-129"}}, "2789": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5859": {"$update": {"protein_sequence": {"$update": {"accession": "NP_310518.1"}}}}}}}}, "model_name": "Escherichia coli mipA", "ARO_category": {"$update": {"40429": {"$update": {"category_aro_description": "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)."}}}}}, "$insert": {"CARD_short_name": "Ecol_mipA"}}, "4486": {"$insert": {"CARD_short_name": "CSA-2"}}, "1797": {"$update": {"ARO_description": "ErmY is a plasmid-mediated methyltransferase found in Staphylococcus aureus.", "model_sequences": {"$update": {"sequence": {"$update": {"630": {"$update": {"dna_sequence": {"$update": {"accession": "AB014481.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ErmY"}}, "2079": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3696": {"$update": {"dna_sequence": {"$update": {"accession": "NG_050600.1"}}}}}}}}}, "$insert": {"CARD_short_name": "sgm"}}, "2078": {"$insert": {"CARD_short_name": "Mche_16S_KAN"}}, "1331": {"$update": {"ARO_description": "CTX-M-52 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1335": {"$update": {"dna_sequence": {"$update": {"accession": "DQ223685.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-52"}}, "2073": {"$update": {"ARO_description": "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to G418.", "model_sequences": {"$update": {"sequence": {"$update": {"3230": {"$update": {"dna_sequence": {"$update": {"accession": "U00096.1"}}, "NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Escherichia coli str. K-12"}}}}}}}}, "model_name": "Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to G418"}, "$insert": {"CARD_short_name": "Ecol_16S_G418"}}, "2072": {"$update": {"ARO_description": "NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NmcR"}}, "2071": {"$update": {"ARO_description": "AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae."}, "$insert": {"CARD_short_name": "AAC(6')-Ib8"}}, "2070": {"$insert": {"CARD_short_name": "Mtub_16S_AMK"}}, "2077": {"$update": {"ARO_description": "Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to neomycin.", "model_name": "Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin"}, "$insert": {"CARD_short_name": "Msme_16rrsA_NEO"}}, "2076": {"$update": {"ARO_description": "Point mutations in the helix 34 region of 16S rRNA of Neisseria gonorrhoeae can confer resistance against spectinomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"4136": {"$update": {"dna_sequence": {"$update": {"accession": "CP020418.1"}}}}}}}}}, "$insert": {"CARD_short_name": "Ngon_16S_SPT"}}, "2075": {"$update": {"ARO_description": "SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression of many multidrug efflux pumps.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Sent_soxR_MULT"}}, "2074": {"$update": {"ARO_description": "Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin.", "model_sequences": {"$update": {"sequence": {"$update": {"3227": {"$update": {"dna_sequence": {"$update": {"accession": "AE006468.1"}}}}}}}}, "model_name": "Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin"}, "$insert": {"CARD_short_name": "Sent_16S_SPT"}}, "5087": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-778"}}, "4867": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-532"}}, "4483": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6858": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "CRH-3"}}, "952": {"$insert": {"CARD_short_name": "sul2"}}, "1796": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1344": {"$update": {"dna_sequence": {"$update": {"accession": "KM087845.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-119"}}, "1330": {"$insert": {"CARD_short_name": "emrR"}}, "3305": {"$update": {"ARO_description": "EreD is an erythromycin esterase protein."}, "$insert": {"CARD_short_name": "EreD"}}, "1389": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1112": {"$update": {"dna_sequence": {"$update": {"accession": "KM379100.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-22"}}, "3508": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-438"}}, "3509": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-439"}}, "5089": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-781"}}, "1026": {"$update": {"model_sequences": {"$update": {"sequence": {"8225": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGACGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "891", "accession": "AM176549.2", "fmin": "30", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47129.2", "sequence": "MRYIRLCIISLLATLPLTVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-74"}}, "3500": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-417"}}, "3501": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-427"}}, "3502": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-429"}}, "3503": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-430"}}, "3504": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-431"}}, "3505": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-432"}}, "3506": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-433"}}, "3507": {"$update": {"ARO_description": "Assigned by Lahey's list of beta-lactamases, no accessions or other information available.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-437"}}, "641": {"$update": {"ARO_description": "CARB-6 is a beta-lactamase found in Vibrio cholerae.", "model_sequences": {"$update": {"sequence": {"$update": {"1736": {"$update": {"dna_sequence": {"$update": {"accession": "AF030945.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-6"}}, "2060": {"$update": {"ARO_description": "FosC2 is an enzyme that phosphorylates fosfomycin to confer resistance in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"580": {"$update": {"dna_sequence": {"$update": {"accession": "AB522969.1"}}}}}}}}}, "$insert": {"CARD_short_name": "FosC2"}}, "1446": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1771": {"$update": {"dna_sequence": {"$update": {"accession": "FJ666069.1"}}}}}}}}}, "$insert": {"CARD_short_name": "PDC-6"}}, "2679": {"$update": {"model_description": "A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems).", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "MexAB-OprM with MexR mutations confers resistance to multiple antibiotics"}, "$insert": {"CARD_short_name": "Paer_MexR_MULT"}}, "1209": {"$update": {"ARO_description": "QnrB45 is a plasmid-mediated quinolone resistance protein found in Escherichia coli.", "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB45"}}, "3220": {"$insert": {"CARD_short_name": "mphJ"}}, "1532": {"$update": {"ARO_description": "OXA-249 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1130": {"$update": {"dna_sequence": {"$update": {"accession": "HE963770.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-249"}}, "1332": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"233": {"$update": {"dna_sequence": {"$update": {"accession": "CP004067.1"}}}}}}}}, "ARO_category": {"$update": {"36265": {"$update": {"category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'."}}}}}, "$insert": {"CARD_short_name": "APH(3')-IIIa"}}, "5331": {"$insert": {"CARD_short_name": "PDC-192"}}, "5330": {"$insert": {"CARD_short_name": "PDC-191"}}, "5333": {"$insert": {"CARD_short_name": "PDC-194"}}, "5332": {"$insert": {"CARD_short_name": "PDC-193"}}, "5335": {"$insert": {"CARD_short_name": "PDC-196"}}, "5334": {"$insert": {"CARD_short_name": "PDC-195"}}, "5337": {"$insert": {"CARD_short_name": "PDC-198"}}, "5336": {"$insert": {"CARD_short_name": "PDC-197"}}, "5339": {"$insert": {"CARD_short_name": "PDC-20"}}, "708": {"$update": {"ARO_description": "CTX-M-49 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1010": {"$update": {"dna_sequence": {"$update": {"accession": "AY847145.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-49"}}, "336": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"546": {"$update": {"dna_sequence": {"$update": {"accession": "AF055922.1"}}}}}}}}, "ARO_category": {"$update": {"37697": {"$update": {"category_aro_description": "Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides."}}}}}, "$insert": {"CARD_short_name": "Sfra_tlrB_TYL"}}, "1630": {"$update": {"ARO_description": "IMP-13 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1906": {"$update": {"dna_sequence": {"$update": {"accession": "AJ550807.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-13"}}, "1631": {"$update": {"ARO_description": "CTX-M-71 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1513": {"$update": {"dna_sequence": {"$update": {"accession": "FJ815436.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-71"}}, "1632": {"$update": {"ARO_description": "CTX-M-53 is a beta-lactamase found in Salmonella enterica.", "model_sequences": {"$update": {"sequence": {"8257": {"dna_sequence": {"partial": "0", "sequence": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGTGGACGTACAGCAAAAACTTGCCGAATTAGAGCAGCAGTCGGGAGGAAGGCTGGGTGTGGCATTGATTAACACGGCGGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGTGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTCGAGATCAAAAAATCTGACCTGGTTAACTATAATCCGATTGCGGAAAAACACGTCAATGGGACGATGTCACTGGCTGAGCTCAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTTACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCTGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACGCTGCGTAATCTGACGCTGGGTAAAGCATTGGGTGACAGCCAACGGGCGCAGCTGGTGACGTGGATGAAAGGCAATACTACCGGTGCAGCGAGTATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGTACCACCAACGATATCGCGGTGATTTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCATTTACTTCACCCAGCCCCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAG", "fmax": "6767", "accession": "DQ268764.2", "fmin": "5891", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Westhampton", "NCBI_taxonomy_id": "356621", "NCBI_taxonomy_cvterm_id": "35809"}, "protein_sequence": {"accession": "ABB72225.1", "sequence": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELEQQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVIYFTQPQPKAESRRDVLASAAKIVTDGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-53"}}, "1633": {"$update": {"ARO_description": "catQ is a chromosome-encoded variant of the cat gene found in Clostridium perfringens.", "model_sequences": {"$update": {"sequence": {"$update": {"607": {"$update": {"dna_sequence": {"$update": {"accession": "M55620.1"}}}}}}}}, "ARO_category": {"$update": {"36261": {"$update": {"category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini."}}}}}, "$insert": {"CARD_short_name": "catQ"}}, "1634": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1817": {"$update": {"dna_sequence": {"$update": {"accession": "JQ733575.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-78"}}, "1635": {"$update": {"ARO_description": "Also known as vanRG, is a vanR variant found in the vanG gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"246": {"$update": {"dna_sequence": {"$update": {"accession": "DQ212986.1"}}}}}}}}, "model_name": "vanR gene in vanG cluster", "ARO_name": "vanR gene in vanG cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanG_cl"}}, "1636": {"$update": {"ARO_description": "QnrB57 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"485": {"$update": {"dna_sequence": {"$update": {"accession": "JX259318.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB57"}}, "1637": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1446": {"$update": {"dna_sequence": {"$update": {"accession": "GQ152602.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "MOX-7"}}, "1638": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1992": {"$update": {"dna_sequence": {"$update": {"accession": "KJ155695.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-111"}}, "5371": {"$insert": {"CARD_short_name": "PDC-233"}}, "2904": {"$insert": {"CARD_short_name": "poxtA"}}, "3218": {"$update": {"ARO_description": "A macrolide phosphotransferase identified on a plasmid in Exiguobacterium."}, "$insert": {"CARD_short_name": "mphN"}}, "3219": {"$update": {"ARO_description": "A chromosomal macrolide phosphostransferase identified in Brachybacterium paraconglomeratum."}, "$insert": {"CARD_short_name": "mphO"}}, "1988": {"$update": {"ARO_description": "CMY-7 is a beta-lactamase found in Salmonella typhimurium.", "model_sequences": {"$update": {"sequence": {"$update": {"1100": {"$update": {"dna_sequence": {"$update": {"accession": "AJ011291.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-7"}}, "1989": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2069": {"$update": {"dna_sequence": {"$update": {"accession": "CP000647.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "37250": {"$update": {"category_aro_class_name": "Antibiotic"}}}, "$insert": {"43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}}, "$insert": {"CARD_short_name": "Kpne_acrR_MULT"}}, "704": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"385": {"$update": {"dna_sequence": {"$update": {"accession": "U57969.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OprJ"}}, "587": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3324": {"$update": {"dna_sequence": {"$update": {"accession": "AJ012256.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-73"}}, "4738": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-79"}}, "2909": {"$update": {"ARO_description": "Beta-lactamase found in Acinetobacter spp. efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-664"}}, "5345": {"$insert": {"CARD_short_name": "PDC-206"}}, "_timestamp": "2022-04-04T17:58:40+00:00", "568": {"$update": {"ARO_description": "CTX-M-20 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"1168": {"$update": {"dna_sequence": {"$update": {"accession": "AJ416344.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-20"}}, "569": {"$update": {"ARO_description": "OXA-228 is a beta-lactamase found in A. bereziniae.", "model_sequences": {"$update": {"sequence": {"$update": {"2005": {"$update": {"dna_sequence": {"$update": {"accession": "JQ422053.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-228"}}, "2817": {"$update": {"ARO_description": "Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolide type antibiotics."}, "$insert": {"CARD_short_name": "Spne_23S_MAC"}}, "2816": {"$insert": {"CARD_short_name": "Msme_23S_CLR"}}, "2402": {"$insert": {"CARD_short_name": "Hpin_parC_FLO"}}, "2810": {"$update": {"model_name": "Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin"}, "$insert": {"CARD_short_name": "Mabs_23S_CLR"}}, "2813": {"$insert": {"CARD_short_name": "Mint_23S_CLR"}}, "2812": {"$insert": {"CARD_short_name": "Mche_23S_CLR"}}, "560": {"$update": {"ARO_description": "OXA-77 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1538": {"$update": {"dna_sequence": {"$update": {"accession": "AY949202.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-77"}}, "561": {"$update": {"ARO_description": "OKP-B-8 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1920": {"$update": {"dna_sequence": {"$update": {"accession": "AM051157.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-8"}}, "562": {"$update": {"ARO_description": "TEM-187 is an extended-spectrum beta-lactamase found in P. mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1956": {"$update": {"dna_sequence": {"$update": {"accession": "HM246246.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-187"}}, "563": {"$update": {"ARO_description": "OKP-B-6 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8278": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAAGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGTTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGGGATACCGCAGCGACCATGGCCGAACGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAA", "fmax": "878", "accession": "AM850917.2", "fmin": "17", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAP12355.2", "sequence": "MRYVRLCLISLIAALPLAVFASPQPLEQIKISESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTAATMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-6"}}, "564": {"$update": {"model_sequences": {"$update": {"sequence": {"8251": {"dna_sequence": {"partial": "0", "sequence": "ATGAAGAAATTATTTGTTTTATGTGTGTTTTTGTTTTGTAGCATTACTGCCGCAGGAGAGTCTTTGCCCGATTTAAAAATTGAAAAGCTTGAAGAAGGTGTTTATGTTCATACATCGTTTGAAGAAGTTAATGGTTGGGGCGTTGTTTCTAAACACGGTTTGGTTATTCTTGTGAATACTGACGCCTATCTGATTGACACTCCATTCACGGCTAAAGATACTGAAAAGTTAGTCACCTGGTTTGTGGAGCGCGGCTATAAAATCAAAGGTAGCATTTCCTCACATTTCCATAGCGACAGCACGGGTGGAATAGAGTGGCTTAATTCTCAATCAATTCCCACGTATGCATCTGAATTAACAAATGACCTTCTTAAACAAAACGGTAAGGTACAAGCTAAAAACTCATTTAGCGGAGTTAGTTATTGGTTAGTTAAAAATAAAATTGAAGTTTTCTATCCCGGCCCCGGGCACACTCAAGATAACGTAGTGGTTTGGTTGCCTGAAAAGAAAATTTTATTTGGTGGGTGCTTTGTTAAACCGTACGGTCTTGGAAATCTCGATGACGCAAATGTTGTAGCATGGCCACATTCTGCTGAAATATTAATGTCTAGGTATGGTAATGCAAAACTGGTTGTTCCAAGCCATAGTGACATCGGAGATGCGTCGCTCTTGAAGCTTACATGGGAGCAGGCTGTTAAAGGGCTAAAAGAAAGTAAAAAACCATCAGAGCCAAGTAACTAA", "fmax": "1097", "accession": "DQ361087.2", "fmin": "356", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas fluorescens", "NCBI_taxonomy_id": "294", "NCBI_taxonomy_cvterm_id": "36937"}, "protein_sequence": {"accession": "ABC88434.1", "sequence": "MKKLFVLCVFLFCSITAAGESLPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVILVNTDAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNDLLKQNGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPYGLGNLDDANVVAWPHSAEILMSRYGNAKLVVPSHSDIGDASLLKLTWEQAVKGLKESKKPSEPSN"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-22"}}, "565": {"$update": {"model_sequences": {"$update": {"sequence": {"8206": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATGTTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACACCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "861", "accession": "AM176557.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47137.2", "sequence": "MRYVRLCIISLLATLPLAVHTSPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-82"}}, "566": {"$update": {"ARO_description": "OXA-32 is a beta-lactamase found in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1761": {"$update": {"dna_sequence": {"$update": {"accession": "AF315351.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-32"}}, "567": {"$update": {"ARO_description": "CTX-M-41 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1667": {"$update": {"dna_sequence": {"$update": {"accession": "DQ023162.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-41"}}, "4975": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-655"}}, "702": {"$update": {"ARO_description": "CTX-M-98 is a beta-lactamase found in Escherichia coli.", "model_sequences": {"$update": {"sequence": {"$update": {"1030": {"$update": {"dna_sequence": {"$update": {"accession": "HM755448.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-98"}}, "5131": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-829"}}, "5086": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-777"}}, "118": {"$update": {"ARO_description": "LRA-9 is a beta-lactamase isolated from soil samples in Alaska.", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "LRA-9"}}, "659": {"$update": {"ARO_description": "AAC(6')-29b is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa."}, "$insert": {"CARD_short_name": "AAC(6')-29b"}}, "2179": {"$update": {"ARO_description": "Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanE gene cluster is inducible and confers low resistance to vancomycin. vanE organisms remain susceptible to teicoplanin. Gene orientation: E(XY)TRS."}, "$insert": {"CARD_short_name": "vanE_cluster"}}, "1188": {"$update": {"ARO_description": "ErmV is a plasmid-mediated methyltransferase found in Streptomyces viridochromogenes.", "model_sequences": {"$update": {"sequence": {"$update": {"420": {"$update": {"dna_sequence": {"$update": {"accession": "U59450.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ErmV"}}, "1189": {"$update": {"ARO_description": "vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus.", "model_sequences": {"$update": {"sequence": {"$update": {"3345": {"$update": {"dna_sequence": {"$update": {"accession": "U19459.1"}}}}}}}}, "ARO_category": {"$update": {"37013": {"$update": {"category_aro_name": "virginiamycin M1", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}}}}}, "$insert": {"CARD_short_name": "vatB"}}, "1186": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1052": {"$update": {"dna_sequence": {"$update": {"accession": "KF203101.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-327"}}, "1187": {"$update": {"ARO_description": "OXA-248 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1050": {"$update": {"dna_sequence": {"$update": {"accession": "HE963769.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-248"}}, "1184": {"$update": {"model_sequences": {"$update": {"sequence": {"8277": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAAATTTATACTTCCTATCTTCAGCATTTCTATTCTACTTTCTCTCAGTGCATGCTCATCTATTCAAACTAAATTTGAAGATACTTTTCATATTTCTAATCAGAAACATGAAAAAGCTATTAAAAGCTATTTTGATGAAGCTCAAACACAAGGTGTAATTATTATTAAGGAAGGTAAAAATATTAGCTCCTATGGTAATAACCTTGTACGAGCACATACAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCTTTAATCGGACTAGAAAATCATAAAGCGACAACAAATGAGATTTTTAAATGGGATGGTAAAAAAAGATCTTATCCTATGTGGGAGAAAGATATGACTTTGGGTGAGGCCATGGCACTTTCAGCTGTTCCTGTATATCAAGATCTTGCGAGACGGATTGGCTTAAATCTCATGCAAAAAGAAGTTAAACGCGTTGGTTTTGGTAATATGAACATTGGAACACAAGTTGATAATTTCTGGTTGATTGGTCCTCTTAAGATTACACCAATACAAGAAGTGAATTTTGCCGATGATCTTGCGAATAATCGATTACCCTTTAAATTAGAAACTCAAGAAGAAGTAAAAAAGATGCTTCTGATTAAAGAAGTCAATGGTAGTAAAATTTATGCTAAAAGCGGATGGGGAATGGATGTAAGCCCACAAGTAGGTTGGTTAACAGGTTGGGTAGAAAAATCTAATGGAGAAAAAGTTTCCTTTTCTTTAAATATAGAAATGAAGCAAGGAATGTCTGGTTCTATTCGTAATGAGATTACTTATAAGTCGTTAGAAAATTTAGGGATCATCTAA", "fmax": "828", "accession": "HM640278.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "ADK92148.1", "sequence": "MKKFILPIFSISILLSLSACSSIQTKFEDTFHISNQKHEKAIKSYFDEAQTQGVIIIKEGKNISSYGNNLVRAHTEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRSYPMWEKDMTLGEAMALSAVPVYQDLARRIGLNLMQKEVKRVGFGNMNIGTQVDNFWLIGPLKITPIQEVNFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVSPQVGWLTGWVEKSNGEKVSFSLNIEMKQGMSGSIRNEITYKSLENLGII"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-182"}}, "1185": {"$update": {"ARO_description": "OXA-176 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"882": {"$update": {"dna_sequence": {"$update": {"accession": "HM113562.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-176"}}, "3373": {"$insert": {"CARD_short_name": "FosD"}}, "1183": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"476": {"$update": {"dna_sequence": {"$update": {"accession": "Z21523.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tetQ"}}, "1180": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "mdsC"}}, "1181": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"431": {"$update": {"dna_sequence": {"$update": {"accession": "CP000768.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cmeA"}}, "726": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "41361": {"$update": {"category_aro_name": "BlaZ beta-lactamase", "category_aro_description": "BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus."}}}}}, "$insert": {"CARD_short_name": "PC1_blaZ"}}, "5634": {"$insert": {"CARD_short_name": "PST-2"}}, "724": {"$update": {"ARO_description": "AAC(6')-Ij is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 13.", "model_sequences": {"$update": {"sequence": {"$update": {"494": {"$update": {"dna_sequence": {"$update": {"accession": "L29045.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ij"}}, "725": {"$update": {"ARO_description": "GES-11 is a beta-lactamase found in Acinetobacter baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1745": {"$update": {"dna_sequence": {"$update": {"accession": "FJ854362.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "36205": {"$update": {"category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "GES-11"}}, "722": {"$update": {"ARO_description": "Also known as vanRA, is a vanR variant found in the vanA gene cluster.", "model_sequences": {"$update": {"sequence": {"$update": {"3275": {"$update": {"dna_sequence": {"$update": {"accession": "M97297.1"}}}}}}}}, "model_name": "vanR gene in vanA cluster", "ARO_name": "vanR gene in vanA cluster"}, "$insert": {"CARD_short_name": "vanR_in_vanA_cl"}}, "723": {"$update": {"model_sequences": {"$update": {"sequence": {"8162": {"dna_sequence": {"partial": "0", "sequence": "ATGCGTTATTTTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGTAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAGGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "891", "accession": "AM176547.2", "fmin": "30", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "CAJ47127.2", "sequence": "MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-72"}}, "720": {"$update": {"ARO_description": "Bacillus cereus beta-lactamase I is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9.", "model_sequences": {"$update": {"sequence": {"$update": {"1622": {"$update": {"dna_sequence": {"$update": {"accession": "X06599.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BcI"}}, "721": {"$update": {"ARO_description": "OXA-28 is a beta-lactamase found in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"887": {"$update": {"dna_sequence": {"$update": {"accession": "AF231133.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-28"}}, "1744": {"$update": {"ARO_description": "cmrA is a transposon-encoded chloramphenicol exporter that is found in Rhodococcus rhodochrous.", "model_sequences": {"$update": {"sequence": {"$update": {"699": {"$update": {"dna_sequence": {"$update": {"accession": "AF015087.1"}}}}}}}}}, "$insert": {"CARD_short_name": "cmrA"}}, "1745": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1032": {"$update": {"dna_sequence": {"$update": {"accession": "AY034847.1"}}}}}}}}, "model_name": "KPC-2", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "KPC-2"}}, "1746": {"$update": {"ARO_description": "IMP-24 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1907": {"$update": {"dna_sequence": {"$update": {"accession": "EF192154.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-24"}}, "1747": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1441": {"$update": {"dna_sequence": {"$update": {"accession": "KF526116.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-103"}}, "1740": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1886": {"$update": {"dna_sequence": {"$update": {"accession": "AF104441.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-53"}}, "1741": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1763": {"$update": {"dna_sequence": {"$update": {"accession": "KF421162.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-359"}}, "728": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1158": {"$update": {"dna_sequence": {"$update": {"accession": "JF949915.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-192"}}, "729": {"$update": {"ARO_description": "CTX-M-8 is a beta-lactamase found in the Enterobacteriaceae family.", "model_sequences": {"$update": {"sequence": {"$update": {"826": {"$update": {"dna_sequence": {"$update": {"accession": "AF189721.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-8"}}, "1164": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"875": {"$update": {"dna_sequence": {"$update": {"accession": "KM087860.1"}}}}}}}}, "ARO_category": {"$update": {"36197": {"$update": {"category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams."}}}}}, "$insert": {"CARD_short_name": "MIR-9"}}, "1165": {"$update": {"ARO_description": "OKP-A-4 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"1520": {"$update": {"dna_sequence": {"$update": {"accession": "AM051142.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-A-4"}}, "1166": {"$insert": {"CARD_short_name": "Saur_gyrA_FLO"}}, "1167": {"$insert": {"CARD_short_name": "norB"}}, "1160": {"$update": {"ARO_description": "QnrB34 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii.", "model_sequences": {"$update": {"sequence": {"$update": {"512": {"$update": {"dna_sequence": {"$update": {"accession": "JN173056.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB34"}}, "1161": {"$update": {"ARO_description": "LsaB is an ABC-F subfamily protein expressed in Mammaliicoccus sciuri. It confers resistance to clindamycin.", "model_sequences": {"$update": {"sequence": {"$update": {"5173": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Mammaliicoccus sciuri"}}}}}}}}}, "$insert": {"CARD_short_name": "lsaB"}}, "1162": {"$update": {"ARO_description": "aadA15 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"116": {"$update": {"dna_sequence": {"$update": {"accession": "DQ393783.1"}}}}}}}}, "ARO_category": {"$update": {"41439": {"$update": {"category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''."}}}}}, "$insert": {"CARD_short_name": "aadA15"}}, "1163": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1626": {"$update": {"dna_sequence": {"$update": {"accession": "JX514368.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-94"}}, "4246": {"$insert": {"CARD_short_name": "ADC-178"}}, "4247": {"$insert": {"CARD_short_name": "ADC-179"}}, "4244": {"$insert": {"CARD_short_name": "ADC-176"}}, "4245": {"$insert": {"CARD_short_name": "ADC-177"}}, "1168": {"$update": {"model_sequences": {"$update": {"sequence": {"8233": {"dna_sequence": {"partial": "0", "sequence": "ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAAAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA", "fmax": "1192", "accession": "KC999080.2", "fmin": "379", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae subsp. pneumoniae", "NCBI_taxonomy_id": "72407", "NCBI_taxonomy_cvterm_id": "39097"}, "protein_sequence": {"accession": "AGU91756.1", "sequence": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQKGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "NDM-9"}}, "1169": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1932": {"$update": {"dna_sequence": {"$update": {"accession": "KF421163.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-360"}}, "4240": {"$insert": {"CARD_short_name": "ADC-172"}}, "4241": {"$insert": {"CARD_short_name": "ADC-173"}}, "5520": {"$insert": {"CARD_short_name": "PDC-390"}}, "3306": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Ecol_ampC1_BLA"}}, "5522": {"$insert": {"CARD_short_name": "PDC-392"}}, "5523": {"$insert": {"CARD_short_name": "PDC-394"}}, "5524": {"$insert": {"CARD_short_name": "PDC-395"}}, "5525": {"$insert": {"CARD_short_name": "PDC-396"}}, "5526": {"$insert": {"CARD_short_name": "PDC-397"}}, "3307": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}, "model_name": "Escherichia coli ampH beta-lactamase"}, "$insert": {"CARD_short_name": "Ecol_ampH_BLA"}}, "5528": {"$insert": {"CARD_short_name": "PDC-399"}}, "5529": {"$insert": {"CARD_short_name": "PDC-40"}}, "5633": {"$insert": {"CARD_short_name": "PST-1"}}, "1489": {"$update": {"ARO_description": "CMY-37 is a beta-lactamase found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"944": {"$update": {"dna_sequence": {"$update": {"accession": "AB280919.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-37"}}, "749": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"922": {"$update": {"dna_sequence": {"$update": {"accession": "EF373973.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "SHV-97"}}, "4962": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-636"}}, "1488": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5896": {"$update": {"dna_sequence": {"$update": {"accession": "AY130284.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-75"}}, "48": {"$update": {"ARO_description": "OXA-90 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1306": {"$update": {"dna_sequence": {"$update": {"accession": "AM231719.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-90"}}, "49": {"$update": {"ARO_description": "tsnR is a 23S ribosomal RNA methyltransferase that methylates adenosine-1067 to confer resistance to thiostrepton.", "ARO_category": {"$update": {"39499": {"$update": {"category_aro_description": "Non-erm 23S ribosomal RNA methyltransferases modify adenosine 1067 to confer resistance to peptide antibiotics."}}}}}, "$insert": {"CARD_short_name": "tsnR"}}, "46": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"943": {"$update": {"dna_sequence": {"$update": {"accession": "KM087846.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-114"}}, "47": {"$update": {"ARO_description": "OXA-60 is a beta-lactamase found in Ralstonia pickettii.", "model_sequences": {"$update": {"sequence": {"8146": {"dna_sequence": {"partial": "0", "sequence": "ATGCTGTCTCGCTACTCGAAGACCCTCGCGTTTGCCGTGGTGGCCTGCACGCTCGCAATAAGCACCGCCACCGCTCATGCCGAGCTGGTCGTGCGCAATGACCTCAAGCGCGTGTTCGACGACGCCGGCGTCTCCGGCACCTTCGTGCTGATGGACATCACCGCCGACCGTACCTATGTCGTCGATCCGGCGCGTGCCGCGCGGAGCATCCATCCGGCTTCGACGTTCAAGATTCCGAACAGCCTGATCGCCTTCGACACCGGGGCCGTGCGCGACGATCAGGAAGTGCTGCCCTACGGCGGCAAGCCGCAGCCTTACGAGCAGTGGGAGCACGACATGGCGTTACCCGAGGCGATTCGCCTGTCGGCCGTGCCGATCTATCAGGAAGTCGCGCGCCGCGTTGGCTTCGAGCGCATGCAGGCTTATGTCGATGCGTTCGACTACGGCAATCGCCAGCTCGGCAGCGCGATCGACCAGTTCTGGCTGCGTGGCCCGCTGGAGATTTCCGCTTTCGAAGAAGCACGCTTCACCAGCCGCATGGCGCTCAAGCAGTTGCCGGTGAAGCCGCGCACGTGGGACATGGTCCAGCGCATGCTGTTGATCGAGCAGCAGGGCGATGCCGCGCTATATGCCAAGACCGGCGTCGCCACCGAATACCAGCCGGAGATCGGTTGGTGGGCCGGCTGGGTGGAGCGTGCGGGGCATGTCTATGCATTCGCGCTGAACATCGACATGCCGCGCGAGGGCGATATGGCCAAGCGCATTCCGCTGGGCAAGCAGTTGATGCGGGCGCTCGAGGTGTGGCCGGCACCGTGA", "fmax": "3586", "accession": "AF525303.2", "fmin": "2770", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Ralstonia pickettii", "NCBI_taxonomy_id": "329", "NCBI_taxonomy_cvterm_id": "36921"}, "protein_sequence": {"accession": "AAQ08905.1", "sequence": "MLSRYSKTLAFAVVACTLAISTATAHAELVVRNDLKRVFDDAGVSGTFVLMDITADRTYVVDPARAARSIHPASTFKIPNSLIAFDTGAVRDDQEVLPYGGKPQPYEQWEHDMALPEAIRLSAVPIYQEVARRVGFERMQAYVDAFDYGNRQLGSAIDQFWLRGPLEISAFEEARFTSRMALKQLPVKPRTWDMVQRMLLIEQQGDAALYAKTGVATEYQPEIGWWAGWVERAGHVYAFALNIDMPREGDMAKRIPLGKQLMRALEVWPAP"}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-60"}}, "44": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "golS"}}, "45": {"$update": {"ARO_description": "Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.", "ARO_category": {"$update": {"43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "mdtP"}}, "5156": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-859"}}, "43": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"734": {"$update": {"dna_sequence": {"$update": {"accession": "EU523697.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(42)"}}, "40": {"$update": {"ARO_description": "QnrB58 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"532": {"$update": {"dna_sequence": {"$update": {"accession": "JX259319.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB58"}}, "41": {"$update": {"ARO_description": "rmtH is a 16s ribosomal RNA methyltransferase found in Klebsiella pneumoniae strain MRSN2404 that was isolated from the chronic wound of a soldier wounded in Iraq in 2006. It confers high resistance to all aminoglycosides.", "model_sequences": {"$update": {"sequence": {"$update": {"3309": {"$update": {"dna_sequence": {"$update": {"accession": "KC544262.1"}}}}}}}}}, "$insert": {"CARD_short_name": "rmtH"}}, "1568": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1526": {"$update": {"dna_sequence": {"$update": {"accession": "HQ111474.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-183"}}, "1298": {"$insert": {"CARD_short_name": "lsaA"}}, "1299": {"$update": {"ARO_description": "AAC(6')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in S. marcescens.", "model_sequences": {"$update": {"sequence": {"$update": {"306": {"$update": {"dna_sequence": {"$update": {"accession": "M94066.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-Ic"}}, "331": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"846": {"$update": {"dna_sequence": {"$update": {"accession": "FJ197316.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-166"}}, "670": {"$update": {"ARO_description": "IND-3 is a beta-lactamase found in Chryseobacterium indologenes.", "model_sequences": {"$update": {"sequence": {"8190": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAAAAGAATTCAGTTCTTTATGGTTTCAATGATGCTAAGTTCATTATTCAGTGCCCAGGTAAAAGATTTTGTCATCGAACCACCGATTAAAAAGAATTTACATATTTACAAAACTTTTGGTGTATTCGGAGGTAAAGAATATTCTGCCAATTCAGTATATCTTGTTACCCAAAAAGGAGTTGTCTTATTTGACGTCCCGTGGGAAAAGGTACAGTACCAAAGCCTGATGGATACCATCCAAAAACGCCACAATTTACCCGTAATAGCTGTGTTTGCCACTCACTCCCATGATGACCGTGCCGGAGATCTGAGCTTTTTTAACAACAAAGGAATTAAAACCTACGCTACTTCCAAAACCAATGAATTCCTGAAAAAAGACGGAAAAGCAACATCCACAGAGATCATTAAGACCGGAAAGCCATATCGCATAGGAGGTGAGGAATTTGTGGTTGATTTTCTTGGAGAAGGGCATACTGCTGATAATGTAGTGGTATGGTTTCCCAAATACAACGTCCTGGATGGCGGATGCCTTGTAAAAAGTAAAGCTGCAACCGATCTTGGATATATTAAGGAAGCCAATGTAGAGCAATGGCCCAAGACCATCAATAAACTGAAATCCAAATATTCAAAAGCAAGCCTGGTTATTCCCGGACATGATGAATGGAAAGGTGGAGGCCATGTAAAACATACTCTTGAACTTCTTAACAAAAAATAA", "fmax": "720", "accession": "AF219131.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Chryseobacterium indologenes", "NCBI_taxonomy_id": "253", "NCBI_taxonomy_cvterm_id": "36916"}, "protein_sequence": {"accession": "AAG29761.2", "sequence": "MKKRIQFFMVSMMLSSLFSAQVKDFVIEPPIKKNLHIYKTFGVFGGKEYSANSVYLVTQKGVVLFDVPWEKVQYQSLMDTIQKRHNLPVIAVFATHSHDDRAGDLSFFNNKGIKTYATSKTNEFLKKDGKATSTEIIKTGKPYRIGGEEFVVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSKAATDLGYIKEANVEQWPKTINKLKSKYSKASLVIPGHDEWKGGGHVKHTLELLNKK"}}}}}, "ARO_category": {"$update": {"36199": {"$update": {"category_aro_description": "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases."}}}}}, "$insert": {"CARD_short_name": "IND-3"}}, "1292": {"$insert": {"CARD_short_name": "CTX-M-109"}}, "1293": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"883": {"$update": {"dna_sequence": {"$update": {"accession": "HQ425495.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-197"}}, "1290": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1399": {"$update": {"dna_sequence": {"$update": {"accession": "AY956335.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-141"}}, "1291": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1401": {"$update": {"dna_sequence": {"$update": {"accession": "FN652295.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-177"}}, "1296": {"$update": {"ARO_description": "OKP-B-12 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"$update": {"6221": {"$update": {"dna_sequence": {"$update": {"accession": "AJ635420.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}, "38817": {"$update": {"category_aro_description": "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%."}}}}}, "$insert": {"CARD_short_name": "OKP-B-12"}}, "1297": {"$update": {"ARO_description": "CTX-M-80 is a beta-lactamase found in Klebsiella pneumoniae.", "model_sequences": {"$update": {"sequence": {"8241": {"dna_sequence": {"partial": "0", "sequence": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACCGTGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGACTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA", "fmax": "876", "accession": "EU202673.2", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "ABW86620.2", "sequence": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL"}}}}}}, "$insert": {"CARD_short_name": "CTX-M-80"}}, "1294": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3310": {"$update": {"dna_sequence": {"$update": {"accession": "AF321608.1"}}}}}}}}, "model_name": "Sed-1", "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "Sed-1"}}, "1567": {"$insert": {"CARD_short_name": "FosB"}}, "797": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2037": {"$update": {"dna_sequence": {"$update": {"accession": "DQ286729.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "TEM-55"}}, "5022": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-710"}}, "1360": {"$update": {"ARO_description": "Point mutation in Bartonella bacilliformis resulting in aminocoumarin resistance."}, "$insert": {"CARD_short_name": "Bbac_gyrA_AMU"}}, "796": {"$update": {"ARO_description": "iri is a monooxygenase that confers resistance to rifampin found in Rhodococcus hoagii.", "model_sequences": {"$update": {"sequence": {"$update": {"474": {"$update": {"dna_sequence": {"$update": {"accession": "U56415.1"}}}}}}}}}, "$insert": {"CARD_short_name": "iri"}}, "4693": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-66"}}, "591": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1167": {"$update": {"dna_sequence": {"$update": {"accession": "JN790863.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CTX-M-122"}}, "475": {"$update": {"ARO_description": "OXA-106 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1202": {"$update": {"dna_sequence": {"$update": {"accession": "EF650032.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-106"}}, "4931": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-605"}}, "1711": {"$update": {"ARO_description": "AQU-1 is a chromosomal class C beta-lactamase found in clinical Aeromonas dhakensis isolates.", "model_sequences": {"$update": {"sequence": {"$update": {"1113": {"$update": {"dna_sequence": {"$update": {"accession": "AB765395.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AQU-1"}}, "1381": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1275": {"$update": {"dna_sequence": {"$update": {"accession": "M63556.1"}}}}}}}}, "model_name": "CcrA"}, "$insert": {"CARD_short_name": "CcrA"}}, "613": {"$update": {"ARO_description": "VEB-4 is a beta-lactamase found in Proteus mirabilis.", "model_sequences": {"$update": {"sequence": {"$update": {"1498": {"$update": {"dna_sequence": {"$update": {"accession": "EF136375.1"}}}}}}}}, "ARO_category": {"$update": {"36182": {"$update": {"category_aro_description": "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam."}}}}}, "$insert": {"CARD_short_name": "VEB-4"}}, "1710": {"$update": {"ARO_description": "Point mutation in Mycobacterium leprae gyrB resulting in fluoroquinolone resistance.", "model_sequences": {"$update": {"sequence": {"$update": {"2066": {"$update": {"dna_sequence": {"$update": {"accession": "AL450380.1"}}}}}}}}, "model_name": "Mycobacterium leprae gyrB conferring resistance to fluoroquinolones"}, "$insert": {"CARD_short_name": "Mlep_gyrB_FLO"}}, "1717": {"$update": {"ARO_description": "OXA-230 is a beta-lactamase found in A. bereziniae.", "model_sequences": {"$update": {"sequence": {"$update": {"971": {"$update": {"dna_sequence": {"$update": {"accession": "JQ422054.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-230"}}, "3384": {"$insert": {"CARD_short_name": "MCR-1.5"}}, "458": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"325": {"$update": {"dna_sequence": {"$update": {"accession": "AB089595.1"}}}}}}}}}, "$insert": {"CARD_short_name": "tet(B)"}}, "4960": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-634"}}, "5125": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-822"}}, "1716": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1613": {"$update": {"dna_sequence": {"$update": {"accession": "KM087842.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-398"}}, "4398": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6773": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-36"}}, "4399": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6774": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-38"}}, "5638": {"$insert": {"CARD_short_name": "RSA2-1"}}, "1715": {"$update": {"ARO_description": "OXA-73 is a beta-lactamase found in Klebsiella pneumonia.", "model_sequences": {"$update": {"sequence": {"$update": {"1218": {"$update": {"dna_sequence": {"$update": {"accession": "AY762325.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-73"}}, "4441": {"$insert": {"CARD_short_name": "CDD-2"}}, "4390": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-29"}}, "732": {"$update": {"ARO_description": "OXA-237 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1456": {"$update": {"dna_sequence": {"$update": {"accession": "JQ820241.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-237"}}, "5636": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8011": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}}, "$insert": {"CARD_short_name": "RAHN-1"}}, "1714": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"493": {"$update": {"dna_sequence": {"$update": {"accession": "D14532.1"}}}}}}}}}, "$insert": {"CARD_short_name": "ErmW"}}, "4394": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-32"}}, "4395": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-33"}}, "4396": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6771": {"$update": {"NCBI_taxonomy": {"$update": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-34"}}, "4397": {"$update": {"ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "BlaB-35"}}, "1366": {"$update": {"model_sequences": {"$update": {"sequence": {"8150": {"dna_sequence": {"partial": "0", "sequence": "ATGCCTTTTGCCCTCTACATGCTTGCCCTGGCGGTCTTCGTCATGGGCACTTCAGAATTCATGCTCGCGGGATTGCTCCCCGCGATCGCGACCGAACTTGACGTCTCGGTCGGCACTGCGGGCCTGCTGACCTCCGCATTCGCAGTCGGTATGGTCGTCGGCGCGCCAGTGATGGCGGCATTCGCTCGCCGTTGGCCACCGCGGCTCACATTGATCGTTTGCCTTCTCGTGTTCGCGGGAAGCCACGTCATCGGAGCGATGACACCAGTGTTCTCTCTCCTGCTCATCACCCGGGTGCTCAGCGCTCTCGCAAACGCAGGATTCCTCGCCGTAGCACTGAGCACGGCCACTACCCTCGTGCCAGCGAACCAGAAGGGGCGTGCACTGTCGATCCTGCTCTCCGGCACGACGATCGCAACCGTCGTGGGCGTCCCCGCCGGGGCACTGCTCGGCACAGCGCTGGGCTGGCGAACGACGTTCTGGGCGATCGCCATCCTCTGTATTCCCGCGGCCGTTGGAGTCATTCGTGGCGTCACGAACAATGTTGGTCGGAGCGAGACTAGCGCGACCTCACCAAGGCTCCGTGTCGAGCTCAGCCAGTTGGCGACGCCGCGGCTCATCCTGGCCATGGCACTCGGAGCGCTGATCAACGGAGGGACCTTTGCGGCATTCACCTTCCTGGCACCCATCGTGACCGAGACCGCGGGCTTGGCCGAAGCGTGGGTGTCCGTCGCGCTGGTGATGTTCGGCATCGGATCGTTCCTTGGCGTCACGATCGCAGGACGACTATCAGATCAACGACCTGGCCTCGTGCTCGCAGTCGGCGGACCGCTATTGCTGACAGGCTGGATCGTGTTGGCAGTGGTCGCATCTCATCCCGTTGCGCTTATCGTCCTCGTCCTCGTTCAGGGATTCCTGTCGTTCGGCGTCGGCAGTACTCTGATCACGCGTGTGCTGTATGCAGCATCGGGTGCGCCAACGATGGGCGGTTCGTACGCAACCGCAGCATTGAATATCGGAGCTGCAGCGGGGCCCGTGCTTGGTGCGCTCGGGCTCGCGACCGGGCTGGGGCTGCTCGCGCCGGTTTGGGTCGCTTCGGTGCTGACAGCGATCGCTCTCGTCATCATGCTTCTCACCAGACGCGCGCTTACGAAGACCGCGGCGGAGGCCAATTGA", "fmax": "37110", "accession": "AF024666.2", "fmin": "35934", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Corynebacterium striatum", "NCBI_taxonomy_id": "43770", "NCBI_taxonomy_cvterm_id": "39554"}, "protein_sequence": {"accession": "AAG03380.1", "sequence": "MPFALYMLALAVFVMGTSEFMLAGLLPAIATELDVSVGTAGLLTSAFAVGMVVGAPVMAAFARRWPPRLTLIVCLLVFAGSHVIGAMTPVFSLLLITRVLSALANAGFLAVALSTATTLVPANQKGRALSILLSGTTIATVVGVPAGALLGTALGWRTTFWAIAILCIPAAVGVIRGVTNNVGRSETSATSPRLRVELSQLATPRLILAMALGALINGGTFAAFTFLAPIVTETAGLAEAWVSVALVMFGIGSFLGVTIAGRLSDQRPGLVLAVGGPLLLTGWIVLAVVASHPVALIVLVLVQGFLSFGVGSTLITRVLYAASGAPTMGGSYATAALNIGAAAGPVLGALGLATGLGLLAPVWVASVLTAIALVIMLLTRRALTKTAAEAN"}}}}}}, "$insert": {"CARD_short_name": "cmx"}}, "1367": {"$insert": {"CARD_short_name": "oleD"}}, "1364": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1281": {"$update": {"dna_sequence": {"$update": {"accession": "KF526114.1"}}}}}}}}}, "$insert": {"CARD_short_name": "CMY-101"}}, "1365": {"$update": {"ARO_description": "AAC(6')-I30 is an integron-encoded aminoglycoside acetyltransferase in S. enterica.", "model_sequences": {"$update": {"sequence": {"$update": {"399": {"$update": {"dna_sequence": {"$update": {"accession": "AY289608.1"}}}}}}}}}, "$insert": {"CARD_short_name": "AAC(6')-I30"}}, "1362": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1260": {"$update": {"dna_sequence": {"$update": {"accession": "KF148593.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-31"}}, "1363": {"$update": {"ARO_description": "CARB-1 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1855": {"$update": {"dna_sequence": {"$update": {"accession": "AF313471.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "CARB-1"}}, "474": {"$update": {"ARO_description": "dfrD is a plasmid-encoded dihydrofolate reductase found in Listeria monocytogenes.", "model_sequences": {"$update": {"sequence": {"$update": {"683": {"$update": {"dna_sequence": {"$update": {"accession": "U43152.1"}}}}}}}}}, "$insert": {"CARD_short_name": "dfrD"}}, "1361": {"$update": {"ARO_description": "OXA-223 is a beta-lactamase found in A. baumannii.", "model_sequences": {"$update": {"sequence": {"$update": {"1683": {"$update": {"dna_sequence": {"$update": {"accession": "JN248564.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "OXA-223"}}, "4444": {"$update": {"ARO_category": {"$update": {"41356": {"$update": {"category_aro_name": "CepA beta-lactamase", "category_aro_description": "CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin."}}}}}, "$insert": {"CARD_short_name": "CepA-49"}}, "478": {"$insert": {"CARD_short_name": "AAC(3)-IIa"}}, "479": {"$update": {"ARO_description": "IMP-29 is a beta-lactamase found in Pseudomonas aeruginosa.", "model_sequences": {"$update": {"sequence": {"$update": {"1015": {"$update": {"dna_sequence": {"$update": {"accession": "JQ041634.1"}}}}}}}}, "ARO_category": {"$update": {"36017": {"$update": {"category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}}}}}, "$insert": {"CARD_short_name": "IMP-29"}}, "5258": {"$insert": {"CARD_short_name": "PDC-122"}}, "1368": {"$update": {"model_sequences": {"$update": {"sequence": {"8212": {"dna_sequence": {"partial": "0", "sequence": "GTGTCGAATGTCACGTCGTTTCGGTCTGAATTAAAACAACTCTTCCATTTAATGTTACCTATTTTAATTACGCAGTTTGCTCAAGCAGGGTTCGGGTTAATTGATACCATTATGGCTGGGCATTTATCTGCCGCAGACTTAGCCGCTATTGCGGTAGGTGTAGGCTTATGGATTCCAGTCATGCTCTTGTTCAGTGGCATCATGATTGCAACCACACCATTAGTTGCCGAAGCAAAAGGCGCTAGAAATACAGAGCAAATTCCAGTGATTGTCCGCCAATCATTATGGGTTGCAGTAATTCTAGGGGTATTGGCAATGCTCATTTTGCAGCTTATGCCATTTTTCTTACATGTGTTTGGCGTACCAGAAAGTTTACAACCTAAAGCCAGTTTATTCTTACATGCAATTGGTTTGGGTATGCCCGCTGTAACCATGTATGCAGCGCTCCGAGGCTATTCCGAAGCATTAGGCCATCCCCGCCCTGTCACGGTCATTAGCTTACTAGCCTTAGTGGTTTTAATCCCGCTTAACATGATTTTTATGTATGGCTTAGGACCAATACCTGCTTTGGGTAGCGCAGGCTGTGGTTTTGCAACATCCATTTTACAGTGGCTGATGCTCATTACGTTAGCAGGCTATATTTATAAGGCTTCGGCTTATCGAAACACATCTATTTTTAGCAGATTCGATAAAATTAGCCTGACTTGGGTTAAAAGAATTTTACAGCTCGGCCTGCCAATTGGTTTAGCTGTGTTTTTTGAAGTGAGTATTTTTAGTACAGGGGCATTGGTCCTTAGCCCTCTAGGGGAAGTCTTTATTGCCGCACACCAAGTAGCAATTTCAGTCACTTCGGTACTGTTTATGATTCCACTTTCTCTTGCCATTGCTTTAACCATTCGCGTGGGGACGTATTATGGTGAAAAGAACTGGGCTTCCATGTACCAAGTACAGAAAATTGGTCTAAGCACAGCAGTATTTTTTGCTCTATTGACCATGTCTTTTATTGCTTTAGGCCGTGAACAAATTGTCTCGGTTTATACTCAAGATATAAATGTTGTGCCGGTTGCCATGTATTTGCTCTGGTTTGCAATGGCATATCAATTAATGGATGCTCTACAAGTCAGCGCTGCCGGCTGTTTAAGAGGTATGCAAGATACTCAGGCACCGATGTGGATCACCTTAATGGCGTATTGGGTAATTGCTTTTCCAATCGGTCTTTATTTAGCGCGTTATACCGATTGGGGCGTAGCTGGTGTGTGGTTAGGTTTAATTATTGGTTTAAGTATTGCCTGTGTTTTATTGCTATCACGACTCTATTTGAATACCAAACGTTTAAGTCAAACCTAA", "fmax": "1533", "accession": "AB204810.2", "fmin": "186", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470", "NCBI_taxonomy_cvterm_id": "35507"}, "protein_sequence": {"accession": "BAD89844.2", "sequence": "MSNVTSFRSELKQLFHLMLPILITQFAQAGFGLIDTIMAGHLSAADLAAIAVGVGLWIPVMLLFSGIMIATTPLVAEAKGARNTEQIPVIVRQSLWVAVILGVLAMLILQLMPFFLHVFGVPESLQPKASLFLHAIGLGMPAVTMYAALRGYSEALGHPRPVTVISLLALVVLIPLNMIFMYGLGPIPALGSAGCGFATSILQWLMLITLAGYIYKASAYRNTSIFSRFDKISLTWVKRILQLGLPIGLAVFFEVSIFSTGALVLSPLGEVFIAAHQVAISVTSVLFMIPLSLAIALTIRVGTYYGEKNWASMYQVQKIGLSTAVFFALLTMSFIALGREQIVSVYTQDINVVPVAMYLLWFAMAYQLMDALQVSAAGCLRGMQDTQAPMWITLMAYWVIAFPIGLYLARYTDWGVAGVWLGLIIGLSIACVLLLSRLYLNTKRLSQT"}}}}}, "ARO_category": {"$update": {"37250": {"$update": {"category_aro_class_name": "Antibiotic"}}, "43746": {"$update": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}}, "$delete": ["36193"]}}, "$insert": {"CARD_short_name": "abeM"}}, "1369": {"$update": {"ARO_description": "QnrB69 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii.", "model_sequences": {"$update": {"sequence": {"$update": {"278": {"$update": {"dna_sequence": {"$update": {"accession": "KC580658.1"}}}}}}}}, "ARO_category": {"$update": {"36558": {"$update": {"category_aro_description": "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics."}}}}}, "$insert": {"CARD_short_name": "QnrB69"}}}, "$delete": ["3704"], "$insert": {"5755": {"model_id": "5755", "ARO_accession": "3007055", "model_param": {"40394": {"param_value": {"12411": "Q50STOP", "12482": "A50STOP", "12412": "Q5STOP", "12438": "N73STOP"}, "param_type_id": "40394", "param_type": "nonsense mutation", "param_description": "A nucleotide substitution resulting in a change from an amino acid codon to a STOP codon. Nonsense mutations truncate protein translation prematurely, resulting in a defective or completely inactive protein. In CARD, nonsense mutations may be attached to models using the notation: [wild type amino acid][position][STOP] (e.g. Q42STOP). This parameter is not currently used in detection algorithms."}, "41344": {"param_value": {"12407": "21TGATCA"}, "param_type_id": "41344", "param_type": "insertion mutation from peptide sequence", "param_description": "A subtype of the insertion mutation detection model parameter. This parameter is used when a set of insertion mutations is reported in a peptide sequence format. These are specific to codon insertions, where a multiple of three nucleotides are inserted. This does not cause a frameshift mutation. Mutation parameters of this type are reported in CARD with the notation: [+][AAs][position range]."}, "40494": {"param_value": {"12483": "A96fs", "12480": "G112fs", "12481": "A190fs", "12484": "T62fs", "12485": "T162fs", "12479": "T38fs", "12478": "C18fs", "12436": "L13fs"}, "param_type_id": "40494", "param_type": "frameshift mutation", "param_description": "A frameshift is a type of genetic mutation caused by a nucleotide insertion or deletion that does not equal 3 bases. This changes the grouping of codons and thus the reading frame during translation, resulting in an incomplete or inactive protein product. Many frameshift mutations generate downstream STOP codons, resulting in premature peptide translation termination. Frameshifts may also confer antibiotic resistance through partial or total protein loss-of-function. Frameshift mutations are included with relevant models when applicable, with the following notation: [wild-type AA][position]fs;[[wild-type AA][position]STOP], where AA is an amino acid. If the premature STOP codon position is unknown or does not exist, [wild-type AA][position]fs is sufficient. Termination can also be denoted as: Ter[position]fs. This parameter is currently not included in detection algorithms."}, "40590": {"param_value": {"12442": "45615,Q11STOP+45620,Q5STOP"}, "param_type_id": "40590", "param_type": "co-dependent nonsense SNP", "param_description": "An AMR detection model parameter to describe concurrent nonsense mutations in multiple genes which produce a resistance phenotype. That is, either mutation independently will not confer resistance but co-mutation in a set of genes does. These mutation parameters are documented in CARD with the notation: [cvterm-id-gene-1],[gene-1-nonsenseSNP]+[cvterm-id-gene-2],[gene-2-nonsenseSNP]+ ... +[cvterm-id-gene-n],[gene-n-nonsenseSNP] e.g. 39879,G247S+40052,D500STOP. This is currently (August 2017) no algorithm for model detection with this parameter."}, "41342": {"param_value": {"12406": "110C-118G"}, "param_type_id": "41342", "param_type": "deletion mutation from peptide sequence", "param_description": "A subtype of the deletion mutation detection model parameter. This parameter is used when a set of deletion mutations is reported in a peptide sequence format. These are specific to codon deletions, where a multiple of 3 nucleotides are deleted. Mutations of this type are reported in the CARD with the notation: [-][AAs][position range]."}, "40438": {"param_value": {"12441": "45615,N73STOP+45620,R3T", "12453": "45615,E27V+45620,V44G,Y60F", "12449": "45615,M21V,A80T,Q119STOP+45620,A70V"}, "param_type_id": "40438", "param_type": "co-dependent single resistance variant", "param_description": "A model parameter to describe mutations in multiple genes or proteins where resistance is co-dependent on each. For example, the G247S SNP in M. tuberculosis gyrA does not confer resistance to fluoroquinolones. However, when the D500N SNP is also present in gyrB, resistance is conferred. In this case, gyrA G247S is co-dependent on gyrB D500N to confer resistance. This parameter is noted on relevant models with the following notation: [cvterm-id-gene-1],[gene-1-SNP]+[cvterm-id-gene-2],[gene-2-SNP]+ ... +[cvterm-id-gene-n],[gene-n-SNP] e.g. 39879,G247S+40052,D500N. This parameter is not currently included in any detection algorithms."}, "snp": {"param_type": "single resistance variant", "param_value": {"12395": "R90K", "12446": "G189S", "12408": "A1G", "12500": "C49T", "12506": "H97Y", "12398": "A118T", "12399": "A118S", "12396": "H97T", "12397": "S108A", "12394": "T31E", "12401": "K64N", "12392": "R16H", "12393": "C19Y", "12404": "A68E", "12405": "A67V", "12497": "T184G", "12496": "G47A", "12499": "C273T", "12498": "G60A", "12444": "C148Y", "12505": "L210V", "12504": "D59N", "12402": "P106S", "12386": "R16C", "12400": "G189C"}, "clinical": {"12395": "R90K", "12446": "G189S", "12408": "A1G", "12500": "C49T", "12506": "H97Y", "12398": "A118T", "12399": "A118S", "12396": "H97T", "12397": "S108A", "12394": "T31E", "12401": "K64N", "12392": "R16H", "12393": "C19Y", "12404": "A68E", "12405": "A67V", "12497": "T184G", "12496": "G47A", "12499": "C273T", "12498": "G60A", "12444": "C148Y", "12505": "L210V", "12504": "D59N", "12402": "P106S", "12386": "R16C", "12400": "G189C"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}, "40330": {"param_value": {"12448": "R16H,S108A,R176C,S196N"}, "param_type_id": "40330", "param_type": "multiple resistance variants", "param_description": "A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms."}, "blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "The rdxA gene in Helicobacter pylori encodes an NADPH nitroreductase. Mutations in this gene are associated with metronidazole resistance.", "model_sequences": {"sequence": {"8315": {"dna_sequence": {"partial": "0", "sequence": "ATGAAATTTTTGGATCAAGAAAAAAGAAGACAATTATTAAACGAGCGCCATTCTTGCAAGATGTTTGATAGCCATTATGAGTTTTCTAGCACAGAATTAGAAGAAATCGCTGAAATCGCCAGGCTATCGCCAAGCTCTTACAACACGCAGCCATGGCATTTTGTGATGGTTACTGATAAGGATTTAAAAAAACAAATTGCAGCGCACAGCTATTTCAATGAAGAGATGATTAAAAGCGCTTCAGCGTTAATGGTGGTATGCTCTTTAAGACCCAGCGAGTTGTTACCACACGGCCACTACATGCAAAATCTCTATCCGGAGTCTTATAAAGTTAGAGTGATCCCCTCTTTTGCTCAAATGCTTGGCGTGAGATTCAACCACAGCATGCAAAGATTAGAAAGCTATATTTTAGAGCAATGCTATATCGCTGTGGGGCAAATTTGCATGGGCGTGAGCTTAATGGGATTGGATAGTTGCATTATTGGAGGCTTTGATCCTTTAAAGGTGGGCGAAGTTTTAGAAGAGCGTATCAATAAGCCTAAAATCGCATGCTTGATCGCTTTGGGCAAGAGGGTGGCAGAAGCGAGTCAAAAATCAAGAAAATCAAAAGTTGATGCGATTACTTGGTTGTGA", "fmax": "1014185", "accession": "NC_000915.1", "fmin": "1013552", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori", "NCBI_taxonomy_id": "210", "NCBI_taxonomy_cvterm_id": "36906"}, "protein_sequence": {"accession": "WP_000670110.1", "sequence": "MKFLDQEKRRQLLNERHSCKMFDSHYEFSSTELEEIAEIARLSPSSYNTQPWHFVMVTDKDLKKQIAAHSYFNEEMIKSASALMVVCSLRPSELLPHGHYMQNLYPESYKVRVIPSFAQMLGVRFNHSMQRLESYILEQCYIAVGQICMGVSLMGLDSCIIGGFDPLKVGEVLEERINKPKIACLIALGKRVAEASQKSRKSKVDAITWL"}}}}, "model_name": "Helicobacter pylori rdxA mutation conferring resistance to metronidazole", "ARO_category": {"41239": {"category_aro_name": "nitroimidazole antibiotic", "category_aro_cvterm_id": "41239", "category_aro_accession": "3004115", "category_aro_class_name": "Drug Class", "category_aro_description": "Nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity, classified with respect to the location of the nitro functional group."}, "45616": {"category_aro_name": "Antibiotic resistant Helicobacter pylori nitroreductase", "category_aro_cvterm_id": "45616", "category_aro_accession": "3007056", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Inactivation of the oxygen-insensitive NADPH nitroreductases in Helicobacter pylori play a role in metronidazole resistance."}, "35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "37033": {"category_aro_name": "metronidazole", "category_aro_cvterm_id": "37033", "category_aro_accession": "3000689", "category_aro_class_name": "Antibiotic", "category_aro_description": "Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death."}}, "ARO_name": "Helicobacter pylori rdxA mutation conferring resistance to metronidazole", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "Hpyl_rdxA_MTZ", "ARO_id": "45615", "model_type_id": "40292"}, "5740": {"model_id": "5740", "ARO_accession": "3007029", "model_param": {"blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "salE is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins.", "model_sequences": {"sequence": {"8294": {"dna_sequence": {"partial": "0", "sequence": "ATGTCTTTTTATTTTGCCCAAAAACCTTTTGAAATGTTTGGAAAAACACTGATTCAGTCAGTGGATTTACAATTTGAAAAGGGTGAACATATTGCTGTGATTGGTAATAATGGCGTTGGGAAAACGACTTTATTAAAAGCATTAAATAATAAGTATAAAGAAGATACTTATTTGATGGACCAAAACATGACTACCTTTGGAAACATGACGGGGATAGACTATGTAATAAGCTTAAACACAGAATTGTTTCATTTAAAACAAGCGTTAATGGATAACTATGAAAAAGTTTCAGATTATATCGCTTTAAATGGCTATGAATTTGAACAAACCATTATAACTAAAGCGAAGCAAATGGCTCTAACGGAAGCAGATCTTGACAAACCAATTAAAGTATTAAGCGGCGGCCAACAAACTAGGCTTGCTTTATTGAGAGCATTTATTTCAAACAAACCATTGATATTGCTGGACGAACCAACCAATCATTTAGACCAAGAAATGATAGACCAATTGATTAACCATATACAACAATCAAAACGCACAATCATATATGTGTCGCATCATAGAGGATTTATAGATCAGACCGCGAGTCATGTTATAGAAATAACACCCGAAAGTACAAGAAAATTTAATGGCAATTATAAGCAATACAAAGAGATAAAAGATTTAGAAAGTCAAACAGAACAACGTATATATAATAAACAACAAAAAGAAATACAAGACCTCGAACGTACGATCAAACGCGTACAAACATGGCATCATTCTGCTCAGCAAAAAGCAAGTGTACGTAATCCGATTGAACAGAAAAAGTTGAGCAAATTAGCGCAAAGGGCAAAGGTGAAGGAAAAACAATTAAACCAAAAATTACAAGAAAAACATATTCAAGAACCGAGTAAAGAAACAAAGTCATATTACTTTAGTCATCAGACTAGCCTTCCTAAACGTTTCTTAATTCGTTTTGAAGATGTTAGCGTTAATATTGATGGACAAGCTATATATAAACACGCTCATTTTGAAATGAAACAAAATGAAAATATATTACTTACTGGTCCAAATGGAAGTGGTAAATCGCTTTTCATCGCTTTGATTAGACAGCATTTATCACCAGACGAAGGTATTATAGAGATTACGCCATCGTTAAAGATAGGTTACTTTGATCATACAAATAACAATCTAAATGAAGCAGAATCTCCATTATCAATGTTGTTAGTAAGAACTAACATAACGCGTAGCCAAGCGCAGACATTACTTGCTTCATTTAATTTTGATAAGGATCAAATCAAAAAACCAATTCGCTATTTGTCTATGGGGGAAAAAAGTCGTTTACAATTTGTATTATTATATTTTTCAGGTGCTAATTTATTAGTATTGGATGAGCCTACGAACTATTTTGATATTGTAACTCAAGATTTAATTTTAAGTATGATTCAAAGTTTTACCGGTCAAGTATTGATTGTTACACATGATTCATATTTACAATCTCAATTTAAAGCTGTACATTGGGAAATAAAAAATCAACAACTTTATAATGTATCTTTAACTCATACGCGTGAATCAAACTTAGATGAAACCCTTAAGTTACTAGGTGAATATAAATTTATAGATGAAAATGGTCATTTTGAAACAGACAACTAG", "fmax": "1366352", "accession": "NZ_CP017459.1", "fmin": "1364720", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus nepalensis", "NCBI_taxonomy_id": "214473", "NCBI_taxonomy_cvterm_id": "45588"}, "protein_sequence": {"accession": "WP_096809342.1", "sequence": "MSFYFAQKPFEMFGKTLIQSVDLQFEKGEHIAVIGNNGVGKTTLLKALNNKYKEDTYLMDQNMTTFGNMTGIDYVISLNTELFHLKQALMDNYEKVSDYIALNGYEFEQTIITKAKQMALTEADLDKPIKVLSGGQQTRLALLRAFISNKPLILLDEPTNHLDQEMIDQLINHIQQSKRTIIYVSHHRGFIDQTASHVIEITPESTRKFNGNYKQYKEIKDLESQTEQRIYNKQQKEIQDLERTIKRVQTWHHSAQQKASVRNPIEQKKLSKLAQRAKVKEKQLNQKLQEKHIQEPSKETKSYYFSHQTSLPKRFLIRFEDVSVNIDGQAIYKHAHFEMKQNENILLTGPNGSGKSLFIALIRQHLSPDEGIIEITPSLKIGYFDHTNNNLNEAESPLSMLLVRTNITRSQAQTLLASFNFDKDQIKKPIRYLSMGEKSRLQFVLLYFSGANLLVLDEPTNYFDIVTQDLILSMIQSFTGQVLIVTHDSYLQSQFKAVHWEIKNQQLYNVSLTHTRESNLDETLKLLGEYKFIDENGHFETDN"}}}}, "model_name": "salE", "ARO_category": {"37713": {"category_aro_name": "retapamulin", "category_aro_cvterm_id": "37713", "category_aro_accession": "3001314", "category_aro_class_name": "Antibiotic", "category_aro_description": "Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections."}, "37014": {"category_aro_name": "pleuromutilin antibiotic", "category_aro_cvterm_id": "37014", "category_aro_accession": "3000670", "category_aro_class_name": "Drug Class", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes."}, "37015": {"category_aro_name": "tiamulin", "category_aro_cvterm_id": "37015", "category_aro_accession": "3000671", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "41687": {"category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_cvterm_id": "41687", "category_aro_accession": "3004469", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins."}, "35999": {"category_aro_name": "antibiotic target protection", "category_aro_cvterm_id": "35999", "category_aro_accession": "0001003", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "36218": {"category_aro_name": "oxazolidinone antibiotic", "category_aro_cvterm_id": "36218", "category_aro_accession": "3000079", "category_aro_class_name": "Drug Class", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use."}, "36526": {"category_aro_name": "phenicol antibiotic", "category_aro_cvterm_id": "36526", "category_aro_accession": "3000387", "category_aro_class_name": "Drug Class", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "salE", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "salE", "ARO_id": "45573", "model_type_id": "40292"}, "5742": {"model_id": "5742", "ARO_accession": "3007041", "model_param": {"blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "Erm(52) is an Erm ribosomal RNA methyltransferase.", "model_sequences": {"sequence": {"8296": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAATCTTGGATATTCACAAAATTTTTTGGTTAATAAAAAGTTGGTAGAACGTTTAATAAGCAAGTCAAATATTGATGTAACAGATTATGTTATTGAAATTGGTCCTGGAAAAGGGATAATAACAGATGTACTTTCTCAGCATGCTGGAGAGGTTGTTGCAGTTGAATATGATCAAGAATTATATAATAATTTAGTAAGATATCACAGTCATGATAATGTTACATATATATTTGGTGATTTTTTAAAATATAAGTTGCCTTTAAATCGCAGATATAAAATATTCTCCAATATTCCTTTTCAGATAACAGCGGATATTATTAGGAAATTAACAGACGATGTAAATCCACCATCAGATATAAATATCATAATTCAAAGAGAGGCAGCTAAAAAGAATTGCGGTATTCCATTACAAAAATATGAAGGTTTTCGTGCTGCTATAATAAAGGCACAATATAAGGTAGAAATTACACATAGTTTTAAAAGGAGCGATTTTTTTCCTTCGCCTAATGTTGATACAGTTATGCTTCATATGCAGTTATGGGATGATAGATTGAGTGGTGATGATCTTCAAAATTATAAAGATTTAGTGGCTTTTTTTTACACTAATATTAAAGGAGAGACTGCTAAAGAGAGACTTTCTATTTTATTTTCTAATGAGCAAATCAAAAGATTGGGAAAAGCCAATAGAATTAGTCTTTCAAATTCATATACGTTAATCACGGCCGAGCAGTGGATGAATATTTATTATTACTCCAAAATTGGATTGACAGATGAAAAGAAAAAAAAGTTTCAAGATGCATATAAAAAACTTCAAAAAATGAATAAAAAATTGAAAAAGCAAAACAGAACATCTTTACGAAAGTCTAGTAGCAATAAGAAATGTAGAACAAGGATTGATACTTCTAATGGTACAAAAAATAGATAG", "fmax": "930", "accession": "MW269959.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Clostridioides difficile", "NCBI_taxonomy_id": "1496", "NCBI_taxonomy_cvterm_id": "36807"}, "protein_sequence": {"accession": "QQM99828.1", "sequence": "MKNLGYSQNFLVNKKLVERLISKSNIDVTDYVIEIGPGKGIITDVLSQHAGEVVAVEYDQELYNNLVRYHSHDNVTYIFGDFLKYKLPLNRRYKIFSNIPFQITADIIRKLTDDVNPPSDINIIIQREAAKKNCGIPLQKYEGFRAAIIKAQYKVEITHSFKRSDFFPSPNVDTVMLHMQLWDDRLSGDDLQNYKDLVAFFYTNIKGETAKERLSILFSNEQIKRLGKANRISLSNSYTLITAEQWMNIYYYSKIGLTDEKKKKFQDAYKKLQKMNKKLKKQNRTSLRKSSSNKKCRTRIDTSNGTKNR"}}}}, "model_name": "Erm(52)", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36699": {"category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_cvterm_id": "36699", "category_aro_accession": "3000560", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "Erm(52)", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "Erm(52)", "ARO_id": "45600", "model_type_id": "40292"}, "5743": {"model_id": "5743", "ARO_accession": "3007042", "model_param": {"blastp_bit_score": {"param_value": "600", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "msr(G) is a part of the msr subfamily of ABC-F ribosomal protection proteins.", "model_sequences": {"sequence": {"8297": {"dna_sequence": {"partial": "0", "sequence": "ATGGAACAAATCTGTTTTGAATTAGAAAATGTAGAAGTGACATATCTAGATAAAGAGGTTTTAAAGATTGAAAGATTAGCTGTACACCAATTTGACCGTATCGGCATAGTCGGTAAAAATGGTGCAGGTAAAAGCACGTTACTAAAATTACTGGCGGGTATCATTAAGCCAACAACGGGAAAGGTGAATCGGCTTGTTGAGAATGGCTATTTTGAGCAACTTGAAACTCCATCAGTACGTGATGCTGATCCAGTGTTACTTGGAAAATTAGACGTACCAAAAGACTCTAATCAGCTAAGCGGTGGGGAACAAACAAGGATGAAACTCGCTAAATTGTTTACTCATTATTATGAAGCTTTATTAATTGATGAGCCGACTACTCACTTAGACCAAGAGGGGATTTCGTTTTTGCTCGATGAACTTAGGTATTACTATGGAGCGCTTGTATTAATTAGTCATGACCGTTCTGTATTAGATGAACTAGTTACGACAATTTGGGAAGTTCATGAAGGTAAGGTACGAATCTATTCAGGAAATTACAGCGACTACATGGCACAAAAGAAGTTAGAACGTGAACAGCAGAGTCAAGCACATGAACAGTTCATAAAAGAAAAGAGCAGGTTAGAAAAAGCAGCACAAGAAAAAATGAAGAAAGCTGAAAAAGTTGCACAAGCAGGTCGATTGTCAAAAAAAGATGCGAATGCAAAGCCGGATAAGTCCTTTATGACAAAATCCAAAGGTACGAGCCAAAAAGCTATGCAGCGTGCAGCAAAGGCCATTGAGCAACGAATGGAAAAACTTCAGGAAGTCGATGCTGTAAAAGAGGATAGGCAAATAAACTTCCATCAATCGAGAAATTTAGAGCTGCATAATAAATTTCCGATAATGGCAGACCGATTTACTCTTCAAGTGGATAACAAAGTATTATTAAATGAAGTAAGTTTTCAAATGCCGCTTGGTAAAAAAATTGCAATTTCGGGTAAAAATGGTGCTGGCAAAAGTACTTTACTCCACCATATTGCTATCAATGCGCCAGGTTTAACAATTTCACCAAAAGCAAAAATTGGATACTTTCGTCAAATGAGCTATCAATATACAAGGGATGAAACGGTATTGGAATTTCTGAAAAATCGTTCTGAATACGATGAGAGATTTTTACGAAGCGTTCTACATTCCATGTTGTTTGTCGGCACAGATATATTAAAAAGTGTAAAATCATTAAGTGGTGGTGAAGCGATTCGTCTACAATTATGTCAATTATTTTTAGGAGAGTATAATATTTTATTGTTAGATGAACCAACCAATTTTTTAGATATCTATGCTATTGAAGCGTTAGAAAGATTTATTACAGCATATAAAGGCACTATTATCTTCGTATCACATGATCGCAGGTTTATTGATTGTGTAGCAGATTGTATATATTTCATTGAAGATCAACAGCTAAAATTAAGGGGTTGA", "fmax": "34580", "accession": "CP046364.1", "fmin": "33122", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Macrococcus canis", "NCBI_taxonomy_id": "1855823", "NCBI_taxonomy_cvterm_id": "43299"}, "protein_sequence": {"accession": "QNR09092.1", "sequence": "MEQICFELENVEVTYLDKEVLKIERLAVHQFDRIGIVGKNGAGKSTLLKLLAGIIKPTTGKVNRLVENGYFEQLETPSVRDADPVLLGKLDVPKDSNQLSGGEQTRMKLAKLFTHYYEALLIDEPTTHLDQEGISFLLDELRYYYGALVLISHDRSVLDELVTTIWEVHEGKVRIYSGNYSDYMAQKKLEREQQSQAHEQFIKEKSRLEKAAQEKMKKAEKVAQAGRLSKKDANAKPDKSFMTKSKGTSQKAMQRAAKAIEQRMEKLQEVDAVKEDRQINFHQSRNLELHNKFPIMADRFTLQVDNKVLLNEVSFQMPLGKKIAISGKNGAGKSTLLHHIAINAPGLTISPKAKIGYFRQMSYQYTRDETVLEFLKNRSEYDERFLRSVLHSMLFVGTDILKSVKSLSGGEAIRLQLCQLFLGEYNILLLDEPTNFLDIYAIEALERFITAYKGTIIFVSHDRRFIDCVADCIYFIEDQQLKLRG"}}}}, "model_name": "msr(G)", "ARO_category": {"37014": {"category_aro_name": "pleuromutilin antibiotic", "category_aro_cvterm_id": "37014", "category_aro_accession": "3000670", "category_aro_class_name": "Drug Class", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "41687": {"category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_cvterm_id": "41687", "category_aro_accession": "3004469", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins."}, "35999": {"category_aro_name": "antibiotic target protection", "category_aro_cvterm_id": "35999", "category_aro_accession": "0001003", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "36218": {"category_aro_name": "oxazolidinone antibiotic", "category_aro_cvterm_id": "36218", "category_aro_accession": "3000079", "category_aro_class_name": "Drug Class", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use."}, "36526": {"category_aro_name": "phenicol antibiotic", "category_aro_cvterm_id": "36526", "category_aro_accession": "3000387", "category_aro_class_name": "Drug Class", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "msr(G)", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "msr(G)", "ARO_id": "45601", "model_type_id": "40292"}, "5744": {"model_id": "5744", "ARO_accession": "3007043", "model_param": {"blastp_bit_score": {"param_value": "600", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "msr(I) is part of the msr subfamily of ABC-F ribosomal protection proteins.", "model_sequences": {"sequence": {"8298": {"dna_sequence": {"partial": "0", "sequence": "ATGGAACAAATTTGTTTTGAATTAGAAAAAATTGAAGTAACTTATTTAGATAAAAAAGTATTAGAGATAGATCGTTTAGCAGTTCATCAATTTGATAGAATTGGTATTGTTGGAAAAAATGGTGTTGGTAAGAGTACTCTGCTAAAATTACTTGCAGGTCATATTCAACCTACAGTTGGAAAAGTAAAGCGTCAAGTAGAATATGGTTATTTTGAACAGGTAGAAGGTCCTAAAGATATATCAACAGATCCTAAGTTACTTAGCCAATTACATGTTGATGAGAATTCGAAAGGGCTAAGTGGTGGTGAACAAACAAGATTAAAACTTGCACAGTTATTTACGGACTATTATGAATCTTTATTAATTGATGAGCCAACTACACATTTGGACCAAGAAGGTATATCATTTTTAATAGAAGAGTTGAAATACTATTATGGGGCACTGGTATTAATAAGTCATGACCGATATGTTTTAGATGAACTTGTGACTACAATTTGGGAAGTTGATGATGGGAAAGTAAAAGTATATTCAGGAGATTACAGTGAATATATCGAGCAAAAGAAACTTGAAAGATCAAAACAAACTCAGGCTCATGAACAGTTCTTAAAGGAAAAAAAACGTTTAGAAAAAGCAGCAGAAGAAAAAATGAAAAAAGCAGAAAAAATTGCTAAATCTTCTGCTAAATCAAAAGACTCTAAAGTAAAAGCAAATCGTATGTTTGAATCAAAATCAAAGGGTACAACTCAAAAAGCGTTACAACGTGCTGCTAAGGCTGTTGAACAAAGAGTAAAAAAACTTGAAGTTATAGATGCGCCTAAAAAAGAACAAACTATCCGTTTTCATCAAACAAATATCATACTTGAGTTACATAACAAGTTTCCAATTATGGCTGATCAATTAACGATTACAGTAGGAAATAAGATACTTTTAAACAATGTTAACTTTCAATTTGCATTAGGTGAAACGATTGCTATTACTGGTAAAAATGGTTCTGGGAAATCAACATTAATTCACCACATATTACAACGTGAAAAAGGAATTACTATTTCTCCAAAGGCTGTTATAGGCTCTTATGAGCAGATGGGATATCAATTTAAAACTGATGAAACTGTAATGGACTTTATGAAAAATAGAAGCGATTATGGAGAAAGTAAAATACGTTCTGTACTATATGCTATGAGTTTTACTGGGAATGATTTAAAAAAGAGTGTTCAAAAATTAAGTGGTGGCGAGGCGACTCGTTTAGTCCTATGTCAATTATTTCTAGGAAGATACAACGTTTTGATTTTAGATGAACCTACTAACTTTTTAGATGTTTTTTGTATTGAAGCTTTAGAAACATTTTTAAAAGGCTATGAAGGAACAGTTATACTAATATCACATGATAAAACATTTTTAGATCGTGTAGCTGATAGTGAATACGTTCTAGAAAATCAGAACCTTAAAAAAAATAGATAG", "fmax": "1659615", "accession": "CP065927.1", "fmin": "1658157", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus pyogenes", "NCBI_taxonomy_id": "1314", "NCBI_taxonomy_cvterm_id": "36764"}, "protein_sequence": {"accession": "QQA64075.1", "sequence": "MEQICFELEKIEVTYLDKKVLEIDRLAVHQFDRIGIVGKNGVGKSTLLKLLAGHIQPTVGKVKRQVEYGYFEQVEGPKDISTDPKLLSQLHVDENSKGLSGGEQTRLKLAQLFTDYYESLLIDEPTTHLDQEGISFLIEELKYYYGALVLISHDRYVLDELVTTIWEVDDGKVKVYSGDYSEYIEQKKLERSKQTQAHEQFLKEKKRLEKAAEEKMKKAEKIAKSSAKSKDSKVKANRMFESKSKGTTQKALQRAAKAVEQRVKKLEVIDAPKKEQTIRFHQTNIILELHNKFPIMADQLTITVGNKILLNNVNFQFALGETIAITGKNGSGKSTLIHHILQREKGITISPKAVIGSYEQMGYQFKTDETVMDFMKNRSDYGESKIRSVLYAMSFTGNDLKKSVQKLSGGEATRLVLCQLFLGRYNVLILDEPTNFLDVFCIEALETFLKGYEGTVILISHDKTFLDRVADSEYVLENQNLKKNR"}}}}, "model_name": "msr(I)", "ARO_category": {"37014": {"category_aro_name": "pleuromutilin antibiotic", "category_aro_cvterm_id": "37014", "category_aro_accession": "3000670", "category_aro_class_name": "Drug Class", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "41687": {"category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_cvterm_id": "41687", "category_aro_accession": "3004469", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins."}, "35999": {"category_aro_name": "antibiotic target protection", "category_aro_cvterm_id": "35999", "category_aro_accession": "0001003", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "36218": {"category_aro_name": "oxazolidinone antibiotic", "category_aro_cvterm_id": "36218", "category_aro_accession": "3000079", "category_aro_class_name": "Drug Class", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use."}, "36526": {"category_aro_name": "phenicol antibiotic", "category_aro_cvterm_id": "36526", "category_aro_accession": "3000387", "category_aro_class_name": "Drug Class", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "msr(I)", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "msr(I)", "ARO_id": "45602", "model_type_id": "40292"}, "5745": {"model_id": "5745", "ARO_accession": "3007044", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "mefF is an mef efflux pump protein.", "model_sequences": {"sequence": {"8299": {"dna_sequence": {"partial": "0", "sequence": "ATGAATAATATGAATTGGAAACGGAAATTTATTGCGATTTTTACAGGGCAGTTCTTTTCACTATTAAGCAGTGCTGCTGTTCAATTTAGTATCATTTGGTGGTTAACAGATACATCAGGAGGTTCTCCACTGATTTTAACATTAGCAGGACTGGCTGGATTTATGCCACAAGCATTGTTAGGTCCTTTTGCAGGAACTATTACTGATCGTTATTCACGAAAAGTGATTATGATAATTGCAGATATGACGGTTGCACTTGGAAGTTTAGCTTTATTTGTATCAATGTATTTTTATGATCCGAGTATTATATTGGTGATAATTGTATTGATCGTTCGTTCATTAGCAACTGCATTCCATATGCCGGCTATGCAAGCGTCTATTCCACTAATAGCCCCAAAAGAGCATTTGACAAAAGTTTCTGGATGGGGACAGACAGTGGCTTCTATATCAAATATTGTTGGTCCAGCAGCGGGGATGTCATTACTAGCGATAAGCTCCGTTGAGTGGGTTCTATTACTAGATGTCTTTGGGGCAGTAATTGCTAGTAGTATTTTGCTATTTATTCACATTCCAAATGTACAGAGTTCAGAAACTGTTGATTCTTCTAGTTTTATCAGCGATATGAAAGAAGGATATCATGCACTTGTAAAACATCCTGTTTTATTAAGGTTAACAGTCACGATTACGATTGTTTCGGTGCTGTATATTCCGCTAGGCACTTACTTTCCGCTTATGACACGAAATCATTTCGAGAAGGGCGTAGTTGAAGCTGGAATAATCGAAATTGTTTTTGCTGTTGGCCTCATCTTTGGTGGTATATTAATGGGGATTTTCGGAGATCGATTTGAAAAATTGAAACTCATTGTTAGCGGAATGATACTGATGGGGATTGCCTTATTCATTTCTGGCACACTTCCATCAACTTTATTCTATGGATTTATCGTAATGGCTGGTCTAGTGGGATTGTCTGGTCCATTATTTTCAGCTCCGTTTTATGCTCTTATCCAAACCGAAATTGAACCTCATTTACTTGGGAGAGTGTTTAGTTTTGTTGGAAGTTTGGCATTACTTGCAACACCGTTGGGTTACGCATTTGCTGGGGTTCTGATCCACTTAACAAATGTGGCCGTATTATTTTTGATTACAGGTATATTAATTGTATTAAATGCTGTTATCGTAAGGAAAGCAAAATAG", "fmax": "33005", "accession": "CP046364.1", "fmin": "31811", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Macrococcus canis", "NCBI_taxonomy_id": "1855823", "NCBI_taxonomy_cvterm_id": "43299"}, "protein_sequence": {"accession": "QNR09091.1", "sequence": "MNNMNWKRKFIAIFTGQFFSLLSSAAVQFSIIWWLTDTSGGSPLILTLAGLAGFMPQALLGPFAGTITDRYSRKVIMIIADMTVALGSLALFVSMYFYDPSIILVIIVLIVRSLATAFHMPAMQASIPLIAPKEHLTKVSGWGQTVASISNIVGPAAGMSLLAISSVEWVLLLDVFGAVIASSILLFIHIPNVQSSETVDSSSFISDMKEGYHALVKHPVLLRLTVTITIVSVLYIPLGTYFPLMTRNHFEKGVVEAGIIEIVFAVGLIFGGILMGIFGDRFEKLKLIVSGMILMGIALFISGTLPSTLFYGFIVMAGLVGLSGPLFSAPFYALIQTEIEPHLLGRVFSFVGSLALLATPLGYAFAGVLIHLTNVAVLFLITGILIVLNAVIVRKAK"}}}}, "model_name": "mefF", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "mefF", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "mefF", "ARO_id": "45603", "model_type_id": "40292"}, "5746": {"model_id": "5746", "ARO_accession": "3007033", "model_param": {"blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "Erm(51) is an Erm ribosomal RNA methyltransferase.", "model_sequences": {"sequence": {"8300": {"dna_sequence": {"partial": "0", "sequence": "ATGCCTACCTACAGGCCGAACAAGGGCCGTCACGAGAACGGCCAGAACTACCTCGTCAACAAGTCAATGATTAAGAAGGTCGTTGACCTTGTCCCTGTCAGTGCGTCCGTCCCGGTCATAGAGATCGGCCCGGGACACGGGGCGCTGACCTTTCCCCTCCAGGACCGTGTCCTGGCTACCGGTGGATCGTTGACCGCCGTCGAGATCGACCCGGCCTCCGTCCGGTGGCTGGAGGAGCGGCTGCGCCCGGAGGTTCACCTGTACGAGCAGGACGTCCTTGATTTTGTGCTGCCGGACGGCCCGCACGTCCTGGTGGGGAACCTGCCGTTTCACCTGACCACCGCGATCCTGCGGCACGTCCTTCACTCACCGGGGTGGACTCACGCGGTCTTCCTGGTGCAGTGGGAGGTCGCGCGTCGCCGCGCCGGCGTCGGTGGTGCCACGATGATGACAGCCCAGTGGTGGCCCTGGTTCGACTTCGAACAGCACGGGCGAATACCATCCACACATTTCCGTCCCCGCCCCACCGTCGACGCCGGTGTCCTGGTGATGCGTCGCCGGGAAGAGCCTCTCGTCAACTGGTCGGAGCGTGCGCGGTACGCGTCGTTCGTCCATGCCGTGTTCACCGGCAAGGGCCGAGGCATCGCCGACATCGTGTCCCGGGTCGTGGGGCGTCGGCGTGAACGACGGTGTGCTGAGGTCCTGCGTGAGGCCGGTGTTCCGGCAAACGCACTGCCGAAACAGTTGGACGCGGGGCAGTGGGCCACACTGTTTAAGGCCGTGGGGCGCTAA", "fmax": "792", "accession": "MN928789.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Rhodococcus hoagii", "NCBI_taxonomy_id": "43767", "NCBI_taxonomy_cvterm_id": "36897"}, "protein_sequence": {"accession": "QKE44141.1", "sequence": "MPTYRPNKGRHENGQNYLVNKSMIKKVVDLVPVSASVPVIEIGPGHGALTFPLQDRVLATGGSLTAVEIDPASVRWLEERLRPEVHLYEQDVLDFVLPDGPHVLVGNLPFHLTTAILRHVLHSPGWTHAVFLVQWEVARRRAGVGGATMMTAQWWPWFDFEQHGRIPSTHFRPRPTVDAGVLVMRRREEPLVNWSERARYASFVHAVFTGKGRGIADIVSRVVGRRRERRCAEVLREAGVPANALPKQLDAGQWATLFKAVGR"}}}}, "model_name": "Erm(51)", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36699": {"category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_cvterm_id": "36699", "category_aro_accession": "3000560", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "Erm(51)", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "Erm(51)", "ARO_id": "45592", "model_type_id": "40292"}, "5747": {"model_id": "5747", "ARO_accession": "3007047", "model_param": {"blastp_bit_score": {"param_value": "100", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "mefH is an mef efflux pump protein.", "model_sequences": {"sequence": {"8301": {"dna_sequence": {"partial": "0", "sequence": "ATGGGAATTTCGCTATTTTTAGAATTGCCTGCAATAGTTTCCTACTGGGTAGTTACAGTGATGTGCTTTGTGGCTATGGGTGTATCTACTATGTTTGTTGTTCAAATTTACACTCTTGTTCAGACACAAACACCACCGCAATTAGTAGGAAAGATAATGGCTACGCTGGTAGCAGTTGCTATGTGCGGTCAACCTATTGGACAAATGGTTTACGGTATTTTATTCGATGTATTTATACAAGAAACATGGGTTGTTATGTTTGTAGCTTCTATTGCTTCAATCATGATTTCAATATATTCAAAAAGAATTTTTCAAAAGTTAGAGATATAA", "fmax": "330", "accession": "MW269960.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Clostridioides difficile", "NCBI_taxonomy_id": "1496", "NCBI_taxonomy_cvterm_id": "36807"}, "protein_sequence": {"accession": "QQM99829.1", "sequence": "MGISLFLELPAIVSYWVVTVMCFVAMGVSTMFVVQIYTLVQTQTPPQLVGKIMATLVAVAMCGQPIGQMVYGILFDVFIQETWVVMFVASIASIMISIYSKRIFQKLEI"}}}}, "model_name": "mefH", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "mefH", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "mefH", "ARO_id": "45606", "model_type_id": "40292"}, "5748": {"model_id": "5748", "ARO_accession": "3007049", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "mefJ is an mef efflux pump protein.", "model_sequences": {"sequence": {"8302": {"dna_sequence": {"partial": "0", "sequence": "ATGGAAAACAACAAATGGAAGCAGAAGTTTTTTGCAATATATACAGGACAATTCTTTTCACTATTAAGTAGTGCGGCCGTTCAATTTGGTATTATTTGGTGGCTAACTGATAAAACTGGTGGTTCACCATTGCTTCTAACACTAGCAGGACTTGCAGGTTTTTTACCACAAGCATTAGTAGGACCTTTTGCTGGCACGATTACAGACCGTTATTCACGGAAGTTTTTGATGATTTCAGCAGATATGACTGTTGCGTTAGGTAGTTTAATTTTATTTTTAATATTGCATTTCTATGAGGCTAATATCATTTTTGTAATTCTGATTTTAGCACTTAGATCATTAGCAACTGCTTTTCATATGCCAGCAATGCAAGCATCAATTCCTTTACTTGCCCCTGAAGAAGCATTGACAAAGGTCGCTGGTTGGGGGCAAATGGTAGCATCCGTTTCTAATATAGTAGGACCAGCTGTAGGGATGTCAATTCTTTCAGTGAGCTCAATTAAATGGGTACTACTTTTAGATATACTTGGAGCTGTAGTTGCAAGTGGGATTTTACTTTTTATAAATATACCTAAAATACAAAAAACTGAATCTGTTGAACTTACAAGTTTTTTTGTAGAAATGAAAGAAGGGTATAATGCCCTTGTTAATCATCCTATCTTGTTGAAACTTACAATACTTATGACAATCGTAGCAGTCCTATACATACCACTTGGAACTTACTTCCCACTTATGACAAGAAATCATTTTGGGAAAGGTGTTGTTGAAGCTGGTACAGTAGAGATTGCATTTGCTATCGGTTTAATAGTAGGCGGTTCATTGTTAGGTATAATAGGTGATAAATTTGAAAAAGTGAAGACAATGGCAATTGGAATGCTATTGATGGGACTGGCACTATTTTTCTCTGGTCTTCTCTCACCATCACTTTTCTTTATCTTTATAATTTTGTCCGGATTGGTTGGATTTTCAGGACCTTTATTTTCTGCACCATTCTATGCTTATATTCAAACTGAGATTGAGCCACAATTATTAGGAAGAATTTTCAGTTTTGTAACAAGTCTCTCACTTTTAGCCACGCCAATTGGATATGCATTATCTGGTTTACTAATTGAATTTACTAGTGTTTCTATATTGTTTTCAATCATTGGTGTATTAGTAATACTAAGTGGTCTTATTACTTTAAAAGTGAAATAG", "fmax": "1660922", "accession": "CP065927.1", "fmin": "1659728", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus pyogenes", "NCBI_taxonomy_id": "1314", "NCBI_taxonomy_cvterm_id": "36764"}, "protein_sequence": {"accession": "QQA64076.1", "sequence": "MENNKWKQKFFAIYTGQFFSLLSSAAVQFGIIWWLTDKTGGSPLLLTLAGLAGFLPQALVGPFAGTITDRYSRKFLMISADMTVALGSLILFLILHFYEANIIFVILILALRSLATAFHMPAMQASIPLLAPEEALTKVAGWGQMVASVSNIVGPAVGMSILSVSSIKWVLLLDILGAVVASGILLFINIPKIQKTESVELTSFFVEMKEGYNALVNHPILLKLTILMTIVAVLYIPLGTYFPLMTRNHFGKGVVEAGTVEIAFAIGLIVGGSLLGIIGDKFEKVKTMAIGMLLMGLALFFSGLLSPSLFFIFIILSGLVGFSGPLFSAPFYAYIQTEIEPQLLGRIFSFVTSLSLLATPIGYALSGLLIEFTSVSILFSIIGVLVILSGLITLKVK"}}}}, "model_name": "mefJ", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "mefJ", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "mefJ", "ARO_id": "45608", "model_type_id": "40292"}, "5749": {"model_id": "5749", "ARO_accession": "3007050", "model_param": {"blastp_bit_score": {"param_value": "450", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "mreA is a macrolide efflux pump.", "model_sequences": {"sequence": {"8303": {"dna_sequence": {"partial": "0", "sequence": "ATCATGAAAATCCATTACATTAATGATTATAAAGATATTCAAGCTAAAGAAGATTGCGTCTTAGTTTTGGGCTATTTTGATGGCTTACATCTGGGACATAAAGCCCTCTTTGATAAAGCTAAAAAAATCGCGACCGAAAAAAATTTGAAAATTGTCGTCTTAACGTTTAATGAGACACCTCGTCTAACCTTCGCTCGCTTCCAACCTGAATTATTGCTACATCTTACCTCTCCAGAAAAACGTTCTGAAAAATTTCAAGAGTATGGCGTCGATGAGTTATATTTAATGAATTTTACCAGTCATTTTTCAAAAGTATCTTCTGACCTTTTTATTAAGAAATATATTTATGGTCTCAGAGCAAAAGCTGCTGTTGTCGGTTTTGATTATAAGTTCGGTCATAATCGTACCAGTGGTGATTATCTAGCGCGTAATTTCAAGGGACCAGTCTATATTATTGATGAAATTTCTGAAGGTGGTGAAAAAATCTCTTCTACACGTATTCGTCAATTGATTACAGAGGGTAATGTTGAGAAAGCTAACCAACTTTTGGGTTATGAGTTTTCAACCTGTGGCATGGTAGTACATGGAGATGCTAGAGGACGAACTATAGGGTTCCCAACTGCTAATCTAGCTCCTATTAATCGCACTTACTTACCTGCAGACGGTGTTTATATTTCCAATGTTCTGATTAATGGAAAATATTATAGAGCAATGACGAGCATTGGAAAAAATATCACTTTTGGTGGTACAGAACTTCGTTTAGAAGCTAATATCTTTGATTTTGATGGCGACATTTATGGAGAAACTATTGAAATTTTCTGGTTAAAAAGAATCAGAGAAATGGTAAAGTTTAATGGTATTGACGATCTTGTAAAACAACTTAAAAAAGATAAAGAAATTGCTTTAAATTGGAAAAAAGATAGTCAAACTCTTTAA", "fmax": "1054", "accession": "U92073.1", "fmin": "118", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus agalactiae", "NCBI_taxonomy_id": "1311", "NCBI_taxonomy_cvterm_id": "36847"}, "protein_sequence": {"accession": "AAB64408.1", "sequence": "MMKIHYINDYKDIQAKEDCVLVLGYFDGLHLGHKALFDKAKKIATEKNLKIVVLTFNETPRLTFARFQPELLLHLTSPEKRSEKFQEYGVDELYLMNFTSHFSKVSSDLFIKKYIYGLRAKAAVVGFDYKFGHNRTSGDYLARNFKGPVYIIDEISEGGEKISSTRIRQLITEGNVEKANQLLGYEFSTCGMVVHGDARGRTIGFPTANLAPINRTYLPADGVYISNVLINGKYYRAMTSIGKNITFGGTELRLEANIFDFDGDIYGETIEIFWLKRIREMVKFNGIDDLVKQLKKDKEIALNWKKDSQTL"}}}}, "model_name": "mreA", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "mreA", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "mreA", "ARO_id": "45609", "model_type_id": "40292"}, "5762": {"model_id": "5762", "ARO_accession": "3007032", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "Erm(50) is an Erm ribosomal RNA methyltransferase.", "model_sequences": {"sequence": {"8322": {"dna_sequence": {"partial": "0", "sequence": "ATGCCTACCTACAGGCCGAACAAGGGCCGTCACGAGAACGGCCAGAACTACCTCGTCAATGAGGCGACGATCAGACGGATCGTCGACCTCGTCCCCGTCAACGCCTCCGTCCCGGTCATCGAGATCGGCCCGGGACACGGGGCGCTGACCTTTCCCCTTCAGGATCGTGTCTTGGCTGCCGGTGGATCGTTGACCGCCGTCGAGATCGACCCGGCCTCTGTCCGGTGGTTGGAGAAGCGGCTGCGCCCGGAGGTCCACCTGTACGAGCAGGATGTCCTTGATTTTGTGCTTCCGGACGGCCCGCACGTCCTGGTGGGGAACCTGCCGTTCCACCTGACCACCGCGATCCTGCGGCACGTCCTTCACTCACCGGGGTGGACCCACGCGGTGCTCCTGGTGCAGTGGGAGGTCGCGCGCCGCCGCGCCGGTGTCGGTGGTGCCACGATGATGACTGCCCAGTGGTGGCCGTGGGTCGACTTCGAACAGTACGGGCGGGTGCCGTCCACGCATTTCCGTCCCCGCCCCACCGTCGACGCCGGTGTCCTGGTGATACGTCGCCGGGAGGAACCTCTCGTGGACTGGTCGGAGCGTGCGCGGTACGCGTCCTTCGTCCATGACGTGTTCACCGGCAAGGGCCGTGGCGTCGCCGACATCGTGTCCCGGGTTGTGGGGCGTCGGCGTGCGCGACGGTGTGCCCAGGTCTTGCGTGAGGCCGGTGTTCCGGCACACGCACTGCCGAAACAGTTGGACGCGGGGCAGTGGGCCACACTGTTTACGGCCGTGGGGTGCTAA", "fmax": "20848", "accession": "LC473083.1", "fmin": "20056", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Cutibacterium acnes", "NCBI_taxonomy_id": "1747", "NCBI_taxonomy_cvterm_id": "40344"}, "protein_sequence": {"accession": "BBJ25230.1", "sequence": "MPTYRPNKGRHENGQNYLVNEATIRRIVDLVPVNASVPVIEIGPGHGALTFPLQDRVLAAGGSLTAVEIDPASVRWLEKRLRPEVHLYEQDVLDFVLPDGPHVLVGNLPFHLTTAILRHVLHSPGWTHAVLLVQWEVARRRAGVGGATMMTAQWWPWVDFEQYGRVPSTHFRPRPTVDAGVLVIRRREEPLVDWSERARYASFVHDVFTGKGRGVADIVSRVVGRRRARRCAQVLREAGVPAHALPKQLDAGQWATLFTAVGC"}}}}, "model_name": "Erm(50)", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36699": {"category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_cvterm_id": "36699", "category_aro_accession": "3000560", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "Erm(50)", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "Erm(50)", "ARO_id": "45591", "model_type_id": "40292"}, "5763": {"model_id": "5763", "ARO_accession": "3004956", "model_param": {"blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}, "snp": {"param_type": "single resistance variant", "param_value": {"12558": "G70D"}, "clinical": {"12558": "G70D"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}}, "ARO_description": "rpld encodes for the 50S L4 ribosomal protein, is a macrolide resistance protein identified in Neisseria gonorrhoeae.", "model_sequences": {"sequence": {"8334": {"dna_sequence": {"partial": "0", "sequence": "ATGGAATTGAAAGTAATTGACGCTAAAGGACAAGTTTCAGGCAGCCTGTCTGTTTCTGATGCTTTGTTCGCCCGCGAATACAATGAAGCGTTGGTTCACCAGCTGGTAAATGCCTACTTGGCAAACGCCCGCTCTGGTAACCGTGCTCAAAAAACCCGTGCCGAAGTAAAACACTCAACCAAAAAACCATGGCGTCAAAAAGGTACCGGCCGCGCCCGTTCCGGTATGACTTCTTCTCCGCTGTGGCGTAAAGGCGGTCGCGCGTTCCCGAACAAACCCGACGAAAACTTCACTCAAAAAGTAAACCGTAAAATGTACCGTGCCGGTATGGCGACTATCCTGTCCCAATTGGCGCGTGACGAGCGTTTGTTTGTGATTGAGGCGTTGACTGCCGAAACTCCCAAAACCAAAGTTTTTGCCGAACAAGTAAAAAATTTGGCTCTGGAGCAAGTGCTGTTTGTAACCAAACGGCTCGACGAGAATGTTTACTTGGCTTCACGCAACTTGCCAAACGTATTGGTTTTGGAAGCTCAACAAGTTGATCCTTACAGCTTGCTGCGTTATAAAAAAGTAATCATCACTAAAGATGCGGTTGCACAATTAGAGGAGCAATGGGTATGA", "fmax": "1805929", "accession": "AE004969.1", "fmin": "1805308", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae", "NCBI_taxonomy_id": "485", "NCBI_taxonomy_cvterm_id": "36806"}, "protein_sequence": {"accession": "WP_003690088.1", "sequence": "MELKVIDAKGQVSGSLSVSDALFAREYNEALVHQLVNAYLANARSGNRAQKTRAEVKHSTKKPWRQKGTGRARSGMTSSPLWRKGGRAFPNKPDENFTQKVNRKMYRAGMATILSQLARDERLFVIEALTAETPKTKVFAEQVKNLALEQVLFVTKRLDENVYLASRNLPNVLVLEAQQVDPYSLLRYKKVIITKDAVAQLEEQWV"}}}}, "model_name": "Neisseria gonorrhoeae rpld", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "43188": {"category_aro_name": "50S rRNA with mutation conferring resistance to macrolide antibiotics", "category_aro_cvterm_id": "43188", "category_aro_accession": "3005001", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Nucleotide point mutations in the 50S rRNA subunit (not in the 23s rRNA range) may confer resistance to macrolide antibiotics."}, "36297": {"category_aro_name": "azithromycin", "category_aro_cvterm_id": "36297", "category_aro_accession": "3000158", "category_aro_class_name": "Antibiotic", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}}, "ARO_name": "Neisseria gonorrhoeae rpld", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "CARD_short_name": "Ngon_rpld", "ARO_id": "43142", "model_type_id": "40293"}, "5760": {"model_id": "5760", "ARO_accession": "3007061", "model_param": {"blastp_bit_score": {"param_value": "720", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "Hp1165 is a homolog of the clostridium perfringes tetP gene and is part of the MFS efflux family. It contributes to tetracycline resistance in Helicobacter pylori.", "model_sequences": {"sequence": {"8319": {"dna_sequence": {"partial": "0", "sequence": "ATGTTAAGGAAAAACATTTTAGCTTACTATGGGGCGAATTTTCTCTTAATCATCGCTCAAAGCTTACCCCATGCGATTTTAACCCCCTTGTTGCTTTCTAAAGGGCTTAGTTTGAGTGAAATCTTGCTCGTGCAAACCTTTTTTAGCTTTTGCGTGCTAGTGGCTGAATACCCAAGCGGCGTTTTAGCGGATTTGATGAGCCGAAAAAATTTATTCCTGGTTTCTAATGCCTTTTTAATCGCTAGTTTTTCGTTTGTGCTGTTTTTTGATAGCTTTATTTTCATGCTTTTAGCGTGGGGGTTGTATGGTTTGTATAGCGCATGCTCTAGCGGCACGATTGAAGCTTCACTCATCACAGACATTAAGGAAAACAAAAAAGATTTATCCAAGTTTTTAGCCAAAAACAATCAAATTACTTATTTAGGCATGATTATAGGGAGTTCTTTGGGATCGTTTTTGTATCTCAAAGTCCATGCGATGCTGTATATTGTGGGGATTTTTTTAATCATGCTCTGTGTGCTAACGATCATTTTTTATTTTAAAGAGAAAGAAGGGGATTTTAAAAGCCAAAAAAGCCTGAAACTCCTTAAAGAGCAAGTCAAAGGCAGTCTTAAAGAGCTTAAAGATAACCCCAAACTTAAAATTCTGTTAGTGGGGCATTTGATTACGCCCGTCTTTTTTATGAGCCATTTTCAAATGTGGCAAGCGTATTTTTTAAAACAAGGCGTTAAAGAGCAATACCTTTTTGTGTTTTATATCGCTTTTCAAGTGATTTCTATTCTCATTCATTTTTTAAAAGCCTCTAGTTATAGCCAAAAAATCGCCTTGAGTTCGCTTGTGGTGTTGTTAGGCGTTAGCCCCTTATTGCTTAGCAATATCCCTTATTGTTTCATAGGGGTGTATGCGCTCATGGTGGCGTTTTTCACTTACATGAGCTATTGCTTAAACTATCAATTCTCCAAATTCGTTTCTAAAAACAACATTTCCTCGCTCTCATCGCTTTTATCAAGCTGTGTGCGCGTGGTCTCTGTGCTAATCTTATCGCTCAGCAGTCTGGAACTGCGTTACTTCTCACCCCTAACTATCATAACCATGCATTTTGCCTTGACGCTTATCATCCTCTTTTTCTTTTTGTATAAGGCTAAGCCGTTTGATGAGTGA", "fmax": "1230596", "accession": "NC_000915.1", "fmin": "1229435", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori", "NCBI_taxonomy_id": "210", "NCBI_taxonomy_cvterm_id": "36906"}, "protein_sequence": {"accession": "WP_000944753.1", "sequence": "MLRKNILAYYGANFLLIIAQSLPHAILTPLLLSKGLSLSEILLVQTFFSFCVLVAEYPSGVLADLMSRKNLFLVSNAFLIASFSFVLFFDSFIFMLLAWGLYGLYSACSSGTIEASLITDIKENKKDLSKFLAKNNQITYLGMIIGSSLGSFLYLKVHAMLYIVGIFLIMLCVLTIIFYFKEKEGDFKSQKSLKLLKEQVKGSLKELKDNPKLKILLVGHLITPVFFMSHFQMWQAYFLKQGVKEQYLFVFYIAFQVISILIHFLKASSYSQKIALSSLVVLLGVSPLLLSNIPYCFIGVYALMVAFFTYMSYCLNYQFSKFVSKNNISSLSSLLSSCVRVVSVLILSLSSLELRYFSPLTIITMHFALTLIILFFFLYKAKPFDE"}}}}, "model_name": "hp1165", "ARO_category": {"36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "35968": {"category_aro_name": "tetracycline", "category_aro_cvterm_id": "35968", "category_aro_accession": "0000051", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "hp1165", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "hp1165", "ARO_id": "45622", "model_type_id": "40292"}, "5761": {"model_id": "5761", "ARO_accession": "3007062", "model_param": {"blastp_bit_score": {"param_value": "425", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "VAM-1 is a subclass B1 metallo-beta-lactamase, conferring resistance to beta-lactam antibiotics such as carbapenems and cephalosporins.", "model_sequences": {"sequence": {"8320": {"dna_sequence": {"partial": "0", "sequence": "ATGAATTTTCTGATAAAAAATATTCTGCTCATTACTCTTTTTGTTCCTTTTGTAACAGCAGCAAACAATACAGACACTAAAACGCTGGAGGTTAAACAATTAACCGATAATATCTATCAGCATATCTCATATAAACATGTTGAGCCTTGGGGGTTTATTGGCGCGTCTGGCTTAATTGTAGTCGATGGAGATGCGGCATACCTGATTGACACTCCTTGGACGACCAAAGCAACCAATCAACTTATTGAATGGATTGAAGATAGAGGTCTCGTACTAAAAAGCGCAATAGTAACTCACTTTCATGAAGATGCGAGTGGTGATTTACCACTTTTAAATGATTTAAAAGTTAACACTTATGCCACTTCACTCACTAATCAACTTCTTAAACTCAATAACAAAGAAATTTCGAATACTGAAATATCGAGCAATGAACTCAAAATTTTCAACGGCATTGCGACAGTGTATTATCCTGGCCCAGGCCATACTGAAGATAACATCGTTGTTTGGTTACCGAATGAAAAGCTATTATTTGGCGGTTGCTTTGTTAAAAGCCTCCGTAATAAAAGTCTAGGTTACACTGGAGATGCAAATATAGGCGAATGGTCGAACTCTATTCAAAGAGTGCTGCAACGCTATCCAGATATAGTCACTGTAGTGCCTGGGCATGGTCAGGTTGGAGACGTTAGTTTACTCCTTCATACACAAAAATTAGCATCATCCGATAAGACTTCTGACAAATAG", "fmax": "741", "accession": "MW827739.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Vibrio alginolyticus", "NCBI_taxonomy_id": "663", "NCBI_taxonomy_cvterm_id": "43205"}, "protein_sequence": {"accession": "QTJ60982.1", "sequence": "MNFLIKNILLITLFVPFVTAANNTDTKTLEVKQLTDNIYQHISYKHVEPWGFIGASGLIVVDGDAAYLIDTPWTTKATNQLIEWIEDRGLVLKSAIVTHFHEDASGDLPLLNDLKVNTYATSLTNQLLKLNNKEISNTEISSNELKIFNGIATVYYPGPGHTEDNIVVWLPNEKLLFGGCFVKSLRNKSLGYTGDANIGEWSNSIQRVLQRYPDIVTVVPGHGQVGDVSLLLHTQKLASSDKTSDK"}}}}, "model_name": "VAM-1", "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "36989": {"category_aro_name": "cefotaxime", "category_aro_cvterm_id": "36989", "category_aro_accession": "3000645", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups."}, "45626": {"category_aro_name": "VAM beta-lactamase", "category_aro_cvterm_id": "45626", "category_aro_accession": "3007065", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "VAM beta-lactamases are class B1 beta-lactamases found in Vibrio alginolyticus."}, "35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36981": {"category_aro_name": "ampicillin", "category_aro_cvterm_id": "36981", "category_aro_accession": "3000637", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "35968": {"category_aro_name": "tetracycline", "category_aro_cvterm_id": "35968", "category_aro_accession": "0000051", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome."}, "35996": {"category_aro_name": "clavulanic acid", "category_aro_cvterm_id": "35996", "category_aro_accession": "0000079", "category_aro_class_name": "Adjuvant", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "35981": {"category_aro_name": "amoxicillin", "category_aro_cvterm_id": "35981", "category_aro_accession": "0000064", "category_aro_class_name": "Antibiotic", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan."}, "35979": {"category_aro_name": "ceftriaxone", "category_aro_cvterm_id": "35979", "category_aro_accession": "0000062", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria."}, "40924": {"category_aro_name": "amoxicillin-clavulanic acid", "category_aro_cvterm_id": "40924", "category_aro_accession": "3003997", "category_aro_class_name": "Antibiotic", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate)."}}, "ARO_name": "VAM-1", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "VAM-1", "ARO_id": "45623", "model_type_id": "40292"}, "3453": {"model_id": "3453", "ARO_accession": "3001744", "model_param": {"blastp_bit_score": {"param_value": "530", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "OXA-289 is a beta-lactamase found in Acinetobacter spp.", "model_sequences": {"sequence": {"8311": {"dna_sequence": {"partial": "0", "sequence": "ATGCCAAAAATACTAAAACATCTTAGCCTTTGCGCATCTGTAATGATTGGACTGACCTTGCTTGGTTGTCAAAATTTTCACGCCCCAACTCAAAGCGCCGTGTCAAAAAAACACGATCAAACCGAGATCGCTTCTTTATTCCAACATGCTCAAACTGTTGGCGTATTTGTTACATATGATGGGCAAACACTTCAAGCATATGGCAATGCGTTGAGTCGATCGAATACGGCTTATATTCCAGCCTCAACCTTCAAGATGTTAAATGCTCTGATTGGGATACAGCATCACAAAACTTCACCAAACGAAGTGTTTAAATGGGATGGCAAAAAGCGTGCTTTTGCGAGCTGGGAAAAAGATTTAACTTTAGCCGAGGCGATGCAGGCATCAGCAGTGCCTGTTTATCAGGAATTGGCTCGGCGTATCGGGTTAGAGTTGATGGCGAACGAAGTAAAACGCGTTGGCTTTGGCAATGCCGAGATCGGAACGCAAGTCGATGATTTTTGGTTGGTTGGCCCGCTTAAGATTACCCCAATTGAAGAGGTTAAATTTGCTTATGCTTTGGCAAATAAGCAGCTTGAATTTGACCAATCTGTGCAAAAACAAGTGAAACAGATGGTCTTCGTTGATGAAGTTCATGGAACTAAGATTTATGCCAAAAGTGGTTGGGGGATGGATGTAACACCGCAAGTGGGTTGGTGGACGGGCTGGATTGAACAACCGAATGGACAGGTGATTGCATTTTCTTTAAATCTGGAAATAAATAAGCCTGAGCACGGTGATGCGCGTAAAGCGATTGTTTATCAAGCATTACAACAATTGAAATTGTTACAGAAGCAATAA", "fmax": "283403", "accession": "APRM01000005.1", "fmin": "282563", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter sp. NIPH 298", "NCBI_taxonomy_id": "1217692", "NCBI_taxonomy_cvterm_id": "45611"}, "protein_sequence": {"accession": "WP_081400730.1", "sequence": "MPKILKHLSLCASVMIGLTLLGCQNFHAPTQSAVSKKHDQTEIASLFQHAQTVGVFVTYDGQTLQAYGNALSRSNTAYIPASTFKMLNALIGIQHHKTSPNEVFKWDGKKRAFASWEKDLTLAEAMQASAVPVYQELARRIGLELMANEVKRVGFGNAEIGTQVDDFWLVGPLKITPIEEVKFAYALANKQLEFDQSVQKQVKQMVFVDEVHGTKIYAKSGWGMDVTPQVGWWTGWIEQPNGQVIAFSLNLEINKPEHGDARKAIVYQALQQLKLLQKQ"}}}}, "model_name": "OXA-289", "ARO_category": {"35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "36026": {"category_aro_name": "OXA beta-lactamase", "category_aro_cvterm_id": "36026", "category_aro_accession": "3000017", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime."}}, "ARO_name": "OXA-289", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "OXA-289", "ARO_id": "38144", "model_type_id": "40292"}, "5728": {"model_id": "5728", "ARO_accession": "3007012", "model_param": {"blastp_bit_score": {"param_value": "100", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes.", "model_sequences": {"sequence": {"8124": {"dna_sequence": {"partial": "0", "sequence": "ATGATTGTGAACTTTTTCAAGCATAAATTTTATAATTTATTAACTACAATGATTGTTCTCTTTGTGTTTGTGTTGTCCGGTGCAATTTTTTTAACATTTCTAGGTTTTGGACTTTATGGTCTTAGCAGGATACTTATATACTTTAGGTTAGGTGATTTCACGTATAATAGAAATATGTATGATAATTTATTGTATTACGGTAGTTATATCATATTTGGTTATTTTATCATTTTTGCAGTCGAACATTTAATGGATTATTTTAGAAAGATGCTTCCTGAAAATGCATATTTTAGAGGAGCAACATTCCATTTAATATCTTATACGGTTGCTACTACATTATTTTATTTCATTATTCATTTACATTATGTGTATATTAATATTGATTTTTGGGTCATCATGGTAATCATAGGCTTTCTTTATGTATGTAAACTTCAATTTTACCCTGAAAGTAAAAATCTCAATAATAGAAAATAA", "fmax": "2187613", "accession": "NC_016941.1", "fmin": "2187139", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus", "NCBI_taxonomy_id": "1279", "NCBI_taxonomy_cvterm_id": "37074"}, "protein_sequence": {"accession": "WP_042355600.1", "sequence": "MIVNFFKHKFYNLLTTMIVLFVFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRNMYDNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHLHYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK"}}}}, "model_name": "sepA", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36004": {"category_aro_name": "small multidrug resistance (SMR) antibiotic efflux pump", "category_aro_cvterm_id": "36004", "category_aro_accession": "0010003", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "sepA", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "sepA", "ARO_id": "45481", "model_type_id": "40292"}, "5729": {"model_id": "5729", "ARO_accession": "3007013", "model_param": {"blastp_bit_score": {"param_value": "200", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene.", "model_sequences": {"sequence": {"8125": {"dna_sequence": {"partial": "0", "sequence": "ATGCGATTAAAGTCAATCATAACTGTTATAGCTTTAATATTAATTATGTTTATGTCAGCGATTGAATCATCTATTATTTCGCTTGCATTACCTACAATTAAACAAGATTTAAATGCAGGAAATTTAATTTCATTAATTTTTACAGCGTATTTTATCGCATTAGTAATTGCCAATCCTATAGTGGGAGAATTACTTTCGAGATTTAAAATTATTTATGTGGCAATTGCAGGATTACTTTTATTTAGTATAGGTAGTTTTATGTGTGGTTTAAGTACTAATTTTACTATGCTAATTATATCACGCGTGATACAAGGTTTTGGATCAGGTGTATTGATGTCATTATCGCAAATTGTTCCAAAGTTAGCATTTGAAATTCCGTTACGATATAAAATTATGGGCATAGTTGGCAGTGTTTGGGGTATTTCGAGTATCATTGGACCGCTTCTAGGTGGTGGTATATTAGAATTTGCAACATGGCATTGGTTATTCTACATAAATATACCGATTGCGATCATTGCCATTATATTAGTTATATGGACATTTCATTTTCCAGAGGAAGAAACAGTTGCTAAATCAAAATTTGATACTAAAGGGCTCACGCTATTTTATGTATTTATTGGATTGATTATGTTTGCTTTATTAAACCAACAGCTATTACTTTTAAATTTCTTGAGTTTTATCTTAGCTATCGTTGTGGCAATGTGTTTATTTAAAGTAGAAAAACATGTTTCTTCACCATTTTTACCTGTGGTTGAATTTAATCGTTCGATTACTTTAGTTTTTATAACGGACCTTCTAACAGCTATTTGTTTAATGGGATTCAATTTATATATTCCAGTCTACCTTCAAGAACAACTAGGATTATCTCCATTGCAAAGTGGATTGGTTATTTTTCCTTTATCTGTAGCTTGGATTACATTGAATTTTAATTTACATCGAATTGAAGCAAAACTATCAAGGAAAGTTATTTACTTACTATCATTTACATTGTTACTAGTAAGTAGTATTATCATTTCATTTGGTATTAAATTGCCGGTACTTATAGCATTTGTGTTAATTTTGGCAGGATTAAGTTTTGGATATATTTATACGAAAGATAGTGTAATTGTCCAAGAGGAAACTAGCCCATTACAAATGAAGAAAATGATGTCATTTTATGGATTAACTAAAAATCTTGGGGCATCAATAGGTTCAACAATAATGGGATATCTTTATGCGATACAATCAGGAATCTTTGGTCCAAACTTACACAATGTGTTAAGTGCTGTTGCTGTAATTAGCATTGGGCTTATTGTTTTATGGGTCGTATTTTTTAAAGAACAGTCATCTCAATCAAAAGAATAG", "fmax": "2241223", "accession": "BA000018.3", "fmin": "2239879", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus subsp. aureus N315", "NCBI_taxonomy_id": "158879", "NCBI_taxonomy_cvterm_id": "35514"}, "protein_sequence": {"accession": "BAB43261.1", "sequence": "MRLKSIITVIALILIMFMSAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLSRFKIIYVAIAGLLLFSIGSFMCGLSTNFTMLIISRVIQGFGSGVLMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVIWTFHFPEEETVAKSKFDTKGLTLFYVFIGLIMFALLNQQLLLLNFLSFILAIVVAMCLFKVEKHVSSPFLPVVEFNRSITLVFITDLLTAICLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHRIEAKLSRKVIYLLSFTLLLVSSIIISFGIKLPVLIAFVLILAGLSFGYIYTKDSVIVQEETSPLQMKKMMSFYGLTKNLGASIGSTIMGYLYAIQSGIFGPNLHNVLSAVAVISIGLIVLWVVFFKEQSSQSKE"}}}}, "model_name": "sdrM", "ARO_category": {"36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "37006": {"category_aro_name": "norfloxacin", "category_aro_cvterm_id": "37006", "category_aro_accession": "3000662", "category_aro_class_name": "Antibiotic", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes."}, "36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}, "ARO_name": "sdrM", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "sdrM", "ARO_id": "45482", "model_type_id": "40292"}, "5726": {"model_id": "5726", "ARO_accession": "3007010", "model_param": {"blastp_bit_score": {"param_value": "525", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.", "model_sequences": {"sequence": {"8122": {"dna_sequence": {"partial": "0", "sequence": "ATGAATGAAACGTATCGCGGGGGCAACAAGTTAATCTTAGGTATTGTATTAGGTGTTATTACATTTTGGTTGTTTGCACAATCACTTGTAAATGTTGTGCCAAATTTACAACAAAGTTTTGGTGCAGACATGGGAACAATTAGTATTGCGGTAAGTCTAACCGCACTATTTTCAGGCATGTTTGTTGTTGGAGCAGGCGGCCTAGCAGATAAAATTGGACGCGTGAAAATGACAAATATCGGCTTATTATTAAGTATTATTGGTTCAGCATTAATTATTATTACAAATTTACCAGCATTGCTAATTTTAGGCCGTATTATACAAGGCGTATCAGCAGCGTGTATTATGCCTTCCACATTGGCCATTATGAAAACTTATTATGAGGGTGCTGAACGTCAGCGTGCCTTAAGCTATTGGTCTATCGGTTCTTGGGGTGGAAGTGGTATCTGTTCACTCTTCGGTGGGGCAGTTGCGACAACTATGGGTTGGAGATGGATTTTCATCTTCTCAATCATCGTTGCCGTACTTTCAATGTTACTCATCAAAGGGACGCCTGAAACGAAATCAGAAGTTACCAATACACATAAATTTGACGTTGCAGGTCTAATTGTTCTAGTAGTTATGTTATTAAGTTTAAACGTTGTCATTACTAAAGGTGCAGCACTTGGTTATACATCATTATGGTTCTTTGGTTTGATTGCAATCGTAATTGTAGCATTCTTTATTTTCTTAAATGTTGAGAAAAAAGTAGATAATCCGCTTATTGATTTTAAATTATTTGAAAATAAACCATATACAGGTGCAACGATTTCGAACTTCTTATTAAACGGTGTTGCAGGTACATTAATTGTAGCGAATACATTCGTACAACAAGGTTTAGGTTATACAGCATTGCAGGCAGGATACTTATCAATCACTTATTTAATCATGGTGTTATTGATGATTAGAGTTGGTGAAAAATTATTACAAAAAATGGGTTCTAAGCGACCAATGTTATTAGGTACATTCATTGTGATCATTGGTATTGCACTTATTTCATTAGTATTCTTACCAGGCATATTTTATGTTATCAGTTGTGTCGTAGGATATTTATGTTTTGGACTAGGCTTAGGTATTTATGCAACACCTTCTACAGATACAGCTATTTCAAATGCACCGTTAGATAAAGTTGGCGTTGCTTCAGGTATTTATAAAATGGCTTCATCACTTGGTGGTGCATTCGGTGTCGCAATTAGTGGTGCAGTATATGCCGGTGCAGTTGCTGCAACGAGCATTCATACAGGTGCGATGATTGCACTTTGGGTTAACGTATTAATGGGAATCATGGCATTTATCGCAATTTTATTTGCGATTCCTAATGATGATAAACGTGTCAAAGATGCGAAATAA", "fmax": "118335", "accession": "CP005288.1", "fmin": "116946", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"accession": "AGP27106.1", "sequence": "MNETYRGGNKLILGIVLGVITFWLFAQSLVNVVPNLQQSFGADMGTISIAVSLTALFSGMFVVGAGGLADKIGRVKMTNIGLLLSIIGSALIIITNLPALLILGRIIQGVSAACIMPSTLAIMKTYYEGAERQRALSYWSIGSWGGSGICSLFGGAVATTMGWRWIFIFSIIVAVLSMLLIKGTPETKSEVTNTHKFDVAGLIVLVVMLLSLNVVITKGAALGYTSLWFFGLIAIVIVAFFIFLNVEKKVDNPLIDFKLFENKPYTGATISNFLLNGVAGTLIVANTFVQQGLGYTALQAGYLSITYLIMVLLMIRVGEKLLQKMGSKRPMLLGTFIVIIGIALISLVFLPGIFYVISCVVGYLCFGLGLGIYATPSTDTAISNAPLDKVGVASGIYKMASSLGGAFGVAISGAVYAGAVAATSIHTGAMIALWVNVLMGIMAFIAILFAIPNDDKRVKDAK"}}}}, "model_name": "norC", "ARO_category": {"36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "37006": {"category_aro_name": "norfloxacin", "category_aro_cvterm_id": "37006", "category_aro_accession": "3000662", "category_aro_class_name": "Antibiotic", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes."}, "36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "35963": {"category_aro_name": "acriflavine", "category_aro_cvterm_id": "35963", "category_aro_accession": "0000045", "category_aro_class_name": "Antibiotic", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish."}, "35954": {"category_aro_name": "ciprofloxacin", "category_aro_cvterm_id": "35954", "category_aro_accession": "0000036", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}}, "ARO_name": "norC", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "norC", "ARO_id": "45478", "model_type_id": "40292"}, "5727": {"model_id": "5727", "ARO_accession": "3007011", "model_param": {"blastp_bit_score": {"param_value": "200", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "mdeA is a multidrug efflux pump that confers resistance  in varying degrees to several unrelated antibiotics, including kanamycin, tetracycline, ampicillin, oxacillin, ciprofloxacin, nalidixic acid, acriflavine, and ethidium bromide.", "model_sequences": {"sequence": {"8123": {"dna_sequence": {"partial": "0", "sequence": "ATGACGAAACATTTACAAGATTTTTTAATAACAGTTATCGCAGGTATGGGAATGTTATTATCCACCCTTGATACAGGTATTATCAATGTTGCATTATCCTTTTTGAGGGGACAATTTCAAACCACAACTAACATTGCCTCTTTTACAATAACTGGATATACTTTAGCATTAGCTATCTCTATCTTACCTTTAGGAGTATTAAGCGATAAATTTGGAAAGTTAAAGATTTCCTACTTAGGATTTGTACTTTTTGGACTGAGCTCCTTATTTTGTGGATTTGCTAATAGTATTGGCTGGCTCATTACTGGCCGGATTATTCAAGGAATGGGAGCGGCGGCTTTGCAAGCTACTTCAGCAGCTCTGATTACCACTTTAGTTTCCGAAGACCGCAAAAACAGTGCTATTAGTATTTTAGGAGTTATGATTGGCTTAGGACCTGTCCTCGGTCCTTCCTTAGGAGGCATACTACTTTCTTTAAATCTCTGGCGCTTTATTTTCTGGATTAATGTTCCCTTTGCTCTTATTGTCATCATTTGTAATCACTATCTCCTTACTAAAGTCTCCGAACAAACTAGTGAGTGGACATTAGATTCTCTTGGAACAGTTCTCAATGCTTCTATGTTGGTTTGTCTTCTCTTAGGACTATCCTTACTCAGTAAGCCTCACCTATTAGGTATCAGTCTTATTTTGATCATCATTAGTTTCTTGATCGGGATTTGGTTTTACCGTCTTGAATGCAGCAAAGAGAGTGCTCTTGTCAATGTCAAGGGGCTGAGCGAGAATCCTCGAGTACTTTCTTATCTTTTTCAAACGGTCGCTTTTGGTTTTGCCTCTGCAATGATATTCTTACTTCCACCCTTCATTTTTGAACAATTATATCATTTAGGAGTGGGGCAGACAGGCTTTCTTGTACTAGGAGCACCTGCAGGCCTGGTTCTTTTTTCAAGAATATCTGGTAAAATCAATGATGGCAGTAAAAATAAATCATTTAGCCATATTGGTTTGGGTATCATTATTTTATCCTTAATTTTCCTCCTACTTCTCACGCCTAGCTGGCCCTATTTATTCTTAACTTTAGGATTATTTATTTATGGTATTGGCGGAGGATACTTTCAGCCTGCTAATATGGCTAGTATTATGCTAGCTAGTCCTATGAAAATGCAAGGTAGCACAGGAGCATTGCAACGAATGGTACAAAACATTGCTATTTCAGCTGGTTCAGCCATTGGATCAACTTGCTTAAACCTTTGGTCAAATAATCTATTATTGGCTACCCGAATTGGCTGGGGAATTACACTCGTTCTAGTTATTCTCAGTTTAAAAGAACTAACACCATTTAAAATGACTAATAAAACAGAATAA", "fmax": "1357304", "accession": "NZ_CP044221.1", "fmin": "1355942", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Streptococcus mutans", "NCBI_taxonomy_id": "1309", "NCBI_taxonomy_cvterm_id": "45480"}, "protein_sequence": {"accession": "WP_002289367.1", "sequence": "MTKHLQDFLITVIAGMGMLLSTLDTGIINVALSFLRGQFQTTTNIASFTITGYTLALAISILPLGVLSDKFGKLKISYLGFVLFGLSSLFCGFANSIGWLITGRIIQGMGAAALQATSAALITTLVSEDRKNSAISILGVMIGLGPVLGPSLGGILLSLNLWRFIFWINVPFALIVIICNHYLLTKVSEQTSEWTLDSLGTVLNASMLVCLLLGLSLLSKPHLLGISLILIIISFLIGIWFYRLECSKESALVNVKGLSENPRVLSYLFQTVAFGFASAMIFLLPPFIFEQLYHLGVGQTGFLVLGAPAGLVLFSRISGKINDGSKNKSFSHIGLGIIILSLIFLLLLTPSWPYLFLTLGLFIYGIGGGYFQPANMASIMLASPMKMQGSTGALQRMVQNIAISAGSAIGSTCLNLWSNNLLLATRIGWGITLVLVILSLKELTPFKMTNKTE"}}}}, "model_name": "mdeA", "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "36981": {"category_aro_name": "ampicillin", "category_aro_cvterm_id": "36981", "category_aro_accession": "3000637", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin."}, "37005": {"category_aro_name": "nalidixic acid", "category_aro_cvterm_id": "37005", "category_aro_accession": "3000661", "category_aro_class_name": "Antibiotic", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments."}, "35966": {"category_aro_name": "kanamycin A", "category_aro_cvterm_id": "35966", "category_aro_accession": "0000049", "category_aro_class_name": "Antibiotic", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth."}, "36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "35963": {"category_aro_name": "acriflavine", "category_aro_cvterm_id": "35963", "category_aro_accession": "0000045", "category_aro_class_name": "Antibiotic", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish."}, "35973": {"category_aro_name": "oxacillin", "category_aro_cvterm_id": "35973", "category_aro_accession": "0000056", "category_aro_class_name": "Antibiotic", "category_aro_description": "Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis."}, "35954": {"category_aro_name": "ciprofloxacin", "category_aro_cvterm_id": "35954", "category_aro_accession": "0000036", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}, "35935": {"category_aro_name": "aminoglycoside antibiotic", "category_aro_cvterm_id": "35935", "category_aro_accession": "0000016", "category_aro_class_name": "Drug Class", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}, "35968": {"category_aro_name": "tetracycline", "category_aro_cvterm_id": "35968", "category_aro_accession": "0000051", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome."}}, "ARO_name": "mdeA", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "mdeA", "ARO_id": "45479", "model_type_id": "40292"}, "5753": {"model_id": "5753", "ARO_accession": "3007053", "model_param": {"40438": {"param_value": {"12372": "45612,D91G,V199I+ 45613,D481E", "12373": "45612,N87K+45613,F438S", "12374": "45612,N87K,V199A+45613,D481E,R484K", "12375": "45612,N87K,V199I+45613,D484K", "12376": "45612,D91N,V199I+45613,D481E,D484K", "12377": "45612,D91N+45613,D481E,D484K", "12379": "45612,D91N,A129T+45613,S479G", "12381": "45612,D91N+45613,R484K", "12380": "45612,A129T+45613,S479G", "12382": "45612,N87Y+45613,R484K"}, "param_type_id": "40438", "param_type": "co-dependent single resistance variant", "param_description": "A model parameter to describe mutations in multiple genes or proteins where resistance is co-dependent on each. For example, the G247S SNP in M. tuberculosis gyrA does not confer resistance to fluoroquinolones. However, when the D500N SNP is also present in gyrB, resistance is conferred. In this case, gyrA G247S is co-dependent on gyrB D500N to confer resistance. This parameter is noted on relevant models with the following notation: [cvterm-id-gene-1],[gene-1-SNP]+[cvterm-id-gene-2],[gene-2-SNP]+ ... +[cvterm-id-gene-n],[gene-n-SNP] e.g. 39879,G247S+40052,D500N. This parameter is not currently included in any detection algorithms."}, "blastp_bit_score": {"param_value": "1200", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}, "snp": {"param_type": "single resistance variant", "param_value": {"12378": "E463K"}, "clinical": {"12378": "E463K"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}}, "ARO_description": "Point mutations in Helicobacter pylori conferring resistance to fluoroquinolone antibiotics.", "model_sequences": {"sequence": {"8313": {"dna_sequence": {"partial": "0", "sequence": "ATGCAAAATTACCAGAGCCATAGTATTAAGGTTTTAAAAGGCTTAGAGGGGGTTAGGAAACGCCCTGGAATGTATATTGGTGATACCAATGTGGGTGGGTTGCACCACATGGTGTATGAAGTCGTGGATAACGCTGTAGATGAGAGCATGGCGGGTTTTTGCGATACGATTAATATCACTTTGACCGATGAGGGTTCATGCATCGTAGAAGATAACGGGCGAGGCATTCCTGTAGATATTCACCCCACGGAAAAAATCCCCGCTTGCACCGTGGTTTTAACGATTTTGCATGCGGGGGGCAAGTTTGATAACGATACTTATAAAGTTTCAGGCGGTTTGCATGGCGTGGGCGTTTCGGTTGTGAACGCTTTGAGCAAACGCTTGATTATGACCATTAAAAAAGAGGGTCAAATTTATCGCCAAGAGTTTGAAAAGGGTATTCCTACTAGCGAGCTTGAAATCATTGGCAAAACCAAAAGCGCTAAAGAAAGCGGCACGACTATTGAATTTTTCCCTGATGAAAGCGTGATGGAAGTCGTTGAATTTCAAGCGGGTATTTTACAAAAACGCTTTAAAGAAATGGCGTATCTTAACGATGGCTTAAAAATTTCTTTCAAAGAAGAAAAAACCCAACTGCAAGAGACTTATTTCTATGAAGACGGCTTGAAACAATTCGTTAAAGACAGCGCTAAAAAAGAATTGCTCACCCCCATTATTTCGTTTAAAAGCATGGATGAAGAAACGCGCACTTCTATAGAAGTCGCTCTAGCGTATGCTGATGATTATAATGAAAACACTTTAAGCTTTGTGAATAACATTAAAACTTCTGAAGGTGGCACGCATGAGGCGGGCTTTAAAATGGGCTTGTCTAAAGCAATTTTGCAATATATTGGCAATAATATTAAAACCAAAGAGTCACGCCCCATCTCTGAAGATATTAAAGAGGGGTTGATCGCTGTTGTGAGCTTGAAAATGAGCGAGCCTTTGTTTGAAGGGCAGACTAAATCCAAACTCGGCAGTTCGTATGCGCGCGCGTTGGTTTCAAAATTAGTCTATGATAAAATCCATCAATTTTTAGAAGAAAACCCTAACGAAGCCAAAATCATTGCCAATAAAGCCCTACTAGCTGCAAAAGCCAGAGAAGCCAGTAAGAAAGCCAGAGAGCTTACAAGGAAAAAAGATAATTTGAGTGTCGGCACTTTGCCTGGAAAATTAGCCGATTGCCAGAGTAAAGACCCCTTAGAGAGTGAAATCTTTTTAGTGGAGGGCGATAGTGCGGGCGGGAGCGCTAAACAAGGGCGCGATAGGGTTTTCCAAGCGATCTTGCCCCTAAAAGGTAAGATTTTAAATGTGGAAAAAAGCCATTTATCAAAAATCCTAAAATCAGAAGAAATTAAAAACATGATCACGGCTTTTGGGTGCGGCATTCAAGAGAGTTTTGATATAGAAAGATTGCGCTATCATAAAATCATTATCATGACCGATGCTGATGTGGATGGGAGCCATATCCAAACCTTGCTGATGACTTTTTTCTATCGTTATTTGCGCCCGCTGATTGAACAAGGGCATGTTTATATCGCTCAAGCCCCTCTTTACAAATACAAGAAGGGCAAGACAGAAATTTATCTTAAAGACAGCGTCGCTTTGGATCATTTTTTAATTGAGCATGGCATCAATTCGGTGGATATTGAAGGGATTGGCAAGAACGATTTGATGAACTTGTTAAAAGTGGCACGCCATTACCGCTATGCGCTTTTGGAATTAGAAAAACGCTACAATTTGCTAGAAATTTTACGCTTTCTCATTGAAACTAAGGACGCCTTAAGCCTTGATATGAAAGTTTTAGAAAAAAGCATTTTAGAAAAATTAGAGGGCTTGAATTATCAGATCTTACGCTCTTTTGCCACTGAAGAAAGCTTACATTTGCACACGCAAACCCCTAAAGGCTTGGTGGAATTTAACCTAGATGACAATCTCTTTAAAGAAGTGTTGTTTGAAGAAGCGAATTACACTTACCAAAAGCTTATGGAGTATAATTTAGACTTCTTAGAAAATAAGGATATTTTGGCGTTTTTAGAAGAAGTGGAAAATCACGCTAAAAAGGGAGCGAATATCCAGCGCTATAAGGGGCTAGGCGAGATGAACCCTAATGATTTGTGGGAAACGACCATGCATAAAGAAAACCGCAGCTTGATCAAACTCAAAATTGAAGATTTAGAAAAAACCGATGCAGTCTTTTCGCTTTGCATGGGCGATGAAGTAGAGCCTAGAAGAGCCTTTATCCAAGCGCATGCTAAAGATGTGAAACAACTAGATGTGTAA", "fmax": "530007", "accession": "NC_000915.1", "fmin": "527685", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori", "NCBI_taxonomy_id": "210", "NCBI_taxonomy_cvterm_id": "36906"}, "protein_sequence": {"accession": "WP_001182024.1", "sequence": "MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINITLTDEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPTSELEIIGKTKSAKESGTTIEFFPDESVMEVVEFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIISFKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIGNNIKTKESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESLHLHTQTPKGLVEFNLDDNLFKEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV"}}}}, "model_name": "Helicobacter pylori gyrB conferring resistance to fluoroquinolones", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}, "37244": {"category_aro_name": "fluoroquinolone resistant gyrB", "category_aro_cvterm_id": "37244", "category_aro_accession": "3000864", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Point mutations in DNA gyrase subunit B (gyrB) observed in Mycobacterium tuberculosis can result in resistance to fluoroquinolones."}}, "ARO_name": "Helicobacter pylori gyrB conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "CARD_short_name": "Hpyl_gyrB_FLO", "ARO_id": "45613", "model_type_id": "40293"}, "5752": {"model_id": "5752", "ARO_accession": "3007052", "model_param": {"40438": {"param_value": {"12491": "45612,N87K,V199I+45613,D484K", "12490": "45612,N87K,V199A+45613,D481E,R484K", "12493": "45612,D91N+45613,R484K", "12492": "45612,A129T+45613,S479G", "12486": "45612,D91G,V199I+45613,D481E", "12487": "45612,D91N+45613,D481E,D484K", "12488": "45612,D91N,V199I+45613,D481E,D484K", "12489": "45612,N87K+45613,F438S", "12495": "45612,N87Y+45613,R484K", "12494": "45612,D91N,A129T+45613,S479G"}, "param_type_id": "40438", "param_type": "co-dependent single resistance variant", "param_description": "A model parameter to describe mutations in multiple genes or proteins where resistance is co-dependent on each. For example, the G247S SNP in M. tuberculosis gyrA does not confer resistance to fluoroquinolones. However, when the D500N SNP is also present in gyrB, resistance is conferred. In this case, gyrA G247S is co-dependent on gyrB D500N to confer resistance. This parameter is noted on relevant models with the following notation: [cvterm-id-gene-1],[gene-1-SNP]+[cvterm-id-gene-2],[gene-2-SNP]+ ... +[cvterm-id-gene-n],[gene-n-SNP] e.g. 39879,G247S+40052,D500N. This parameter is not currently included in any detection algorithms."}, "blastp_bit_score": {"param_value": "1400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}, "snp": {"param_type": "single resistance variant", "param_value": {"12365": "D34N", "12362": "V172I", "12545": "D91N", "12369": "G85C", "12546": "D91Y", "12358": "D99V", "12544": "D91G", "12543": "N87I", "12542": "N87Y", "12541": "N87K", "12352": "T87I", "12353": "A88P", "12354": "D91H"}, "clinical": {"12365": "D34N", "12362": "V172I", "12545": "D91N", "12369": "G85C", "12546": "D91Y", "12358": "D99V", "12544": "D91G", "12543": "N87I", "12542": "N87Y", "12541": "N87K", "12352": "T87I", "12353": "A88P", "12354": "D91H"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}, "40330": {"param_value": {"12367": "D91G,D161N", "12364": "R140K,D192N", "12361": "S63P, R130K", "12360": "D91N, R130K", "12368": "D34Y,R140K", "12349": "D91N, V77A", "12359": "N87K, D91N, V172I", "12355": "N87A, A88N, V65I", "12350": "D91N, A97V", "12351": "D91Y, A97V", "12356": "S63P, D91N", "12357": "S63P, N87K, P188S", "12346": "N87K, H57Y"}, "param_type_id": "40330", "param_type": "multiple resistance variants", "param_description": "A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms."}}, "ARO_description": "Point mutations in the quinolone resistance-determining regions of Helicobacter pylori observed to confer resistance to fluoroquinolone antibiotics.", "model_sequences": {"sequence": {"8325": {"dna_sequence": {"partial": "0", "sequence": "ATGCAAGATAATTCAGTCAATGAAACAAAAAATATTGTAGAAGTGGGGATTGATTCTTCTATTGAAGAGAGCTATTTAGCTTATTCCATGAGCGTGATCATAGGGCGCGCTTTACCGGACGCTAGAGATGGCTTAAAGCCCGTGCATAGGCGTATTTTGTATGCGATGCATGAATTAGGCCTTACTTCAAAAGTCGCTTACAAAAAAAGCGCTAGGATCGTGGGTGATGTGATTGGTAAATACCACCCCCATGGCGATAATGCGGTTTATGATGCGCTAGTGAGAATGGCGCAAGATTTTTCCATGCGTTTGGAATTAGTGGATGGGCAGGGCAACTTTGGCTCTATTGATGGCGATAACGCCGCAGCGATGCGTTACACTGAAGCCAGAATGACTAAGGCGAGTGAAGAAATTTTAAGGGATATTGATAAAGACACCATTGATTTTGTGCCTAATTATGACGATACCTTAAAAGAGCCAGATATTTTACCAAGCCGTCTGCCTAACCTTTTAGTCAATGGGGCTAATGGGATCGCTGTGGGGATGGCGACTTCTATCCCCCCTCACAGGATGGATGAAATCATAGACGCTTTAGTGCATGTCTTAGAAAACCCTAACGCTGGATTAGATGAAATCTTAGAATTTGTCAAAGGGCCTGATTTTCCCACTGGTGGGATCATTTATGGCAAGGCGGGTATTATTGAAGCCTATAAAACGGGGCGAGGACGCGTGAAAGTGCGGGCCAAAGTGCATGTGGAAAAAACAAAAAATAAAGAAATCATCGTTTTAGATGAAATGCCTTTTCAAACCAATAAAGCCAAATTAGTGGAACAAATCAGCGATTTAGCGCGAGAAAAGCAAATTGAAGGCATTAGTGAAGTGCGCGATGAGAGCGATAGAGAGGGCATTAGAGTGGTGATTGAATTAAAAAGAGACGCGATGAGTGAAATTGTCTTAAACCACCTCTACAAACTCACCACTATGGAAACCACTTTTAGCATCATTTTACTCGCTATTTACAATAAAGAGCCTAAGATTTTCACGCTTTTAGAGTTGTTGCACCTTTTCTTAAACCACAGAAAAACCATTATTATAAGACGCACGATTTTTGAATTAGAAAAGGCTAAGGCCAGAGCGCATATTTTAGAGGGCTATTTGATCGCACTAGACAATATTGATGAAATCGTGCGACTCATTAAAACAAGCCAAAGCCCAGAAGCGGCTAAAAACGCCTTAATGGAGCGTTTCACTTTGAGCGAGATTCAAAGCAAGGCCATTTTAGAAATGCGTTTGCAACGCTTAACAGGCCTTGAAAGGGATAAGATCAAAGAAGAATACCAAAACTTGTTGGAGCTTATTGATGATCTCAATGGCATTTTAAAGAGCGAAGATCGCTTGAATGGAGTCGTCAAAACAGAGCTTTTAGAAGTCAAAGAGCAATTTTCTTCTCCAAGGCGCACTGAAATTCAAGAATCTTATGAAAATATTGACATAGAAGATTTGATCGCTAATGAGCCTATGGTAGTGAGCATGAGTTATAAAGGCTATGTGAAAAGAGTGGATTTAAAAGCTTATGAAAAGCAAAATCGTGGTGGTAAAGGCAAGCTTTCAGGCAGCACTTATGAAGACGATTTCATTGAAAACTTTTTTGTGGCTAACACGCATGATATTTTGCTCTTTATCACCAATAAGGGGCAATTGTATCATTTGAAAGTCTATAAAATCCCAGAAGCGAGCCGGATCGCTATGGGTAAAGCCATTGTAAATTTAATCTCGCTCGCTCCGGATGAAAAGATCATGGCGACTCTAAGCACCAAAGACTTTAGCGATGAACGCTCTTTGGCCTTCTTCACGAAAAATGGCGTGGTGAAGCGCACCAATTTGAGCGAATTTGAAAGCAACAGGAGTTGTGGTATCAGAGCGATTGTTTTAGATGAAGGCGATGAATTAGTGAGCGCAAAAGTTGTGGATAAAAACGCTAAGCATTTGCTCATCGCATCGCATTTGGGCATTTTCATTAAATTCCCTTTAGAAGAGGTGCGCGAGATCGGAAGAACTACTCGTGGGGTTATAGGCATCAAGCTGAATGAAAACGATTTTGTTGTCGGTGCGGTCGTTATTAGCGATGATGGCAACAAGCTTTTGAGCGTGAGTGAAAACGGGCTTGGCAAGCAAACTTTAGCCGAAGCGTATAGAGGGCAATCTCGTGGAGGTAAGGGGGTCATTGGCATGAAGCTCACTCAAAAAACCGGCAATCTAGTGGGCGTTATCAGCGTGGATGATGAAAATTTGGATTTGATGATCCTTACTGCAAGCGCAAAAATGATCAGAGTTTCTATTAAAGATATTAGAGAAACCGGAAGAAACGCTAGTGGGGTAAAGCTCATAAACACCGCCGATAAAGTCATGTATGTCAATTCTTGCCCTAAAGAAGAAGAGCCAGAAAATTTAGAAACCTCTTCGGCACAAAATTTGTTTGAGTGA", "fmax": "754995", "accession": "NC_000915.1", "fmin": "752511", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori", "NCBI_taxonomy_id": "210", "NCBI_taxonomy_cvterm_id": "36906"}, "protein_sequence": {"accession": "WP_001153763.1", "sequence": "MQDNSVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGKYHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAVGMATSIPPHRMDEIIDALVHVLENPNAGLDEILEFVKGPDFPTGGIIYGKAGIIEAYKTGRGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLHLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIKTSQSPEAAKNALMERFTLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEDRLNGVVKTELLEVKEQFSSPRRTEIQESYENIDIEDLIANEPMVVSMSYKGYVKRVDLKAYEKQNRGGKGKLSGSTYEDDFIENFFVANTHDILLFITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKNGVVKRTNLSEFESNRSCGIRAIVLDEGDELVSAKVVDKNAKHLLIASHLGIFIKFPLEEVREIGRTTRGVIGIKLNENDFVVGAVVISDDGNKLLSVSENGLGKQTLAEAYRGQSRGGKGVIGMKLTQKTGNLVGVISVDDENLDLMILTASAKMIRVSIKDIRETGRNASGVKLINTADKVMYVNSCPKEEEPENLETSSAQNLFE"}}}}, "model_name": "Helicobacter pylori gyrA conferring resistance to fluoroquinolones", "ARO_category": {"35988": {"category_aro_name": "levofloxacin", "category_aro_cvterm_id": "35988", "category_aro_accession": "0000071", "category_aro_class_name": "Antibiotic", "category_aro_description": "Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Its main target is topoisomerase IV, inhibiting its function and disrupting DNA replication."}, "35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}, "39876": {"category_aro_name": "fluoroquinolone resistant gyrA", "category_aro_cvterm_id": "39876", "category_aro_accession": "3003292", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit."}}, "ARO_name": "Helicobacter pylori gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "CARD_short_name": "Hpyl_gyrA_FLO", "ARO_id": "45612", "model_type_id": "40293"}, "5737": {"model_id": "5737", "ARO_accession": "3007026", "model_param": {"blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "salB is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins.", "model_sequences": {"sequence": {"8291": {"dna_sequence": {"partial": "0", "sequence": "ATGCTATTTTTATTTGAAGAAAAACCATTAGAAATTGAGAATAAACAGCTTATAAAACGTTTGTCATTTCATATCGAAGACCATGAGCATTTAGCCCTTATCGGTGTTAATGGTATTGGTAAATCTACGCTATTACATCATATTCATAAAAATGAATTGATTGATACAGCTATGATGGAACAAGATTTAAGTAAACATGATGATATTGATGTTATGGATTATGTCATGTCTGCATATCCAAAGTTAGTTGAATTGAGAAAAGATTTATCTGACATTGATTCTTTAAATAGTTATATAGAATTAGACGGATATAACGTTGAAAATAACATTATTATTGAAGGAAATAAATTAGGATTATCATCAACACATTTTGAGCAAAAGATAGGCACTTTAAGTGGTGGTGAGCAAACTAAAGTCTCATTTTTAAAAGTTATTTTATCAGATGCACCATTATTATTAATAGACGAACCAACTAACCATATGGATAAAGAGATGAAAGTGTGGTTAATAAAAGCTTTTAAATCAGAACAAAGAGCTATTCTATTCGTATCGCATGATAGAGAGTTTTTAAATGAAACACCAGATGCTATTTTAGAACTCACAAAAGATGGTGCAACTCGATATTCAGGTCATTATGATGATTATAAAAATCAAAAAGATATTGAAATTGAAACAGAAAAATTAAAATATGAAAAAGAACAGAAAGAACAAAAAGCAATAGAAGAAAGTATTAAGAAATACAAAGAATGGTATCAAAGGGCTGCTCAGAAAGCTTCTGTTCGTAGTCCATATGCTCAAAAACAATTAAGTAAATTAGCTAAAAGATTTAAATCAAAAGAACATCAGTTAAATCGTAAATTAGAAGAATCAAAATCTGATAATCCGTTAGAAGAAAATAAATCCTTTTCTATAGAAAATAATGAATTTAAATCACATTATTTAGTAAGATTCGAAAATGTTTCATTTTCATATAAGAGTCGTGAAATTTTTAAAGACACTTATTTTGAAATAAAGAGAAATCAAACTGTAATTATAGAAGGTAAAAATGGGTCCGGTAAATCTACATTGATACAATTAATTTTAGGTAACTTATTACCAATGAGTGGAGCTGTCAAAAAGCACCCAGACTTAGACATAGGATACTTCTCGCAAGATTTTCAAAATTTAAACCCAAACAACTCGGTATTAGAAGAAGTTATGGATATTGAGAATATGATGATAACAGACGCGAGGACTATTTTAGCGAGTTTTTATTTTGATAAGAGCAGGATGAATGATAAAGTTCGTCAGTTATCAATGGGAGAAAAGTGCAGGTTACAATTTGTAAAATTATATTTTTCTAACCCACACATCTTAATTTTAGATGAACCAACTAATTATTTTGATATTAGTATGCAAGAGAAAATCATACAATTAATCCAAAGTTTTAATGGTGCAGTAATTATTGTGTCGCATGATGAAATTTTTAAAGATGAAATAAGAGACCAAGTTTGGAAGATTGAAAACTGTAAGCTCATTCATGAAAATGTATCTATTAATACACCTATTGATGCTGAATCGATGAAGGATGAGTTAAAAATATTAGAGCAATATACAGATGAAAGAAATAAAGAAACAGACTTCTAG", "fmax": "189242", "accession": "JAHWBZ010000013.1", "fmin": "187616", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mammaliicoccus lentus", "NCBI_taxonomy_id": "42858", "NCBI_taxonomy_cvterm_id": "39555"}, "protein_sequence": {"accession": "MBW0770001.1", "sequence": "MLFLFEEKPLEIENKQLIKRLSFHIEDHEHLALIGVNGIGKSTLLHHIHKNELIDTAMMEQDLSKHDDIDVMDYVMSAYPKLVELRKDLSDIDSLNSYIELDGYNVENNIIIEGNKLGLSSTHFEQKIGTLSGGEQTKVSFLKVILSDAPLLLIDEPTNHMDKEMKVWLIKAFKSEQRAILFVSHDREFLNETPDAILELTKDGATRYSGHYDDYKNQKDIEIETEKLKYEKEQKEQKAIEESIKKYKEWYQRAAQKASVRSPYAQKQLSKLAKRFKSKEHQLNRKLEESKSDNPLEENKSFSIENNEFKSHYLVRFENVSFSYKSREIFKDTYFEIKRNQTVIIEGKNGSGKSTLIQLILGNLLPMSGAVKKHPDLDIGYFSQDFQNLNPNNSVLEEVMDIENMMITDARTILASFYFDKSRMNDKVRQLSMGEKCRLQFVKLYFSNPHILILDEPTNYFDISMQEKIIQLIQSFNGAVIIVSHDEIFKDEIRDQVWKIENCKLIHENVSINTPIDAESMKDELKILEQYTDERNKETDF"}}}}, "model_name": "salB", "ARO_category": {"37713": {"category_aro_name": "retapamulin", "category_aro_cvterm_id": "37713", "category_aro_accession": "3001314", "category_aro_class_name": "Antibiotic", "category_aro_description": "Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections."}, "37013": {"category_aro_name": "virginiamycin M1", "category_aro_cvterm_id": "37013", "category_aro_accession": "3000669", "category_aro_class_name": "Antibiotic", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}, "37014": {"category_aro_name": "pleuromutilin antibiotic", "category_aro_cvterm_id": "37014", "category_aro_accession": "3000670", "category_aro_class_name": "Drug Class", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes."}, "37015": {"category_aro_name": "tiamulin", "category_aro_cvterm_id": "37015", "category_aro_accession": "3000671", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "35964": {"category_aro_name": "lincomycin", "category_aro_cvterm_id": "35964", "category_aro_accession": "0000046", "category_aro_class_name": "Antibiotic", "category_aro_description": "Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction."}, "41687": {"category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_cvterm_id": "41687", "category_aro_accession": "3004469", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins."}, "35999": {"category_aro_name": "antibiotic target protection", "category_aro_cvterm_id": "35999", "category_aro_accession": "0001003", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "36218": {"category_aro_name": "oxazolidinone antibiotic", "category_aro_cvterm_id": "36218", "category_aro_accession": "3000079", "category_aro_class_name": "Drug Class", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use."}, "35983": {"category_aro_name": "clindamycin", "category_aro_cvterm_id": "35983", "category_aro_accession": "0000066", "category_aro_class_name": "Antibiotic", "category_aro_description": "Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria."}, "36526": {"category_aro_name": "phenicol antibiotic", "category_aro_cvterm_id": "36526", "category_aro_accession": "3000387", "category_aro_class_name": "Drug Class", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "salB", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "salB", "ARO_id": "45570", "model_type_id": "40292"}, "5736": {"model_id": "5736", "ARO_accession": "3007023", "model_param": {"blastp_bit_score": {"param_value": "554", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "NDM-33 confers resistance to all beta-lactam antibiotics except aztreonam. It was first identified in an E. coli strain isolated from hospital sewage. It differs from NDM-5 by a single amino acid substitution (A72T).", "model_sequences": {"sequence": {"8132": {"dna_sequence": {"partial": "0", "sequence": "ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGACAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGTTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAGAGGGGCTGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA", "fmax": "10765", "accession": "MZ004933.1", "fmin": "9952", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "UBU60937.1", "sequence": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGTVASNGLIVRDGGRVLLVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"}}}}, "model_name": "NDM-33", "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "35977": {"category_aro_name": "ceftazidime", "category_aro_cvterm_id": "35977", "category_aro_accession": "0000060", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections."}, "35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36196": {"category_aro_name": "NDM beta-lactamase", "category_aro_cvterm_id": "36196", "category_aro_accession": "3000057", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins."}, "35954": {"category_aro_name": "ciprofloxacin", "category_aro_cvterm_id": "35954", "category_aro_accession": "0000036", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome."}, "35962": {"category_aro_name": "cephamycin", "category_aro_cvterm_id": "35962", "category_aro_accession": "0000044", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}}, "ARO_name": "NDM-33", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "NDM-33", "ARO_id": "45495", "model_type_id": "40292"}, "5731": {"model_id": "5731", "ARO_accession": "3007015", "model_param": {"blastp_bit_score": {"param_value": "75", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "qacG is a small multidrug resistance efflux pump that confers resistance to benzalkonium chloride and ethidium bromide.", "model_sequences": {"sequence": {"8127": {"dna_sequence": {"partial": "0", "sequence": "ATGCATTATTTATATTTATTTATCTCAATTGCAACAGAAATAATCGGAACTAGTTTTTTAAAAACATCAGAAGGTTTCACAAAGTTATGGCCAACATTAGGTACACTACTTTCGTTTGGAATTTGCTTTTATTTTTTAAGTTTAACAATAAAATTTTTGCCCTTAAATATAACTTACGCAACATGGGCAGGTCTAGGATTAGTATTAACAACAATAATCTCAGTTATCGTTTTTAAAGAAAATGTTAATTTAATTAGTATAATTTCTATTGGCTTAATTGTTATAGGTGTAGTGCTCTTAAATGTATTTGGAGAAAGCCATTGA", "fmax": "424", "accession": "NG_051904.1", "fmin": "100", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance", "NCBI_taxonomy_id": "2", "NCBI_taxonomy_cvterm_id": "35506"}, "protein_sequence": {"accession": "WP_015740450.1", "sequence": "MHYLYLFISIATEIIGTSFLKTSEGFTKLWPTLGTLLSFGICFYFLSLTIKFLPLNITYATWAGLGLVLTTIISVIVFKENVNLISIISIGLIVIGVVLLNVFGESH"}}}}, "model_name": "qacG", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "40514": {"category_aro_name": "benzalkonium chloride", "category_aro_cvterm_id": "40514", "category_aro_accession": "3003823", "category_aro_class_name": "Antibiotic", "category_aro_description": "Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent."}, "36004": {"category_aro_name": "small multidrug resistance (SMR) antibiotic efflux pump", "category_aro_cvterm_id": "36004", "category_aro_accession": "0010003", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "qacG", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "qacG", "ARO_id": "45484", "model_type_id": "40292"}, "5756": {"model_id": "5756", "ARO_accession": "3007057", "model_param": {"blastp_bit_score": {"param_value": "1000", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}, "snp": {"param_type": "single resistance variant", "param_value": {"12389": "F490Y", "12388": "A50S", "12385": "E536K", "12384": "A499V", "12387": "D2N", "12390": "A541T", "12391": "V374I"}, "clinical": {"12389": "F490Y", "12388": "A50S", "12385": "E536K", "12384": "A499V", "12387": "D2N", "12390": "A541T", "12391": "V374I"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}}, "ARO_description": "Point mutations in Helicobacter pylori pbp3 observed to confer resistance to amoxicillin.", "model_sequences": {"sequence": {"8371": {"dna_sequence": {"partial": "0", "sequence": "ATGGATAATAAAAACATTGATCCCAACTTCAACCCAGAACGATTTTTAGAAACCCAAAAATACAAGGGCTCTATTACGGCTTTAATCTTTTTATTGCTTTTTTTTATTTTTTTAATGGTGGCTTTTAAAAAAGCTTTTTTTGCCCAAGCCAACATGCCTAATCTAGTGATGAGCAAACAAGACACTGCGGCTAGGGGGACTATCTATAGTCAAGACAACTACAGCCTAGCCGCTTCGCAAACCCTTTTCAAACTGGGCTTTGATACAAGGTTTTTAAACCCGGATAAAGAAGATTTTTTCATTGATTTCCTTTCTATTTATAGCAATATCCCTAAAAAGTCCTTAAAAGACGCCATCAATACGAAAGGCTATATTATTCTAGCCTATGATCTCACGCCCAATATGGCCGCTAACATTAGAGACTTGAATAAGAAATTTTTAGCCTTTGGGGTTTTTCAAAATTTCAAAGACGCGCACGATAAGGTGTGGCAAAAGCAAGGGCTAAACATTGAAGTGAGCGGCGTTTCCAGGCATTACCCTTATCAAAATAGCCTAGAGCCAATCATTGGCTATGTGCAAAAACAAGAAGAAGACAAGCTCACTTTAACTACCGGTAAAAAAGGCGTTGAAAAATCTCAAGATCACTTGCTTAAAGCCCAACAAAATGGCATAAGAACAGGCAAAAGAGATGTGAGTTTTAATTTTATTCAAAACCACTCTTACACAGAGGTTGAGCGCCTTGATGGCTATGAGGTGTATTTGAGCATTCCTTTAAAACTCCAAAGAGAAATTGAAACCCTATTGGATAAAACCAAAGACAAACTCAAGGCTAAAGAAATCCTAGTGGGTATCATTAACCCTAAAAGCGGGGAAATCTTATCGCTAGCTTCAAGCAAGCGCTTCAATCCTAACGCCATTAAAACCAGCGATTATGAAAGCTTGAATTTGAGCGTTGCCGAAAAGGTTTTTGAGCCAGGCAGCACGATCAAACCCATTGTTTATTCCTTGCTGTTAGACAAGAATTTGATCAACCCTAAAGAACGCATTGATTTAAACCATGGCTATTACCAATTAGGAAAATACACCATTAAAGACGACTTTATCCCTAGTAAAAAAGCCGTTGTGGAAGATATTTTGATCCAATCTAGCAATGTGGGCATGATAAAAATCAGCAAAAATCTCAACCCGGAGGATTTCTATAATGGGCTTTTAGGCTATGGATTTTCTCAAAAAACCGGCATTGATTTATCCTTAGAAGCCACAGGAAAGATCCCTCCTTTGTCCGCTTTCAAGCGTGAAGTGTTAAAGGGGAGCGTCTCTTATGGCTATGGGCTGAACGCGACTTTTTTGCAGCTTTTAAGGGCTTATGCGGTGTTTTCTAATGAAGGCAAATTGACTACCCCCTATTTAGTGCAACGAGAGACCGCCCCTAATGGCGATATTTACATCCCTAGCCCCAAACCCACTTTTCAAGTCATTAGCCCCAAAAGCGCCAGGAAAATGAAAGAAACCTTAATCAAAGTGGTGCGTTATGGCACAGGCAAAAACGCTCAATTTGAAGGGTTATACATAGGGGGCAAAACAGGCACGGCTAGGGTTGCTAAAAACGGGAGTTACAGCGCGGAATCCTACAACAGCTCTTTTTTTGGGTTCGCTGAAGATGAAAGGCAGGTTTTTACTATCGGCGTGGTTATCTTAGGCTCGCACGGCAAGGAAGAATATTATGCTAGCAAGATTGCAGCCCCTATTTTTAAAGAAATCACCGAAATTTTAGTGCGTTACAATTACCTATCGCCCTCTATTGCGATTCAAAACGTGCTCGAGAAAAACCGCTTTAAGATAAAATAA", "fmax": "219672", "accession": "AKPU01000002.1", "fmin": "217824", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori Hp P-30", "NCBI_taxonomy_id": "992087", "NCBI_taxonomy_cvterm_id": "45618"}, "protein_sequence": {"accession": "EJC52487.1", "sequence": "MDNKNIDPNFNPERFLETQKYKGSITALIFLLLFFIFLMVAFKKAFFAQANMPNLVMSKQDTAARGTIYSQDNYSLAASQTLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAINTKGYIILAYDLTPNMAANIRDLNKKFLAFGVFQNFKDAHDKVWQKQGLNIEVSGVSRHYPYQNSLEPIIGYVQKQEEDKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHSYTEVERLDGYEVYLSIPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSKRFNPNAIKTSDYESLNLSVAEKVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGKYTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPEDFYNGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGDIYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSAESYNSSFFGFAEDERQVFTIGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSIAIQNVLEKNRFKIK"}}}}, "model_name": "Helicobacter pylori pbp3 conferring resistance to amoxicillin", "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "40661": {"category_aro_name": "Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics", "category_aro_cvterm_id": "40661", "category_aro_accession": "3003938", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}, "35981": {"category_aro_name": "amoxicillin", "category_aro_cvterm_id": "35981", "category_aro_accession": "0000064", "category_aro_class_name": "Antibiotic", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan."}, "35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35962": {"category_aro_name": "cephamycin", "category_aro_cvterm_id": "35962", "category_aro_accession": "0000044", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases."}}, "ARO_name": "Helicobacter pylori pbp3 conferring resistance to amoxicillin", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "CARD_short_name": "Hpyl_pbp3_AMX", "ARO_id": "45617", "model_type_id": "40293"}, "5733": {"model_id": "5733", "ARO_accession": "3007019", "model_param": {"blastp_bit_score": {"param_value": "520", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "FexB is a plasmid-encoded exporter gene which confers resistance to florfenicol. Originally identified in Enterococcus sp. isolated from swine by Liu et al. 2012.", "model_sequences": {"sequence": {"8130": {"dna_sequence": {"partial": "0", "sequence": "ATGAATCATCAAAATGAAAAAAATATAGCATCAAATGTGTTGTTAATTAGTATCTTAGGCTTGTCTGTTTTAGTGGGTTCAGTTACTGCAGATATGGTTAATCCTGTTCTCGGTGTGATTGGAAAAGAATTAGGTGGGTCTGAGGCGCAAGTTAGTTGGGTCGTAAGTGGTGTTGCCTTAGTTCTATCTATAGCAATTCCCTTTTATGGACGTTTATCTGATTTTTTAAATATTAAAAAACTCTTTACTAACGGATTTCTAATATTAACTATAGGAAGTTTAATATGTATATTCGCGCCCAATTTAATTATTTTAGTATTGGGTAGAATGTTTCAAGGAGCTGGCATGGCAGCCATACCTGTGCTATCTATTGTTATAATATCTAAAATTTATCCGCCTGGACAGAGAGGAAGAATTTTAGGTATTATTGCTGGTTGTATTGGCGTTGGCACTGCAGGAGGCCCAATATTTGGCGGCGTTGTAGGACAATTATTAGGTTGGCAATCATTATTTTGGGTCACTTTTGTTCTGGGTTTAATTATAGTTCTAGGTGTTCAAATATCAATGCCTAAAATAGAATCACCAGATAATAACAGTCATCAAAATTTTGATGTTTTAGGTGGACTATTATTAGGATTAACCGTAGGTGGTTTTTTACTTGGTATTACGCTTTCAGAAATGTATGGTTTGATTTCTATACAAACAACCACAAGTTTTTCTATATCTATGATAGCTTTAATAGTGTTAATATATCGCGTGATTAATGTTAAAAATCCTTTTATCCCTCCAGTTATATTGAAGAACCGTTTATATGTAAGCTCAATTTTCATTGTATTTCTTTCAATGTTTGCTTATGTCTCTATGCTTGTTTTTATTCCATTATTAGTTGTTGAGGTTAATGGGTTAAGTACTGGACAGGCAGGCTTAATATTACTTTCTGGTGGTGTCGCTGTTGCAATCCTTTCACCAATAGTGGGAAGATTATCTGACAAAGTGCATCCTAAAATACTATTATTAGTTGGACTAATTATTATGGGCTTATCTTCTTTATATATGAGCTTCGTAGCAGGCGCATCACCTGTATTATTATCTATCGGGAGTTTAGGGATAGGTATCGCTTTTGCATTTATTAACTCTCCAGTGAATAATGTTGCAGTACTTGCTTTACCTAAAGAACAAGTTGGTGTAGGTACGGGGTTGTTTCAAGGTGCAATGTATCTTGGGGCAGGAACAGGTGCCTCACTAATAGGGGCTTTATTGTCAATGAGACATGGGGTTAAAGCATCTTTTAATCCTTTTTATACTTTAACTGCCCCGCACTATTCTGATATATTTTTAACCATTACGTGCATCGTGTTAGTTGCTTTAATTGTTACTTTAAATATAAGTAGTAGGGATTTAAAGCAATAA", "fmax": "12046", "accession": "JN201336.1", "fmin": "10636", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterococcus faecium", "NCBI_taxonomy_id": "1352", "NCBI_taxonomy_cvterm_id": "36779"}, "protein_sequence": {"accession": "AEV23046.1", "sequence": "MNHQNEKNIASNVLLISILGLSVLVGSVTADMVNPVLGVIGKELGGSEAQVSWVVSGVALVLSIAIPFYGRLSDFLNIKKLFTNGFLILTIGSLICIFAPNLIILVLGRMFQGAGMAAIPVLSIVIISKIYPPGQRGRILGIIAGCIGVGTAGGPIFGGVVGQLLGWQSLFWVTFVLGLIIVLGVQISMPKIESPDNNSHQNFDVLGGLLLGLTVGGFLLGITLSEMYGLISIQTTTSFSISMIALIVLIYRVINVKNPFIPPVILKNRLYVSSIFIVFLSMFAYVSMLVFIPLLVVEVNGLSTGQAGLILLSGGVAVAILSPIVGRLSDKVHPKILLLVGLIIMGLSSLYMSFVAGASPVLLSIGSLGIGIAFAFINSPVNNVAVLALPKEQVGVGTGLFQGAMYLGAGTGASLIGALLSMRHGVKASFNPFYTLTAPHYSDIFLTITCIVLVALIVTLNISSRDLKQ"}}}}, "model_name": "fexB", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "36003": {"category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_cvterm_id": "36003", "category_aro_accession": "0010002", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient."}, "36526": {"category_aro_name": "phenicol antibiotic", "category_aro_cvterm_id": "36526", "category_aro_accession": "3000387", "category_aro_class_name": "Drug Class", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome."}, "36600": {"category_aro_name": "florfenicol", "category_aro_cvterm_id": "36600", "category_aro_accession": "3000461", "category_aro_class_name": "Antibiotic", "category_aro_description": "Florfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "fexB", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "fexB", "ARO_id": "45490", "model_type_id": "40292"}, "5732": {"model_id": "5732", "ARO_accession": "3007017", "model_param": {"blastp_bit_score": {"param_value": "350", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "SHD-1 is a SHD beta-lactamase.", "model_sequences": {"sequence": {"8128": {"dna_sequence": {"partial": "0", "sequence": "ATGGAGTTTTCAAGAATGATGTTAAATCTAGTGCGCAAGGTGTTCACTACGGGGCCCAGAGTGCTCAGTGTTGTCAGCTTGCTAAGTGTTAACGTATTAGGCATAAACTTGGCACAGGCTGTGACTAGCGAGGAAAGCGTACCGAAATTTAGCATTGAGCCATTAGCCAATAATGTGTATTTGCACCAGTCCTTTCAACAGACTGAAAGTTTTGGCCTAGTCGGCGCCAATGGCTTAGTGGTGATTAATGAGGGAAAGGCCTTTATCGTCGATACCCCTTGGTCTGAAAGTGACACTGCGGTGCTGGTTGATTGGATTAAAGAACAAGGTTATCAATTGGTTGGCAGTGTATCAACTCACTCACATGAAGACAGAACAGCAGGCATAGGCTGGCTCAATGCTCACAGTATTCCGACATTTGCCTCTGAATTAACCAATCAGATTTTAAAAGAATCGGAAAAGCCGCTGGCAAGCCATCCTTTTGCACTGCCACAGGCGAGTTTGTTTGATGGCCAGCTGGAGGCATTTTATCCCGGTGGTGGGCATGCGCTAGATAATTTAGTGGTCTGGTTGCCTAAATCAAATATTCTCTTTGGCGGCTGTTTAGTTCGCAGCTTAGACTCAACAAGCCTAGGCTACACGGGAGAAGCGGTGTTAGAACAATGGCCGACATCTGCGATGAAAGTGCTCGCTAAATTCCCTGATGTAGAACTTGTGGTGCCAGGCCATGGTGAGCCTGGTGATAAACAGCTGTTAATTCACACAAAGGCTTTGGCCGAATCTGGGGCGAAGCAAGCGTCAGCTAAATAA", "fmax": "910", "accession": "NG_077967.1", "fmin": "100", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shewanella denitrificans", "NCBI_taxonomy_id": "192073", "NCBI_taxonomy_cvterm_id": "45487"}, "protein_sequence": {"accession": "WP_011495276.1", "sequence": "MEFSRMMLNLVRKVFTTGPRVLSVVSLLSVNVLGINLAQAVTSEESVPKFSIEPLANNVYLHQSFQQTESFGLVGANGLVVINEGKAFIVDTPWSESDTAVLVDWIKEQGYQLVGSVSTHSHEDRTAGIGWLNAHSIPTFASELTNQILKESEKPLASHPFALPQASLFDGQLEAFYPGGGHALDNLVVWLPKSNILFGGCLVRSLDSTSLGYTGEAVLEQWPTSAMKVLAKFPDVELVVPGHGEPGDKQLLIHTKALAESGAKQASAK"}}}}, "model_name": "SHD-1", "ARO_category": {"35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "45485": {"category_aro_name": "SHD beta-lactamase", "category_aro_cvterm_id": "45485", "category_aro_accession": "3007016", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "SHD beta-lactamases are class B1 beta-lactamases found in Shewanella denitrificans."}}, "ARO_name": "SHD-1", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "SHD-1", "ARO_id": "45486", "model_type_id": "40292"}, "5759": {"model_id": "5759", "ARO_accession": "3007059", "model_param": {"40394": {"param_value": {"12455": "L39STOP", "12464": "A192STOP", "12461": "E199STOP", "12462": "K105STOP", "12463": "M149STOP", "12437": "R86STOP"}, "param_type_id": "40394", "param_type": "nonsense mutation", "param_description": "A nucleotide substitution resulting in a change from an amino acid codon to a STOP codon. Nonsense mutations truncate protein translation prematurely, resulting in a defective or completely inactive protein. In CARD, nonsense mutations may be attached to models using the notation: [wild type amino acid][position][STOP] (e.g. Q42STOP). This parameter is not currently used in detection algorithms."}, "40494": {"param_value": {"12445": "R106fs"}, "param_type_id": "40494", "param_type": "frameshift mutation", "param_description": "A frameshift is a type of genetic mutation caused by a nucleotide insertion or deletion that does not equal 3 bases. This changes the grouping of codons and thus the reading frame during translation, resulting in an incomplete or inactive protein product. Many frameshift mutations generate downstream STOP codons, resulting in premature peptide translation termination. Frameshifts may also confer antibiotic resistance through partial or total protein loss-of-function. Frameshift mutations are included with relevant models when applicable, with the following notation: [wild-type AA][position]fs;[[wild-type AA][position]STOP], where AA is an amino acid. If the premature STOP codon position is unknown or does not exist, [wild-type AA][position]fs is sufficient. Termination can also be denoted as: Ter[position]fs. This parameter is currently not included in detection algorithms."}, "40590": {"param_value": {"12443": "45615,Q11STOP+45620,Q5STOP"}, "param_type_id": "40590", "param_type": "co-dependent nonsense SNP", "param_description": "An AMR detection model parameter to describe concurrent nonsense mutations in multiple genes which produce a resistance phenotype. That is, either mutation independently will not confer resistance but co-mutation in a set of genes does. These mutation parameters are documented in CARD with the notation: [cvterm-id-gene-1],[gene-1-nonsenseSNP]+[cvterm-id-gene-2],[gene-2-nonsenseSNP]+ ... +[cvterm-id-gene-n],[gene-n-nonsenseSNP] e.g. 39879,G247S+40052,D500STOP. This is currently (August 2017) no algorithm for model detection with this parameter."}, "40438": {"param_value": {"12454": "45615,E27V+45620,V44G,Y60F", "12460": "45615,L717F,Q113STOP+45620,L39STOP", "12450": "45615,M21V,A80T,Q119STOP+45620,A70V", "12440": "45615,N73STOP+45620,R3T"}, "param_type_id": "40438", "param_type": "co-dependent single resistance variant", "param_description": "A model parameter to describe mutations in multiple genes or proteins where resistance is co-dependent on each. For example, the G247S SNP in M. tuberculosis gyrA does not confer resistance to fluoroquinolones. However, when the D500N SNP is also present in gyrB, resistance is conferred. In this case, gyrA G247S is co-dependent on gyrB D500N to confer resistance. This parameter is noted on relevant models with the following notation: [cvterm-id-gene-1],[gene-1-SNP]+[cvterm-id-gene-2],[gene-2-SNP]+ ... +[cvterm-id-gene-n],[gene-n-SNP] e.g. 39879,G247S+40052,D500N. This parameter is not currently included in any detection algorithms."}, "snp": {"param_type": "single resistance variant", "param_value": {"12473": "M126F", "12472": "I117M", "12471": "I44F", "12470": "A85V", "12468": "A16T", "12469": "A32V", "12475": "V7I", "12452": "A15V", "12502": "G441A", "12509": "V9I", "12474": "S43A", "12501": "A48G", "12508": "K97E", "12476": "Y62D", "12507": "A70G", "12451": "P41L", "12439": "R3T", "12503": "C13A"}, "clinical": {"12473": "M126F", "12472": "I117M", "12471": "I44F", "12470": "A85V", "12468": "A16T", "12469": "A32V", "12475": "V7I", "12452": "A15V", "12502": "G441A", "12509": "V9I", "12474": "S43A", "12501": "A48G", "12508": "K97E", "12476": "Y62D", "12507": "A70G", "12451": "P41L", "12439": "R3T", "12503": "C13A"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}, "40330": {"param_value": {"12447": "A15V,I144V,M66I"}, "param_type_id": "40330", "param_type": "multiple resistance variants", "param_description": "A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms."}, "blastp_bit_score": {"param_value": "420", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "FrxA encodes an NADH-flavin oxidoreductase in Helicobacter pylori. Mutations in this gene confer resistance to nitrofuran antibiotics and metronidazole.", "model_sequences": {"sequence": {"8317": {"dna_sequence": {"partial": "0", "sequence": "ATGGACAGAGAACAAGTGGTTGCTTTACAGCACCAACGATTTGCTGCAAAAAAATACGATCCTAATCGTCGTATTTCCCAAAAGGATTGGGAAGCTTTGGTTGAAGTGGGGAGATTAGCCCCTTCTTCAATCGGGCTTGAACCATGGAAAATGCTTTTATTGAAAAATGAACGCATGAAAGAAGATTTAAAACCGATGGCCTGGGGGGCGCTTTTTGGTTTGGAGGGAGCGAGCCATTTTGTCATTTATCTTGCGCGAAAAGGCGTTACTTATGACAGCGATTACGTTAAAAAAGTGATGCATGAGGTTAAAAAAAGGGATTATGACACTAATTCTAGGTTCGCTCAAATCATCAAAAATTTCCAAGAGAACGATATGAAACTCAATAGCGAACGATCTTTGTTTGATTGGGCTAGCAAGCAGACTTATATCCAAATGGCGAACATGATGATGGCAGCGGCCATGTTAGGGATTGATTCTTGCCCGATTGAAGGGTATGATCAAGAAAAAGTGGAGGCTTATTTAGAGGAAAAAGGCTATCTGAACACGGCGGAATTTGGCGTGTCGGTAATGGCTTGTTTTGGTTATCGTAACCAAGAAATCACCCCTAAAACCCGCTGGAAGACAGAAGTTATTTATGAAGTGATTGAATAA", "fmax": "688581", "accession": "AE000511.1", "fmin": "687927", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori 26695", "NCBI_taxonomy_id": "85962", "NCBI_taxonomy_cvterm_id": "36758"}, "protein_sequence": {"accession": "AAD07703.1", "sequence": "MDREQVVALQHQRFAAKKYDPNRRISQKDWEALVEVGRLAPSSIGLEPWKMLLLKNERMKEDLKPMAWGALFGLEGASHFVIYLARKGVTYDSDYVKKVMHEVKKRDYDTNSRFAQIIKNFQENDMKLNSERSLFDWASKQTYIQMANMMMAAAMLGIDSCPIEGYDQEKVEAYLEEKGYLNTAEFGVSVMACFGYRNQEITPKTRWKTEVIYEVIE"}}}}, "model_name": "Helicobacter pylori frxA mutation conferring resistance to metronidazole", "ARO_category": {"41239": {"category_aro_name": "nitroimidazole antibiotic", "category_aro_cvterm_id": "41239", "category_aro_accession": "3004115", "category_aro_class_name": "Drug Class", "category_aro_description": "Nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity, classified with respect to the location of the nitro functional group."}, "45616": {"category_aro_name": "Antibiotic resistant Helicobacter pylori nitroreductase", "category_aro_cvterm_id": "45616", "category_aro_accession": "3007056", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Inactivation of the oxygen-insensitive NADPH nitroreductases in Helicobacter pylori play a role in metronidazole resistance."}, "35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "37033": {"category_aro_name": "metronidazole", "category_aro_cvterm_id": "37033", "category_aro_accession": "3000689", "category_aro_class_name": "Antibiotic", "category_aro_description": "Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death."}}, "ARO_name": "Helicobacter pylori frxA mutation conferring resistance to metronidazole", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "CARD_short_name": "Hpyl_fxrA_MTZ", "ARO_id": "45620", "model_type_id": "40293"}, "5758": {"model_id": "5758", "ARO_accession": "3007060", "model_param": {"40394": {"param_value": {"12510": "L610STOP"}, "param_type_id": "40394", "param_type": "nonsense mutation", "param_description": "A nucleotide substitution resulting in a change from an amino acid codon to a STOP codon. Nonsense mutations truncate protein translation prematurely, resulting in a defective or completely inactive protein. In CARD, nonsense mutations may be attached to models using the notation: [wild type amino acid][position][STOP] (e.g. Q42STOP). This parameter is not currently used in detection algorithms."}, "snp": {"param_type": "single resistance variant", "param_value": {"12511": "V374L", "12420": "T593A", "12421": "S414R", "12422": "G595S", "12425": "F366L", "12426": "S405N", "12427": "A474T", "12428": "T558S", "12429": "N562H", "12549": "E464N", "12550": "S595A", "12551": "S595G", "12552": "T593S", "12434": "V250I", "12433": "A201V", "12432": "N107R", "12430": "S402G", "12419": "N562Y", "12418": "T556S", "12435": "S543T", "12512": "S414N", "12513": "I450V", "12553": "T593G", "12554": "T593K"}, "clinical": {"12511": "V374L", "12420": "T593A", "12421": "S414R", "12422": "G595S", "12425": "F366L", "12426": "S405N", "12427": "A474T", "12428": "T558S", "12429": "N562H", "12549": "E464N", "12550": "S595A", "12551": "S595G", "12552": "T593S", "12434": "V250I", "12433": "A201V", "12432": "N107R", "12430": "S402G", "12419": "N562Y", "12418": "T556S", "12435": "S543T", "12512": "S414N", "12513": "I450V", "12553": "T593G", "12554": "T593K"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}, "blastp_bit_score": {"param_value": "1300", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "Point mutations in Helicobacter pylori pbp1 observed to confer resistance to amoxicillin.", "model_sequences": {"sequence": {"8369": {"dna_sequence": {"partial": "0", "sequence": "ATGCTAAAAAAGATTTTTTATGGTTTTATCGTTTTATTTTTGATTATCGTAGGGTTGTTAGCCATTCTTATCGCTCAAGTTTGGGTAACTACGGATAAGGATATTGCTAAAATTAAAGATTATCGCCCGGGCGTCGCTTCACAGATTTTAGACCGAAAAGGGCGTTTGATCGCTAATATCTATGATAAGGAATTTCGTTTTTATGCGCGTTTTGAAGAAATCCCCCCACGATTTATTGAAAGCCTTTTAGCGGTAGAAGACACCCTCTTTTTTGAACATGGGGGGATCAATTTAGACGCTATCATGCGCGCTATGATTAAAAACGCTAAAAGCGGTCGTTACACCGAGGGGGGTAGCACCCTAACCCAACAACTCGTTAAAAACATGGTGCTCACACGAGAAAAAACCCTAACCAGAAAACTCAAAGAAGCTATCATTTCCATACGCATTGAAAAAGTCTTAAGCAAAGAAGAAATTTTAGAGCGCTATTTGAACCAAACTTTTTTTGGGCATGGGTATTATGGCGTGAAAACCGCAAGTTTAGGGTATTTTAAAAAACCCCTTGACAAACTCACGCTTAAAGAAATCGCCATGTTAGTCGCCTTGCCTAGGGCTCCGAGTTTTTATGATCCTACCAAAAATTTAGAATTTTCACTTTCTAGGGCTAATGATATTTTAAGGCGGTTGTATTCTTTAGGCTGGATTTCTTCTAACGAGCTCAAATCCGCTCTCAATGAAGTGCCAATCGTCTATAACCAAACTTCCACGCAAAATATCGCTCCCTATGTCGTGGATGAAGTATTGAAGCAATTGGATCAATTAGACGGGTTAAAAACTCAAGGCTATATTATAAAGCTCACGATAGATTTGGATTACCAACGCTTAGCGTTAGAGTCCTTGCGTTTTGGGCATCAAAAAATCTTAGAAAAAATCGCTAAAGAAAAGCCAAAAACTAACGCGTCTAATGAAGATGAAGACAACTTGAACGCTAGCATGATAGTTACAGACACGAGCACCGGTAAGATTTTAGCTTTAGTGGGAGGGATTGATTATAAAAAAAGCGCTTTCAATCGCGCCACGCAAGCCAAACGGCAATTTGGGAGCGCGATCAAGCCTTTTGTGTATCAAATCGCTTTTGATAATGGCTATTCCACGACTTCTAAAATCCCTGATACCGCGCGAAACTTTGAAAATGGCAATTATAGTAAAAACAGCAAACAAAACCATGCATGGCACCCCAGCAATTATTCTCGCAAGTTTTTAGGGCTTGTAACCTTGCAAGAAGCTTTGAGCCATTCATTAAATCTAGCCACGATCAATTTAAGCGATCAGCTTGGCTTTGAAAAAATTTATCAATCTTTAAGCGATATGGGGTTTAAAAACCTCCCTAAAGACTTGTCTATTGTGTTAGGGAGCTTTGCTATCTCACCCATTGAAGCGGCTGAAAAGTATTCTTTATTTTCTAATTACGGCACTATGCTCAAACCCATGCTCATTGAAAGCATCACTAACCAACAAAACGATGTCAAAACTTTCACGCCTATGGAAACCAAAAAGATCACCTCCAAAGAACAGGCTTTTTTAACCATTTCAGTGCTGATGAATGCGGTAGAAAACGGCACAGGGAGTTTGGCTCACATTAAAGGTTTAGAAGTCGCCGGTAAAACCGGAACTTCTAACAACAATATTGACGCTTGGTTCATTGGCTTTACCCCCACCTTGCAAAGCGTGATCTGGTTTGGGAGGGACGATAACACGCCTATTAGCAAAGGAGCGACAGGAGGCGTTGTGAGCGCGCCTGTGTATTCGTATTTCATGCGTAATATTCTAAGCATTGAACCTTCTTTAAAAAGAAAGTTTGATGTCCCCAAAGGCTTGCGTAAAGAAATTGTGGATAAAATCCCCTACTATTCAACCCCCAATTCCATCACCCCCACCCCCAAAAGAACAGACGATAGCGAAGAACGCTTGTTGTTCTAA", "fmax": "2057", "accession": "AF315503.1", "fmin": "77", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori", "NCBI_taxonomy_id": "210", "NCBI_taxonomy_cvterm_id": "36906"}, "protein_sequence": {"accession": "AAK17126.1", "sequence": "MLKKIFYGFIVLFLIIVGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIESLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQLVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEILERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEIAMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNELKSALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYIIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNASNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGNYSKNSKQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIEAAEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPMETKKITSKEQAFLTISVLMNAVENGTGSLAHIKGLEVAGKTGTSNNNIDAWFIGFTPTLQSVIWFGRDDNTPISKGATGGVVSAPVYSYFMRNILSIEPSLKRKFDVPKGLRKEIVDKIPYYSTPNSITPTPKRTDDSEERLLF"}}}}, "model_name": "Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin", "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "40661": {"category_aro_name": "Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics", "category_aro_cvterm_id": "40661", "category_aro_accession": "3003938", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}, "35981": {"category_aro_name": "amoxicillin", "category_aro_cvterm_id": "35981", "category_aro_accession": "0000064", "category_aro_class_name": "Antibiotic", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan."}, "35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35962": {"category_aro_name": "cephamycin", "category_aro_cvterm_id": "35962", "category_aro_accession": "0000044", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases."}}, "ARO_name": "Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "CARD_short_name": "Hpyl_pbp1_AMX", "ARO_id": "45621", "model_type_id": "40293"}, "5739": {"model_id": "5739", "ARO_accession": "3007028", "model_param": {"blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "salD is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins.", "model_sequences": {"sequence": {"8293": {"dna_sequence": {"partial": "0", "sequence": "ATGTCTTTTTATTTTACAGAAAAGCCATTTGAAAGGTTCGGCAAGACATTAATAGAAGAGGTTAATTTAAGTGTTGAACCAGGTGAACATATAGCAATTGTTGGTGATAACGGGGTAGGTAAATCAACATTACTCAATGCAATTTACAATAAATATAATGATTCAACGTATTTGATGGATCAAGAATTATCGAAGTATAAAAATGAAACGGCAATAAATTATATTATGTCGTGGTATCCAGAATTATTAGATATTAAACTTGCTATGCAAACTGATTATGAAAAAATTGGTGACTATATAGAACTTAATGGATATGAAATAGAAGAACAAATCATTTTACAAGCAAAGCAATTAAATTTAGAAGAGTCAGATTTAGATAAACAAATGGGGCAGTTAAGTGGCGGACAACAAACCAAAGTAGCATTAGTTCGAGCAATGATTTCAGAAAAAAATTTAATCTTGTTGGATGAACCAACAAATCACTTAGATAAACAAATGATTCATATTGTCGTGGATTATATAAAGCAAGCAAAGCAAAGTATATTATACGTGTCACATCATAGAGGATTTATCGACGAAACTGCAACGCACATTATTGAAATTACACCACAAGCTACAAGAAAATTTACTGGTAATTATAGTCAATATAAATCCATTATAGATGTTGAAAGAGAAACTCAAAAAAAGGTATACGAGAAAAAGCAAAAAGAAATAAAAGCTTTGGAAGCAACCGTAGATAGAGTTAAAAATTGGCATAAAACTGCGAATCAATCTGCAAGTGTTCGTAATCCGTTAGAGCAAAAGCGTTTGAGTAAATTAGCTCAAAAGGCAAAGGTTAAAGAATCACAAATAAATCAAAAACTTGAAAAGATTAAAGTCCAACAGCCTAAGTCGGATGATCGTCACTTCCATTTTGAGAATCAAGATGCGCTAAATAAAAAATATTTAATGCAATTATATGATTTTAGCATCACTATTGATGGTAAGAATATTTATCAAAATGCAAATTTCGAAATTAAAGATAATGAAAACATTATACTTACTGGCCCGAATGGTAGTGGCAAATCATTATTAATCTCAATTATCAAGCAGTCAATAATACCAGATGAGGGTGATATTTATATAACGCCTTCTCTAAAAATAGCTTATTTTGACCAAAAAAATGACAATTTAAATTATGACAGCACAGCATTAACAATGTTATTAAACATGGAGGGTATGGAACGTAGTCAAGCACAAACGATATTAGCGTCATTTGGATTTGATAACCAAAAAATAAACCTTCCAATTTCTCAATTATCTATGGGAGAGAAAAGTAGATTACAGTTTGTATTATTATATTTCTCAAATCCACATTTATTAATTCTCGACGAACCAACCAATTACTTCGATATTGCTACGCAAGATTTAATATTACAGATGCTAAAGCAATTTGCAGGACAAGTAATGATTGTGACGCATGATGAATACTTGAAATCTCAAATTACAGCGACACATTGGACAATTAAAGATAAAAAGTTAATGAATTTAACATTATCAGAGAAGCATTCACCCAATATGGTGGATGATACATTAAAATTATTAGATGATTATAAGTCGATAGATGAATTCGGACATTTTGAAACAGACAACTAG", "fmax": "254531", "accession": "NZ_JAIEXG010000001.1", "fmin": "252896", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus gallinarum", "NCBI_taxonomy_id": "1293", "NCBI_taxonomy_cvterm_id": "45587"}, "protein_sequence": {"accession": "WP_082039181.1", "sequence": "MSFYFTEKPFERFGKTLIEEVNLSVEPGEHIAIVGDNGVGKSTLLNAIYNKYNDSTYLMDQELSKYKNETAINYIMSWYPELLDIKLAMQTDYEKIGDYIELNGYEIEEQIILQAKQLNLEESDLDKQMGQLSGGQQTKVALVRAMISEKNLILLDEPTNHLDKQMIHIVVDYIKQAKQSILYVSHHRGFIDETATHIIEITPQATRKFTGNYSQYKSIIDVERETQKKVYEKKQKEIKALEATVDRVKNWHKTANQSASVRNPLEQKRLSKLAQKAKVKESQINQKLEKIKVQQPKSDDRHFHFENQDALNKKYLMQLYDFSITIDGKNIYQNANFEIKDNENIILTGPNGSGKSLLISIIKQSIIPDEGDIYITPSLKIAYFDQKNDNLNYDSTALTMLLNMEGMERSQAQTILASFGFDNQKINLPISQLSMGEKSRLQFVLLYFSNPHLLILDEPTNYFDIATQDLILQMLKQFAGQVMIVTHDEYLKSQITATHWTIKDKKLMNLTLSEKHSPNMVDDTLKLLDDYKSIDEFGHFETDN"}}}}, "model_name": "salD", "ARO_category": {"37713": {"category_aro_name": "retapamulin", "category_aro_cvterm_id": "37713", "category_aro_accession": "3001314", "category_aro_class_name": "Antibiotic", "category_aro_description": "Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections."}, "37013": {"category_aro_name": "virginiamycin M1", "category_aro_cvterm_id": "37013", "category_aro_accession": "3000669", "category_aro_class_name": "Antibiotic", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}, "37014": {"category_aro_name": "pleuromutilin antibiotic", "category_aro_cvterm_id": "37014", "category_aro_accession": "3000670", "category_aro_class_name": "Drug Class", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes."}, "37015": {"category_aro_name": "tiamulin", "category_aro_cvterm_id": "37015", "category_aro_accession": "3000671", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "35964": {"category_aro_name": "lincomycin", "category_aro_cvterm_id": "35964", "category_aro_accession": "0000046", "category_aro_class_name": "Antibiotic", "category_aro_description": "Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction."}, "41687": {"category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_cvterm_id": "41687", "category_aro_accession": "3004469", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins."}, "35999": {"category_aro_name": "antibiotic target protection", "category_aro_cvterm_id": "35999", "category_aro_accession": "0001003", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "36218": {"category_aro_name": "oxazolidinone antibiotic", "category_aro_cvterm_id": "36218", "category_aro_accession": "3000079", "category_aro_class_name": "Drug Class", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use."}, "36526": {"category_aro_name": "phenicol antibiotic", "category_aro_cvterm_id": "36526", "category_aro_accession": "3000387", "category_aro_class_name": "Drug Class", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "salD", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "salD", "ARO_id": "45572", "model_type_id": "40292"}, "5738": {"model_id": "5738", "ARO_accession": "3007027", "model_param": {"blastp_bit_score": {"param_value": "400", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "salC is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins.", "model_sequences": {"sequence": {"8292": {"dna_sequence": {"partial": "0", "sequence": "ATGCTATTTTTATTTGAAAAAAAGTCTTTAGAGATTGACAATAAACTGCTCATACCTTCACTAACATTTATTATTGAAGAAAATGAACATTTGGCAATAGTCGGCATAAATGGTATCGGAAAATCTACACTTTTAAATAAAATCCATCATAAAGAAAATATTGAAACAGCAATGATGGAACAAGATTTAACTAAATATGGAACTTTAAATGTCATGGAGTATATTATGTTAACTTATCCACAATTATCATCGTTAAGAGAAAATCTAAGTGATTTGGATAATATAAATAGATATATTGAATTAGACGGTTACGAAATTGAGCAAAACATTATAATTGAAGGAAAAAAGTTAGGATTAACAGAAAGGCACTTTGATCAATTAATTTCTACTTTAAGTGGTGGTGAGCAAACAAAAGTTTCGTTTTTGAAAGTTAAATTAGATAAAGCACGATTATTATTAATTGATGAACCAACTAACCATATGGATGAAGAAATGAAAGTATGGTTAACTAATGCATTTAAACAAGAAAAACGTGCAATATTATTTGTTTCTCACGATAAGACTTTTTTAAATGAAACACCAGACGCAATTTTGGAACTGAGTAGTAGTGGTGCAACAAAATACTCAGGTCAGTATGACAATTACAAGCAACAAAAAGATTTAGAATATAAAACGATTAAGCTACAATACGAAAAACAAGAAAAAGAGCAACGAGCAATTGAAGAAACAATTAAAAAATATAAAGAATGGTATCAAAAAGCTTCACAAAAAGCTTCAGTAAGAAATCCTTATCAACAAAAACAACTTAGCAAGCTTGCGAAAAAGTTTAAATCGAAAGAATATCAAATGAATAAAAAACTTGAACAAACCAATTTATCAGATCCTGAAGAGGAAGGAAAAACATTTTCAATGCAACATCACGCCTTCAAATCTCATTATTTAGTTAAATTTAAAAATGTGACATTTTCATATAATGAAAAGCCTATTTTTAATGATGTCTCTTTTCATATTAAGCGAAATCAAAATGTTATCATTGAAGGTCAAAATGGCTCAGGTAAATCTACTTTGATCAAGTTGATACTAGGTCAACTGACACCTGATGAGGGAGAAGTAATCGTACATCCTGAATTAGAAATAGGTTATTTTTCACAAGATTTTAATAACTTAAATATGAAAAATACTGTGTTAGAAGAAATAATGTCTATTCAAGAAATGAAAGAAGCGGAAGCAAGAACAATTTTAGCGAATTATTATTTTAATGAAAATAGAATTAATGATGTTGTTGCCAATTTATCTATGGGTGAAAAATGTAGAATACAGTTTGTTAAATTGTATTTTTCAAATCCACATATACTCATATTAGATGAGCCAACTAACTATTTTGATATTGAAATGCAAGAAAAAATCATACAATTAATTCAATCTTTTCAAGGATCAACACTTATCATTTCACATGATAAATATTTTAAAGAAAAGCTTAAAGATCAAATTTGGACAATAAAGAATCTAGATTTGGTACATGAAAATCTTAAAATTGAGAATCCATTAAATGCTGATTCTATTAAAAATCAATTAAATGAATTAGAGCAATATACCGACGAAAGAAATAGAGAAACAGAGTTCTAG", "fmax": "117418", "accession": "JAAQPD010000007.1", "fmin": "115792", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mammaliicoccus fleurettii", "NCBI_taxonomy_id": "150056", "NCBI_taxonomy_cvterm_id": "42526"}, "protein_sequence": {"accession": "MBW0764195.1", "sequence": "MLFLFEKKSLEIDNKLLIPSLTFIIEENEHLAIVGINGIGKSTLLNKIHHKENIETAMMEQDLTKYGTLNVMEYIMLTYPQLSSLRENLSDLDNINRYIELDGYEIEQNIIIEGKKLGLTERHFDQLISTLSGGEQTKVSFLKVKLDKARLLLIDEPTNHMDEEMKVWLTNAFKQEKRAILFVSHDKTFLNETPDAILELSSSGATKYSGQYDNYKQQKDLEYKTIKLQYEKQEKEQRAIEETIKKYKEWYQKASQKASVRNPYQQKQLSKLAKKFKSKEYQMNKKLEQTNLSDPEEEGKTFSMQHHAFKSHYLVKFKNVTFSYNEKPIFNDVSFHIKRNQNVIIEGQNGSGKSTLIKLILGQLTPDEGEVIVHPELEIGYFSQDFNNLNMKNTVLEEIMSIQEMKEAEARTILANYYFNENRINDVVANLSMGEKCRIQFVKLYFSNPHILILDEPTNYFDIEMQEKIIQLIQSFQGSTLIISHDKYFKEKLKDQIWTIKNLDLVHENLKIENPLNADSIKNQLNELEQYTDERNRETEF"}}}}, "model_name": "salC", "ARO_category": {"37713": {"category_aro_name": "retapamulin", "category_aro_cvterm_id": "37713", "category_aro_accession": "3001314", "category_aro_class_name": "Antibiotic", "category_aro_description": "Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections."}, "37013": {"category_aro_name": "virginiamycin M1", "category_aro_cvterm_id": "37013", "category_aro_accession": "3000669", "category_aro_class_name": "Antibiotic", "category_aro_description": "Virginiamycin M1 is a streptogramin A antibiotic."}, "37014": {"category_aro_name": "pleuromutilin antibiotic", "category_aro_cvterm_id": "37014", "category_aro_accession": "3000670", "category_aro_class_name": "Drug Class", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes."}, "37015": {"category_aro_name": "tiamulin", "category_aro_cvterm_id": "37015", "category_aro_accession": "3000671", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "35964": {"category_aro_name": "lincomycin", "category_aro_cvterm_id": "35964", "category_aro_accession": "0000046", "category_aro_class_name": "Antibiotic", "category_aro_description": "Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction."}, "41687": {"category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_cvterm_id": "41687", "category_aro_accession": "3004469", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins."}, "35999": {"category_aro_name": "antibiotic target protection", "category_aro_cvterm_id": "35999", "category_aro_accession": "0001003", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance."}, "35945": {"category_aro_name": "streptogramin antibiotic", "category_aro_cvterm_id": "35945", "category_aro_accession": "0000026", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30."}, "36189": {"category_aro_name": "tetracycline antibiotic", "category_aro_cvterm_id": "36189", "category_aro_accession": "3000050", "category_aro_class_name": "Drug Class", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes."}, "36218": {"category_aro_name": "oxazolidinone antibiotic", "category_aro_cvterm_id": "36218", "category_aro_accession": "3000079", "category_aro_class_name": "Drug Class", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use."}, "35983": {"category_aro_name": "clindamycin", "category_aro_cvterm_id": "35983", "category_aro_accession": "0000066", "category_aro_class_name": "Antibiotic", "category_aro_description": "Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria."}, "36526": {"category_aro_name": "phenicol antibiotic", "category_aro_cvterm_id": "36526", "category_aro_accession": "3000387", "category_aro_class_name": "Drug Class", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome."}, "35936": {"category_aro_name": "lincosamide antibiotic", "category_aro_cvterm_id": "35936", "category_aro_accession": "0000017", "category_aro_class_name": "Drug Class", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides."}}, "ARO_name": "salC", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "salC", "ARO_id": "45571", "model_type_id": "40292"}, "5734": {"model_id": "5734", "ARO_accession": "3007021", "model_param": {"blastp_bit_score": {"param_value": "515", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "BioF is a class B2 metallo-beta-lactamase first identified in Pseudomonas. It belongs to the PFM-like beta-lactamase gene family. It confers resistance to carbapenems and some cephalosporins.", "model_sequences": {"sequence": {"8131": {"dna_sequence": {"partial": "0", "sequence": "ATGAAGCTTATTAATATTCTGTCAGTCATCAGCCTGGCCTGCATTACCTCCCAGGTCTTCGCTAACAAGAGTGACTTGACCCTTACCCACTTCAAAGGCCCGCTCTACATCGTTGAAGACAAGGAATATGTGCAGGAGAACTCAATGGTCTACGTTGGCGAGCAACACATCACGGTTATTGGCGCAACCTGGACCCCAGCCACCGCTGAAAAGCTTGAGCAGGAAATCAGGAAAATCAGCCCCCTGCCCATCAAGGAGGTGATCAATACCAACTACCACACCGACCGCGCGGGAGGTAACGCCTACTGGAAGAAGCTCGGCGCCAGTATTGTCTCAACGCAGATGACCTATGACCTGGAAAAAAGCCAGTGGCGCAGTATTGTCGACTTTACCCGGCAAGGGATGGAGCACTATCCAATCCTGGAACAAAGCCTGCCAGACCAGGTATACCCGGGCAACTTCGACTTGCAAAACGGCCATGTTAGAGCACTGTATTTAGGCGCGTCTCACACCGAAGATGGGATTTTTGTGTACTTTCCAGAAGAGCGTGTGTTGTATGGAAACTGCATTCTCAAGGAAAAGCTGGGTAACATGACATTCGCGAATCGCAGCGAGTACCCGAAAACCCTGAAGAAATTGCAAGGGCTGATCCGCAGTGGTGAATTGCCCGTTGAAGCGATTATCGCAGGGCATAACTCACCGATACAGAACGTTGAGTTGATTGACCATTATCTGACCCTGCTTGAACACGGCGAGCAGTAA", "fmax": "5396", "accession": "JACOMR010000005.1", "fmin": "4634", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas sp. BF61", "NCBI_taxonomy_id": "2741068", "NCBI_taxonomy_cvterm_id": "45494"}, "protein_sequence": {"accession": "MBU4627809.1", "sequence": "MKLINILSVISLACITSQVFANKSDLTLTHFKGPLYIVEDKEYVQENSMVYVGEQHITVIGATWTPATAEKLEQEIRKISPLPIKEVINTNYHTDRAGGNAYWKKLGASIVSTQMTYDLEKSQWRSIVDFTRQGMEHYPILEQSLPDQVYPGNFDLQNGHVRALYLGASHTEDGIFVYFPEERVLYGNCILKEKLGNMTFANRSEYPKTLKKLQGLIRSGELPVEAIIAGHNSPIQNVELIDHYLTLLEHGEQ"}}}}, "model_name": "BioF", "ARO_category": {"45491": {"category_aro_name": "PFM-like beta-lactamase", "category_aro_cvterm_id": "45491", "category_aro_accession": "3007020", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "PFM-like beta-lactamases are class B2 beta-lactamase enzymes found in Pseudomonas species."}, "35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}}, "ARO_name": "BioF", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "BioF", "ARO_id": "45492", "model_type_id": "40292"}, "5751": {"model_id": "5751", "ARO_accession": "3001745", "model_param": {"blastp_bit_score": {"param_value": "530", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "OXA-290 is a beta-lactamase found in Acinetobacter spp.", "model_sequences": {"sequence": {"8312": {"dna_sequence": {"partial": "1", "sequence": "ATGCCAAAAATACTAAAACATCTTAGCCTTTGCGCATCTGTAATGATTGGACTGACGTTGCTAGGTTGCCAAAATTTGCACGCCCCAACTCAAAGCGCCGTGTCAAAAAAACACGATCAAACCGAGATCGCTTCTTTATTCCAACATACTCAAACTGTTGGCGTATTTGTTACATATGATGGGCAAACATTTCAAGAATATGGCAATGCGTTGAGTCGATCGAATACGGCTTATATTCCAGCCTCAACCTTCAAGATGTTAAATGCTCTGATTGGGATACAGCATCACAAAAGTTCGCCCAACGAAGTGTTTAAATGGGATGGCAAAAAGCGTGCTTTTGCGAGCTGGGAAAAAGATTTAACTTTAGCCGAGGCGATGCAGGCATCAGCAGTGCCTGTTTATCAGGAATTGGCTCGGCGTATCGGGTTAGAGTTGATGGCGAACGAAGTAAAACGCGTTGGCTTTGGCAATACTGAGATCGGAACGCAAGTCGATGATTTTTGGTTGGTTGGCCCGCTTAAGATTACCCCCGTTGACGAAGTGAAATTTGCTTATGCTCTGGCAAATAAGCAGCTTGCATTTGACCAATCTGTGCAAGAACAAGTGAAACAGATGGTCTTCGTTGATGAAGTTCATGGAACTAAGATTTATGCCAAAAGTGGTTGGGGTATGGATGTAACACCGCAAGTGGGTTGGTGGACGGGCTGGATTGAACAACCGAATGGACAGGTGATTGCATTTGCTTTAAATCTGGAAATAAATAAGCCTGAGCACGGTGATGCGCGTAAAGCGATTGTTTATCAAGCATTACAACAATTGAAATTGTTACAGAAGCAATAAATATTTTCTTAAAAAAAGCCCAACTTTAACGAAAAAGTTGGGCTTGGAAATAGGATGTTTATACTTGGGGGAGAAAACATCCTAGAGGGTTAAAAGTACAGATTCAGGTATTGCTTGGCTTGATTAAATTATGTGCAAATGATCTTGATTTGTAAAATTGATAATTTTCATATTTAGAATCTATTTATCCAATAGTCTTGCTGCTAGGTGATTTGATCAATGATATTGAGGAAATTGAAAAGTTGCTGTGGTTGAGAGAACACAGGTAAAATTATTGATTGTTTAAAAATTAATCTGGATGGCTTTTTGAGAAAGACAAGGTGGGTTTATGGGACGTAACTTAAGACGTGTTAAATTACGTTCAGAACAAATCAGCCTTCGACTTTTTGTCTGTATGGCGATCATTATCTTATCAATTCTATATATTTCTATTCCTTTAATTCTGAATAGTTTTCAAGAATATAATAAAACAAATCAGGTTTTGACTGAAATCACCAGCTTACGTGCATTAGTCCAAACTGCAAATAAGATTTCTAGAGAGCGCGGACCTGCAAATAAGGTTATGTCGAGTACATTAGAAGACATAGAAAAAAATAAACAGGAATTGTCTGAGTTTAGATTGGTTGTTGATAAGCAGATTAATGAAACAGTATCGACTTTAAATCAAGCGGGTTTCACATCAGTCGCAGCACAGCTCCAAACTGATTTGAAATTAAAATTAGAGCAGGCGCGTAAAATCGTCGACGCATATGCGGAAATACCACAGTCTCAACGCACATCTCAGCAACTTGATCATGCCATTTTAACCATGTTCAGTGTTTGGGATAACAGCCGTGAGCTTCTCAATGAGTTGATGGCGCAGTCGAAAAGTAAAGACAGTAAGATGTCGAATTATTTTATTTCTATTTTGATTCTAACGGATATGCGTGATCAGGCAGGACGAGTTGCATCTAATGTTATGGCACCGATTACTTTTTCTGAAAAAATTTCTGATATAAACCGTGCGAGGACTTTGCAAACAGAGCATCAGGCTAAATATCTGTGGTCCTTGGTCGATATAATTCAACCGCAATATATGAAAACTTCTGATTACATTCGATTACACCTACGTGTAAGAACGGAGTTCTTAGAACAAGGATTACCTATCATCCGTAGATTGTTAGATGAAAGTCAAAATAATCAAGCGTATTTTTTAACAGGGACGCAACTGACAGAACAAATTGTTGATAAATACACCACAGTCATGGATCTACAAAAGTATATTTTAGATTACAGTGTCCATATCGCAACGCAACAGAATAAAAAGGCCAAACAACAGTATTTTTTTACTCTAGCGATTTCAAGCTTATCACTGTTGATTGCTTTTTTTACGATGATCTATACCAAGAGAAAGGTATTTAGCCCTTTGATTAAAGCACGTGAGATGATTTTGGGTTTATCGGATACGATGCATGGGCCACCTTCTCGTCAGAAATCAAAACATGAGTTTTACTCCTTGTTTGAAGCAATTGATAAATTAAAACTAATGCTTAAGCAGCGCGATTTGATGGAGTCACAACTCAAGCAAATTGCGAATTCTGATGTATTAACGGGTGTATCAAATCGGTTGGCATTAGAAGAATATATTAATGATTTGACGGCTAAGCCGAATGCGCTATCTCAGACATGTGTGTTTGCAATCGATATTGATCATTTTAAGTATGTAAATGATCAATATGGGCATCTTGTTGGTGATGAAGTGATTGCAATGGTTGCCAATCAACTCAAGCATTATGTACGTGCTTCTGATCTTATCGTGCGTTATGGTGGTGATGAATTCTTGGTCGTGATCGAGAGTATTCAAATGGATGCCGCTATGGCGATTGCGGAAAGTATTCGCTTAGGGATTGCTACGCAAAGTATCGCTGTTACAAGTTTGGGGAAGTCGATTCAGGTTTCTGTCAGTATAGGAGTGGCTATCGGTGCAGAGAGTTGGTTAGAACTCTTAGAAAAAGCGGATCAATCGTTGTTAAAAGCGAAAGCCAGAGGTAAGAATGTAGTGGAGGGTTGA", "fmax": "290778", "accession": "APOK01000044.1", "fmin": "287888", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter sp. CIP-A165", "NCBI_taxonomy_id": "40373", "NCBI_taxonomy_cvterm_id": "39511"}, "protein_sequence": {"accession": "WP_081398973.1", "sequence": "MPKILKHLSLCASVMIGLTLLGCQNLHAPTQSAVSKKHDQTEIASLFQHTQTVGVFVTYDGQTFQEYGNALSRSNTAYIPASTFKMLNALIGIQHHKSSPNEVFKWDGKKRAFASWEKDLTLAEAMQASAVPVYQELARRIGLELMANEVKRVGFGNTEIGTQVDDFWLVGPLKITPVDEVKFAYALANKQLAFDQSVQEQVKQMVFVDEVHGTKIYAKSGWGMDVTPQVGWWTGWIEQPNGQVIAFALNLEINKPEHGDARKAIVYQALQQLKLLQKQ"}}}}, "model_name": "OXA-290", "ARO_category": {"35939": {"category_aro_name": "carbapenem", "category_aro_cvterm_id": "35939", "category_aro_accession": "0000020", "category_aro_class_name": "Drug Class", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "36026": {"category_aro_name": "OXA beta-lactamase", "category_aro_cvterm_id": "36026", "category_aro_accession": "3000017", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime."}}, "ARO_name": "OXA-290", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "OXA-290", "ARO_id": "38145", "model_type_id": "40292"}, "5750": {"model_id": "5750", "ARO_accession": "3007051", "model_param": {"blastp_bit_score": {"param_value": "3000", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}, "snp": {"param_type": "single resistance variant", "param_value": {"12333": "Q2079K", "12307": "Q527K", "12316": "D530L", "12317": "D530F", "12314": "D530I", "12315": "D530Y", "12312": "I586L", "12339": "V149E", "12310": "S545L", "12311": "I586N", "12338": "V149K", "12336": "V149F", "12337": "V149Q", "12331": "A2414T", "12332": "K2068R", "12313": "D530G", "12324": "V2592L", "12319": "H540N", "12326": "F2538L", "12383": "A2414V", "12323": "I2619V", "12322": "D530E", "12321": "D530N", "12306": "L525P", "12327": "I837V", "12318": "H540Y", "12325": "T2537A", "12320": "L525I", "12341": "V149W", "12340": "V149D", "12342": "R701H", "12309": "D530V", "12308": "Q527R"}, "clinical": {"12333": "Q2079K", "12307": "Q527K", "12316": "D530L", "12317": "D530F", "12314": "D530I", "12315": "D530Y", "12312": "I586L", "12339": "V149E", "12310": "S545L", "12311": "I586N", "12338": "V149K", "12336": "V149F", "12337": "V149Q", "12331": "A2414T", "12332": "K2068R", "12313": "D530G", "12324": "V2592L", "12319": "H540N", "12326": "F2538L", "12383": "A2414V", "12323": "I2619V", "12322": "D530E", "12321": "D530N", "12306": "L525P", "12327": "I837V", "12318": "H540Y", "12325": "T2537A", "12320": "L525I", "12341": "V149W", "12340": "V149D", "12342": "R701H", "12309": "D530V", "12308": "Q527R"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}, "40330": {"param_value": {"12335": "V148I, V149F"}, "param_type_id": "40330", "param_type": "multiple resistance variants", "param_description": "A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms."}}, "ARO_description": "Rifampicin inhibits transcription by binding the beta subunit of RNA polymerase. Helicobacter pylori mutations associated with rifampicin resistance typically occur in the rifampicin resistance determining region of rpoB between codons 525 and 586.", "model_sequences": {"sequence": {"8304": {"dna_sequence": {"partial": "0", "sequence": "ATGTCAAAAAAAATTCCCCTAAAAAACCGCTTGAGAGCTGATTTTACAAAAACCCCAACAGATTTAGAAGTCCCTAATTTATTATTATTACAACGAGACAGCTATGATTCTTTCTTGTATTCTAAAGAGGGTAAAGAGAGCGGGATTGAAAAGGTTTTTAAATCCATTTTCCCTATCCAAGATGAGCATAACCGCATCACTTTAGAATACGCGGGTTGCGAATTTGGCAAGTCTAAATACACCGTTAGAGAAGCGATGGAGAGGGGCATTACCTACTCTATCCCTCTCAAAATTAAGGTGCGCTTGATCTTGTGGGAAAAAGATACCAAGAGTGGCGAAAAGAACGGCATTAAGGATATTAAAGAACAAAGCATTTTCATTCGTGAGATCCCTTTGATGACAGAACGCACTTCATTTATTATTAATGGGGTGGAGCGCGTGGTGGTCAATCAACTCCACAGAAGCCCCGGTGTGATTTTCAAAGAAGAAGAGTCTAGCACTTCTTTAAACAAGCTCATTTACACAGGGCAAATCATTCCTGATAGGGGTTCGTGGTTGTATTTTGAATACGATTCTAAAGATGTTTTATACGCTCGTATCAATAAACGCCGTAAAGTGCCTGTTACCATTTTATTCAGGGCGATGGATTATCAAAAACAAGACATCATCAAAATGTTCTACCCGCTTGTTAAAGTGCGTTATGAAAACGATAAATATTTGATCCCGTTTGCTTCATTAGACGCCAATCAAAGAATGGAATTTGACTTGAAAGATCCTCAAGGCAAGGTTATTCTTTTAGCGGGTAAAAAGCTCACTTCAAGAAAGATTAAAGAGCTTAAAGAAAACCATTTAGAATGGGTGGAATACCCTATGGATATTTTACTCAATCGCCATTTAGCTGAGCCTGTTATGGTAGGGAAAGAAGTCTTATTGGACATGCTCACTCAGCTAGATAAAAACAAATTAGAAAAAATCCACGATTTAGGCGTGCAAGAATTTGTGATCATCAACGATCTGGCGTTAGGGCATGACGCTTCCATTATCCAATCTTTTTCAGCCGATTCTGAGTCTTTGAAATTACTCAAGCAAACCGAAAAAATTGATGATGAAAACGCTCTAGCGGCGATTCGTATCCATAAGGTTATGAAACCAGGCGATCCCGTTACGACTGAAGTGGCTAAGCAGTTTGTCAAAAAACTTTTCTTTGATCCAGAACGCTATGATTTGACCATGGTGGGCCGCATGAAAATGAATCACAAGTTAGGCTTGCATGTGCCTGATTACATTACGACTTTAACGCATGAAGATATTATCACCACCGTTAAATACCTCATGAAGATCAAAAACAATCAAGGCAAGATTGATGACAGGGACCACTTGGGCAATCGTAGGATTAGGGCGGTAGGGGAATTGTTGGCCAATGAATTGCATTCAGGTTTAGTGAAAATGCAAAAGACCATTAAAGACAAGCTCACTACCATGAGCGGGGCTTTTGATTCGCTCATGCCCCATGACTTGGTCAATTCTAAAATGATCACAAGCACCATCATGGAATTTTTCATGGGCGGTCAGCTCTCGCAATTTATGGATCAAACGAATCCCTTGAGTGAGGTTACGCACAAGCGCCGCCTTTCAGCGCTCGGCGAAGGGGGGTTGGTGAAAGACAGAGTGGGGTTTGAAGCCAGGGATGTGCACCCCACGCATTATGGCCGAATTTGTCCCATTGAGACCCCAGAAGGTCAAAATATCGGTCTGATCAACACCCTTTCCACTTTCACAAGAGTGAATGATTTAGGCTTTATTGAAGCCCCTTATAAAAAGGTTGTGGATGGCAAGGTCGTGGGTGAGACGATTTATTTGACCGCTATTCAAGAAGACAGCCACATCATCGCTCCCGCAAGCACCCCCATTGATGAAGAGGGGAATATTTTGGGCGATTTGATTGAAACGCGCGTGGAAGGCGAGATCGTTTTAAACGAAAAAAGCAAAGTAACCTTAATGGATTTAAGCTCTAGCATGCTAGTGGGGGTAGCCGCATCGCTCATTCCTTTCTTAGAGCATGATGACGCCAACCGTGCCTTAATGGGGACTAACATGCAGCGCCAAGCGGTGCCCTTATTAAGAAGCGACGCTCCCATTGTAGGCACGGGGATTGAAAAAATTATTGCTAGGGATTCTTGGGGAGCGATCAAAGCCAATCGCGCAGGCGTTGTAGAAAAAATTGATTCTAAAAATATTTATATTTTAGGCGAAAGCAAAGAAGAAGCCTATATTGATGCGTATTCTTTGCAAAAAAACTTGCGCACCAACCAAAACACCAGTTTCAATCAAGTCCCTATCGTTAAAGTGGGCGATAAAGTGGGAGCCGGGCAAATCATCGCTGATGGCCCTAGCATGGATAGAGGCGAGTTGGCGTTAGGGAAAAATGTGCGCGTGGCGTTCATGCCTTGGAATGGCTATAACTTTGAAGACGCGATCGTGGTGAGTGAGTGCATCACTAAAGATGATATTTTCACTTCCACCCACATTTATGAAAAAGAAGTGGATGCTAGGGAGCTTAAGCATGGTGTGGAAGAATTTACCGCTGATATTCCTGATGTGAAAGAAGAAGCGCTCGCTCATCTTGATGAAAGCGGGATCGTTAAAGTCGGTACTTATGTGAGCGCTGGCATGATTTTGGTGGGCAAAACTTCTCCTAAAGGCGAGATTAAAAGCACGCCTGAAGAGCGGCTTTTAAGGGCTATTTTTGGGGATAAAGCCGGGCATGTGGTCAATAAGAGTTTGTATTGCCCTCCCAGTTTGGAAGGCACGGTGATTGATGTGAAAGTCTTCACTAAAAAAGGCTATGAGAAAGACGCGCGAGTTTTGAGCGCGTATGAAGAAGAAAAAGCCAAGCTTGATATGGAGCATTTTGATCGCTTGACCATGCTCAATAGAGAAGAATTGTTGCGCGTTAGCTCGCTCCTTTCTCAAGCGATTTTAGAAGAGCCTTTCAGCCATAACGGCAAGGATTATAAAGAAGGCGATCAAATCCCTAAAGAAGAAATCGCTTCAATCAACCGCTTCACTTTGGCTAGTTTGGTCAAAAAGTATTCTAAAGAAGTGCAAAACCACTATGAAATCACTAAAAACAATTTCTTAGAGCAAAAGAAAGTTTTGGGCGAAGAGCATGAAGAAAAGCTTTCTATTTTAGAAAAAGATGATATTTTGCCTAATGGCGTGATCAAAAAAGTCAAGCTCTATATCGCTACAAAACGAAAGCTTAAAGTGGGCGATAAAATGGCAGGAAGGCATGGGAATAAAGGGATTGTGTCTAATATCGTGCCGGTTGCGGATATGCCTTATACCGCTGATGGCGAGCCTGTAGATATTGTTTTAAACCCTTTAGGCGTGCCAAGCCGCATGAATATCGGGCAGATTTTAGAAATGCATTTAGGCTTAGTGGGGAAAGAATTTGGGAAGCAAATCGCTCGCATGCTAGAGGATAAAACCAAAGATTTTGCCAAAGAATTGCGTGCTAAAATGCTAGAAATCGCTAACGCTATTAATGAAAAAGACCCCTTGACAATCCATGCGCTTGAGAATTGTTCTGATGAAGAGCTTTTGGAATACGCAAAAGATTGGAGCAAGGGCGTTAAGATGGCTATCCCTGTGTTTGAAGGCATCTCGCAAGAAAAATTTTATAAGCTATTTGAATTAGCTAAGATCGCTATGGATGGCAAAATGGATCTGTATGACGGACGCACAGGCGAGAAAATGAGGGAGCGCGTGAATGTGGGCTACATGTATATGATCAAACTCCACCATTTAGTGGATGAAAAAGTCCATGCCAGAAGCACAGGCCCTTATAGCTTAGTAACGCACCAGCCCGTGGGGGGTAAAGCGCTCTTTGGGGGTCAAAGGTTTGGGGAAATGGAAGTGTGGGCCTTGGAAGCTTATGGCGCAGCGCACACTCTAAAAGAAATGCTCACCATTAAATCCGATGATATTAGAGGCAGAGAGAACGCTTATAGGGCTATCGCTAAAGGTGAGCAAGTGGGCGAGAGTGAAATCCCTGAGACTTTCTATGTTTTGACTAAAGAATTGCAATCGCTCGCTTTGGATATTAATATTTTTGGGGACGATGTGGATGAGGATGGAGCACCTAAACCCATTGTCATTAAAGAAGATGACAGGCCTAAAGACTTTAGCTCTTTCCAGCTCACACTAGCTAGCCCTGAAAAAATCCATTCTTGGAGTTATGGGGAAGTTAAAAAGCCAGAAACGATCAATTATCGCACCCTAAAACCTGAACGAGACGGCTTGTTTTGCATGAAAATCTTTGGCCCCACTAAAGATTATGAATGCTTGTGCGGCAAATACAAAAAGCCTCGCTTCAAAGACATTGGCACATGCGAAAAATGCGGCGTGGCGATCACGCACTCCAAAGTCAGGCGTTTTAGAATGGGGCATATTGAATTGGCCACTCCTGTAGCGCATATCTGGTATGTTAATTCCTTGCCTAGCCGTATCGGCACGCTTTTAGGCGTTAAGATGAAAGACTTAGAGCGCGTGTTGTATTATGAAGCTTATATCGTTAAAGAACCAGGCGAAGCCGCTTATGACAATGAAGGCACTAAGCTTGTGATGAAATACGATATTTTGAATGAAGAGCAGTATCAAAATATCTCACGAAGATACGAAGACAGGGGCTTTGTAGCGCAAATGGGCGGTGAAGCGATCAAGGATTTGTTAGAAGAAATTGATTTGATCACCTTATTGCAGAGTTTGAAAGAAGAAGTGAAAGACACCAATTCTGATGCGAAAAAGAAAAAACTCATTAAGCGTTTGAAAGTGGTAGAAAGCTTTTTAAATTCTGGTAATAGGCCTGAATGGATGATGCTCACGGTTTTACCGGTATTGCCACCGGATTTAAGGCCTTTAGTCGCGCTAGATGGCGGGAAGTTTGCAGTCAGCGATGTGAATGAATTGTATCGTCGTGTCATCAATCGTAACCAACGCTTGAAACGCTTAATGGAGCTTGGAGCGCCAGAAATCATTGTGCGCAATGAAAAAAGGATGTTGCAAGAAGCCGTGGATGTGCTTTTTGATAACGGCCGCAGCACTAATGCGGTTAAAGGGGCTAACAAACGCCCTTTAAAATCGCTCAGTGAAATCATTAAAGGCAAGCAGGGGCGTTTCAGGCAAAACCTTTTAGGTAAGCGCGTGGATTTTTCAGGCAGAAGCGTGATTGTGGTTGGGCCTAATCTCAAAATGGATGAATGCGGGTTGCCTAAAAACATGGCGTTAGAACTCTTCAAACCGCATTTGTTATCCAAGCTTGAAGAGAGAGGCTATGCCACCACGCTCAAACAGGCTAAACGCATGATTGAGCAAAAAAGCAATGAAGTATGGGAGTGCTTGCAAGAAATCACAGAGGGGTATCCGGTGCTACTCAACCGCGCTCCTACCTTGCACAAGCAATCCATTCAAGCGTTCCATCCAAAGCTGATTGACGGCAAAGCGATCCAATTGCACCCGTTAGTGTGTTCAGCGTTCAACGCCGATTTTGACGGGGACCAAATGGCGGTGCATGTGCCTTTAAGCCAGGAAGCGATCGCTGAATGCAAGGTGCTGATGCTAAGCTCTATGAATATCCTTTTGCCTGCTAGCGGTAAGGCCGTAGCCATTCCTAGCCAAGATATGGTTTTAGGGCTTTATTATCTTTCTTTAGAAAAGAGCGGGGTCAAGGGCGAGCATAAGCTTTTTTCTAGCGTGAATGAAATCATCACCGCCATTGACACGAAAGAATTAGACATCCACGCAAAGATTAGGGTTTTAGATCAAGGGAATATTATCGCTACGAGTGCAGGGCGCATGATCATTAAGTCCATTTTGCCTGATTTTATCCCTACGGATTTGTGGAACAGACCCATGAAGAAAAAAGATATTGGCGTGCTTGTGGATTATGTGCATAAAGTTGGCGGTATCGGTATTACTGCAACCTTTTTGGATAATTTAAAAACGCTTGGCTTTAGGTATGCGACTAAGGCTGGTATTTCTATCTCTATGGAGGATATTATCACGCCAAAAGACAAGCAAAAAATGGTGGAAAAAGCCAAAGTAGAGGTTAAAAAAATCCAGCAACAATACGATCAAGGGCTGCTCACTGACCAAGAGCGTTACAATAAGATCATTGACACTTGGACTGAAGTCAATGACAAAATGAGTAAAGAAATGATGACCGCTATCGCGCAAGATAAAGAGGGCTTTAACTCTATTTATATGATGGCAGATAGCGGCGCAAGGGGTAGCGCGGCGCAAATCCGTCAGCTTTCAGCGATGAGGGGTCTTATGACAAAGCCGGACGGCAGTATCATTGAAACGCCCATTATTTCTAACTTTAAAGAGGGGTTGAATGTCTTAGAATACTTCAATTCCACGCATGGCGCTAGAAAGGGCTTAGCGGATACAGCGCTAAAAACAGCCAATGCGGGGTATTTGACCAGAAAGCTCATTGATGTTTCGCAAAATGTCAAGGTGGTGTCTGATGATTGCGGCACGCATGAAGGGATTGAAATCACGGATATTGCGGTGGGGAGTGAGCTGATTGAACCTTTAGAAGAGCGTATTTTTGGGCGCGTTTTATTAGAAGATGTGATCGATCCCATTACGAATGAAATCTTGCTTTATGCGGACACTTTGATTGATGAAGAGGGTGCTAAAAAGGTGGTTGAAGCCGGGATTAAATCCATTACGATCCGCACCCCAGTAACTTGTAAAGCGCCAAAGGGCGTGTGCGCGAAATGCTATGGCTTGAATTTGGGCGAAGGCAAGATGAGTTATCCGGGTGAAGCGGTGGGCGTGGTAGCCGCGCAATCTATTGGGGAGCCTGGAACGCAGCTCACTTTAAGGACTTTCCATGTGGGCGGGACAGCGAGCAGGAGTCAGGATGAGCGCGAAATCGTAGCGAGCAAAGAAGGTTTTGTGCGTTTTTACAACCTTAGGACTTACACGAATAAAGAGGGTAAAAACATTATCGCTAACCGCCGTAACGCTTCTATTTTAGTGGTAGAGCCTAAGATTAAAGCGCCTTTTGATGGGGAATTACGCATTGAAACGGTTTATGAAGAAGTCGTTGTGAGCGTGAAAAATGGCGATCAAGAAGCTAAATTTGTTTTAAGGAGAAGCGATATTGTCAAGCCAAGCGAATTAGCCGGCGTTGGCGGTAAGATTGAGGGGAAAGTGTATTTGCCTTATGCTAGTGGGCATAAGGTGCATAAGGGGGGAAGTATCGCTGATATTATCCAAGAGGGCTGGAATGTGCCTAATCGCATCCCTTATGCGAGCGAATTGCTAGTCAAGGATAATGACCCTATTGCGCAAGATGTGTATGCCAAAGAAAAAGGCGTAATCAAATACTATGTTTTAGAGGCTAACCATTTAGAGCGCACCCATGGGATCAAAAAGGGCGATATGGTGAGTGAAAAAGGCTTGTTTGCGGTGATAGCTGATGATAATGGTAGGGAAGCCGCTCGCCATTATATCGCTAGGGGTTCTGAGATCTTGATTGATGATAATAGTGAAGTGAGCACTAATAGCGTGATTTCTAAACCCACGACTAACACTTTCAAAACGATTGCCACATGGGATCCTTACAACACCCCTATCATTGCGGACTTTAAAGGTAAGGTGGGTTTTGTGGATGTTATCGCAGGGGTTACGGTCGCTGAAAAAGAAGACGAAAATACCGGTATCACAAGCTTAGTGGTGAATGATTACATTCCAAGCGGATACAAACCAAGCTTGTTTTTAGAGGGGGCTAATGGCGAAGAGATGCGTTATTTCCTAGAGCCAAAAACCTCTATCGCCATTAGCGATGGCTCTAGCGTGGAGCAAGCTGAAGTGTTAGCGAAAATCCCTAAAGCGACCGTTAAATCTAGGGATATTACCGGGGGTCTCCCAAGGGTTTCGGAACTCTTTGAAGCGAGAAAACCCAAGCCTAAAGATGTGGCGATCCTTTCTGAAGTTGATGGGATTGTGAGTTTTGGCAAACCCATTCGCAATAAAGAACACATCATCGTAACTTCTAAAGATGGCCGTTCCATGGATTATTTTGTGGATAAAGGCAAGCAAATTTTAGTGCATGCCGATGAATTTGTGCATGCGGGAGAAGCGATGACGGACGGAGTAATTTCAAGCCATGATATTTTAAGGATCAGTGGCGAAAAAGAGCTTTATAAATACATTGTGAGCGAAGTCCAGCAAGTGTATCGCAGGCAGGGGGTGAGCATTGCGGACAAGCACATTGAAATCATTGTTTCTCAAATGCTAAGACAGGTGCGTATTTTAGACAGCGGGGATAGCAAGTTTATTGAAGGGGATTTAGTCAGTAAAAAACTTTTCAAAGAAGAAAACGCTCGTGTGATCGCTTTAAAAGGCGAGCCAGCGATTGCTGAACCGGTGCTTTTAGGGATCACTAGAGCGGCTATTGGGAGCGATAGCATCATCTCAGCGGCCTCTTTCCAAGAAACGACTAAAGTTTTAACAGAAGCCAGTATCGCTATGAAAAAAGACTTTTTAGAGGATTTGAAAGAGAATGTGGTGTTGGGGAGGATGATCCCTGTGGGAACAGGCATGTATAAGAATAAAAAAATCGTGTTAAGAGCGCTTGAGGATAACTCTAAATTTTGA", "fmax": "1277049", "accession": "AE000511.1", "fmin": "1268376", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori 26695", "NCBI_taxonomy_id": "85962", "NCBI_taxonomy_cvterm_id": "36758"}, "protein_sequence": {"accession": "AAD08242.1", "sequence": "MSKKIPLKNRLRADFTKTPTDLEVPNLLLLQRDSYDSFLYSKEGKESGIEKVFKSIFPIQDEHNRITLEYAGCEFGKSKYTVREAMERGITYSIPLKIKVRLILWEKDTKSGEKNGIKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPGVIFKEEESSTSLNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQKQDIIKMFYPLVKVRYENDKYLIPFASLDANQRMEFDLKDPQGKVILLAGKKLTSRKIKELKENHLEWVEYPMDILLNRHLAEPVMVGKEVLLDMLTQLDKNKLEKIHDLGVQEFVIINDLALGHDASIIQSFSADSESLKLLKQTEKIDDENALAAIRIHKVMKPGDPVTTEVAKQFVKKLFFDPERYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIRAVGELLANELHSGLVKMQKTIKDKLTTMSGAFDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKDRVGFEARDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVVGETIYLTAIQEDSHIIAPASTPIDEEGNILGDLIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIVGTGIEKIIARDSWGAIKANRAGVVEKIDSKNIYILGESKEEAYIDAYSLQKNLRTNQNTSFNQVPIVKVGDKVGAGQIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSECITKDDIFTSTHIYEKEVDARELKHGVEEFTADIPDVKEEALAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKVFTKKGYEKDARVLSAYEEEKAKLDMEHFDRLTMLNREELLRVSSLLSQAILEEPFSHNGKDYKEGDQIPKEEIASINRFTLASLVKKYSKEVQNHYEITKNNFLEQKKVLGEEHEEKLSILEKDDILPNGVIKKVKLYIATKRKLKVGDKMAGRHGNKGIVSNIVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIARMLEDKTKDFAKELRAKMLEIANAINEKDPLTIHALENCSDEELLEYAKDWSKGVKMAIPVFEGISQEKFYKLFELAKIAMDGKMDLYDGRTGEKMRERVNVGYMYMIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIAKGEQVGESEIPETFYVLTKELQSLALDINIFGDDVDEDGAPKPIVIKEDDRPKDFSSFQLTLASPEKIHSWSYGEVKKPETINYRTLKPERDGLFCMKIFGPTKDYECLCGKYKKPRFKDIGTCEKCGVAITHSKVRRFRMGHIELATPVAHIWYVNSLPSRIGTLLGVKMKDLERVLYYEAYIVKEPGEAAYDNEGTKLVMKYDILNEEQYQNISRRYEDRGFVAQMGGEAIKDLLEEIDLITLLQSLKEEVKDTNSDAKKKKLIKRLKVVESFLNSGNRPEWMMLTVLPVLPPDLRPLVALDGGKFAVSDVNELYRRVINRNQRLKRLMELGAPEIIVRNEKRMLQEAVDVLFDNGRSTNAVKGANKRPLKSLSEIIKGKQGRFRQNLLGKRVDFSGRSVIVVGPNLKMDECGLPKNMALELFKPHLLSKLEERGYATTLKQAKRMIEQKSNEVWECLQEITEGYPVLLNRAPTLHKQSIQAFHPKLIDGKAIQLHPLVCSAFNADFDGDQMAVHVPLSQEAIAECKVLMLSSMNILLPASGKAVAIPSQDMVLGLYYLSLEKSGVKGEHKLFSSVNEIITAIDTKELDIHAKIRVLDQGNIIATSAGRMIIKSILPDFIPTDLWNRPMKKKDIGVLVDYVHKVGGIGITATFLDNLKTLGFRYATKAGISISMEDIITPKDKQKMVEKAKVEVKKIQQQYDQGLLTDQERYNKIIDTWTEVNDKMSKEMMTAIAQDKEGFNSIYMMADSGARGSAAQIRQLSAMRGLMTKPDGSIIETPIISNFKEGLNVLEYFNSTHGARKGLADTALKTANAGYLTRKLIDVSQNVKVVSDDCGTHEGIEITDIAVGSELIEPLEERIFGRVLLEDVIDPITNEILLYADTLIDEEGAKKVVEAGIKSITIRTPVTCKAPKGVCAKCYGLNLGEGKMSYPGEAVGVVAAQSIGEPGTQLTLRTFHVGGTASRSQDEREIVASKEGFVRFYNLRTYTNKEGKNIIANRRNASILVVEPKIKAPFDGELRIETVYEEVVVSVKNGDQEAKFVLRRSDIVKPSELAGVGGKIEGKVYLPYASGHKVHKGGSIADIIQEGWNVPNRIPYASELLVKDNDPIAQDVYAKEKGVIKYYVLEANHLERTHGIKKGDMVSEKGLFAVIADDNGREAARHYIARGSEILIDDNSEVSTNSVISKPTTNTFKTIATWDPYNTPIIADFKGKVGFVDVIAGVTVAEKEDENTGITSLVVNDYIPSGYKPSLFLEGANGEEMRYFLEPKTSIAISDGSSVEQAEVLAKIPKATVKSRDITGGLPRVSELFEARKPKPKDVAILSEVDGIVSFGKPIRNKEHIIVTSKDGRSMDYFVDKGKQILVHADEFVHAGEAMTDGVISSHDILRISGEKELYKYIVSEVQQVYRRQGVSIADKHIEIIVSQMLRQVRILDSGDSKFIEGDLVSKKLFKEENARVIALKGEPAIAEPVLLGITRAAIGSDSIISAASFQETTKVLTEASIAMKKDFLEDLKENVVLGRMIPVGTGMYKNKKIVLRALEDNSKF"}}}}, "model_name": "Helicobacter pylori rpoB mutation conferring resistance to rifampicin", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "36296": {"category_aro_name": "rifamycin antibiotic", "category_aro_cvterm_id": "36296", "category_aro_accession": "3000157", "category_aro_class_name": "Drug Class", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs."}, "36349": {"category_aro_name": "rifamycin-resistant beta-subunit of RNA polymerase (rpoB)", "category_aro_cvterm_id": "36349", "category_aro_accession": "3000210", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin."}, "35998": {"category_aro_name": "antibiotic target replacement", "category_aro_cvterm_id": "35998", "category_aro_accession": "0001002", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance."}}, "ARO_name": "Helicobacter pylori rpoB mutation conferring resistance to rifampicin", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "CARD_short_name": "Hpyl_rpoB_RIF", "ARO_id": "45610", "model_type_id": "40293"}, "5757": {"model_id": "5757", "ARO_accession": "3007058", "model_param": {"blastp_bit_score": {"param_value": "1000", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}, "snp": {"param_type": "single resistance variant", "param_value": {"12413": "A296V", "12415": "A541M", "12414": "S494H", "12417": "I259T", "12416": "E572G"}, "clinical": {"12413": "A296V", "12415": "A541M", "12414": "S494H", "12417": "I259T", "12416": "E572G"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type. The most common type encoded in the CARD is an amino acid substitution gleaned from the literature with format [wild-type][position][mutation], e.g. R184Q. When present in the associated gene or protein, a single resistance variant confers resistance to an antibiotic drug or drug class. Single resistance variants are used by the protein variant and rRNA mutation models to detect antibiotic resistance from submitted sequences."}}, "ARO_description": "Point mutations in Helicobacter pylori pbp2 observed to confer resistance to amoxicillin.", "model_sequences": {"sequence": {"8370": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAAATCTTCGCTATAAGCTTTTGCTCTTTGTTTTTATAGGGTTTTGGGGGTTATTGGTTTTAAATTTATTTATTTTAAGCGTTAAAAATCAAGAATACTATGAAAAATTGGCCGAACGCAACATGACCAAAAAGGAATTTCTAGTCCCTACAAGGGGCGATATTACAGACAGAAATGATGAGTTTTTAGCCACTAACGAATTGGTGTTTGGCGTGTTTTTGCCTAGTAGACTGAAACAAAAAGAACTTTTGGAAAAAATTGAAATCATCCAAAAGTTTTTCCCTAACTTTTCCAAAGAAACGCTTTTAAACAATTACCAAAAAGAAAATTCGCTTTATAACCACAACCTCATTAAAGTGGTGGGATTCATTCCTTATATCGCCATGCAACCTCTTTATGCCAAACTCATCCAAACTCAAGGCATTTTTGCTCTTCCCTTAGACAAGCGCTACTACCCTAATAACGCTTTAGCTTCACATGTTTTAGGCTATGTGGGGGTGGCAAGCTTGCAAGATCTAAAAGACGATGAAGAAAATCAATACAGCCAGATTGTAGGCAAAACCGGCATTGAAAAAGAATATAACAAGCTTTTACAAGGCAAGGTGGGCTATAAAATCATGCGTGTCAATGCACTCAATCAAGAATTAGCCACTTTAGAAGTAGTGCCGCCAAGCACCAACAACCACTTGCAATTGAGTTTAGACAAACGCTTGCAAAAAGAAGCGGACAAGCTCTTTGAAAATAAGAGAGGGGCTATTTTAGTGATGAACGCAGAAAATGGGGAATTGCTCGTTGCAGGAAGTTACCCTGAATACAATTTGAACGATTTTGTAGGCGGGATCAGTCAAGACAAATGGCAAAAACTTCAAGATGATATTTATAACCCCTTATTAAACCGCTTCGCTAACGCTTTGTATCCGCCGGGATCTGTGGTTAAAATGGGCGTGGGCTTGAGCTTTTTAGAAAACCTTCATATCACAGAAAACACCACCATACCCACCCCGCCTTTTATTGAAGTGGGCAAGCGCAAATTCAGGGACTGGAAAAAAACAGGGCATGGCAATTCTAATTTGTATAAAGCGATTAGGGAGTCCGTGGATGTGTATTTTTATAAGTTTGGGCTTGAAATCTCTATAGAAAAACTCTCTAAAACCTTAAGAGAAGTGGGCTTTGGGGAAAAAACAGGCGTTGATTTGCCGAATGAATTTGTGGGGATTGTGCCGGATAATTTGTGGAAACTCAAACGATTCAATCAAGATTGGCGCGTTGGGGACACGCTCATTACTGCTATTGGGCAAGGCTCTTTTTTAGCCACGCCCTTACAAGTGCTAGCCTATACGGGACTCATTGCGACAGGCAAACTGGCAACGCCTCATTTTGCTATCAATAATAAACAGCCGCTCAAAGACCCCCTGAATAGTTTTCAAAAAAAGAAGCTCCAAGCCTTGCGCGTGGGCATGTATGAAGTGTGTAACCATAAAGACGGCACCGCTTATCATTCCACAAGGGGTTCTAAGGTTACTTTAGCGTGTAAAACCGGCACCGCGCAAGTCGTGGAAATCGCTCAAAACATCGTCAATCGCATGAAAGAAAAGGATATGGAGTATTTCCATCGATCCCATGCGTGGATTACCGCATTTTTGCCTTATGAAAAACCCAAATACGCTATCACTATTTTAGTAGAACATGGGGAAGGGGGGTCAAAACTAGGGGGCTTGTTAGTGAAAATGAGCAATAAACTCTATGAGCTTGGCTATCTTTAA", "fmax": "1883", "accession": "AF315504.1", "fmin": "116", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Helicobacter pylori", "NCBI_taxonomy_id": "210", "NCBI_taxonomy_cvterm_id": "36906"}, "protein_sequence": {"accession": "AAK17127.1", "sequence": "MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGDITDRNDEFLATNELVFGVFLPSRLKQKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYIAMQPLYAKLIQTQGIFALPLDKRYYPNNALASHVLGYVGVASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQKEADKLFENKRGAILVMNAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLSFLENLHITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDLPNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKKLQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFHRSHAWITAFLPYEKPKYAITILVEHGEGGSKLGGLLVKMSNKLYELGYL"}}}}, "model_name": "Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin", "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "40661": {"category_aro_name": "Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics", "category_aro_cvterm_id": "40661", "category_aro_accession": "3003938", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics."}, "35981": {"category_aro_name": "amoxicillin", "category_aro_cvterm_id": "35981", "category_aro_accession": "0000064", "category_aro_class_name": "Antibiotic", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan."}, "35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35962": {"category_aro_name": "cephamycin", "category_aro_cvterm_id": "35962", "category_aro_accession": "0000044", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases."}}, "ARO_name": "Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin", "model_type": "protein variant model", "model_description": "The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.", "CARD_short_name": "Hpyl_pbp2_AMX", "ARO_id": "45619", "model_type_id": "40293"}, "5730": {"model_id": "5730", "ARO_accession": "3007014", "model_param": {"blastp_bit_score": {"param_value": "75", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "A score is a numerical value that describes the overall quality of an alignment with higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. Many AMR detection models use this parameter, including the protein homolog and protein variant models. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of a specific protein amongst a batch of submitted sequences."}}, "ARO_description": "qacJ is a small multidrug resistance (SMR) efflux pump that confers resistance to quaternary ammonium compounds.", "model_sequences": {"sequence": {"8126": {"dna_sequence": {"partial": "0", "sequence": "ATGCCTTACTTATATTTAGTAATAGCGATTATAACTGAAATAATAGGAACTAGTTTCTTAAAAACAGCAGAAGGATTTACAAAACTTTGGCCAACATTAGGCACACTTATTTCATTCGGGATATGTTTCTATTTTTTAAGTGTAACTATGAAATATTTACCACTCAATGTATCTTATGCAACTTGGGCAGGGTTAGGACTAGTTCTTACAACAATAGTTTCAGTTGTAATTTTCAAAGAAAGCGTCAATTTAATTAGTATATTTTCAATAATCTTAATTATTATTGGTGTTGTGCTTCTTAACGTTTTTGGATCAAGTCATTAA", "fmax": "1751", "accession": "AJ512814.1", "fmin": "1427", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Staphylococcus aureus", "NCBI_taxonomy_id": "1280", "NCBI_taxonomy_cvterm_id": "35508"}, "protein_sequence": {"accession": "CAD55144.1", "sequence": "MPYLYLVIAIITEIIGTSFLKTAEGFTKLWPTLGTLISFGICFYFLSVTMKYLPLNVSYATWAGLGLVLTTIVSVVIFKESVNLISIFSIILIIIGVVLLNVFGSSH"}}}}, "model_name": "qacJ", "ARO_category": {"36298": {"category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_cvterm_id": "36298", "category_aro_accession": "3000159", "category_aro_class_name": "Efflux Component", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance."}, "40514": {"category_aro_name": "benzalkonium chloride", "category_aro_cvterm_id": "40514", "category_aro_accession": "3003823", "category_aro_class_name": "Antibiotic", "category_aro_description": "Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent."}, "36004": {"category_aro_name": "small multidrug resistance (SMR) antibiotic efflux pump", "category_aro_cvterm_id": "36004", "category_aro_accession": "0010003", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain."}, "43746": {"category_aro_name": "disinfecting agents and antiseptics", "category_aro_cvterm_id": "43746", "category_aro_accession": "3005386", "category_aro_class_name": "Drug Class", "category_aro_description": "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance."}, "36001": {"category_aro_name": "antibiotic efflux", "category_aro_cvterm_id": "36001", "category_aro_accession": "0010000", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell."}}, "ARO_name": "qacJ", "model_type": "protein homolog model", "model_description": "The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.", "CARD_short_name": "qacJ", "ARO_id": "45483", "model_type_id": "40292"}}}