Model_id Action ARO_name ARO_category Changes To Summary 1718 UPDATE DIM-1 carbapenem; antibiotic inactivation; cephalosporin; DIM beta-lactamase; ARO_description; model_sequences; model_name "UPDATED ARO_description with Dutch imipenemase or DIM-1 is an integron-encoded metallo-beta-lactamase from Pseudomonas stutzeri. UPDATED partial with 0 UPDATED sequence with ATGAGAACACATTTTACAGCGTTATTACTTCTATTCAGCTTGTCTTCGCTTGCTAACGACGAGGTACCTGAGCTAAGAATCGAGAAAGTAAAAGAGAACATCTTTTTGCACACATCATACAGTCGTGTGAATGGGTTTGGTTTGGTCAGTTCAAACGGCCTTGTTGTCATAGATAAGGGTAATGCTTTCATTGTTGATACACCTTGGTCAGACCGAGATACAGAAACGCTCGTACATTGGATTCGTAAAAATGGTTATGAGCTACTGGGGAGTGTTTCTACTCATTGGCATGAGGATAGAACCGCAGGAATTAAATGGCTTAATGACCAATCAATTTCTACGTATGCCACGACTTCAACCAACCATCTCTTGAAAGAAAATAAAAAAGAGCCAGCGAAATACACCTTGAAAGGAAATGAGTCCACATTGGTTGACGGCCTTATCGAAGTATTTTATCCAGGAGGTGGTCATACAATAGACAACGTAGTGGTGTGGTTGCCAAAGTCGAAAATCTTATTTGGCGGCTGTTTTGTGCGTAGCCTTGATTCCGAGGGGTTAGGCTACACTGGTGAAGCCCATATTGATCAATGGTCCCGATCAGCTCAGAATGCTCTGTCTAGGTACTCAGAAGCCCAGATAGTAATTCCTGGCCATGGGAAAATCGGGGATATAGCGCTGTTAAAACACACCAAAAGTCTGGCTGAGACAGCCTCTAACAAATCAATCCAGCCGAACGCTAACGCGTCGGCTGATTGA UPDATED fmax with 796 UPDATED accession with KC004136.2 UPDATED fmin with 40 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterobacter sp. SL1 UPDATED NCBI_taxonomy_id with 1284354 UPDATED NCBI_taxonomy_cvterm_id with 39662 UPDATED accession with AGC92784.1 UPDATED sequence with MRTHFTALLLLFSLSSLANDEVPELRIEKVKENIFLHTSYSRVNGFGLVSSNGLVVIDKGNAFIVDTPWSDRDTETLVHWIRKNGYELLGSVSTHWHEDRTAGIKWLNDQSISTYATTSTNHLLKENKKEPAKYTLKGNESTLVDGLIEVFYPGGGHTIDNVVVWLPKSKILFGGCFVRSLDSEGLGYTGEAHIDQWSRSAQNALSRYSEAQIVIPGHGKIGDIALLKHTKSLAETASNKSIQPNANASAD UPDATED model_name with DIM-1 " 1867 UPDATE CTX-M-116 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-116 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with JF966749.1 " 2031 UPDATE OXA-173 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-173 is a beta-lactamase found in A. baumannii. UPDATED accession with HM113559.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1866 UPDATE KPC-7 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with KPC-7 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with EU729727.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4026 UPDATE PDC-461 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-461 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4027 UPDATE PDC-19a PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-19a is a class C beta-lactamase found in Pseudomonas (multispecies). " 4024 UPDATE PDC-19b PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-19b is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4025 UPDATE PDC-380 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-380 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4022 UPDATE PDC-352 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-352 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4023 UPDATE PDC-464 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-464 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4020 UPDATE PDC-337 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-337 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4021 UPDATE PDC-212 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-212 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 643 UPDATE OXY-2-5 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-5 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ746227.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4028 UPDATE PDC-272 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-272 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4029 UPDATE PDC-255 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-255 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 3383 UPDATE MCR-9.1 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description; model_sequences; model_name "UPDATED ARO_description with A mobilized and plasmid-mediated colistin resistance gene and phosphoethanolamine transferase identified from a Salmonella enterica isolate. UPDATED NCBI_taxonomy_name with Enterobacterales UPDATED model_name with MCR-9.1 " 981 UPDATE OXA-86 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ149247.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2030 UPDATE AAC(3)-IXa antibiotic inactivation; AAC(3); aminoglycoside antibiotic; neomycin; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-IXa is a chromosomal-encoded aminoglycoside acetyltransferase in Micromonospora chalcea. UPDATED accession with M55427.1 " 344 UPDATE SHV-188 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with LN515534.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 345 UPDATE bcrA peptide antibiotic; ATP-binding cassette (ABC) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; bacitracin B; bacitracin F; bacitracin A; ARO_description; model_sequences "UPDATED ARO_description with bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. UPDATED accession with L20573.1 " 346 UPDATE QnrB23 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB23 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with FJ981622.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 347 UPDATE SFH-1 SFH beta-lactamase; carbapenem; antibiotic inactivation; model_sequences "UPDATED accession with AF197943.1 " 340 UPDATE CMY-51 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ733571.1 " 341 UPDATE IMP-1 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-1 is a beta-lactamase found in Serratia marcescens. UPDATED accession with AJ223604.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 342 UPDATE smeS penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with smeS is the protein kinase sensor component of a two component signal transduction system that includes smeR. UPDATED accession with AF173226.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 343 UPDATE OXA-31 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-31 is a beta-lactamase found in P. aeruginosa. UPDATED accession with AF294653.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3997 UPDATE TEM-234 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3996 UPDATE TEM-233 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with TEM-233 is a beta-lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3995 UPDATE TEM-232 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3994 UPDATE TEM-231 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with TEM-231 is a beta-lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 348 UPDATE OXY-3-1 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-3-1 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AF491278.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3992 UPDATE TEM-229 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3991 UPDATE TEM-228 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3990 UPDATE TEM-227 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4930 UPDATE OXA-604 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 595 UPDATE SHV-75 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGCATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 891 UPDATED accession with AM176550.2 UPDATED fmin with 30 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47130.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPHNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4844 UPDATE OXA-509 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 965 UPDATE OXA-333 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203107.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1343 UPDATE OXA-166 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM488987.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 966 UPDATE vanSC glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSC, is a vanS variant found in the vanC gene cluster. UPDATED accession with AF162694.1 UPDATED model_name with vanS gene in vanC cluster UPDATED ARO_name with vanS gene in vanC cluster " 967 UPDATE AAC(6')-Isa AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Isa is a plasmid-encoded aminoglycoside acetyltransferase in Streptomyces albulus. UPDATED accession with AB116646.1 " 1296 UPDATE OKP-B-12 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-12 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AJ635420.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 960 UPDATE TEM-137 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM286274.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 961 UPDATE SHV-93 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF373969.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4732 UPDATE KPC-73 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4733 UPDATE KPC-74 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4730 UPDATE KPC-71 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4731 UPDATE KPC-72 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4736 UPDATE KPC-77 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4737 UPDATE KPC-78 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4734 UPDATE KPC-75 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4735 UPDATE KPC-76 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2317 UPDATE mgrB antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; pmr phosphoethanolamine transferase; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; resistance by absence; erythromycin; ARO_description; ARO_category "UPDATED ARO_description with mgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae. UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). " 2315 UPDATE Acinetobacter baumannii parC conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; model_name "UPDATED model_name with Acinetobacter baumannii parC conferring resistance to fluoroquinolones " 2184 UPDATE glycopeptide resistance gene cluster VanC glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Confers low vancomycin resistance by engineering peptidoglycan precursors ending in D-Ala-D-Ser in an inducible or constitutive manner. The vanC cluster is intrinsic to the Enterococcus gallinarum chromosome. vanC organisms remain susceptible to teicoplanin. Gene orientation: vanC(XY)TRS. " 298 UPDATE vanYG1 glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanYG, is a vanY variant found in the vanG gene cluster. UPDATED accession with DQ212986.1 UPDATED model_name with vanY gene in vanG cluster UPDATED ARO_name with vanY gene in vanG cluster " 299 UPDATE CepS CepS beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; model_name "UPDATED accession with X80277.1 UPDATED model_name with CepS " 296 UPDATE VIM-23 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-23 is a beta-lactamase found in Enterobacter cloacae. UPDATED accession with GQ242167.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 297 UPDATE CMY-98 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KC603538.1 " 294 UPDATE CfxA4 antibiotic inactivation; cephamycin; CfxA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with cfxA4 beta-lactamase is a class A beta-lactamase found in Bacteroides fragilis. UPDATED accession with AY769933.1 UPDATED category_aro_description with CfxA beta-lactamases are class A beta-lactamases. " 295 UPDATE OXA-145 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-145 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with FJ790516.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 292 UPDATE TEM-17 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAACAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTAAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTTTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATTTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA UPDATED fmax with 861 UPDATED accession with Y14574.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Capnocytophaga ochracea UPDATED NCBI_taxonomy_id with 1018 UPDATED NCBI_taxonomy_cvterm_id with 36958 UPDATED accession with CAA74912.2 UPDATED sequence with MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 293 UPDATE SHV-180 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 290 UPDATE vatD dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with vatD is a transposon-mediated acetyltransferase found in Enterococcus faecium. UPDATED accession with AF368302.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 291 UPDATE APH(3')-Ia antibiotic inactivation; aminoglycoside antibiotic; paromomycin; kanamycin A; APH(3'); lividomycin B; ribostamycin; G418; neomycin; lividomycin A; ARO_category "UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 3772 UPDATE FLC-1 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3771 UPDATE FRI-9 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3770 UPDATE FRI-8 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3777 UPDATE CTX-M-165 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamase, no other information available. " 3776 UPDATE CTX-M-164 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamase, no other information available. " 3775 UPDATE CTX-M-163 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamase, no other information available. " 3774 UPDATE CTX-M-162 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamase, no other information available. " 4835 UPDATE OXA-500 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3779 UPDATE Yrc-1 penam; antibiotic inactivation; cephalosporin; YRC Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3778 UPDATE CTX-M-166 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamase, no other information available. " 2782 UPDATE Vibrio cholerae OmpU peptide antibiotic; BPI; General Bacterial Porin with reduced permeability to peptide antibiotics; reduced permeability to antibiotic; model_sequences "UPDATED accession with KJ699300.1 UPDATED accession with AID70696.1 " 4834 UPDATE OXA-498 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 270 UPDATE LEN-20 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-20 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGGTCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGTGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM850910.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12348.2 UPDATED sequence with MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTVGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPVSMAERNQHIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 271 UPDATE CMY-4 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-4 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with Y15130.1 " 272 UPDATE QnrB36 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB36 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JN173058.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 273 UPDATE VEB-7 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ825622.1 UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 274 UPDATE OXA-174 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-174 is a beta-lactamase found in A. baumannii. UPDATED accession with HM113560.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 275 UPDATE OKP-B-2 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-2 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051151.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 276 UPDATE tetR antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; antibiotic target alteration; tetracycline; ARO_description; model_sequences "UPDATED ARO_description with TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin. UPDATED accession with AL513383.1 " 277 UPDATE TEM-91 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB049569.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 278 UPDATE imiS carbapenem; CphA beta-lactamase; antibiotic inactivation; model_sequences "UPDATED accession with Y10415.1 " 279 UPDATE CTX-M-107 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with GGTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAGAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCA UPDATED fmax with 864 UPDATED accession with JF274244.1 UPDATED fmin with 1 UPDATED strand with - UPDATED NCBI_taxonomy_name with Shigella sp. SH219 UPDATED NCBI_taxonomy_id with 1074433 UPDATED NCBI_taxonomy_cvterm_id with 39656 UPDATED accession with AEM44650.1 UPDATED sequence with VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDRTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT " 4836 UPDATE OXA-501 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4659 UPDATE GOB-46 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4658 UPDATE GOB-45 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 962 UPDATE OXA-356 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297585.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 581 UPDATE QnrB19 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB19 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED accession with JX298080.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1612 UPDATE ErmR antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGGCAGGTCCGCAAGACCGTCCGCGAGGGCGCGGACCCTCCTCCGGTCGCCCGCAGCGGCCGGTGGGCGGCCGCAGCCAGCGCGACCGCGACCGGCGGGTCCTCGGCCAGAACTTCCTGCGCGACCCGGCGACCATCCGGCGCATCGCCGACGCCGCCGACGTCGACCCCGACGGGCTCGTCGTCGAGGCGGGTCCCGGCGAAGGGCTGCTCACCCGCGAGCTCGCCCGACGCGCCGGGCGGGTACGCACCTACGAGCTGGACCAGCGCCTCGCGCGACGACTCTCGACCGACCTGGCCCAGGAGACGAGCATCGAGGTCGTCCACGCCGACTTCCTGACCGCGCCTCACCCCGAGGAGCCGTTCCAGTTCGTCGGCGCGATCCCCTACGGCATCACCTCCGCCATCGTCGACTGGTGCCTGACCGCCCCGACCCTGACGTCGGCGACCCTCGTGACCCAGCAGGAGTTCGCGCGCAAGCGGACGGGTGACTACGGACGGTGGACGGCCCTCACCGTCACCACGTGGCCGACCTTCGAGTGGCAGTACGTCGCCAAGGTCGACCGCACGCTGTTCACACCGGTGCCGCGCGTGCACTCCGCGATCATGCGGCTGCGCCGCCGCCCACAGCCCCTCCTGCGCGACGCGGCGGCGAGGTCGCGCTTCGCGGACATGGTGGAGATCGGCTTCGTCGGCAAGGGCGGCAGCCTCTACCGGTCGCTGACCCGGGAGTGGCCGCGCTCGAAGGTCGACAGCGCGTTCGCGCGCGCCGACGTCCACCACGACGAGATCGTCGCCTTCGTGCACCCCGACCAGTGGATCACGCTGTTCCAGCTCCTCGACGGGTCCCGTGGCGGCGCCGCGCGCGGACCGGGCGACCAGCGGGGGCGGCGCGGCCGCCCAGGCGGAGGCCCCCGGCCGGACGGTCGCGCGGGCGGCGGCCCGCGCCGCGACGCGGGCGGGCGCCGCACGGGTGACGGACGCGGAGGTCGCCCCCGTCCCCCGCGCGGCGGCCAGGCCTAG UPDATED fmax with 13472 UPDATED accession with AY623658.2 UPDATED fmin with 12449 UPDATED strand with + UPDATED NCBI_taxonomy_name with Aeromicrobium erythreum UPDATED NCBI_taxonomy_id with 2041 UPDATED NCBI_taxonomy_cvterm_id with 40506 UPDATED accession with AAU93796.1 UPDATED sequence with MAGPQDRPRGRGPSSGRPQRPVGGRSQRDRDRRVLGQNFLRDPATIRRIADAADVDPDGLVVEAGPGEGLLTRELARRAGRVRTYELDQRLARRLSTDLAQETSIEVVHADFLTAPHPEEPFQFVGAIPYGITSAIVDWCLTAPTLTSATLVTQQEFARKRTGDYGRWTALTVTTWPTFEWQYVAKVDRTLFTPVPRVHSAIMRLRRRPQPLLRDAAARSRFADMVEIGFVGKGGSLYRSLTREWPRSKVDSAFARADVHHDEIVAFVHPDQWITLFQLLDGSRGGAARGPGDQRGRRGRPGGGPRPDGRAGGGPRRDAGGRRTGDGRGGRPRPPRGGQA UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 1132 UPDATE OXA-88 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-88 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ392963.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2263 UPDATE optrA pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; model_sequences "UPDATED accession with KP399637.1 UPDATED accession with AKA86814.1 " 2260 UPDATE vatF dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin antibiotic; model_sequences; ARO_category "UPDATED accession with AF170730.1 UPDATED accession with AAF63432.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 2261 UPDATE lnuE antibiotic inactivation; lincosamide nucleotidyltransferase (LNU); lincosamide antibiotic; model_sequences "UPDATED accession with KF287643.1 UPDATED accession with AGT57825.1 " 2264 UPDATE oleC efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; macrolide antibiotic; oleandomycin; antibiotic efflux; model_sequences "UPDATED accession with L06249.1 UPDATED accession with AAA26793.1 " 2265 UPDATE salA retapamulin; virginiamycin M1; pleuromutilin antibiotic; tiamulin; macrolide antibiotic; lincomycin; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; clindamycin; phenicol antibiotic; lincosamide antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with salA is an ABC-F subfamily protein gene isolated from the chromosome of Mammaliicoccus sciuri conferring resistance to lincosamides and streptogramins. UPDATED accession with KC693025.1 UPDATED NCBI_taxonomy_name with Mammaliicoccus sciuri UPDATED NCBI_taxonomy_id with 1296 UPDATED NCBI_taxonomy_cvterm_id with 36794 UPDATED accession with AGN74946.1 DELETED 37716 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_cvterm_id with 37013 UPDATED category_aro_accession with 3000669 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with retapamulin UPDATED category_aro_cvterm_id with 37713 UPDATED category_aro_accession with 3001314 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections. UPDATED category_aro_name with tiamulin UPDATED category_aro_cvterm_id with 37015 UPDATED category_aro_accession with 3000671 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation. UPDATED category_aro_name with clindamycin UPDATED category_aro_cvterm_id with 35983 UPDATED category_aro_accession with 0000066 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria. " 963 UPDATE CMY-69 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JX049132.1 " 2445 UPDATE Erm(44)v antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; model_name "UPDATED model_name with Erm(44)v " 47 UPDATE OXA-60 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-60 is a beta-lactamase found in Ralstonia pickettii. UPDATED partial with 0 UPDATED sequence with ATGCTGTCTCGCTACTCGAAGACCCTCGCGTTTGCCGTGGTGGCCTGCACGCTCGCAATAAGCACCGCCACCGCTCATGCCGAGCTGGTCGTGCGCAATGACCTCAAGCGCGTGTTCGACGACGCCGGCGTCTCCGGCACCTTCGTGCTGATGGACATCACCGCCGACCGTACCTATGTCGTCGATCCGGCGCGTGCCGCGCGGAGCATCCATCCGGCTTCGACGTTCAAGATTCCGAACAGCCTGATCGCCTTCGACACCGGGGCCGTGCGCGACGATCAGGAAGTGCTGCCCTACGGCGGCAAGCCGCAGCCTTACGAGCAGTGGGAGCACGACATGGCGTTACCCGAGGCGATTCGCCTGTCGGCCGTGCCGATCTATCAGGAAGTCGCGCGCCGCGTTGGCTTCGAGCGCATGCAGGCTTATGTCGATGCGTTCGACTACGGCAATCGCCAGCTCGGCAGCGCGATCGACCAGTTCTGGCTGCGTGGCCCGCTGGAGATTTCCGCTTTCGAAGAAGCACGCTTCACCAGCCGCATGGCGCTCAAGCAGTTGCCGGTGAAGCCGCGCACGTGGGACATGGTCCAGCGCATGCTGTTGATCGAGCAGCAGGGCGATGCCGCGCTATATGCCAAGACCGGCGTCGCCACCGAATACCAGCCGGAGATCGGTTGGTGGGCCGGCTGGGTGGAGCGTGCGGGGCATGTCTATGCATTCGCGCTGAACATCGACATGCCGCGCGAGGGCGATATGGCCAAGCGCATTCCGCTGGGCAAGCAGTTGATGCGGGCGCTCGAGGTGTGGCCGGCACCGTGA UPDATED fmax with 3586 UPDATED accession with AF525303.2 UPDATED fmin with 2770 UPDATED strand with + UPDATED NCBI_taxonomy_name with Ralstonia pickettii UPDATED NCBI_taxonomy_id with 329 UPDATED NCBI_taxonomy_cvterm_id with 36921 UPDATED accession with AAQ08905.1 UPDATED sequence with MLSRYSKTLAFAVVACTLAISTATAHAELVVRNDLKRVFDDAGVSGTFVLMDITADRTYVVDPARAARSIHPASTFKIPNSLIAFDTGAVRDDQEVLPYGGKPQPYEQWEHDMALPEAIRLSAVPIYQEVARRVGFERMQAYVDAFDYGNRQLGSAIDQFWLRGPLEISAFEEARFTSRMALKQLPVKPRTWDMVQRMLLIEQQGDAALYAKTGVATEYQPEIGWWAGWVERAGHVYAFALNIDMPREGDMAKRIPLGKQLMRALEVWPAP UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 108 UPDATE PDC-8 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED accession with FJ666071.1 " 109 UPDATE ErmE antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with X51891.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 103 UPDATE SHV-12 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; cefalotin; ceftriaxone; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ920369.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 100 UPDATE Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide antibiotic target alteration; ethionamide; ethionamide resistant ethA; ARO_description; ARO_category "UPDATED ARO_description with Specific mutations that occurs on Mycobacterium tuberculosis ethA causing it to be ethionamide resistant. UPDATED category_aro_description with ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis. UPDATED category_aro_description with Mutations that occurs on the ethA genes resulting in the inability to catalyzes the oxidation of ethionamide (ETH) to the corresponding sulfoxide (the active drug). " 101 UPDATE TEM-109 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY628175.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 106 UPDATE catB9 antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with catB9 is a chromosome-encoded variant of the cat gene found in Vibrio cholerae. UPDATED accession with AF462019.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 107 UPDATE TEM-43 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTAAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCTGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCATTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGACGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA UPDATED fmax with 861 UPDATED accession with U95363.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAC32889.2 UPDATED sequence with MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 104 UPDATE OXA-61 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-61 is a beta-lactamase found in Campylobacter jejuni. UPDATED accession with AY587956.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 105 UPDATE CARB-4 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-4 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with U14749.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2047 UPDATE OXA-322 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203096.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2044 UPDATE QnrB31 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB31 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGACGCCATTACTGTATAAGAAAACAGGTACAAATATGGCTCTGGCGCTCGTGGGCGAAAAAATTGACAGAAACCGTTTCACCGGTGAGAAAATTGAAAATAGTACATTTTTTTTATGTGATTTTTCAGGAGCCGACCTGAGCGGCACTGAGTTTATCGGCTGTCAATTCTATGATCGTGAAAGCCAGAAAGGCTGCAATTTTAGTCGTGCGATGTTAAAGGATGCCATTTTTAAAAGCTGCGATTTATCCATGGCGGATTTTCGCAATGCAAGCGCCCTGGGTATTGAGATTTCTCATTGTAGGGCTCAGGGTGCAGATTTTCGCGGCGCAAGCTTTATGAACATGATTACCACGCGCACTTGGTTCTGCAGCGCGTATATCACGAATACGAATCTGTCTTATGCCAATTTTTCGAAAGTCGTGTTGGAGAAGTGTGAGTTATGGGAAAACCGTTGGATGGGTGCCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCAACTTTCGACTGGCGAGCAGCAAACTTTACACATTGCGATCTCACAAATTCGGAGTTGGGTGACTTAGATATTCGTCGGGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCTTCGTTGCTCATGGAGCGACTTGGCATCGCGATAATTGGTTGA UPDATED fmax with 681 UPDATED accession with HQ418999.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with ADQ43424.1 UPDATED sequence with MTPLLYKKTGTNMALALVGEKIDRNRFTGEKIENSTFFLCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEISHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGAQVLGATFSGSDLSGGEFSTFDWRAANFTHCDLTNSELGDLDIRRVDLQGVKLDNYQASLLMERLGIAIIG UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 2045 UPDATE OXY-2-3 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-3 is a beta-lactamase found in Klebsiella oxytoca. UPDATED partial with 0 UPDATED sequence with ATGATAAAAAGTTCGTGGCGTAAAATTGCAATGCTAGCCGCCGTTCCGCTGCTGCTGGCGAGCGGCGCACTGTGGGCCAGTACCGATGCTATCCATCAGAAGCTGACAGATCTCGAGAAGCGTTCAGGCGGCAGGTTGGGCGTGGCGCTAATCAACACGGCAGATAATTCTCAAATCTTATATCGCGGCGACGAGCGTTTTGCCATGTGCAGCACCAGTAAAGTGATGGCCGCCGCCGCGGTATTAAAACAGAGCGAAAGCAATAAAGAGGTGGTAAATAAAAGGCTGGAGATTAACGCAGCCGATTTGGTGGTCTGGAGTCCGATTACCGAAAAACATCTCCAGAGCGGAATGACGCTGGCTGAGCTAAGCGCGGCGACGCTGCAATATAGCGACAATACGGCGATGAATCTGATCATCGGCTACCTTGGCGGGCCGGAAAAAGTCACCGCCTTCGCCCGCAGTATCGGCGATGCCACCTTTCGTCTCGATCGTACGGAGCCCACGCTGAATACCGCCATCCCGGGCGATGAGCGTGATACCAGCACGCCGCTGGCGATGGCTGAAAGCCTACGCAAGCTGACGCTTGGCGATGCGCTGGGCGAACAGCAACGCGCCCAGTTAGTCACCTGGCTGAAAGGCAATACCACCGGCGGGCAAAGCATTCGCGCGGGCCTGCCTGAAAGCTGGGTGGTCGGCGATAAAACCGGCGGCGGAGATTACGGCACCACCAATGATATTGCGGTTATCTGGCCGGAAGATCACGCTCCGCTGGTATTAGTCACCTACTTTACCCAGCCGCAGCAGGATGCGAAAAACCGCAAAGAGGTGTTAGCCGCAGCGGCAAAAATCGTGACCGAAGGGCTTTAA UPDATED fmax with 1031 UPDATED accession with AY077488.2 UPDATED fmin with 161 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella oxytoca UPDATED NCBI_taxonomy_id with 571 UPDATED NCBI_taxonomy_cvterm_id with 36788 UPDATED accession with AAL78281.2 UPDATED sequence with MIKSSWRKIAMLAAVPLLLASGALWASTDAIHQKLTDLEKRSGGRLGVALINTADNSQILYRGDERFAMCSTSKVMAAAAVLKQSESNKEVVNKRLEINAADLVVWSPITEKHLQSGMTLAELSAATLQYSDNTAMNLIIGYLGGPEKVTAFARSIGDATFRLDRTEPTLNTAIPGDERDTSTPLAMAESLRKLTLGDALGEQQRAQLVTWLKGNTTGGQSIRAGLPESWVVGDKTGGGDYGTTNDIAVIWPEDHAPLVLVTYFTQPQQDAKNRKEVLAAAAKIVTEGL UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2042 UPDATE IND-8 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-8 is a beta-lactamase found in Escherichia coli. UPDATED accession with GU186044.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 2043 UPDATE aadA8 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA8 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in V. cholerae, K. pneumoniae and Bacillus endophyticus. UPDATED accession with AY139603.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 2040 UPDATE TEM-60 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF047171.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2041 UPDATE OXA-424 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM588352.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4819 UPDATE OXA-114t carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4818 UPDATE OXA-114s carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1297 UPDATE CTX-M-80 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-80 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACCGTGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGACTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA UPDATED fmax with 876 UPDATED accession with EU202673.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with ABW86620.2 UPDATED sequence with MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL " 2048 UPDATE OXA-57 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-57 is a beta-lactamase found in Burkholderia pseudomallei. UPDATED accession with AJ631966.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2049 UPDATE QnrB72 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB72 is a plasmid-mediated quinolone resistance protein found in Citrobacter sp. TR21_24. UPDATED accession with KC741443.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1189 UPDATE vatB dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. UPDATED accession with U19459.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 4144 UPDATE ACT-53 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 449 UPDATE SHV-133 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB551737.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1364 UPDATE CMY-101 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KF526114.1 " 1060 UPDATE SHV-103 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU032604.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4849 UPDATE OXA-514 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3519 UPDATE OXA-450 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3518 UPDATE OXA-449 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3513 UPDATE OXA-443 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3512 UPDATE OXA-442 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3511 UPDATE OXA-441 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3510 UPDATE OXA-440 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3517 UPDATE OXA-448 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3516 UPDATE OXA-447 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3515 UPDATE OXA-446 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3514 UPDATE OXA-444 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1420 UPDATE aadA5 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA5 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli, K. pneumoniae, Kluyvera georgiana, P. aeruginosa and E. cloacae. UPDATED accession with AF137361.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 2688 UPDATE ArmR sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2689 UPDATE Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid 23S rRNA with mutation conferring resistance to linezolid antibiotics; pleuromutilin antibiotic; macrolide antibiotic; linezolid; streptogramin antibiotic; glycopeptide antibiotic; oxazolidinone antibiotic; antibiotic target alteration; phenicol antibiotic; lincosamide antibiotic; ARO_description "UPDATED ARO_description with Point mutations in the 23S rRNA subunit of the large ribosomal bacterial subunit in Staphylococcus aureus, which confer resistance to linezolid by disrupting antibiotic target binding. " 2685 UPDATE Pseudomonas aeruginosa CpxR sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; amoxicillin; penam; aminoglycoside antibiotic; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2686 UPDATE MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2680 UPDATE MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2681 UPDATE Escherichia coli fabG mutations conferring resistance to triclosan antibiotic target alteration; antibiotic resistant fabG; triclosan; disinfecting agents and antiseptics; ARO_category; model_name "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED model_name with Escherichia coli fabG mutations conferring resistance to triclosan " 2682 UPDATE MexAB-OprM with NalC mutations conferring resistance to aztreonam sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2683 UPDATE MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; nalidixic acid; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; trimethoprim; azithromycin; chloramphenicol; model_description; ARO_category; model_name "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics " 1436 UPDATE TEM-40 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FR717535.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 122 UPDATE VIM-34 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-34 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with JX013656.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3999 UPDATE TEM-236 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1437 UPDATE AcrF penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; ciprofloxacin; fluoroquinolone antibiotic; model_sequences; model_name; ARO_category "UPDATED accession with U00096.1 UPDATED model_name with AcrF UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 645 UPDATE mecR1 penam; methicillin resistant PBP2; methicillin; antibiotic target replacement; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3998 UPDATE TEM-235 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 99 UPDATE QnrB38 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB38 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED partial with 0 UPDATED sequence with ATGGCTCTGGCATTAATTGGCGAAAAAATTGACAGAAACCGCTTCACCGGTGAAAAAGTTGAAAATAGCACTTTTTTTAACTGTGATTTTTCGGGTGCCGACCTTAGCGGTACTGAATTTATCGGCTGTCAGTTCTATGATCGAGAAAGCCAGAAAGGGTGCAATTTCAGTCGCGCAATACTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAACGTCAGTGCGTTGGGCATAGAAATTCGCCACTGCCGCGCACAGGGTGCAGATTTTCGCGGCGCAAGTTTCATGAATATGATCACCACGCGCACCTGGTTTTGCAGCGCATATATCACTAATACCAATCTAAGCTACGCCAACTTTTCGAAGGCCGTGCTTGAAAAGTGCGAATTGTGGGAAAATCGCTGGATGGGAACTCAGGTACTGGGTGCGACGTTGAGTGGTTCCGATCTCTCCGGTGGCGAGTTTTCGTCGTTCGACTGGCGGACGGCAAATTTCACGCACTGTGATTTGACCAATTCAGAACTGGGTGATTTAGATATTCGGGGCGTCGATTTACAAGGTGTCAAATTGGACAGCTATCAGGCCGCATTGCTCATGGAACGTCTTGGCATCGCTGTCATTGGCTAA UPDATED fmax with 2951 UPDATED accession with JN173060.2 UPDATED fmin with 2306 UPDATED strand with + UPDATED NCBI_taxonomy_name with Citrobacter freundii UPDATED NCBI_taxonomy_id with 546 UPDATED NCBI_taxonomy_cvterm_id with 36915 UPDATED accession with AEL00461.1 UPDATED sequence with MALALIGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAILKDAIFKSCDLSMADFRNVSALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKAVLEKCELWENRWMGTQVLGATLSGSDLSGGEFSSFDWRTANFTHCDLTNSELGDLDIRGVDLQGVKLDSYQAALLMERLGIAVIG UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 98 UPDATE CMY-48 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA UPDATED fmax with 2185 UPDATED accession with HM569226.2 UPDATED fmin with 1039 UPDATED strand with + UPDATED NCBI_taxonomy_name with Citrobacter freundii UPDATED NCBI_taxonomy_id with 546 UPDATED NCBI_taxonomy_cvterm_id with 36915 UPDATED accession with ADP02979.1 UPDATED sequence with MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ " 91 UPDATE gadX penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; cloxacillin; fluoroquinolone antibiotic; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 90 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to rifampicin rifampin; rifapentine; rifabutin; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); antibiotic target replacement; antibiotic target alteration; rifaximin; rifamycin antibiotic; ARO_description "UPDATED ARO_description with Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to rifampicin. " 93 UPDATE SHV-105 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ194944.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 92 UPDATE CTX-M-42 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-42 is a beta-lactamase found in Escherichia coli. UPDATED accession with DQ061159.1 " 95 UPDATE CMY-56 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-56 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with HQ322613.1 " 94 UPDATE CMY-79 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ733576.1 " 97 UPDATE vanXYC glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanXY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXYC, is a vanXY variant found in the vanC gene cluster. UPDATED accession with AF162694.1 UPDATED model_name with vanXY gene in vanC cluster UPDATED ARO_name with vanXY gene in vanC cluster " 96 UPDATE OXA-426 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-426 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem resistant. UPDATED accession with KM588354.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1623 UPDATE GIM-2 penam; GIM beta-lactamase; penem; carbapenem; cephalosporin; antibiotic inactivation; cephamycin; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GIM-2 is a metallo-beta-lactamase present on an integron found in clinical isolates of Enterobacter cloacae in Germany. UPDATED accession with KM659858.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1622 UPDATE vanWG glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanW; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanWG, is a vanW variant found in the vanG gene cluster. UPDATED accession with DQ212986.1 UPDATED model_name with vanW gene in vanG cluster UPDATED ARO_name with vanW gene in vanG cluster " 1993 UPDATE QnrB74 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB74 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED accession with KJ415247.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1620 UPDATE CTX-M-156 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KM211509.1 " 1627 UPDATE CTX-M-95 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with FN813245.1 " 1994 UPDATE gimA antibiotic inactivation; methymycin; oleandomycin; chalcomycin; gimA family macrolide glycosyltransferase; macrolide antibiotic; tylosin; model_sequences; ARO_category "UPDATED accession with AJ223970.1 UPDATED category_aro_description with Produced by Streptomyces bikiniensis. " 1625 UPDATE OXA-179 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM570035.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1624 UPDATE lmrD efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; lincosamide antibiotic; ARO_description "UPDATED ARO_description with lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC. " 1999 UPDATE TEM-215 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP050492.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1998 UPDATE CTX-M-83 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-83 is a beta-lactamase found in Salmonella enterica. UPDATED accession with FJ214366.1 " 1629 UPDATE TEM-197 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ877606.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1628 UPDATE SHV-154 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121121.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 349 UPDATE vanL glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VanL is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. UPDATED accession with EU250284.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 3535 UPDATE OXA-473 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3534 UPDATE OXA-472 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2860 UPDATE PDC-81 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2861 UPDATE PDC-82 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2862 UPDATE PDC-83 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2863 UPDATE PDC-84 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 559 UPDATE vanXYE glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanXY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXY, is a vanXY variant found in the vanE gene cluster. UPDATED accession with FJ872411.1 UPDATED model_name with vanXY gene in vanE cluster UPDATED ARO_name with vanXY gene in vanE cluster " 558 UPDATE qacB efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; major facilitator superfamily (MFS) antibiotic efflux pump; antibiotic efflux; ARO_description; model_sequences "UPDATED ARO_description with qacB is a subunit of the qac multidrug efflux pump. UPDATED accession with AF535087.1 " 2866 UPDATE PDC-87 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2867 UPDATE PDC-88 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 555 UPDATE OXA-133 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-133 is a beta-lactamase found in A. radioresistens. UPDATED accession with EU571228.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 554 UPDATE OXA-163 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-163 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with HQ700343.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 557 UPDATE SHV-9 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with S82452.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 556 UPDATE vanYB glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanYB, is a vanY variant found in the vanB gene cluster. UPDATED accession with U35369.1 UPDATED model_name with vanY gene in vanB cluster UPDATED ARO_name with vanY gene in vanB cluster " 551 UPDATE CTX-M-117 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-117 is a beta-lactamase found in Escherichia coli. UPDATED accession with JN227085.1 " 550 UPDATE CMY-71 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ711184.1 " 553 UPDATE VIM-35 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX982634.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 552 UPDATE QnrB28 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB28 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with HM439643.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 5054 UPDATE OXA-745 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1438 UPDATE SHV-19 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF117743.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5055 UPDATE OXA-746 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1439 UPDATE SHV-80 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCACAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM176555.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47135.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPTGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1199 UPDATE SHV-168 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX870080.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1198 UPDATE mef(B) efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; macrolide antibiotic; antibiotic efflux; model_name "UPDATED model_name with mef(B) " 3349 UPDATE tetU tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; ARO_description "UPDATED ARO_description with Tetracycline-resistant determinant encoded on the plasmid pKQ10 in Enterococcus faecium. " 1191 UPDATE mdtM antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; lincomycin; puromycin; acriflavine; nucleoside antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; phenicol antibiotic; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with Multidrug resistance protein MdtM. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 1190 UPDATE OXA-354 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297583.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1193 UPDATE ErmH antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with ErmH is a plasmid-mediated methyltransferase found in Streptomyces thermotolerans. UPDATED accession with M16503.1 " 1192 UPDATE VEB-1 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 1195 UPDATE SHV-55 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTTTATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGAGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTAGCAAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATCGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AJ863560.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAI10727.2 UPDATED sequence with MRFIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1194 UPDATE OXA-16 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF043100.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1197 UPDATE Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin antibiotic target alteration; antibiotic-resistant rpsL; streptomycin; aminoglycoside antibiotic; model_sequences; ARO_category "UPDATED accession with AE000516.1 UPDATED category_aro_description with Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer antibiotic resistance. " 1196 UPDATE OXA-71 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-71 is a beta-lactamase found in A. baumannii. UPDATED accession with AY750913.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1759 UPDATE vanF glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VanF is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance in Paenibacillus popilliae. UPDATED accession with AF155139.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 1758 UPDATE OXA-326 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203100.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1757 UPDATE emrA efflux pump complex or subunit conferring antibiotic resistance; nalidixic acid; major facilitator superfamily (MFS) antibiotic efflux pump; fluoroquinolone antibiotic; antibiotic efflux; model_sequences "UPDATED accession with AP009048.1 " 1756 UPDATE CMY-93 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KF992025.1 " 1755 UPDATE CTX-M-23 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-23 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AF488377.1 " 1754 UPDATE vanO glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; model_sequences; ARO_category "UPDATED accession with KF478993.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 1753 UPDATE SHV-148 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121115.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1752 UPDATE MdtK efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; antibiotic efflux; multidrug and toxic compound extrusion (MATE) transporter; ciprofloxacin; model_name "UPDATED model_name with MdtK " 1751 UPDATE Erm(33) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Mammaliicoccus sciuri UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 1750 UPDATE OXA-254 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-254 is a beta-lactamase found in A. baumannii. UPDATED accession with AB781687.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1177 UPDATE KPC-12 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ641421.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1176 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid isoniazid; isoniazid resistant katG; antibiotic target alteration; ARO_category; model_param "UPDATED category_aro_description with Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. It is a catalase-peroxidases that catalyzes the activation of isoniazid. Mutations that arises within this protein cause changes that results in the inability for katG to activate antibiotics, conferring resistance. UPDATED 12300 with P365R UPDATED 12300 with P365R " 1174 UPDATE QnrB22 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB22 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. UPDATED accession with FJ981621.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1173 UPDATE TEM-54 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF104442.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1172 UPDATE OXA-194 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ425492.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1171 UPDATE tet(44) chlortetracycline; demeclocycline; oxytetracycline; tetracycline antibiotic; tetracycline; antibiotic target protection; minocycline; tetracycline-resistant ribosomal protection protein; doxycycline; model_sequences; model_name "UPDATED accession with FN594949.1 UPDATED model_name with tet(44) " 1170 UPDATE CMY-46 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with FN556186.1 " 1179 UPDATE IMP-4 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-4 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with AF244145.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1178 UPDATE CMY-81 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ733578.1 " 513 UPDATE CARB-19 penam; antibiotic inactivation; CARB beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ934267.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 644 UPDATE OXY-2-1 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-1 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ871866.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1285 UPDATE SAT-2 streptothricin acetyltransferase (SAT); streptothricin; antibiotic inactivation; nucleoside antibiotic; model_sequences; model_name "UPDATED accession with AB211124.1 UPDATED model_name with SAT-2 " 1284 UPDATE IND-15 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-15 is a beta-lactamase found in Escherichia coli. UPDATED accession with AB563173.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 1287 UPDATE CTX-M-110 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JF274242.1 " 1004 UPDATE vanRD glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRD, is a mutated vanR variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. UPDATED accession with AY082011.1 UPDATED model_name with vanR gene in vanD cluster UPDATED ARO_name with vanR gene in vanD cluster " 1281 UPDATE OXA-110 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-110 is a beta-lactamase found in A. baumannii. UPDATED accession with EF650036.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1280 UPDATE QnrB12 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB12 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. UPDATED accession with AM774474.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1283 UPDATE KPC-6 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with KPC-6 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with EU555534.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1282 UPDATE SIM-1 carbapenem; penam; cephalosporin; antibiotic inactivation; SIM beta-lactamase; ARO_description; model_sequences; model_name; ARO_category "UPDATED ARO_description with SIM-1 is an integron-encoded Ambler class B beta-lactamase isolated from Acinetobacter baumannii. UPDATED accession with GQ288397.1 UPDATED model_name with SIM-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1003 UPDATE OXA-18 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with U85514.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1289 UPDATE OKP-B-7 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-7 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051156.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1288 UPDATE OXA-82 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-82 is a beta-lactamase found in A. baumannii. UPDATED accession with EU019536.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1002 UPDATE AAC(6')-Ib4 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; model_sequences "UPDATED accession with AF445082.1 " 876 UPDATE smeE antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; fluoroquinolone antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with smeE is the RND protein of the efflux complex smeDEF in Stenotrophomonas maltophilia. UPDATED accession with AJ252200.1 " 1579 UPDATE QnrB9 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB9 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with EF526508.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1578 UPDATE SHV-123 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ390805.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 689 UPDATE CTX-M-123 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-123 is a beta-lactamase found in Escherichia coli. UPDATED accession with JN790864.1 " 688 UPDATE MOX-2 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with MOX-2 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AJ276453.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1872 UPDATE vanXYL glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanXY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXYL, is a vanXY variant found in the vanL gene cluster. UPDATED accession with EU250284.1 UPDATED model_name with vanXY gene in vanL cluster UPDATED ARO_name with vanXY gene in vanL cluster " 877 UPDATE SHV-124 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ390806.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 685 UPDATE OXA-239 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ837239.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 684 UPDATE SHV-37 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF467948.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 687 UPDATE APH(3')-Vc antibiotic inactivation; aminoglycoside antibiotic; paromomycin; APH(3'); ribostamycin; G418; neomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-Vc is a chromosomal-encoded aminoglycoside phosphotransferase in M. chalcea. UPDATED accession with S81599.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 686 UPDATE OXA-162 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-162 is a beta-lactamase found in Enterobacteriaceae. UPDATED accession with HM015773.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 681 UPDATE TEM-120 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY243512.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 680 UPDATE CMY-54 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-54 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with HM544039.1 " 683 UPDATE CMY-75 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ733572.1 " 682 UPDATE QnrS4 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrS4 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. UPDATED accession with FJ418153.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1227 UPDATE aadA2 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; model_sequences; ARO_category "UPDATED accession with AF156486.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 875 UPDATE dfrA19 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA19 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. UPDATED accession with AJ310778.1 " 469 UPDATE SHV-49 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY528718.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 872 UPDATE vatC dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with vatC is a plasmid-mediated acetyltransferase found in Staphylococcus cohnii. UPDATED accession with AF015628.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 1225 UPDATE TEM-178 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with X97254.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3435 UPDATE OXA-268 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 620 UPDATE OXA-320 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-320 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with KF151169.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 870 UPDATE otr(B) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; ARO_description; model_sequences "UPDATED ARO_description with otr(B) is a tetracycline resistance efflux pump found in Streptomyces rimosus. UPDATED accession with AF079900.1 " 1223 UPDATE vph peptide antibiotic; viomycin phosphotransferase; antibiotic inactivation; viomycin; ARO_description; model_sequences; model_name "UPDATED ARO_description with vph is a phosphotransferase that confers resistance to viomycin in Streptomyces vinaceus. UPDATED accession with X02393.1 UPDATED model_name with vph " 871 UPDATE CGB-1 carbapenem; penam; cephalosporin; antibiotic inactivation; CGB beta-lactamase; ARO_description; model_sequences; model_name; ARO_category "UPDATED ARO_description with CGB-1 is an Ambler class B beta-lactamase that mediates resistance for carbapenems in Chryseobacterium gleum. UPDATED accession with EF672680.1 UPDATED model_name with CGB-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 626 UPDATE vanHB glycopeptide antibiotic; glycopeptide resistance gene cluster; vanH; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanHB, is a vanH variant in the vanB gene cluster. UPDATED accession with U35369.1 UPDATED model_name with vanH gene in vanB cluster UPDATED ARO_name with vanH gene in vanB cluster " 2037 UPDATE tetT chlortetracycline; demeclocycline; oxytetracycline; tetracycline antibiotic; tetracycline; antibiotic target protection; minocycline; tetracycline-resistant ribosomal protection protein; doxycycline; model_sequences "UPDATED accession with L42544.1 " 4389 UPDATE BlaB-28 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4388 UPDATE BlaB-27 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 625 UPDATE QnrB46 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB46 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGACGCCATTACTGTATAAGAAAACAGGAACAAATATGGCTCTAGCGCTCGTGGGCGAAAAAATTGACAGAAACCGTTTCACCGGTGAAAAAATTGAAAATAGTACATTTTTTAACTGTGATTTTTCAGGAGCGGACCTGAGCGGCACTGAGTTTATCGGCTGCCAATTTTATGATCGTGAAAGCCAGAAAGGCTGTAATTTTAGCCGTGCGATGTTAAAGGATGCTATTTTTAAAAGCTGCGATTTATCCATGGCCGATTTTCGCAATGCAAGCGCCCTGGGTATTGAGATTCGTCATTGTAGGGCTCAGGGTGCAGATTTTCGCGGCGCAAGCTTTATGAACATGATTACCACGCGAACTTGGTTCTGCAGCGCGTATATCACGAATACGAATCTGTCTTATGCCAATTTTTCGAAAGCAGTGTTGGAGAAGTGTGAATTATGGGAAAACCGTTGGATGGGTGCCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCAACTTTCGACTGGCGAGCAGCAAACTTTACACATTGCGATCTCACAAATTCGGAGTTGGGTGACTTAGATATTCGTCGGGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCTTCGTTGCTCATGGAGCGACTTGGCATCGCGATAATTGGATGA UPDATED fmax with 681 UPDATED accession with HQ704413.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with ADW54092.1 UPDATED sequence with MTPLLYKKTGTNMALALVGEKIDRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKAVLEKCELWENRWMGAQVLGATFSGSDLSGGEFSTFDWRAANFTHCDLTNSELGDLDIRRVDLQGVKLDNYQASLLMERLGIAIIG UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 5629 UPDATE PLN-1 carbapenem; antibiotic inactivation; PLN beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4383 UPDATE BlaB-22 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4382 UPDATE BlaB-20 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4381 UPDATE BlaB-2 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4380 UPDATE BlaB-19 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4387 UPDATE BlaB-26 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5622 UPDATE PFM-1 carbapenem; antibiotic inactivation; PFM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4385 UPDATE BlaB-24 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4384 UPDATE BlaB-23 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 407 UPDATE OXA-352 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297581.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 406 UPDATE ACC-4 penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACC-4 is a beta-lactamase found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGCAGAACACATTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGTCCAAGGTGCTCTGGCTGCTAATATCGATGAGAGCAAAATTAAAGACACCGTTGATGACCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCGTCAACGGTAAAAACTACATTTATAACTATGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTTACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCACCTTGGCGTCCTATGCGCAGGTGAGCGGTAAGCTGTCTTTGGATCAAAGCGTTAGCCATTACGTTCCAGAGTTGCGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGCACGCATACCTCAGGCCTACAGCTATTTATGCCGGAAGATATTAAAAATACCACACAGCTGATGGCTTATCTAAAAGCATGGAAACCTGCCGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACTGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGAAAACCCTCCTTCCTCAGTTAGGCATGCATCACAGCTACTTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGGGAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGCGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGCTAATGCCAAGATGCAACAGGCTCTGACAGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCGGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCGCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAGCGAGTGACGGTGGCGTATAAAATCCTGAGCTCATTGGAAGGGAATAAGTAG UPDATED fmax with 3155 UPDATED accession with EF504260.2 UPDATED fmin with 1994 UPDATED strand with - UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ABP49606.1 UPDATED sequence with MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHGNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 405 UPDATE OXA-202 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-202 is a beta-lactamase found in A. baumannii. UPDATED accession with HQ734813.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1372 UPDATE ANT(2'')-Ia antibiotic inactivation; plazomicin; kanamycin A; ANT(2''); gentamicin B; gentamicin C; aminoglycoside antibiotic; tobramycin; ARO_description; model_sequences "UPDATED ARO_description with Plasmid or integron-encoded nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 2'' in P. aeruginosa, K. pneumoniae, Morganella morganii, E. coli, S. typhimurium, C. freundii and A. baumannii. UPDATED accession with AF078527.1 " 1375 UPDATE CMY-11 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-11 is a beta-lactamase found in Escherichia coli. UPDATED accession with AF357599.1 " 402 UPDATE tet(Y) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AF070999.1 " 1377 UPDATE CTX-M-60 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with AM411407.1 " 400 UPDATE PDC-1 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED accession with FJ666065.1 " 1379 UPDATE OXA-313 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-313 is a beta-lactamase found in A. baumannii. UPDATED accession with KF057030.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1378 UPDATE AAC(3)-IIc antibiotic inactivation; AAC(3); paromomycin; kanamycin A; aminoglycoside antibiotic; neomycin; butirosin; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-IIc is a plasmid-encoded aminoglycoside acetyltransferase in E. coli and P. aeruginosa. UPDATED accession with X54723.1 " 629 UPDATE VIM-28 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JF900599.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 409 UPDATE vanRL glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRL, is a vanR variant found in the vanL gene cluster. UPDATED accession with EU250284.1 UPDATED model_name with vanR gene in vanL cluster UPDATED ARO_name with vanR gene in vanL cluster " 408 UPDATE OXA-380 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF986261.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3834 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide antibiotic target alteration; prothionamide resistant katG; prothionamide; ARO_description; ARO_category "UPDATED ARO_description with Mutations in Mycobacterium tuberculosis katG conferring resistance to prothionamide, an analogue of isoniazid. UPDATED category_aro_description with Mutations associated with katG conferring resistance to prothionamide, an analogue of isoniazid. Like isoniazid, prothionamide targets lnhA. " 3836 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid isoniazid; antibiotic target alteration; isoniazid resistant ethA; ARO_description; ARO_category "UPDATED ARO_description with Mutations in Mycobacterium tuberculosis ethA conferring resistance to isoniazid. UPDATED category_aro_description with Mutations in ethA conferring resistance to isoniazid. " 628 UPDATE catB10 antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with catB10 is an integron-encoded variant of the cat gene found in P. aeruginosa. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 3830 UPDATE qacL efflux pump complex or subunit conferring antibiotic resistance; small multidrug resistance (SMR) antibiotic efflux pump; disinfecting agents and antiseptics; antibiotic efflux; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with A subunit of the qac multidrug efflux pump in Vibrio cholerae. UPDATED accession with AAZ42322.1 UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1242 UPDATE aadA6/aadA10 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA6/aadA10 is an integron-encoded aminoglycoside nucleotidyltransferase gene cassette in P. aeruginosa. UPDATED accession with AM087405.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1344 UPDATE MexH antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and antiseptics; tetracycline; ARO_category; model_name "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 UPDATED model_name with MexH " 4973 UPDATE OXA-652 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3838 UPDATE Mycobacterium tuberculosis mshA mutations conferring resistance to prothionamide antibiotic target alteration; prothionamide; prothionamide resistant mshA; ARO_description; ARO_category "UPDATED ARO_description with Mutations in Mycobacterium tuberculosis mshA conferring resistance to prothionamide, an analogue to isoniazid. UPDATED category_aro_description with Mutations in mshA conferring resistance to prothionamide, an analogue of isoniazid. " 3839 UPDATE blaS1 penam; antibiotic inactivation; mezlocillin; cefixime; blaS; cephalosporin; cephamycin; oxacillin; carbenicillin; ampicillin; piperacillin; ceftriaxone; cefoxitin; ARO_description; ARO_category "UPDATED ARO_description with Predominant beta-lactamase in Mycolicibacterium smegmatis. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with A class A beta-lactamase in Mycolicibacterium smegmatis. " 3452 UPDATE OXA-288 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4031 UPDATE PDC-183 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-183 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4033 UPDATE PDC-306 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-306 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4032 UPDATE PDC-207 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-207 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4035 UPDATE PDC-117 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-117 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 1229 UPDATE CTX-M-6 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-6 is a beta-lactamase found in Salmonella typhimurium. UPDATED accession with AJ005044.1 " 4037 UPDATE PDC-104 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-104 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 2748 UPDATE oqxAB antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; trimethoprim; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; tigecycline; glycylcycline; ciprofloxacin; tetracycline antibiotic; nitrofuran antibiotic; fluoroquinolone antibiotic; nitrofurantoin; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 4039 UPDATE PDC-292 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-292 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4038 UPDATE PDC-173 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-173 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 1228 UPDATE CMY-30 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGGTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA UPDATED fmax with 1143 UPDATED accession with EF685372.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ABS12249.1 UPDATED sequence with MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHGSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ " 4598 UPDATE EFM-1 carbapenem; antibiotic inactivation; EFM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4599 UPDATE ELM-1 carbapenem; antibiotic inactivation; ELM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 379 UPDATE OXA-148 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ853679.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 378 UPDATE TEM-214 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP050491.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2039 UPDATE CARB-18 penam; antibiotic inactivation; CARB beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ934266.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 371 UPDATE SHV-8 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with U92041.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 373 UPDATE MIR-3 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY743435.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 372 UPDATE qacA efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; major facilitator superfamily (MFS) antibiotic efflux pump; antibiotic efflux; ARO_description; model_sequences "UPDATED ARO_description with qacA is a subunit of the qac multidrug efflux pump. UPDATED accession with AB566411.1 " 375 UPDATE mdtH antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; enoxacin; ARO_description; model_sequences "UPDATED ARO_description with Multidrug resistance protein MdtH. UPDATED accession with U00096.1 " 374 UPDATE SHV-21 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF117745.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 376 UPDATE lnuC antibiotic inactivation; lincosamide nucleotidyltransferase (LNU); lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with lnuC is a transposon-mediated nucleotidyltransferase found in Streptococcus agalactiae. UPDATED accession with AY928180.1 " 4739 UPDATE KPC-80 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 393 UPDATE QnrS5 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrS5 is a plasmid-mediated quinolone resistance protein found in Aeromonas sobria. UPDATED accession with HQ631377.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 392 UPDATE TUS-1 carbapenem; antibiotic inactivation; TUS beta-lactamase; cephamycin; cephalosporin; ARO_description; model_sequences; model_name; ARO_category "UPDATED ARO_description with TUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. UPDATED accession with AF441287.1 UPDATED model_name with TUS-1 UPDATED category_aro_description with TUS beta-lactamases are Class B beta-lactamases that can hydrolyze a variety of beta-lactams, such as cephems and carbapenems. " 391 UPDATE VIM-2 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF614235.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 390 UPDATE vanSG glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSG, is a vanS variant found in the vanG gene cluster. UPDATED accession with DQ212986.1 UPDATED model_name with vanS gene in vanG cluster UPDATED ARO_name with vanS gene in vanG cluster " 397 UPDATE OXA-357 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF421160.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 396 UPDATE sul3 sulfadiazine; sulfadoxine; sulfacetamide; sulfadimidine; mafenide; sulfamethoxazole; sulfisoxazole; sulfonamide resistant sul; antibiotic target replacement; sulfamethizole; sulfasalazine; sulfonamide antibiotic; model_sequences "UPDATED accession with FJ196385.1 " 395 UPDATE blaF penam; amoxicillin; antibiotic inactivation; blaF family beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Class A beta-lactamase found in Mycolicibacterium fortuitum. UPDATED accession with L25634.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 394 UPDATE OXA-130 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-130 is a beta-lactamase found in A. baumannii. UPDATED accession with EU547445.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 399 UPDATE MIR-16 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087861.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 398 UPDATE TEM-71 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF203816.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2308 UPDATE Acinetobacter baumannii OprD conferring resistance to imipenem penam; carbapenem; imipenem; penem; reduced permeability to antibiotic; Outer Membrane Porin (Opr); cephalosporin; cephamycin; monobactam; resistance by absence; ARO_category; model_name "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). UPDATED model_name with Acinetobacter baumannii OprD conferring resistance to imipenem " 4729 UPDATE KPC-66 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4728 UPDATE KPC-65 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3960 UPDATE SHV-218 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2301 UPDATE Enterococcus faecalis YybT with mutation conferring daptomycin resistance peptide antibiotic; antibiotic target alteration; daptomycin; daptomycin resistant YybT; ARO_category "UPDATED category_aro_description with Mutations to the YybT gene confers daptomycin resistance. " 2300 UPDATE Acinetobacter baumannii ampC beta-lactamase penam; antibiotic inactivation; cephalosporin; cefepime; piperacillin; ampC-type beta-lactamase; ARO_category; model_name "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with Acinetobacter baumannii ampC beta-lactamase " 2303 UPDATE bcr-1 antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; bicyclomycin; ARO_description "UPDATED ARO_description with Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene. " 4726 UPDATE KPC-63 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4720 UPDATE KPC-44 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2307 UPDATE carO carbapenem; reduced permeability to antibiotic; resistance by absence; CarO porin; ARO_category; model_name "UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). UPDATED model_name with carO " 4722 UPDATE KPC-59 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1358 UPDATE VIM-24 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-24 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with HM855205.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1246 UPDATE AAC(2')-Ic antibiotic inactivation; AAC(2'); arbekacin; gentamicin B; gentamicin C; amikacin; aminoglycoside antibiotic; tobramycin; ARO_description "UPDATED ARO_description with AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis. " 5105 UPDATE OXA-800 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 245 UPDATE cmlA5 antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmlA5 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Escherichia coli. UPDATED accession with AY115475.1 " 244 UPDATE SHV-164 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HE981194.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 247 UPDATE TEM-158 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF534736.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 246 UPDATE CTX-M-126 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with AB703103.1 " 241 UPDATE ACT-30 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KM087833.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 240 UPDATE vanRF glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRF, is a vanR variant found in the vanF gene cluster. UPDATED accession with AF155139.1 UPDATED model_name with vanR gene in vanF cluster UPDATED ARO_name with vanR gene in vanF cluster " 243 UPDATE OXA-9 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with M55547.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 242 UPDATE SHV-152 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121119.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4628 UPDATE GES-45 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4629 UPDATE GES-46 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 249 UPDATE basS pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_description; model_sequences "UPDATED ARO_description with Histidine protein kinase sensor Lipid A modification gene; part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). UPDATED accession with JQ340365.1 " 248 UPDATE OKP-B-9 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-9 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051159.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 2274 UPDATE RlmA(II) antibiotic target alteration; non-erm 23S ribosomal RNA methyltransferase (G748); macrolide antibiotic; lincosamide antibiotic; ARO_category "UPDATED category_aro_description with Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides. " 2276 UPDATE Staphylococcus aureus ileS with mutation conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); antibiotic target alteration; mupirocin; model_sequences "UPDATED accession with X74219.1 " 2271 UPDATE Staphylococcus aureus mupB conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); antibiotic target alteration; mupirocin; model_sequences; model_name "UPDATED accession with JQ231224.1 UPDATED accession with AEY83581.1 UPDATED model_name with Staphylococcus aureus mupB conferring resistance to mupirocin " 2270 UPDATE Staphylococcus aureus mupA conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); antibiotic target alteration; mupirocin; model_sequences; model_name "UPDATED accession with X75439.1 UPDATED accession with CAA53189.1 UPDATED model_name with Staphylococcus aureus mupA conferring resistance to mupirocin " 2272 UPDATE Enterococcus faecalis cls with mutation conferring resistance to daptomycin peptide antibiotic; antibiotic target alteration; daptomycin resistant cls; daptomycin; ARO_description; model_name "UPDATED ARO_description with Cardiolipin synthase (cls) is an inner membrane protein involved in membrane synthesis and phosopholipid metabolism, with mutations to the gene being capable of conferring daptomycin resistance. UPDATED model_name with Enterococcus faecalis cls with mutation conferring resistance to daptomycin " 2278 UPDATE Bifidobacterium bifidum ileS conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); antibiotic target alteration; mupirocin; model_name "UPDATED model_name with Bifidobacterium bifidum ileS conferring resistance to mupirocin " 708 UPDATE CTX-M-49 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-49 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY847145.1 " 2154 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutations in the 3' major domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to spectinomycin. " 1248 UPDATE H-NS penam; antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; oxacillin; ciprofloxacin; tetracycline antibiotic; cloxacillin; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1071 UPDATE DHA-22 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087856.1 " 179 UPDATE QnrA5 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrA5 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. UPDATED accession with DQ058663.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 178 UPDATE vanHA vanH; glycopeptide resistance gene cluster; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; vancomycin; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanHA, is a vanH variant in the vanA gene cluster. UPDATED accession with M97297.1 UPDATED model_name with vanH gene in vanA cluster UPDATED ARO_name with vanH gene in vanA cluster " 177 UPDATE IMP-51 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with From Lahey's list of beta-lactamases, no additional information available. UPDATED accession with LC031883.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 176 UPDATE CMY-25 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-25 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with EU515249.1 " 175 UPDATE CTX-M-24 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-24 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY143430.1 " 174 UPDATE CfxA2 antibiotic inactivation; cephamycin; CfxA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with CfxA2 beta-lactamase is a class A beta-lactamase found in Prevotella intermedia. UPDATED category_aro_description with CfxA beta-lactamases are class A beta-lactamases. " 173 UPDATE arr-4 antibiotic inactivation; rifampin; rifapentine; rifabutin; rifampin ADP-ribosyltransferase (Arr); rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with arr-4 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. UPDATED accession with EF660562.1 " 171 UPDATE TEM-78 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF190693.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 170 UPDATE IMP-19 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-19 is a beta-lactamase found in Aeromonas caviae. UPDATED accession with EF118171.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2051 UPDATE dfrA15 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. UPDATED accession with KF534911.1 " 2050 UPDATE OXA-331 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203105.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2053 UPDATE dfrA7 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA7 is an integron-encoded dihydrofolate reductase found in Escherichia coli. UPDATED accession with FJ854362.1 " 2052 UPDATE APH(3'')-Ic antibiotic inactivation; APH(3''); streptomycin; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3'')-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in Mycolicibacterium fortuitum. UPDATED accession with DQ336355.1 UPDATED category_aro_description with Phosphorylation of streptomycin on the hydroxyl group at position 3''. " 2055 UPDATE LRA-3 penam; antibiotic inactivation; subclass B3 LRA beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LRA-3 is a beta-lactamase isolated from soil samples in Alaska. UPDATED accession with EU408348.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2054 UPDATE msrC quinupristin; pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; erythromycin; phenicol antibiotic; lincosamide antibiotic; model_sequences "UPDATED accession with AF313494.1 " 2057 UPDATE SHV-179 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF705208.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4829 UPDATE OXA-489 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2058 UPDATE pp-flo antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; florfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with pp-flo is a plasmid chloramphenicol exporter that is found in Photobacterium damselae subsp. piscicida. UPDATED accession with D37826.1 " 4824 UPDATE OXA-159 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4823 UPDATE OXA-114x carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4821 UPDATE OXA-114v carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 655 UPDATE OXA-243 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX206446.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4802 UPDATE OXA-114b carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 652 UPDATE tcr3 tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; ARO_description; model_sequences "UPDATED ARO_description with tcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens. UPDATED accession with D38215.1 " 4856 UPDATE OXA-521 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 653 UPDATE AAC(3)-VIIa antibiotic inactivation; AAC(3); aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-VIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces rimosus. UPDATED accession with M22999.1 " 650 UPDATE aadA antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; ARO_category "UPDATED ARO_description with ANT(3'')-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons, integrons in Enterobacteriaceae, A. baumannii, P. aeruginosa and Vibrio cholerae. UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1505 UPDATE SAT-4 streptothricin acetyltransferase (SAT); streptothricin; antibiotic inactivation; nucleoside antibiotic; model_sequences "UPDATED accession with U01945.1 " 670 UPDATE IND-3 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-3 is a beta-lactamase found in Chryseobacterium indologenes. UPDATED partial with 0 UPDATED sequence with ATGAAAAAAAGAATTCAGTTCTTTATGGTTTCAATGATGCTAAGTTCATTATTCAGTGCCCAGGTAAAAGATTTTGTCATCGAACCACCGATTAAAAAGAATTTACATATTTACAAAACTTTTGGTGTATTCGGAGGTAAAGAATATTCTGCCAATTCAGTATATCTTGTTACCCAAAAAGGAGTTGTCTTATTTGACGTCCCGTGGGAAAAGGTACAGTACCAAAGCCTGATGGATACCATCCAAAAACGCCACAATTTACCCGTAATAGCTGTGTTTGCCACTCACTCCCATGATGACCGTGCCGGAGATCTGAGCTTTTTTAACAACAAAGGAATTAAAACCTACGCTACTTCCAAAACCAATGAATTCCTGAAAAAAGACGGAAAAGCAACATCCACAGAGATCATTAAGACCGGAAAGCCATATCGCATAGGAGGTGAGGAATTTGTGGTTGATTTTCTTGGAGAAGGGCATACTGCTGATAATGTAGTGGTATGGTTTCCCAAATACAACGTCCTGGATGGCGGATGCCTTGTAAAAAGTAAAGCTGCAACCGATCTTGGATATATTAAGGAAGCCAATGTAGAGCAATGGCCCAAGACCATCAATAAACTGAAATCCAAATATTCAAAAGCAAGCCTGGTTATTCCCGGACATGATGAATGGAAAGGTGGAGGCCATGTAAAACATACTCTTGAACTTCTTAACAAAAAATAA UPDATED fmax with 720 UPDATED accession with AF219131.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Chryseobacterium indologenes UPDATED NCBI_taxonomy_id with 253 UPDATED NCBI_taxonomy_cvterm_id with 36916 UPDATED accession with AAG29761.2 UPDATED sequence with MKKRIQFFMVSMMLSSLFSAQVKDFVIEPPIKKNLHIYKTFGVFGGKEYSANSVYLVTQKGVVLFDVPWEKVQYQSLMDTIQKRHNLPVIAVFATHSHDDRAGDLSFFNNKGIKTYATSKTNEFLKKDGKATSTEIIKTGKPYRIGGEEFVVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSKAATDLGYIKEANVEQWPKTINKLKSKYSKASLVIPGHDEWKGGGHVKHTLELLNKK UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 3526 UPDATE OXA-459 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3527 UPDATE OXA-460 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3524 UPDATE OXA-457 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3525 UPDATE OXA-458 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3522 UPDATE OXA-453 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3523 UPDATE OXA-455 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3520 UPDATE OXA-451 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3521 UPDATE OXA-452 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4916 UPDATE OXA-590 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3528 UPDATE OXA-461 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3529 UPDATE OXA-464 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED NCBI_taxonomy_name with Aliarcobacter butzleri UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4655 UPDATE GOB-42 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3254 UPDATE NDM-11 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4654 UPDATE GOB-41 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 314 UPDATE TEM-176 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with GU550123.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3543 UPDATE OXA-482 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1091 UPDATE IMP-6 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-6 is a beta-lactamase found in Serratia marcescens. UPDATED accession with AB040994.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4657 UPDATE GOB-44 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 945 UPDATE tet(40) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AM419751.1 " 1977 UPDATE AAC(6')-Ik AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; model_sequences "UPDATED accession with L29510.1 " 4656 UPDATE GOB-43 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4651 UPDATE GOB-38 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2695 UPDATE MexCD-OprJ with type B NfxB mutation penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; trimethoprim; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; gentamicin C; chloramphenicol; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; model_description; ARO_category; model_name "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with MexCD-OprJ with type B NfxB mutation " 2694 UPDATE MexCD-OprJ with type A NfxB mutation penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; trimethoprim; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; tetracycline; chloramphenicol; model_description; ARO_category; model_name "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with MexCD-OprJ with type A NfxB mutation " 2693 UPDATE Type B NfxB penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; ofloxacin; trimethoprim; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; gentamicin C; chloramphenicol; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1975 UPDATE blt antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; fluoroquinolone antibiotic; disinfecting agents and antiseptics; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with blt is an MFS efflux pump that confers resistance to multiple drugs such as rhodamine and acridine dyes, and fluoroquinolone antibiotics. UPDATED accession with L32599.1 UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 2691 UPDATE Type A NfxB penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; ofloxacin; trimethoprim; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4650 UPDATE GOB-37 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4653 UPDATE GOB-40 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1973 UPDATE TEM-111 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with TEM-111 is a beta-lactamase found in E. coli and P. mirabilis. UPDATED accession with AF468003.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4983 UPDATE OXA-666 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4652 UPDATE GOB-39 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1972 UPDATE OXA-149 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ853680.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3306 UPDATE Escherichia coli ampC1 beta-lactamase penam; antibiotic inactivation; cephalosporin; ampC-type beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1971 UPDATE dfrB2 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with dfrB2 is an integron-encoded dihydrofolate reductase found in an uncultured bacterium from a wastewater treatment plant. " 1970 UPDATE SHV-44 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY259119.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1362 UPDATE IMP-31 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with KF148593.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1968 UPDATE SHV-189 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP050494.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1618 UPDATE OXA-362 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF460532.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1619 UPDATE L1 beta-lactamase antibiotic inactivation; cephalosporin; L1 family beta-lactamase; model_sequences "UPDATED accession with AJ272109.1 " 1616 UPDATE CTX-M-152 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KJ461948.1 " 1617 UPDATE vanE glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VanE is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. UPDATED accession with FJ872411.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 1614 UPDATE TEM-194 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN935136.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1615 UPDATE APH(2'')-IIa antibiotic inactivation; kanamycin A; gentamicin B; aminoglycoside antibiotic; plazomicin; sisomicin; arbekacin; APH(2''); netilmicin; gentamicin C; amikacin; isepamicin; tobramycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(2'')-IIa is a chromosomal-encoded aminoglycoside phosphotransferase in E. faecium and E. coli. UPDATED accession with AF337947.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''. " 1960 UPDATE smeB penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with smeB is the inner membrane multidrug exporter of the efflux complex smeABC in Stenotrophomonas maltophilia. UPDATED accession with AF173226.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1613 UPDATE CMY-38 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-38 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AM931008.1 " 1610 UPDATE OXA-74 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-74 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AJ854182.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1611 UPDATE SME-4 carbapenem; antibiotic inactivation; SME beta-lactamase; model_sequences "UPDATED accession with KF481967.1 " 2063 UPDATE blaR1 penam; antibiotic inactivation; BlaZ beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Alkalihalobacillus clausii UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with BlaZ beta-lactamase UPDATED category_aro_description with BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus. " 1363 UPDATE CARB-1 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-1 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AF313471.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2873 UPDATE catV antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_category "UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 2872 UPDATE PDC-93 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2871 UPDATE PDC-92 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2870 UPDATE PDC-91 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2877 UPDATE OXA-535 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2876 UPDATE OXA-436 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2874 UPDATE ACI-1 penam; antibiotic inactivation; penem; cephalosporin; cefotaxime; ceftazidime; penicillin; ticarcillin; amoxicillin; ACI beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 597 UPDATE Klebsiella pneumoniae ramR mutants penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3355 UPDATE catII from Escherichia coli K-12 antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 3357 UPDATE catA4 antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_category "UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 3356 UPDATE OXA-296 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1117 UPDATE ErmD antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with L08389.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 1745 UPDATE KPC-2 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; model_name; ARO_category "UPDATED accession with AY034847.1 UPDATED model_name with KPC-2 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3359 UPDATE Mef(En2) efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; macrolide antibiotic; antibiotic efflux; ARO_description "UPDATED ARO_description with NBU2-encoded resistance gene. An MefE homolog in Bacteroides species. Macrolide efflux MFS transporter. " 3358 UPDATE catA8 antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_category "UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1181 UPDATE cmeA antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; cefotaxime; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; fluoroquinolone antibiotic; fusidic acid; erythromycin; model_sequences "UPDATED accession with CP000768.1 " 1366 UPDATE cmx antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCCTTTTGCCCTCTACATGCTTGCCCTGGCGGTCTTCGTCATGGGCACTTCAGAATTCATGCTCGCGGGATTGCTCCCCGCGATCGCGACCGAACTTGACGTCTCGGTCGGCACTGCGGGCCTGCTGACCTCCGCATTCGCAGTCGGTATGGTCGTCGGCGCGCCAGTGATGGCGGCATTCGCTCGCCGTTGGCCACCGCGGCTCACATTGATCGTTTGCCTTCTCGTGTTCGCGGGAAGCCACGTCATCGGAGCGATGACACCAGTGTTCTCTCTCCTGCTCATCACCCGGGTGCTCAGCGCTCTCGCAAACGCAGGATTCCTCGCCGTAGCACTGAGCACGGCCACTACCCTCGTGCCAGCGAACCAGAAGGGGCGTGCACTGTCGATCCTGCTCTCCGGCACGACGATCGCAACCGTCGTGGGCGTCCCCGCCGGGGCACTGCTCGGCACAGCGCTGGGCTGGCGAACGACGTTCTGGGCGATCGCCATCCTCTGTATTCCCGCGGCCGTTGGAGTCATTCGTGGCGTCACGAACAATGTTGGTCGGAGCGAGACTAGCGCGACCTCACCAAGGCTCCGTGTCGAGCTCAGCCAGTTGGCGACGCCGCGGCTCATCCTGGCCATGGCACTCGGAGCGCTGATCAACGGAGGGACCTTTGCGGCATTCACCTTCCTGGCACCCATCGTGACCGAGACCGCGGGCTTGGCCGAAGCGTGGGTGTCCGTCGCGCTGGTGATGTTCGGCATCGGATCGTTCCTTGGCGTCACGATCGCAGGACGACTATCAGATCAACGACCTGGCCTCGTGCTCGCAGTCGGCGGACCGCTATTGCTGACAGGCTGGATCGTGTTGGCAGTGGTCGCATCTCATCCCGTTGCGCTTATCGTCCTCGTCCTCGTTCAGGGATTCCTGTCGTTCGGCGTCGGCAGTACTCTGATCACGCGTGTGCTGTATGCAGCATCGGGTGCGCCAACGATGGGCGGTTCGTACGCAACCGCAGCATTGAATATCGGAGCTGCAGCGGGGCCCGTGCTTGGTGCGCTCGGGCTCGCGACCGGGCTGGGGCTGCTCGCGCCGGTTTGGGTCGCTTCGGTGCTGACAGCGATCGCTCTCGTCATCATGCTTCTCACCAGACGCGCGCTTACGAAGACCGCGGCGGAGGCCAATTGA UPDATED fmax with 37110 UPDATED accession with AF024666.2 UPDATED fmin with 35934 UPDATED strand with + UPDATED NCBI_taxonomy_name with Corynebacterium striatum UPDATED NCBI_taxonomy_id with 43770 UPDATED NCBI_taxonomy_cvterm_id with 39554 UPDATED accession with AAG03380.1 UPDATED sequence with MPFALYMLALAVFVMGTSEFMLAGLLPAIATELDVSVGTAGLLTSAFAVGMVVGAPVMAAFARRWPPRLTLIVCLLVFAGSHVIGAMTPVFSLLLITRVLSALANAGFLAVALSTATTLVPANQKGRALSILLSGTTIATVVGVPAGALLGTALGWRTTFWAIAILCIPAAVGVIRGVTNNVGRSETSATSPRLRVELSQLATPRLILAMALGALINGGTFAAFTFLAPIVTETAGLAEAWVSVALVMFGIGSFLGVTIAGRLSDQRPGLVLAVGGPLLLTGWIVLAVVASHPVALIVLVLVQGFLSFGVGSTLITRVLYAASGAPTMGGSYATAALNIGAAAGPVLGALGLATGLGLLAPVWVASVLTAIALVIMLLTRRALTKTAAEAN " 1768 UPDATE CTX-M-144 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KJ020573.1 " 1769 UPDATE CTX-M-115 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-115 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with KJ911020.1 " 1361 UPDATE OXA-223 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-223 is a beta-lactamase found in A. baumannii. UPDATED accession with JN248564.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1762 UPDATE aadA16 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA16 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in E. coli, V. cholerae and K. pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGAGCAACGCAGTGCCCGCCGAGATTTCGGTACAGCTATCACAGGCACTCAACGTCATCGAGCGTCATCTGGGATCGACGTTGCTGGCCGTGCATTTGTACGGCTCTGCACTCGACGGTGGCCTGAAGCCATGCAGTGATATTGATTTGCTGGTTACTGTGACTGCACAGCTCGATGAGACTGTGCGGCAGGCTCTGTTCGTAGATTTCCTGGAAGTTTCCGCTTCTCCCGGCCAAAGTGAAGCTCTCCGTGCCTTGGAAGTTACCATCGTCGTGTACGGCGATGTTGCTCCTTGGCGTTATCTAGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGCAAGGACATTCTTGCGGGCATCTTCGAGCCCGCGACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGCAAGGCAACACAGCCTTGCCTTGGCAGGTTCGGCCGCGGAAGATTTCTTCAACTCAGTCCCGGAAAGCGATCTATTCAAAGCACTGGCCGACACCTTGAAACTATGGAACTCACAACCGGATTGGGCAGGCGACGAGCGGAATGTAGTGCTTACTTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCGCCGAAGGATGTAGCTGCCAACTGGGTAATGGAACGCCTGCCCGTCCAACATCAGCCCGTGCTGCTTGAAGCCCAGCAGGCTTACCTTGGACAAGGGATGGATTGCTTGGCCTCACGCGCTGATCAGTTGACTGCGTTCATTTACTTTGTGAAGCACGAAGCCGCCAGTCTGCTCGGCTCCACGCCAATGATGTCTAACAGTTCATTCAAGCCGACGCCGCTTCGCGGCGCAGCTTAA UPDATED fmax with 4042 UPDATED accession with EU675686.2 UPDATED fmin with 3196 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ACF17980.1 UPDATED sequence with MSNAVPAEISVQLSQALNVIERHLGSTLLAVHLYGSALDGGLKPCSDIDLLVTVTAQLDETVRQALFVDFLEVSASPGQSEALRALEVTIVVYGDVAPWRYLARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKARQHSLALAGSAAEDFFNSVPESDLFKALADTLKLWNSQPDWAGDERNVVLTLSRIWYSAATGKIAPKDVAANWVMERLPVQHQPVLLEAQQAYLGQGMDCLASRADQLTAFIYFVKHEAASLLGSTPMMSNSSFKPTPLRGAA UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1763 UPDATE NDM-2 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JF703135.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1760 UPDATE QnrB35 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB35 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JN173057.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1761 UPDATE OXA-351 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297580.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1766 UPDATE VIM-14 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-14 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AY635904.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1767 UPDATE OKP-A-16 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-16 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with FJ755840.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1764 UPDATE OXA-97 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-97 is a beta-lactamase found in A. baumannii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1765 UPDATE OXA-56 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-56 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AY445080.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1142 UPDATE dfrA17 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli. UPDATED accession with DQ838665.1 " 1143 UPDATE OXA-7 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with X75562.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1140 UPDATE CMY-86 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KJ207204.1 " 1141 UPDATE OXA-169 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM488990.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1146 UPDATE TEM-156 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM941159.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1147 UPDATE CMY-63 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with HQ650104.1 " 1144 UPDATE vgbB virginiamycin S2; pristinamycin IB; quinupristin; pristinamycin IC; patricin B; patricin A; ostreogrycin B3; vernamycin C; pristinamycin IA; antibiotic inactivation; streptogramin antibiotic; streptogramin vgb lyase; model_sequences; model_name; ARO_category "UPDATED accession with AF015628.1 UPDATED model_name with vgbB UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 1145 UPDATE CTX-M-124 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-124 is a beta-lactamase found in Escherichia coli. UPDATED accession with JQ429324.1 " 1148 UPDATE OXA-363 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF460533.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1149 UPDATE AER-1 AER beta-lactamase; penam; antibiotic inactivation; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with AER-1 is a beta-lactamase found in Aeromonas hydrophila. UPDATED accession with U14748.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 769 UPDATE KPC-11 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with KPC-11 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with HM066995.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 692 UPDATE TEM-159 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF136376.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 693 UPDATE OXA-22 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-22 is a beta-lactamase found in Ralstonia pickettii. UPDATED partial with 0 UPDATED sequence with ATGAAACGCCGCCACGCCGCCATCGGCGCCCTGCTTGCCGCGCTTGCCACCTTTGCCCACGCCGAGCACCCGATCTGCACGATCGTGGCCGATGCCGCCACGGGCAAGGCCGTCTTGCATGAAGGCAAGTGCGACGAGCGCGTGACGCCCGCTTCCACCTTCAAGCTGGCGCTGGCCGTCATGGGCTTCGACCACGGCTTCCTCAAAGATGAGCACACCCCGGTTGAGCACTTCAGGCACGGTGACCCCGACTGGGGCGGCGAAGCCTGGCACCAGCCGATCGACCCGGCGCTGTGGCTCAAGTATTCGGTGGTCTGGTATTCGCAGCGCATTACGCATGCGATGGGCGCGCAGACCTTCCAGGCCTACGTGCGCAAGCTTGGCTACGGCAACATGGATGTGAGCGGCGATCCGGGCAAGAACAACGGCATGGACCGCTCGTGGATCACCTCGTCGCTGAAGATTTCGCCGGAAGAGCAAGTCGGCTTGATGCGCCGGATCGTCAACCGGCAGTTGCCGGTGTCGGCGCACACCTACGAGATGCTCGACCGTACCGTGCAGACCTGGCAGGTGCCCGGCGGCTGGGCGGTGCAGGGCAAGACGGGCACTGCCGGTCCGGCGCCGGGCAACACGTCGCCCGATGGCACGTGGGATCAGGCACACGCTTACGGCTGGTTTGTCGGCTGGGCCAGGAAGGGCGACAAGACCTACGTATTCGCCAACCTGATCCAGGACGACAAGGTTGAGCCGACGTCGGGCGGTATCCGCTCGCGCGATGCGCTGTTTGCTCGCCTGTCGGAAGTGCTGGCCTTTGCTGGGCACTGA UPDATED fmax with 1776 UPDATED accession with AF064820.3 UPDATED fmin with 951 UPDATED strand with + UPDATED NCBI_taxonomy_name with Ralstonia pickettii UPDATED NCBI_taxonomy_id with 329 UPDATED NCBI_taxonomy_cvterm_id with 36921 UPDATED accession with AAD12233.1 UPDATED sequence with MKRRHAAIGALLAALATFAHAEHPICTIVADAATGKAVLHEGKCDERVTPASTFKLALAVMGFDHGFLKDEHTPVEHFRHGDPDWGGEAWHQPIDPALWLKYSVVWYSQRITHAMGAQTFQAYVRKLGYGNMDVSGDPGKNNGMDRSWITSSLKISPEEQVGLMRRIVNRQLPVSAHTYEMLDRTVQTWQVPGGWAVQGKTGTAGPAPGNTSPDGTWDQAHAYGWFVGWARKGDKTYVFANLIQDDKVEPTSGGIRSRDALFARLSEVLAFAGH UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1544 UPDATE dfrE trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis. " 691 UPDATE vanRE glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRE, is a vanR variant found in the vanE gene cluster. UPDATED accession with FJ872411.1 UPDATED model_name with vanR gene in vanE cluster UPDATED ARO_name with vanR gene in vanE cluster " 696 UPDATE cfrA dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CfrA is a chloramphenicol-florfenicol resistance gene and methyltransferase enzyme. Methylation of position 8 of A2503 in 23S rRNA confers resistance to chloramphenicol antibiotics first identified by Schwarz 2000 as cfr from Mammaliicoccus sciuri. Additional Oxazolidinone resistance mediated by the cfr gene in a human isolated was first reported from Colombia in linezolid- and methicillin-resistant Staphylococcus aureus. UPDATED accession with AM408573.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 697 UPDATE Erm(42) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with Erm42 confers MLSb phenotype in Pasteurella multocida. UPDATED accession with FR734406.1 " 694 UPDATE CTX-M-40 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description "UPDATED ARO_description with CTX-M-40 is a beta-lactamase found in Escherichia coli. " 695 UPDATE CMY-66 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JN714478.1 " 698 UPDATE TEM-205 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC900516.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 699 UPDATE QnrS9 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrS9 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. UPDATED accession with KF732714.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1548 UPDATE APH(3')-Vb antibiotic inactivation; aminoglycoside antibiotic; paromomycin; APH(3'); ribostamycin; G418; neomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-Vb is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces ribosidificus. UPDATED accession with M22126.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 1549 UPDATE ErmB antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAACAAAAATATAAAATATTCTCAAAACTTTTTAACGAGTGAAAAAGTACTCAACCAAATAATAAAACAATTGAATTTAAAAGAAACCGATACCGTTTACGAAATTGGAACAGGTAAAGGGCATTTAACGACGAAACTGGCTAAAATAAGTAAACAGGTAACGTCTATTGAATTAGACAGTCATCTATTCAACTTATCGTCAGAAAAATTAAAACTGAATACTCGTGTCACTTTAATTCACCAAGATATTCTACAGTTTCAATTCCCTAACAAACAGAGGTATAAAATTGTTGGGAGTATTCCTTACAATTTAAGCACACAAATTATTAAAAAAGTGGTTTTTGAAAGCCGTGCGTCTGACATCTATCTGATTGTTGAAGAAGGATTCTACAAGCGTACCTTGGATATTCACCGAACACTAGGGTTGCTCTTGCACACTCAAGTCTCGATTCAGCAATTGCTTAAGCTGCCAGCGGAATGCTTTCATCCTAAACCAAAAGTAAACAGTGTCTTAATAAAACTTACCCGCCATACCACAGATGTTCCAGATAAATATTGGAAGCTATATACGTACTTTGTTTCAAAATGGGTCAATCGAGAATATCGTCAACTGTTTACTAAAAATCAGTTTCATCAAGCAATGAAACACGCCAAAGTAAACAATTTAAGTACCATTACTTATGAGCAAGTATTGTCTATTTTTAATAGTTATCTATTATTTAACGGGAGGAAATTAATTCTATGA UPDATED fmax with 2878 UPDATED accession with AF242872.1 UPDATED fmin with 2131 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterococcus faecium UPDATED NCBI_taxonomy_id with 1352 UPDATED NCBI_taxonomy_cvterm_id with 36779 UPDATED accession with AAF86219.1 UPDATED sequence with MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFPNKQRYKIVGSIPYNLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRKLIL UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 543 UPDATE TEM-106 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY101578.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 540 UPDATE emrY tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with D78168.1 " 541 UPDATE TEM-133 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY528425.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 546 UPDATE TLA-1 antibiotic inactivation; monobactam; fluoroquinolone antibiotic; cephalosporin; TLA beta-lactamase; model_sequences "UPDATED accession with AF148067.1 " 547 UPDATE arr-5 antibiotic inactivation; rifampin; rifapentine; rifabutin; rifampin ADP-ribosyltransferase (Arr); rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with arr-5 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. UPDATED accession with EF660563.1 " 544 UPDATE AAC(6')-Is AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Is is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter variabilis. UPDATED accession with AF031327.1 " 545 UPDATE GES-22 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX023441.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 548 UPDATE QnrB3 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED accession with DQ303920.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 549 UPDATE TEM-107 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY101764.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 760 UPDATE TEM-6 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with X57972.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 761 UPDATE GES-13 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-13 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with GU169702.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 766 UPDATE SHV-102 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU024485.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2064 UPDATE TEM-196 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ034306.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 767 UPDATE OXA-207 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ838185.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 764 UPDATE FOX-2 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with FOX-2 is a beta-lactamase found in Escherichia coli. UPDATED accession with Y10282.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 765 UPDATE QnrB7 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB7 is a plasmid-mediated quinolone resistance protein found in Enterobacter cloacae. UPDATED partial with 0 UPDATED sequence with ATGGCTCTGGCACTCGTTGGCGAAAAAATTGACAGAAACCGTTTCACCGGTGAGAAAATTGAAAATAGTACATTTTTTAACTGTGATTTTTCAGGTGCCGACCTAAGTGGTACTGAATTTATCGGCTGTCAGTTCTATGATCGTGAAAGCCAGAAAGGGTGCAATTTTAGTCGTGCAATGCTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAATGCCAGTGCGCTGGGCATTGAAATTCGCCACTGCCGCGCACAAGGCGCAGATTTCCGCGGCGCAAGCTTTATGAATATGATCACTACACGCACCTGGTTTTGCAGCGCATATATCACTAACACAAATCTAAGCTACGCCAATTTTTCGAAAGTCGTGCTGGAAAAGTGTGAGCTGTGGGAAAACCGTTGGATGGGTGCCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTACGACTTTCGACTGGCGAGCAGCAAACTTCACACATTGCGATCTGACCAATTCGGAGTTGGGTGACTTAGATATTCGGGGCGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCATCGTTGCTCATGGAACGTCTTGGCATCGCGATTATTGGCTAG UPDATED fmax with 645 UPDATED accession with EU043311.3 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterobacter cloacae UPDATED NCBI_taxonomy_id with 550 UPDATED NCBI_taxonomy_cvterm_id with 36884 UPDATED accession with ABW03156.3 UPDATED sequence with MALALVGEKIDRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGAQVLGATFSGSDLSGGEFTTFDWRAANFTHCDLTNSELGDLDIRGVDLQGVKLDNYQASLLMERLGIAIIG UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 5137 UPDATE OXA-836 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5618 UPDATE PER-15 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5619 UPDATE PER-16 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 17 UPDATE tet(45) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; ARO_description "UPDATED ARO_description with Tet45 is a tetracycline efflux pump found in Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil. " 5613 UPDATE PER-10 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5616 UPDATE PER-13 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5617 UPDATE PER-14 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5614 UPDATE PER-11 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5615 UPDATE PER-12 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 414 UPDATE OXA-377 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF986258.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 415 UPDATE TEM-33 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with GU371926.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 416 UPDATE OXA-204 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-204 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with JQ809466.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 417 UPDATE QnrB6 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans. UPDATED accession with EF520349.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1388 UPDATE oleB oleandomycin; pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with oleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion. UPDATED accession with L36601.1 " 411 UPDATE QnrB11 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB11 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with EF653270.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 412 UPDATE OXA-117 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 413 UPDATE OXA-144 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-144 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with FJ872530.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1384 UPDATE OXA-382 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ135345.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1385 UPDATE mdsB penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; penem; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; monobactam; phenicol antibiotic; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1386 UPDATE ANT(9)-Ia antibiotic inactivation; aminoglycoside antibiotic; spectinomycin; ANT(9); ARO_description; ARO_category "UPDATED ARO_description with ANT(9)-Ia is an aminoglycoside nucleotidyltransferase encoded by plasmids and transposons in S. aureus, Enterococcus spp., Mammaliicoccus sciuri, and E. faecalis. UPDATED category_aro_description with Nucleotidylylation of spectinomycin at the hydroxyl group at position 9. " 1387 UPDATE OXA-99 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-99 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ888718.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1380 UPDATE TEM-193 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN935135.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 419 UPDATE SLB-1 penam; antibiotic inactivation; cephalosporin; SHW beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY590118.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1382 UPDATE rmtG antibiotic target alteration; aminoglycoside antibiotic; 16S rRNA methyltransferase (G1405); model_sequences "UPDATED accession with JX486113.1 " 1383 UPDATE IMI-4 carbapenem; antibiotic inactivation; IMI beta-lactamase; model_sequences "UPDATED accession with KF958750.1 " 3827 UPDATE OXA-898 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3826 UPDATE OXA-899 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3327 UPDATE AAC(2')-IIa antibiotic inactivation; aminoglycoside antibiotic; AAC(2'); kasugamycin; ARO_description "UPDATED ARO_description with AAC(2')-IIa is a kasugamycin 2' N-acetyltransferase protein found in Burkholderia glumae and Acidovorax avenae isolates. " 2769 UPDATE MdtNOP antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; puromycin; acriflavine; nucleoside antibiotic; disinfecting agents and antiseptics; ARO_description; model_description; ARO_category "UPDATED ARO_description with MdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type. UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3829 UPDATE mecC-type BlaZ penam; antibiotic inactivation; BlaZ beta-lactamase; penicillin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with A blaZ-like beta-lactamase found in S. Aureus. UPDATED partial with 0 UPDATED sequence with TTGAAAAAATTAATAATTTTAGTCGTGTTAGCGTTGATATTAAGTGCTTGTAATAGTAAGAATTCAACTAATAACGACATTGAAAAGATCGAAAAAAAATATGGTGCTAACGTAGGTATGTATGCTCTTAATACTCAAAATGGTAAAGAATTATCATTTAATGAAAATAAGCGTTTTGCATATGCTTCCACATTAAAAACTATAAGTAGCGCAATGCTGCTTGAACAAACACCTTACAACAAATTAGATAAAAAAATTCACATTAATAAAGATGATATTGTTCCATATTCACCAGTGTTAGAAAAATATATTGGCAAAGAGATAACTTTAAAAAAGCTTATAGAAGCTACCATGTTATTTAGCGATAACACGGCTAATAATAAAATTATCGATGAATTGGGAGGATATGGGCAAGTAAAAACGAAACTGATAGATTTAGGCGATACAACGACACATCCATCTAGAAAAGAACCAGACTTAAATTTTTATTCACCAAAGGATAAACGAGATACAAGTACTCCATTAGCCTATGGTAAAACTTTAAAGAAACTTATAGCTGATGGAGATCTTAGCAAAGCAAACAAAGATTTCTTACTTAATCTAATGTTCAAAAATAAAAGTGGCGATACATTAATTAAGGATGGTGCACCTTCAAACTTTAAAGTTATGGATAAGAGCGGTCAAGCACTAACATACGGTTCAAGAAACGATGTTGCGTTTGTTTATCCAGATGGACAAGATAAACCTATAATTCTGGTGATATTTACAAATAAAGATAGAAAAGATGGTAAACCTAATGACAAAATAGTAAGTGAGGTTGCTGAAATTGTACTAAAAAATATTAATGAGTAA UPDATED fmax with 1647 UPDATED accession with FR823292.1 UPDATED fmin with 795 UPDATED strand with - UPDATED NCBI_taxonomy_name with Staphylococcus aureus UPDATED NCBI_taxonomy_id with 1280 UPDATED NCBI_taxonomy_cvterm_id with 35508 UPDATED accession with CBZ41939.1 UPDATED sequence with MKKLIILVVLALILSACNSKNSTNNDIEKIEKKYGANVGMYALNTQNGKELSFNENKRFAYASTLKTISSAMLLEQTPYNKLDKKIHINKDDIVPYSPVLEKYIGKEITLKKLIEATMLFSDNTANNKIIDELGGYGQVKTKLIDLGDTTTHPSRKEPDLNFYSPKDKRDTSTPLAYGKTLKKLIADGDLSKANKDFLLNLMFKNKSGDTLIKDGAPSNFKVMDKSGQALTYGSRNDVAFVYPDGQDKPIILVIFTNKDRKDGKPNDKIVSEVAEIVLKNINE UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with BlaZ beta-lactamase UPDATED category_aro_description with BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus. " 3583 UPDATE FAR-1 penam; antibiotic inactivation; FAR beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3584 UPDATE FIM-1 carbapenem; antibiotic inactivation; cephalosporin; FIM beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCGCCCCTTACCCCATTCATACCTAAAGAGTCTTGTCATTTGCCTGCTGACGGCCTTCGCCGCCTTAACACCCGTCGTGAACTCTGGCGTACAAGCGGCTCAACCCAAAGACGTGCCGGTAACGTTTACCGCTATTACGCAGGGGGTGTGGATGCACACCAGCATGAAGCACATGGAAAACTGGGGGCATGTACCCAGTAACGGGCTAATCGTTGAAAAAGGAGACTTTAGTATTTTGGTGGATACGGCTTGGGACGATCCACAAACGGCACAGATTATTGAGTGGTCCAAAGATACGCTAAAAAAACCCATTCGTTGGGCGGTGTTTACCCATGCCCACGACGACAAAATGGGCGGGGTGGCTGCCTTACGACAGCAGGGCATTGTGACCTATGCGGCGGCCGACTCTAATCGAATGGCCCCACAGAATGGCTTAACCCCTGCAGAGCATGACCTCATCTTTGATAGCGAGCACAGCACAAGCGTTCTGCATCCGCTGGTCATTTTCGATCCCGGCCCAGGGCATACCCGCGACAATATTGTGGTGGGCCTGCCCGAGCAAGGGATTGTTTTTGGAGGCTGTCTCATTCGCCCATCGGGCAGCACGTCTCTGGGAAACACCGCTGACGCCGATCTCGCTCACTGGAAAACAGCGGTATTGGCCGTTGCGCAGCGCTTTGCGGAGGCCCAACAGATTATACCCAGCCACGGACCCATGGCCGGACGAGAGCTTTTTGAACTGACGGCTCAGCTGGCAGAAAAGGCCAGCATACCGTCCACACCCTGA UPDATED fmax with 2725 UPDATED accession with JX570731.1 UPDATED fmin with 1936 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AFV91534.1 UPDATED sequence with MRPLPHSYLKSLVICLLTAFAALTPVVNSGVQAAQPKDVPVTFTAITQGVWMHTSMKHMENWGHVPSNGLIVEKGDFSILVDTAWDDPQTAQIIEWSKDTLKKPIRWAVFTHAHDDKMGGVAALRQQGIVTYAAADSNRMAPQNGLTPAEHDLIFDSEHSTSVLHPLVIFDPGPGHTRDNIVVGLPEQGIVFGGCLIRPSGSTSLGNTADADLAHWKTAVLAVAQRFAEAQQIIPSHGPMAGRELFELTAQLAEKASIPSTP " 5006 UPDATE OXA-694 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3588 UPDATE FONA-4 penam; antibiotic inactivation; FONA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 368 UPDATE CARB-14 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-14 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with JQ364968.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 369 UPDATE SHV-15 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAATGCTGGCGCGGGTGGATGCCGGTGACAAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTAGCAAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AJ011428.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with CAB37325.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAMLARVDAGDKQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 366 UPDATE Mycobacterium tuberculosis iniA mutant conferring resistance to Ethambutol antibiotic efflux; polyamine antibiotic; Ethambutol resistant iniA; efflux pump complex or subunit conferring antibiotic resistance; ethambutol; antibiotic target alteration; ARO_description; ARO_name; model_sequences; model_name; ARO_category "UPDATED ARO_description with Specific mutations in Mycobacterium tuberculosis iniA resulting in resistance to ethambutol. UPDATED ARO_name with Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol UPDATED accession with AL123456.1 UPDATED model_name with Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol UPDATED category_aro_description with Mutations that occurs on the iniA genes resulting in the resistance to ethambutol. " 367 UPDATE CTX-M-25 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-25 is a beta-lactamase found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGATGAGAAAAAGCGTAAGGCGGGCGATGTTAATGACGACAGCCTGTGTTTCGCTGCTGTTGGCCAGTGTGCCGCTGTGTGCCCAGGCGAACGATGTTCAACAAAAGCTCGCGGCGCTGGAGAAAAGCAGCGGGGGACGACTGGGTGTGGCGTTGATTAACACCGCCGATAACACGCAGACGCTCTACCGCGCCGACGAGCGTTTTGCCATGTGCAGCACCAGTAAAGTGATGGCGGTAGCGGCGGTGCTTAAGCAAAGTGAAACGCAAAAGGGCTTGTTGAGTCAGCGGGTTGAAATTAAGCCCTCAGACTTGATTAACTACAACCCCATTGCGGAAAAACACGTCAATGGCACGATGACATTCGGGGAGTTGAGCGCGGCGGCGCTACAGTACAGCGATAATACTGCCATGAATAAGCTGATTGCCCATCTCGGGGGGCCGGATAAAGTGACGGCATTTGCCCGTACGATTGGCGATGACACGTTCCGGCTCGATCGTACCGAGCCGACGCTCAACACCGCGATCCCCGGCGACCCGCGCGATACCACCACGCCGTTAGCGATGGCGCAGGCTCTGCGCAATCTGACGTTGGGCAATGCCCTGGGTGACACTCAGCGTGCGCAGCTGGTGATGTGGCTGAAAGGCAACACCACCGGCGCTGCCAGCATTCAGGCAGGGCTACCCACATCGTGGGTTGTCGGGGATAAAACCGGCAGCGGCGGTTATGGTACGACGAATGATATCGCGGTTATTTGGCCGGAAGGTCGCGCGCCGCTCGTTCTGGTGACTTACTTCACCCAGTCGGAGCCGAAGGCAGAGAGCCGTCGTGACGTGCTCGCTGCTGCCGCCAGAATTGTCACCGACGGTTATTAA UPDATED fmax with 3196 UPDATED accession with AF518567.2 UPDATED fmin with 2320 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAM70498.1 UPDATED sequence with MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEIKPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY " 364 UPDATE CMY-83 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JX440351.1 " 365 UPDATE TEM-122 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY307100.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 362 UPDATE CTX-M-151 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with AB916359.1 " 363 UPDATE TEM-155 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ679961.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 360 UPDATE AAC(6')-Iy AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; model_sequences "UPDATED accession with AF144880.1 " 361 UPDATE OXA-278 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-278 is a beta-lactamase found in A. baumannii. UPDATED accession with KC771279.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5008 UPDATE OXA-696 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1431 UPDATE GES-15 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with GU208678.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 380 UPDATE CTX-M-147 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KF513180.1 " 381 UPDATE QnrS1 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; ARO_category "UPDATED ARO_description with QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri. UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 382 UPDATE QnrB61 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB61 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. UPDATED accession with AB734053.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 383 UPDATE Pseudomonas mutant PhoQ conferring resistance to colistin antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; pmr phosphoethanolamine transferase; colistin A; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; erythromycin; ARO_description "UPDATED ARO_description with Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. " 384 UPDATE APH(2'')-IVa antibiotic inactivation; kanamycin A; gentamicin B; aminoglycoside antibiotic; sisomicin; arbekacin; APH(2''); netilmicin; gentamicin C; amikacin; isepamicin; tobramycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(2'')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in E. casseliflavus. UPDATED accession with AF016483.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''. " 385 UPDATE OXA-46 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-46 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with JX131372.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 386 UPDATE LEN-8 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with LEN-8 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 387 UPDATE mdtA efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; aminocoumarin antibiotic; resistance-nodulation-cell division (RND) antibiotic efflux pump; novobiocin; model_sequences "UPDATED accession with U00096.1 " 388 UPDATE QnrB71 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB71 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. UPDATED accession with KC580660.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4758 UPDATE LUT-5 antibiotic inactivation; LUT beta-lactamase; cephalosporin; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4759 UPDATE LUT-6 antibiotic inactivation; LUT beta-lactamase; cephalosporin; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 2065 UPDATE CMY-5 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description "UPDATED ARO_description with CMY-5 is a beta-lactamase found in Klebsiella oxytoca. " 1369 UPDATE QnrB69 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB69 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with KC580658.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4753 UPDATE LUS-1 LUS beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4755 UPDATE LUT-2 antibiotic inactivation; LUT beta-lactamase; cephalosporin; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4757 UPDATE LUT-4 antibiotic inactivation; LUT beta-lactamase; cephalosporin; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1076 UPDATE IMP-37 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with JX131372.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1077 UPDATE OXA-420 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB983359.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1074 UPDATE LEN-3 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences; ARO_category "UPDATED accession with AY130286.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 797 UPDATE TEM-55 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ286729.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3759 UPDATE APH(3')-VIb antibiotic inactivation; aminoglycoside antibiotic; isepamicin; paromomycin; kanamycin A; APH(3'); gentamicin B; amikacin; ribostamycin; G418; neomycin; butirosin; ARO_description; ARO_category "UPDATED ARO_description with APH(3')-VIb is a plasmid-encoded aminoglycoside phosphotransferase in K. pneumoniae and S. marcescens. UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 1075 UPDATE TEM-20 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y17581.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3751 UPDATE TEM-181 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3750 UPDATE tet(57) tetracycline antibiotic; tetracycline-resistant ribosomal protection protein; antibiotic target protection; ARO_description "UPDATED ARO_description with A tetracycline efflux MFS Transporter from Providencia sp. Y14. " 3753 UPDATE TxR antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; tetracycline; model_name "UPDATED model_name with TxR " 3755 UPDATE qacEdelta1 efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; disinfecting agents and antiseptics; antibiotic efflux; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3754 UPDATE qacE efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; disinfecting agents and antiseptics; antibiotic efflux; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3757 UPDATE IDC-2 carbapenem; antibiotic inactivation; cephalosporin; IDC beta-lactamase; ARO_description "UPDATED ARO_description with IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. " 3756 UPDATE IDC-1 carbapenem; antibiotic inactivation; cephalosporin; IDC beta-lactamase; ARO_description "UPDATED ARO_description with IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. " 4633 UPDATE GOB-20 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2191 UPDATE AAC(6')-Iaj AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iaj is a functional acetyltransferase that modifies the amino groups at the 6' positions of aminoglycosides and contributes to aminoglycoside resistance of P. aeruginosa. UPDATED accession with AB709942.1 " 258 UPDATE OXA-208 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with FR853176.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2193 UPDATE TriB efflux pump complex or subunit conferring antibiotic resistance; triclosan; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2194 UPDATE TriC efflux pump complex or subunit conferring antibiotic resistance; triclosan; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2195 UPDATE OpmH efflux pump complex or subunit conferring antibiotic resistance; triclosan; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 4634 UPDATE GOB-21 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 253 UPDATE vanXYG glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanXY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXYG, is a vanXY variant found in the vanG gene cluster. UPDATED accession with DQ212986.1 UPDATED model_name with vanXY gene in vanG cluster UPDATED ARO_name with vanXY gene in vanG cluster " 250 UPDATE Rhodococcus fascians cmr antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmr is a plasmid-encoded chloramphenicol exporter that is found in Rhodococcus fascians and Corynebacterium glutamicum. UPDATED accession with Z12001.1 " 251 UPDATE APH(3')-VIIa antibiotic inactivation; kanamycin A; APH(3'); aminoglycoside antibiotic; G418; neomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-VIIa is a plasmid-encoded aminoglycoside phosphotransferase in C. jejuni. UPDATED accession with M29953.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 256 UPDATE CMY-21 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-21 is a beta-lactamase found in Escherichia coli. UPDATED accession with DQ139328.1 " 257 UPDATE ACT-37 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KM926622.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 254 UPDATE OXA-150 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ853681.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 255 UPDATE BRP(MBL) antibiotic inactivation; bleomycin B2; bleomycinic acid; bleomycin A2; Bleomycin resistant protein; glycopeptide antibiotic; model_name "UPDATED model_name with BRP(MBL) " 2200 UPDATE APH(3')-VI antibiotic inactivation; aminoglycoside antibiotic; isepamicin; paromomycin; kanamycin A; APH(3'); gentamicin B; amikacin; ribostamycin; G418; neomycin; butirosin; ARO_category "UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 2201 UPDATE PvrR phenotypic variant regulator; resistance by absence; aminoglycoside antibiotic; ARO_description; ARO_category "UPDATED ARO_description with PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence. UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). " 2202 UPDATE AAC(3)-Ib/AAC(6')-Ib'' antibiotic inactivation; AAC(3); AAC(6'); kanamycin A; gentamicin C; aminoglycoside antibiotic; tobramycin; ARO_description; model_param "UPDATED ARO_description with AAC(3)-Ib/AAC(6')-Ib'' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED param_description with A parameter to describe the genes in a fusion protein. The parameter is defined by Cvterm IDs, separated by commas, with the ordering number preceding a colon. If the ordering of one or more parameters is unknown, it is designated as 0. Examples: 1:30003,2:30111 or 0:32224,0:33555. " 2203 UPDATE MCR-1.1 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; model_sequences; model_name "UPDATED accession with KP347127.1 UPDATED accession with AKF16168.1 UPDATED model_name with MCR-1.1 " 2205 UPDATE MexJ antibiotic efflux; triclosan; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; disinfecting agents and antiseptics; tetracycline; erythromycin; ARO_description; ARO_category; model_name "UPDATED ARO_description with MexJ is the membrane fusion protein of the MexJK multidrug efflux protein. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED model_name with MexJ " 2206 UPDATE MexK antibiotic efflux; triclosan; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; disinfecting agents and antiseptics; tetracycline; erythromycin; ARO_description; ARO_category; model_name "UPDATED ARO_description with MexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED model_name with MexK " 2207 UPDATE MexV antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category; model_name "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 UPDATED model_name with MexV " 2208 UPDATE MexW antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category; model_name "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 UPDATED model_name with MexW " 3985 UPDATE TEM-210 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with TEM-210. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4812 UPDATE OXA-114l carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2424 UPDATE YojI peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; microcin J25; antibiotic efflux; ARO_category; model_name "UPDATED category_aro_description with Microcin J25 is a peptide antibiotic that inhibits transcription by bacterial RNA polymerase. MccJ25 is produced by Escherichia coli strains that harbor a plasmid-borne antibiotic-synthesis and antibiotic-export cassette, consisting of a gene for MccJ25 precursor (a 58 residue linear peptide), two genes for factors that process MccJ25 precursor into MccJ25, and one gene for export of MccJ25. UPDATED model_name with YojI " 2425 UPDATE hmrM antibiotic efflux; norfloxacin; multidrug and toxic compound extrusion (MATE) transporter; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; fluoroquinolone antibiotic; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 4810 UPDATE OXA-114j carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 168 UPDATE VIM-17 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-17 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATGATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG UPDATED fmax with 1811 UPDATED accession with EU118148.2 UPDATED fmin with 1010 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with ABW90721.1 UPDATED sequence with MFKLLSKLLVYLTASMMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 169 UPDATE IMP-33 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-33 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGAAGAAATTATTTGTTTTATGTGTATGCTTCTTTTGTAGCATTACTGCCGCAGGATCGTCTTTACCTGATTTAAAAATTGAGAAGCTTGAAGAAGGTGTTTTTGTTCATACATCGTTCGAAGAAGTTAACGGTTGGGGGGTTGTTACTAAACACGGTTTGGTGGTGCTTGTAAACACAGACGCCTATCTAATTGACACTCCATTTACTGCTACAGACACTGAAAAATTAGTCAATTGGTTTGTGGAGCGCGGCTATAAAATCAAAGGCACTATTTCATCACATTTCCATAGCGACAGCACAGGAGGAATAGAGTGGCTTAATTCTCAATCTATTCCCACGTATGCATCTGAATTAACAAATGAACTTTTGAAAAAATCCGGTAAGGTACAAGCTAAATATTCATTTAGCGAAGTTAGCTATTGGCTAGTTAAAAATAAAATTGAAGTTTTTTATCCTGGCCCAGGTCACACTCAAGATAACCTAGTGGTTTGGTTGCCTGAAAGTAAAATTTTATTCGGTGGTTGCTTTGTTAAACCTCACGGTCTTGGCAATTTAGGTGACGCAAATTTAGAAGCTTGGCCAAAGTCCGCCAAAATATTAATGTCTAAATATGGCAAAGCAAAGCTTGTTGTTTCAAGTCATAGTGAGAAAGGGGACGCATCACTATTGAAACGTACATGGGAACAAGCTCTTAAAGGGCTTAAAGAAAGTAAAAAAACATCATCACCAAGTAACTAA UPDATED fmax with 2568 UPDATED accession with JN848782.2 UPDATED fmin with 1827 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AEU17778.1 UPDATED sequence with MKKLFVLCVCFFCSITAAGSSLPDLKIEKLEEGVFVHTSFEEVNGWGVVTKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKSGKVQAKYSFSEVSYWLVKNKIEVFYPGPGHTQDNLVVWLPESKILFGGCFVKPHGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEKGDASLLKRTWEQALKGLKESKKTSSPSN UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 164 UPDATE vanN glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecium. UPDATED accession with JF802084.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 165 UPDATE VIM-29 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-29 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with JX311308.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 268 UPDATE CfxA6 antibiotic inactivation; cephamycin; CfxA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CfxA6 beta-lactamase is a class A beta-lactamase found in an uncultured bacterium. UPDATED accession with GQ342996.1 UPDATED category_aro_description with CfxA beta-lactamases are class A beta-lactamases. " 167 UPDATE CMY-39 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with AB372224.1 " 160 UPDATE OXA-236 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-236 is a beta-lactamase found in A. baumannii. UPDATED accession with JQ820242.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 161 UPDATE SHV-56 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU586041.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 162 UPDATE KPC-8 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with KPC-8 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with FJ234412.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 163 UPDATE OXA-376 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF986257.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4839 UPDATE OXA-504 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4838 UPDATE OXA-503 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4815 UPDATE OXA-114p carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4831 UPDATE OXA-493 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2518 UPDATE tetB(58) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_name "UPDATED model_name with tetB(58) " 4423 UPDATE CARB-38 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2066 UPDATE Escherichia coli soxS with mutation conferring antibiotic resistance penem; antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; reduced permeability to antibiotic; carbapenem; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; tigecycline; glycylcycline; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2517 UPDATE tetA(58) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_name "UPDATED model_name with tetA(58) " 908 UPDATE CTX-M-139 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KC107824.1 " 2734 UPDATE PmpM antibiotic efflux; chlorhexidine; multidrug and toxic compound extrusion (MATE) transporter; efflux pump complex or subunit conferring antibiotic resistance; benzalkonium chloride; fluoroquinolone antibiotic; aminoglycoside antibiotic; disinfecting agents and antiseptics; neomycin; ARO_category "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with chlorhexidine UPDATED category_aro_cvterm_id with 45598 UPDATED category_aro_accession with 3007039 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate). UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 909 UPDATE OXA-5 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with X58272.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2731 UPDATE MexJK-OpmH efflux pump complex or subunit conferring antibiotic resistance; triclosan; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; disinfecting agents and antiseptics; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2732 UPDATE MexVW-OprM antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; tetracycline; chloramphenicol; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 2733 UPDATE TriABC-OpmH efflux pump complex or subunit conferring antibiotic resistance; triclosan; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; disinfecting agents and antiseptics; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1846 UPDATE CTX-M-91 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-91 is a beta-lactamase found in Escherichia coli. UPDATED accession with GQ870432.1 " 3531 UPDATE OXA-466 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3530 UPDATE OXA-465 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3533 UPDATE OXA-471 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3532 UPDATE OXA-470 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5058 UPDATE OXA-749 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5059 UPDATE OXA-750 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3537 UPDATE OXA-475 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3536 UPDATE OXA-474 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3539 UPDATE OXA-477 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3538 UPDATE OXA-476 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5056 UPDATE OXA-747 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5057 UPDATE OXA-748 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5050 UPDATE OXA-741 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5051 UPDATE OXA-742 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5052 UPDATE OXA-743 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5053 UPDATE OXA-744 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1814 UPDATE AAC(6')-Ie-APH(2'')-Ia antibiotic inactivation; kanamycin A; gentamicin B; AAC(6'); aminoglycoside antibiotic; plazomicin; sisomicin; arbekacin; APH(2''); netilmicin; gentamicin C; amikacin; isepamicin; tobramycin; ARO_description; ARO_category "UPDATED ARO_description with AAC(6')-Ie-APH(2'')-Ia is an aminoglycoside acetyltransferase encoded by plasmids and transposons in S. aureus, E. faecalis, E. faecium and Staphylococcus warneri. UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''. " 1815 UPDATE CTX-M-134 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JX896165.1 " 1816 UPDATE TEM-8 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with X65252.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1817 UPDATE vgaB dalfopristin; pleuromutilin; virginiamycin M1; pleuromutilin antibiotic; madumycin II; griseoviridin; ABC-F ATP-binding cassette ribosomal protection protein; macrolide antibiotic; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCTTAAAATCGACATGAAGAATGTAAAAAAATATTATGCAGATAAATTAATTTTAAATATAAAAGAACTAAAGATTTATAGTGGGGATAAAATAGGTATTGTAGGTAAGAATGGAGTTGGCAAAACAACACTTTTAAAAATAATAAAAGGACTAATAGAGATTGACGAAGGAAATATAATTATAAGTGAAAAAACAACTATTAAATATATCTCTCAATTAGAAGAACCACATAGTAAGATAATTGATGGAAAATATGCTTCAATATTTCAAGTTGAAAATAAGTGGAATGACAATATGAGTGGTGGTGAAAAAACTAGATTTAAACTAGCAGAGGGATTTCAAGATCAATGTTCTTTAATGCTCGTAGATGAACCTACAAGTAATTTAGATATCGAAGGAATAGAGTTGATAACAAATACTTTTAAAGAGTACCGTGATACTTTTTTGGTAGTATCTCATGATAGAATTTTTTTAGATCAAGTTTGTACAAAAATTTTTGAAATTGAAAATGGATATATTAGAGAATTCATCGGTAATTATACAAACTATATAGAGCAAAAAGAAATGCTTCTACGAAAGCAACAAGAAGAATACGAAAAGTATAATTCTAAAAGAAAGCAATTGGAGCAAGCTATAAAGCTAAAAGAGAATAAGGCGCAAGGAATGATTAAGCCCCCTTCAAAAACAATGGGAACATCTGAATCTAGAATATGGAAAATGCAACATGCTACTAAACAAAAAAAGATGCATAGAAATACGAAATCGTTGGAAACACGAATAGATAAATTAAATCATGTAGAAAAAATAAAAGAGCTTCCTTCTATTAAAATGGATTTACCTAATAGAGAGCAATTTCATGGTCGCAATGTAATTAGTTTAAAAAACTTATCTATAAAATTTAATAATCAATTTCTTTGGAGAGATGCTTCATTTGTCATTAAAGGTGGAGAAAAGGTTGCTATAATTGGTAACAATGGTGTAGGAAAAACAACATTGTTGAAGCTGATTCTAGAAAAAGTAGAATCAGTAATAATATCACCATCAGTTAAAATTGGATACGTCAGTCAAAACTTAGATGTTCTACAATCTCATAAATCTATCTTAGAAAATGTTATGTCTACCTCCATTCAAGATGAAACAATAGCAAGAATTGTTCTAGCAAGATTACATTTTTATCGCAATGATGTTCATAAAGAAATAAATGTTTTGAGTGGTGGAGAACAAATAAAGGTTGCTTTTGCCAAGCTATTTGTTAGCGATTGTAATACATTAATTCTTGATGAACCAACAAACTATTTGGATATCGATGCTGTTGAGGCATTAGAAGAATTGTTAATTACCTATGAAGGTGTTGTGTTATTTGCTTCCCATGATAAAAAATTTATACAAAACCTAGCTGAACAATTGTTAATAATAGAAAATAATAAAGTGAAAAAATTCGAAGGAACATATATAGAATATTTAAAAATTAAAGATAAACCAAAATTAAATACAAATGAAAAAGAACTCAAAGAAAAAAAGATGATACTAGAAATGCAAATTTCATCATTATTAAGTAAAATCTCAATGGAAGAAAATGAAGAAAAAAACAAAGAATTAGATGAAAAGTACAAATTGAAATTAAAAGAATTGAAAAGCCTAAATAAAAATATTTAA UPDATED fmax with 2287 UPDATED accession with U82085.2 UPDATED fmin with 628 UPDATED strand with + UPDATED NCBI_taxonomy_name with Staphylococcus aureus UPDATED NCBI_taxonomy_id with 1280 UPDATED NCBI_taxonomy_cvterm_id with 35508 UPDATED accession with AAB95639.1 UPDATED sequence with MLKIDMKNVKKYYADKLILNIKELKIYSGDKIGIVGKNGVGKTTLLKIIKGLIEIDEGNIIISEKTTIKYISQLEEPHSKIIDGKYASIFQVENKWNDNMSGGEKTRFKLAEGFQDQCSLMLVDEPTSNLDIEGIELITNTFKEYRDTFLVVSHDRIFLDQVCTKIFEIENGYIREFIGNYTNYIEQKEMLLRKQQEEYEKYNSKRKQLEQAIKLKENKAQGMIKPPSKTMGTSESRIWKMQHATKQKKMHRNTKSLETRIDKLNHVEKIKELPSIKMDLPNREQFHGRNVISLKNLSIKFNNQFLWRDASFVIKGGEKVAIIGNNGVGKTTLLKLILEKVESVIISPSVKIGYVSQNLDVLQSHKSILENVMSTSIQDETIARIVLARLHFYRNDVHKEINVLSGGEQIKVAFAKLFVSDCNTLILDEPTNYLDIDAVEALEELLITYEGVVLFASHDKKFIQNLAEQLLIIENNKVKKFEGTYIEYLKIKDKPKLNTNEKELKEKKMILEMQISSLLSKISMEENEEKNKELDEKYKLKLKELKSLNKNI UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 1810 UPDATE VIM-15 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-15 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with EU419745.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1811 UPDATE CARB-2 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-2 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with DQ157752.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1812 UPDATE KHM-1 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; KHM beta-lactamase; model_sequences; model_name; ARO_category "UPDATED accession with AB364006.1 UPDATED model_name with KHM-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1813 UPDATE MOX-4 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with MOX-4 is a beta-lactamase found in Aeromonas caviae. UPDATED accession with FJ262599.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1093 UPDATE AAC(6')-31 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-31 is an integron-encoded aminoglycoside acetyltransferase in Pseudomonas putida, A. baumannii and K. pneumoniae. UPDATED accession with AM283489.1 " 1818 UPDATE GES-26 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP096411.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1819 UPDATE TEM-3 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4912 UPDATE OXA-586 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 674 UPDATE OXA-15 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with U63835.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 300 UPDATE AAC(6')-29a AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(6')-29a is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. " 675 UPDATE OXA-25 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-25 is a beta-lactamase found in A. baumannii. UPDATED accession with AF201826.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 725 UPDATE GES-11 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-11 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with FJ854362.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 676 UPDATE AAC(6')-Ih AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ih is a plasmid-encoded aminoglycoside acetyltransferase in A. baumannii. UPDATED accession with L29044.1 " 677 UPDATE OXA-171 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM488992.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2008 UPDATE SHV-145 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX013655.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1087 UPDATE OXA-253 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-253 is a beta-lactamase found in A. baumannii. UPDATED partial with 0 UPDATED sequence with ATGAAAAAATTTATACTTCCTATCTTCAGCATTTCTATTCTACTTTCTCTCAGTGCATGCTCATCTATTCAAACTAAATTTGAAGATACTTCTGATATTTCTGATCAGCAACAAGGAAAAGCCATTAAAAGCTATTTTGATGAAGCTCAAACACAAGGTGTAATCATTATTAAAGAGGGAAAGAATATTAGTACCTATGGTAATAACCTGGCACGAGCACATACAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCCTTAATTGGATTAGAAAATCATAAAGCTACAACAACTGAGATTTTCAAATGGGATGGTAAAAAAAGATCTTATCCTATGTGGGAAAAAGATATGACTTTAGGTGATGCCATGGCACTTTCAGCAGTTCCTGTATATCAAGAACTTGCAAGACGGACTGGTTTAGACCTAATGCAAAAAGAAGTCAAACGGGTTGGTTTTGGTAATATGAACATTGGAACACAAGTTGATAACTTCTGGTTGGTTGGCCCGCTTAAAATTACACCAATACAAGAGGTTAATTTTGCCGACGATCTCGCTAATAATCGATTACCCTTTAAATTAGAAACTCAAGAAGAAGTAAAAAAAATGCTTCTGATTAAAGAAGTCAATGGTAGTAAAATTTATGCGAAAAGCGGATGGGGAATGGATGTAATCCCTCAGGTAGGTTGGTTAACAGGTTGGGTAGAAAAATCTAATGGCGAAAAAGTTCCCTTTTCTCTAAACCTAGAAATGAAGCAAGGAATGTCTGGTTCTATTCGTAATGAAATTACTTATAAGTCATTAGAAAATTTAGGGATTATATAG UPDATED fmax with 1403 UPDATED accession with KC479324.2 UPDATED fmin with 575 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with AGK07368.1 UPDATED sequence with MKKFILPIFSISILLSLSACSSIQTKFEDTSDISDQQQGKAIKSYFDEAQTQGVIIIKEGKNISTYGNNLARAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEKDMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMNIGTQVDNFWLVGPLKITPIQEVNFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVIPQVGWLTGWVEKSNGEKVPFSLNLEMKQGMSGSIRNEITYKSLENLGII UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2795 UPDATE MCR-3.1 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; model_name "UPDATED model_name with MCR-3.1 " 671 UPDATE CTX-M-137 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-137 is a beta-lactamase found in Escherichia coli. UPDATED accession with AB900900.1 " 672 UPDATE CMY-27 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-27 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with EU515250.1 " 673 UPDATE IMP-48 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with KM087857.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1609 UPDATE QnrC sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrC is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. UPDATED accession with EU917444.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1979 UPDATE FosA4 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; ARO_description; model_sequences "UPDATED ARO_description with FosA4 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. UPDATED accession with AB908992.1 " 1978 UPDATE OXA-200 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-200 is a beta-lactamase found in A. baumannii. UPDATED accession with HQ734811.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1601 UPDATE LRA-1 class A LRA beta-lactamase; penam; cephalosporin; antibiotic inactivation; ARO_description; ARO_category "UPDATED ARO_description with LRA-1 is a beta-lactamase isolated from soil samples in Alaska. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1603 UPDATE SHV-86 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ328802.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1602 UPDATE AAC(6')-Iai AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iai is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. UPDATED accession with EU886977.1 " 1605 UPDATE cphA5 carbapenem; CphA beta-lactamase; antibiotic inactivation; model_sequences "UPDATED accession with AY227051.1 " 1604 UPDATE CTX-M-84 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-84 is a beta-lactamase found in Salmonella enterica. UPDATED accession with FJ214367.1 " 1607 UPDATE Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin penam; cephamycin; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; amoxicillin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae. UPDATED accession with JN645776.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. " 1606 UPDATE CTX-M-16 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-16 is a beta-lactamase found in Escherichia coli. UPDATED accession with AY029068.1 " 1555 UPDATE SHV-140 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN051143.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 809 UPDATE lnuB antibiotic inactivation; lincosamide nucleotidyltransferase (LNU); lincosamide antibiotic; ARO_description "UPDATED ARO_description with lnuB is a plasmid-mediated nucleotidyltransferase found in Streptococcus lutetiensis. " 808 UPDATE TEM-171 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ149347.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 803 UPDATE cphA4 carbapenem; CphA beta-lactamase; antibiotic inactivation; model_sequences "UPDATED accession with AY227050.1 " 802 UPDATE QnrA3 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrA3 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. UPDATED accession with DQ058661.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 801 UPDATE mfpA sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis. UPDATED accession with AL123456.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 800 UPDATE CTX-M-87 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-87 is a beta-lactamase found in Escherichia coli. UPDATED accession with EU545409.1 " 807 UPDATE OKP-B-1 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAGGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCATGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCCGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGTTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGGGATACCGCGGCGACCATGGCCGAACGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAG UPDATED fmax with 861 UPDATED accession with AJ635402.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAG25813.2 UPDATED sequence with MRYVRLCLISLIAALPLAVFASPQPLEQIKISEGQLAGRVGYVEMDLASGRMLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTAATMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 806 UPDATE SHV-150 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121117.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 805 UPDATE MexC penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; trimethoprim; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; gentamicin C; chloramphenicol; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; model_sequences; ARO_category "UPDATED accession with U57969.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 804 UPDATE tetB(P) chlortetracycline; demeclocycline; oxytetracycline; tetracycline antibiotic; tetracycline; antibiotic target protection; minocycline; tetracycline-resistant ribosomal protection protein; doxycycline; model_sequences "UPDATED accession with L20800.1 " 4437 UPDATE CARB-53 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2848 UPDATE MCR-4.1 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; model_name "UPDATED model_name with MCR-4.1 " 2849 UPDATE MCR-5.1 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; model_name "UPDATED model_name with MCR-5.1 " 2844 UPDATE Rhodobacter sphaeroides ampC beta-lactamase penam; antibiotic inactivation; benzylpenicillin; ampC-type beta-lactamase; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Cereibacter sphaeroides 2.4.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2845 UPDATE Laribacter hongkongensis ampC beta-lactamase penam; antibiotic inactivation; cephalosporin; ampC-type beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2842 UPDATE Vibrio cholerae varG carbapenem; antibiotic inactivation; Subclass B1 Vibrio cholerae varG beta-lactamase; meropenem; ARO_category "UPDATED category_aro_name with Subclass B1 Vibrio cholerae varG beta-lactamase " 2843 UPDATE Escherichia coli ampC beta-lactamase penam; penicillin; cephalosporin; antibiotic inactivation; ampC-type beta-lactamase; ARO_category; model_name "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with Escherichia coli ampC beta-lactamase " 2840 UPDATE NPS-1 penam; antibiotic inactivation; NPS beta-lactamase; cephalosporin; model_sequences; ARO_category "UPDATED accession with AY027589.1 UPDATED accession with AAK14791.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2841 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to chloramphenicol antibiotic target alteration; phenicol antibiotic; 23S rRNA with mutation conferring resistance to phenicol antibiotics; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to chloramphenicol. UPDATED accession with AE014075.1 UPDATED category_aro_description with Point mutations in the 23S rRNA subunit shown clinically to confer resistance to phenicol class antibiotics, including chloramphenicol and florfenicol, by disrupting antibiotic binding-site affinity. " 3320 UPDATE QnrS10 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_category "UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3321 UPDATE AAC(3)-IIe antibiotic inactivation; AAC(3); aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(3)-IIe is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. " 3323 UPDATE QnrS11 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_category "UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3324 UPDATE Erm(49) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; ARO_description "UPDATED ARO_description with Erm(49) is an rRNA methylase gene. " 3326 UPDATE QnrS15 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_category "UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3329 UPDATE Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin antibiotic target alteration; fluoroquinolone resistant parC; fluoroquinolone antibiotic; model_name "UPDATED model_name with Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin " 1775 UPDATE QnrS7 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrS7 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED accession with KF730651.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1774 UPDATE CTX-M-106 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with HQ913565.1 " 1777 UPDATE OXA-177 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-177 is a beta-lactamase found in A. baumannii. UPDATED accession with HM113563.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1776 UPDATE SHV-159 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121126.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1771 UPDATE TEM-19 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX042489.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1770 UPDATE TEM-127 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY368236.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1772 UPDATE aadA11 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa. UPDATED accession with AY758206.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1779 UPDATE CTX-M-12 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-12 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AF305837.1 " 1778 UPDATE OKP-A-5 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-5 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051143.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1352 UPDATE OXA-251 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN118546.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 321 UPDATE CTX-M-35 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-35 is a beta-lactamase found in Citrobacter koseri. UPDATED accession with AB176534.1 " 31 UPDATE CTX-M-155 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KM211508.1 " 327 UPDATE GES-17 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ874631.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 3502 UPDATE OXA-429 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1159 UPDATE TEM-129 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ746225.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1158 UPDATE SHV-22 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF117746.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1155 UPDATE ACT-9 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACT-9 is a beta-lactamase found in Pantoea agglomerans. UPDATED accession with HQ693810.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1154 UPDATE TEM-146 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTCCGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCACGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA UPDATED fmax with 861 UPDATED accession with DQ105529.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAZ14084.2 UPDATED sequence with MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLPDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1157 UPDATE vanG glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. UPDATED accession with DQ212986.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 1156 UPDATE Erm(31) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with AF079138.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 1151 UPDATE OXA-240 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX089628.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1150 UPDATE QnrVC5 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrVC5 is an integron-mediated quinolone resistance protein found in Vibrio fluvialis. UPDATED accession with JN408080.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1153 UPDATE KPC-3 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with KPC-3 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AF395881.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1152 UPDATE CTX-M-39 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-39 is a beta-lactamase found in Escherichia coli. UPDATED accession with AY954516.1 " 1488 UPDATE TEM-75 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY130284.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 30 UPDATE OXA-226 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-226 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with FJ617207.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1551 UPDATE OXA-78 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-78 is a beta-lactamase found in A. baumannii. UPDATED accession with AY862132.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1550 UPDATE smeR penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; aminoglycoside antibiotic; ARO_description; ARO_category "UPDATED ARO_description with smeR is the responder component of a two component signal transduction system that includes smeS. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1553 UPDATE tetS chlortetracycline; demeclocycline; oxytetracycline; tetracycline antibiotic; tetracycline; antibiotic target protection; minocycline; tetracycline-resistant ribosomal protection protein; doxycycline; model_sequences "UPDATED accession with L09756.1 " 1552 UPDATE MUS-1 carbapenem; antibiotic inactivation; MUS beta-lactamase; model_sequences; model_name "UPDATED accession with AF441286.1 UPDATED model_name with MUS-1 " 59 UPDATE OXA-256 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HE616889.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 58 UPDATE QnrB47 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB47 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED accession with JX440358.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1557 UPDATE SHV-187 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with LN515533.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1556 UPDATE VIM-13 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-13 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with DQ365886.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 55 UPDATE OXA-69 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-69 is a beta-lactamase found in A. baumannii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 54 UPDATE TEM-34 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC292503.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 57 UPDATE SHV-24 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB023477.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 56 UPDATE TEM-7 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 51 UPDATE AAC(3)-IIIc antibiotic inactivation; AAC(3); aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-IIIc is an aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with L06161.1 " 50 UPDATE SME-2 carbapenem; antibiotic inactivation; SME beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with SME-2 is a beta-lactamase found in Serratia marcescens. UPDATED accession with AF275256.1 " 53 UPDATE MOX-5 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; model_sequences; ARO_category "UPDATED accession with GQ152600.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 52 UPDATE OXY-2-2 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-2 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AF473577.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 537 UPDATE OXA-120 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-120 is a beta-lactamase found in A. baumannii. UPDATED accession with HE963768.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 536 UPDATE TEM-95 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ308558.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 535 UPDATE Morganella morganii gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutation in Morganella morganii resulting in fluoroquinolone resistance. UPDATED model_name with Morganella morganii gyrB conferring resistance to fluoroquinolones " 534 UPDATE vanVB glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanV; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanVB, is a vanV variant found in the vanB gene cluster. It is found in some but not all vanB operons in E. faecalis, suggesting the existence of varied gene compositions in vanB operons. UPDATED accession with AE016830.1 UPDATED model_name with vanV gene in vanB cluster UPDATED ARO_name with vanV gene in vanB cluster " 533 UPDATE CARB-16 penam; antibiotic inactivation; CARB beta-lactamase; model_sequences; ARO_category "UPDATED accession with HF953351.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 532 UPDATE CTX-M-47 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-47 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY847143.1 " 531 UPDATE SAT-3 streptothricin acetyltransferase (SAT); streptothricin; antibiotic inactivation; nucleoside antibiotic; model_sequences "UPDATED accession with Z48231.1 " 530 UPDATE VIM-11 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-11 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAGCGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG UPDATED fmax with 928 UPDATED accession with AY605049.2 UPDATED fmin with 127 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AAT36613.1 UPDATED sequence with MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGSEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1518 UPDATE EreA2 antibiotic inactivation; macrolide antibiotic; macrolide esterase; erythromycin; ARO_description; model_sequences "UPDATED ARO_description with EreA2 is an integron-encoded erythromycin esterase that hydrolyses the drug's lactone ring. EreA2 is found in Providencia stuartii. UPDATED accession with AF099140.1 " 539 UPDATE QnrB59 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB59 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JX259320.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1908 UPDATE OKP-A-6 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-6 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051144.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1558 UPDATE Bacillus subtilis mprF peptide antibiotic; antibiotic target alteration; defensin resistant mprF; defensin; model_sequences "UPDATED partial with 0 UPDATED sequence with TTGCTGATTAAAAAGAATGCTTTATCAATATTAAAAATCGTTTTTCCTATTGCTGTTTTGCTATTTGTTATTTATCAATCGAAAAAAGAACTGACAAATCTGTCATTCAAACGTACGCTCATGGTCATCAACGGACTGGAACGAACGGATTTATTCATGCTTGTGTTGATCGGCTTGCTGGCTGTTGCGGCTATGTCGCTGTATGATTACGTCCTGAAGTACTCACTGCGCCTATCGATCACAAACGGAAAAGTTTTCAGGGTTTCCTGGATCGCCAATTCATTTAATAATGTGTTGGGATTCGGCGGTTTAGCCGGAGTCGGGTTAAGAATGATGTTCTATAAGGAGCATACGAAAGACCATAAGGCACTCGTGAAAGGAATCGCCTGGCTCACATCATCTATGCTGCTCGGATTATCTGTTTTCAGCATTTTCGTTGCTGCGAGAGTGCTGCCAGTTGATGAAGTGATTCATGAGAAGCCTTGGCTGTGGGCGGTCGTTATCGGTTTTGCACTGATATTGCCGTTATCTTTAGCGGTGTCCAAAATAAAAGACCGCAAAGCTGGGGACGAAGAGAATGCGGATAAAGTGAAAAATCCGATTTTCGCATATATTGGAGCTTCAGTTGTTGAATGGCTCATGGCCGGGACCGTCATCTATTTTGCTTTGTTCGCTATGGGCATTCATGCAGATATCAGGTATGTGTTCGGGGTGTTCGTCATTGCGGCGATCGGAGGAATGATCAGCCTCGTGCCGGGCGGCTTCGGCTCGTTTGACCTTTTATTTTTGCTGGGGATGGAGCAGCTTGGCTATCATCAAGAGGCCATCGTTACTTCTATTGTGTTGTACAGGCTCGCCTACTCATTTATCCCATTTATCTTGGGACTGTTCTTTGCCGCCGGCGACCTGACGGAAAATACAATGAAGCGGCTCGAAACGAACCCGCGCATCGCACCGGCAATTGAGACGACAAACGTTCTGCTTGTTGTTCAGCGTGCGGTATTAGTGAGAATTTTGCAAGGCTCGCTTTCCCTTATTGTGTTCGTAGCAGGTCTGATTGTCTTGGCCTCAGTTTCCTTGCCGATTGACAGGCTGACGGTTATACCGCACATTCCGCGCCCGGCGCTTTTGCTGTTCAACGGCCTGTCCTTAAGCTCAGCGCTCATTCTGCTCATTTTGCCGATCGAGCTTTATAAACGGACAAAACGTTCCTACACGATGGCCATTACAGCGCTTGTCGGCGGCTTTGTGTTCAGCTTTTTAAAAGGGCTTAACATCAGCGCGATATTCGTACTGCCGATGATTATCGTATTGCTTGTGCTATTGAAAAAACAATTTGTCCGCGAACAGGCATCCTATACACTGGGACAATTGATATTCGCTGTGGCGCTGTTTACTGTGGCGCTCTTTAACTACAATCTGATCGCGGGCTTTATTTGGGACCGGATGAAGAAGGTGCTGCGTCACGAATATTTCGTCCACAGCACCTCGCATATTACACATGCAACCATCATGGCGATCATCATTGTGCCGCTGTTCTTCTTGATATTTACAGTGGTCTATCATAAGAGAACGAAACCGATCGGAGAGAAAGCTGACCCTGAGCGTCTTGCTGCGTTTCTCAATGAAAAAGGCGGCAACGCGCTGAGCCATCTTGGTTTTCTTGGAGATAAGCGGTTTTATTTTTCTAGCGATGGAAATGCACTGCTTCTGTTTGGGAAAATCGCCAGAAGGCTGGTCGTGCTCGGCGATCCATCTGGCCAAAGAGAATCATTCCCGCTCGTGCTGGAAGAATTTCTGAACGAAGCGCATCAGAAGGGATTCAGTGTTTTGTTCTATCAAATTGAACGAGAGGACATGGCGCTGTATCACGATTTTGGCTACAACTTCTTTAAATTGGGTGAGGAAGCATATGTAGATTTAAATACATTTACCTTGACTGGGAAGAAAAAAGCCGGCCTTCGGGCAATCAATAACCGCTTTGAGCGGGAGGAGTATACTTTCCATGTGGATCATCCCCCATTTTCTGATGCGTTTTTGGAGGAGCTGAAGCAAATCTCAGACGAATGGCTCGGCTCGAAAAAAGAGAAGGGATTCTCGCTCGGATTTTTTGATCCTTCCTATTTACAGAAAGCGCCGATCGCCTATATGAAAAATGCAGAAGGAGAGATCGTTGCATTCGCAAATGTCATGCCGATGTACCAGGAAGGAGAGATATCGGTCGATCTGATGCGCTATCGCGGCGACGCTCCAAATGGCATTATGGACGCATTGTTTATCCGTATGTTTTTATGGGCAAAGGAAGAGGGCTGTACGTCATTTAATATGGGGATGGCACCCTTGGCCAATGTCGGCACTGCCTTTACATCCTTCTGGTCCGAAAGGTTTGCCGCTGTCATTTTTAATAATGTCAGATACATGTACAGTTTCAGCGGCCTAAGAGCCTTTAAAGAAAAATATAAACCGGAGTGGCGAGGGAAATACTTAGCGTATCGGAAAAACAGATCTCTTTCTGTCACCATGTTCCTCGTTACACGTCTGATTGGCAAAAGCAAAAAAGACTCCGTCTAA UPDATED fmax with 919348 UPDATED accession with AL009126.3 UPDATED fmin with 916777 UPDATED strand with + UPDATED NCBI_taxonomy_name with Bacillus subtilis subsp. subtilis str. 168 UPDATED NCBI_taxonomy_id with 224308 UPDATED NCBI_taxonomy_cvterm_id with 39579 UPDATED accession with CAX52582.1 UPDATED sequence with MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVINGLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFGGLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEKPWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTVIYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAIVTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAVLVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLILPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAIIIVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDGNALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYHDFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEELKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEISVDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAAVIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV " 1909 UPDATE AAC(6')-Iak AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(6')-Iak is a 6'-N-aminoglycoside acetyltransferase-encoding gene isolated from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia. " 3296 UPDATE erm(45) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; model_sequences; model_name "UPDATED NCBI_taxonomy_name with Mammaliicoccus fleurettii UPDATED model_name with erm(45) " 4690 UPDATE IMP-63 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1905 UPDATE ACT-21 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KF526118.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 304 UPDATE IND-11 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-11 is a beta-lactamase found in Escherichia coli. UPDATED accession with HM245379.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 1902 UPDATE OXA-246 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-246 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with KF711993.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3455 UPDATE OXA-292 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3291 UPDATE Erm(48) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; model_sequences "UPDATED accession with LT223129.1 " 429 UPDATE mdsA penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; penem; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; monobactam; phenicol antibiotic; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 428 UPDATE OXY-2-7 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-7 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with Z49084.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1900 UPDATE ACT-13 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with HE819402.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1399 UPDATE OXA-315 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-315 is a beta-lactamase found in A. baumannii. UPDATED accession with KF057032.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1398 UPDATE OXA-108 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-108 is a beta-lactamase found in A. baumannii. UPDATED accession with EF650034.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 421 UPDATE TEM-2 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with X54606.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 420 UPDATE CTX-M-1 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-1 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with X92506.1 " 1395 UPDATE Neisseria gonorrhoeae porin PIB (por) penam; reduced permeability to antibiotic; penem; cephamycin; carbapenem; cephalosporin; penicillin; General Bacterial Porin with reduced permeability to beta-lactams; tetracycline antibiotic; monobactam; tetracycline; model_sequences; model_name; ARO_category "UPDATED accession with U75641.1 UPDATED model_name with Neisseria gonorrhoeae porin PIB (por) UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 422 UPDATE FOX-10 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX049131.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 425 UPDATE TEM-182 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with TEM-182 is a beta-lactamase found in clinical isolates of H. parainfluenzae. UPDATED accession with HQ317449.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 424 UPDATE SHV-36 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF467947.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1391 UPDATE CTX-M-92 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-92 is a beta-lactamase found in Escherichia coli. UPDATED accession with GU127598.1 " 1390 UPDATE arlR antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3812 UPDATE ROB-6 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3813 UPDATE ROB-7 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3810 UPDATE ROB-4 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3811 UPDATE ROB-5 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3816 UPDATE ROB-10 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3814 UPDATE ROB-9 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3815 UPDATE ROB-8 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3818 UPDATE Thermus thermophilus 23s rRNA conferring resistance to pleuromutilin antibiotics 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics; antibiotic target alteration; pleuromutilin antibiotic; ARO_category "UPDATED category_aro_description with Point mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics. " 850 UPDATE OXA-26 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-26 is a beta-lactamase found in A. baumannii. UPDATED accession with AF201827.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 302 UPDATE TEM-207 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC818234.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 851 UPDATE Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide antibiotic target alteration; Pyrazinamide resistant pncA; pyrazinamide; model_sequences; ARO_category "UPDATED accession with AL123456.1 UPDATED category_aro_name with Pyrazinamide resistant pncA UPDATED category_aro_description with pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide to pyrazinoic acid. Mutations arise within the pncA gene that caused the loss of pyrazinamidase activity is the major mechanism of antibiotic resistance. " 307 UPDATE CTX-M-101 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with HQ398214.1 " 1422 UPDATE ACC-3 penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACC-3 is a beta-lactamase found in Hafnia alvei. UPDATED accession with AF180958.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1443 UPDATE CARB-7 penam; antibiotic inactivation; CARB beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF409092.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1426 UPDATE IMP-7 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-7 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AF318077.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1425 UPDATE RbpA rifampin; rifapentine; RbpA bacterial RNA polymerase-binding protein; antibiotic target protection; rifabutin; rifaximin; rifamycin antibiotic; model_sequences "UPDATED accession with HQ203032.1 " 4743 UPDATE LEN-27 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4741 UPDATE KPC-82 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4740 UPDATE KPC-81 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4745 UPDATE LEN-31 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4744 UPDATE LEN-28 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1424 UPDATE OXY-2-4 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-4 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with Y17714.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3475 UPDATE OXA-341 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 722 UPDATE vanRA vanR; glycopeptide resistance gene cluster; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; vancomycin; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRA, is a vanR variant found in the vanA gene cluster. UPDATED accession with M97297.1 UPDATED model_name with vanR gene in vanA cluster UPDATED ARO_name with vanR gene in vanA cluster " 2183 UPDATE glycopeptide resistance gene cluster VanB glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with This inducible cluster confers resistance to vancomycin but organisms remain sensitive to teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Sensitivity to teicoplanin is due to lack of binding to the sensor kinase VanS. The vanB gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSYWHBX. " 2182 UPDATE glycopeptide resistance gene cluster VanD glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Homologous to vanA, contains a D-Ala-D-Lac ligase. This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin. Gene orientation: vanRSYHDX. " 2181 UPDATE glycopeptide resistance gene cluster VanF glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Homologous to vanA, contains a D-Ala-D-Lac ligase. The vanF gene cluster is inducible and confers high resistance to vancomycin in Paenibacillus popilliae. vanF organisms remain susceptible to teicoplanin. Gene orientation: RSYZHFX. " 2180 UPDATE glycopeptide resistance gene cluster VanL glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes. Gene orientation: vanL(XY)TmTrRS. " 2186 UPDATE glycopeptide resistance gene cluster VanG glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes. Gene orientation: vanRSYWGYT. " 229 UPDATE vanTmL glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanT; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanTmL, is a vanT variant found in the vanL gene cluster. vanTmL codes for the membrane-binding domain of vanTL. UPDATED accession with EU250284.1 UPDATED model_name with vanTm gene in vanL cluster UPDATED ARO_name with vanTm gene in vanL cluster " 228 UPDATE sdiA penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 227 UPDATE OKP-B-3 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-3 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051152.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 226 UPDATE OXA-113 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-113 is a beta-lactamase found in A. baumannii. UPDATED accession with EF653400.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 224 UPDATE MIR-2 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY227752.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 223 UPDATE GES-3 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-3 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AB113580.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 222 UPDATE JOHN-1 carbapenem; penam; cephalosporin; antibiotic inactivation; JOHN beta-lactamase; model_sequences; model_name; ARO_category "UPDATED accession with AY028464.1 UPDATED model_name with JOHN-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 221 UPDATE CMY-100 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KF526113.1 " 220 UPDATE TEM-92 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF143804.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2213 UPDATE opmE kitasamycin; imipenem; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; antibiotic efflux; trimethoprim; macrolide antibiotic; disinfecting agents and antiseptics; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; acriflavine; tetracycline antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 2212 UPDATE mexQ kitasamycin; imipenem; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; antibiotic efflux; trimethoprim; macrolide antibiotic; disinfecting agents and antiseptics; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; acriflavine; tetracycline antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 2211 UPDATE mexP kitasamycin; imipenem; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; antibiotic efflux; trimethoprim; macrolide antibiotic; disinfecting agents and antiseptics; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; acriflavine; tetracycline antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; erythromycin; ARO_description; ARO_category "UPDATED ARO_description with MexP is the membrane fusion protein of the MexPQ-OpmE multidrug efflux complex. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 2215 UPDATE Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone resistant parC; fluoroquinolone antibiotic; model_name "UPDATED model_name with Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones " 2219 UPDATE MexL antibiotic efflux; triclosan; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; disinfecting agents and antiseptics; tetracycline; erythromycin; ARO_category; model_name "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED model_name with MexL " 4713 UPDATE IND-16 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_category "UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 1089 UPDATE CMY-14 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-14 is a beta-lactamase found in Proteus mirabilis. UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGATAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA UPDATED fmax with 1146 UPDATED accession with AJ555825.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Proteus mirabilis UPDATED NCBI_taxonomy_id with 584 UPDATED NCBI_taxonomy_cvterm_id with 36771 UPDATED accession with CAD88479.1 UPDATED sequence with MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEINPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ " 2786 UPDATE Burkholderia pseudomallei Omp38 penam; reduced permeability to antibiotic; imipenem; penem; benzylpenicillin; cephalosporin; carbapenem; ceftazidime; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; cefoxitin; model_sequences; ARO_category "UPDATED accession with AY312416.1 UPDATED accession with AAP82271.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 151 UPDATE OKP-A-15 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-15 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with FJ755841.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 150 UPDATE catB3 antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 155 UPDATE TEM-195 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN935137.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 154 UPDATE mgrA penam; peptide antibiotic; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; sparfloxacin; norfloxacin; disinfecting agents and antiseptics; moxifloxacin; daptomycin; cefotaxime; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; acriflavine; ciprofloxacin; tetracycline antibiotic; moenomycin A1; fluoroquinolone antibiotic; methicillin; tetracycline; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 157 UPDATE dfrA21 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA21 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. UPDATED accession with AM932669.1 " 156 UPDATE AAC(6')-Iaf AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iaf is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. UPDATED accession with AB462903.1 " 159 UPDATE vgaALC dalfopristin; pleuromutilin; virginiamycin M1; pleuromutilin antibiotic; madumycin II; griseoviridin; ABC-F ATP-binding cassette ribosomal protection protein; macrolide antibiotic; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; model_sequences; ARO_category "UPDATED accession with DQ823382.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 158 UPDATE myrA antibiotic target alteration; non-erm 23S ribosomal RNA methyltransferase (G748); macrolide antibiotic; lincosamide antibiotic; model_sequences; ARO_category "UPDATED accession with D16099.1 UPDATED category_aro_description with Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides. " 1293 UPDATE OXA-197 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ425495.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1088 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to daptomycin peptide antibiotic; daptomycin resistant beta-subunit of RNA polymerase (rpoB); antibiotic target alteration; daptomycin; rifamycin antibiotic; ARO_description "UPDATED ARO_description with Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to daptomycin. " 2436 UPDATE D-Ala-D-Ala ligase glycopeptide antibiotic; antibiotic target alteration; Van ligase; ARO_category "UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 2434 UPDATE Klebsiella pneumoniae OmpK36 penam; reduced permeability to antibiotic; penem; carbapenem; cephalosporin; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; resistance by absence; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). " 1161 UPDATE lsaB pleuromutilin; pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; clindamycin; phenicol antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with LsaB is an ABC-F subfamily protein expressed in Mammaliicoccus sciuri. It confers resistance to clindamycin. UPDATED NCBI_taxonomy_name with Mammaliicoccus sciuri " 1359 UPDATE OXA-233 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ657570.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1162 UPDATE aadA15 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA15 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. UPDATED accession with DQ393783.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1428 UPDATE cphA2 carbapenem; CphA beta-lactamase; antibiotic inactivation; ARO_description; model_sequences "UPDATED ARO_description with CphA2 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. UPDATED accession with U60294.1 " 2724 UPDATE MuxABC-OpmB kitasamycin; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; aztreonam; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; monobactam; tetracycline; erythromycin; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 2720 UPDATE MuxC kitasamycin; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; aztreonam; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; monobactam; tetracycline; erythromycin; model_sequences "UPDATED accession with AAG05914.1 " 2729 UPDATE MexJK-OprM antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; tetracycline; erythromycin; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 1163 UPDATE CMY-94 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JX514368.1 " 5049 UPDATE OXA-740 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5048 UPDATE OXA-739 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5047 UPDATE OXA-738 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5046 UPDATE OXA-736 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5045 UPDATE OXA-735 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5044 UPDATE OXA-734 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5043 UPDATE OXA-733 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5042 UPDATE OXA-732 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5041 UPDATE OXA-731 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5040 UPDATE OXA-730 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1807 UPDATE OXA-70 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-70 is a beta-lactamase found in A. baumannii. UPDATED accession with AY750912.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1806 UPDATE OXA-14 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1805 UPDATE TEM-131 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY436361.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1804 UPDATE OXA-107 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-107 is a beta-lactamase found in A. baumannii. UPDATED accession with EF650033.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1803 UPDATE QnrVC3 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrVC3 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. UPDATED accession with HM015626.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1802 UPDATE OXA-168 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM488989.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1801 UPDATE AAC(6')-Ib11 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ib11 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. UPDATED accession with AY136758.1 " 1800 UPDATE SHV-120 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JF812965.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1809 UPDATE QnrB5 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB5 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. UPDATED accession with DQ303919.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4996 UPDATE OXA-684 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4997 UPDATE OXA-685 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4994 UPDATE OXA-682 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4995 UPDATE OXA-683 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4992 UPDATE OXA-679 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4993 UPDATE OXA-680 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4990 UPDATE OXA-677 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4991 UPDATE OXA-678 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 126 UPDATE TEM-183 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ529916.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4998 UPDATE OXA-686 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4999 UPDATE OXA-687 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1532 UPDATE OXA-249 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-249 is a beta-lactamase found in A. baumannii. UPDATED accession with HE963770.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1547 UPDATE vanRC glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRC, is a vanR variant found in the vanC gene cluster. UPDATED accession with AF162694.1 UPDATED model_name with vanR gene in vanC cluster UPDATED ARO_name with vanR gene in vanC cluster " 1183 UPDATE tetQ chlortetracycline; demeclocycline; oxytetracycline; tetracycline antibiotic; tetracycline; antibiotic target protection; minocycline; tetracycline-resistant ribosomal protection protein; doxycycline; model_sequences "UPDATED accession with Z21523.1 " 3258 UPDATE dfrA27 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with A dihydrofolate reductase and trimethoprim resistance gene from non-O1, non-O139 Vibrio cholerae. " 1524 UPDATE Lactobacillus reuteri cat-TC antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; ARO_name; model_sequences; model_name; ARO_category "UPDATED ARO_description with cat-TC is a plasmid-encoded variant of the cat gene found in Limosilactobacillus reuteri. UPDATED ARO_name with Limosilactobacillus reuteri cat-TC UPDATED accession with U75299.1 UPDATED NCBI_taxonomy_name with Limosilactobacillus reuteri UPDATED model_name with Limosilactobacillus reuteri cat-TC UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1948 UPDATE TEM-167 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ360884.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1949 UPDATE cphA6 carbapenem; CphA beta-lactamase; antibiotic inactivation; model_sequences "UPDATED accession with AY227052.1 " 1257 UPDATE QnrB68 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB68 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. UPDATED accession with KC580657.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1942 UPDATE BJP-1 carbapenem; antibiotic inactivation; BJP beta-lactamase; model_name "UPDATED model_name with BJP-1 " 1943 UPDATE Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid isoniazid; antibiotic target alteration; antibiotic resistant kasA; ARO_description; model_sequences "UPDATED ARO_description with Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid, resulting in resistance. UPDATED accession with AL123456.1 " 1940 UPDATE QnrB30 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB30 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. UPDATED accession with HM439650.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1941 UPDATE SHV-98 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM941844.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1946 UPDATE CTX-M-10 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-10 is a beta-lactamase found in Escherichia coli. UPDATED accession with AY598759.1 " 3256 UPDATE dfrA9 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with A dihydrofolate reductase and trimethoprim resistance gene identified from porcine isolates of Esherichia coli. " 1945 UPDATE SHV-50 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY288915.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 818 UPDATE SHV-141 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ388884.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 819 UPDATE CTX-M-68 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-68 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with EU177100.1 " 1255 UPDATE OXA-119 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-119 is a beta-lactamase found in Enterobacteriaceae. UPDATED accession with AY139598.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 810 UPDATE mecC penam; methicillin resistant PBP2; antibiotic target replacement; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 811 UPDATE TEM-26 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 812 UPDATE CMY-10 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-10 is a beta-lactamase found in Klebsiella aerogenes. UPDATED accession with AF357597.1 " 813 UPDATE OXA-216 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with FR865168.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 814 UPDATE TEM-113 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY589494.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 815 UPDATE GOB-1 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; model_name; ARO_category "UPDATED accession with AF090141.1 UPDATED model_name with GOB-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 816 UPDATE OXA-3 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-3 is a beta-lactamase found in P. aeruginosa. UPDATED accession with L07945.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 817 UPDATE CTX-M-158 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KM211691.1 " 2859 UPDATE PDC-80 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 1991 UPDATE otrC tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; tetracycline; antibiotic efflux; ARO_description; model_sequences "UPDATED ARO_description with otrC is a tetracycline resistance efflux pump found in Streptomyces rimosus. UPDATED accession with AY509111.1 " 1250 UPDATE CTX-M-96 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with AJ704396.1 " 1990 UPDATE CMY-82 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KJ207203.1 " 2851 UPDATE Escherichia coli gyrA with mutation conferring resistance to triclosan antibiotic target alteration; triclosan; disinfecting agents and antiseptics; triclosan resistant gyrA; ARO_category "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2850 UPDATE Salmonella enterica gyrA with mutation conferring resistance to triclosan antibiotic target alteration; triclosan; disinfecting agents and antiseptics; triclosan resistant gyrA; ARO_category "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2853 UPDATE PDC-74 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 1251 UPDATE CTX-M-157 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KM211510.1 " 2855 UPDATE PDC-76 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 1621 UPDATE SHV-45 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF547625.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2857 UPDATE PDC-78 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2856 UPDATE PDC-77 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 1494 UPDATE LAT-1 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with LAT-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with X78117.1 " 1498 UPDATE cphA8 carbapenem; CphA beta-lactamase; antibiotic inactivation; model_sequences "UPDATED accession with AY261375.1 " 1499 UPDATE VEB-6 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with VEB-6 is a beta-lactamase found in Proteus mirabilis. UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 3338 UPDATE AAC(6')-Iag antibiotic inactivation; kanamycin A; aminoglycoside antibiotic; AAC(6'); isepamicin; sisomicin; arbekacin; amikacin; dibekacin; tobramycin; ARO_description "UPDATED ARO_description with AAC(6')-Iag is an aminoglycoside acetyltransferase encoded by integrons in Pseudomonas aeruginosa. " 423 UPDATE DHA-16 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087852.1 " 1626 UPDATE vgaE dalfopristin; pleuromutilin; virginiamycin M1; pleuromutilin antibiotic; madumycin II; griseoviridin; ABC-F ATP-binding cassette ribosomal protection protein; macrolide antibiotic; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; model_sequences; ARO_category "UPDATED accession with FR772051.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 1700 UPDATE ACT-28 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KJ207206.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1701 UPDATE Erm(39) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with AY487229.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 1702 UPDATE MIR-1 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with MIR-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTTCGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA UPDATED fmax with 2073 UPDATED accession with M37839.2 UPDATED fmin with 927 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAD22636.1 UPDATED sequence with MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHFAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 1704 UPDATE CMY-57 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-57 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with HQ285243.1 " 1705 UPDATE SHV-111 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB372881.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1706 UPDATE OXA-142 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-142 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with EU358785.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1707 UPDATE QnrB4 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB4 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGACTCTGGCGTTAGTTGGCGAAAAAATTGACAGAAACAGGTTCACCGGTGAAAAAGTTGAAAATAGCACATTTTTCAACTGTGATTTTTCGGGTGCCGACCTTAGCGGCACTGAATTTATTGGCTGCCAGTTTTATGATCGAGAAAGTCAGAAAGGATGTAATTTTAGTCGCGCTAACCTGAAAGATGCCATTTTCAAAAGTTGTGATCTCTCCATGGCTGATTTCAGGAATATCAATGCGCTGGGAATCGAAATTCGCCACTGCCGGGCACAAGGGTCAGATTTTCGCGGCGCAAGTTTTATGAATATGATCACCACCCGCACCTGGTTTTGTAGCGCCTATATCACCAATACCAACTTAAGCTACGCCAACTTTTCAAAAGTCGTACTGGAAAAGTGCGAGCTGTGGGAAAACCGCTGGATGGGTACTCAGGTGCTGGGCGCAACGTTCAGTGGATCAGACCTCTCTGGCGGCGAGTTTTCATCCTTCGACTGGCGAGCAGCAAACGTTACGCACTGTGATTTGACCAATTCGGAACTGGGCGATTTAGATATCCGCGGGGTTGATTTGCAAGGCGTCAAACTGGACAGCTACCAGGCATCGTTGCTCCTGGAACGTCTTGGTATCGCTGTCATGGGTTAA UPDATED fmax with 648 UPDATED accession with DQ303921.2 UPDATED fmin with 3 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ABC17630.3 UPDATED sequence with MTLALVGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRANLKDAIFKSCDLSMADFRNINALGIEIRHCRAQGSDFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGTQVLGATFSGSDLSGGEFSSFDWRAANVTHCDLTNSELGDLDIRGVDLQGVKLDSYQASLLLERLGIAVMG UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1708 UPDATE tet36 chlortetracycline; demeclocycline; oxytetracycline; tetracycline antibiotic; tetracycline; antibiotic target protection; minocycline; tetracycline-resistant ribosomal protection protein; doxycycline; model_sequences "UPDATED accession with AJ514254.1 " 1393 UPDATE THIN-B carbapenem; penam; cephalosporin; antibiotic inactivation; THIN-B beta-lactamase; model_sequences; model_name; ARO_category "UPDATED accession with AJ250876.1 UPDATED model_name with THIN-B UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1168 UPDATE NDM-9 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAAAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA UPDATED fmax with 1192 UPDATED accession with KC999080.2 UPDATED fmin with 379 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae subsp. pneumoniae UPDATED NCBI_taxonomy_id with 72407 UPDATED NCBI_taxonomy_cvterm_id with 39097 UPDATED accession with AGU91756.1 UPDATED sequence with MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQKGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1996 UPDATE vanXM glycopeptide antibiotic; glycopeptide resistance gene cluster; vanX; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXM, is a vanX variant found in the vanM gene cluster. UPDATED accession with FJ349556.1 UPDATED model_name with vanX gene in vanM cluster UPDATED ARO_name with vanX gene in vanM cluster " 2097 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; paromomycin; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to paromomycin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin " 1392 UPDATE aadA22 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA22 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in S. enterica and E. coli. UPDATED accession with AM261837.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 2333 UPDATE LEN-26 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2096 UPDATE Escherichia coli 16S rRNA (rrsC) mutation conferring resistance to kasugamicin antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kasugamycin; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' minor, 3' major, and central domains in the rrsC 16S rRNA gene of Escherichia coli can confer resistance to kasugamicin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsC) mutation conferring resistance to kasugamicin " 427 UPDATE OCH-7 penam; antibiotic inactivation; penem; cephalosporin; cephamycin; monobactam; OCH beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OCH-7 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. UPDATED accession with AJ295345.1 UPDATED NCBI_taxonomy_name with Brucella anthropi UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. " 2091 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to gentamicin C antibiotic target alteration; gentamicin C; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutations in the 16S rRNA of Mycobacteroides chelonae can confer resistance to gentamicin C. " 426 UPDATE aadK antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); model_sequences; ARO_category "UPDATED accession with AL009126.1 UPDATED category_aro_description with Nucelotidylylation of streptomycin at the hydroxyl group at position 6. " 5188 UPDATE OXA-891 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2090 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to kanamycin kanamycin A; antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to kanamycin. " 1128 UPDATE OXA-23 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-23 is a beta-lactamase found in A. baumannii. UPDATED accession with AY795964.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1129 UPDATE CMY-19 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-19 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AB194410.1 " 5189 UPDATE OXA-892 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2093 UPDATE Chlamydophila psittaci 16S rRNA mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutation in the 16S rRNA helix 34 region of Chlamydophila psittaci can confer resistance against spectinomycin. " 1120 UPDATE IMI-7 carbapenem; antibiotic inactivation; IMI beta-lactamase; model_sequences "UPDATED accession with KM103296.1 " 1121 UPDATE APH(3')-VIa antibiotic inactivation; aminoglycoside antibiotic; isepamicin; paromomycin; kanamycin A; APH(3'); gentamicin B; amikacin; ribostamycin; G418; neomycin; butirosin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-VIa is a plasmid-encoded aminoglycoside phosphotransferase in A. baumannii. UPDATED accession with X07753.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 1122 UPDATE OXA-180 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM570036.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1123 UPDATE FOX-8 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with FOX-8 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with HM565917.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 1124 UPDATE TEM-186 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN227084.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1125 UPDATE OKP-B-11 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-11 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051161.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1126 UPDATE OXA-184 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ396378.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1127 UPDATE CTX-M-64 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-64 is a beta-lactamase found in Shigella sonnei. UPDATED partial with 0 UPDATED sequence with ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCAAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATGACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA UPDATED fmax with 1101 UPDATED accession with AB284167.2 UPDATED fmin with 225 UPDATED strand with + UPDATED NCBI_taxonomy_name with Shigella sonnei UPDATED NCBI_taxonomy_id with 624 UPDATED NCBI_taxonomy_cvterm_id with 36790 UPDATED accession with BAF63422.1 UPDATED sequence with MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL " 3654 UPDATE Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin antibiotic target alteration; Zoliflodacin; Zoliflodacin resistant gyrB; ARO_description; model_sequences; model_param "UPDATED ARO_description with Point mutation in Neisseria gonorrhoea gyrase B decreases affinity to zoliflodacin antibiotic. UPDATED partial with 0 UPDATED sequence with ATGACTGAACAAAAACACGAAGAATACGGCGCCGACAGCATCCAGGTGCTCGAAGGCTTGGAAGCGGTACGCAAACGCCCCGGCATGTACATCGGCGACACGCAGGACGGCAGCGGGCTGCACCATATGGTGTTTGAAGTATTGGACAACGCCATCGACGAAGCACTCGCCGGACATTGCGACAAAATCACGGTAACGATACACGCCGACCATTCCGTCAGCGTCGCCGACAACGGGCGCGGTATGCCCACCGGCATCCACCCGAAAGAAGGGCGTTCCGCCGCCGAAGTCATCATGACCGTCTTGCACGCGGGCGGCAAATTCGACAACAACAGCTACAAAATCTCCGGCGGCCTGCACGGCGTGGGCGTATCCGTCGTCAACGCGCTGTCCGACTGGGTAACGCTGACCATCTACCGCGACGGCAAAGAACACTTCGTCCGCTTCGTACGCGGCGAAACCGAAGAGCCGCTGAAAATTGTCGGCGATTCCGACAAAAAAGGCACGACCGTGCGCTTCCTCGCCGGCACGGAAACCTTCGGCAATATCGAATACAGCTTCGACATCCTCGCCAAACGTATTCGCGAACTTTCGTTCCTAAACAACGGCGTGGACATCGAATTGACCGACGAGCGCGACGGCAAGCACGAAAGCTTCGCCCTTTCCGGCGGCGTGGCGGGCTTCGTGCAATACATGAACCGCAAAAAAACGCCCTTGCACGAAAAAATCTTCTATGCGTTCGGCGAGAAAGACGGCATGAGCGTCGAATGCGCAATGCAATGGAACGACAGCTATCAGGAAAGCGTGCAGTGCTTCACCAACAACATCCCTCAGCGCGACGGCGGTACGCACCTGACCGCGCTGCGCCAAGTGATGACGCGCACCATCAACAGCTACATCGAAGCTAACGAAGTCGCCAAAAAAGCCAAAGTGGAAACCGCCGGCGACGATATGCGCGAAGGTTTGACCTGCGTGTTGTCCGTCAAACTGCCCGACCCCAAATTCTCATCCCAAACCAAAGACAAACTGGTTTCCGGCGAAATCGGCCCCGTTGTCAACGAAGTCATCAACCAAGCACTAACCGACTTCCTCGAAGAAAATCCGAACGAAGCCAAAATCATCACCGGCAAAATCGTCGATGCCGCCCGCGCACGCGAAGCCGCCCGCAAAGCCCGCGAAATCCCCCGCCGCAAAGGCGTGATGGACGGCTTGGGACTGCCCGGCAAACTCGCCGACTGCCAAGAAAAAGACCCTGCCCTGTCTGAACTCTACCTCGTCGAGGGCGACTCCGCAGGCGGTTCCGCCATGCAGGGCCGCGACCGCAAATTCCAAGCGATTTTGCCGCTCAAAGGTAAAATTTTGAACGTCGAAAAAGCACGTTTTGAAAAAATGCTCGCCAGCCAAGAGGTCGCCACCCTGATTACCGCGCTGGGTGCAGGCATCGGCAAAGAAGAGTTCAACCCTGAAAAACTACGCTACCACCGCATCATCATCATGACCGATGCCGACGTGGACGGTGCGCACATCCGCACCCTGCTCCTGACCTTCTTCTACCGCCAAATGCCCGAACTGGTCGAGCGCGGCTACATTTACATCGCCCAGCCGCCGCTCTACAAAGCCAAATACGGCAAGCAGGAGCGTTACCTCAAAGACGAACTGGAAAAAGACCAATGGCTGCTCGGCCTTGCCTTGGAAAAAGCCAAAATCGTTTCAGACGGCCGCACCATCGAAGGCGCAGAACTTGCCGACACCGCCAAACAATTCTTGTTGGCGAAAACCGTCATCGAACAGGAAAGCCGCTTCGTGGACGAACTCGTCCTGCGTGCCATGCTGCACGCGTCGCCCATTGATTTGACGTCGTCTGAAAACGCCGATAAAGCCGTTGCCGAACTTTCCGGTTTGCTTGACGAAAAAGAAGCCGCCCTCGAACGCATCGAAGGTCATGAAGGACACCAGTTCATCAAAATCACGCGCAAGCTGCACGGCAACGTCATGGTCAGCTACATCGAACCCAAGTTCCTCAACAGCAAAGCCTACCAAACCCTCACCCAAACCGCCGCCGCGCTCAAAGGCTTGGTCGGCGAGGGCGCCAAGCTCTACAAAGGCGAGAACGAGTACGACGCGGACAGCTTTGAAACCGCTTTGGACATCTTGATGAGCGTTGCCCAAAAAGGTATGTCCATCCAACGATACAAAGGTTTGGGCGAGATGAACCCCGAGCAGCTTTGGGAAACCACGATGGATCCCACCGTGCGCCGCCTGTTGAAAGTGCGCATCGAAGATGCCATTGCCGCCGACGAAGTGTTCGTTACCCTGATGGGCGACGAGGTCGAACCGCGCCGCGCCTTTATCGAAAACAATGCGCTGATTGCGCAAAATATCGACGCATAA UPDATED fmax with 48284 UPDATED accession with CQOZ01000008.1 UPDATED fmin with 45893 UPDATED strand with - UPDATED NCBI_taxonomy_name with Neisseria gonorrhoeae UPDATED NCBI_taxonomy_id with 485 UPDATED NCBI_taxonomy_cvterm_id with 36806 UPDATED accession with CNT74515.1 UPDATED sequence with MTEQKHEEYGADSIQVLEGLEAVRKRPGMYIGDTQDGSGLHHMVFEVLDNAIDEALAGHCDKITVTIHADHSVSVADNGRGMPTGIHPKEGRSAAEVIMTVLHAGGKFDNNSYKISGGLHGVGVSVVNALSDWVTLTIYRDGKEHFVRFVRGETEEPLKIVGDSDKKGTTVRFLAGTETFGNIEYSFDILAKRIRELSFLNNGVDIELTDERDGKHESFALSGGVAGFVQYMNRKKTPLHEKIFYAFGEKDGMSVECAMQWNDSYQESVQCFTNNIPQRDGGTHLTALRQVMTRTINSYIEANEVAKKAKVETAGDDMREGLTCVLSVKLPDPKFSSQTKDKLVSGEIGPVVNEVINQALTDFLEENPNEAKIITGKIVDAARAREAARKAREIPRRKGVMDGLGLPGKLADCQEKDPALSELYLVEGDSAGGSAMQGRDRKFQAILPLKGKILNVEKARFEKMLASQEVATLITALGAGIGKEEFNPEKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPELVERGYIYIAQPPLYKAKYGKQERYLKDELEKDQWLLGLALEKAKIVSDGRTIEGAELADTAKQFLLAKTVIEQESRFVDELVLRAMLHASPIDLTSSENADKAVAELSGLLDEKEAALERIEGHEGHQFIKITRKLHGNVMVSYIEPKFLNSKAYQTLTQTAAALKGLVGEGAKLYKGENEYDADSFETALDILMSVAQKGMSIQRYKGLGEMNPEQLWETTMDPTVRRLLKVRIEDAIAADEVFVTLMGDEVEPRRAFIENNALIAQNIDA UPDATED 12583 with K450T UPDATED 12582 with K450N UPDATED 12584 with D429N UPDATED 12583 with K450T UPDATED 12582 with K450N UPDATED 12584 with D429N " 305 UPDATE chrB antibiotic target alteration; non-erm 23S ribosomal RNA methyltransferase (G748); macrolide antibiotic; lincosamide antibiotic; model_sequences; ARO_category "UPDATED accession with AY509120.1 UPDATED category_aro_description with Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides. " 3024 UPDATE KPC-24 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2098 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin peptide antibiotic; antibiotic target alteration; 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; model_name "UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin " 524 UPDATE dfrA25 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA25 is an integron-encoded dihydrofolate reductase found in Salmonella agona. UPDATED accession with DQ267940.1 " 525 UPDATE CMY-13 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-13 is a beta-lactamase found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCTCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCATTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACTGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCACGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA UPDATED fmax with 4786 UPDATED accession with AY339625.2 UPDATED fmin with 3640 UPDATED strand with - UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAQ16660.2 UPDATED sequence with MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ " 526 UPDATE ACT-2 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACT-2 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM076977.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 527 UPDATE SHV-38 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY079099.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1018 UPDATE APH(3')-IIc antibiotic inactivation; aminoglycoside antibiotic; paromomycin; kanamycin A; APH(3'); gentamicin B; ribostamycin; G418; neomycin; butirosin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-IIc is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. UPDATED accession with HQ424460.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 521 UPDATE OXA-386 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF986254.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 522 UPDATE floR antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; florfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with floR is a plasmid or chromosome-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 and Vibrio cholerae. UPDATED partial with 0 UPDATED sequence with ATGACCACCACACGCCCCGCGTGGGCCTATACGCTGCCGGCAGCACTGCTGCTGATGGCTCCTTTCGACATCCTCGCTTCACTGGCGATGGATATTTATCTCCCTGTCGTTCCAGCGATGCCCGGCATCCTGAACACGACGCCCGCTATGATCCAACTCACGTTGAGCCTCTATATGGTGATGCTCGGCGTGGGCCAGGTGATTTTTGGTCCGCTCTCAGACAGAATCGGGCGACGGCCAATTCTACTTGCGGGCGCAACGGCTTTCGTCATTGCGTCTCTGGGAGCAGCTTGGTCTTCAACTGCACCGGCCTTTGTCGCTTTCCGTCTACTTCAAGCAGTGGGCGCGTCGGCCATGCTGGTGGCGACGTTCGCGACGGTTCGCGACGTTTATGCCAACCGTCCTGAGGGTGTCGTCATCTACGGCCTTTTCAGTTCGGTGCTGGCGTTCGTGCCTGCGCTCGGCCCTATCGCCGGAGCATTGATCGGCGAGTTCTTGGGATGGCAGGCGATATTCATTACTTTGGCTATACTGGCGATGCTCGCACTCCTAAATGCGGGTTTCAGGTGGCACGAAACCCGCCCTCTGGATCAAGTCAAGACGCGCCGATCTGTCTTGCCGATCTTCGCGAGTCCGGCTTTTTGGGTTTACACTGTCGGCTTTAGCGCCGGTATGGGCACCTTCTTCGTCTTCTTCTCGACGGCTCCCCGTGTGCTCATAGGCCAAGCGGAATATTCCGAGATCGGATTCAGCTTTGCCTTCGCCACTGTCGCGCTTGTAATGATCGTGACAACCCGTTTCGCGAAGTCCTTTGTCGCCAGATGGGGCATCGCAGGATGCGTGGCGCGTGGGATGGCGTTGCTTGTTTGCGGAGCGGTCCTGTTGGGGATCGGCGAACTTTACGGCTCGCCGTCATTCCTCACCTTCATCCTACCGATGTGGGTTGTCGCGGTCGGTATTGTCTTCACGGTGTCCGTTACCGCGAACGGCGCTTTGGCAGAGTTCGACGACATCGCGGGATCAGCGGTCGCGTTCTACTTCTGCGTTCAAAGCCTGATAGTCAGCATTGTCGGGACATTGGCGGTGGCACTTTTAAACGGTGACACAGCGTGGCCCGTGATCTGTTACGCCACGGCGATGGCGGTACTGGTTTCGTTGGGGCTGGTGCTCCTTCGGCTCCGTGGGGCTGCCACCGAGAAGTCGCCAGTCGTCTAA UPDATED fmax with 4522 UPDATED accession with AF231986.2 UPDATED fmin with 3307 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAG16656.1 UPDATED sequence with MTTTRPAWAYTLPAALLLMAPFDILASLAMDIYLPVVPAMPGILNTTPAMIQLTLSLYMVMLGVGQVIFGPLSDRIGRRPILLAGATAFVIASLGAAWSSTAPAFVAFRLLQAVGASAMLVATFATVRDVYANRPEGVVIYGLFSSVLAFVPALGPIAGALIGEFLGWQAIFITLAILAMLALLNAGFRWHETRPLDQVKTRRSVLPIFASPAFWVYTVGFSAGMGTFFVFFSTAPRVLIGQAEYSEIGFSFAFATVALVMIVTTRFAKSFVARWGIAGCVARGMALLVCGAVLLGIGELYGSPSFLTFILPMWVVAVGIVFTVSVTANGALAEFDDIAGSAVAFYFCVQSLIVSIVGTLAVALLNGDTAWPVICYATAMAVLVSLGLVLLRLRGAATEKSPVV " 523 UPDATE OXA-75 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-75 is a beta-lactamase found in A. baumannii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1014 UPDATE SHV-25 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCGCCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCGTGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AF208796.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAF37209.2 UPDATED sequence with MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1015 UPDATE evgA penam; antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; tetracycline antibiotic; cloxacillin; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1016 UPDATE OXA-255 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-255 is a beta-lactamase found in A. baumannii. UPDATED partial with 0 UPDATED sequence with ATGAAAAAATTTATACTTCCTATCTTCAGCATTTCTACTCTACTTTCTCTCAGTGCATGCTCAACTATTCAAAATAAATTTGAAAAAACTTCTGATATTTCTGATCAGCAACATGAAAAAGCCATTAAAAGCTATTTTGATGAAGCTCAAACACAAGGTGTAATAATTATTAAAGAGGGAAAGAATATTAGAATCTATGGTAATAACCTGGTACGAGCACATACAGAATATGTCCCTGCGTCAACATTTAAGATGCTAAATGCCTTAATTGGATTAGAAAATCATAAAGCTACAACAACTGAGATTTTCAAATGGGATGGTAAAAAAAGATCTTATCCTATGTGGGAAAAAGATATGACTTTAGGTGATGCCATGGCACTTTCAGCAGTTCCTGTATATCAAGAACTTGCAAGACGGACTGGCTTAGATCTAATGCAAAAAGAAGTTAAACGGGTTGGTTTTGGTAATATGAGCATCGGGACACAAGTTAATAACTTCTGGTTAGTTGGCCCCCTCAAGATTACACCAATACAAGAGGCTAATTTTGCCGATGATCTTGCGAATAATCGATTACCCTTTAAATTAGAAACTCAAGAAGAAGTAAAAAAAATGCTTCTGATTAAAGAAGTCAATGGTAGTAAAATTTATGCGAAAAGTGGATGGGGAATGGATGTGACCCCTCAAGTAGGTTGGTTAACAGGTTGGGTAGAAAAATCTAATGGCGAAAAAGTTCCCTTTTCTCTAAACCTAGAAATGAAGCAAGGAATGTCTGGTTCTATTCGTAATGAAATTACTTATAAATCATTAGAAAATTTAGGGATTATATAA UPDATED fmax with 1496 UPDATED accession with KC479325.2 UPDATED fmin with 668 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter pittii UPDATED NCBI_taxonomy_id with 48296 UPDATED NCBI_taxonomy_cvterm_id with 36787 UPDATED accession with AGK07369.1 UPDATED sequence with MKKFILPIFSISTLLSLSACSTIQNKFEKTSDISDQQHEKAIKSYFDEAQTQGVIIIKEGKNIRIYGNNLVRAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEKDMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMSIGTQVNNFWLVGPLKITPIQEANFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVTPQVGWLTGWVEKSNGEKVPFSLNLEMKQGMSGSIRNEITYKSLENLGII UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1017 UPDATE CTX-M-86 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-86 is a beta-lactamase found in Salmonella enterica. UPDATED accession with FJ214369.1 " 1010 UPDATE TEM-209 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF240808.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 529 UPDATE SHV-185 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM233164.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1012 UPDATE KPC-5 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGTCACTGTATCGCCGTCTAGTTCTGCTGTCTTGTCTCTCATGGCCGCTGGCTGGCTTTTCTGCCACCGCGCTGACCAACCTCGTCGCGGAACCATTCGCTAAACTCGAACAGGACTTTGGCGGCTCCATCGGTGTGTACGCGATGGATACCGGCTCAGGCGCAACTGTAAGTTACCGCGCTGAGGAGCGCTTCCCACTGTGCAGCTCATTCAAGGGCTTTCTTGCTGCCGCTGTGCTGGCTCGCAGCCAGCAGCAGGCCGGCTTGCTGGACACACCCATCCGTTACGGCAAAAATGCGCTGGTTCGGTGGTCACCCATCTCGGAAAAATATCTGACAACAGGCATGACGGTGGCGGAGCTGTCCGCGGCCGCCGTGCAATACAGTGATAACGCCGCCGCCAATTTGTTGCTGAAGGAGTTGGGCGGCCCGGCCGGGCTGACGGCCTTCATGCGCTCTATCGGCGATACCACGTTCCGTCTGGACCGCTGGGAGCTGGAGCTGAACTCCGCCATCCCAGGCGATGCGCGCGATACCTCATCGCCGCGCGCCGTGACGGAAAGCTTACAAAAACTGACACTGGGCTCTGCACTGGCTGCGCCGCAGCGGCAGCAGTTTGTTGATTGGCTAAAGGGAAACACGACCGGCAACCACCGCATCCGCGCGGCGGTGCCGGCAGACTGGGCAGTCGGAGACAAAACCGGAACCTGCGGAGTGTATGGCACGGCAAATGACTATGCCGTCGTCTGGCCCACTGGGCGCGCACCTATTGTGTTGGCCGTCTACACCCGGGCGCCTAACAAGGATGACAAGCACAGCGAGGCCGTCATCGCCGCTGCGGCTAGACTCGCGCTCGAGGGATTGGGCGTCAACGGGCAGTAA UPDATED fmax with 3041 UPDATED accession with EU400222.2 UPDATED fmin with 2159 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with ABY91240.1 UPDATED sequence with MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1013 UPDATE APH(2'')-IIIa antibiotic inactivation; kanamycin A; gentamicin B; aminoglycoside antibiotic; sisomicin; arbekacin; APH(2''); netilmicin; gentamicin C; amikacin; isepamicin; tobramycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(2'')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in Enterococcus gallinarum. UPDATED accession with U51479.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''. " 1234 UPDATE MIR-13 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087862.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 1236 UPDATE CMY-53 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-53 is a beta-lactamase found in Escherichia coli. UPDATED accession with HQ336940.1 " 1230 UPDATE CTX-M-33 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description "UPDATED ARO_description with CTX-M-33 is a beta-lactamase found in Salmonella enterica. " 1238 UPDATE OXA-397 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087865.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1239 UPDATE SHV-81 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCAGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 886 UPDATED accession with AM176556.2 UPDATED fmin with 25 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47136.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGSPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5672 UPDATE TTU-1 carbapenem; antibiotic inactivation; TTU beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5673 UPDATE VEB-10 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 5675 UPDATE VEB-12 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 5676 UPDATE VEB-13 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 5677 UPDATE VEB-14 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 5678 UPDATE VEB-15 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 4356 UPDATE AFM-1 carbapenem; antibiotic inactivation; AFM beta-lactamase; ARO_category "UPDATED category_aro_description with AFM beta-lactamases are class B1 beta-lactamases found in proteobacteria like Pseudomonas aeruginosa. " 4357 UPDATE AFM-2 carbapenem; antibiotic inactivation; AFM beta-lactamase; ARO_category "UPDATED category_aro_description with AFM beta-lactamases are class B1 beta-lactamases found in proteobacteria like Pseudomonas aeruginosa. " 1092 UPDATE tet(39) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AY743590.1 " 1965 UPDATE LEN-11 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with LEN-11 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 438 UPDATE VIM-6 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY165025.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 439 UPDATE SHV-83 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 1 UPDATED sequence with AAGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM176558.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47138.2 UPDATED sequence with KRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 436 UPDATE OXY-4-1 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-4-1 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AY077481.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 437 UPDATE SHV-69 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ174308.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 434 UPDATE LEN-16 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-16 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY743416.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 435 UPDATE OKP-A-9 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-9 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051148.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 433 UPDATE ACT-25 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KJ207208.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 430 UPDATE OXA-87 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ348075.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 431 UPDATE Escherichia coli marR mutant conferring antibiotic resistance penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; model_sequences; ARO_name; ARO_category "UPDATED accession with U00096.1 UPDATED ARO_name with Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 4674 UPDATE IMI-20 carbapenem; antibiotic inactivation; IMI beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 3809 UPDATE ROB-3 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3808 UPDATE ROB-2 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3805 UPDATE ParS erythromycin; penem; tetracycline antibiotic; meropenem; antibiotic efflux; imipenem; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; reduced permeability to antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; penam; Outer Membrane Porin (Opr); efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3806 UPDATE ParR erythromycin; penem; tetracycline antibiotic; meropenem; antibiotic efflux; imipenem; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; reduced permeability to antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; penam; Outer Membrane Porin (Opr); efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3801 UPDATE AAC(3)-IVb antibiotic inactivation; AAC(3); aminoglycoside antibiotic; gentamicin A; tobramycin; ARO_description "UPDATED ARO_description with A novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin. " 3800 UPDATE OXA-837 antibiotic inactivation; penam; carbapenem; cephalosporin; ampicillin; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class D OXA-like beta-lactamase described in the emerging pathogen Cupriavidus gilardii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3802 UPDATE ANT(3'')-Ib antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1630 UPDATE IMP-13 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-13 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AJ550807.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2864 UPDATE PDC-85 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 4906 UPDATE OXA-580 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2865 UPDATE PDC-86 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 5708 UPDATE VIM-59 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5709 UPDATE VIM-60 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5704 UPDATE VIM-55 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5705 UPDATE VIM-56 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5706 UPDATE VIM-57 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5707 UPDATE VIM-58 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5700 UPDATE VIM-51 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5701 UPDATE VIM-52 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5702 UPDATE VIM-53 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5703 UPDATE VIM-54 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2868 UPDATE PDC-89 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2869 UPDATE PDC-90 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 2249 UPDATE LpxA peptide antibiotic; antibiotic target alteration; colistin B; colistin A; Acinetobacter mutant Lpx gene conferring resistance to colistin; ARO_description "UPDATED ARO_description with The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. " 1907 UPDATE vanSA glycopeptide resistance gene cluster; vanS; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; vancomycin; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSA, is a vanS variant found in the vanA gene cluster. UPDATED accession with M97297.1 UPDATED model_name with vanS gene in vanA cluster UPDATED ARO_name with vanS gene in vanA cluster " 634 UPDATE smeF antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; fluoroquinolone antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with smeF is an outer membrane multidrug efflux protein of the smeDEF complex in Stenotrophomonas maltophilia. UPDATED accession with AJ252200.1 " 1851 UPDATE KPC-13 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ342889.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4682 UPDATE IMP-46 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4774 UPDATE MOX-13 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4775 UPDATE MOX-14 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4772 UPDATE MOX-11 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4773 UPDATE MOX-12 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4771 UPDATE MOX-10 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4778 UPDATE NDM-26 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase and NDM-1 variant. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4779 UPDATE NDM-30 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4174 UPDATE ACT-84 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4175 UPDATE ACT-87 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4170 UPDATE ACT-80 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4171 UPDATE ACT-81 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4172 UPDATE ACT-82 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4173 UPDATE ACT-83 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1961 UPDATE TEM-105 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF516720.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4904 UPDATE OXA-578 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4888 UPDATE OXA-559 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4889 UPDATE OXA-560 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4918 UPDATE OXA-592 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4619 UPDATE GES-36 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4618 UPDATE GES-35 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 238 UPDATE SHV-137 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ661363.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 239 UPDATE OXA-83 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-83 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ309277.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 234 UPDATE QnrS8 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrS8 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. UPDATED accession with KF730652.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 235 UPDATE OXA-181 penam; antibiotic inactivation; cephalosporin; carbapenem; piperacillin-tazobactam; amoxicillin; clavulanic acid; piperacillin; tazobactam; OXA beta-lactamase; amoxicillin-clavulanic acid; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-181 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with JN205800.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 236 UPDATE ACT-19 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KF992029.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 237 UPDATE Chryseobacterium meningosepticum BlaB carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 230 UPDATE OXA-422 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM433671.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 231 UPDATE OXA-178 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM113564.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 232 UPDATE imiH carbapenem; CphA beta-lactamase; antibiotic inactivation; model_sequences "UPDATED accession with AJ548797.1 " 233 UPDATE LEN-21 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-21 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCAGGGGTCGAACAACTGGTTCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM850911.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12349.2 UPDATED sequence with MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGVEQLVRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 993 UPDATE AAC(6')-Ib9 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ib9 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with AF043381.1 " 2228 UPDATE PEDO-1 carbapenem; antibiotic inactivation; subclass B3 PEDO beta-lactamase; model_sequences "UPDATED accession with KP109677.1 UPDATED accession with AJP77059.1 " 2229 UPDATE PEDO-2 carbapenem; antibiotic inactivation; subclass B3 PEDO beta-lactamase; model_sequences "UPDATED accession with KP109678.1 UPDATED accession with AJP77071.1 " 2227 UPDATE VCC-1 carbapenem; monobactam; VCC beta-lactamase; antibiotic inactivation; penam; model_sequences; ARO_category "UPDATED accession with KT818596.1 UPDATED accession with ALU64000.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2224 UPDATE Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem penam; carbapenem; imipenem; penem; reduced permeability to antibiotic; Outer Membrane Porin (Opr); cephalosporin; cephamycin; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 992 UPDATE SHV-66 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ174306.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2222 UPDATE VEB-1b antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 2223 UPDATE MexZ erythromycin; arbekacin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category; model_name "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 UPDATED model_name with MexZ " 1 UPDATE PDC-4 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED accession with FJ666067.1 " 2705 UPDATE MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; trimethoprim; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; ciprofloxacin; fluoroquinolone antibiotic; phenicol antibiotic; chloramphenicol; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 1433 UPDATE CMY-18 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-18 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY743434.1 " 133 UPDATE arr-8 antibiotic inactivation; rifampin; rifapentine; rifabutin; rifampin ADP-ribosyltransferase (Arr); rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with arr-8 is an integron-encoded ribosyltransferase found in Klebsiella oxytoca. UPDATED accession with KC199968.1 " 4881 UPDATE OXA-552 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2707 UPDATE MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; trimethoprim; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; fluoroquinolone antibiotic; phenicol antibiotic; chloramphenicol; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 146 UPDATE OXA-98 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-98 is a beta-lactamase found in A. baumannii. UPDATED accession with AM279652.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 144 UPDATE IMP-12 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-12 is a beta-lactamase found in Pseudomonas putida. UPDATED accession with AJ420864.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 145 UPDATE OXA-229 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-229 is a beta-lactamase found in A. bereziniae. UPDATED accession with JQ422052.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 142 UPDATE tet(E) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with L06940.1 " 140 UPDATE AAC(6')-IIb AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-IIb is an integron-encoded aminoglycoside acetyltransferase in P. fluorescens. UPDATED accession with L06163.1 " 4884 UPDATE OXA-555 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1052 UPDATE OXA-206 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB634250.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 148 UPDATE SHV-92 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ836922.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 149 UPDATE aadA12 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA12 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli, Yersinia enterocolitica and S. enterica. UPDATED accession with FJ381668.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1055 UPDATE Escherichia coli parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description "UPDATED ARO_description with Point mutation in Escherichia coli parE resulting in fluoroquinolones resistance. " 120 UPDATE aadA4 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA4 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Bordetella parapertussis and E. coli. UPDATED accession with AY138986.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 2088 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin antibiotic target alteration; streptomycin; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_name "UPDATED ARO_description with Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to streptomycin. UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin " 1056 UPDATE VIM-19 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-19 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with FJ822963.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 121 UPDATE mdtF penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; cloxacillin; fluoroquinolone antibiotic; erythromycin; model_sequences; ARO_category "UPDATED accession with U00096.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2083 UPDATE Mycoplasma hominis parC conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutation in Mycoplasma hominis parC resulting in fluoroquinolone resistance. UPDATED model_name with Mycoplasma hominis parC conferring resistance to fluoroquinolones " 2080 UPDATE Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' major domain of the rrsH 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin " 2086 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline tetracycline antibiotic; antibiotic target alteration; 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' major domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline " 2087 UPDATE aadA13 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; ARO_category "UPDATED ARO_description with aadA13 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in Pseudomonas rettgeri, P. aeruginosa, Y. enterocolitica and E. coli. UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 2084 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to amikacin antibiotic target alteration; amikacin; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to amikacin. " 2085 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' major domain of helix 35, in the rrnB gene operon for 16S rRNA of Escherichia coli can confer resistance to spectinomycin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin " 3342 UPDATE dfrA3b trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with A dihydrofolate reductase that confers resistance to trimethoprim. UPDATED partial with 0 UPDATED sequence with ATGACTAAACAAGCAATATTTGCCGTAGCCGAGAACCTAGCCTTCGGGCTAGGTGGGGGTCTCCCTTGGGATACGCTGAAAGACGACTTACAATTCTTTAAGAGGCTAACTGAAGGGACTGACTTAGTAATGGGAGCCTCCACGTACAGAACGCTGCCATTGTTACCAACCAATAACAGACAGTTTATTGTGGTAAGCAATACTGAGGAGCCTAGCCTTAATGTTCATGTGGTATCTCCAGAACACTTCAAGGCTTTCCTTAGCAAAACTTCCAGAAACCTTACTATTATCGGGGGCAGCTCGTTACTAACGGTAGATATATTATCAAAAATGGATAAGATAATTATGACTACGGTGTATGGAAGTTTTGATGCAGATGTATACTTACCTACTGAAGTAGTAAGTTATGTTACTGGCAAAGCTTCAAACGCCACATTATTTAATAACTCGGACGCAAAGATGGCAGTTTATTATGGATAA UPDATED fmax with 6095 UPDATED accession with AY162283.2 UPDATED fmin with 5615 UPDATED strand with + UPDATED NCBI_taxonomy_name with Citrobacter freundii UPDATED NCBI_taxonomy_id with 546 UPDATED NCBI_taxonomy_cvterm_id with 36915 UPDATED accession with AAN85115.1 UPDATED sequence with MTKQAIFAVAENLAFGLGGGLPWDTLKDDLQFFKRLTEGTDLVMGASTYRTLPLLPTNNRQFIVVSNTEEPSLNVHVVSPEHFKAFLSKTSRNLTIIGGSSLLTVDILSKMDKIIMTTVYGSFDADVYLPTEVVSYVTGKASNATLFNNSDAKMAVYYG " 3343 UPDATE dfrA6 from Proteus mirabilis trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with dfrA6 is a dihydrofolate reductase that confers resistance to trimethoprim. Found in Proteus mirabilis. " 124 UPDATE IND-7 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-7 is a beta-lactamase found in Chryseobacterium indologenes. UPDATED accession with AB529520.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 3340 UPDATE aacA43 AAC(6'); kanamycin A; antibiotic inactivation; aminoglycoside antibiotic; tobramycin; ARO_description "UPDATED ARO_description with aacA43 is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae. " 2712 UPDATE MexXY-OprA antibiotic efflux; tobramycin; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; meropenem; macrolide antibiotic; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; arbekacin; ciprofloxacin; tetracycline antibiotic; gentamicin C; amikacin; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_description; model_description "UPDATED ARO_description with MexXY-OprA is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprA is the outer membrane channel. MexXY-OprA is associated with resistance to aminoglycosides. UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 2713 UPDATE MexXY-OprM erythromycin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3341 UPDATE Erm(K) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with A 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K) [Alkalihalobacillus halodurans]. UPDATED NCBI_taxonomy_name with Alkalihalobacillus halodurans " 3346 UPDATE AQU-2 antibiotic inactivation; AQU beta-lactamase; cephalosporin; ARO_description "UPDATED ARO_description with AQU-2 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from Aeromonas. " 127 UPDATE clbB dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with clbB is a plasmid-encoded cfr gene found in Bacillus brevis. UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 3347 UPDATE AQU-3 antibiotic inactivation; AQU beta-lactamase; cephalosporin; ARO_description "UPDATED ARO_description with AQU-3 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from. " 128 UPDATE srmB pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; spiramycin; phenicol antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with srmB is an ABC-F subfamily protein found in Streptomyces ambofaciens that confers resistance to spiramycin. UPDATED accession with X63451.1 " 5078 UPDATE OXA-769 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5079 UPDATE OXA-770 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5072 UPDATE OXA-763 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5073 UPDATE OXA-764 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5070 UPDATE OXA-761 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5071 UPDATE OXA-762 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5076 UPDATE OXA-767 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5077 UPDATE OXA-768 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5074 UPDATE OXA-765 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5075 UPDATE OXA-766 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1832 UPDATE QnrS2 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrS2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. UPDATED accession with DQ485530.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1833 UPDATE OXA-374 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF986255.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1830 UPDATE APH(3'')-Ib antibiotic inactivation; APH(3''); streptomycin; aminoglycoside antibiotic; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with TTGAATCGAACTAATATTTTTTTTGGTGAATCGCATTCTGACTGGTTGCCTGTCAGAGGCGGAGAATCTGGTGATTTTGTTTTTCGACGTGGTGACGGGCATGCCTTCGCGAAAATCGCACCTGCTTCCCGCCGCGGTGAGCTCGCTGGAGAGCGTGACCGCCTCATTTGGCTCAAAGGTCGAGGTGTGGCTTGCCCCGAGGTGATCAACTGGCAGGAGGAACAGGAGGGTGCATGCTTGGTGATAACGGCAATTCCGGGAGTACCGGCGGCTGATCTGTCTGGAGCGGATTTGCTCAAAGCGTGGCCGTCAATGGGGCAGCAACTTGGCGCTGTTCACAGCCTATTGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGGACGCGCCGTTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCAGCTCGATCTTTTGGCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGATCCCTGCATGCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGCAGATCGCTATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCTTCGCTGTCCTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTGACTTGGGGTTGA UPDATED fmax with 16397 UPDATED accession with AF313472.2 UPDATED fmin with 15593 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with ABK33456.1 UPDATED sequence with MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLLVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG UPDATED category_aro_description with Phosphorylation of streptomycin on the hydroxyl group at position 3''. " 1831 UPDATE AAC(6')-Iid AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iid is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus durans. UPDATED partial with 0 UPDATED sequence with ATGATTATCAGTGAGTTTGATCGTGAGAATATTGTCTTGCGAGATCAGCTTGCAGATCTTTTAAGATTGACTTGGCCTGATGAGTATGGAACAGAGCCGATGAAAGAAGTCGAACAGTTGATGGCTCCAGAACGGATTGCTGTATCGGCGATTGAAGGGGAGGAATTGGTCGGTTTTGTTGGAGCGATCCCTCAATATGGCAAAACAGGGTGGGAGTTACATCCTTTGGTAGTAGCAAGCACACATCGCAAACAACAAATCGGGACACGATTGGTTTCCTACCTGGAAAAAGAAGTCGCTTCATATGGTGGCCTGGTCATCTATCTAGGGACAGATGATGTTGAAGGACAAACAAATTTAGTTGAAACGGATTTATTTGAAGATACCTTTGCAAAGTTACAAGAAATCAAAAATATCAATCATCATCCCTATACATTTTATGAGAAACTTGGCTATCAGATCATCGGTGTGATCCCAGATGCGAATGGGTGGAACCAGCCTGATATTTGGTTAGCAAAACGAGTGGCCAAACGAGAGCCAACGGAATAA UPDATED fmax with 582 UPDATED accession with AJ584700.2 UPDATED fmin with 33 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterococcus hirae UPDATED NCBI_taxonomy_id with 1354 UPDATED NCBI_taxonomy_cvterm_id with 39521 UPDATED accession with CAE50925.1 UPDATED sequence with MIISEFDRENIVLRDQLADLLRLTWPDEYGTEPMKEVEQLMAPERIAVSAIEGEELVGFVGAIPQYGKTGWELHPLVVASTHRKQQIGTRLVSYLEKEVASYGGLVIYLGTDDVEGQTNLVETDLFEDTFAKLQEIKNINHHPYTFYEKLGYQIIGVIPDANGWNQPDIWLAKRVAKREPTE " 1836 UPDATE OXA-201 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-201 is a beta-lactamase found in A. baumannii. UPDATED accession with HQ734812.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1834 UPDATE TEM-94 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ318094.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1835 UPDATE tet(38) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AY825285.1 " 3794 UPDATE LpsA peptide antibiotic; reduced permeability to antibiotic; Intrinsic peptide antibiotic resistant Lps; ARO_category "UPDATED category_aro_description with LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins. " 1839 UPDATE aadA14 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; ARO_category "UPDATED ARO_description with aadA14 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in Pasteurella multocida. UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 3790 UPDATE MecC-type methicillin resistance repressor MecI penam; methicillin resistant PBP2; antibiotic target replacement; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3793 UPDATE LpsB peptide antibiotic; reduced permeability to antibiotic; Intrinsic peptide antibiotic resistant Lps; ARO_category "UPDATED category_aro_description with LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins. " 2404 UPDATE Neisseria gonorrhoeae gyrA conferring resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrA; ciprofloxacin; ARO_description "UPDATED ARO_description with Point mutation in Neisseria gonorrhoeae DNA gyrase subunit A. Decreases affinity between fluoroquinolone antibiotic molecule and gyrA, thereby conferring resistance to fluoroquinolone. " 2405 UPDATE Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone resistant parC; fluoroquinolone antibiotic; ciprofloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutations in Neisseria gonorrhoeae parC protein that confer resistance to fluoroquinolone by reducing affinity to antibiotic binding site. UPDATED model_name with Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones " 4985 UPDATE OXA-669 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4987 UPDATE OXA-674 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4986 UPDATE OXA-670 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4989 UPDATE OXA-676 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4988 UPDATE OXA-675 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 931 UPDATE OXA-316 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-316 is a beta-lactamase found in A. baumannii. UPDATED accession with KF057033.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2158 UPDATE Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin antibiotic target alteration; elfamycin antibiotic; pulvomycin; elfamycin resistant EF-Tu; ARO_description "UPDATED ARO_description with Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin. " 936 UPDATE OKP-A-13 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-13 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with FJ534513.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 935 UPDATE OXA-314 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-314 is a beta-lactamase found in A. baumannii. UPDATED accession with KF057031.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 934 UPDATE IMP-8 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-8 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGAAGAAATTATTTGTTTTATGTGTATGCTTCCTTTGTAGCATTACTGCCGCAGGAGCGGCTTTGCCTGATTTAAAAATCGAGAAGCTTGAAGAAGGTGTTTATGTTCATACATCGTTCGAAGAAGTTAACGGTTGGGGTGTTGTTTCTAAACACGGTTTGGTGGTTCTTGTAAACACTGACGCCTATCTGATTGACACTCCATTTACTGCTACAGATACTGAAAAGTTAGTCAATTGGTTTGTGGAGCGCGGCTATAAAATCAAAGGCACTATTTCCTCACATTTCCATAGCGACAGCACAGGGGGAATAGAGTGGCTTAATTCTCAATCTATTCCCACGTATGCATCTGAATTAACAAATGAACTTCTTAAAAAAGACGGTAAGGTGCAAGCTAAAAACTCATTTAGCGGAGTTAGTTATTGGCTAGTTAAAAATAAAATTGAAGTTTTTTATCCCGGCCCGGGGCACACTCAAGATAACGTAGTGGTTTGGTTACCTGAAAAGAAAATTTTATTCGGTGGTTGTTTTGTTAAACCGGACGGTCTTGGTAATTTGGGTGACGCAAATTTAGAAGCTTGGCCAAAGTCCGCCAAAATATTAATGTCTAAATATGGTAAAGCAAAACTGGTTGTTTCAAGTCATAGTGAAATTGGGGACGCATCACTCTTGAAACGTACATGGGAACAGGCTGTTAAAGGGCTAAATGAAAGTAAAAAACCATCACAGCCAAGTAACTAA UPDATED fmax with 2822 UPDATED accession with AF322577.2 UPDATED fmin with 2081 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAK13430.1 UPDATED sequence with MKKLFVLCVCFLCSITAAGAALPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEIGDASLLKRTWEQAVKGLNESKKPSQPSN UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1955 UPDATE OXA-29 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-29 is a beta-lactamase found in Legionella gormanii. UPDATED accession with AJ400619.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1954 UPDATE TEM-154 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ807656.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1957 UPDATE VIM-18 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-18 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AM778091.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1956 UPDATE IMI-1 carbapenem; antibiotic inactivation; IMI beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with IMI-1 is a beta-lactamase found in Enterobacter cloacae. UPDATED accession with U50278.1 " 1951 UPDATE TEM-76 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF190694.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1950 UPDATE arr-1 antibiotic inactivation; rifampin; rifapentine; rifabutin; rifampin ADP-ribosyltransferase (Arr); rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with arr-1 is a chromosome-encoded ribosyltransferase found in Mycolicibacterium smegmatis. UPDATED accession with AF001493.1 " 1953 UPDATE SHV-155 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121122.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1952 UPDATE OXA-1 penam; antibiotic inactivation; cephalosporin; carbapenem; piperacillin-tazobactam; cefalotin; amoxicillin; ampicillin; clavulanic acid; piperacillin; tazobactam; OXA beta-lactamase; amoxicillin-clavulanic acid; ARO_description; ARO_category "UPDATED ARO_description with OXA-1 is a beta-lactamase found in E. coli. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1829 UPDATE CMY-87 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with AB699171.1 " 1959 UPDATE ACT-7 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with FJ237368.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1958 UPDATE VIM-33 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-33 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with JX258134.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1828 UPDATE GES-6 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-6 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY494718.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 569 UPDATE OXA-228 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-228 is a beta-lactamase found in A. bereziniae. UPDATED accession with JQ422053.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 132 UPDATE TEM-198 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB700703.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 905 UPDATE CTX-M-93 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-93 is a beta-lactamase found in Escherichia coli. UPDATED accession with HQ166709.1 " 1992 UPDATE dfrA1 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with dfrA1 is an integron-encoded dihydrofolate reductase. " 1825 UPDATE CTX-M-27 penam; carbapenem; antibiotic inactivation; piperacillin-tazobactam; cephalosporin; cefazolin; ceftazidime; cefalotin; amoxicillin-clavulanic acid; amoxicillin; ampicillin; clavulanic acid; piperacillin; tazobactam; cefixime; ertapenem; CTX-M beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CTX-M-27 is a beta-lactamase found in Escherichia coli. UPDATED accession with AY156923.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 829 UPDATE DHA-17 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087850.1 " 828 UPDATE TEM-83 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF427129.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1824 UPDATE oleI antibiotic inactivation; ole glycosyltransferase; macrolide antibiotic; oleandomycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGACGAGCGAGCACCGCTCTGCCTCCGTGACACCCCGTCACATCTCCTTCTTCAACATCCCCGGCCACGGCCACGTGAACCCGTCACTCGGCATCGTCCAGGAACTGGTCGCGCGCGGCCACCGGGTCAGCTACGCCATCACCGACGAGTTCGCCGCACAGGTCAAGGCGGCCGGCGCGACGCCCGTGGTGTACGACTCCATCCTGCCGAAGGAGTCCAACCCCGAGGAGTCGTGGCCGGAGGACCAGGAGTCCGCGATGGGCCTGTTCCTCGACGAAGCCGTCCGGGTCCTGCCGCAGCTGGAGGACGCCTACGCCGACGACCGGCCGGACCTGATCGTCTACGACATCGCCTCCTGGCCCGCCCCGGTGCTCGGCCGGAAGTGGGACATCCCCTTCGTCCAGCTCTCCCCGACCTTCGTCGCCTACGAGGGCTTCGAGGAGGACGTACCCGCGGTGCAGGACCCCACGGCCGACCGCGGCGAGGAGGCCGCCGCCCCCGCGGGGACCGGGGACGCCGAGGAGGGTGCCGAGGCCGAGGACGGCCTGGTGCGCTTCTTCACCCGGCTCTCGGCCTTCCTGGAGGAGCACGGGGTGGACACCCCGGCCACCGAGTTCCTCATCGCGCCCAACCGCTGCATCGTCGCGCTGCCGCGCACCTTCCAGATCAAGGGCGACACGGTCGGCGACAACTACACCTTCGTCGGTCCCACCTACGGCGACCGGTCCCACCAGGGCACCTGGGAAGGCCCCGGGGACGGGCGTCCGGTGCTGCTGATCGCCCTGGGCTCGGCGTTCACCGACCACCTCGACTTCTACCGCACCTGCCTGTCCGCCGTCGACGGCCTGGACTGGCACGTGGTGCTCTCCGTGGGCCGCTTCGTCGACCCCGCGGACCTCGGCGAGGTCCCGCCGAACGTCGAGGTGCACCAGTGGGTGCCGCAGCTCGACATCCTGACCAAAGCCTCCGCGTTCATCACGCACGCGGGCATGGGCAGCACCATGGAGGCCCTGTCGAACGCGGTGCCCATGGTCGCGGTGCCGCAGATCGCGGAGCAGACGATGAACGCCGAGCGGATCGTCGAGCTGGGCCTCGGCCGGCACATCCCGCGGGACCAGGTCACGGCCGAGAAGCTGCGCGAGGCCGTGCTCGCCGTCGCCTCCGACCCCGGTGTCGCCGAACGGCTCGCGGCCGTCCGGCAGGAGATCCGTGAGGCGGGCGGCGCCCGGGCGGCCGCCGACATCCTGGAGGGCATCCTCGCCGAAGCAGGCTGA UPDATED fmax with 1275 UPDATED accession with DQ195535.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Streptomyces antibioticus UPDATED NCBI_taxonomy_id with 1890 UPDATED NCBI_taxonomy_cvterm_id with 36823 UPDATED accession with ABA42118.2 UPDATED sequence with MTSEHRSASVTPRHISFFNIPGHGHVNPSLGIVQELVARGHRVSYAITDEFAAQVKAAGATPVVYDSILPKESNPEESWPEDQESAMGLFLDEAVRVLPQLEDAYADDRPDLIVYDIASWPAPVLGRKWDIPFVQLSPTFVAYEGFEEDVPAVQDPTADRGEEAAAPAGTGDAEEGAEAEDGLVRFFTRLSAFLEEHGVDTPATEFLIAPNRCIVALPRTFQIKGDTVGDNYTFVGPTYGDRSHQGTWEGPGDGRPVLLIALGSAFTDHLDFYRTCLSAVDGLDWHVVLSVGRFVDPADLGEVPPNVEVHQWVPQLDILTKASAFITHAGMGSTMEALSNAVPMVAVPQIAEQTMNAERIVELGLGRHIPRDQVTAEKLREAVLAVASDPGVAERLAAVRQEIREAGGARAAADILEGILAEAG " 825 UPDATE SHV-20 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF117744.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 824 UPDATE vanD glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; model_sequences; ARO_category "UPDATED accession with AY082011.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 827 UPDATE QnrB55 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB55 is a plasmid-mediated quinolone resistance protein found in Raoultella terrigena. UPDATED accession with KF730650.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 826 UPDATE TolC tetracycline; erythromycin; penem; tetracycline antibiotic; piperacillin; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; nalidixic acid; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; cefalotin; spectinomycin; oxacillin; ciprofloxacin; cloxacillin; gentamicin C; streptomycin; aminoglycoside antibiotic; disinfecting agents and antiseptics; polymyxin B3; polymyxin B1; glycylcycline; rifamycin antibiotic; imipenem; peptide antibiotic; rifampin; ticarcillin; ampicillin; ertapenem; penam; triclosan; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; polymyxin B2; tigecycline; polymyxin B4; cephamycin; fluoroquinolone antibiotic; tobramycin; phenicol antibiotic; azithromycin; chloramphenicol; model_sequences; model_name; ARO_category "UPDATED accession with FJ768952.1 UPDATED model_name with TolC UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 821 UPDATE Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin antibiotic target alteration; rifamycin-resistant arabinosyltransferase; rifampin; rifamycin antibiotic; ARO_description; model_sequences; model_name "UPDATED ARO_description with Specific mutations that occurs on Mycobacterium tuberculosis embB causing it to be rifampicin resistant. UPDATED accession with AE000516.1 UPDATED model_name with Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin " 820 UPDATE mdtB efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; aminocoumarin antibiotic; resistance-nodulation-cell division (RND) antibiotic efflux pump; novobiocin; model_sequences "UPDATED accession with U00096.1 " 822 UPDATE QnrD1 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrD1 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. UPDATED accession with FJ228229.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1826 UPDATE ykkC antibiotic efflux; small multidrug resistance (SMR) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; streptomycin; aminoglycoside antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with ykkC is an SMR-type protein that is a subunit of the ykkCD efflux pump. UPDATED accession with AL009126.1 " 1536 UPDATE OXA-421 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4258 UPDATE ADC-193 antibiotic inactivation; cephalosporin; ADC beta-lactamases pending classification for carbapenemase activity; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1821 UPDATE AAC(6')-Ir AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ir is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter colistiniresistens. UPDATED accession with AF031326.1 " 618 UPDATE emeA efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; multidrug and toxic compound extrusion (MATE) transporter; acriflavine; disinfecting agents and antiseptics; model_sequences; ARO_category "UPDATED accession with AB091338.1 UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 1483 UPDATE AAC(3)-Xa kanamycin A; antibiotic inactivation; AAC(3); aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(3)-Xa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces griseus. " 1482 UPDATE SME-1 carbapenem; antibiotic inactivation; SME beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with SME-1 is a beta-lactamase found in Serratia marcescens. UPDATED accession with Z28968.1 " 1481 UPDATE OXY-1-4 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-1-4 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AY077483.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1480 UPDATE EXO-1 penam; antibiotic inactivation; EXO beta-lactamase; ARO_description; model_sequences; model_name; ARO_category "UPDATED ARO_description with Class A beta-lactamase found in Streptomyces albus G. UPDATED accession with M28303.1 UPDATED model_name with EXO-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1485 UPDATE MOX-8 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; model_sequences; ARO_category "UPDATED accession with JX173956.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1484 UPDATE ACT-27 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KJ207209.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3301 UPDATE LnuP antibiotic inactivation; lincosamide nucleotidyltransferase (LNU); lincosamide antibiotic; ARO_description "UPDATED ARO_description with LnuP is a lincosamide nucleotidyltransferase major efflux facilitator. " 1713 UPDATE vanYM glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanYM, is a vanY variant found in the vanM gene cluster. UPDATED accession with FJ349556.1 UPDATED model_name with vanY gene in vanM cluster UPDATED ARO_name with vanY gene in vanM cluster " 1712 UPDATE IMP-41 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with AB753458.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 794 UPDATE Staphylococcus aureus rpoC conferring resistance to daptomycin peptide antibiotic; antibiotic target alteration; daptomycin-resistant beta prime subunit of RNA polymerase (rpoC); daptomycin; ARO_description "UPDATED ARO_description with Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin. " 793 UPDATE IMP-34 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAGCAAGTTATCTGTATTCTTTATATTTTTGTTTTGCAGCATTGCTACCGCAGCAGAGTCTTTGCCAGATTTAAAAATTGAAAAGCTTGATGAAGGCGTTTATGTTCATACTTCGTTTGAAGAAGTTAACGGGTGGGGCGTTGTTCCTAAACATGGTTTGGTGGTTCTTGTAAATGCTGAGGCTTATTTAATTGACACTCCATTTACGGCTAAAGATACTGAAAAGTTAGTCACTTGGTTTGTGGAGCGTGGCTATAAAATAAAAGGCAGTATTTCCTCTCATTTTCATAGCGACAGCACGGGCGGAATAGGGTGGCTTAATTCTCGATCTATCCCCACGTATGCATCTGAATTAACAAATGAACTGCTTAAAAAAGACGGTAAGGTTCAAGCCACAAATTCATTTAGCGGAGTTAACTATTGGCTAGTTAAAAATAAAATTGAAGTTTTTTATCCAGGCCCGGGACACACTCCAGATAACGTAGTGGTTTGGCTGCCTGAAAGGAAAATATTATTCGGTGGTTGTTTTATTAAACCGTACGGTTTAGGCAATTTGGGTGACGCAAATATAGAAGCTTGGCCAAAGTCCGCCAAATTATTAAAGTCCAAATATGGTAAGGCAAAACTGGTTGTTCCAAGTCACAGTGAAGTTGGAGACGCATCACTCTTGAAACTTACATTAGAGCAGGCGGTTAAAGGATTAAACGAAAGTAAAAAACCATCAAAACCAAGCAACTAA UPDATED fmax with 27966 UPDATED accession with AB715422.2 UPDATED fmin with 27225 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella oxytoca UPDATED NCBI_taxonomy_id with 571 UPDATED NCBI_taxonomy_cvterm_id with 36788 UPDATED accession with BAP75826.1 UPDATED sequence with MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIGWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 792 UPDATE OXY-1-1 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-1-1 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with Z30177.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 791 UPDATE SHV-14 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF226622.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1719 UPDATE ceoA efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; aminoglycoside antibiotic; resistance-nodulation-cell division (RND) antibiotic efflux pump; antibiotic efflux; ARO_description; model_sequences "UPDATED ARO_description with ceoA is a periplasmic linker subunit of the CeoAB-OpcM efflux pump. UPDATED accession with U97042.1 " 799 UPDATE CTX-M-31 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-31 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AJ567481.1 " 798 UPDATE cmeC antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; cefotaxime; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; fluoroquinolone antibiotic; fusidic acid; erythromycin; model_sequences "UPDATED accession with AB894099.1 " 1270 UPDATE QnrS3 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrS3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED accession with EU077611.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 2412 UPDATE Shigella flexneri parC conferring resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone resistant parC; nalidixic acid; fluoroquinolone antibiotic; norfloxacin; ARO_description "UPDATED ARO_description with Point mutation in parC conferring resistance to fluoroquinolone antibiotics in Shigella flexneri,. " 4399 UPDATE BlaB-38 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1271 UPDATE AAC(6')-Iw AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; model_sequences "UPDATED accession with AF031331.1 " 2143 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin antibiotic target alteration; gentamicin C; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to gentamicin. " 1290 UPDATE TEM-141 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY956335.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 610 UPDATE SHV-153 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121120.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1715 UPDATE OXA-73 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-73 is a beta-lactamase found in Klebsiella pneumonia. UPDATED accession with AY762325.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2142 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin peptide antibiotic; antibiotic target alteration; 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; model_name "UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin " 1139 UPDATE dfrA12 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. " 137 UPDATE APH(2'')-Ie antibiotic inactivation; kanamycin A; gentamicin B; aminoglycoside antibiotic; sisomicin; arbekacin; APH(2''); netilmicin; gentamicin C; amikacin; isepamicin; tobramycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(2'')-Ie is a plasmid or transposon-encoded aminoglycoside phosphotransferase in E. faecium and E. casseliflavus. UPDATED accession with AY939911.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''. " 1133 UPDATE SHV-109 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU418913.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1995 UPDATE AAC(6')-Iz AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iz is a chromosomal-encoded aminoglycoside acetyltransferase in S. maltophilia. UPDATED accession with AF140221.1 " 1131 UPDATE AAC(3)-Ic antibiotic inactivation; AAC(3); sisomicin; gentamicin B; gentamicin C; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-Ic is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with AJ511268.1 " 1130 UPDATE PDC-9 antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; PDC beta-lactamase; monobactam; model_sequences "UPDATED accession with FJ666072.1 " 1137 UPDATE TEM-90 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF351241.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1136 UPDATE MIR-6 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ664733.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 1135 UPDATE Staphylococcus aureus parE conferring resistance to aminocoumarin aminocoumarin resistant parE; clorobiocin; aminocoumarin antibiotic; novobiocin; coumermycin A1; antibiotic target alteration; ARO_description "UPDATED ARO_description with Point mutation in Staphylococcus aureus parE resulting in aminocoumarin resistance. " 617 UPDATE OXA-147 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-147 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with FJ848783.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 920 UPDATE TEM-152 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ834728.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2061 UPDATE VIM-7 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-7 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AJ536835.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 922 UPDATE AAC(6')-30/AAC(6')-Ib' fusion protein AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-30/AAC(6')-Ib' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGACATTCCTGATCCGACCCGTAGAACAAAGTGACGCTGAATCTTGGGAGCGCTTACGCAACCTTTTGTGGGAGGGCGACGACCACAAAAGCGAGATCACACAATTCTTCAACGGCGAAGTAGAAGAACCCAATGAAGTGTTGCTTGCCGTAACCGAAGAAAATGATGCAATAGCGCACATCGAGCTATCGTTGAGGTATGACATTGATGGCTTGACGGGCATCAAGACCGGTTACATCGAAGGCCTTTTTGTAGAGGAGCGGCACCGTGCCGCAGGTGTAGTCCTCAAGCTATTGCGAGCCGCAGAGTTCTGGGCAAGAGATCAAGGATGTCTGGCGTTTGCCTCAGACAGGGATGATCGTGTCATCATCTATGCTCGCTACACGGGAGCGCCACCTAACAATTCATTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA UPDATED fmax with 2913 UPDATED accession with AJ584652.2 UPDATED fmin with 1926 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with CAE48335.2 UPDATED sequence with MTFLIRPVEQSDAESWERLRNLLWEGDDHKSEITQFFNGEVEEPNEVLLAVTEENDAIAHIELSLRYDIDGLTGIKTGYIEGLFVEERHRAAGVVLKLLRAAEFWARDQGCLAFASDRDDRVIIYARYTGAPPNNSLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA " 328 UPDATE Salmonella enterica cmlA antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmlA is a plasmid-encoded chloramphenicol exporter that is found in Salmonella typhimurium. UPDATED partial with 0 UPDATED sequence with ATGGACATGTACTTGCCAGCAGTGCCGTTTATGCCAAACGCGCTTGGTACGACAGCGAGCACAATTCAGCTTACGCTGACAACGTACTTGGTCATGATTGGTGCCGGTCAGCTCTTGTTTGGACCGCTATCGGACCGACTGGGGCGCCGCCCCGTTCTACTGGGAGGTGGCCTCGCAAACGTTGTGGCGTCAATGGGCCTCGCTCTTACGTCATCGGCTGAAGTCTTTCTGGGGCTTCGGATTCTTCAGGCTTGTGGTGCCTCGGCGTGCCTTGTTTCCACATTTGCAACAGTACGTGACATTTACGCAGGTCGCGAGGAAAGTAATGTCATTTACGGCATACTCGGATCCATGCTGGCCATGGTCCCGGCGGTAGGCCCATTGCTCGGAGCGCTCGTCGACATGTGGCTTGGGTGGCGGGCTATCTTTGCGTTTCTAGGTTTGGGCATGATCGCTGCATCTGCAGCAGCGTGGCGATTCTGGCCTGAAACCCGGGTGCAACGAGTTGCGGGCTTGCAATGGTCGCAGCTGCTACTCCCCGTTAAGTGCCTGAACTTCTGGTTGTACACGTTGTGTTACGCCGCTGGAATGGGTAGCTTCTTCGTCTTTTTCTCCATTGCGCCCGGACTAATGATGGGCAGGCAAGGTGTGTCTCAGCTTGGCTTCAGCCTGCTGTTCGCCACAGTGGCAATTGCCATGGTGTTTACGGCTCGTTTTATGGGGCGTGTGATACCCAAGTGGGGCAGCCCAAGTGTCTTGCGAATGGGAATGGGATGCCTGATAGCTGGAGCAGTATTGCTTGCCATCACCGAAATATGGGCTTTGCAGTCCGTGTTAGGCTTTATTGCTCCAATGTGGCTAGTGGGTATTGGTGTCGCCACAGCGGTATCTGTGGCGCCCAATGGCGCTCTTCGAGGATTCGACCATGTTGCTGGAACGGTCACGGCAGTCTACTTCTGCTTGGGCGGTGTACTGCTAGGAAGCATCGGAACGTTGATCATTTCGCTGTTGCCGCGCAACACGGCTTGGCCGGTTGTCGTGTACTGTTTGACCCTTGCAACAGTCGTGCTCGGTCTGTCTTGTGTTTCCCGAGTGAAGGGCTCTCGCGGCCAGGGGGAGCATGATGTGGTCGCGCTACAAAGTGCGGGAAGTACATCAAATCCCAATCGTTGA UPDATED fmax with 2858 UPDATED accession with AJ487033.2 UPDATED fmin with 1685 UPDATED strand with + UPDATED NCBI_taxonomy_name with Salmonella enterica subsp. enterica serovar Typhimurium UPDATED NCBI_taxonomy_id with 90371 UPDATED NCBI_taxonomy_cvterm_id with 35732 UPDATED accession with CAD31707.1 UPDATED sequence with MDMYLPAVPFMPNALGTTASTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLGGGLANVVASMGLALTSSAEVFLGLRILQACGASACLVSTFATVRDIYAGREESNVIYGILGSMLAMVPAVGPLLGALVDMWLGWRAIFAFLGLGMIAASAAAWRFWPETRVQRVAGLQWSQLLLPVKCLNFWLYTLCYAAGMGSFFVFFSIAPGLMMGRQGVSQLGFSLLFATVAIAMVFTARFMGRVIPKWGSPSVLRMGMGCLIAGAVLLAITEIWALQSVLGFIAPMWLVGIGVATAVSVAPNGALRGFDHVAGTVTAVYFCLGGVLLGSIGTLIISLLPRNTAWPVVVYCLTLATVVLGLSCVSRVKGSRGQGEHDVVALQSAGSTSNPNR " 923 UPDATE VIM-25 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM750249.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3013 UPDATE ADC-68 carbapenem; antibiotic inactivation; ADC beta-lactamase with carbapenemase activity; ARO_description "UPDATED ARO_description with A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii. " 3014 UPDATE IMP-55 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3015 UPDATE IMP-56 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; ARO_category "UPDATED ARO_description with An IMP class B metallo-beta-lactamase enzyme identified from carbapenem-resistant Pseudomonas aeruginosa. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 519 UPDATE VIM-26 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FR748153.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 518 UPDATE vanXYN glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanXY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXYN, is a vanXY variant found in the vanN gene cluster. UPDATED partial with 0 UPDATED sequence with ATGCATAATTTTTATTTACAGCTTGTAAACCAACAACACCCTTGGAAATCATTTAATCATTCGCCACAGCTTGTTCAAGCGACCTATGCGGAAGAAAAGATTTTAATAGATTCCAAGGTTAACCATCAATTCAATCAGTTACTTGAAACACTACAATTAACTGATCGCATCATGATCGTTGATGGTCATCGAACGGTTGCTGAGCAAAAACATTTGTGGAACTATTCTTTAAACGCACATGGGGTGAATTATACAAAAAGTTATGTAGCATCTCCTGGCTGTAGTGAACATCATACGGGACTAGCAATTGATCTCGGTCTACGAAAGACAGAACATGATCTCATTGCGCCACGCTTCGAGGGACCAGAAGCCGAACTGTTTTTACAACATATGAAAGATTATGGATTTATTTTACGCTATCCTAAAAATAAGCAAAAAATTACAGGAATTGCTTATGAGCCTTGGCATTTTCGCTATGTAGGTACCCCTCATAGTCAAATCATCATGGACCACGGATGGACCTTAGAAGAGTATATTGAATTTTTAAAACATCAAATTGAGGCGGTCTCATGA UPDATED fmax with 2165 UPDATED accession with JF802084.2 UPDATED fmin with 1592 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterococcus faecium UPDATED NCBI_taxonomy_id with 1352 UPDATED NCBI_taxonomy_cvterm_id with 36779 UPDATED accession with AEP40501.1 UPDATED sequence with MHNFYLQLVNQQHPWKSFNHSPQLVQATYAEEKILIDSKVNHQFNQLLETLQLTDRIMIVDGHRTVAEQKHLWNYSLNAHGVNYTKSYVASPGCSEHHTGLAIDLGLRKTEHDLIAPRFEGPEAELFLQHMKDYGFILRYPKNKQKITGIAYEPWHFRYVGTPHSQIIMDHGWTLEEYIEFLKHQIEAVS UPDATED model_name with vanXY gene in vanN cluster UPDATED ARO_name with vanXY gene in vanN cluster " 2149 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B antibiotic target alteration; hygromycin B; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; model_name "UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B " 1009 UPDATE IND-1 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-1 is a beta-lactamase found in Chryseobacterium indologenes. UPDATED accession with AF099139.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 1008 UPDATE BEL-1 penam; monobactam; cephalosporin; antibiotic inactivation; BEL beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with BEL-1 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with DQ089809.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1007 UPDATE OKP-A-8 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-8 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051147.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 510 UPDATE CTX-M-9 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-9 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AF174129.1 " 1005 UPDATE Escherichia coli soxR with mutation conferring antibiotic resistance antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; model_sequences; ARO_category "UPDATED accession with U00096.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 512 UPDATE CTX-M-82 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-82 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with DQ256091.1 " 515 UPDATE mgtA antibiotic inactivation; methymycin; macrolide antibiotic; mgt macrolide glycotransferase; tylosin; azithromycin; erythromycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAGCGAAAAGAGTTGCACGAGACGTCTCGTCTCGCATACGGTCGTCGCATGACCACTCGCCCCGCGCACATCGCCATGTTCTCCATCGCCCTGCACGGCCACGTGAACCCCAGCCTGGAGGTCATCCGCGAGCTCGTCGCGCGGGGGCACCGGGTGACGTACGCGATCCCGCCGCTCCTCGCGGACAAGGTCGCCGAGGCGGGCGCCGAACCCAAGCTCTGGAACAGCACACTGCCCGGCCCCGACGCCGACCCGGAGGCCTGGGGGAGCACCCTCCTGGACAACGTGGAGCCCTTCCTCGCCGACGCGATCCAGTCGCTCCCGCAGCTCGCCCAGGCGTACGAGGGGGACGAGCCGGACCTGGTCCTGCACGACATCGCCTCCTACACCGCCCGCGTCCTGGGCCGCCGCTGGGAGGTGCCCGTGATCTCCCTGTCGCCCTGCATGGTCGCCTGGGAGGGGTACGAGCAGGAGGTCGGCGAGCCGATGTGGGAGGAGCCGCGGAAGACCGAGCGCGGGCAGGCGTACTACGCCCGCTTCCACGCCTGGCTGGAGGAGAACGGGATCACCGACCACCCCGACCCGTTCATCGGCCGCCCCGACCGCTCCCTGGTGCTGATCCCCAAGGCGCTCCAGCCCCACGCCGACCGGGTGGACGAGACGACGTACACCTTCGTCGGCGCCTGCCAGGGGGACCGCACCGCCGAGGGCGACTGGGCCCGTCCCGAGGGCGCGGAGAAGGTCGTCCTGGTCTCGCTCGGTTCGGCCTTCACCAAGCAGCCCGCGTTCTACCGGGAGTGCGTCCGGGCCTTCGGTGAGCTGCCCGGCTGGCACACCGTGCTCCAGGTCGGCCGGCACGTAGACCCGGCCGAGCTGGGCGACGTACCGGACAACGTGGAAGTCCGCACGTGGGTACCGCAGTTGGCGATCCTCCAGCAGGCCGACCTGTTCGTCACCCACGCGGGCGCGGGCGGCAGCCAGGAGGGTCTGGCCACCGCCACGCCGATGATCGCCGTACCGCAGGCCGCGGACCAGTTCGGCAACGCCGACATGCTCCAGGGCCTCGGCGTCGCCCGCACCCTCCCGACCGAGGAGGCCACCGCGAAGGCGCTGCGCACCGCCGCCCTCGCCCTGGTCGACGACCCGGAGGTGGCGGCGCGCCTGAAGGAGATCCAGGCGCGGATGGCCCAGGAGGGCGGCACCCGCCGGGCCGCCGACCTCATCGAGGCCGAACTGGCCGCCGCGCGCGGCTGA UPDATED fmax with 1257 UPDATED accession with DQ185434.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Streptomyces lividans UPDATED NCBI_taxonomy_id with 1916 UPDATED NCBI_taxonomy_cvterm_id with 39569 UPDATED accession with ABA28305.2 UPDATED sequence with MKRKELHETSRLAYGRRMTTRPAHIAMFSIALHGHVNPSLEVIRELVARGHRVTYAIPPLLADKVAEAGAEPKLWNSTLPGPDADPEAWGSTLLDNVEPFLADAIQSLPQLAQAYEGDEPDLVLHDIASYTARVLGRRWEVPVISLSPCMVAWEGYEQEVGEPMWEEPRKTERGQAYYARFHAWLEENGITDHPDPFIGRPDRSLVLIPKALQPHADRVDETTYTFVGACQGDRTAEGDWARPEGAEKVVLVSLGSAFTKQPAFYRECVRAFGELPGWHTVLQVGRHVDPAELGDVPDNVEVRTWVPQLAILQQADLFVTHAGAGGSQEGLATATPMIAVPQAADQFGNADMLQGLGVARTLPTEEATAKALRTAALALVDDPEVAARLKEIQARMAQEGGTRRAADLIEAELAAARG " 514 UPDATE LEN-10 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with LEN-10 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1001 UPDATE Staphylococcus aureus mprF with mutation conferring resistance to daptomycin peptide antibiotic; antibiotic target alteration; daptomycin; daptomycin resistant mprF; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations that occur within Staphylococcus aureus mprF gene resulting in resistance to daptomycin. UPDATED accession with HM140977.1 UPDATED accession with ADJ67256.1 UPDATED model_name with Staphylococcus aureus mprF with mutation conferring resistance to daptomycin " 1000 UPDATE AAC(6')-Ib-Hangzhou AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ib-Hangzhou is an aminoglycoside acetyltransferase in A. baumannii. UPDATED accession with FJ503047.1 " 621 UPDATE ErmF antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with M17124.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 627 UPDATE Escherichia coli rpoB mutants conferring resistance to rifampicin rifampin; rifapentine; rifabutin; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); antibiotic target replacement; antibiotic target alteration; rifaximin; rifamycin antibiotic; ARO_description "UPDATED ARO_description with Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin. " 1222 UPDATE FosA fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; model_name "UPDATED model_name with FosA " 1221 UPDATE OXA-231 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-231 is a beta-lactamase found in A. baumannii. UPDATED partial with 0 UPDATED sequence with ATGAAAAAATTTATACTTCCTATTCTCAGCATTTCTACTCTACTTTCTGTCAGTGCATGCTCATCTATTCAAACTAAATTTGAAGACACTTTTCATACTTCTAATCAGCAACATGAAAAAGCCATTAAAAGCTATTTTGATGAAGCTCAAACACAGGGTGTAATCATTATTAAAAAGGGAAAAAATATTAGTACCTATGGTAATAACCTGACACGAGCACATACAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCCTTAATTGGACTAGAAAATCATAAAGCTACAACAACTGAGATTTTCAAATGGGACGGTAAAAAGAGATCTTATCCCATGTGGGAAAAAGATATGACTTTAGGTGATGCCATGGCACTTTCAGCAGTTCCTGTATATCAAGAACTTGCAAGACGGACTGGCTTAGACCTAATGCAAAAAGAAGTTAAACGGGTTGGTTTTGGTAATATGAACATTGGAACACAAGTTGATAACTTCTGGTTGGTTGGCCCCCTCAAGATTACACCAATACAAGAGGTTAATTTTGCCGATGATTTTGCAAATAATCGATTACCCTTTAAATTAGAGACTCAAGAAGAAGTTAAAAAAATGCTTCTGATTAAAGAATTCAATGGTAGTAAAATTTATGCAAAAAGCGGCTGGGGAATGGCTGTAACCCCTCAAGTAGGTTGGTTAACAGGTTGGGTAGAAAAATCTAATGGAGAAAAAGTTGCCTTTTCTCTAAACATAGAAATGAAGCAAGGAATGCCTGGTTCTATTCGTAATGAAATTACTTATAAATCATTAGAGAATTTAGGGATTATATAA UPDATED fmax with 1021 UPDATED accession with JQ326200.2 UPDATED fmin with 193 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with AFG29918.1 UPDATED sequence with MKKFILPILSISTLLSVSACSSIQTKFEDTFHTSNQQHEKAIKSYFDEAQTQGVIIIKKGKNISTYGNNLTRAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEKDMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMNIGTQVDNFWLVGPLKITPIQEVNFADDFANNRLPFKLETQEEVKKMLLIKEFNGSKIYAKSGWGMAVTPQVGWLTGWVEKSNGEKVAFSLNIEMKQGMPGSIRNEITYKSLENLGII UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1220 UPDATE OCH-5 penam; antibiotic inactivation; penem; cephalosporin; cephamycin; monobactam; OCH beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OCH-5 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. UPDATED accession with AJ295343.1 UPDATED NCBI_taxonomy_name with Brucella anthropi UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. " 5663 UPDATE SPU-1 carbapenem; antibiotic inactivation; SPU beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5662 UPDATE SPS-1 SPS beta-lactamase; carbapenem; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5661 UPDATE SPR-1 carbapenem; SPR beta-lactamase; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5666 UPDATE STA-1 STA beta-lactamase; carbapenem; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5664 UPDATE SRT-3 antibiotic inactivation; cephalosporin; SRT beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5669 UPDATE TEM-99 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5668 UPDATE TEM-98 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4342 UPDATE ADC-86 antibiotic inactivation; cephalosporin; ADC beta-lactamases pending classification for carbapenemase activity; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4341 UPDATE ADC-85 antibiotic inactivation; cephalosporin; ADC beta-lactamases pending classification for carbapenemase activity; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 2886 UPDATE Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics penam; cephamycin; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. " 2884 UPDATE RSA-1 carbapenem; antibiotic inactivation; cephalosporin; RSA beta-lactamase; ARO_category "UPDATED category_aro_description with A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity. " 2885 UPDATE RSA-2 carbapenem; antibiotic inactivation; cephalosporin; RSA beta-lactamase; ARO_category "UPDATED category_aro_description with A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity. " 1072 UPDATE OXA-37 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-37 is a beta-lactamase found in A. baumannii. UPDATED accession with AY007784.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2888 UPDATE HERA-1 penam; HERA beta-lactamase; antibiotic inactivation; ARO_description; ARO_category "UPDATED ARO_description with A class A beta-lactamase with penicillinase activity described in Atlantibacter (Escherichia) hermannii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2889 UPDATE TRU-1 penam; antibiotic inactivation; cephalosporin; TRU beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi). " 2 UPDATE CblA-1 antibiotic inactivation; CblA beta-lactamase; cephaloridine; cephalosporin; model_sequences "UPDATED accession with GQ343019.1 " 3879 UPDATE APH(3')-XV antibiotic inactivation; APH(3'); aminoglycoside antibiotic; G418; neomycin; ARO_category "UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 4395 UPDATE BlaB-33 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1286 UPDATE SHV-34 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY036620.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1714 UPDATE ErmW antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; model_sequences "UPDATED accession with D14532.1 " 1043 UPDATE SHV-76 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCGCCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGTGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGAAGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATCGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 891 UPDATED accession with AM176551.2 UPDATED fmin with 30 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47131.2 UPDATED sequence with MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVEDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 11 UPDATE Erm(34) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with AY234334.1 UPDATED NCBI_taxonomy_name with Alkalihalobacillus clausii UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 10 UPDATE CARB-5 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-5 is a beta-lactamase found in Acinetobacter calcoaceticus. UPDATED accession with AF135373.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 13 UPDATE LRA-12 penam; antibiotic inactivation; subclass B3 LRA beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LRA-12 is a beta-lactamase isolated from soil samples in Alaska. UPDATED accession with EU408351.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 12 UPDATE TEM-126 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY628199.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 15 UPDATE TEM-59 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF062386.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 14 UPDATE TEM-72 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF157553.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5719 UPDATE VIM-70 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5718 UPDATE VIM-69 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5717 UPDATE VIM-68 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5716 UPDATE VIM-67 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5715 UPDATE VIM-66 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5714 UPDATE VIM-65 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5713 UPDATE VIM-64 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5712 UPDATE VIM-63 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5711 UPDATE VIM-62 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5710 UPDATE VIM-61 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1924 UPDATE vanM glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; model_sequences; ARO_category "UPDATED accession with FJ349556.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 3904 UPDATE CMY-165 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_065862.1 " 3905 UPDATE CMY-166 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_065863.1 " 3906 UPDATE CMY-149 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_054682.1 " 3907 UPDATE CMY-139 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_048807.1 " 3900 UPDATE CMY-162 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_060523.1 " 3901 UPDATE CMY-140 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_050943.1 " 3902 UPDATE CMY-164 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_065422.1 " 3903 UPDATE CMY-161 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_057479.1 " 1927 UPDATE SHV-29 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF301532.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3908 UPDATE CMY-148 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_054681.1 " 3909 UPDATE CMY-163 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_060564.1 " 4763 UPDATE MIR-18 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_category "UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 4765 UPDATE MIR-20 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_category "UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 4764 UPDATE MIR-19 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_category "UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 4767 UPDATE MIR-22 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_category "UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 4766 UPDATE MIR-21 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_category "UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 4768 UPDATE MIR-7 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_category "UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 4167 UPDATE ACT-77 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4166 UPDATE ACT-76 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4165 UPDATE ACT-75 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4164 UPDATE ACT-74 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4163 UPDATE ACT-73 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4162 UPDATE ACT-72 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4161 UPDATE ACT-70 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4160 UPDATE ACT-69 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 599 UPDATE OKP-A-3 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-3 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051140.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 3604 UPDATE GOB-3 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4169 UPDATE ACT-79 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4168 UPDATE ACT-78 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1073 UPDATE OKP-B-19 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-19 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAGGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCATGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCTGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACACCGCCGGCAATCTGCTGTTGAAGATCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGCTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTTGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGTGATACCCCGGCGACCATGGTCGAGCGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 885 UPDATED accession with AM850921.2 UPDATED fmin with 24 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12359.2 UPDATED sequence with MRYVRLCLISLIAALPLAVFASPQPLEQIKISEGQLAGRVGYVEMDLASGRMLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNTAGNLLLKIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTPATMVERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 201 UPDATE OCH-3 penam; antibiotic inactivation; penem; cephalosporin; cephamycin; monobactam; OCH beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OCH-3 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. UPDATED accession with AJ295341.1 UPDATED NCBI_taxonomy_name with Brucella anthropi UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. " 200 UPDATE LEN-14 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences; ARO_category "UPDATED accession with AY265889.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 203 UPDATE OXY-2-8 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-8 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AY055205.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 202 UPDATE SHV-101 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU155018.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 205 UPDATE APH(4)-Ia antibiotic inactivation; hygromycin B; aminoglycoside antibiotic; APH(4); plazomicin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(4)-Ia is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. UPDATED accession with V01499.1 UPDATED category_aro_description with Phosphorylation of hygromycin on the hydroxyl group at position 4. " 204 UPDATE VIM-43 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP096412.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 207 UPDATE GES-12 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-12 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with FN554543.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 206 UPDATE FomA fosfomycin; antibiotic inactivation; Fom phosphotransferase family; model_sequences "UPDATED accession with AB016934.1 " 209 UPDATE AAC(3)-Ib/AAC(6')-Ib'' antibiotic inactivation; AAC(3); AAC(6'); kanamycin A; gentamicin C; aminoglycoside antibiotic; tobramycin; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-Ib/AAC(6')-Ib'' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with AF355189.1 " 208 UPDATE CMY-105 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KJ207205.1 " 2745 UPDATE AcrAB-TolC penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; model_description; ARO_category; model_name "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED model_name with AcrAB-TolC " 830 UPDATE SHV-157 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121124.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 642 UPDATE aadA25 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Streptomycin/spectinomycin resistance gene found in Pasteurella multocida isolated from bovine respiratory tract. UPDATED accession with CP003022.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1573 UPDATE SHV-110 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ877615.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 831 UPDATE OKP-B-13 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-13 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY825330.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1572 UPDATE OXA-205 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JF800667.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 836 UPDATE TEM-68 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ239002.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1571 UPDATE vanSE glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSE, is a vanS variant found in the vanE gene cluster. UPDATED accession with FJ872411.1 UPDATED model_name with vanS gene in vanE cluster UPDATED ARO_name with vanS gene in vanE cluster " 837 UPDATE vatH dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with vatH is a plasmid-mediated acetyltransferase found in Enterococcus faecium. UPDATED partial with 0 UPDATED sequence with ATGGCAGAAAAATTAAAAGGACCCAACTCAAATGAAATGTATCCGATTGCCGGAAATAAAAGTGTTCAATTTGTTAAACCGTCATTAACAAGGCCCAATATTATAGTTGGTGAGTTCACTTATTATGATAGCAAGAACGGAGAGCTTTTTGAGGATCAAGTTCTGTATCATTATGAAATTATAGGGGATCGACTGATCATCGGGAAATTTTGTTCAATCGGTCCTGGAGTCACTTTTATTATGAATGGAGCTAATCATCGCATGGATGGCTCCACTTATCCATTTAATATCTTTGGGCATGGGTGGGAAAAGCATACACCTACACTAGATATGCTGCCTTTAAAGGGGGATACTATTGTTGGTAATGACGTATGGATTGGACTAGATGCTACAATTATGCCAGGCGTAAAAATAGGAGACGGCGCGATTATTGCAGCCAAATCTGTAGTAACAAAAGACGTTGACCCCTCCACAATTGTTGGTGGTAATCCTGCAAAACAAATAAAGAAACGATTTTCGGAGTCAAAAATTCAAGAACTATTAAAGATAAAATGGTGGGATTTTGAAGACCAGGTTATTAGCGATAATATTGATGCTATTCTAAGTTTGGATGTTGAAGCGCTTAATAATATTTCTAAAGAAAATGATTAG UPDATED fmax with 3687 UPDATED accession with GQ205627.2 UPDATED fmin with 3036 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterococcus faecium UPDATED NCBI_taxonomy_id with 1352 UPDATED NCBI_taxonomy_cvterm_id with 36779 UPDATED accession with ACX92987.1 UPDATED sequence with MAEKLKGPNSNEMYPIAGNKSVQFVKPSLTRPNIIVGEFTYYDSKNGELFEDQVLYHYEIIGDRLIIGKFCSIGPGVTFIMNGANHRMDGSTYPFNIFGHGWEKHTPTLDMLPLKGDTIVGNDVWIGLDATIMPGVKIGDGAIIAAKSVVTKDVDPSTIVGGNPAKQIKKRFSESKIQELLKIKWWDFEDQVISDNIDAILSLDVEALNNISKEND UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 2245 UPDATE vanKI glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanK; ARO_description; ARO_category; model_name; ARO_name "UPDATED ARO_description with Also known as vanKI, is a peptidoglycan bridge formation protein also known as FemAB that is part of the vanI glycopeptide resistance gene cluster. UPDATED category_aro_description with VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance. UPDATED model_name with vanK gene in vanI cluster UPDATED ARO_name with vanK gene in vanI cluster " 1570 UPDATE OprA antibiotic efflux; tobramycin; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; meropenem; macrolide antibiotic; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; arbekacin; ciprofloxacin; tetracycline antibiotic; gentamicin C; amikacin; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; model_sequences; model_name "UPDATED accession with AB639410.1 UPDATED model_name with OprA " 834 UPDATE FosA3 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; model_sequences "UPDATED accession with JF411006.1 " 998 UPDATE SHV-134 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM559945.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2231 UPDATE CPS-1 carbapenem; antibiotic inactivation; CPS beta-lactamase; model_sequences "UPDATED accession with KP109675.1 UPDATED accession with AJP77054.1 " 2230 UPDATE PEDO-3 carbapenem; antibiotic inactivation; subclass B1 PEDO beta-lactamase; model_sequences "UPDATED accession with KP109679.1 UPDATED accession with AJP77076.1 " 2233 UPDATE MSI-1 carbapenem; antibiotic inactivation; MSI beta-lactamase; model_sequences "UPDATED accession with KP109676.1 UPDATED accession with AJP77057.1 " 2232 UPDATE ESP-1 carbapenem; antibiotic inactivation; ESP beta-lactamase; model_sequences "UPDATED accession with KP109681.1 UPDATED accession with AJP77085.1 " 2235 UPDATE SPG-1 carbapenem; SPG beta-lactamase; antibiotic inactivation; model_sequences "UPDATED accession with KP109680.1 UPDATED accession with AJP77080.1 " 2234 UPDATE MSI-OXA MSI-OXA family beta-lactamase; carbapenem; antibiotic inactivation; model_sequences "UPDATED accession with KP109676.1 UPDATED accession with AJP77058.1 " 1576 UPDATE OXA-17 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAAAACATTTGCCGCATATGTAATTATCGCGTGTCTTTCGAGTACGGCATTAGCTGGTTCAATTACAGAAAATACGTCTTGGAACAAAGAGTTCTCTGCCGAAGCCGTCAATGGTGTCTTCGTGCTTTGTAAAAGTAGCAGTAAATCCTGCGCTACCAATGACTTAGCTCGTGCATCAAAGGAATATCTTCCAGCATCAACATTTAAGATCCCCAGCGCAATTATCGGCCTAGAAACTGGTGTCATAAAGAATGAGCATCAGGTTTTCAAATGGGACGGAAAGCCAAGAGCCATGAAGCAATGGGAAAGAGACTTGACCTTAAGAGGGGCAATACAAGTTTCAGCTGTTCCCGTATTTCAACAAATCGCCAGAGAAGTTGGCGAAGTAAGAATGCAGAAATACCTTAAAAAATTTTCCTATGGCAACCAGAATATCAGTGGTGGCATTGACAAATTCTGGTTGGAAGGCCAGCTTAGAATTTCCGCAGTTAATCAAGTGGAGTTTCTAGAGTCTCTATATTTAAATAAATTGTCAGCATCTAAAGAAAACCAGCTAATAGTAAAAGAGGCTTTGGTAACGGAGGCGGCACCTGAATATCTAGTGCATTCAAAAACTGGTTTTTCTGGTGTGGGAACTGAGTCAAATCCTGGTGTCGCATGGTGGGTTGGGTGGGTTGAGAAGGAGACAGAGGTTTACTTTTTCGCCTTTAACATGGATATAGACAACGAAAGTAAGTTGCCGCTAAGAAAATCCATTCCCACCAAAATCATGGAAAGTGAGGGCATCATTGGTGGCTAA UPDATED fmax with 3517 UPDATED accession with DQ902344.1 UPDATED fmin with 2716 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with ABI63579.1 UPDATED sequence with MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3575 UPDATE CME-1 penam; antibiotic inactivation; CME beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1575 UPDATE OXA-91 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-91 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ519086.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3574 UPDATE CKO-1 CKO beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1574 UPDATE Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid isoniazid; antibiotic target alteration; isoniazid resistant inhA; model_sequences; ARO_category "UPDATED accession with AL123456.1 UPDATED category_aro_description with Genes with mutations in inhA which confer resistance to isoniazid class antibiotics. " 1711 UPDATE AQU-1 antibiotic inactivation; AQU beta-lactamase; cephalosporin; ARO_description; model_sequences "UPDATED ARO_description with AQU-1 is a chromosomal class C beta-lactamase found in clinical Aeromonas dhakensis isolates. UPDATED accession with AB765395.1 " 3577 UPDATE CMY-132 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description "UPDATED ARO_description with From Lahey's list of beta-lactamases, no additional information available. " 2185 UPDATE glycopeptide resistance gene cluster VanM glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Homologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX. " 3498 UPDATE OXA-414 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3499 UPDATE OXA-416 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3496 UPDATE OXA-412 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3497 UPDATE OXA-413 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3494 UPDATE OXA-409 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3495 UPDATE OXA-411 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3492 UPDATE OXA-407 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3493 UPDATE OXA-408 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3490 UPDATE OXA-405 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3491 UPDATE OXA-406 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3658 UPDATE NDM-16 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with New Delhi class B metallo-beta-lactamase-16 variant of NDM-1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3659 UPDATE NDM-18 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase and NDM-1 variant. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4607 UPDATE FOX-17 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_category "UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 3656 UPDATE Burkholderia dolosa gyrA conferring resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrA; ciprofloxacin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGGATCAATTCGCCAAAGAGACCCTGCCCACCTCCCTCGAGGAGGAAATGCGCCGTTCGTATCTCGATTACGCGATGAGCGTGATCGTCGGACGTGCCCTTCCGGATGTCCGCGATGGCCTGAAGCCCGTGCACCGGCGCGTACTGTTCGCGATGCACGAACTGAACAACGACTGGAACCGCGCGTACAAGAAATCGGCGCGTATCGTCGGCGACGTGATCGGTAAGTACCACCCGCACGGCGACACGGCGGTCTACGACACGATCGTGCGGATGGCGCAGGACTTCTCGCTGCGCTACATGCTGATCGACGGGCAGGGCAACTTCGGCTCGATCGACGGCGACAATGCGGCGGCGATGCGGTACACCGAAATTCGCATGGCGAAGATCGGGCACGAGCTGCTCGCCGACATCGACAAGGAAACGGTCGATTTCGAGCCGAACTACGACGGCAACGAAACGCAGCCGTCGGTCCTGCCGTCGCGGATCCCGAACCTGCTGATCAACGGCTCGTCGGGCATCGCCGTCGGCATGGCGACCAACATTCCGCCGCACAACCTGAACGAAGTCGTCGACGCGTGCCAGCACCTGCTGAGCAACCCCGACGCGACGGTCGACGAACTGATCGAGATCATCCCGGCGCCGGATTTCCCGACGGCCGGCATCATCTACGGCGTCGCCGGCGTGCGCGACGGCTACCGCACCGGCCGCGGCCGCGTCGTGATGCGCGCGGCCACGCACTTCGAGGAGATCGACCGCGGCCAGCGGATGGCGATCATCGTCGACGAGCTGCCGTACCAGGTCAACAAGCGCTCGCTGCTCGAGCGGATCGCCGAGCTCGTCAACGAGAAGAAGCTCGAAGGCATTTCCGATATCCGCGACGAATCCGACAAGAGCGGCATGCGGGTCGTGATCGAGCTCAAGCGCGGCGAAGTGCCGGAAGTGGTGCTGAACAACCTGTACAAGGCGACGCAGCTGCAGGACACGTTCGGCATGAACATGGTCGCGCTCGTCGACGGCCAGCCGAAGCTGCTGAACCTGAAGGAAATCCTGCAGTGCTTCCTGTCGCACCGGCGCGAAGTGCTGACGCGCCGCACGATCTACGAACTGCGCAAGGCGCGCGAGCGCGGCCACGTGCTCGAAGGTCTCGCGGTCGCGCTCGCGAACATCGACGAGTTCATCGCGATCATCAAGGCCGCGCCGACGCCGCCGATCGCGAAGCAGGAGCTGATGACGAAGTCGTGGGATTCGTCGCTCGTACGCGAGATGCTGACGCGCGCCGAATCCGAGAACGCGGCGGCGGGCGGCCGTGCCGCGTACCGTCCGGAAGGGCTGAATCCGGCGTACGGGATGCAGGCCGACGGGCTGTACAGGTTGTCCGACACGCAGGCGCAGGAAATCCTGCAGATGCGTCTGCAGCGCCTGACCGGCCTCGAGCAGGACAAGATCATCGGCGAGTATCGCGAAGTGATGGCGCAGATCGCCGATCTGCTCGACATCCTCGCGCGCCCGGAGCGCATCACGACGATGATCGGCGACGAGCTGACGACGGTGAAGGCCGAATTCGGCGATGCGCGCCGCTCGCGGATCGAGCTGAACGCGACCGAACTGAATACCGAAGACCTGATCACGCCGCAGGACATGGTCGTCACGATGTCGCATGCCGGCTACGTGAAGTCGCAGCCGCTGTCGGAGTACCGCGCGCAGAAGCGCGGCGGCCGCGGCAAGCAGGCGACGCAGATGAAGGAAGACGACTGGATCGAGACGCTCTTCATCGCGAATACGCACGACTACATGCTGTGCTTCTCGAACCGCGGTCGCGTGTACTGGATCAAGGTCTACGAGGTGCCGCAAGGTTCGCGCAACTCGCGCGGCCGTCCGATCGTCAACATGTTCCCGCTGCAGGAAGGCGAGAAGATCAACGTCGTGCTGCCGGTGAAGGAATTCTCGGCCGACAAGTTCGTGTTCATGGCGACGTCGCTCGGCACGGTCAAGAAGACGCCGCTCGAAGCGTTCAGCCGTCCGATGAAGAAGGGCATCATCGCGGTCGGCCTCGACGAGGGCGACTATCTGATCGGCGCGTCGATCACCGACGGCGCGCACGACGTGATGCTGTTCTCCGATTCGGGCAAGGCCGTGCGCTTCGACGAGAACGACGTGCGTCCGATGGGCCGCGAAGCGCGCGGCGTGCGCGGCATGCAGCTCGAGGACGGGCAGCAGGTCATCGCGCTGCTGGTCGCGGGCAGCGAGGAGCAGTCCGTGCTCACCGCAACCGAGAACGGCTTCGGCAAGCGTACGCCGATCACCGAGTACACGCGTCACGGCCGCGGCACGAAGGGTATGATCGCGATCCAGACCTCCGAGCGTAACGGCAAGGTCGTCGCTGCGACGCTCGTCGATCCGGAAGATCAGATCATGCTGATCACGACGGCCGGCGTGTTGATTCGCACGCGCGTTTCCGAGATCCGCGAGATGGGACGGGCGACGCAAGGTGTTACACTCATCAGTCTCGATGAGGGTACGAAGCTTTCGGGTCTGCAGCAGATTGCCGAGGCCGAAGAGGGCGATGGCGAAGCCGACGAGGCGTCGGACGGCGAAGCCTGA UPDATED fmax with 2301346 UPDATED accession with CP009795.1 UPDATED fmin with 2298742 UPDATED strand with - UPDATED NCBI_taxonomy_name with Burkholderia dolosa AU0158 UPDATED NCBI_taxonomy_id with 350701 UPDATED NCBI_taxonomy_cvterm_id with 42997 UPDATED accession with AJY14066.1 UPDATED sequence with MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFEPNYDGNETQPSVLPSRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLSNPDATVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRVVMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMTKSWDSSLVREMLTRAESENAAAGGRAAYRPEGLNPAYGMQADGLYRLSDTQAQEILQMRLQRLTGLEQDKIIGEYREVMAQIADLLDILARPERITTMIGDELTTVKAEFGDARRSRIELNATELNTEDLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYMLCFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQEGEKINVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDSGKAVRFDENDVRPMGREARGVRGMQLEDGQQVIALLVAGSEEQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVDPEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEEGDGEADEASDGEA " 3657 UPDATE NDM-15 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with New Delhi metallo-beta-lactamase-15 variant of NDM-1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2099 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A kanamycin A; antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_name "UPDATED ARO_description with Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A " 3652 UPDATE CMY-136 antibiotic inactivation; cefotaxime; cephalosporin; cephamycin; cefuroxime; CMY beta-lactamase; ceftolozane; ARO_category "UPDATED category_aro_description with A fifth generation cephalosporin antibiotic. " 3653 UPDATE SCO-1 penam; cefalotin; antibiotic inactivation; penicillin; penem; piperacillin-tazobactam; cephalosporin; cefotaxime; ceftazidime; cefepime; SCO beta-lactamase; ticarcillin; ticarcillin-clavulanic acid; amoxicillin; cefuroxime; clavulanic acid; piperacillin; tazobactam; amoxicillin-clavulanic acid; ARO_description; ARO_category "UPDATED ARO_description with Narrow-spectrum beta-lactamase isolated from several Acinetobacter spp. isolates from Argentina, as well as E. Coli. Hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2526 UPDATE vgbC virginiamycin S2; pristinamycin IB; quinupristin; pristinamycin IC; patricin B; patricin A; ostreogrycin B3; vernamycin C; pristinamycin IA; antibiotic inactivation; streptogramin antibiotic; streptogramin vgb lyase; ARO_category; model_name "UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. UPDATED model_name with vgbC " 2520 UPDATE CatU antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_category "UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 2523 UPDATE VatI dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 4602 UPDATE FOX-12 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_category "UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 2529 UPDATE cpaA antibiotic inactivation; capreomycin; aminoglycoside antibiotic; cpa acetyltransferase; ARO_category "UPDATED category_aro_description with Acetyltransferases of the cpa family confer resistance to capreomycin, an aminoglycoside antibiotic. " 4603 UPDATE FOX-13 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_category "UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 4600 UPDATE EVM-1 carbapenem; antibiotic inactivation; EVM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 2666 UPDATE Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan isoniazid; antibiotic target alteration; triclosan; disinfecting agents and antiseptics; antibiotic resistant fabI; ARO_description; ARO_category; model_name "UPDATED ARO_description with fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED model_name with Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan " 4601 UPDATE FIA-1 carbapenem; antibiotic inactivation; FIA beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 598 UPDATE dfrA16 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA16 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. UPDATED partial with 0 UPDATED sequence with GTGAAGTTATCACTAATGGCTGCCAAGTCGAAGAACGGTATTATCGGTAATGGACCAGATATTCCATGGAGCGCCAAAGGCGAGCAACTTCTATTTAAGGCAATTACATATAATCAATGGCTTTTAGTTGGACGCAAAACTTTTGAGTCAATGGGCGCTCTCCCAAATCGAAAGTATGCAGTTGTAACTCGCTCTAATTTTTCTACGAATGATGAGGGTGTAATGGTTTTCTCCTCAATTCAGGATGCCTTAATAAATTTAGAGGAAATCACGGATCATGTTATCGTTTCTGGTGGTGGTGAAATATACAAAAGCTTGATTTCCAAAGTAGATACTTTGCATATTTCAACAGTCGACATCGAGCGAGATGGAGACATAGTTTTTCCTGAAATCCCAGATACATTCAAGTTGGTATTTGAGCAAGATTTCGAGTCTAACATTAACTATTGTTATCAAATCTGGCAAAAGAGTTAA UPDATED fmax with 1825 UPDATED accession with AF174129.3 UPDATED fmin with 1351 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAK60186.1 UPDATED sequence with MKLSLMAAKSKNGIIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSNFSTNDEGVMVFSSIQDALINLEEITDHVIVSGGGEIYKSLISKVDTLHISTVDIERDGDIVFPEIPDTFKLVFEQDFESNINYCYQIWQKS " 5065 UPDATE OXA-756 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5064 UPDATE OXA-755 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5067 UPDATE OXA-758 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5066 UPDATE OXA-757 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5061 UPDATE OXA-752 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5060 UPDATE OXA-751 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5063 UPDATE OXA-754 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5062 UPDATE OXA-753 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4880 UPDATE OXA-551 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2704 UPDATE MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; trimethoprim; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; ciprofloxacin; fluoroquinolone antibiotic; phenicol antibiotic; chloramphenicol; ARO_description; model_description "UPDATED ARO_description with The MexEF–OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin. UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 4882 UPDATE OXA-553 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5069 UPDATE OXA-760 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4885 UPDATE OXA-556 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4886 UPDATE OXA-557 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4887 UPDATE OXA-558 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1070 UPDATE sul1 sulfadiazine; sulfadoxine; sulfacetamide; sulfadimidine; mafenide; sulfamethoxazole; sulfisoxazole; sulfonamide resistant sul; antibiotic target replacement; sulfamethizole; sulfasalazine; sulfonamide antibiotic; model_sequences "UPDATED accession with JF969163.1 " 4090 UPDATE KPC-26 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-26 [Klebsiella pneumoniae] Accession: WP_068981634.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4719 UPDATE KPC-21 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4408 UPDATE CAR-1 carbapenem; antibiotic inactivation; CAR beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4409 UPDATE CARB-11 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4404 UPDATE BlaB-8 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4405 UPDATE BlaB-9 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1827 UPDATE SHV-5 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with X55640.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4400 UPDATE BlaB-39 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4401 UPDATE BlaB-5 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4402 UPDATE BlaB-6 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4403 UPDATE BlaB-7 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 928 UPDATE carA pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with carA is an ABC-F subfamily protein involved in macrolide resistance. It is found in Streptomyces thermotolerans. UPDATED accession with M80346.1 " 2146 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin antibiotic target alteration; streptomycin; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 5' domain of helix 18, in the rrnB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin " 2145 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline tetracycline antibiotic; antibiotic target alteration; 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline " 2144 UPDATE Mycobacterium tuberculosis variant bovis embB with mutation conferring resistance to ethambutol antibiotic target alteration; polyamine antibiotic; ethambutol; ethambutol resistant embB; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations that occur within Mycobacterium tuberculosis variant bovis embB gene resulting in resistance to ethambutol. UPDATED accession with BX248333.1 UPDATED model_name with Mycobacterium tuberculosis variant bovis embB with mutation conferring resistance to ethambutol " 4978 UPDATE OXA-658 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4979 UPDATE OXA-659 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2141 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; ARO_description; model_name "UPDATED ARO_description with Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to neomycin. UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin " 2140 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin antibiotic target alteration; streptomycin; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 5' domain of helix 18, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin " 4974 UPDATE OXA-654 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 921 UPDATE OKP-A-11 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-11 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGCATTCGCCAGCCCTCCGCCGCTCGAGCAAGTTACACGCAGCGAAAGTCAGCTGGCGGGCCGCGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGAGACGAACAGCTGGATCGGCGGATCCGCTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTTGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAGCTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCAGCCAGCATGGCCGCCACCCTGCGCAAGCTGCTAACCAGCCACGCGCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCAGGTGGCCGGTCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGCGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGAACGGCAAAGCGGAGCGCATCGTGGTGATCTATCTGCGGGATACGCCGGCGACCATGGCCGAGCGTAACCAGCAGATCGCCAGAATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 880 UPDATED accession with AM850915.2 UPDATED fmin with 19 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12353.2 UPDATED sequence with MRYVRLCLISLIAALPLAAFASPPPLEQVTRSESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIRYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMAATLRKLLTSHALSARSQQQLLQWMVDDQVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPNGKAERIVVIYLRDTPATMAERNQQIARIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4976 UPDATE OXA-656 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4977 UPDATE OXA-657 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4970 UPDATE OXA-645 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4971 UPDATE OXA-650 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4972 UPDATE OXA-651 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2148 UPDATE Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name; ARO_name "UPDATED ARO_description with Point mutation in Ureaplasma urealyticum resulting in fluoroquinolone resistance. UPDATED model_name with Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones UPDATED ARO_name with Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones " 1920 UPDATE vanSF glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSF, is a vanS variant found in the vanF gene cluster. UPDATED accession with AF155139.1 UPDATED model_name with vanS gene in vanF cluster UPDATED ARO_name with vanS gene in vanF cluster " 1922 UPDATE marA penem; tetracycline antibiotic; antibiotic efflux; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; reduced permeability to antibiotic; carbapenem; cephalosporin; cefalotin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; tigecycline; glycylcycline; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1923 UPDATE APH(3'')-Ia antibiotic inactivation; APH(3''); streptomycin; aminoglycoside antibiotic; plazomicin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. UPDATED accession with X53527.1 UPDATED category_aro_description with Phosphorylation of streptomycin on the hydroxyl group at position 3''. " 3272 UPDATE PNGM-1 carbapenem; penam; cephalosporin; PNGM beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1925 UPDATE MexB sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; nalidixic acid; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; trimethoprim; azithromycin; chloramphenicol; model_sequences; ARO_category "UPDATED accession with L11616.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3270 UPDATE dfrA18 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with A trimethoprim-resistant dihydrofolate reductase identified from Vibrio cholerae. " 3271 UPDATE ICR-Mo peptide antibiotic; antibiotic target alteration; colistin B; intrinsic colistin resistant phosphoethanolamine transferase; colistin A; ARO_description "UPDATED ARO_description with A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella osloensis. ICR-Mo represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. " 1928 UPDATE OXA-50 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; ampicillin; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY306130.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1929 UPDATE ACT-24 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KJ207207.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 496 UPDATE KPC-16 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC465199.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3278 UPDATE Acinetobacter baumannii AbaQ efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; major facilitator superfamily (MFS) antibiotic efflux pump; antibiotic efflux; ARO_description "UPDATED ARO_description with AbaQ is an MFS transporter mainly involved in the extrusion of quinolone-type drugs in A. baumannii. " 3474 UPDATE OXA-340 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 833 UPDATE CfxA5 antibiotic inactivation; cephamycin; CfxA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CfxA5 beta-lactamase is a class A beta-lactamase found in Bacteroides distasonis. UPDATED accession with AY769934.1 UPDATED category_aro_description with CfxA beta-lactamases are class A beta-lactamases. " 3476 UPDATE OXA-342 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3477 UPDATE OXA-343 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3470 UPDATE OXA-308 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Acinetobacter gerneri DSM 14967 = CIP 107464 = MTCC 9824 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3471 UPDATE OXA-336 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3472 UPDATE OXA-337 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3473 UPDATE OXA-339 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 490 UPDATE TEM-188 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN211012.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 838 UPDATE CTX-M-102 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-102 is a beta-lactamase found in Escherichia coli. UPDATED accession with HQ398215.1 " 839 UPDATE CMY-44 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-44 is a beta-lactamase found in Escherichia coli. UPDATED accession with FJ437066.1 " 3478 UPDATE OXA-344 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3479 UPDATE OXA-345 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 491 UPDATE PER-2 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with PER-2 is a beta-lactamase found in Salmonella typhimurium. UPDATED accession with X93314.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1365 UPDATE AAC(6')-I30 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-I30 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. UPDATED accession with AY289608.1 " 3 UPDATE Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics penam; reduced permeability to antibiotic; penem; carbapenem; cephalosporin; cefepime; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; ARO_category; model_name "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics " 492 UPDATE Clostridium butyricum catB antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with catB is a chromosome-encoded variant of the cat gene found in Clostridium butyricum. UPDATED accession with M93113.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 359 UPDATE TEM-112 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY589493.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 493 UPDATE TEM-84 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF427130.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 24 UPDATE fusB fusidic acid; antibiotic target protection; Target protecting FusB-type protein conferring resistance to Fusidic acid; model_sequences "UPDATED accession with AY047358.1 " 25 UPDATE CTX-M-121 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-121 is a beta-lactamase found in Escherichia coli. UPDATED accession with JN790862.1 " 26 UPDATE VEB-3 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VEB-3 is a beta-lactamase found in Enterobacter cloacae. UPDATED accession with AY536519.1 UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 3319 UPDATE AAC(6')-Ian AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; model_sequences "UPDATED accession with AP014611.1 " 3318 UPDATE ADC-60 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. " 1267 UPDATE QnrB40 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; ARO_category "UPDATED ARO_description with QnrB40 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 27 UPDATE lnuA antibiotic inactivation; lincosamide nucleotidyltransferase (LNU); lincosamide antibiotic; ARO_description "UPDATED ARO_description with lnuA is a plasmid-mediated nucleotidyltransferase found in Staphylococcus chromogenes. " 3313 UPDATE ACT-8 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 784 UPDATE AAC(6')-Iv AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; model_sequences "UPDATED accession with AF031330.1 " 785 UPDATE OXY-2-9 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-9 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with FJ785625.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 786 UPDATE vanHO glycopeptide antibiotic; glycopeptide resistance gene cluster; vanH; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanHO, is a vanH variant in the vanO gene cluster. UPDATED accession with KF478993.1 UPDATED model_name with vanH gene in vanO cluster UPDATED ARO_name with vanH gene in vanO cluster " 787 UPDATE dfrA23 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA23 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. UPDATED partial with 0 UPDATED sequence with ATGCCAACAGTTGAGATTATTGTTGCAGTTGATCCTGTTGGGGGATTTGGCCGGAATGGCCAAATCCCTTGGACGTGCAAGGAAGACATGAAGCGCTTCACCACCATATCCAAAGAGATTCGAGTGTGTGTGATGGGGAAGAACACATACAAAGACATGCTCGATATGCAAATGAAGAAGGAAGGCGCTGAAGAACGAATCAAAGAGAAGGGAATTCTTCCGGAGCGCGAATCTTACGTCGTGTCCTCGACTTTGAAGCCCGAGGACGTCATTGGAGCCACGGTAGTTCCGGACCTACGTGCGGTGCTCAATCAATATCACGACAGCGATCAACGAATAGCTGTCATTGGTGGAGAAAAGCTGTACGTGCAAGCCCTCGCATCTGCCACAAAAGTCCACATGACGGTAATGCACAAGCCATATAACTGCGATCGGACGTTGCCGATGTCATACATCGACAAAAAGTTTGTTGCAGGTCAAGGGTCTATCACCATTCAAACTGCGGTAGATGGTGAGACCCATCCCGTGAAGTTCATCACATATGAGCGCGCTCGGCCGTAA UPDATED fmax with 7303 UPDATED accession with AJ746361.2 UPDATED fmin with 6742 UPDATED strand with - UPDATED NCBI_taxonomy_name with Salmonella enterica subsp. enterica serovar Typhimurium UPDATED NCBI_taxonomy_id with 90371 UPDATED NCBI_taxonomy_cvterm_id with 35732 UPDATED accession with CAG34233.2 UPDATED sequence with MPTVEIIVAVDPVGGFGRNGQIPWTCKEDMKRFTTISKEIRVCVMGKNTYKDMLDMQMKKEGAEERIKEKGILPERESYVVSSTLKPEDVIGATVVPDLRAVLNQYHDSDQRIAVIGGEKLYVQALASATKVHMTVMHKPYNCDRTLPMSYIDKKFVAGQGSITIQTAVDGETHPVKFITYERARP " 781 UPDATE QnrB25 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB25 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with HQ172108.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 782 UPDATE OXA-63 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY619003.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 783 UPDATE NDM-1 penam; antibiotic inactivation; imipenem; cephamycin; carbapenem; cephalosporin; NDM beta-lactamase; amoxicillin; clavulanic acid; meropenem; amoxicillin-clavulanic acid; ertapenem; model_sequences; ARO_category "UPDATED accession with FN396876.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1726 UPDATE FOX-4 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with FOX-4 is a beta-lactamase found in Escherichia coli. UPDATED accession with AJ277535.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 1727 UPDATE SHV-73 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAATTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGTAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAGGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 874 UPDATED accession with AM176548.2 UPDATED fmin with 16 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47128.2 UPDATED sequence with MRIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1724 UPDATE vanHM glycopeptide antibiotic; glycopeptide resistance gene cluster; vanH; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanHM, is a vanH variant in the vanM gene cluster. UPDATED accession with FJ349556.1 UPDATED model_name with vanH gene in vanM cluster UPDATED ARO_name with vanH gene in vanM cluster " 788 UPDATE SHV-46 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY210887.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 789 UPDATE IMP-43 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-43 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AB777500.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1720 UPDATE tap tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AJ000283.1 " 1721 UPDATE Mycobacterium leprae folP with mutation conferring resistance to dapsone antibiotic target alteration; sulfone antibiotic; dapsone resistant dihydropteroate synthase folP; dapsone; model_sequences; ARO_category "UPDATED accession with AL450380.1 UPDATED category_aro_description with Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Thus acts as a competitive inhibitor of folP. Point mutation within the folP gene results in lowered affinity of dapsone for folP. " 729 UPDATE CTX-M-8 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-8 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AF189721.1 " 468 UPDATE Erm(37) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with AL123456.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 5623 UPDATE PFM-2 carbapenem; antibiotic inactivation; PFM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4386 UPDATE BlaB-25 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 60 UPDATE QnrS6 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrS6 is a plasmid-mediated quinolone resistance protein found in Aeromonas hydrophila. UPDATED accession with HQ631376.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3311 UPDATE ACT-38 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 62 UPDATE CMY-42 antibiotic inactivation; cephalosporin; ceftazidime; cephamycin; CMY beta-lactamase; cefoxitin; ARO_description; model_sequences "UPDATED ARO_description with CMY-42 is a plasmid-borne AmpC cephalosporinase gene found in Escherichia coli. UPDATED accession with HM146927.1 " 63 UPDATE AAC(6')-Ib AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; plazomicin; tobramycin; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ib is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in K. pneumoniae, P. mirabilis, P. aeruginosa, S. enterica, K. oxytoca, S. maltophilia, E. cloacae and V. cholerae. UPDATED accession with JQ808129.1 " 64 UPDATE CMY-70 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JX440350.1 " 5621 UPDATE PER-9 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 66 UPDATE SHV-41 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF535129.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3310 UPDATE ADC-11 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with ADC-11 is a class C beta-lactamase found in Acinetobacter baumannii. " 68 UPDATE TEM-132 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY491682.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 69 UPDATE aadA23 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA23 is an integron-encoded aminoglycoside nucleotidyltransferase gene in S. enterica. UPDATED accession with AJ809407.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 5620 UPDATE PER-8 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 123 UPDATE SHV-64 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ174304.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1371 UPDATE CTX-M-26 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-26 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY157676.1 " 1588 UPDATE QnrB50 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB50 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JX440357.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1370 UPDATE AAC(6')-Ib10 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with U59183.1 " 1582 UPDATE dfrA5 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA5 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. UPDATED accession with DQ278190.1 " 3315 UPDATE ADC-30 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. " 1580 UPDATE catIII antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with catIII is a plasmid-encoded variant of the cat gene found in Shigella flexneri. UPDATED accession with X07848.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1581 UPDATE ACT-3 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACT-3 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with EF125013.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1586 UPDATE CTX-M-32 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-32 is a beta-lactamase found in Escherichia coli. UPDATED accession with AJ557142.1 " 1373 UPDATE CMY-26 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-26 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AB300358.1 " 2433 UPDATE lfrA efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; major facilitator superfamily (MFS) antibiotic efflux pump; antibiotic efflux; model_name "UPDATED model_name with lfrA " 1038 UPDATE cmlB1 antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmlB1 is a plasmid-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica. UPDATED accession with AM296481.1 " 404 UPDATE OXA-217 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN603240.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3317 UPDATE ADC-59 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. " 508 UPDATE tetA(P) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with L20800.1 " 2432 UPDATE Klebsiella pneumoniae OmpK35 penam; reduced permeability to antibiotic; penem; carbapenem; cephalosporin; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; resistance by absence; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). " 1032 UPDATE OXA-365 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF885217.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 403 UPDATE dfrA8 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica. UPDATED accession with KJ174469.1 " 1030 UPDATE vanZA vanZ; glycopeptide resistance gene cluster; teicoplanin; antibiotic target alteration; vancomycin; glycopeptide antibiotic; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanZA, is a vanZ variant found in the vanA gene cluster. UPDATED accession with M97297.1 UPDATED model_name with vanZ gene in vanA cluster UPDATED ARO_name with vanZ gene in vanA cluster " 3316 UPDATE ADC-58 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. " 502 UPDATE aadA17 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA17 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Aeromonas media. UPDATED partial with 0 UPDATED sequence with ATGAGGGTAGCGGTGACCATCGAAATTTCGAACCAACTATCAGAGGTGCTAAGCGTCATCGAGCGCCATCTCGAACCGACGTTGCTGGCCGTACATTTGTACGGCTCCGCAGTGGATGGCGGCCTGAAGCCACACAGTGATATTGATTTGCTGGTTACGGTGACCGTAAGGCTTGATGAAACAACGCGGCGAGCTTTGATCAACGACCTTTTGGAAACTTCGGCTTCCCCTGGAGAGAGCGAGATTCTCCGCGCTGTAGAAGTCACCATTGTTGTGCACGACGACATCATTCCGTGGCGTTATCCAGCTAAGCGCGAACTGCAATTTGGAGAATGGCAGCGCAATGACATTCTTGCAGGTATCTTCGAGCCAGCCACGATCGACATTGATCTAGCTATCCTGCTTACAAAAGCAAGAGAACATAGCGTTGCCTTGGTAGGTCCGGCAGCGGAGGAATTCTTTGACCCGGTTCCTGAACAGGATCTATTCGAGGCGCTGAGGGAAACCTTGAAGCTATGGAACTCGCAGCCCGACTGGGCCGGCGATGAGCGAAATGTAGTGCTTACGTTGTCCCGCATTTGGTACAGCGCAATAACCGGCAAAATCGCGCCGAAGGATGTCGCTGCCGACTGGGCAATAAAACGCCTACCTGCCCAGTATCAGCCCGTCTTACTTGAAGCTAAGCAAGCTTATCTGGGACAAAAAGAAGATCACTTGGCCTCACGCGCAGATCACTTGGAAGAATTTATTCGCTTTGTGAAAGGCGAGATCATCAAGTCAGTTGGTAAATGA UPDATED fmax with 2582 UPDATED accession with FJ460181.2 UPDATED fmin with 1790 UPDATED strand with + UPDATED NCBI_taxonomy_name with Aeromonas media UPDATED NCBI_taxonomy_id with 651 UPDATED NCBI_taxonomy_cvterm_id with 39526 UPDATED accession with ACK43806.1 UPDATED sequence with MRVAVTIEISNQLSEVLSVIERHLEPTLLAVHLYGSAVDGGLKPHSDIDLLVTVTVRLDETTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPATIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLFEALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQPVLLEAKQAYLGQKEDHLASRADHLEEFIRFVKGEIIKSVGK UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 503 UPDATE CTX-M-69 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-69 is a beta-lactamase found in Escherichia coli. UPDATED accession with EU402393.1 " 500 UPDATE OXA-164 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-164 is a beta-lactamase found in A. baumannii. UPDATED accession with GU831575.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 501 UPDATE AAC(3)-VIIIa antibiotic inactivation; AAC(3); aminoglycoside antibiotic; neomycin; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-VIIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces fradiae. UPDATED accession with M55426.1 " 1212 UPDATE OXA-141 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-141 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with EF552405.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1213 UPDATE nalD sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; nalidixic acid; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; trimethoprim; azithromycin; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1210 UPDATE novA efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; aminocoumarin antibiotic; novobiocin; antibiotic efflux; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAGTCCGCACTCTCGACCTGGAAGCCCTCGGACCGGCCGCCGGATCCGACACTGCCCGAGCCGCCGGCCCAGCTGCGCCGCATCTTCCGGCTCTTCCGCCCGTACCGCGGCAGGCTCGCCGTCGTCGGCCTGCTCGTCGGCGCCTCGTCGCTGGTGGCCGTCGCCTCGCCGTTCATGCTGCGCGAGATCCTCGACACCGCGATCCCGCAGGGCCGCACCGGGCTGCTCAGCCTGCTCGCCCTCGGCATGATCCTGACCGCCGTCCTCAGCAGCGTCTTCGGCGTCGTCCAGACCCTCATCTCCACGACGGTCGGCCAGCGCGTCATGCACGACCTGCGCACCGCCGTCTACGCGCAGCTCCAGCGCATGCCCCTCGCGTTCTTCACCCGCACCCGCACCGGTGAGGTCCAGTCCCGGATAGCCAACGACATCGGCGGCATGCAGGCGACCGTCACCTCAACCGCCACGTCGCTGGTCTCCAACCTCACCGCCGTCATCGCCACCGTCGTCGCGATGCTCGCGCTGGACTGGCGGCTGACCGTCGTCTCGCTGCTCCTGCTGCCGGTGTTCGTCTGGATCAGCCGCCGCGTCGGCCGTGAGCGCAAACGGATCACCCTGCAACGGCAGAAGCAGATGGCCACGATGGCCGCCACGGTCACGGAGTCGCTGTCGGTCAGCGGCATCCTCCTCGGCCGCACGATGGGGCGCGCCGACTCGCTCACCAGATCCTTCGCCGAGGAGTCCGAGCGACTCGTCGACCTGGAGGTCCGCTCCAACATGGCCGGGCGGTGGCGGATGTCCGTCATCGGCATCGTCATGGCCGCCATGCCCGCCGTCATCTACTGGGCGGCCGGCTTCGTCCTCCAGTCCGGCGGCACGGTCGTCTCCATCGGCACACTCGTCGCCTTCGTCTCCCTCCAGCAGGGCCTCTTCCGCCCGGCCGTGAGCCTGCTCGCCACCGGCGTGCAGATGCAGACGTCCCTCGCGCTCTTCCAGCGCATCTTCGAATATCTCGACCTGCCCGTCGACATCACCGAACCCGAGCGTCCGGTGGCCCTCGACAAGGTCCGGGGCGAAGTGCGCTTCGACGGCGTCGACTTCAGTTACGAGGAGAAGGACGGCAACACCCTCCACGGCCTGGATCTGACCGTCCCGGCCGGCGGCAGCCTCGCCGTCGTCGGTCCCACCGGATCGGGCAAGTCGACCCTGAGCTATCTCGTGCCGCGTCTGTACGACGTGACGGGCGGCCGGGTCCTGCTCGACGGCGTCGACGTACGCGACCTGGCCTTCGACACCCTCGCCCGCGCGGTGGGCGTCGTGTCGCAGGAGACGTATCTCTTCCACGCCTCCGTCGCCGACAACCTCCGCTTCGCCAAACCGGACGCGACGGACGAGGAGATCGAGAAGGCGGCCAGGGCCGCCCAGATCCACGAGCACATCGTCACCCTGCCCGACGGGTACGACACACTGGTCGGCGAGCGCGGATACCGGTTCTCCGGCGGCGAGAAACAGCGCCTCGCGATCGCCCGCACCATCCTGCGCGACCCGCCCGTCCTCGTGCTGGACGAGGCGACGAGCGCGCTCGACACCCGTACCGAACACGCGGTCCAGCAGGCCATCGACTCCCTCTCCGAGGGCCGTACGACCATCACCATCGCCCACCGGCTCTCCACGGTGCGCGACGCCGACCAGATCGTCGTCCTCGACGCCGGTCGCATAGCCGAGCGCGGCACGCACGAGGAGCTGATCGACCGGGACGGCAGGTACGCGGCGCTCGTCCGCCGGGACGGCGCGCCGGCGCCCGCGCCCGTGCCCGCCCGGGACGAGCGCGTGGGCGCCGCCTGA UPDATED fmax with 1848 UPDATED accession with AF170880.4 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Streptomyces niveus UPDATED NCBI_taxonomy_id with 193462 UPDATED NCBI_taxonomy_cvterm_id with 39503 UPDATED accession with AAF67494.2 UPDATED sequence with MKSALSTWKPSDRPPDPTLPEPPAQLRRIFRLFRPYRGRLAVVGLLVGASSLVAVASPFMLREILDTAIPQGRTGLLSLLALGMILTAVLSSVFGVVQTLISTTVGQRVMHDLRTAVYAQLQRMPLAFFTRTRTGEVQSRIANDIGGMQATVTSTATSLVSNLTAVIATVVAMLALDWRLTVVSLLLLPVFVWISRRVGRERKRITLQRQKQMATMAATVTESLSVSGILLGRTMGRADSLTRSFAEESERLVDLEVRSNMAGRWRMSVIGIVMAAMPAVIYWAAGFVLQSGGTVVSIGTLVAFVSLQQGLFRPAVSLLATGVQMQTSLALFQRIFEYLDLPVDITEPERPVALDKVRGEVRFDGVDFSYEEKDGNTLHGLDLTVPAGGSLAVVGPTGSGKSTLSYLVPRLYDVTGGRVLLDGVDVRDLAFDTLARAVGVVSQETYLFHASVADNLRFAKPDATDEEIEKAARAAQIHEHIVTLPDGYDTLVGERGYRFSGGEKQRLAIARTILRDPPVLVLDEATSALDTRTEHAVQQAIDSLSEGRTTITIAHRLSTVRDADQIVVLDAGRIAERGTHEELIDRDGRYAALVRRDGAPAPAPVPARDERVGAA " 633 UPDATE OXA-355 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297584.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1216 UPDATE SHV-119 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ776406.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 635 UPDATE OXA-332 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203106.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 636 UPDATE CFE-1 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CFE-1 is a beta-lactamase found in Escherichia coli. UPDATED accession with AB107899.1 " 637 UPDATE OXY-6-2 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-6-2 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ871875.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 638 UPDATE ACT-16 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACT-16 is a beta-lactamase found in Enterobacteriaceae. UPDATED accession with AB737978.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 639 UPDATE AAC(3)-IV antibiotic inactivation; AAC(3); aminoglycoside antibiotic; plazomicin; apramycin; ARO_description "UPDATED ARO_description with AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri. " 1218 UPDATE TEM-219 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM114268.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1219 UPDATE vanRN glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRN, is a vanR variant found in the vanN gene cluster. UPDATED accession with JF802084.1 UPDATED model_name with vanR gene in vanN cluster UPDATED ARO_name with vanR gene in vanN cluster " 1647 UPDATE MexI antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and antiseptics; tetracycline; ARO_category; model_name "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 UPDATED model_name with MexI " 4378 UPDATE BlaB-17 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1394 UPDATE OXA-257 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-257 is a beta-lactamase found in A. bereziniae. UPDATED accession with KC567681.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5658 UPDATE SHV-191 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5659 UPDATE SIM-2 carbapenem; penam; cephalosporin; antibiotic inactivation; SIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4372 UPDATE BlaB-11 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 780 UPDATE CARB-9 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-9 is a beta-lactamase found in Vibrio cholerae. UPDATED accession with AY248038.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4370 UPDATE BlaB-1 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2416 UPDATE abcA penam; peptide antibiotic; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; daptomycin; cefotaxime; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; moenomycin A1; methicillin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4376 UPDATE BlaB-15 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4377 UPDATE BlaB-16 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4374 UPDATE BlaB-13 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4375 UPDATE BlaB-14 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 987 UPDATE CTX-M-4 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-4 is a beta-lactamase found in Salmonella typhimurium. UPDATED accession with Y14156.1 " 2899 UPDATE Vibrio anguillarum chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with A chloramphenicol resistance determinant described in a Vibrio anguillarum plasmid sequence. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1728 UPDATE OXA-42 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-42 is a beta-lactamase found in Burkholderia pseudomallei. UPDATED accession with AJ488302.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1291 UPDATE TEM-177 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FN652295.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2895 UPDATE Enterococcus faecium chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with A chloramphenicol resistance determinant described in an Enterococcus faecium plasmid. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 2894 UPDATE Streptococcus suis chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_category "UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 2897 UPDATE Enterococcus faecalis chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with A chloramphenicol acetyltransferase and resistance determinant described in Enterococcus faecalis. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1729 UPDATE CTX-M-66 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-66 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with EF576988.1 " 2891 UPDATE Bacillus clausii chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_description; ARO_name; model_sequences; model_name; ARO_category "UPDATED ARO_description with A chloramphenicol resistance determinant described in Alkalihalobacillus clausii. UPDATED ARO_name with Alkalihalobacillus clausii chloramphenicol acetyltransferase UPDATED NCBI_taxonomy_name with Alkalihalobacillus clausii UPDATED model_name with Alkalihalobacillus clausii chloramphenicol acetyltransferase UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 2890 UPDATE Agrobacterium fabrum chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_category "UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 2893 UPDATE Campylobacter coli chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_category "UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1106 UPDATE NDM-5 penam; antibiotic inactivation; piperacillin-tazobactam; cephalosporin; carbapenem; ceftazidime; NDM beta-lactamase; cephamycin; piperacillin; tazobactam; cefoxitin; ertapenem; model_sequences; ARO_category "UPDATED accession with JN104597.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1107 UPDATE PDC-2 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED accession with FJ666064.1 " 1104 UPDATE acrB penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1105 UPDATE AAC(3)-VIa antibiotic inactivation; aminoglycoside antibiotic; gentamicin C; AAC(3); gentamicin B; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-VIa is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae, S. enterica and E. coli. UPDATED accession with M88012.1 " 1102 UPDATE QnrB29 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB29 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with HM439649.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1103 UPDATE CMY-17 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with AY513266.1 " 1452 UPDATE TEM-216 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF944358.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1453 UPDATE vanYD glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanYD, is a vanY variant found in the vanD gene cluster. UPDATED accession with AY082011.1 UPDATED model_name with vanY gene in vanD cluster UPDATED ARO_name with vanY gene in vanD cluster " 1898 UPDATE OXA-379 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF986260.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1458 UPDATE TEM-157 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ909059.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1459 UPDATE CTX-M-78 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-78 is a beta-lactamase found in Kluyvera georgiana. UPDATED partial with 0 UPDATED sequence with ATGATGAGAAAAAGCGTAAGGCGGGCGATATTAATGACGACAGCCTGTGTTTCGCTGCTGTTGGCCAGTGTGCCGCTGTATGCCCAAGCGAACGATATTCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGGGGACGACTGGGTGTGGCGTTGATTAACACCGCCGATAACACGCAGACGCTCTACCGCGCCGACGAGCGTTTTGCTATGTGCAGCACCAGTAAAGTGATGGCGGCGGCGGCGGTGCTTAAGCAAAGTGAAACGCAAAAAGACTTACTGAGTCAGCGGGTTGAAATTAAGTCCTCAGACTTGATTAACTACAACCCAATCGCTGAAAAGCACGTCAATGGCACGATGACACTCGGGGAGCTGAGCGCGGCGGCGCTGCAGTACAGCGATAATACTGCCATGAATAAGCTGATTGCCCATCTCGGGGGGCCGGGTAAAGTGACGGCATTTGCTCGCGTGATTGGCGATGACACTTTCCGGCTCGATCGTACCGAGCCGACGCTCAACACCGCGATCCCCGGCGACCCGCGCGATACCACCACGCCGTTAGCGATGGCGCAGACTCTACGCAATCTCACATTGGGCAATGCCCTGGGTGACACTCAGCGTGCGCAGCTGGTGACGTGGCTGAAAGGCAACACCACCGGCGCTGCCAGCATTCAGGCAGGGCTACCCACATCGTGGGTTGTCGGGGATAAAACCGGCAGCGGCGATTATGGTACGACGAATGATATCGCGGTTATTTGGCCGGAAGGTCGCGCGCCGCTCGTTCTGGTGACTTACTTCACCCAGCCGGAGCCGAAGGCAGAGAGCCGTCGTGACGTGCTCGCTGCTGCCGCCAGAATAGTCACCGACGGTTATTAG UPDATED fmax with 876 UPDATED accession with AM982522.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Kluyvera georgiana UPDATED NCBI_taxonomy_id with 73098 UPDATED NCBI_taxonomy_cvterm_id with 36929 UPDATED accession with CAQ42481.2 UPDATED sequence with MMRKSVRRAILMTTACVSLLLASVPLYAQANDIQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKDLLSQRVEIKSSDLINYNPIAEKHVNGTMTLGELSAAALQYSDNTAMNKLIAHLGGPGKVTAFARVIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRNLTLGNALGDTQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLVLVTYFTQPEPKAESRRDVLAAAARIVTDGY " 1108 UPDATE Enterococcus faecium liaS mutant conferring daptomycin resistance antibiotic efflux; protein(s) and two-component regulatory system modulating antibiotic efflux; peptide antibiotic; antibiotic target alteration; daptomycin resistant liaS; daptomycin; model_sequences "UPDATED accession with CP003583.1 " 4830 UPDATE OXA-491 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4080 UPDATE DfrA36 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with DfrA36 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally described by Wuthrich et al., 2019, and isolated from Escherichia coli. UPDATED accession with NG_065842.1 " 4081 UPDATE DfrA38 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED accession with NG_071175.1 " 4085 UPDATE dfr22 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with Dfr22 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally detected by Grape et al., (2005) and isolated from Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGAACCCGGAATTGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGCCCCGATATTCCCTGGAAAATCCCGGGTGAGCAAAAGATCTTTCGCAGGCTCACCGAGGGCAAAGTGGTCGTTATGGGCCGCAAGACGTTTGAGTCCATAGGCAAGCCCTTACCAAACCGCCGCACAGTGGTGCTCTCGCGCCAAGCCAGTTATAGCGCTGCTGGTTGTGCAGTTGTTTCAACGCTGTCGCAGGCTATTGCCATCGCAGCCGAACACGGCAAAGAGCTCTACGTGGCCGGCGGAGCCGAGGTATATGCACTGGCACTACCTCGTGCCGACGGCGTCTTTCTATCTGAGGTACATCAAACCTTCGAGGGTGACGCCTTCTTCCCTGTGCTCGACGAAGCAGAATTCGAGGTTGTCTCAGCCGAAACCGTTCAAGCCACAATCACGTACACGCACTCCGTCTATGCACGTCGTAACGGCTAA UPDATED fmax with 822 UPDATED accession with AJ628423.2 UPDATED fmin with 324 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with CAF31623.1 UPDATED sequence with MNPELVRIYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRRTVVLSRQASYSAAGCAVVSTLSQAIAIAAEHGKELYVAGGAEVYALALPRADGVFLSEVHQTFEGDAFFPVLDEAEFEVVSAETVQATITYTHSVYARRNG " 654 UPDATE dfrA26 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA26 is an integron-encoded dihydrofolate reductase found in Escherichia coli. UPDATED accession with AM403715.1 " 1722 UPDATE TEM-184 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FR848831.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3866 UPDATE PDC-56 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-56 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 4883. " 3865 UPDATE PDC-67 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-67 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 5065. " 1723 UPDATE IMP-44 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-44 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AB777501.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 322 UPDATE FEZ-1 carbapenem; FEZ beta-lactamase; cephalosporin; antibiotic inactivation; penam; model_sequences; model_name; ARO_category "UPDATED accession with Y17896.1 UPDATED model_name with FEZ-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3837 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide antibiotic target alteration; prothionamide; prothionamide resistant ethA; ARO_description; ARO_category "UPDATED ARO_description with Mutations in Mycobacterium tuberculosis ethA conferring resistance to prothionamide, an analogue to isoniazid. UPDATED category_aro_description with Mutations in ethA conferring resistance to prothionamide, an analogue of isoniazid. " 467 UPDATE CARB-3 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-3 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with S46063.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1577 UPDATE AAC(6')-32 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-32 is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. UPDATED accession with EF614235.1 " 323 UPDATE aadA9 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA9 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in C. glutamicum. UPDATED accession with DQ390458.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 5722 UPDATE VIM-73 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5723 UPDATE YEM-1 carbapenem; antibiotic inactivation; YEM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5720 UPDATE VIM-71 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5721 UPDATE VIM-72 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1837 UPDATE CTX-M-59 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-59 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with DQ408762.1 " 5724 UPDATE ZOG-1 carbapenem; antibiotic inactivation; ZOG beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5636 UPDATE RAHN-1 antibiotic inactivation; cephalosporin; RAHN beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 466 UPDATE CTX-M-76 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with AM982520.1 " 4832 UPDATE OXA-494 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 320 UPDATE Streptococcus pneumoniae PBP2x conferring resistance to amoxicillin penam; cephamycin; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; amoxicillin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with PBP2x is a penicillin-binding protein found in Streptococcus pneumoniae. UPDATED accession with JN645706.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. " 3917 UPDATE CMY-157 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_055587.1 " 4923 UPDATE OXA-597 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3915 UPDATE CMY-145 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_052649.1 " 3914 UPDATE CMY-125 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_048795.1 " 3913 UPDATE CMY-124 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_048794.1 " 3912 UPDATE CMY-141 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_051215.1 " 3911 UPDATE CMY-142 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_051753.1 " 2137 UPDATE Escherichia coli EF-Tu mutants conferring resistance to kirromycin antibiotic target alteration; elfamycin antibiotic; kirromycin; elfamycin resistant EF-Tu; ARO_description "UPDATED ARO_description with Sequence variants of Escherichia coli elongation factor Tu that confer resistance to kirromycin. " 1347 UPDATE OXA-425 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-425 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem-resistant. UPDATED accession with KM588353.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4921 UPDATE OXA-595 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3919 UPDATE CMY-155 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_055473.1 " 3918 UPDATE CMY-171 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_068165.1 " 4920 UPDATE OXA-594 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4798 UPDATE ORN-4 carbapenem; ORN beta-lactamase; cephalosporin; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4799 UPDATE ORN-5 carbapenem; ORN beta-lactamase; cephalosporin; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1636 UPDATE QnrB57 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB57 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JX259318.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4794 UPDATE OKP-D-1 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4796 UPDATE ORN-2 carbapenem; ORN beta-lactamase; cephalosporin; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4797 UPDATE ORN-3 carbapenem; ORN beta-lactamase; cephalosporin; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4790 UPDATE OKP-B-40 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4791 UPDATE OKP-B-41 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4792 UPDATE OKP-B-45 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4793 UPDATE OKP-C-1 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4152 UPDATE ACT-61 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4153 UPDATE ACT-62 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4150 UPDATE ACT-59 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4151 UPDATE ACT-60 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4156 UPDATE ACT-65 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4157 UPDATE ACT-66 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4154 UPDATE ACT-63 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4155 UPDATE ACT-64 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4158 UPDATE ACT-67 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4159 UPDATE ACT-68 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 951 UPDATE ACT-15 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with JX440356.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 950 UPDATE ErmX antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 326 UPDATE OXA-225 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN638887.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4034 UPDATE PDC-376 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-376 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 216 UPDATE LEN-9 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with LEN-9 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 217 UPDATE vanXA antibiotic target alteration; glycopeptide resistance gene cluster; teicoplanin; glycopeptide antibiotic; vanX; vancomycin; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXA, is a vanX variant found in the vanA gene cluster. UPDATED accession with M97297.1 UPDATED model_name with vanX gene in vanA cluster UPDATED ARO_name with vanX gene in vanA cluster " 214 UPDATE SHV-121 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ661362.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 215 UPDATE bcrC peptide antibiotic; undecaprenyl pyrophosphate related proteins; bacitracin B; bacitracin F; bacitracin A; antibiotic target alteration; model_sequences "UPDATED accession with L20573.1 " 212 UPDATE Staphylococcus aureus parC conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutation in Staphylococcus aureus parC resulting in fluoroquinolone resistance. UPDATED model_name with Staphylococcus aureus parC conferring resistance to fluoroquinolones " 213 UPDATE OXA-21 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-21 is a beta-lactamase found in A. baumannii. UPDATED partial with 0 UPDATED sequence with ATGGCAATCCGAATCTTCGCAATACTTTTCTCCACTTTTGTTTTTGGCACGTTCGCGCATGCACAAGAAGGCATGCGCGAACGTTCTGACTGGCGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAACAGATCGTGTCATATTGGTTTTTGATCAGGTGCGGTCAGAGAAACGCTACTCGCCGGCCTCGACATTCAAGATTCCACATACACTTTTTGCACTTGACGCAGGCGCTGCACGTGATGAGTTTCAAGTTTTCCGATGGGACGGCATCAAAAGAAGCTTTGCAGCTCACAACCAAGACCAAGACTTGCGATCAGCAATGCGGAATTCTACTGTCTGGATTTATGAGCTATTTGCAAAAGAGATCGGTGAAGACAAGGCTCGACGCTATTTGAAGCAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGATGGCAATCTTGCTATCGCGGCACAAGAACAGATTGCATTTCTCAGGAAGCTCTATCATAACGAGTTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGACCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGCGCAAAGACGGGCTGGGAAGGCCGCATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCCCCGTATTTTTCGCACTGAATATTGATACGCCAAACAGGATGGATGACCTTTTCAAAAGGGAGGCAATAGTGCGGGCAATCCTTCGCTCTATCGAAGCGTTGCCGCCCAACCCGGCAGTCAACTCGGACGCAGCGCGATAA UPDATED fmax with 828 UPDATED accession with Y10693.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with CAA71699.2 UPDATED sequence with MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILVFDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLRSAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQIAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 210 UPDATE SHV-35 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY070258.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 211 UPDATE TEM-206 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC783461.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 983 UPDATE GES-20 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-20 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with JN596280.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 5009 UPDATE OXA-697 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4036 UPDATE PDC-231 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-231 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 1186 UPDATE OXA-327 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203101.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 218 UPDATE npmA antibiotic target alteration; aminoglycoside antibiotic; 16S rRNA methyltransferase (A1408); model_sequences "UPDATED partial with 0 UPDATED sequence with TTGTTAATACTCAAAGGAACAAAGACGGTTGATTTATCAAAAGATGAATTGACAGAAATAATAGGTCAGTTTGATCGTGTGCATATAGATTTGGGTACTGGAGACGGTAGAAATATATATAAACTTGCAATTAATGATCAAAACACTTTCTATATCGGAATAGATCCGGTAAAAGAAAACTTGTTTGATATATCCAAAAAAATTATAAAGAAGCCCTCAAAAGGAGGGCTATCTAATGTGGTGTTTGTTATTGCAGCTGCAGAGTCTCTCCCTTTTGAATTGAAAAACATTGCTGATTCAATTTCCATTTTGTTTCCTTGGGGGACATTGCTTGAATATGTAATTAAACCGAATAGAGATATTCTTTCGAATGTTGCAGATTTGGCTAAAAAAGAAGCTCACTTTGAATTTGTGACCACATACTCAGATTCATACGAAGAAGCGGAAATAAAAAAAAGAGGACTTCCTCTTTTAAGTAAGGCCTATTTTTTGAGCGAACAATACAAAGCTGAATTATCAAACTCAGGTTTTCGCATTGATGATGTTAAGGAATTGGACAATGAGTATGTAAAACAGTTTAATTCTCTTTGGGCAAAGCGATTAGCTTTTGGGCGAAAACGTTCTTTCTTTCGAGTTTCTGGCCATGTTTCAAAACATTAA UPDATED fmax with 91823 UPDATED accession with AB261016.2 UPDATED fmin with 91163 UPDATED strand with - UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with BAF80809.1 UPDATED sequence with MLILKGTKTVDLSKDELTEIIGQFDRVHIDLGTGDGRNIYKLAINDQNTFYIGIDPVKENLFDISKKIIKKPSKGGLSNVVFVIAAAESLPFELKNIADSISILFPWGTLLEYVIKPNRDILSNVADLAKKEAHFEFVTTYSDSYEEAEIKKRGLPLLSKAYFLSEQYKAELSNSGFRIDDVKELDNEYVKQFNSLWAKRLAFGRKRSFFRVSGHVSKH " 219 UPDATE OKP-A-12 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-12 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGCATTCGCCAGCCCTCAGCCGCTCGAGCAAGTTACACGCAGCGAAAGTCAGCTGGCGGGCCGCGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCACTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGAGACGAACAGCTGGATCGGCGGATCCGCTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGTGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTTGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAGCTCAATGAAGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCAGCCAGCATGGCCGCCACCCTGCGCAAGCTGCTAACCAGCCACGCGCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCAGGTGGCCGGCCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGCGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGAACGGCAAAGCGGAGCGCATCGTGGTGATCTATCTGCGGGATACGCCGGCGACCATGGCCGAACGTAACCAGCAGATCGCCAGAATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 879 UPDATED accession with AM850916.2 UPDATED fmin with 18 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12354.2 UPDATED sequence with MRYVRLCLISLIAALPLAAFASPQPLEQVTRSESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIRYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMAATLRKLLTSHALSARSQQQLLQWMVDDQVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPNGKAERIVVIYLRDTPATMAERNQQIARIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4837 UPDATE OXA-502 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2476 UPDATE Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin antibiotic target alteration; 16S rRNA with mutation conferring resistance to pactamycin; pactamycin; ARO_description; ARO_category; model_name "UPDATED ARO_description with Point mutations in Halobacterium 16S rRNA that confer resistance to pactamycin antibiotic. UPDATED category_aro_description with Point mutations in bacterial 16S rRNA that confer resistance to antibiotic pactamycin. UPDATED category_aro_description with Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor. UPDATED model_name with Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin " 956 UPDATE TEM-88 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY027590.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 36 UPDATE Mycobacterium leprae gyrA conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; fluoroquinolone resistant gyrA; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; model_sequences; model_name "UPDATED accession with AL450380.1 UPDATED model_name with Mycobacterium leprae gyrA conferring resistance to fluoroquinolones " 939 UPDATE CTX-M-113 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JF274247.1 " 4 UPDATE SHV-52 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ845196.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 324 UPDATE QnrB54 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB54 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED partial with 0 UPDATED sequence with ATGGCACTGGCACTCGTTAGCGAAAAAATTGACAGAAACCGCTTCACCGGTGAGAAAATTGAAAATAGTACATTTTTTAACTGTGATTTTTCAGGTGCCGACCTGAGCGGCACTGAATTTATCGGCTGTCAGTTCTATGATCGTGAAAGCCAGAAAGGGTGCAATTTTAGTCGTGCGATGCTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAATGCCAGTGCGCTTGGCATTGAAATTCGCCACTGTCGTGCGCAAGGCGCAGATTTCCGCGGCGCAAGCTTTATGAATATGATCACTACTCGCACCTGGTTTTGTAGTGCATATATCACTAACACAAATCTAAGCTACGCCAATTTTTCGAAAGTCGTGCTGGAAAAGTGTGAGCTGTGGGAAAACCGTTGGATGGGTACCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCGACTTTCGACTGGCGAGCAGCAAACTTCACACATTGCGATCTGACCAATTCGGAGTTGGGTGACTTAGATATTCGGGGCGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCATCGTTGCTCATGGAACGTCTTGGCATCGCGATTATTGGCTAG UPDATED fmax with 1231 UPDATED accession with HE820727.2 UPDATED fmin with 586 UPDATED strand with + UPDATED NCBI_taxonomy_name with Citrobacter freundii UPDATED NCBI_taxonomy_id with 546 UPDATED NCBI_taxonomy_cvterm_id with 36915 UPDATED accession with CCI51002.2 UPDATED sequence with MALALVSEKIDRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGTQVLGATFSGSDLSGGEFSTFDWRAANFTHCDLTNSELGDLDIRGVDLQGVKLDNYQASLLMERLGIAIIG UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4919 UPDATE OXA-593 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3489 UPDATE OXA-404 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3488 UPDATE OXA-403 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4368 UPDATE BEL-4 penam; monobactam; cephalosporin; antibiotic inactivation; BEL beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3481 UPDATE OXA-364 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3480 UPDATE OXA-346 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3483 UPDATE OXA-373 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3482 UPDATE OXA-372 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3485 UPDATE OXA-392 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3487 UPDATE OXA-401 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3486 UPDATE OXA-400 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 929 UPDATE GES-10 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ820124.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 3649 UPDATE Neisseria gonorrhoeae mtrR with mutation conferring resistance antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; azithromycin; erythromycin; ARO_description; model_sequences; model_name "UPDATED ARO_description with MtrR is a repressor of mtrCDE efflux pump expression, point mutations in mtrR confer resistance to azithromycin and other drugs. UPDATED partial with 0 UPDATED sequence with ATGAGAAAAACCAAAACCGAAGCCTTGAAAACCAAAGAACACCTGATGCTTGCCGCCTTGGAAACCTTTTACCGCAAAGGGATTGCCCGCACCTCGCTCAACGAAATCGCCCAAGCCGCCGGCGTAACGCGCGGCGCGCTCTATTGGCATTTCAAAAATAAGGAAGACTTGTTTGACGCGTTGTTCCAACGTATCTGCGACGACATCGAAAACTGCATCGCGCAAGATGCCGCAGATGCCGAAGGAGGTTCTTGGACGGTATTCCGCCACACGCTGCTGCACTTTTTCGAGCGGCTGCAAAGCAACGACATCTACTACAAATTCCACAACATCCTGTTTTTAAAATGCGAACACACGGAGCAAAACGCCGCCGTTATCGCCATTGCCCGCAAGCATCAGGCAATCTGGCGCGAGAAAATTACCGCCGTTTTGACCGAAGCGGTGGAAAATCAGGATTTGGCTGACGATTTGGACAAGGAAACGGCGGTCATCTTCATCAAATCGACGTTGGACGGGCTGATTTGGCGTTGGTTCTCTTCCGGCGAAAGTTTCGATTTGGGCAAAACCGCCCCGCGCATCATCGGGATAATGATGGACAACTTGGAAAACCATCCCTGCCTGCGCCGGAAATAA UPDATED fmax with 1333499 UPDATED accession with CP001050.1 UPDATED fmin with 1332866 UPDATED strand with + UPDATED NCBI_taxonomy_name with Neisseria gonorrhoeae NCCP11945 UPDATED NCBI_taxonomy_id with 521006 UPDATED NCBI_taxonomy_cvterm_id with 37080 UPDATED accession with ACF30254.1 UPDATED sequence with MRKTKTEALKTKEHLMLAALETFYRKGIARTSLNEIAQAAGVTRGALYWHFKNKEDLFDALFQRICDDIENCIAQDAADAEGGSWTVFRHTLLHFFERLQSNDIYYKFHNILFLKCEHTEQNAAVIAIARKHQAIWREKITAVLTEAVENQDLADDLDKETAVIFIKSTLDGLIWRWFSSGESFDLGKTAPRIIGIMMDNLENHPCLRRK UPDATED model_name with Neisseria gonorrhoeae mtrR with mutation conferring resistance " 3646 UPDATE Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; azithromycin; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutation in the 23S rRNA of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. UPDATED accession with NR_103957.1 UPDATED model_name with Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin " 3645 UPDATE LEN-58 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with A class-A broad-spectrum beta-lactamase from Klebsiella. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3644 UPDATE LEN-55 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with A class-A broad-spectrum beta-lactamase from Klebsiella. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3643 UPDATE LEN-51 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with A class-A broad-spectrum beta-lactamase from Klebsiella. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3642 UPDATE LEN-43 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with A class-A broad-spectrum beta-lactamase from Klebsiella. UPDATED NCBI_taxonomy_name with Klebsiella variicola subsp. tropica UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3641 UPDATE LEN-42 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with A class-A broad-spectrum beta-lactamase from Klebsiella. UPDATED NCBI_taxonomy_name with Klebsiella variicola subsp. tropica UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3640 UPDATE LEN-41 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with A class-A broad-spectrum beta-lactamase identified from Klebsiella. UPDATED NCBI_taxonomy_name with Klebsiella variicola subsp. tropica UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2551 UPDATE glycopeptide resistance gene cluster VanI glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX. " 986 UPDATE baeS antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; aminocoumarin antibiotic; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; aminoglycoside antibiotic; model_sequences "UPDATED accession with AP009048.1 " 61 UPDATE OXA-330 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203104.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2396 UPDATE OXA-368 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2397 UPDATE pgpB peptide antibiotic; polymyxin B1; lipid A phosphatase; polymyxin B2; polymyxin B3; polymyxin B4; antibiotic target alteration; ARO_description "UPDATED ARO_description with A gene that produces the protein lipid A 4'-phosphatase. " 2398 UPDATE TEM-220 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 65 UPDATE GES-21 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ772478.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 2778 UPDATE MCR-2.1 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; model_name "UPDATED model_name with MCR-2.1 " 2779 UPDATE FosA6 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; ARO_description "UPDATED ARO_description with FosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. " 4899 UPDATE OXA-572 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4898 UPDATE OXA-569 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5014 UPDATE OXA-702 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5015 UPDATE OXA-703 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5016 UPDATE OXA-704 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5017 UPDATE OXA-705 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2771 UPDATE QepA2 antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; ciprofloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_sequences "UPDATED ARO_description with QepA2 is a plasmid-mediated quinolone resistance pump found in an Escherichia coli isolate from France. UPDATED partial with 0 UPDATED sequence with ATGTCCGCCACGCTCCACGACACCGCAGCGGATCGTCGGAAGGCCACCCGCCGCGAATGGATCGGCCTGGCCGTGGTCGCCCTGCCGTGCCTGGTCTACGCCATGGACCTCACGGTGCTGAACCTGGCGCTGCCGGTGCTCAGCCGTGAACTGCAGCCCTCCAGCGCCCAGCTTCTCTGGATCCTGGACATCTACGGCTTCTTCGTCGCCGGCTTCCTGATCACCATGGGCACGCTGGGCGACCGCATCGGCCGGCGCCGGCTGTTGTTGATCGGCGCGGCGTTCTTCGCATTCGGCTCGGTGCTCGCGGCGCTGGCCGATACCGCCGCGCTGTTGATCGCGGCGCGCGCCTTGCTCGGCCTGGCCGGCGCCACCATCGCGCCGTCCACCATGGCGCTGATCCGCAACATGTTCCACGACCCGCGCCAGCGCCAGTTCGCCATCGGCGTGTGGATCGCCGCGTTTTCGCTGGGCAGCGCGATCGGTCCGCTGGTCGGCGGCGTGTTGCTGGAGTTCTTCCACTGGGGCGCCGTGTTCTGGCTCAACGTGCCGGTGATGCTGCTGACGCTGGCGCTCGGCCCTCGCTTCCTGCCCGAGTATCGTGATCCGGACGCGGGGCACCTGGACCTGGCCAGCGTGCTGCTGTCGCTGGCGGCGGTGCTGCTGACGATCTACGGGCTCAAGCAGTTGGCCGAGCATGGAGCGGGCCTCGCCTCGATGGCTGCGCTGCTGGCCGGGCTGGCGGTCGGGGCGCTGTTCCTGCGCCGCCAGGGCCACATCGCCTACCCGCTGCTGGACCTGCGGCTGTTCGCGCACGCGCCGTTCCGCGCGGCGCTGGCGGCGTATGCGCTGGCCGCGCTGGCCATGTTCGGCGTCTACATCTTCATGACGCAGTACCTGCAGCTCGTGCTGGGGCTGTCGCCGCTGCAGGCCGGGCTGGCCACGCTGCCCTGGTCCCTGTGCTTCGTCATCGGTTCGCTGTTGTCGCCGCAGCTCGCGGCGCGCTGGCCGGCGGCGCGCATCCTCGTCGTGGGCCTGTCGGCAGCGGCGTTCGGCTTCGCCGTGCTGGGGCTGGGGCAGGGCCTGTGGTGGCTGGTGCCGGCCACGATCGTCATGGGCCTGGGCCTGGCGCCGGTGTTCACCATCGGCAACGAGATCATCATCACCAGCGCGCCGTCCGAGCGCGCGGGCGCGGCCTCGGCCTTGTCGGAGACGGTGTCCGAATTCAGCGGCGCGCTGGGCATCGCGCTGTTCGGCAGCGTCGGCCTGGTGGTCTACCGGCAGGCGCTGACCAGCGCGGCGCTGCCCGGCCTGCCGGCCGATGCGCTGCAGGCGGCCGGTGCCTCGCTCGGGGGCGCCGTGCACCTGGCCGACACCCTGCCGGCGTGGCAGGGCGCGGCCTTGCTGGCGGCCGCACGCGCGGGCTTCACCGATGCGCTGCAGGCCACGGCCTGGGCCGGCGCGGTGCTGGTGCTGGTGGCCGCTGGGCTGGTGGCGCGCCTGCTGCGCAAGCGCCCAGCGCTCGCATCTGGTTGA UPDATED fmax with 3207 UPDATED accession with EU847537.1 UPDATED fmin with 1671 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ACF70723.1 UPDATED sequence with MSATLHDTAADRRKATRREWIGLAVVALPCLVYAMDLTVLNLALPVLSRELQPSSAQLLWILDIYGFFVAGFLITMGTLGDRIGRRRLLLIGAAFFAFGSVLAALADTAALLIAARALLGLAGATIAPSTMALIRNMFHDPRQRQFAIGVWIAAFSLGSAIGPLVGGVLLEFFHWGAVFWLNVPVMLLTLALGPRFLPEYRDPDAGHLDLASVLLSLAAVLLTIYGLKQLAEHGAGLASMAALLAGLAVGALFLRRQGHIAYPLLDLRLFAHAPFRAALAAYALAALAMFGVYIFMTQYLQLVLGLSPLQAGLATLPWSLCFVIGSLLSPQLAARWPAARILVVGLSAAAFGFAVLGLGQGLWWLVPATIVMGLGLAPVFTIGNEIIITSAPSERAGAASALSETVSEFSGALGIALFGSVGLVVYRQALTSAALPGLPADALQAAGASLGGAVHLADTLPAWQGAALLAAARAGFTDALQATAWAGAVLVLVAAGLVARLLRKRPALASG " 4891 UPDATE OXA-562 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4890 UPDATE OXA-561 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2774 UPDATE TMB-2 antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; cephamycin; TMB beta-lactamase; model_sequences "UPDATED accession with AB758278.1 " 2775 UPDATE Pseudomonas aeruginosa soxR antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; tigecycline; protein(s) and two-component regulatory system modulating antibiotic efflux; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 4895 UPDATE OXA-566 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4894 UPDATE OXA-565 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3307 UPDATE Escherichia coli ampH beta-lactamase penam; antibiotic inactivation; cephalosporin; ampC-type beta-lactamase; ARO_category; model_name "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with Escherichia coli ampH beta-lactamase " 3940 UPDATE CMY-130 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KP207589.1 " 312 UPDATE OXA-167 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM488988.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1858 UPDATE OXA-387 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ173478.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1859 UPDATE QnrVC7 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; model_sequences; ARO_category "UPDATED accession with KM555152.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4419 UPDATE CARB-33 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4418 UPDATE CARB-32 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1850 UPDATE FomB fosfomycin; antibiotic inactivation; Fom phosphotransferase family; model_sequences "UPDATED accession with AB016934.1 " 4416 UPDATE CARB-30 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1852 UPDATE rmtF antibiotic target alteration; aminoglycoside antibiotic; 16S rRNA methyltransferase (G1405); model_sequences "UPDATED accession with JQ808129.1 " 1853 UPDATE OXA-20 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-20 is a beta-lactamase found in P. aeruginosa. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1854 UPDATE rmtA kanamycin A; aminoglycoside antibiotic; isepamicin; 16S rRNA methyltransferase (G1405); sisomicin; arbekacin; gentamicin B; netilmicin; antibiotic target alteration; gentamicin C; amikacin; dibekacin; G418; tobramycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAGCTTTGACGATGCCCTAGCGTCCATCCTTTCCTCAAAAAAATATCGTTCCCTCTGCCCGGATACCGTACGGCGGATTTTAGATCAGGAATGGGGGCGGCACAAATCGCCTAAGCTGGCAGTGGAGGCCACTCGCACCCGGCTGCACGGGATTTGCGGGGCCTATGTCACGCCGGAATCGCTCAAGGCTGCAGCAGCGGCATTATCGGTTGGCGATGTGCAAAAGGCACTGTCGCTGCACGCCTCTACCAAGGAGCGGTTGGCCGAATTGGACTGCCTCTACGATTTTATCTTTTCTGGCGGGGTGCCCCATCGTGTGTTGGATATCGCTTGCGGCCTAAACCCGCTGGCCCTCTTTATACGTGACATAACATCTGTATGGGCGTGCGACATCCATCAGGGGTTGGGCGATGTGATCACCCCCTTTGCCCATCATCAGGGATTGGACTTCACGTTCGCCCTGCAGGATGTGATGTGTACGCCGCCCACTGAGACGGGGGATTTGGCACTGGTATTTAAATTACTGCCTTTGCTGGAGCGAGAGCAAGCTGGCGCCGCCATGGCGCTACTGCAGGCACTAGCTACCCCTCGGATTGCCGTCAGCTTCCCCACCCGCAGTTTAGGCGGGCGCGGCAAGGGCATGGAAGCAAACTATTCCGCATGGTTCGAGGGGGCACTGCCTGATGAATTTGAAATTGAGGATACCAAGACCATTGGAATAGAGCTTGTGTACATGATAAAAAGGAATAAGTGA UPDATED fmax with 6237 UPDATED accession with AB083212.2 UPDATED fmin with 5481 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with BAC20579.1 UPDATED sequence with MSFDDALASILSSKKYRSLCPDTVRRILDQEWGRHKSPKLAVEATRTRLHGICGAYVTPESLKAAAAALSVGDVQKALSLHASTKERLAELDCLYDFIFSGGVPHRVLDIACGLNPLALFIRDITSVWACDIHQGLGDVITPFAHHQGLDFTFALQDVMCTPPTETGDLALVFKLLPLLEREQAGAAMALLQALATPRIAVSFPTRSLGGRGKGMEANYSAWFEGALPDEFEIEDTKTIGIELVYMIKRNK " 4412 UPDATE CARB-26 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1856 UPDATE QnrB20 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB20 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED accession with AB379831.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1857 UPDATE VIM-9 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY524988.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 919 UPDATE PER-1 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_description; ARO_category "UPDATED ARO_description with PER-1 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 918 UPDATE TEM-49 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y10281.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4969 UPDATE OXA-644 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4968 UPDATE OXA-643 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 915 UPDATE SHV-106 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM941847.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 914 UPDATE ANT(6)-Ia antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); ARO_description; ARO_category "UPDATED ARO_description with ANT(6)-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Staphylococcus epidermidis, E. faecium, Streptococcus suis, S. aureus, E. faecalis and Streptococcus mitis. UPDATED category_aro_description with Nucelotidylylation of streptomycin at the hydroxyl group at position 6. " 2178 UPDATE glycopeptide resistance gene cluster VanO glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Homologous to vanA, contains a D-Ala-D-Lac ligase. The chromosome-located vanO gene cluster is inducible. Not much is known about the biochemistry about the vanO gene cluster. Gene orientation: orf1 RS orf2 HOX. " 4964 UPDATE OXA-638 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 911 UPDATE CMY-50 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with FN645444.1 " 910 UPDATE rphA antibiotic inactivation; rifampin; rifapentine; rifampin phosphotransferase; rifabutin; rifaximin; rifamycin antibiotic; model_sequences "UPDATED accession with KJ151292.1 " 913 UPDATE OXY-6-4 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-6-4 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ871877.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 912 UPDATE LEN-13 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1421 UPDATE TEM-85 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ277414.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1109 UPDATE CAU-1 carbapenem; penam; CAU beta-lactamase; antibiotic inactivation; ARO_description; model_sequences; model_name; ARO_category "UPDATED ARO_description with CAU-1 is a B3 metallo-beta-lactamase that is encoded by the Caulobacter crescentus chromosome. UPDATED accession with AJ308331.1 UPDATED model_name with CAU-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1423 UPDATE TEM-15 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM849805.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1933 UPDATE SHV-160 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121127.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1932 UPDATE IMP-32 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with JQ002629.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1931 UPDATE TEM-150 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM183304.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1589 UPDATE PER-3 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; model_sequences; ARO_category "UPDATED accession with AY740681.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5128 UPDATE OXA-826 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1935 UPDATE Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; fluoroquinolone resistant gyrA; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; model_sequences "UPDATED accession with AL123456.1 " 1934 UPDATE lnuD antibiotic inactivation; lincosamide nucleotidyltransferase (LNU); lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with lnuD is a plasmid-mediated nucleotidyltransferase found in Streptococcus uberis. UPDATED accession with EF452177.1 " 5124 UPDATE OXA-821 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3368 UPDATE emtA antibiotic target alteration; non-erm 23S ribosomal RNA methyltransferase (G748); macrolide antibiotic; lincosamide antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with A rRNA methyltransferase conferring high-level evernimicin resistance. UPDATED partial with 0 UPDATED sequence with ATGACTCTTTATTTTGCGAGCGTATTGTCTGGATTAGAATACGTTTTATCAAATGAAATTAACAACAAGGTGAGTGATTCTGAAATAATTCAAATAAATAGAGGGAAGGTTTTCTTTACCACAGCTGAGTCTTTTACATGCTTAAGTTCTTTAAGGTCAGCAGATCACTTGTTTCAAGTTATTGATCAATTTCAAATCGGTCCACATAAAAAGCACTTATCTCAGGTAAGCGAGCGAATATCCCAGTTGGATTTAGAATTTATTGATCATAAAGATTTATTTTGGGTAAATGCAAGCCGTAAAGGAAAACAAACCTATAGTCGCTTTGAATTAGCAAAAAAAGCAATGGAGGGTATTAATAAGCGTTACCCTGATTGGAACATTGGAACGTCTCAAAATCATCAGATAGAATTCAGACTCGACATTGAACATCATAATGTGATTTTTTCACTTCGGCTTACAGATGCGACGTTTCGTTTTCGAAATCAGACACGACGGTTCTCTCGTGCATCATTACTTCCTTCTGTGGCTCATGCGATGGTGTGGTTGTCAGATCCTGAATCGAAAGATGTTTTCGTAGACTTTTGTTGTGGTTCAGGCACAATTTTGTCTGAACGAGCCACATACCCTGCAAATCAGATAATTGGTGGAGATATATCTGAAGCAGTCACAAAGATAGCCAAAAGTAATCTCGATGATTCGAAGGTGCAAGTTAATGTTTGGGATGCACGGAAATTGCCTTTTTCTACTGGCTGTGTCGATAAAATTGTTACTAATCTTCCATTTGGAAGACAAATTTCCCCTGACGAGGACTTAGAATTGTTCAATCACCATATTATGATTGAAGTATGTAGAGTCTTGAAGCCAAATGGGAGAGCCGTTATTTTGTCTGAGAGTGTCAATCAATTGTTTTGGGAAGCAAAACGATTAGGCCTTTTTTGTCTGGAATCTTATCCTTTGAGTTTGAAGGGCGTGAATCCTACCTTGTTTGTGTTTGAAAAACAAGATGGACTTAGAAGGAAGTAG UPDATED fmax with 1685 UPDATED accession with AF403298.1 UPDATED fmin with 659 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterococcus faecium UPDATED NCBI_taxonomy_id with 1352 UPDATED NCBI_taxonomy_cvterm_id with 36779 UPDATED accession with AAL02176.1 UPDATED sequence with MTLYFASVLSGLEYVLSNEINNKVSDSEIIQINRGKVFFTTAESFTCLSSLRSADHLFQVIDQFQIGPHKKHLSQVSERISQLDLEFIDHKDLFWVNASRKGKQTYSRFELAKKAMEGINKRYPDWNIGTSQNHQIEFRLDIEHHNVIFSLRLTDATFRFRNQTRRFSRASLLPSVAHAMVWLSDPESKDVFVDFCCGSGTILSERATYPANQIIGGDISEAVTKIAKSNLDDSKVQVNVWDARKLPFSTGCVDKIVTNLPFGRQISPDEDLELFNHHIMIEVCRVLKPNGRAVILSESVNQLFWEAKRLGLFCLESYPLSLKGVNPTLFVFEKQDGLRRK UPDATED category_aro_description with Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides. " 1939 UPDATE AAC(6')-Ix AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; model_sequences "UPDATED accession with AF031332.1 " 1938 UPDATE mtrD penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; penicillin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5120 UPDATE OXA-816 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5121 UPDATE OXA-817 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5122 UPDATE OXA-819 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5123 UPDATE OXA-820 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 847 UPDATE CTX-M-108 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with GTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGCTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCAA UPDATED fmax with 864 UPDATED accession with JF274245.1 UPDATED fmin with 1 UPDATED strand with + UPDATED NCBI_taxonomy_name with Shigella sp. SH223 UPDATED NCBI_taxonomy_id with 1074434 UPDATED NCBI_taxonomy_cvterm_id with 39657 UPDATED accession with AEM44651.1 UPDATED sequence with VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRAEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT " 846 UPDATE DHA-12 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with HG798963.1 " 845 UPDATE TEM-163 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU815939.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 844 UPDATE CMY-117 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM087844.1 " 843 UPDATE QnrB14 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB14 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with EU273757.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 842 UPDATE ugd pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; ARO_description; model_sequences "UPDATED ARO_description with PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. UPDATED accession with U00096.1 " 3461 UPDATE OXA-299 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3460 UPDATE OXA-298 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1090 UPDATE TEM-169 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ873740.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 849 UPDATE OXA-138 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-138 is a beta-lactamase found in A. baumannii. UPDATED partial with 0 UPDATED sequence with ATGAACATTAAAACCCTCTTACTTATAACAAGCGCTATTTTTATTTCAGCCTGCTCACCTTATATAGTGACTGCTAATCCAAATCACAGCGCTTCAAAATCTGATGTAAAAGCAGAGAAAATTAAAAATTTATTTAACGAAGCACACACTACGGGTGTTTTAGTTATCCAACAAGGCCAAACTCAACAAAGCTATGGTAATGATCTTGCTCGTGCTTCGACCGAGTATGTACCTGCTTCGACCTTCAAAATGCTTAATGCTTTGATCGGCCTTGAGCACCATAAGGCAACCACCACAGAAGTATTTAAGTGGGATGGTAAAAAAAGGTTATTCCCAGAATGGGAAAAGGACATGACCCTAGGCGATGCCATGAAAGCTTCCGCTATTCCAGTTTATCAAGATTTAGCTCGTCGTATTGGACTTGAGCTCATGTCTAAGGAAGTGAAGCGTGTTGGTTATGGCAATGCAGATATCGGTACCCAAGTCGATAATTTTTGGGTGGTGGGTCCTTTAAAAATTACTCCTCAGCAAGAGGCACAGTTTGCTTACAAGCTAGCTAATAAAACGCTTCCATTTAGCCAAAAAGTCCAAGATGAAGTGCAATCCATGCTATTCATAGAAGAAAAGAATGGAAACAAAATATACGCAAAAAGTGGTTGGGGATGGGATGTAAACCCACAAGTAGGCTGGTTAACTGGATGGGTTGTTCAGCCTCAAGGGAATATTGTAGCGTTCTCCCTTAACTTAGAAATGAAAAAAGGAATACCTAGCTCTGTTCGAAAAGAGATTACTTATAAAAGCTTAGAACAATTAGGTATTTTATAG UPDATED fmax with 2419 UPDATED accession with EU670845.2 UPDATED fmin with 1594 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter nosocomialis UPDATED NCBI_taxonomy_id with 106654 UPDATED NCBI_taxonomy_cvterm_id with 36949 UPDATED accession with ACD45467.1 UPDATED sequence with MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 848 UPDATE OKP-A-2 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-2 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTTTCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTCGAGCAAGTTACACGCAGCGAAAGTCAGCTGGCGGGCCGCGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGAGACGAACAGCTGGATCGGCGGATCCGCTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTTGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAGCTCAATGAAGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCAGCCAGCATGGCCGCCACCCTGCGCAAGCTGCTAACCAGCCACACTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCAGGTAGCCGGTCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGCGAGCGGGGCTCACGTGGCATTGTCGCCCTGCTCGGCCCGAACGGCAAAGCGGAGCGCATCGTGGTGATCTATCTGCGGGATACGCCGGCGACCATGGCCGAGCGTAACCAGCAGATCGCCAGAATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAG UPDATED fmax with 861 UPDATED accession with AJ635404.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAG25815.2 UPDATED sequence with MRYVRLCLFSLIAALPLAVFASPQPLEQVTRSESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIRYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMAATLRKLLTSHTLSARSQQQLLQWMVDDQVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPNGKAERIVVIYLRDTPATMAERNQQIARIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 664 UPDATE CMY-43 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with FJ360626.1 " 1429 UPDATE SHV-60 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB302939.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1583 UPDATE QnrVC6 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrVC6 is an integron-mediated quinolone resistance protein found in Acinetobacter baumannii. UPDATED accession with KC202804.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 459 UPDATE CTX-M-94 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-94 is a beta-lactamase found in Escherichia coli. UPDATED accession with HM167760.1 " 2377 UPDATE Escherichia coli PtsI with mutation conferring resistance to fosfomycin fosfomycin; antibiotic-resistant ptsI phosphotransferase; antibiotic target alteration; model_sequences "UPDATED accession with HG738867.1 UPDATED accession with CDJ72759.1 " 1069 UPDATE IMP-35 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-35 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with JF816544.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4394 UPDATE BlaB-32 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1587 UPDATE OXA-10 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF205943.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1585 UPDATE CMY-73 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with GQ351345.1 " 1739 UPDATE SHV-16 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCACTCATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTACTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 993 UPDATED accession with AF072684.2 UPDATED fmin with 117 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAC98092.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKITHRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1738 UPDATE CTX-M-45 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-45 is a beta-lactamase found in Escherichia coli. UPDATED accession with D89862.1 " 2179 UPDATE glycopeptide resistance gene cluster VanE glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanE gene cluster is inducible and confers low resistance to vancomycin. vanE organisms remain susceptible to teicoplanin. Gene orientation: E(XY)TRS. " 1068 UPDATE AAC(6')-Ib3 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with FJ854362.1 " 1730 UPDATE OXA-235 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-235 is a beta-lactamase found in A. baumannii. UPDATED partial with 0 UPDATED sequence with ATGAAAACTCTTATTTTGTTGCCTTTACTTAGTTGCTTGAGCCTGACAGCCTGTAGCTTGCCTGTTTCAAATTCGTCCTCTCAAATCACTTCAACTCAATCTATTCAAACCATTGCCAAATTATTTGATCAGGCACAAAGCTCTGGCGTTTTAGTAATTCAACGGGGCCCACATCTACAGGTCTATGGCAATGATTTGAGTCGTGCACATACCGAATATATTCCTGCTTCAACCTTTAAAATACTCAATGCCCTGATTGGCCTGCAACATGGTAAAGCCACGACCAATGAAATCTTTAAATGGGATGGCAAGAAGCGCAGTTTTGCAGCCTGGGAAAAAGACATGACTCTCGGCCAAGCCATGCAAGCTTCTGCTGTACCCGTCTATCAGGAACTGGCACGTCGCATTGGTCTGGAACTAATGCAACAGGAAGTGCAACGCATTCGATTTGGTAATCAGCAGATTGGTCAGCATATCGACAACTTCTGGTTAGTCGGACCTTTGAAAATCACCCCGGAACAAGAAGTCGAATTTGCCTCTGCGCTTGCTCAAGAGCAACTTGCCTTTGATCCTCAAGTCCAGCAACAAGTCAAAGCCATGTTACTGTTACAGGAGCGACAAGATTATCGACTATATGCCAAATCTGGTTGGGGTATGGATGTGGAGCCGCAAGTCGGCTGGCTCACCGGCTGGATCGAAACACCTCAGGACGAAATCGTGGCATTTTCACTGAATATGCAGATGCAAAGTAATATGGATCCGGCGATCCGTCTTAAAATTTTGCAGCAGGCCTTGGCCGAATTAGCGCTTTATCCGAAAGCTGAAGGGTAA UPDATED fmax with 1421 UPDATED accession with JQ820240.2 UPDATED fmin with 590 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with AFH36330.1 UPDATED sequence with MKTLILLPLLSCLSLTACSLPVSNSSSQITSTQSIQTIAKLFDQAQSSGVLVIQRGPHLQVYGNDLSRAHTEYIPASTFKILNALIGLQHGKATTNEIFKWDGKKRSFAAWEKDMTLGQAMQASAVPVYQELARRIGLELMQQEVQRIRFGNQQIGQHIDNFWLVGPLKITPEQEVEFASALAQEQLAFDPQVQQQVKAMLLLQERQDYRLYAKSGWGMDVEPQVGWLTGWIETPQDEIVAFSLNMQMQSNMDPAIRLKILQQALAELALYPKAEG UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1733 UPDATE OXA-415 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-415 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. UPDATED accession with KJ865754.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1732 UPDATE SHV-151 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121118.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5234 UPDATE OXY-2-11 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1734 UPDATE IND-4 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-4 is a beta-lactamase found in Chryseobacterium indologenes. UPDATED partial with 0 UPDATED sequence with ATGAGGAAAAATGTTAGGATTTTTACTGTGTTGTCTCTGTTCTTAATTAATTTTTTTAATGCGCAGGCCCGTGACTTTGTAATTGAGCAGCCTTTTGGCAAACAACTTTATCTGTATAAAACCTTCGGAGTTTTTGACGGCAAAGAATATTCAACCAATGCGCTTTATCTGGTCACTAAAAAAGGAGTAGTCCTTTTTGATGTCCCATGGCAGAAAACCCAGTATCAAAGTCTTATGGATACGATAAAGAAACGTCATAACTTACCGGTGATCGCTGTATTTGCAACACATTCACACTCAGACAGAGCCGGAGACCTGAGTTTTTACAATAAAAAAGGCATCCCGACCTATGCCACGGCCAAAACCAATGAACTGCTGAAGAAAGAAGGAAAAGCAACTTCCAGTAAATTAACAAAGATTGGAAAGAAATATAAAATAGGCGGTGAAGAATTCACTGTAGACTTCTTAGGTGAAGGTCACACAGCAGATAACGTGGTGGTTTGGTTTCCAAAATATAACGTCCTGGACGGTGGCTGCTTAGTGAAAAGCAGTGCAGCAGTTGATCTTGGATATACAGGAGAAGCTAATGTAGAACAATGGCCGGCAACCATGAAAAAGCTGCAGGCTAAATACCCCTCCACTGCAAAGGTAATTCCGGGACACGACGAGTGGAAAGGCAACGACCATGTAAAACATACACTGGAGCTTTTAGATCAACAAAAACAGTAG UPDATED fmax with 729 UPDATED accession with AF219135.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Chryseobacterium indologenes UPDATED NCBI_taxonomy_id with 253 UPDATED NCBI_taxonomy_cvterm_id with 36916 UPDATED accession with AAG29765.2 UPDATED sequence with MRKNVRIFTVLSLFLINFFNAQARDFVIEQPFGKQLYLYKTFGVFDGKEYSTNALYLVTKKGVVLFDVPWQKTQYQSLMDTIKKRHNLPVIAVFATHSHSDRAGDLSFYNKKGIPTYATAKTNELLKKEGKATSSKLTKIGKKYKIGGEEFTVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSSAAVDLGYTGEANVEQWPATMKKLQAKYPSTAKVIPGHDEWKGNDHVKHTLELLDQQKQ UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 1737 UPDATE ANT(4')-Ia antibiotic inactivation; aminoglycoside antibiotic; ribostamycin; plazomicin; paromomycin; kanamycin A; gentamicin B; lividomycin B; ANT(4'); lividomycin A; isepamicin; G418; neomycin; tobramycin; model_sequences; ARO_category "UPDATED accession with EF540343.1 UPDATED NCBI_taxonomy_name with Alkalihalobacillus clausii UPDATED category_aro_description with Nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 4'. " 1736 UPDATE GES-24 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB901141.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1039 UPDATE dfrB3 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrB3 is an integron-encoded dihydrofolate reductase found in Klebsiella oxytoca. UPDATED accession with GQ150744.1 " 1184 UPDATE OXA-182 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAAAAAATTTATACTTCCTATCTTCAGCATTTCTATTCTACTTTCTCTCAGTGCATGCTCATCTATTCAAACTAAATTTGAAGATACTTTTCATATTTCTAATCAGAAACATGAAAAAGCTATTAAAAGCTATTTTGATGAAGCTCAAACACAAGGTGTAATTATTATTAAGGAAGGTAAAAATATTAGCTCCTATGGTAATAACCTTGTACGAGCACATACAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCTTTAATCGGACTAGAAAATCATAAAGCGACAACAAATGAGATTTTTAAATGGGATGGTAAAAAAAGATCTTATCCTATGTGGGAGAAAGATATGACTTTGGGTGAGGCCATGGCACTTTCAGCTGTTCCTGTATATCAAGATCTTGCGAGACGGATTGGCTTAAATCTCATGCAAAAAGAAGTTAAACGCGTTGGTTTTGGTAATATGAACATTGGAACACAAGTTGATAATTTCTGGTTGATTGGTCCTCTTAAGATTACACCAATACAAGAAGTGAATTTTGCCGATGATCTTGCGAATAATCGATTACCCTTTAAATTAGAAACTCAAGAAGAAGTAAAAAAGATGCTTCTGATTAAAGAAGTCAATGGTAGTAAAATTTATGCTAAAAGCGGATGGGGAATGGATGTAAGCCCACAAGTAGGTTGGTTAACAGGTTGGGTAGAAAAATCTAATGGAGAAAAAGTTTCCTTTTCTTTAAATATAGAAATGAAGCAAGGAATGTCTGGTTCTATTCGTAATGAGATTACTTATAAGTCGTTAGAAAATTTAGGGATCATCTAA UPDATED fmax with 828 UPDATED accession with HM640278.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with ADK92148.1 UPDATED sequence with MKKFILPIFSISILLSLSACSSIQTKFEDTFHISNQKHEKAIKSYFDEAQTQGVIIIKEGKNISSYGNNLVRAHTEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRSYPMWEKDMTLGEAMALSAVPVYQDLARRIGLNLMQKEVKRVGFGNMNIGTQVDNFWLIGPLKITPIQEVNFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVSPQVGWLTGWVEKSNGEKVSFSLNIEMKQGMSGSIRNEITYKSLENLGII UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 753 UPDATE SMB-1 SMB beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; penam; model_sequences; model_name; ARO_category "UPDATED accession with AB636283.1 UPDATED model_name with SMB-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 751 UPDATE TEM-217 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with From the Lahey list of beta-lactamases. Not yet released. Isolated from Enterobacter cloacae. UPDATED accession with HG934763.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 750 UPDATE SHV-172 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF513177.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 757 UPDATE CMY-80 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ733577.1 " 756 UPDATE Enterococcus faecium liaR mutant conferring daptomycin resistance antibiotic efflux; protein(s) and two-component regulatory system modulating antibiotic efflux; peptide antibiotic; daptomycin resistant liaR; antibiotic target alteration; daptomycin; model_sequences "UPDATED accession with CP003583.1 " 755 UPDATE KPC-9 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with KPC-9 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with FJ624872.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3783 UPDATE YajC penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 759 UPDATE OCH-2 penam; antibiotic inactivation; penem; cephalosporin; cephamycin; monobactam; OCH beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OCH-2 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. UPDATED accession with AJ295340.1 UPDATED NCBI_taxonomy_name with Brucella anthropi UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. " 509 UPDATE FOX-1 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with FOX-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with X77455.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 1595 UPDATE mecB penam; methicillin resistant PBP2; antibiotic target replacement; model_sequences; ARO_category "UPDATED accession with AB498758.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 506 UPDATE IMP-5 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-5 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with AF290912.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3322 UPDATE AAC(3)-IId antibiotic inactivation; AAC(3); aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. " 3781 UPDATE PDC-65 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-65 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. " 1591 UPDATE CMY-64 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with HQ832678.1 " 1590 UPDATE QnrB27 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB27 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. UPDATED accession with HM439641.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 507 UPDATE rosB antibiotic efflux; polymyxin B1; major facilitator superfamily (MFS) antibiotic efflux pump; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; polymyxin B2; polymyxin B3; polymyxin B4; model_sequences "UPDATED accession with U46859.1 " 1599 UPDATE SHV-23 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF117747.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1598 UPDATE OXA-101 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM412777.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3787 UPDATE OmpA penam; reduced permeability to antibiotic; penem; carbapenem; cephalosporin; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1025 UPDATE TEM-136 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY826417.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1024 UPDATE AAC(6')-Ib-SK AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ib-SK is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces kanamyceticus. UPDATED accession with AB164230.1 " 1027 UPDATE tet(H) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with Y15510.1 " 1031 UPDATE APH(6)-Id antibiotic inactivation; APH(6); streptomycin; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum. UPDATED accession with AF024602.1 UPDATED category_aro_description with Phosphorylation of streptomycin on the hydroxyl group at position 6. " 1021 UPDATE CTX-M-54 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-54 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCAGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGACTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA UPDATED fmax with 3050 UPDATED accession with DQ303459.3 UPDATED fmin with 2174 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with ABC18328.3 UPDATED sequence with MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEQTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL " 1020 UPDATE OXA-241 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-241 is a beta-lactamase found in A. baumannii. UPDATED accession with JX025021.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1023 UPDATE IMP-14 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with AY553332.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1022 UPDATE TEM-28 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with U37195.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1036 UPDATE vanWB glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanW; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanWB, is a vanW variant found in the vanB gene cluster. UPDATED accession with U35369.1 UPDATED model_name with vanW gene in vanB cluster UPDATED ARO_name with vanW gene in vanB cluster " 1029 UPDATE CMY-102 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KF526115.1 " 1028 UPDATE SHV-1 antibiotic inactivation; penam; carbapenem; cephalosporin; ampicillin; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ668814.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1037 UPDATE cmlA1 antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmlA1 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa and Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with GTGAGCTCAAAAAACTTTAGTTGGCGGTACTCCCTTGCCGCCACGGTGTTGTTGTTATCACCGTTCGATTTATTGGCATCACTCGGCATGGACATGTACTTGCCAGCAGTGCCGTTTATGCCAAACGCGCTTGGTACGACAGCGAGCACAATTCAGCTTACGCTGACAACGTACTTGGTCATGATTGGTGCCGGTCAGCTCTTGTTTGGACCGCTATCGGACCGACTGGGGCGCCGCCCCGTTCTACTGGGAGGTGGCCTCGCCTACGTTGTGGCGTCAATGGGCCTCGCTCTTACGTCATCGGCTGAAGTCTTTCTGGGGCTTCGGATTCTTCAGGCTTGTGGTGCCTCGGCGTGCCTTGTTTCCACATTTGCAACAGTACGTGACATTTACGCAGGTCGCGAGGAAAGTAATGTCATTTACGGCATACTCGGATCCATGCTGGCCATGGTCCCGGCGGTAGGCCCATTGCTCGGAGCGCTCGTCGACATGTGGCTTGGGTGGCGGGCTATCTTTGCGTTTCTAGGTTTGGGCATGATCGCTGCATCTGCAGCAGCGTGGCGATTCTGGCCTGAAACCCGGGTGCAACGAGTTGCGGGCTTGCAATGGTCGCAGCTGCTACTCCCCGTTAAGTGCCTGAACTTCTGGTTGTACACGTTGTGTTACGCCGCTGGAATGGGTAGCTTCTTCGTCTTTTTCTCCATTGCGCCCGGACTAATGATGGGCAGGCAAGGTGTGTCTCAGCTTGGCTTCAGCCTGCTGTTCGCCACAGTGGCAATTGCCATGGTGTTTACGGCTCGTTTTATGGGGCGTGTGATACCCAAGTGGGGCAGCCCAAGTGTCTTGCGAATGGGAATGGGATGCCTGATAGCTGGAGCAGTATTGCTTGCCATCACCGAAATATGGGCTTTGCAGTCCGTGTTAGGCTTTATTGCTCCAATGTGGCTAGTGGGTATTGGTGTCGCCACAGCGGTATCTGTGGCGCCCAATGGCGCTCTTCGAGGATTCGACCATGTTGCTGGAACGGTCACGGCAGTCTACTTCTGCTTGGGCGGTGTACTGCTAGGAAGCATCGGAACGTTGATCATTTCGCTGTTGCCGCGCAACACGGCTTGGCCGGTTGTCGTGTACTGTTTGACCCTTGCAACAGTCGTGCTCGGTCTGTCTTGTGTTTCCCGAGTGAAGGGCTCTCGCGGCCAGGGGGAGCATGATGTGGTCGCGCTACAAAGTGCGGGAAGTACATCAAATCCCAATCGTTGA UPDATED fmax with 1860 UPDATED accession with M64556.1 UPDATED fmin with 600 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AAA26057.1 UPDATED sequence with MSSKNFSWRYSLAATVLLLSPFDLLASLGMDMYLPAVPFMPNALGTTASTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLGGGLAYVVASMGLALTSSAEVFLGLRILQACGASACLVSTFATVRDIYAGREESNVIYGILGSMLAMVPAVGPLLGALVDMWLGWRAIFAFLGLGMIAASAAAWRFWPETRVQRVAGLQWSQLLLPVKCLNFWLYTLCYAAGMGSFFVFFSIAPGLMMGRQGVSQLGFSLLFATVAIAMVFTARFMGRVIPKWGSPSVLRMGMGCLIAGAVLLAITEIWALQSVLGFIAPMWLVGIGVATAVSVAPNGALRGFDHVAGTVTAVYFCLGGVLLGSIGTLIISLLPRNTAWPVVVYCLTLATVVLGLSCVSRVKGSRGQGEHDVVALQSAGSTSNPNR " 3136 UPDATE MCR-3.9 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with An MCR-3 polymyxin (incl. colistin) resistance gene variant isolated from an Aeromonas isolate. " 1034 UPDATE QnrA7 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrA7 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. UPDATED partial with 0 UPDATED sequence with ATGGATATTATTGATAAAGTTTTTCAGCAAGAGGATTTCTCACGCCAGGATTTGAGCGACAGCCGTTTTCGCCGCTGCCGCTTTTATCAGTGTGACTTCAGCCATTGCCAGCTAAGGGATGCCAGTTTCGAGGATTGCAGTTTCATTGAAAGCGGCGCCGTCGAAGGGTGCCACTTCAGCTATGCCGATCTGCGCGATGCCAGTTTCAAGGCCTGCCGCCTGTCTTTGGCCAATTTCAGCGGTGCCAACTGCTTTGGCATAGAGTTCAGGGAGTGCGATCTCAAGGGCGCCAATTTTTCCCGGGCCCGTTTTTACAATCAAATCAGCCATAAGATGTACTTCTGCTCGGCTTATATCTCAGGCTGTAACCTGGCCTATGCCAATTTGAGCGGCCAATGCCTGGAAAAGTGCGAGCTGTTTGAAAACAACTGGAGCAATGCCAACCTCAGCGGCGCTTCCTTGATGGGCTCCGACCTCAGCCACGGCACCTTCTCCCGCGACTGCTGGCAACAGGTAAACCTGCGGGGCTGTGACCTGACCTTTGCCGATCTGGATGGGCTCGACCCCAGACGGGTCAACCTCGAAGGGGTCAAGATCTGTGCCTGGCAGCAGGAGCAACTGCTGGAACCCTTGGGAGTCATAGTGCTGCCGGATTAG UPDATED fmax with 657 UPDATED accession with GQ463707.3 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Shewanella algae UPDATED NCBI_taxonomy_id with 38313 UPDATED NCBI_taxonomy_cvterm_id with 36891 UPDATED accession with ACV83303.2 UPDATED sequence with MDIIDKVFQQEDFSRQDLSDSRFRRCRFYQCDFSHCQLRDASFEDCSFIESGAVEGCHFSYADLRDASFKACRLSLANFSGANCFGIEFRECDLKGANFSRARFYNQISHKMYFCSAYISGCNLAYANLSGQCLEKCELFENNWSNANLSGASLMGSDLSHGTFSRDCWQQVNLRGCDLTFADLDGLDPRRVNLEGVKICAWQQEQLLEPLGVIVLPD UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1035 UPDATE Streptococcus pneumoniae PBP2b conferring resistance to amoxicillin penam; cephamycin; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; amoxicillin; ARO_description; ARO_category "UPDATED ARO_description with PBP2b is a penicillin-binding protein found in Streptococcus pneumoniae. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. " 605 UPDATE OXA-96 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-96 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ519090.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 604 UPDATE OXA-385 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF986253.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 606 UPDATE IMI-2 carbapenem; antibiotic inactivation; IMI beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with IMI-2 is a beta-lactamase found in Enterobacteriaceae. UPDATED accession with DQ173429.1 " 601 UPDATE dfrA20 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA20 is a plasmid-encoded dihydrofolate reductase found in Pasteurella multocida. UPDATED accession with AJ605332.1 " 1208 UPDATE SHV-173 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF513178.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4362 UPDATE ANA-1 carbapenem; ANA beta-lactamase; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1205 UPDATE VIM-39 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF131539.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1207 UPDATE DHA-13 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087855.1 " 1206 UPDATE QepA1 antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; ciprofloxacin; fluoroquinolone antibiotic; model_sequences; model_name "UPDATED accession with JQ064560.1 UPDATED model_name with QepA1 " 1201 UPDATE CARB-22 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 608 UPDATE OXA-361 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF460531.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1203 UPDATE Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid isoniazid; antibiotic target alteration; antibiotic resistant ndh; model_name "UPDATED model_name with Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid " 1202 UPDATE CTX-M-28 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-28 is a beta-lactamase found in Salmonella enterica. UPDATED accession with AJ549244.1 " 5649 UPDATE SGM-6 carbapenem; antibiotic inactivation; SGM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5648 UPDATE SGM-5 carbapenem; antibiotic inactivation; SGM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1211 UPDATE VIM-1 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF317511.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5645 UPDATE SGM-2 carbapenem; antibiotic inactivation; SGM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5644 UPDATE SGM-1 carbapenem; antibiotic inactivation; SGM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5647 UPDATE SGM-4 carbapenem; antibiotic inactivation; SGM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1214 UPDATE TEM-134 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY574271.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1944 UPDATE CTX-M-148 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KJ020574.1 " 1215 UPDATE FosC fosfomycin; antibiotic inactivation; fosC phosphotransferase family; ARO_description; model_sequences "UPDATED ARO_description with FosC is an enzyme that phosphorylates fosfomycin to confer resistance. UPDATED accession with Z33413.1 " 3325 UPDATE QnrS12 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_category "UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1447 UPDATE OKP-A-10 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-10 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051149.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1110 UPDATE LEN-19 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-19 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGGTCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM850909.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12347.2 UPDATED sequence with MRYVRLCVISLLATLPLAVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTVGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1113 UPDATE ANT(6)-Ib antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ANT(6)-Ib is an aminoglycoside nucleotidyltransferase gene encoded by transferable pathogenicity islands in C. fetus subsp. fetus and B. subtilis. UPDATED accession with FN594949.1 UPDATED category_aro_description with Nucelotidylylation of streptomycin at the hydroxyl group at position 6. " 1112 UPDATE OXA-58 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-58 is a beta-lactamase found in A. baumannii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5 UPDATE dfrF trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrF is a chromosome-encoded dihydrofolate reductase found in Streptococcus pyogenes. UPDATED accession with AF028812.1 " 1114 UPDATE ACT-17 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KF992026.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1441 UPDATE Klebsiella aerogenes Omp36 penam; reduced permeability to antibiotic; penem; carbapenem; cephalosporin; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; model_sequences; model_name; ARO_category "UPDATED accession with AF335467.1 UPDATED model_name with Klebsiella aerogenes Omp36 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1116 UPDATE arr-2 antibiotic inactivation; rifampin; rifapentine; rifabutin; rifampin ADP-ribosyltransferase (Arr); rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with arr-2 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. UPDATED accession with AF078527.1 " 1119 UPDATE EBR-1 beta-lactamase carbapenem; penam; cephalosporin; EBR beta-lactamase; antibiotic inactivation; ARO_name; model_sequences; model_name; ARO_category "UPDATED ARO_name with EBR-1 UPDATED accession with AF416700.1 UPDATED model_name with EBR-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1118 UPDATE OXA-2 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; ampicillin; amoxicillin; OXA beta-lactamase; meropenem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2660 UPDATE Enterobacter cloacae acrA penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; model_sequences; ARO_category "UPDATED accession with DQ679966.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1351 UPDATE QnrVC1 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrVC1 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. UPDATED partial with 0 UPDATED sequence with ATGGAAAAATCAAAGCAATTATATAATCAAGTGAACTTCTCACATCAGGACTTGCAAGAACATATCTTTAGCAATTGTACTTTTATACATTGTAATTTTAAGCGCTCAAACCTCCGAGATACACAGTTCATTAACTGTACTTTCATAGAGCAGGGGGCATTGGAAGGGTGCGATTTTTCTTATGCTGATCTTCGAGATGCTTCATTTAAAAACTGTCAGCTTTCAATGTCCCATTTTAAGGGGGCAAATTGCTTTGGTATTGAACTGAGAGATTGTGATCTTAAAGGAGCAAATTTTAGTCAAGTTAGTTTTGTAAATCAGGTTTCGAATAAAATGTACTTTTGTTCTGCATACATAACAGGTTGTAACTTATCCTATGCCAATTTTGAGCAGCAGCTTATTGAAAAATGTGACCTGTTCGAAAATAGATGGATTGGTGCAAATCTTCGAGGCGCTTCATTTAAAGAATCAGATTTAAGCCGTGGTGTTTTTTCGGAAGACTGCTGGGAACAGTTTAGAGTACAAGGCTGTGATTTAAGCCATTCAGAGCTTTATGGTTTAGATCCTCGAAAGATTGATCTTACGGGTGTAAAAATATGCTCGTGGCAACAGGAACAGTTACTGGAGCAATTAGGGGTAATCATTGTTCCTGACTAA UPDATED fmax with 2058 UPDATED accession with EU436855.2 UPDATED fmin with 1401 UPDATED strand with + UPDATED NCBI_taxonomy_name with Vibrio cholerae UPDATED NCBI_taxonomy_id with 666 UPDATED NCBI_taxonomy_cvterm_id with 36789 UPDATED accession with ACC54440.2 UPDATED sequence with MEKSKQLYNQVNFSHQDLQEHIFSNCTFIHCNFKRSNLRDTQFINCTFIEQGALEGCDFSYADLRDASFKNCQLSMSHFKGANCFGIELRDCDLKGANFSQVSFVNQVSNKMYFCSAYITGCNLSYANFEQQLIEKCDLFENRWIGANLRGASFKESDLSRGVFSEDCWEQFRVQGCDLSHSELYGLDPRKIDLTGVKICSWQQEQLLEQLGVIIVPD UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1449 UPDATE OXA-59 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-59 is a beta-lactamase found in Burkholderia pseudomallei. UPDATED accession with AJ632249.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1448 UPDATE SHV-26 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF227204.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4093 UPDATE KPC-29 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-29 [Klebsiella pneumoniae] Accession: WP_096807439.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4092 UPDATE KPC-27 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-27 [Klebsiella pneumoniae] Accession: WP_077064886.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4091 UPDATE KPC-18 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1350 UPDATE TEM-93 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ318093.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4097 UPDATE KPC-30 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-30 [Klebsiella pneumoniae] Accession: WP_085562399.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4096 UPDATE KPC-32 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-32 [Klebsiella pneumoniae] Accession: WP_073800284.1. UPDATED accession with MAPO01000050.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4095 UPDATE KPC-31 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-31 [Klebsiella] Accession: WP_073668892.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4094 UPDATE KPC-28 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-28 [Escherichia coli] Accession: WP_072081992.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2401 UPDATE Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrA; ARO_description "UPDATED ARO_description with Point mutation of Haemophilus parainfluenzae gyrA resulted in the lowered affinity between fluoroquinolones and GyrA. Thus, conferring resistance. Both Ser and Tyr are hydrophilic amino acids, however Tyr has an additional bulky hydrophobic group which could affect the interaction between the DNA gyrase with quinolones. " 4099 UPDATE KPC-34 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-34 [Klebsiella pneumoniae] Accession: WP_109545044.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4098 UPDATE KPC-33 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-33 [Klebsiella pneumoniae] Accession: WP_101140102.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 450 UPDATE OXA-51 penam; antibiotic inactivation; carbapenem; BAL30072; cephalosporin; monobactam; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-51 is a beta-lactamase found in A. baumannii. UPDATED partial with 0 UPDATED sequence with ATGAACATTAAAACACTCTTACTTATAACAAGCGCTATTTTTATTTCAGCCTGCTCACCTTATATAGTGACTGCTAATCCAAATCACAGCGCTTCAAAATCTGATGAAAAAGCAGAGAAAATTAAAAATTTATTTAACGAAGTACACACTACGGGTGTTTTAGTTATCCAACAAGGCCAAACTCAACAAAGCTATGGTAATGATCTTGCTCGTGCTTCGACCGAGTATGTACCTGCTTCGACCTTCAAAATGCTTAATGCTTTGATCGGCCTTGAGCACCATAAGGCAACCACCACAGAAGTATTTAAGTGGGACGGGCAAAAAAGGCTATTCCCAGAATGGGAAAAGGACATGACCCTAGGCGATGCTATGAAAGCTTCCGCTATTCCGGTTTATCAAGATTTAGCTCGTCGTATTGGACTTGAACTCATGTCTAAGGAAGTGAAGCGTGTTGGTTATGGCAATGCAGATATCGGTACCCAAGTCGATAATTTTTGGCTGGTGGGTCCTTTAAAAATTACTCCTCAGCAAGAGGCACAGTTTGCTTACAAGCTAGCTAATAAAACGCTTCCATTTAGCCCAAAAGTCCAAGATGAAGTGCAATCCATGTTATTCATAGAAGAAAAGAATGGAAATAAAATATACGCAAAAAGTGGTTGGGGATGGGATGTAGACCCACAAGTAGGCTGGTTAACTGGATGGGTTGTTCAGCCTCAAGGAAATATTGTAGCGTTCTCCCTTAACTTAGAAATGAAAAAAGGAATACCTAGCTCTGTTCGAAAAGAGATTACTTATAAAAGTTTAGAACAATTAGGTATTTTATAG UPDATED fmax with 825 UPDATED accession with AJ309734.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with CAC83905.2 UPDATED sequence with MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4826 UPDATE OXA-307 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4857 UPDATE OXA-522 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 463 UPDATE CTX-M-30 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-30 is a beta-lactamase found in Citrobacter freundii. UPDATED accession with AY292654.1 " 489 UPDATE Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin antibiotic target alteration; streptomycin; aminoglycoside antibiotic; antibiotic resistant gidB; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant. UPDATED partial with 0 UPDATED sequence with ATGTCTCCGATCGAGCCCGCGGCGTCTGCGATCTTCGGACCGCGGCTTGGCCTTGCTCGGCGGTACGCCGAAGCGTTGGCGGGACCCGGTGTGGAGCGGGGGCTGGTGGGACCCCGCGAAGTCGGTAGGCTATGGGACCGGCATCTACTGAACTGCGCCGTGATCGGTGAGCTCCTCGAACGCGGTGACCGGGTCGTGGATATCGGTAGCGGAGCCGGGTTGCCGGGCGTGCCATTGGCGATAGCGCGGCCGGACCTCCAGGTAGTTCTCCTAGAACCGCTACTGCGCCGCACCGAGTTTCTTCGAGAGATGGTGACAGATCTGGGCGTGGCCGTTGAGATCGTGCGGGGGCGCGCCGAGGAGTCCTGGGTGCAGGACCAATTGGGCGGCAGCGACGCTGCGGTGTCACGGGCGGTGGCCGCGTTGGACAAGTTGACGAAATGGAGCATGCCGTTGATACGGCCGAACGGGCGAATGCTCGCCATCAAAGGCGAGCGGGCTCACGACGAAGTACGGGAGCACCGGCGTGTGATGATCGCATCGGGCGCGGTTGATGTCAGGGTGGTGACATGTGGCGCGAACTATTTGCGTCCGCCCGCGACCGTGGTGTTCGCACGACGTGGAAAGCAGATCGCCCGAGGGTCGGCACGGATGGCGAGTGGAGGGACGGCGTGA UPDATED fmax with 4408202 UPDATED accession with AL123456.3 UPDATED fmin with 4407527 UPDATED strand with - UPDATED NCBI_taxonomy_name with Mycobacterium tuberculosis H37Rv UPDATED NCBI_taxonomy_id with 83332 UPDATED NCBI_taxonomy_cvterm_id with 39507 UPDATED accession with CCP46748.1 UPDATED sequence with MSPIEPAASAIFGPRLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLERGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGVAVEIVRGRAEESWVQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVREHRRVMIASGAVDVRVVTCGANYLRPPATVVFARRGKQIARGSARMASGGTA UPDATED category_aro_description with GidB is a m7G methyltransferase specific for 16S rRNA. Mutations within the gidB gene causes changes in the structure or 16s rRNA, leading to resistance to aminoglycosides. " 488 UPDATE SHV-156 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121123.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 487 UPDATE macB efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; macrolide antibiotic; erythromycin; model_sequences "UPDATED accession with AY768532.1 " 486 UPDATE cmlB antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmlB is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella aerogenes. UPDATED partial with 1 UPDATED sequence with GAATTGCTTGAGAATTGTTACGATTCAAATTCAGCCATGAGATAGTCAGCAAATGAGCACTTCCAAGAAAGCAGACAAGTAAGCCGCAGCAACCTTCATTTTTCGGTTGTTGCGGCGTTCTCATGAACCCTTTTGCTCTACGGGAGCGCCGCCAAATCCTTCGTTCAAGGAGATGGTTTCGTGCGCTCAAAGAACTGTAATTGGCGGTATTCCCTTGCCGTCACTGTGTTGTTGTTATCACCTTTCGATTTACTGGCATCACTCGGCATGGACATGTACTTGCCAGCGGTGCCTTTCATGCCACATGCTCTTGGTACGACAGCGGGCACAATTCAGCTTACGCTGACAACGTATTTGGTCATGATAGGGGCCGGTCAGCTTTTGTTTGGGCCACTGTCGGACCGGCTGGGACGTCGTCCCGTGCTACTGGCGGGCGGTGCCGCCTACGTTGCGGCCTCAATCGGCCTCGTCGTCACGTCATCGGCTGGAGTATTTCTGGGTTTTCGGATTCTCCAAGCTTGTGGTGCCTCGGCATGCCTTGTTGCCACATTTGCAACAGTGCGTGATATCTACGCAGGTCGCAAGGAAAGTAACGTCATCTACGGCTTGCTTGGCTCTATGCTTGCTATGGTTCCGGCGATAGGCCCATTGCTGGGAGCGGTCATAGACACCTGGTTCGGGTGGCGGGCGATCTTTGCGTTCTTGGGATTGGGAATGATCGCTGCATTGACAGCAGCGTGGCGGCTCTGGCCTGAGACCCGGGTGCAGCGACCAGCAGCTTTGCAATGGTCACAACTTCTGCTTCCCATCAAGCACCTTAACTTCTGGTTGTACACAGTGTGTTATGCCGCAGGAATGGGCAGCTTCTTCGTCTTCTTCTCCATAGCGCCCGGATTGATGATGGGTAGGCAAGGCATGTCCCAGTTTGGCTTCAGTCTGTTGTTCGCAACAGTGGCAATTGCGATGATGCTTGCGGCCCGCTTCATGGGGCGCGTAATCGCCAAGTGGGGCAGCCTGAGTGCCTTGCGAATGGGGATGGGCTGCCTGATAGCAGGCGCAGTCTTGCTTGTCATCACCGAGCTATGGATTCCGCAGTCCGTGTTGGGCTTTATTGCCCCAATGTGGCTAGTGGGCGTCGGCGTCGCGACAGCGGTATCCGTTGCACCCAATGGTGCGCTTCGAGGGTTCGACCATATTGCAGGAGCCGTTACGGCAGTCTACTTCTGCTTGGGGGGGCTGCTGCTGGGGAGTGTTGGAACGCTCATCATTTCGCTGTTGCCGCGCGACACGGCCTGGCCAGTTATCGCGTATTGTTTGGTTCTTGCAACAATCGTGCTTGGACTGTCGTGTGTTTCCCGAGCGAGAGACCTTCGCGGTCACGGGGAGTATGATGCGGTTGCACGCACATAG UPDATED fmax with 3871 UPDATED accession with AF034958.3 UPDATED fmin with 2461 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella aerogenes UPDATED NCBI_taxonomy_id with 548 UPDATED NCBI_taxonomy_cvterm_id with 36770 UPDATED accession with AAD22144.1 UPDATED sequence with MRSKNCNWRYSLAVTVLLLSPFDLLASLGMDMYLPAVPFMPHALGTTAGTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLAGGAAYVAASIGLVVTSSAGVFLGFRILQACGASACLVATFATVRDIYAGRKESNVIYGLLGSMLAMVPAIGPLLGAVIDTWFGWRAIFAFLGLGMIAALTAAWRLWPETRVQRPAALQWSQLLLPIKHLNFWLYTVCYAAGMGSFFVFFSIAPGLMMGRQGMSQFGFSLLFATVAIAMMLAARFMGRVIAKWGSLSALRMGMGCLIAGAVLLVITELWIPQSVLGFIAPMWLVGVGVATAVSVAPNGALRGFDHIAGAVTAVYFCLGGLLLGSVGTLIISLLPRDTAWPVIAYCLVLATIVLGLSCVSRARDLRGHGEYDAVART " 485 UPDATE TEM-191 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 484 UPDATE QnrB49 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB49 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JQ582718.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 483 UPDATE GES-7 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-7 is a beta-lactamase found in Enterobacter cloacae. UPDATED partial with 0 UPDATED sequence with ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCATCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCAAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGGGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG UPDATED fmax with 5341 UPDATED accession with AY260546.3 UPDATED fmin with 4477 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAP22974.1 UPDATED sequence with MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 482 UPDATE LEN-1 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with X04515.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 481 UPDATE VIM-30 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-30 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with JN129451.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 480 UPDATE GES-9 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-9 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AY920928.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 2009 UPDATE aadA6 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA6 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. UPDATED accession with AM087411.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 790 UPDATE CMY-32 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-32 is a beta-lactamase found in Escherichia coli. UPDATED accession with EU496815.1 " 4580 UPDATE DHA-27 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4725 UPDATE KPC-62 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4379 UPDATE BlaB-18 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4724 UPDATE KPC-61 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1061 UPDATE OXY-2-10 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; model_sequences; ARO_category "UPDATED accession with FJ785626.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4727 UPDATE KPC-64 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3922 UPDATE SHV-205 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-Nov-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3923 UPDATE SHV-222 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3920 UPDATE CMY-96 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_048893.1 " 723 UPDATE SHV-72 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATTTTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGTAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAGGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 891 UPDATED accession with AM176547.2 UPDATED fmin with 30 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47127.2 UPDATED sequence with MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3926 UPDATE SHV-201 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3927 UPDATE SHV-212 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3924 UPDATE SHV-198 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 10-AGU-2017. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3925 UPDATE SHV-195 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4721 UPDATE KPC-58 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3928 UPDATE SHV-204 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 26-JUN-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3929 UPDATE SHV-197 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene from Escherichia coli. Directly submitted to NCBI without publication on 05-JAN-2017. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 656 UPDATE OXA-219 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-219 is a beta-lactamase found in A. baumannii. UPDATED accession with JN215211.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3993 UPDATE TEM-230 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5656 UPDATE SHV-171 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4723 UPDATE KPC-60 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4789 UPDATE OKP-B-36 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4373 UPDATE BlaB-12 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4787 UPDATE OKP-B-24 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4786 UPDATE OKP-B-23 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4785 UPDATE OKP-B-22 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4784 UPDATE OKP-B-21 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4783 UPDATE OKP-B-16 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4782 UPDATE OKP-A-17 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4780 UPDATE NDM-31 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1051 UPDATE LEN-12 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with LEN-12 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4371 UPDATE BlaB-10 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4149 UPDATE ACT-58 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4148 UPDATE ACT-57 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4145 UPDATE ACT-54 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5652 UPDATE SHV-115 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4147 UPDATE ACT-56 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4146 UPDATE ACT-55 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4141 UPDATE ACT-50 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4140 UPDATE ACT-49 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4143 UPDATE ACT-52 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4142 UPDATE ACT-51 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3856 UPDATE OXA-846 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3857 UPDATE NDM-29 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5651 UPDATE SHN-1 carbapenem; antibiotic inactivation; SHN beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4822 UPDATE OXA-114w carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2661 UPDATE Escherichia coli acrA penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1062 UPDATE SHV-71 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAATACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGTAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM176546.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47126.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKYLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4814 UPDATE OXA-114n carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 455 UPDATE vanC glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; model_sequences; ARO_category "UPDATED accession with AF162694.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 1182 UPDATE CTX-M-105 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-105 is a beta-lactamase found in Escherichia coli. UPDATED accession with HQ833651.1 " 924 UPDATE AAC(6')-33 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with JN596280.1 " 16 UPDATE KPC-10 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with KPC-10 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with GQ140348.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5089 UPDATE OXA-781 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3665 UPDATE NDM-24 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2896 UPDATE Staphylococcus intermedius chloramphenicol acetyltransferase antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with A chloramphenicol resistance determinant described in Staphylococcus intermedius. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 199 UPDATE SRT-1 antibiotic inactivation; cephalosporin; SRT beta-lactamase; model_sequences "UPDATED accession with AB008454.1 " 198 UPDATE TEM-138 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY853593.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 195 UPDATE CTX-M-58 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-58 is a beta-lactamase found in Escherichia coli. UPDATED accession with EF210159.1 " 194 UPDATE SHV-61 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCGGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AJ866284.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAI30650.2 UPDATED sequence with MRYIRRCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 197 UPDATE CTX-M-56 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-56 is a beta-lactamase found in Escherichia coli. UPDATED accession with EF374097.1 " 196 UPDATE Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol antibiotic target alteration; polyamine antibiotic; ethambutol; ethambutol resistant embB; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol. UPDATED accession with AL123456.1 UPDATED model_name with Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol " 191 UPDATE OXA-199 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN704570.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 190 UPDATE OXA-195 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ425493.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 193 UPDATE TEM-121 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY271267.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 192 UPDATE CTX-M-38 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-38 is a beta-lactamase found in Escherichia coli. UPDATED accession with AY822595.1 " 19 UPDATE IMP-2 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-2 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with AJ243491.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 457 UPDATE OXA-93 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-93 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ519087.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1454 UPDATE CMY-112 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM087837.1 " 1455 UPDATE IND-9 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-9 is a beta-lactamase found in Escherichia coli. UPDATED accession with GU186045.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 1456 UPDATE IMP-15 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-15 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AY553333.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 18 UPDATE OXA-212 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN861780.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2381 UPDATE Staphylococcus aureus UhpT with mutation conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant UhpT; model_sequences "UPDATED accession with CAG39240.1 " 2380 UPDATE Staphylococcus aureus GlpT with mutation conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant GlpT; model_sequences "UPDATED accession with CAG39357.1 " 2383 UPDATE ANT(4')-Ib antibiotic inactivation; aminoglycoside antibiotic; ribostamycin; paromomycin; kanamycin A; gentamicin B; lividomycin B; ANT(4'); lividomycin A; isepamicin; G418; neomycin; tobramycin; ARO_description; ARO_category "UPDATED ARO_description with Kanamycin nucleotidyltransferase sequence from Staphylococcus aureus plasmid. Confers resistance to kanamycin, neomycin and other aminoglycosides. UPDATED category_aro_description with Nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 4'. " 1457 UPDATE CTX-M-13 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-13 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED partial with 0 UPDATED sequence with ATGGTGACAAAGAGAATGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTGCTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCAAAGATAATACGCAGGTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCAAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATGACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGAGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGTGGGTGATAAGACCGGCAGCGGCGACTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTGGTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTGGCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA UPDATED fmax with 876 UPDATED accession with AF252623.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAF72531.1 UPDATED sequence with MVTKRMQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTKDNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFAREIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL " 2386 UPDATE cipA dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 1450 UPDATE Escherichia coli parC conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance. UPDATED model_name with Escherichia coli parC conferring resistance to fluoroquinolones " 1451 UPDATE MIR-17 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with LN515535.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 3580 UPDATE DES-1 penam; antibiotic inactivation; DES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3581 UPDATE DHA-9 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGACAAAATCTGTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCAGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCATTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA UPDATED fmax with 2091 UPDATED accession with KJ207201.1 UPDATED fmin with 951 UPDATED strand with + UPDATED NCBI_taxonomy_name with Morganella morganii UPDATED NCBI_taxonomy_id with 582 UPDATED NCBI_taxonomy_cvterm_id with 36917 UPDATED accession with AHL39320.1 UPDATED sequence with MTKSVSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSHYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE " 3582 UPDATE ERP-1 penam; antibiotic inactivation; ERP beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2768 UPDATE MdtEF-TolC penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; cloxacillin; fluoroquinolone antibiotic; erythromycin; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5007 UPDATE OXA-695 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3585 UPDATE FONA-1 penam; antibiotic inactivation; FONA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3586 UPDATE FONA-2 penam; antibiotic inactivation; FONA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3587 UPDATE FONA-3 penam; antibiotic inactivation; FONA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2763 UPDATE MdtABC-TolC efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; aminocoumarin antibiotic; resistance-nodulation-cell division (RND) antibiotic efflux pump; novobiocin; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 3589 UPDATE FONA-5 penam; antibiotic inactivation; FONA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2761 UPDATE MexPQ-OpmE kitasamycin; imipenem; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; rokitamycin; antibiotic efflux; trimethoprim; macrolide antibiotic; disinfecting agents and antiseptics; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; acriflavine; tetracycline antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; erythromycin; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 2760 UPDATE MexGHI-OpmD antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and antiseptics; tetracycline; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 2766 UPDATE EmrKY-TolC tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 2765 UPDATE EmrAB-TolC efflux pump complex or subunit conferring antibiotic resistance; nalidixic acid; major facilitator superfamily (MFS) antibiotic efflux pump; fluoroquinolone antibiotic; antibiotic efflux; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 999 UPDATE LEN-2 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-2 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY037780.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2007 UPDATE OXA-335 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203109.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3552 UPDATE ARL-4 penam; antibiotic inactivation; ARL Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 902 UPDATE OXA-92 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-92 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ335566.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 903 UPDATE APH(2'')-Ig antibiotic inactivation; kanamycin A; gentamicin B; aminoglycoside antibiotic; sisomicin; arbekacin; APH(2''); netilmicin; gentamicin C; amikacin; isepamicin; tobramycin; ARO_description; ARO_category "UPDATED ARO_description with APH('')-Ig is a plasmid-encoded aminoglycoside phosphotransferase in Campylobacter coli. UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''. " 1849 UPDATE Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides antibiotic target alteration; capreomycin; streptomycin; aminoglycoside antibiotic; Antibiotic resistant tlyA; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Specific mutations that arise in Mycobacterium tuberculosis tlyA resulting in aminoglycosides resistance. UPDATED accession with AE000516.1 UPDATED category_aro_description with tlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA. " 1848 UPDATE CTX-M-75 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-75 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with GQ149244.1 " 906 UPDATE CARB-21 penam; antibiotic inactivation; CARB beta-lactamase; model_sequences; ARO_category "UPDATED accession with CP006005.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 907 UPDATE fexA antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; florfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with fexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus. UPDATED accession with AJ549214.1 UPDATED NCBI_taxonomy_name with Mammaliicoccus lentus " 4621 UPDATE GES-38 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4422 UPDATE CARB-36 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1842 UPDATE IMI-3 carbapenem; antibiotic inactivation; IMI beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with IMI-3 is a beta-lactamase found in Enterobacteriaceae. UPDATED accession with GU015024.1 " 1841 UPDATE OXA-76 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-76 is a beta-lactamase found in A. baumannii. UPDATED accession with AY949203.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1840 UPDATE CMY-59 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with AB587082.1 " 1847 UPDATE emrB efflux pump complex or subunit conferring antibiotic resistance; nalidixic acid; major facilitator superfamily (MFS) antibiotic efflux pump; fluoroquinolone antibiotic; antibiotic efflux; model_sequences "UPDATED accession with U00096.1 " 4427 UPDATE CARB-43 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1845 UPDATE OXA-312 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-312 is a beta-lactamase found in A. baumannii. UPDATED accession with KF057029.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1844 UPDATE OXA-128 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-128 is a beta-lactamase found in A. baumannii. UPDATED accession with EU375515.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4958 UPDATE OXA-632 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4959 UPDATE OXA-633 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1188 UPDATE ErmV antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with ErmV is a plasmid-mediated methyltransferase found in Streptomyces viridochromogenes. UPDATED accession with U59450.1 " 4952 UPDATE OXA-626 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4953 UPDATE OXA-627 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4950 UPDATE OXA-624 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4951 UPDATE OXA-625 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4956 UPDATE OXA-630 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4957 UPDATE OXA-631 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4954 UPDATE OXA-628 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 925 UPDATE AAC(3)-IIb antibiotic inactivation; AAC(3); gentamicin B; gentamicin C; amikacin; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-IIb is an aminoglycoside acetyltransferase in E. coli, A. faecalis and S. marcescens. UPDATED accession with M97172.1 " 2614 UPDATE mphE antibiotic inactivation; macrolide phosphotransferase (MPH); macrolide antibiotic; ARO_description "UPDATED ARO_description with mphE is a macrolide phosphotransferase and resistance gene identified on a plasmid, pRSB105. " 4626 UPDATE GES-43 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 2147 UPDATE Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa antibiotic target alteration; elfamycin antibiotic; enacyloxin IIa; elfamycin resistant EF-Tu; ARO_description "UPDATED ARO_description with Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa. " 4627 UPDATE GES-44 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4082 UPDATE DfrB9 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED accession with NG_052167.1 " 3255 UPDATE dfrA6 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with A dihydrofolate reductase and antibiotic resistance gene identified from an integron in Vibrio cholerae. " 4083 UPDATE DfrA39 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED accession with NG_070722.1 " 3298 UPDATE Klebsiella pneumoniae KpnG penem; piperacillin; antibiotic efflux; imipenem; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; spectinomycin; ciprofloxacin; gentamicin C; streptomycin; aminoglycoside antibiotic; polymyxin B1; peptide antibiotic; ticarcillin; ertapenem; penam; efflux pump complex or subunit conferring antibiotic resistance; polymyxin B2; polymyxin B3; polymyxin B4; fluoroquinolone antibiotic; erythromycin; azithromycin; tobramycin; ARO_description; ARO_category "UPDATED ARO_description with KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3299 UPDATE Klebsiella pneumoniae KpnH penem; piperacillin; antibiotic efflux; imipenem; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; spectinomycin; ciprofloxacin; gentamicin C; streptomycin; aminoglycoside antibiotic; polymyxin B1; peptide antibiotic; ticarcillin; ertapenem; penam; efflux pump complex or subunit conferring antibiotic resistance; polymyxin B2; polymyxin B3; polymyxin B4; fluoroquinolone antibiotic; erythromycin; azithromycin; tobramycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5139 UPDATE OXA-840 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5138 UPDATE OXA-839 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5136 UPDATE OXA-834 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5135 UPDATE OXA-833 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5132 UPDATE OXA-830 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5130 UPDATE OXA-828 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 854 UPDATE CMY-58 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with HQ185697.1 " 855 UPDATE TEM-142 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ388882.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3450 UPDATE OXA-285 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3451 UPDATE OXA-287 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3456 UPDATE OXA-293 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3457 UPDATE OXA-294 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3454 UPDATE OXA-291 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 853 UPDATE OXA-160 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-160 is a beta-lactamase found in A. baumannii. UPDATED partial with 0 UPDATED sequence with ATGAAAAAATTTATACTTCCTATATTCAGCATTTCTATTCTAGTTTCTCTCAGTGCATGTTCATCTATTAAAACTAAATCTGAAGATAATTTTCATATTTCTTCTCAGCAACATGAAAAAGCTATTAAAAGCTATTTTGATGAAGCTCAAACACAGGGTGTAATTATTATTAAAGAGGGTAAAAATCTTAGCACCTATGGTAATGCTCTTGCACGAGCAAATAAAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCTTTAATCGGGCTAGAAAATCATAAAGCAACAACAAATGAGATTTTCAAATGGGATGGTAAAAAAAGAACTTATCCTATGTGGGAGAAAGATATGACTTTAGGTGAGGCAATGGCATTGTCAGCAGTTCCAGTATATCAAGAGCTTGCAAGACGGACTGGCCTAGAGCTAATGCAGAAAGAAGTAAAGCGGGTTAATTTTGGAAATACAAATATTGGAACACAGGTCGATAATTTTTGGTTAGTTGGCCCCCTTAAAATTACACCAGTACAAGAAGTTAATTTTGCCGATGACCTTGCACATAACCGATTACCTTTTAAATTAGAAACTCAAGAAGAAGTTAAAAAAATGCTTCTAATTAAAGAAGTAAATGGTAGTAAGATTTATGCAAAAAGTGGATGGGGAATGGGTGTTACTTCACAGGTAGGTTGGTTGACTGGTTGGGTGGAGCAAGCTAATGGAAAAAAAATCCCCTTTTCGCTCAACTTAGAAATGAAAGAAGGAATGTCTGGTTCTATTCGTAATGAAATTACTTATAAGTCGCTAGAAAATCTTGGAATCATTTAA UPDATED fmax with 2023 UPDATED accession with GU199038.2 UPDATED fmin with 1195 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with ADB28891.1 UPDATED sequence with MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTSQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3458 UPDATE OXA-295 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3459 UPDATE OXA-297 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 858 UPDATE IND-14 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-14 is a beta-lactamase found in Escherichia coli. UPDATED accession with HM367709.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 88 UPDATE CMY-55 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-55 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with HM544040.1 " 721 UPDATE OXA-28 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-28 is a beta-lactamase found in P. aeruginosa. UPDATED accession with AF231133.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4088 UPDATE KPC-23 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-23 [Klebsiella pneumoniae] Accession: WP_111672911.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3862 UPDATE OXA-906 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4813 UPDATE OXA-114m carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1187 UPDATE OXA-248 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-248 is a beta-lactamase found in A. baumannii. UPDATED accession with HE963769.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3864 UPDATE OXA-850 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Pseudomonas aeruginosa strain OXA-50 family oxacillin-hydrolyzing class D beta-lactamase. UPDATED accession with MN370858.1 UPDATED accession with QEJ80887.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5229 UPDATE OXA-945 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5228 UPDATE OXA-943 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5223 UPDATE OXA-938 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5222 UPDATE OXA-937 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5221 UPDATE OXA-935 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5220 UPDATE OXA-932 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5227 UPDATE OXA-942 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5226 UPDATE OXA-941 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5225 UPDATE OXA-940 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5224 UPDATE OXA-939 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1554 UPDATE norA antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and antiseptics; model_sequences; ARO_category "UPDATED accession with AY566250.1 UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 740 UPDATE QnrB21 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB21 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED accession with FJ611948.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 741 UPDATE CfxA antibiotic inactivation; flomoxef; cefmetazole; cephamycin; cefotetan; CfxA beta-lactamase; cefoxitin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CfxA beta-lactamase is a class A beta-lactamase found in Bacteroides vulgatus. UPDATED accession with U38243.1 UPDATED category_aro_description with CfxA beta-lactamases are class A beta-lactamases. " 742 UPDATE AAC(3)-Id antibiotic inactivation; AAC(3); sisomicin; gentamicin B; astromicin; gentamicin C; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-Id is an aminoglycoside acetyltransferase encoded by genomic islands and integrons in S. enterica, P. mirabilis and Vibrio fluvialis. UPDATED accession with AY458224.1 " 743 UPDATE arr-3 antibiotic inactivation; rifampin; rifapentine; rifabutin; rifampin ADP-ribosyltransferase (Arr); rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with arr-3 is a plasmid-encoded ribosyltransferase found in Vibrio fluvialis. UPDATED accession with EU675686.1 " 744 UPDATE vanSL glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSL, is a vanS variant found in the vanL gene cluster. UPDATED accession with EU250284.1 UPDATED model_name with vanS gene in vanL cluster UPDATED ARO_name with vanS gene in vanL cluster " 745 UPDATE CMY-40 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-40 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with EU515251.1 " 746 UPDATE AAC(2')-Ib antibiotic inactivation; AAC(2'); arbekacin; gentamicin B; gentamicin C; amikacin; aminoglycoside antibiotic; tobramycin; ARO_description; model_sequences "UPDATED ARO_description with AAC(2')-Ib is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium fortuitum and A. baumannii. UPDATED accession with U41471.1 " 747 UPDATE QnrA4 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrA4 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. UPDATED accession with DQ058662.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 748 UPDATE cmeB antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; cefotaxime; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; fluoroquinolone antibiotic; fusidic acid; erythromycin; model_sequences "UPDATED accession with CP000768.1 " 4811 UPDATE OXA-114k carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1185 UPDATE OXA-176 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-176 is a beta-lactamase found in A. baumannii. UPDATED accession with HM113562.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1799 UPDATE TEM-147 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ279850.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2913 UPDATE OXA-286 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Acinetobacter proteolyticus UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 926 UPDATE KPC-15 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC433553.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1050 UPDATE AAC(6')-Ii AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; plazomicin; model_sequences "UPDATED accession with L12710.1 " 1058 UPDATE VIM-27 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-27 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with HQ858608.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1059 UPDATE APH(9)-Ib antibiotic inactivation; aminoglycoside antibiotic; APH(9); spectinomycin; ARO_description; ARO_category "UPDATED ARO_description with APH(9)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. flavopersicus. UPDATED category_aro_description with Phosphorylation of spectinomycin on the hydroxyl group at position 9. " 1696 UPDATE Salmonella serovars gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutation in Salmonella serovars resulting in fluoroquinolone resistance. UPDATED model_name with Salmonella serovars gyrB conferring resistance to fluoroquinolones " 1697 UPDATE TEM-135 penam; antibiotic inactivation; penem; cephalosporin; penicillin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1694 UPDATE OXA-353 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297582.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1695 UPDATE DHA-5 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with JF273491.1 " 1693 UPDATE TEM-143 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ075245.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1690 UPDATE OXA-317 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-317 is a beta-lactamase found in A. baumannii. UPDATED accession with KF057034.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1691 UPDATE CMY-31 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-31 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with EF622224.1 " 715 UPDATE PDC-3 penam; carbapenem; monobactam; piperacillin-tazobactam; cephalosporin; cefazolin; ampicillin; ceftazidime; cefalotin; cephamycin; antibiotic inactivation; cefixime; amoxicillin; PDC beta-lactamase; clavulanic acid; piperacillin; tazobactam; ceftriaxone; cefoxitin; amoxicillin-clavulanic acid; model_sequences; ARO_category "UPDATED accession with FJ666066.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1698 UPDATE OCH-6 penam; antibiotic inactivation; penem; cephalosporin; cephamycin; monobactam; OCH beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OCH-6 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. UPDATED accession with AJ295344.1 UPDATED NCBI_taxonomy_name with Brucella anthropi UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. " 1699 UPDATE vanXO glycopeptide antibiotic; glycopeptide resistance gene cluster; vanX; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXO, is a vanX variant found in the vanO gene cluster. UPDATED accession with KF478993.1 UPDATED model_name with vanX gene in vanO cluster UPDATED ARO_name with vanX gene in vanO cluster " 1279 UPDATE TEM-104 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF516719.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 619 UPDATE SHV-30 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY661885.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4817 UPDATE OXA-114r carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 612 UPDATE PDC-7 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED accession with FJ666070.1 " 1272 UPDATE CTX-M-67 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-67 is a beta-lactamase found in Escherichia coli. UPDATED accession with EF581888.1 " 611 UPDATE OXA-328 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203102.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 616 UPDATE NDM-8 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with NDM-8 is a beta-lactamase found in Escherichia coli. UPDATED accession with AB744718.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1275 UPDATE ErmT antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with M64090.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 614 UPDATE SFB-1 penam; antibiotic inactivation; cephalosporin; SHW beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY590119.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1277 UPDATE GES-16 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM173356.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 711 UPDATE SHV-62 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAATACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCAGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AJ866285.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAI30651.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKYLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 615 UPDATE OXA-211 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN861779.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4911 UPDATE OXA-585 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4429 UPDATE CARB-45 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 710 UPDATE dfrB6 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrB6 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. UPDATED accession with GU060319.1 " 1633 UPDATE catQ antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with catQ is a chromosome-encoded variant of the cat gene found in Clostridium perfringens. UPDATED accession with M55620.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 331 UPDATE TEM-166 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ197316.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3333 UPDATE ADC-73 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with A class C ADC beta-lactamase and cephalosporinase found in Acinetobacter baumannii. " 4816 UPDATE OXA-114q carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1180 UPDATE mdsC penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; penem; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; monobactam; phenicol antibiotic; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3332 UPDATE ADC-67 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with A class C beta-lactamase and cephalosporinase from Acinetobacter baumannii. " 4926 UPDATE OXA-600 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3331 UPDATE ADC-62 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with A class ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. " 1472 UPDATE DHA-18 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087841.1 " 1473 UPDATE CTX-M-44 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-44 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with D37830.1 " 1470 UPDATE QnrB26 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB26 is a plasmid-mediated quinolone resistance protein found in Proteus vulgaris. UPDATED accession with HQ386846.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3330 UPDATE Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrA; model_name "UPDATED model_name with Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones " 1476 UPDATE TEM-199 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX050178.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1474 UPDATE MexR sulfonamide antibiotic; penem; panipenem; antibiotic target alteration; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1475 UPDATE SHV-99 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM941845.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3337 UPDATE Corynebacterium striatum tetA penam; antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; oxytetracycline; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; tetracycline antibiotic; tetracycline; ARO_description; ARO_category "UPDATED ARO_description with The tetAB genes of the Corynebacterium striatum R-plasmid encode an ABC transporter and confer tetracycline, oxytetracycline, and oxalic resistance. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1478 UPDATE CARB-10 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-10 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with EU850412.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1479 UPDATE IMP-40 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with AB753457.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1495 UPDATE ACT-4 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCACCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGCCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACCCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTTACCGGCGTACTGGGTGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACGGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTACCGGATGAGGTCGCGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGTACCACGCGTCTTTACGCCAATACCAGCATCGGCCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAACAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTACACGTTTCGCCAGGCATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGCAAGGCATTGCCCTGGCGCAGTCTCGCTACTGGCGCGTAGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCACTGGCACCGCTGCCCGCAAGAGAAGTGAATCCTCCGGCGCCTCCGGTCAACGCGTCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCCAACCCAGCACGCGTTGAGGCGGCTTACCGTATTTTGAGCGCGCTGTAG UPDATED fmax with 2618 UPDATED accession with EU427302.2 UPDATED fmin with 1475 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterobacter asburiae UPDATED NCBI_taxonomy_id with 61645 UPDATED NCBI_taxonomy_cvterm_id with 36926 UPDATED accession with ABZ81086.1 UPDATED sequence with MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVADNASLLRFYQNWQPQWKPGTTRLYANTSIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1304 UPDATE CTX-M-85 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-85 is a beta-lactamase found in Salmonella enterica. UPDATED accession with FJ214368.1 " 1305 UPDATE OprM sulfonamide antibiotic; tetracycline; erythromycin; penem; panipenem; thiamphenicol; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; ofloxacin; norfloxacin; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; gentamicin C; amikacin; ceftriaxone; disinfecting agents and antiseptics; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; amoxicillin; penam; aminoglycoside antibiotic; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; nalidixic acid; azithromycin; tobramycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 1306 UPDATE IND-5 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-5 is a beta-lactamase found in Chryseobacterium indologenes. UPDATED accession with AY504627.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 1307 UPDATE OXY-1-6 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-1-6 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with Y17715.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1301 UPDATE Staphylococcus aureus cls conferring resistance to daptomycin peptide antibiotic; antibiotic target alteration; daptomycin resistant cls; daptomycin; ARO_description "UPDATED ARO_description with Cardiolipin synthetase (cls) is an inner membrane protein that is involved in membrane synthesis. Specific mutations in S. aureus can confer resistance to daptomycin. " 1303 UPDATE BEL-2 penam; monobactam; cephalosporin; antibiotic inactivation; BEL beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with BEL-2 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with FJ666063.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3334 UPDATE AAC(6')-Il AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Il is an aminoglycoside acetyltransferase encoded by plasmids and integrons in Enterobacter cloaecae and Klebsiella aerogenes. UPDATED partial with 0 UPDATED sequence with ATGGATAGTTCGCCGCTCGTCAGGCCTGTTGAAACTACCGATTCGGCCAGTTGGCTAAGCATGCGCTGTGAGCTGTGGCCAGATGGCACATGTCAAGAGCACCAGTCAGAGATCGCAGAATTTCTGTCCGGAAAAGTCGCCCGGCCTGCTGCTGTCCTCATTGCTGTAGCACCCGACGGAGAAGCACTAGGGTTTGCCGAGCTTTCGATCCGCCCGTATGCGGAGGAGTGCTACTCCGGCAACGTTGCGTTCTTGGAGGGTTGGTACGTTGTGCCAAGTGCGCGGCGTCAGGGCGTAGGTGTAGCTCTGGTAAAAGCCGCCGAGCATTGGGCTCGTGGTCGCGGATGCACCGAATTCGCCTCCGACACTCAACTTACCAACAGCGCAAGCACCTCGGCGCACCTGGCGGCTGGATTCACGGAGGTTGCTCAAGTACGCTGCTTCCGGAAACCGTTGTGA UPDATED fmax with 767 UPDATED accession with U13880.2 UPDATED fmin with 308 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella aerogenes UPDATED NCBI_taxonomy_id with 548 UPDATED NCBI_taxonomy_cvterm_id with 36770 UPDATED accession with AAA90937.1 UPDATED sequence with MDSSPLVRPVETTDSASWLSMRCELWPDGTCQEHQSEIAEFLSGKVARPAAVLIAVAPDGEALGFAELSIRPYAEECYSGNVAFLEGWYVVPSARRQGVGVALVKAAEHWARGRGCTEFASDTQLTNSASTSAHLAAGFTEVAQVRCFRKPL " 1308 UPDATE vanTE glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanT; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanTE, is a vanT variant found in the vanE gene cluster. UPDATED accession with FJ872411.1 UPDATED model_name with vanT gene in vanE cluster UPDATED ARO_name with vanT gene in vanE cluster " 1309 UPDATE ACT-20 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KF526117.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 498 UPDATE QnrB17 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB17 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with AM919398.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 499 UPDATE vanSB glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSB, is a vanS variant found in the vanB gene cluster. UPDATED accession with U35369.1 UPDATED model_name with vanS gene in vanB cluster UPDATED ARO_name with vanS gene in vanB cluster " 494 UPDATE KPC-14 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX524191.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 495 UPDATE CMY-28 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with EF561644.1 " 497 UPDATE OXA-79 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-79 is a beta-lactamase found in A. baumannii. UPDATED accession with EU019534.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 20 UPDATE CMY-1 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-1 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with X92508.1 " 21 UPDATE OXA-329 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203103.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 23 UPDATE OXA-371 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB871653.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 927 UPDATE OXA-381 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ135344.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 28 UPDATE OXA-45 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-45 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AJ519683.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 29 UPDATE Escherichia coli folP with mutation conferring resistance to sulfonamides sulfadiazine; sulfadoxine; sulfacetamide; sulfadimidine; mafenide; sulfonamide resistant dihydropteroate synthase folP; sulfisoxazole; antibiotic target alteration; sulfamethizole; sulfasalazine; sulfamethoxazole; sulfonamide antibiotic; ARO_category "UPDATED category_aro_description with Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. " 901 UPDATE LCR-1 LCR beta-lactamase; penam; cephalosporin; antibiotic inactivation; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LCR-1 is a class D beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with X56809.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3262 UPDATE dfrA29 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with A dihydrofolate reductase and trimethoprim resistance gene isolated from canine Escherichia coli infection. " 3599 UPDATE GOB-13 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3598 UPDATE GOB-12 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3939 UPDATE CMY-153 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with MF042206.1 " 3938 UPDATE CMY-89 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with HE819403.1 " 3935 UPDATE CMY-128 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM985466.1 " 3934 UPDATE CMY-151 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 0 UPDATED accession with KY780116.1 UPDATED strand with - UPDATED sequence with ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCATGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGTGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA " 3937 UPDATE CMY-127 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM985465.1 " 3936 UPDATE CMY-129 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM985467.1 " 3931 UPDATE CMY-121 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM507172.1 " 3930 UPDATE SHV-216 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3933 UPDATE CMY-97 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KC007363.1 " 3932 UPDATE CMY-152 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KY978224.1 " 1703 UPDATE FosK fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATCACTGGTATCAATCACATCACCTTTTCCGTCAGGGACTTGAGCTCTTCAATCGAGTTCTATCGTGACTTGCTGGGAATGAGGCTGCACGTGACCTGGGAAGCAGGTGCTTATTTTACAGCGGGTGATACGTGGGTATGTCTGAGCGTCGGGGAACCTAAACCCGCCAACGACTACACGCATGTGGCATTCAGTGTTGGCGAAAGAGAGCTTGTTGAGCTGCACGCTAGGCTAAAAGAAGCCGGGGTTGAGGAGTGGAAGCAGAATACAAGTGAGGGTAACTCCGTGTATCTGCTTGATCCAAACGGCCATCGCATTGAGCTTCACTGCGGAACGTTGGCAACCCGCTTAGCTGAGTTGGAGAAGTCGCCCTATAAAAGGTTGGTCTGGTGCTGA UPDATED fmax with 1135 UPDATED accession with AB917040.2 UPDATED fmin with 736 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter soli UPDATED NCBI_taxonomy_id with 487316 UPDATED NCBI_taxonomy_cvterm_id with 39070 UPDATED accession with BAO79518.1 UPDATED sequence with MITGINHITFSVRDLSSSIEFYRDLLGMRLHVTWEAGAYFTAGDTWVCLSVGEPKPANDYTHVAFSVGERELVELHARLKEAGVEEWKQNTSEGNSVYLLDPNGHRIELHCGTLATRLAELEKSPYKRLVWC " 1516 UPDATE CMY-45 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-45 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with FN546177.1 " 4138 UPDATE ACT-47 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4139 UPDATE ACT-48 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1877 UPDATE CMY-12 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-12 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with Y16785.1 " 4130 UPDATE ACT-39 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4131 UPDATE ACT-40 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4132 UPDATE ACT-41 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4133 UPDATE ACT-42 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4134 UPDATE ACT-43 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4135 UPDATE ACT-44 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4136 UPDATE ACT-45 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4137 UPDATE ACT-46 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5692 UPDATE VIM-41 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5693 UPDATE VIM-44 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with From Lahey's list of beta-lactamases, no additional information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5691 UPDATE VIM-40 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5696 UPDATE VIM-47 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5697 UPDATE VIM-48 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5694 UPDATE VIM-45 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with From Lahey's list of beta-lactamases, no additional information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5695 UPDATE VIM-46 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with From Lahey's list of beta-lactamases, no additional information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3848 UPDATE PDC-68 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-68 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. " 5698 UPDATE VIM-49 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5699 UPDATE VIM-50 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4875 UPDATE OXA-546 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1063 UPDATE QnrB73 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB73 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with KF443075.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 2136 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to kanamycin A kanamycin A; antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to kanamycin A. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to kanamycin A " 1870 UPDATE OXA-66 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-66 is a beta-lactamase found in A. baumannii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3916 UPDATE CMY-122 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_048793.1 " 1065 UPDATE OXA-384 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1871 UPDATE OXA-389 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ135346.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1064 UPDATE CTX-M-141 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KC964871.1 " 301 UPDATE CMY-95 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JX514369.1 " 4044 UPDATE PDC-429 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-429 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4045 UPDATE PDC-449 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-449 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4046 UPDATE OXA-540 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_052174.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4047 UPDATE OXA-779 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_062354.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4040 UPDATE PDC-393 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-393 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4041 UPDATE PDC-119 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-119 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4042 UPDATE PDC-313 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-313 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4043 UPDATE PDC-257 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-257 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 3910 UPDATE CMY-154 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_055270.1 " 4048 UPDATE OXA-838 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with MN339504.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4049 UPDATE OXA-539 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_052064.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 447 UPDATE SHV-67 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ174307.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 7 UPDATE CTX-M-130 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JX017365.1 " 2288 UPDATE Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid isoniazid; antibiotic target alteration; antibiotic resistant ndh; model_name "UPDATED model_name with Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid " 3664 UPDATE NDM-23 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3666 UPDATE NDM-25 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3661 UPDATE NDM-20 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3660 UPDATE NDM-19 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase and NDM-1 variant. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3663 UPDATE NDM-22 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase and NDM-1 variant. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3662 UPDATE NDM-21 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase and NDM-1 variant. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2281 UPDATE Brucella suis mprF peptide antibiotic; antibiotic target alteration; defensin resistant mprF; defensin; model_sequences "UPDATED partial with 0 UPDATED sequence with TTGCTCTGGTGGGACGACATTTCGATGAGCCTGATTGATGATGAAATACCTTCTTCGCAACCGCAAGTGTCAGGTAGGCATTTCGGCTGGTTGAAACAATATCAGCATTTTCTGTTTCCAATCGCAGGCATCGCCATTGCGTTATTGGCTATTTATGTTCTGGAAAATCTTCTCAGGCACACCTCCCGCACCGAAACGCTTGCAGCCCTTCACAATATTTCATGGACGACGCTCGCACTGGCCGTCTTTTTCACAGCATTAAGCTATGCCGCAGTGGCGCTTTATGATGTCGTGGCGGTGGACACCATAGCGCCCAACCAGATACCGCGCCGCATCGCGGCGGTGGCGGGTGCTGCGGGCTATGCGATTTCCAACGCGCTCGGCTTCTCGCTCCTGACCGGCGGGGCGCTGCGTTATCGCATTTATGCCGCAGAAGGCATAAGCCTGGCCGATATCGGCAAGATCGTCGGCACCTCATGGTTCGCCATCTGGTTCGCCCTCATCATCATGGTGGGCGCAGCCCTGCTGATCGATCCGCAGGACGTGCCTTTTCTTTCCGCCATCGATATACGGATTGATATTGTCGCAGGCATTCTCATCCTTGGCGGCATTGGCTGGCTGATCTACTGGCTTTCGCATGGCGAACGCAATGTCAGCATCGGTTCGTTCAGCCTGCGCCTGCCCAATTCAAAAGGCGCGCTCACGCAGATTTTTGCGGGCGTGGTGGATGTGGGCGCTGCCGCGGCCACGCTCTATGTGCTGTTGCCGGAAGGGGCTGTGCCAAGCTTCGCCGTCTTTGCGCTCGTTTATGTCATCGCCATCGTGCTTGGCATTGCAAGCCACGCGCCAGGCGGCCTCGGCGCTTTTGAGGCAACAATCATCGCAGGGCTTGGCCTCGGTGGAAAACCCGATGCAATTGCGGGCCTGCTGGCCTATCGCCTCATTTACACGGTTCTTCCCCTCGTGGTTGCCACCGCCGGAATCCTCATCTGGGAGGTCATGCGCCGCCGCCATATGCTCGACAAGCAGGCCCGATTCGCCAAGCGGCTGGTGGAGCCGCTGGTTCCGGGGCTTTCAGCCAGCATCATCTTTCTCGGTGGCATCATCCTGCTTATCTCAGGCGCCACGCCCGATATGCGCTATCGTGTGAAGTTGCTGTCCGACATCGTGCCGGAATTTCTTGTGGAGATGTCGCATCTGGCGGCAAGCCTCGTCGGCGTTGCTCTTCTCATCGTCGCGCGCGGCCTTTCCAAACGGCTGGAGCGCGCCTGGGTGGCCGCGATGGTGCTTCTTCTTTGCGGCGCGGTGTTTTCGATCGCAAAAGGACTGGACTGGGAAGAGGCAAGCATTTTGTGCCTTTTTGCCCTTTCACTCTGGGGCTTTCGCGATTCCTTCTACCGTCGTCCGATTGCCGGCCCGTTTGAACTGAGCTGGAACTGGATCGCAACCGTTGGAACCACGGTTCTCGTGTCCACCTGGCTTGGTTTTTTCGTCTACCGCCATATCGAATATTCAAGCGATCTCTGGTGGGATTTCGCGTGGAACGGCAACGCCCCGCGTTTCCTGCGCGCCACCGTTCTGGTTTTCGCAGTCGTGGCGGCAGTCGGCCTTCATTCGATCATCAACCGGCATGGCCAGCGCAGGCGCAAGGTTGATCATTCCATCCCCGATGCCGTGCCCGCACTCGTCGCCCGGTGCCCGCATACAGATGCAGCCCTTGCCATGCTGGGCGACAAGCAATTTCTGCTGGCGCCCGACGACAGCGCGTTCATCATGTATGCGCAGTCGGGCGGCAGCCTGATCGCGCTTGGCGAGCCTATCGGCGATGCCGAAGCGGGCAAGGAACTTGCCTGGTCTTTCCATTCGCTTGCCGACCGTCTGGCGCTGCGCACTGTCTTCTATGGTGTCGGCCCGCAAAGCCTGCCGCTTTTCCTCGATATGGGCCTGATTGCGCTCAAGCTGGGTGAAGTCGCACGCGTTGACCTGACAGATTTTTCGCTGGAAGGCCCGCGCCGCCAGCCCTTCCGTTATGCCGACCGCAAGGTGGACAAGGATGGGCTGACCTTCGAGATTATCCCTGCTGCGGACGTGCCGCCGCTGATCCCGCGCCTGCGCGCAATTTCCGACGCTTGGCTCGACCATAAATCAGGCAGCGAAAAGGGTTTTTCGCTTGGCTATTTCAACGATGAGTATTTAAAGCGTTTCGATATTGCCGTGCTGAAGAAAGACGGCGAAATCGTTGCTTTCGCCAATATATGGCGCGGTGCCGACAAGTATGAGATCACGGTCGACCTGATGCGCTACATGCCCAATGTGCACAAGCTCCTGATGGATGCGCTGTTCGCCAAGCTGCTGACCTTTTCCAAGCAAGAAGGCTACAAATGGTTCAACCTTGGCGCGGCCCCGCTTTCCGGCCTTAGCGGCAGCAGGCTTGCCTCGCGCTGGAACCGTTTCGGCTCGTTCATCTATCGCCGTGGGGCCGATCTTTATCACTTCGACGGGCTCAAAGCCTTCAAGGAAAAATTCGATCCCGTCTGGACCCCGCATTATATGGTTTGCCCCGGCGGGCTTGAAACGCCGCGCGCCCTTCTTGATGCCACAACACTGATTAACGGCAGCCCTTTGGAGTTCATTCGCAAATGA UPDATED fmax with 570923 UPDATED accession with AE014292.2 UPDATED fmin with 568280 UPDATED strand with + UPDATED NCBI_taxonomy_name with Brucella suis 1330 UPDATED NCBI_taxonomy_id with 204722 UPDATED NCBI_taxonomy_cvterm_id with 36780 UPDATED accession with AAN33774.1 UPDATED sequence with MLWWDDISMSLIDDEIPSSQPQVSGRHFGWLKQYQHFLFPIAGIAIALLAIYVLENLLRHTSRTETLAALHNISWTTLALAVFFTALSYAAVALYDVVAVDTIAPNQIPRRIAAVAGAAGYAISNALGFSLLTGGALRYRIYAAEGISLADIGKIVGTSWFAIWFALIIMVGAALLIDPQDVPFLSAIDIRIDIVAGILILGGIGWLIYWLSHGERNVSIGSFSLRLPNSKGALTQIFAGVVDVGAAAATLYVLLPEGAVPSFAVFALVYVIAIVLGIASHAPGGLGAFEATIIAGLGLGGKPDAIAGLLAYRLIYTVLPLVVATAGILIWEVMRRRHMLDKQARFAKRLVEPLVPGLSASIIFLGGIILLISGATPDMRYRVKLLSDIVPEFLVEMSHLAASLVGVALLIVARGLSKRLERAWVAAMVLLLCGAVFSIAKGLDWEEASILCLFALSLWGFRDSFYRRPIAGPFELSWNWIATVGTTVLVSTWLGFFVYRHIEYSSDLWWDFAWNGNAPRFLRATVLVFAVVAAVGLHSIINRHGQRRRKVDHSIPDAVPALVARCPHTDAALAMLGDKQFLLAPDDSAFIMYAQSGGSLIALGEPIGDAEAGKELAWSFHSLADRLALRTVFYGVGPQSLPLFLDMGLIALKLGEVARVDLTDFSLEGPRRQPFRYADRKVDKDGLTFEIIPAADVPPLIPRLRAISDAWLDHKSGSEKGFSLGYFNDEYLKRFDIAVLKKDGEIVAFANIWRGADKYEITVDLMRYMPNVHKLLMDALFAKLLTFSKQEGYKWFNLGAAPLSGLSGSRLASRWNRFGSFIYRRGADLYHFDGLKAFKEKFDPVWTPHYMVCPGGLETPRALLDATTLINGSPLEFIRK " 2284 UPDATE Escherichia coli murA with mutation conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant murA transferase; model_sequences "UPDATED accession with CP009072.1 UPDATED accession with AIL15701.1 " 3668 UPDATE NDM-27 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase and NDM-1 variant. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2287 UPDATE Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid isoniazid; antibiotic target alteration; antibiotic resistant ndh; model_name "UPDATED model_name with Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid " 446 UPDATE catB8 antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with catB8 is a plasmid or integron-encoded variant of the cat gene found in Klebsiella pneumoniae, Salmonella typhi and Pseudomonas aeruginosa. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 974 UPDATE lmrC celesticetin; pleuromutilin antibiotic; macrolide antibiotic; lincomycin; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; clindamycin; phenicol antibiotic; lincosamide antibiotic; ARO_description "UPDATED ARO_description with lmrC is an ABC-F subfamily protein that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD. " 4828 UPDATE OXA-396 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2762 UPDATE MexMN-OprM antibiotic efflux; thiamphenicol; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; phenicol antibiotic; chloramphenicol; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 3268 UPDATE Clostridioides difficile gyrB conferring resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrB; ARO_description; model_name "UPDATED ARO_description with Point mutations in gyrB of Clostridioides difficile conferring resistance to fluoroquinolone antibiotics. UPDATED model_name with Clostridioides difficile gyrB conferring resistance to fluoroquinolones " 2056 UPDATE mdtO antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; puromycin; acriflavine; nucleoside antibiotic; disinfecting agents and antiseptics; ARO_description; ARO_category "UPDATED ARO_description with Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 2059 UPDATE OKP-A-1 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCCGCCGCTTGAGCAAATTACACGCAGCGAAAGTCAGCTGGCGGGCCGCGTGGGCTATGTTGAAATGGATCTGGTCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAATGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGAGACGAACAGCTGGATCGGCGGATCCGCTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTTGGCGGCCCCGCTGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAGCTCAATGAAGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCAGCCAGCATGGCCGCCACCCTGCGCAAGCTGCTAACCAGCCACACTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCAGGTAGCCGGTCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGAAAAAACCGGGGCCGGCGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGAACGGCAAAGCGGAGCGCATCGTGGTGATCTATCTGCGGGATACGCCGGCGTCCATGGCCGAGCGTAACCAGCAGATCGCCAGAATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAG UPDATED fmax with 861 UPDATED accession with AJ635401.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAG25812.2 UPDATED sequence with MRYVRLCLISLIAALPLAVFASPPPLEQITRSESQLAGRVGYVEMDLVSGRTLAAWRANERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIRYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMAATLRKLLTSHTLSARSQQQLLQWMVDDQVAGPLIRAVLPAGWFIAEKTGAGERGSRGIVALLGPNGKAERIVVIYLRDTPASMAERNQQIARIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 2378 UPDATE Escherichia coli cyaA with mutation conferring resistance to fosfomycin antibiotic-resistant cya adenylate cyclase; fosfomycin; antibiotic target alteration; model_sequences "UPDATED accession with HG738867.1 UPDATED accession with CDJ73082.1 " 2379 UPDATE Escherichia coli cyaA with mutation conferring resistance to fosfomycin antibiotic-resistant cya adenylate cyclase; fosfomycin; antibiotic target alteration; model_sequences "UPDATED accession with HG738867.1 UPDATED accession with CDJ73082.1 " 4827 UPDATE OXA-395 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2374 UPDATE Escherichia coli UhpA with mutation conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant UhpT; model_sequences; ARO_name "UPDATED accession with HG738867.1 UPDATED accession with CDJ73205.1 UPDATED ARO_name with Escherichia coli uhpA with mutation conferring resistance to fosfomycin " 2375 UPDATE Rm3 Rm3 family beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; penam; ARO_category; model_name "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with Rm3 " 2376 UPDATE Escherichia coli UhpA with mutation conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant UhpT; model_sequences; ARO_name "UPDATED accession with HG738867.1 UPDATED accession with CDJ73205.1 UPDATED ARO_name with Escherichia coli uhpA with mutation conferring resistance to fosfomycin " 4927 UPDATE OXA-601 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2372 UPDATE Escherichia coli GlpT with mutation conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant GlpT; model_sequences "UPDATED accession with HG738867.1 UPDATED accession with CDJ72593.1 " 2373 UPDATE Escherichia coli UhpT with mutation conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant UhpT; model_sequences "UPDATED accession with HG738867.1 UPDATED accession with CDJ73208.1 " 3593 UPDATE FRI-2 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3592 UPDATE FRI-1 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3591 UPDATE FPH-1 penam; antibiotic inactivation; FPH beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3590 UPDATE FONA-6 penam; antibiotic inactivation; FONA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3597 UPDATE GOB-11 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3596 UPDATE GOB-10 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3595 UPDATE FTU-1 penam; antibiotic inactivation; FTU beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3594 UPDATE FRI-3 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5036 UPDATE OXA-726 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5037 UPDATE OXA-727 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5034 UPDATE OXA-722 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5035 UPDATE OXA-723 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5032 UPDATE OXA-720 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5033 UPDATE OXA-721 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5030 UPDATE OXA-718 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5031 UPDATE OXA-719 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1876 UPDATE LEN-7 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with LEN-7 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4434 UPDATE CARB-50 penam; antibiotic inactivation; CARB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1874 UPDATE OXA-196 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ425494.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1875 UPDATE MIR-11 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087859.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 4431 UPDATE CARB-47 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4430 UPDATE CARB-46 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4433 UPDATE CARB-49 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4432 UPDATE CARB-48 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 600 UPDATE CMY-2 penam; carbapenem; cephalosporin; cefazolin; ceftazidime; cefalotin; cephamycin; antibiotic inactivation; cefixime; amoxicillin; ampicillin; clavulanic acid; CMY beta-lactamase; ceftriaxone; cefoxitin; amoxicillin-clavulanic acid; ertapenem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CMY-2 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with X91840.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4439 UPDATE CARB-55 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4438 UPDATE CARB-54 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1878 UPDATE SRT-2 antibiotic inactivation; cephalosporin; SRT beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with SRT-2, isolated from Serratia marcescens, is a chromosomal beta-lactamase that confers resistance to cefotaxime. UPDATED partial with 0 UPDATED sequence with ATGACGAAAATGAACCGCCTGGCGGCCGCGCTGATCGCCGCACTGATCTTGCCGACCGCGCAGGCCGCGCAGCAGCAGGATATCGACGCCGTTATTCAGCCGCTGATGAAAAAATATGGCGTACCGGGCATGGCGATCGCCGTGTCGGTCGACGGCAAACAGCAGATTTACCCGTATGGCGTCGCCTCGAAGCAGACCGGCAAACCGATCACCGAGGAGACGCTGTTCGAAGTGGGCTCGCTGAGCAAAACCTTTACCGCGACGCTGGCGGTCTATGCGCAGCAGCAGGGCAAGCTGTCGTTCAACGATCCGGCCAGCCGCTATCTGCCCGAGCTGCGCGGCAGCGCCTTCGACGGCGTCAGCCTGCTGAATCTGGCGACGCATACCTCCGGCCTGCCGCTGTTCGTGCCGGACGACGTCACTAACGACGCCCAGCTGATGGCCTACTACCGGGCCTGGCAGCCGAAACACCCGGCGGGCAGCTACCGTGTCTATTCCAACCTCGGCATCGGCATGCTGGGCATGATCGCCGCCAAGAGCCTCGACCAGCCGTTTATCCAGGCGATGGAACAGGGGATGCTGCCGGCGCTGGGCATGAGCCACACCTACGTTCAGGTGCCGGCGGCGCAGATGGCTAACTATGCGCAGGGTTACAGCAAGGACGATAAGCCGGTGCGGGTCAACCCCGGCCCGCTGGATGCCGAGTCTTACGGCATCAAGTCCAACGCTCGCGATCTGATTCGCTATCTGGACGCCAACCTGCAGCAGGTGAAGGTGGCGCAGCCGTGGCGCGACGCGCTGGCCGCGACGCACGTCGGGTATTACAAGGCGGGCGCGTTCACGCAGGATCTGATGTGGGAGAACTACCCGTATCCGGTGAAACTGTCGCGTTTGATTGAAGGCAACAACGCCGGGATGATCATGAACGGCACGCCGGCCACCGCCATCACGCCGCCGCAGCCGGAATTGCGCGCCGGCTGGTATAACAAAACCGGCTCCACCGGCGGCTTCTCCACCTACGCGGTATTTATCCCGGCGAAAAATATCGCCGTGGTGATGCTGGCCAACAAGTGGTTCCCGAACGACGATCGCGTCGAGGCGGCTTACCACATCGTCCAGGCGCTGGAGAAGCGCTGA UPDATED fmax with 1137 UPDATED accession with AY524276.3 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Serratia marcescens UPDATED NCBI_taxonomy_id with 615 UPDATED NCBI_taxonomy_cvterm_id with 36783 UPDATED accession with AAS07017.3 UPDATED sequence with MTKMNRLAAALIAALILPTAQAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEETLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTSGLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKSNARDLIRYLDANLQQVKVAQPWRDALAATHVGYYKAGAFTQDLMWENYPYPVKLSRLIEGNNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLANKWFPNDDRVEAAYHIVQALEKR " 1879 UPDATE AAC(3)-IIIa antibiotic inactivation; aminoglycoside antibiotic; gentamicin C; AAC(3); gentamicin B; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-IIIa is a chromosomal-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with X55652.1 " 977 UPDATE OXA-112 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-112 is a beta-lactamase found in A. baumannii. UPDATED accession with EF650038.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 976 UPDATE CTX-M-61 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-61 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with EF219142.1 " 975 UPDATE QnrB1 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; ARO_category "UPDATED ARO_description with QnrB1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4946 UPDATE OXA-620 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 973 UPDATE OXA-378 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 972 UPDATE CMY-23 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-23 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with DQ463751.1 " 971 UPDATE cmlA4 antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmlA4 is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella pneumoniae. UPDATED accession with AF156486.1 " 970 UPDATE OKP-B-18 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-18 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM850920.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 596 UPDATE ROB-1 penam; antibiotic inactivation; cephalosporin; ROB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ROB-1 is a beta-lactamase found in Pasteurella and Haemophilus. UPDATED accession with X52872.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4949 UPDATE OXA-623 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4948 UPDATE OXA-622 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 979 UPDATE TEM-96 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY092401.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 978 UPDATE OXA-134 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-134 is a beta-lactamase found in A. lwoffii. UPDATED accession with HQ122933.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 182 UPDATE arlS antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 183 UPDATE adeS antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; tetracycline antibiotic; tetracycline; model_sequences "UPDATED accession with HM440348.1 " 180 UPDATE DHA-19 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087849.1 " 181 UPDATE GES-14 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-14 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with GU207844.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 186 UPDATE OXA-12 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-12 is a beta-lactamase found in Aeromonas jandaei. UPDATED accession with U10251.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 187 UPDATE OXA-348 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297577.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 184 UPDATE OCH-1 penam; antibiotic inactivation; penem; cephalosporin; cephamycin; monobactam; OCH beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OCH-1 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. UPDATED accession with AJ401618.1 UPDATED NCBI_taxonomy_name with Brucella anthropi UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. " 185 UPDATE OXA-232 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-232 is a beta-lactamase found in Enterobacteriaceae. UPDATED accession with JX423831.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2110 UPDATE CARB-20 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with CARB-20 is a beta-lactamase found worldwide in Vibrio parahaemolyticus. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 188 UPDATE SHV-89 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ193536.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 189 UPDATE CTX-M-19 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-19 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AF325134.1 " 2114 UPDATE APH(3')-IIa antibiotic inactivation; aminoglycoside antibiotic; paromomycin; APH(3'); gentamicin B; ribostamycin; G418; neomycin; butirosin; ARO_description; ARO_category "UPDATED ARO_description with APH(3')-IIa is a transposon-encoded aminoglycoside phosphotransferase in E. coli. UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 2115 UPDATE TEM-4 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2116 UPDATE Pasteurella multocida 16S rRNA mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutations in the helix 34 region of 16S rRNA of Pasteurella multocida can confer resistance to spectinomycin. " 1559 UPDATE mtrA penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; penicillin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4820 UPDATE OXA-114u carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4089 UPDATE KPC-25 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-25 [Klebsiella pneumoniae] Accession: WP_065419571.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1919 UPDATE SHV-27 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF293345.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1918 UPDATE spd antibiotic inactivation; aminoglycoside antibiotic; spectinomycin; ANT(9); ARO_description; model_sequences; ARO_category "UPDATED ARO_description with spd is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in S. aureus. UPDATED accession with KC895984.1 UPDATED category_aro_description with Nucleotidylylation of spectinomycin at the hydroxyl group at position 9. " 5108 UPDATE OXA-803 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5109 UPDATE OXA-804 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 602 UPDATE VIM-16 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-16 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with EU419746.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4924 UPDATE OXA-598 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3286 UPDATE Klebsiella pneumoniae KpnF peptide antibiotic; triclosan; major facilitator superfamily (MFS) antibiotic efflux pump; chlorhexidine; antibiotic efflux; aminoglycoside antibiotic; rifamycin antibiotic; colistin A; macrolide antibiotic; colistin B; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cefepime; benzalkonium chloride; tetracycline antibiotic; rifampin; streptomycin; ceftriaxone; disinfecting agents and antiseptics; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with triclosan UPDATED category_aro_cvterm_id with 37250 UPDATED category_aro_accession with 3000870 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Triclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI). UPDATED category_aro_name with chlorhexidine UPDATED category_aro_cvterm_id with 45598 UPDATED category_aro_accession with 3007039 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate). UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED category_aro_name with benzalkonium chloride UPDATED category_aro_cvterm_id with 40514 UPDATED category_aro_accession with 3003823 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent. " 5101 UPDATE OXA-796 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3283 UPDATE Klebsiella pneumoniae KpnE peptide antibiotic; triclosan; major facilitator superfamily (MFS) antibiotic efflux pump; chlorhexidine; antibiotic efflux; aminoglycoside antibiotic; rifamycin antibiotic; colistin A; macrolide antibiotic; colistin B; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cefepime; benzalkonium chloride; tetracycline antibiotic; rifampin; streptomycin; ceftriaxone; disinfecting agents and antiseptics; tetracycline; erythromycin; ARO_description; ARO_category "UPDATED ARO_description with KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. UPDATED category_aro_name with triclosan UPDATED category_aro_cvterm_id with 37250 UPDATED category_aro_accession with 3000870 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Triclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI). UPDATED category_aro_name with chlorhexidine UPDATED category_aro_cvterm_id with 45598 UPDATED category_aro_accession with 3007039 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate). UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED category_aro_name with benzalkonium chloride UPDATED category_aro_cvterm_id with 40514 UPDATED category_aro_accession with 3003823 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent. " 1914 UPDATE BEL-3 penam; monobactam; cephalosporin; antibiotic inactivation; BEL beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with BEL-3 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with GQ202694.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3281 UPDATE Acinetobacter baumannii AbuO penam; antibiotic efflux; amikacin; chlorhexidine; resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; benzalkonium chloride; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; tigecycline; glycylcycline; carbenicillin; tetracycline antibiotic; streptomycin; ceftriaxone; disinfecting agents and antiseptics; meropenem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with chlorhexidine UPDATED category_aro_cvterm_id with 45598 UPDATED category_aro_accession with 3007039 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate). UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 3280 UPDATE Acinetobacter baumannii AmvA antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; disinfecting agents and antiseptics; erythromycin; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 869 UPDATE CRP penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; cloxacillin; fluoroquinolone antibiotic; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 868 UPDATE DHA-1 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; ARO_description "UPDATED ARO_description with DHA-1 is a class C beta-lactamase found in Morganella morganii and Salmonella enterica. " 2113 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; tobramycin; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' minor domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tobramycin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin " 3449 UPDATE OXA-284 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3448 UPDATE OXA-283 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 861 UPDATE OXA-215 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN861783.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 860 UPDATE TEM-42 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with X98047.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 863 UPDATE PER-7 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with PER-7 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with HQ713678.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3446 UPDATE OXA-281 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3441 UPDATE OXA-275 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 864 UPDATE CMY-61 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JF460795.1 " 867 UPDATE OXA-175 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-175 is a beta-lactamase found in A. baumannii. UPDATED accession with HM113561.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2756 UPDATE NDM-17 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KX812714.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2025 UPDATE TEM-57 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ405211.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2026 UPDATE OXA-84 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-84 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ309276.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2027 UPDATE CMY-84 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ733579.1 " 2752 UPDATE ANT(3'')-IIa antibiotic inactivation; ANT(3''); aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 2753 UPDATE HMB-1 carbapenem; antibiotic inactivation; HMB beta-lactamase; model_sequences; model_name "UPDATED partial with 0 UPDATED sequence with ATGAAAATACATTTATGGATATCATTGGGTCTTTTGCTGCTGACAAACATCGTTCTTGCAGAAGAACCGCTACCCGAACTGGAAGTTAAAAAAATCGATGAGGGTGTTTATCTGCATACGTCCTATGAAAATTATCCAAGCTGGGGCTTGGTTGCATCCCACGGTTTGGTTTTTGTGGATGGTAAAGACGCTTACATTATTGATACACCCGCTACTGTTAAAGACACAGAAGTGTTAGTGCAATGGATTAACGATCAAGGCTTCAAACCCAAGGCCAGCATTTCTACGCACTTTCACGATGACAGCACCATCGGCATTGCCTACTTAAATTCCAAATCCATTCCGACCTACGCATCAGAACAAACTAATGAATTGCTTAATAAAGAAGTCGCTGCACAGGCAACGCATTCGTTTAAGAAAAATCCTTATTGGCTGTTAAAAAATAAAATCGAAGCTTTTTATCCGGGCGCTGGCCACACGCCTGACAATTTAGTGGTGTGGTTGCCGAAGCAGAAAATTCTATTCGGTGGCTGTTTTGTAAAACCCGAAGGGCTGGGAAATTTAAGCCATGCGGTAGTTTCTGAATGGCCTGCTTCTGCAGAAAAACTTATCAATCGCTATAGCGACGCAAAAATCGTAGTACCGGGTCATGGAACAATGGGCGATGCATCGCTGCTGGAAAAAACCAAACAGCGTGCGCTTGAGGCGGTTGCAAAGAAGAAATAA UPDATED fmax with 2757 UPDATED accession with KU961660.2 UPDATED fmin with 2031 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AMY61250.1 UPDATED sequence with MKIHLWISLGLLLLTNIVLAEEPLPELEVKKIDEGVYLHTSYENYPSWGLVASHGLVFVDGKDAYIIDTPATVKDTEVLVQWINDQGFKPKASISTHFHDDSTIGIAYLNSKSIPTYASEQTNELLNKEVAAQATHSFKKNPYWLLKNKIEAFYPGAGHTPDNLVVWLPKQKILFGGCFVKPEGLGNLSHAVVSEWPASAEKLINRYSDAKIVVPGHGTMGDASLLEKTKQRALEAVAKKK UPDATED model_name with HMB-1 " 2022 UPDATE CTX-M-104 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-104 is a beta-lactamase found in Escherichia coli. UPDATED accession with HQ833652.1 " 2023 UPDATE OXA-132 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-132 is a beta-lactamase found in A. baumannii. UPDATED accession with EU547447.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 938 UPDATE QnrB70 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB70 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with KC580659.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 2828 UPDATE mecD penam; methicillin resistant PBP2; methicillin; antibiotic target replacement; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2117 UPDATE AAC(6')-Ib7 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii. " 2028 UPDATE QnrB43 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; ARO_category "UPDATED ARO_description with QnrB43 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 2029 UPDATE TEM-123 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY327539.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 883 UPDATE LRA-17 penam; antibiotic inactivation; subclass B3 LRA beta-lactamase; cephalosporin; ARO_description; ARO_category "UPDATED ARO_description with LRA-17 is a beta-lactamase isolated from soil samples in Alaska. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 882 UPDATE RCP-1 penam; antibiotic inactivation; RCP beta-lactamase; model_sequences; ARO_category "UPDATED accession with X15791.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 881 UPDATE ErmC antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with M12730.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 880 UPDATE APH(6)-Ib antibiotic inactivation; APH(6); streptomycin; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(6)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. glaucescens. UPDATED accession with X05648.1 UPDATED category_aro_description with Phosphorylation of streptomycin on the hydroxyl group at position 6. " 887 UPDATE SHV-33 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX268631.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 886 UPDATE IND-10 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-10 is a beta-lactamase found in Escherichia coli. UPDATED accession with GU206353.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 885 UPDATE TEM-63 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF332513.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 884 UPDATE CTX-M-99 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-99 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with HM803271.1 " 889 UPDATE CMY-74 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JX440349.1 " 888 UPDATE Erm(36) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with AF462611.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 1340 UPDATE mtrC penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; penicillin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5216 UPDATE OXA-925 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5217 UPDATE OXA-927 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5214 UPDATE OXA-923 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5215 UPDATE OXA-924 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5212 UPDATE OXA-921 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5213 UPDATE OXA-922 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5210 UPDATE OXA-919 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5211 UPDATE OXA-920 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5218 UPDATE OXA-928 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5219 UPDATE OXA-929 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5682 UPDATE VEB-21 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 418 UPDATE OXA-325 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203099.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 353 UPDATE QnrB2 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB2 is a plasmid-mediated quinolone resistance protein found in Citrobacter koseri. UPDATED accession with EF488762.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 352 UPDATE PDC-5 penam; carbapenem; monobactam; cephalosporin; cefazolin; ampicillin; ceftazidime; cefalotin; cephamycin; antibiotic inactivation; amoxicillin; PDC beta-lactamase; clavulanic acid; cefixime; ceftriaxone; cefoxitin; amoxicillin-clavulanic acid; model_sequences; ARO_category "UPDATED accession with FJ666068.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 775 UPDATE CMY-113 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM087836.1 " 774 UPDATE tet37 tetracycline antibiotic; antibiotic inactivation; tetracycline inactivation enzyme; tetracycline; ARO_description; model_sequences "UPDATED ARO_description with tet37 is a chromosome-encoded oxidoreductase isolated from an uncultured bacterium that confers resistance to tetracycline. UPDATED accession with AF540889.1 " 776 UPDATE tetX antibiotic inactivation; tetracycline; chlortetracycline; demeclocycline; oxytetracycline; tetracycline antibiotic; tigecycline; glycylcycline; minocycline; tetracycline inactivation enzyme; doxycycline; model_sequences "UPDATED accession with M37699.1 " 771 UPDATE CMY-24 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-24 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with EF415650.1 " 770 UPDATE SHV-57 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY223863.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 773 UPDATE OCH-4 penam; antibiotic inactivation; penem; cephalosporin; cephamycin; monobactam; OCH beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OCH-4 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. UPDATED accession with AJ295342.1 UPDATED NCBI_taxonomy_name with Brucella anthropi UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. " 772 UPDATE LEN-6 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences; ARO_category "UPDATED accession with AY265890.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4596 UPDATE ECM-1 carbapenem; ECM beta-lactamase; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 779 UPDATE OXA-350 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297579.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 778 UPDATE IMP-25 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-25 is a beta-lactamase found in Serratia marcescens. UPDATED accession with EU541448.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 77 UPDATE TEM-47 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y10279.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 76 UPDATE SHV-79 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGTGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATCGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 891 UPDATED accession with AM176554.2 UPDATED fmin with 30 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47134.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEVLPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 75 UPDATE fusH antibiotic inactivation; fusidic acid; fusidic acid inactivation enzyme; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with fusH is a highly specific fusidic acid esterase found in Streptomyces lividans. UPDATED accession with Z50108.1 UPDATED category_aro_description with Enzymes that confer resistance to fusidic acid by inactivation. " 74 UPDATE SHV-18 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF132290.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 73 UPDATE OXA-35 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-35 is a beta-lactamase found in P. aeruginosa. UPDATED accession with AF315786.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 72 UPDATE SHV-42 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF535130.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 71 UPDATE QnrB66 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB66 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with KC580655.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 70 UPDATE NDM-10 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF361506.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 79 UPDATE VIM-37 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-37 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with JX982636.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 78 UPDATE TEM-16 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with X65254.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1042 UPDATE Pseudomonas aeruginosa catB7 antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1041 UPDATE MexS antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; trimethoprim; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; ciprofloxacin; fluoroquinolone antibiotic; phenicol antibiotic; chloramphenicol; model_sequences "UPDATED accession with HQ433550.1 " 1040 UPDATE OXA-95 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-95 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ519089.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1047 UPDATE catS antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with catS is a chromosome-encoded variant of the cat gene found in Streptococcus pyogenes. UPDATED accession with X74948.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1046 UPDATE vgaD dalfopristin; pleuromutilin; virginiamycin M1; pleuromutilin antibiotic; madumycin II; griseoviridin; ABC-F ATP-binding cassette ribosomal protection protein; macrolide antibiotic; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; model_sequences; ARO_category "UPDATED accession with GQ205627.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 1045 UPDATE ErmO-srmA antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; model_name "UPDATED model_name with ErmO-srmA " 1044 UPDATE CTX-M-22 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-22 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY080894.1 " 4597 UPDATE ECV-1 carbapenem; antibiotic inactivation; ECV beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1048 UPDATE QnrB33 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB33 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. UPDATED accession with JN173055.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 266 UPDATE QnrB13 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB13 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with EU273755.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 2785 UPDATE Klebsiella pneumoniae OmpK37 penam; carbapenem; penem; reduced permeability to antibiotic; cefotaxime; cephalosporin; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; cefoxitin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1681 UPDATE APH(4)-Ib antibiotic inactivation; hygromycin B; aminoglycoside antibiotic; APH(4); ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(4)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in Pseudomonas pseudomallei. UPDATED accession with X74325.1 UPDATED category_aro_description with Phosphorylation of hygromycin on the hydroxyl group at position 4. " 1680 UPDATE macA efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; macrolide antibiotic; erythromycin; model_sequences "UPDATED accession with AY768531.1 " 1683 UPDATE QnrB67 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB67 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. UPDATED accession with KC580656.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1682 UPDATE aadA24 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; model_sequences; ARO_category "UPDATED accession with DQ677333.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1685 UPDATE SHV-40 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF535128.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1684 UPDATE LEN-18 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-18 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTTTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGGTCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGCTCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM850908.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12346.2 UPDATED sequence with MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTVGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVLYLRDTPASMAERNQHIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1687 UPDATE cphA3 carbapenem; CphA beta-lactamase; antibiotic inactivation; model_sequences; model_name "UPDATED accession with AY112998.1 UPDATED model_name with cphA3 " 1725 UPDATE TEM-101 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF495873.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1689 UPDATE vanRO glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_name; ARO_name "UPDATED ARO_description with Also known as vanRO, is a vanR variant found in the vanO gene cluster. UPDATED model_name with vanR gene in vanO cluster UPDATED ARO_name with vanR gene in vanO cluster " 1688 UPDATE CTX-M-90 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-90 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with FJ907381.1 " 358 UPDATE QnrB42 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB42 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. UPDATED accession with JN680743.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1269 UPDATE OXA-192 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JF273470.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1268 UPDATE CMY-115 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM087839.1 " 669 UPDATE MIR-12 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087863.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 667 UPDATE ACT-1 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACT-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATGAGGGTCAGCCGCACTACTTCACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACTCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGTGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCAAGGATAACGCCTCTCTGTTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCAGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTTGCACTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCAGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG UPDATED fmax with 1173 UPDATED accession with U58495.2 UPDATED fmin with 27 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAC45086.2 UPDATED sequence with MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1262 UPDATE SHV-149 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121116.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 663 UPDATE ACT-36 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KM926621.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1266 UPDATE ANT(4')-IIa antibiotic inactivation; aminoglycoside antibiotic; ribostamycin; paromomycin; kanamycin A; gentamicin B; lividomycin B; ANT(4'); lividomycin A; isepamicin; G418; neomycin; tobramycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ANT(4')-IIa is a plasmid-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa and Enterobacteriaceae. UPDATED accession with M98270.1 UPDATED category_aro_description with Nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 4'. " 1265 UPDATE MIR-4 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with MIR-4 is a beta-lactamase found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTTCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCACGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAAGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTAGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA UPDATED fmax with 1175 UPDATED accession with EF417572.2 UPDATED fmin with 29 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ABN69112.2 UPDATED sequence with MMTKSLSCALLLSVASAAFAAPMFEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 660 UPDATE Streptococcus pneumoniae parC conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutation in Streptococcus pneumoniae parC resulting in fluoroquinolone resistance. UPDATED model_name with Streptococcus pneumoniae parC conferring resistance to fluoroquinolones " 5102 UPDATE OXA-797 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5103 UPDATE OXA-798 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5100 UPDATE OXA-795 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 67 UPDATE OXA-391 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ427797.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1912 UPDATE LRA-13 penam; antibiotic inactivation; cephalosporin; class D LRA beta-lactamase; class C LRA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2138 UPDATE NmcA penam; carbapenem; NmcA beta-lactamase; cefazolin; cephalosporin; antibiotic inactivation; cephamycin; amoxicillin; ampicillin; clavulanic acid; cefoxitin; amoxicillin-clavulanic acid; model_sequences; model_name; ARO_category "UPDATED accession with Z21956.1 UPDATED model_name with NmcA UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5106 UPDATE OXA-801 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 577 UPDATE QnrB65 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB65 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with KC580654.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 5107 UPDATE OXA-802 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1111 UPDATE AAC(6')-Ig AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ig is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter haemolyticus. UPDATED accession with L09246.1 " 1469 UPDATE facT antibiotic efflux; factumycin; elfamycin antibiotic; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; ARO_description; model_sequences "UPDATED ARO_description with Efflux protein facT confers resistance to factumycin. The gene has been heterologously expressed in S. coelicolor and its function confirmed. It is possible that this gene can export other kirromycin-like elfamycins, but this has not been tested. UPDATED accession with JQ768046.1 UPDATED NCBI_taxonomy_name with Streptomyces sp. WAC05292 " 1917 UPDATE tet(30) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AF090987.1 " 520 UPDATE AcrS penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; cephamycin; tigecycline; glycylcycline; ciprofloxacin; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; model_sequences; model_name; ARO_category "UPDATED accession with U00096.1 UPDATED model_name with AcrS UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1467 UPDATE LEN-22 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-22 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCCCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGACAAGACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM850912.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12350.2 UPDATED sequence with MRYVRLCVISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSPRSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1916 UPDATE TEM-208 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC865667.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1461 UPDATE SHV-63 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU342351.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1823 UPDATE OXY-1-3 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-1-3 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AY077482.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1463 UPDATE GES-19 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-19 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with JN596280.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1019 UPDATE IMP-21 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with AB204557.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1317 UPDATE CTX-M-3 penam; antibiotic inactivation; cephalosporin; cefazolin; ceftazidime; cefalotin; cephamycin; amoxicillin; ampicillin; clavulanic acid; cefixime; ceftriaxone; cefoxitin; amoxicillin-clavulanic acid; CTX-M beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CTX-M-3 is a beta-lactamase found in Citrobacter freundii. UPDATED accession with Y10278.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1316 UPDATE Pseudomonas aeruginosa catB6 antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; model_name; ARO_category "UPDATED ARO_description with catB6 is a plasmid-encoded variant of the cat gene found in Pseudomonas aeruginosa. UPDATED accession with AJ223604.1 UPDATED model_name with Pseudomonas aeruginosa catB6 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1315 UPDATE mdtC efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; aminocoumarin antibiotic; resistance-nodulation-cell division (RND) antibiotic efflux pump; novobiocin; model_sequences "UPDATED accession with U00096.1 " 1314 UPDATE OXA-214 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN861782.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2092 UPDATE Klebsiella aerogenes acrR with mutation conferring multidrug antibiotic resistance penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1312 UPDATE OXA-111 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-111 is a beta-lactamase found in A. baumannii. UPDATED accession with EF650037.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1311 UPDATE OXY-5-2 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-5-2 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ871871.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1310 UPDATE IMP-10 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-10 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AB074433.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3276 UPDATE Staphylococcus aureus LmrS antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim; macrolide antibiotic; chloramphenicol; kanamycin A; linezolid; diaminopyrimidine antibiotic; florfenicol; oxazolidinone antibiotic; streptomycin; aminoglycoside antibiotic; phenicol antibiotic; erythromycin; ARO_description "UPDATED ARO_description with MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid. " 1319 UPDATE SHV-147 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121114.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1318 UPDATE evgS penam; antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; tetracycline antibiotic; cloxacillin; fluoroquinolone antibiotic; tetracycline; erythromycin; model_sequences; ARO_category "UPDATED accession with U00096.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1403 UPDATE OXA-388 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ135343.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1430 UPDATE SHV-125 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ390807.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4608 UPDATE FRI-10 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 528 UPDATE OCH-8 penam; antibiotic inactivation; penem; cephalosporin; cephamycin; monobactam; OCH beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OCH-8 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. UPDATED accession with DQ489307.1 UPDATED NCBI_taxonomy_name with Brucella anthropi UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. " 5097 UPDATE OXA-789 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1011 UPDATE TEM-29 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y17584.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3445 UPDATE OXA-280 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4609 UPDATE GES-25 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, not yet released. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 3444 UPDATE OXA-279 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 22 UPDATE ACT-10 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with JN848330.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1404 UPDATE IMP-3 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-3 is a beta-lactamase found in Acinetobacter baumannii. UPDATED accession with AB010417.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3447 UPDATE OXA-282 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3948 UPDATE SHV-208 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly added to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3949 UPDATE SHV-206 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 319 UPDATE OXA-366 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP050485.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 862 UPDATE IMP-16 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-16 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AJ584652.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 313 UPDATE OXA-143 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-143 is a beta-lactamase found in A. baumannii. UPDATED accession with GQ861437.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3941 UPDATE CMY-144 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KY066478.1 " 311 UPDATE IND-2 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-2 is a beta-lactamase found in Chryseobacterium indologenes. UPDATED accession with AF219127.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 310 UPDATE SHV-78 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCAGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 891 UPDATED accession with AM176553.2 UPDATED fmin with 30 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47133.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASSRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3944 UPDATE OXA-544 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_068180.1 UPDATED accession with WP_071537493.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 316 UPDATE CTX-M-36 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-36 is a beta-lactamase found in Escherichia coli. UPDATED accession with AB177384.1 " 315 UPDATE DHA-2 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with DHA-2 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AF259520.1 " 3440 UPDATE OXA-273 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4606 UPDATE FOX-16 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_category "UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 448 UPDATE dfrG trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrG is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. UPDATED accession with AB205645.1 " 3443 UPDATE OXA-277 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1339 UPDATE Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol antibiotic target alteration; ethambutol resistant embR; ethambutol; polyamine antibiotic; ARO_description; ARO_category "UPDATED ARO_description with Point mutation in the M.tuberculosis embR results in increased resistance to ethambutol. UPDATED category_aro_description with Mutations that occurs on the embR genes resulting in the resistance to ethambutol. " 3442 UPDATE OXA-276 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1338 UPDATE Bla1 penam; class A Bacillus anthracis Bla beta-lactamase; antibiotic inactivation; model_sequences; model_name; ARO_category "UPDATED accession with AY453161.1 UPDATED model_name with Bla1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2024 UPDATE ACC-2 penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACC-2 is a beta-lactamase found in Hafnia alvei. UPDATED accession with AF180952.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4129 UPDATE ACT-34 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4128 UPDATE ACC-8 penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4123 UPDATE ACC-1a penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4127 UPDATE ACC-7 penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2754 UPDATE ANT(3'')-IIb antibiotic inactivation; ANT(3''); aminoglycoside antibiotic; model_sequences; ARO_category "UPDATED accession with ENU91137.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 4125 UPDATE ACC-1c penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4124 UPDATE ACC-1b penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 443 UPDATE OKP-B-10 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-10 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051160.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 659 UPDATE AAC(6')-29b AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(6')-29b is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. " 2755 UPDATE ANT(3'')-IIc antibiotic inactivation; ANT(3''); aminoglycoside antibiotic; model_sequences; ARO_category "UPDATED accession with ENU37733.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 5688 UPDATE VEB-27 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 442 UPDATE OpmD antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and antiseptics; tetracycline; ARO_category; model_name "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 UPDATED model_name with OpmD " 5685 UPDATE VEB-24 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 5687 UPDATE VEB-26 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 5686 UPDATE VEB-25 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 5681 UPDATE VEB-20 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 441 UPDATE OXA-54 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY500137.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5683 UPDATE VEB-22 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 2021 UPDATE SHV-165 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121131.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2323 UPDATE qacH efflux pump complex or subunit conferring antibiotic resistance; small multidrug resistance (SMR) antibiotic efflux pump; disinfecting agents and antiseptics; antibiotic efflux; ARO_description; ARO_category "UPDATED ARO_description with qacH is a subunit of the qac multidrug efflux pump in Staphylococcus saprophyticus. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 440 UPDATE MexA sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; nalidixic acid; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; trimethoprim; azithromycin; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2750 UPDATE APH(3')-VIIIb antibiotic inactivation; APH(3'); aminoglycoside antibiotic; G418; neomycin; model_sequences; model_name; ARO_category "UPDATED accession with EPF73263.1 UPDATED model_name with APH(3')-VIIIb UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 2751 UPDATE APH(3')-IX antibiotic inactivation; APH(3'); aminoglycoside antibiotic; G418; neomycin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Acinetobacter gerneri DSM 14967 = CIP 107464 = MTCC 9824 UPDATED accession with ENV34035.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 4604 UPDATE FOX-14 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_category "UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 2321 UPDATE cdeA antibiotic efflux; multidrug and toxic compound extrusion (MATE) transporter; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; fluoroquinolone antibiotic; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 1822 UPDATE Staphylococcus aureus gyrB conferring resistance to aminocoumarin clorobiocin; aminocoumarin antibiotic; novobiocin; coumermycin A1; antibiotic target alteration; aminocoumarin resistant gyrB; ARO_description "UPDATED ARO_description with Point mutation in Staphylococcus aureus resulting in aminocoumarin resistance. " 445 UPDATE TEM-22 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y17583.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4925 UPDATE OXA-599 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1997 UPDATE tlrC mycinamicin; pleuromutilin antibiotic; macrolide antibiotic; lincomycin; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; tylosin; lincosamide antibiotic; model_sequences "UPDATED accession with M57437.1 " 2326 UPDATE TLA-3 antibiotic inactivation; monobactam; fluoroquinolone antibiotic; cephalosporin; TLA beta-lactamase; ARO_description "UPDATED ARO_description with TLA-3 is a beta-lactamase found in a transferable plasmid of Serratia marcescens clinical isolate. It confers resistance to ceftazidime, cefotaxime and cefepime, but not to cefmetazole and meropenem. " 4057 UPDATE OXA-573 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_056182.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4056 UPDATE OXA-570 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_056179.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4055 UPDATE OXA-926 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_070748.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4054 UPDATE OXA-835 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_065880.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4053 UPDATE OXA-541 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_052519.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4052 UPDATE OXA-737 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_062269.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4051 UPDATE OXA-681 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_062301.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4050 UPDATE OXA-543 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_068179.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4605 UPDATE FOX-15 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 2324 UPDATE gadW penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; cloxacillin; fluoroquinolone antibiotic; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4059 UPDATE OXA-672 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_062221.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4058 UPDATE OXA-571 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_056180.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 630 UPDATE adeJ antibiotic efflux; imipenem; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; trimethoprim; rifamycin antibiotic; penem; macrolide antibiotic; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; ticarcillin; tetracycline antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; model_sequences "UPDATED accession with AY769962.1 " 5674 UPDATE VEB-11 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 4361 UPDATE ALI-2 carbapenem; antibiotic inactivation; ALI beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 3610 UPDATE GOB-9 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3611 UPDATE HERA-2 penam; HERA beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2299 UPDATE Staphylococcus aureus walK with mutation conferring resistance to daptomycin peptide antibiotic; antibiotic target alteration; daptomycin resistant walK; daptomycin; model_sequences; model_name "UPDATED accession with BX571856.1 UPDATED accession with CAG39047.1 UPDATED model_name with Staphylococcus aureus walK with mutation conferring resistance to daptomycin " 2298 UPDATE SPM-1 carbapenem; SPM beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Sao Paulo metallo-beta-lactamase (SPM-1) confers resistance to carbapenem in Pseudomonas aeruginosa. " 3614 UPDATE HERA-5 penam; HERA beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3615 UPDATE HERA-6 penam; HERA beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3616 UPDATE HERA-8 penam; HERA beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3618 UPDATE IMP-49 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with From Lahey's list of beta-lactamases, no additional information available. UPDATED accession with KP681694.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3619 UPDATE IMP-52 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with LC055762.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2291 UPDATE Chlamydia trachomatis intrinsic murA conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant murA transferase; model_sequences "UPDATED accession with AY152390.1 UPDATED accession with AAN28945.1 " 2290 UPDATE Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin fosfomycin; antibiotic target alteration; antibiotic-resistant murA transferase; model_sequences "UPDATED accession with HE608151.1 UPDATED accession with CCE36834.1 " 631 UPDATE TEM-21 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y17582.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5679 UPDATE VEB-17 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 4360 UPDATE ALI-1 carbapenem; antibiotic inactivation; ALI beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4708 UPDATE IMP-83 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 288 UPDATE CMY-60 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JF460794.1 " 632 UPDATE basR pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_description "UPDATED ARO_description with Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). " 4932 UPDATE OXA-606 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3507 UPDATE OXA-437 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5029 UPDATE OXA-717 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5028 UPDATE OXA-716 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5021 UPDATE OXA-709 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 865 UPDATE OXA-244 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-244 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with JX438000.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5023 UPDATE OXA-711 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5191 UPDATE OXA-894 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5025 UPDATE OXA-713 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5024 UPDATE OXA-712 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5027 UPDATE OXA-715 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5026 UPDATE OXA-714 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1861 UPDATE LEN-15 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences; ARO_category "UPDATED accession with AF452105.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1860 UPDATE OXA-165 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM488986.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1863 UPDATE VIM-3 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF300454.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1862 UPDATE OXA-109 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-109 is a beta-lactamase found in A. baumannii. UPDATED accession with EF650035.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1865 UPDATE ACC-5 penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; model_sequences; ARO_category "UPDATED accession with HE819401.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1864 UPDATE CMY-67 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ711185.1 " 1869 UPDATE OXY-2-6 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-2-6 is a beta-lactamase found in Klebsiella oxytoca. UPDATED partial with 0 UPDATED sequence with ATGATAAAAAGTTCGTGGCGTAAAATTGCAATGCTAGCCGCCGCCGTTCCGCTGCTGCTGGCGAGCAGCGCACTGTGGGCCAGTACCGATGCTATCCATCAGAAGCTGACAGATCTCGAGAAGCGTTCAGGCGGCAGGTTGGGCGTGGCGCTAATCAACACGGCAGATAATTCTCAAATCTTATATCGCGGCGACGAGCGTTTTGCCATGTGCAGCACCAGTAAAGTGATGGCCGCCGCCGCGGTATTAAAACAGAGCGAAAGCAATAAAGAGGTGGTAAATAAAAGGCTGGAGATTAACGCAGCCGATTTGGTGGTCTGGAGTCCGATTACCGAAAAACATCTCCAGAGCGGAATGACGCTGGCTGAGCTAAGCGCGGCGACGCTGCAATATAGCGACAATACGGCGATGAATCTGATCATCGGCTACCTTGGCGGGCCGGAAAAAGTCACCGCCTTCGCCCGCAGTATCGGCGATGCCACCTTTCGTCTCGATCGTACGGAGCCCACGCTGAATACCGCCATCCCGGGCGATGAGCGTGATACCAGCACGCCGCTGGCGATGGCTGAAAGCCTACGCAAGCTGACGCTTGGCGATGCGCTGGGCGAACAGCAACGCGCCCAGTTAGTCACCTGGCTGAAAGGCAATACCACCGGCGGGCAAAGCATTCGCGCGGGCCTGCCTGAAAGCTGGGTGGTCGGCGATAAAACCGGCGCCGGAGATTACGGCACCACCAATGATATTGCGGTTATCTGGCCGGAAGATCACGCTCCGCTGGTATTAGTCACCTACTTTACCCAGCCGCAGCAGGATGCGAAAAACCGCAAAGAGGTGTTAGCCGCAGCGGCAAAAATCGTGACCGAAGGGCTTTAA UPDATED fmax with 1056 UPDATED accession with AY077485.2 UPDATED fmin with 183 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella oxytoca UPDATED NCBI_taxonomy_id with 571 UPDATED NCBI_taxonomy_cvterm_id with 36788 UPDATED accession with AAL78278.2 UPDATED sequence with MIKSSWRKIAMLAAAVPLLLASSALWASTDAIHQKLTDLEKRSGGRLGVALINTADNSQILYRGDERFAMCSTSKVMAAAAVLKQSESNKEVVNKRLEINAADLVVWSPITEKHLQSGMTLAELSAATLQYSDNTAMNLIIGYLGGPEKVTAFARSIGDATFRLDRTEPTLNTAIPGDERDTSTPLAMAESLRKLTLGDALGEQQRAQLVTWLKGNTTGGQSIRAGLPESWVVGDKTGAGDYGTTNDIAVIWPEDHAPLVLVTYFTQPQQDAKNRKEVLAAAAKIVTEGL UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1868 UPDATE TEM-82 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF427128.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4686 UPDATE IMP-59 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4687 UPDATE IMP-60 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4684 UPDATE IMP-54 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4685 UPDATE IMP-58 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4934 UPDATE OXA-608 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4683 UPDATE IMP-53 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4680 UPDATE IMP-23 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4681 UPDATE IMP-39 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4938 UPDATE OXA-612 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5190 UPDATE OXA-893 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 401 UPDATE ACT-22 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KF992027.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 968 UPDATE MIR-15 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087851.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 969 UPDATE VEB-8 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX679208.1 UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 4688 UPDATE IMP-61 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4689 UPDATE IMP-62 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2109 UPDATE Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutation in Mycobacterium tuberculosis gyrB resulting in fluoroquinolone resistance. UPDATED model_name with Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones " 2108 UPDATE Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A antibiotic target alteration; elfamycin antibiotic; GE2270A; elfamycin resistant EF-Tu; ARO_description "UPDATED ARO_description with Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to GE2270A. " 1710 UPDATE Mycobacterium leprae gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutation in Mycobacterium leprae gyrB resulting in fluoroquinolone resistance. UPDATED accession with AL450380.1 UPDATED model_name with Mycobacterium leprae gyrB conferring resistance to fluoroquinolones " 32 UPDATE DHA-15 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087853.1 " 2103 UPDATE SHV-3 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2102 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B antibiotic target alteration; hygromycin B; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; model_name "UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B " 2106 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A kanamycin A; antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_name "UPDATED ARO_description with Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A " 2105 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to neomycin antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; ARO_description "UPDATED ARO_description with Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to neomycin. " 2104 UPDATE Ureaplasma urealyticum parC conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; sparfloxacin; levofloxacin; fluoroquinolone resistant parC; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description; model_name "UPDATED ARO_description with Point mutation in Ureaplasma urealyticum parC resulting in fluoroquinolone resistance. UPDATED model_name with Ureaplasma urealyticum parC conferring resistance to fluoroquinolones " 5115 UPDATE OXA-810 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5114 UPDATE OXA-809 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5117 UPDATE OXA-813 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5116 UPDATE OXA-811 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5111 UPDATE OXA-806 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5110 UPDATE OXA-805 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5113 UPDATE OXA-808 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5112 UPDATE OXA-807 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 37 UPDATE Escherichia coli mdfA antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; benzalkonium chloride; tetracycline antibiotic; disinfecting agents and antiseptics; tetracycline; model_sequences; ARO_category "UPDATED accession with JQ394987.1 UPDATED category_aro_class_name with Antibiotic DELETED 40518 UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 662 UPDATE TEM-162 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF468463.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5119 UPDATE OXA-815 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5118 UPDATE OXA-814 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4870 UPDATE OXA-536 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1717 UPDATE OXA-230 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-230 is a beta-lactamase found in A. bereziniae. UPDATED accession with JQ422054.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 35 UPDATE FosA2 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; model_sequences "UPDATED accession with EU487198.1 " 565 UPDATE SHV-82 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACACCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM176557.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47137.2 UPDATED sequence with MRYVRLCIISLLATLPLAVHTSPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 34 UPDATE OXY-6-3 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-6-3 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ871876.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4933 UPDATE OXA-607 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3438 UPDATE OXA-271 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1537 UPDATE GES-2 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-2 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AF326355.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4936 UPDATE OXA-610 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 878 UPDATE CTX-M-142 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KF240809.1 " 879 UPDATE TEM-185 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with TEM-185 is a beta-lactamase found in E. coli. UPDATED accession with JF795538.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3430 UPDATE OXA-263 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3431 UPDATE OXA-264 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Acinetobacter haemolyticus CIP 64.3 = MTCC 9819 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3432 UPDATE OXA-265 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3433 UPDATE OXA-266 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3434 UPDATE OXA-267 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 873 UPDATE KPC-19 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ775801.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3436 UPDATE OXA-269 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3437 UPDATE OXA-270 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2743 UPDATE Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description; model_description; ARO_id; ARO_category; ARO_accession "UPDATED ARO_description with AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli. UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED ARO_id with 40492 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic DELETED 35977 UPDATED category_aro_name with antibiotic target alteration UPDATED category_aro_cvterm_id with 35997 UPDATED category_aro_accession with 0001001 UPDATED category_aro_class_name with Resistance Mechanism UPDATED category_aro_description with Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED category_aro_name with protein(s) and two-component regulatory system modulating antibiotic efflux UPDATED category_aro_cvterm_id with 36590 UPDATED category_aro_accession with 3000451 UPDATED category_aro_class_name with Efflux Regulator UPDATED category_aro_description with Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux. UPDATED ARO_accession with 3003807 " 4848 UPDATE OXA-513 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2744 UPDATE Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description; model_description; ARO_id; ARO_category; ARO_accession "UPDATED ARO_description with MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED ARO_id with 39962 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic DELETED 35954 UPDATED category_aro_name with antibiotic target alteration UPDATED category_aro_cvterm_id with 35997 UPDATED category_aro_accession with 0001001 UPDATED category_aro_class_name with Resistance Mechanism UPDATED category_aro_description with Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED category_aro_name with protein(s) and two-component regulatory system modulating antibiotic efflux UPDATED category_aro_cvterm_id with 36590 UPDATED category_aro_accession with 3000451 UPDATED category_aro_class_name with Efflux Regulator UPDATED category_aro_description with Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux. UPDATED ARO_accession with 3003378 " 2747 UPDATE AcrEF-TolC confers resistance to ciprofloxacin penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; ciprofloxacin; fluoroquinolone antibiotic; model_description; ARO_category; model_name "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with AcrEF-TolC confers resistance to ciprofloxacin " 2746 UPDATE AcrAD-TolC confers resistance to amikacin, gentamicin, and tobramycin efflux pump complex or subunit conferring antibiotic resistance; aminoglycoside antibiotic; resistance-nodulation-cell division (RND) antibiotic efflux pump; antibiotic efflux; ARO_accession; ARO_description; ARO_category; ARO_name; model_description; ARO_id; model_name "UPDATED ARO_accession with 3004082 UPDATED ARO_description with AcrAD-TolC efflux pump system in E. coli from the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. DELETED 35933 UPDATED ARO_name with AcrAD-TolC UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED ARO_id with 41184 UPDATED model_name with AcrAD-TolC " 9 UPDATE ACT-35 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with LC004922.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4845 UPDATE OXA-510 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4846 UPDATE OXA-511 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4847 UPDATE OXA-512 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4840 UPDATE OXA-505 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4841 UPDATE OXA-506 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4842 UPDATE OXA-507 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4843 UPDATE OXA-508 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 890 UPDATE SHV-53 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 1 UPDATED sequence with ATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGATCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAA UPDATED fmax with 729 UPDATED accession with AY590467.1 UPDATED fmin with 1 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAT01223.1 UPDATED sequence with IISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLISQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNN UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 891 UPDATE QnrB37 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB37 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JN173059.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 892 UPDATE APH(6)-Ic antibiotic inactivation; APH(6); streptomycin; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(6)-Ic is a transposon-encoded aminoglycoside phosphotransferase in S. enterica, P. aeruginosa and E. coli. UPDATED accession with X01702.1 UPDATED category_aro_description with Phosphorylation of streptomycin on the hydroxyl group at position 6. " 4937 UPDATE OXA-611 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 894 UPDATE CMY-90 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with HE819404.1 " 895 UPDATE SHV-122 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 897 UPDATE OXA-383 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 898 UPDATE VEB-9 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 899 UPDATE OXA-94 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-94 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ519088.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 646 UPDATE OXA-349 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF297578.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5104 UPDATE OXA-799 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5201 UPDATE OXA-909 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5200 UPDATE OXA-908 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5203 UPDATE OXA-911 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5202 UPDATE OXA-910 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5205 UPDATE OXA-913 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5204 UPDATE OXA-912 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5207 UPDATE OXA-916 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5206 UPDATE OXA-914 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5209 UPDATE OXA-918 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5208 UPDATE OXA-917 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5198 UPDATE OXA-905 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3544 UPDATE OXA-483 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3545 UPDATE OXA-484 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3546 UPDATE OXA-485 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3547 UPDATE OXA-486 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3540 UPDATE OXA-478 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3541 UPDATE OXA-479 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3542 UPDATE OXA-480 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3548 UPDATE OXA-488 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3549 UPDATE ARL-1 penam; antibiotic inactivation; ARL Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3955 UPDATE SHV-227 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1911 UPDATE AAC(6')-Iad AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iad is a plasmid-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 3. UPDATED accession with AB119105.1 " 5195 UPDATE OXA-902 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5194 UPDATE OXA-901 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1964 UPDATE IMP-45 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-45 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with KJ510410.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4939 UPDATE OXA-613 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1788 UPDATE ACT-6 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACT-6 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with FJ237366.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1789 UPDATE QnrB44 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; ARO_category "UPDATED ARO_description with QnrB44 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 768 UPDATE SHV-43 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY065991.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5196 UPDATE OXA-903 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1780 UPDATE OXA-146 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-146 is a beta-lactamase found in Enterobacteriaceae. UPDATED accession with FJ194494.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1781 UPDATE AAC(2')-Ia antibiotic inactivation; AAC(2'); arbekacin; gentamicin B; gentamicin C; amikacin; aminoglycoside antibiotic; tobramycin; ARO_description; model_sequences "UPDATED ARO_description with AAC(2')-Ia is a chromosomal-encoded aminoglycoside acetyltransferase in P. stuartii. UPDATED partial with 0 UPDATED sequence with ATGGGCATAGAATACCGCAGTCTGCATACCAGCCAATTGACACTGAGTGAAAAAGAAGCGCTTTACGATTTATTAATTGAAGGTTTTGAAGGCGATTTTTCGCATGACGATTTCGCGCACACTTTAGGTGGAATGCACGTCATGGCTTTTGATCAACAAAAATTGGTTGGTCATGTTGCAATTATTCAACGCCATATGGCCCTAGATAATACGCCTATCTCTGTAGGGTATGTTGAAGCGATGGTAGTTGAACAAAGTTATCGTCGCCAAGGTATTGGGCGGCAATTGATGCTGCAAACCAATAAAATTATAGCTTCGTGTTATCAATTAGGGCTGCTGTCGGCTTCAGATGATGGACAAAAATTGTATCATTCGGTTGGATGGCAAATCTGGAAAGGTAAGTTGTTTGAATTGAAACAAGGGAGCTATATCCGTTCTATTGAAGAAGAAGGCGGAGTCATGGGCTGGAAAGCGGATGGTGAGGTTGATTTTACCGCTTCGCTTTACTGTGATTTTCGTGGCGGTGATCAGTGGTAA UPDATED fmax with 800 UPDATED accession with L06156.2 UPDATED fmin with 263 UPDATED strand with + UPDATED NCBI_taxonomy_name with Providencia stuartii UPDATED NCBI_taxonomy_id with 588 UPDATED NCBI_taxonomy_cvterm_id with 36946 UPDATED accession with AAA03550.1 UPDATED sequence with MGIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHVMAFDQQKLVGHVAIIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLMLQTNKIIASCYQLGLLSASDDGQKLYHSVGWQIWKGKLFELKQGSYIRSIEEEGGVMGWKADGEVDFTASLYCDFRGGDQW " 1782 UPDATE TEM-12 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with M88143.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1783 UPDATE VIM-36 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-36 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with JX982635.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1784 UPDATE OXA-334 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203108.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1785 UPDATE TEM-48 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y10280.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1786 UPDATE mexY erythromycin; arbekacin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; model_sequences; ARO_category "UPDATED accession with AB015853.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 1787 UPDATE VIM-42 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP071470.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5193 UPDATE OXA-900 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2256 UPDATE Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid antibiotic resistant fusE; antibiotic target alteration; fusidic acid; model_name "UPDATED model_name with Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid " 1963 UPDATE TEM-190 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN416112.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5148 UPDATE OXA-851 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 338 UPDATE OXY-1-2 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-1-2 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ871865.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 325 UPDATE LEN-23 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-23 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCGGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTAGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGCTCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 861 UPDATED accession with AM850913.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12351.2 UPDATED sequence with MRYVRLCVISLLATLPLAVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVLYLRDTPASMAERNQHIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1078 UPDATE VIM-4 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-4 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AM087411.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1079 UPDATE OXA-161 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-161 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with GQ202693.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1913 UPDATE dfrK trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrK is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. UPDATED accession with FN812951.1 " 461 UPDATE OXA-13 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with U59183.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1678 UPDATE AAC(6')-Ib-cr1 antibiotic inactivation; AAC(6')-Ib-cr; plazomicin; ciprofloxacin; fluoroquinolone antibiotic; aminoglycoside antibiotic; tobramycin; ARO_description; model_name "UPDATED ARO_description with AAC(6')-Ib-cr is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Enterobacteriaceae. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. UPDATED model_name with AAC(6')-Ib-cr1 " 1679 UPDATE OXA-49 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-49 is a beta-lactamase found in A. baumannii. UPDATED accession with AY288523.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1674 UPDATE AAC(6')-It AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-It is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 16. UPDATED accession with AF031328.1 " 1675 UPDATE CTX-M-5 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-5 is a beta-lactamase found in Salmonella typhimurium. UPDATED accession with U95364.1 " 1676 UPDATE GES-18 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-18 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with JQ028729.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1677 UPDATE cepA CepA beta-lactamase; antibiotic inactivation; cephalosporin; ARO_description; model_sequences; model_name; ARO_category "UPDATED ARO_description with A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity. UPDATED accession with U05883.1 UPDATED model_name with cepA UPDATED category_aro_name with CepA beta-lactamase UPDATED category_aro_description with CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin. " 1670 UPDATE nalC sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1671 UPDATE Salmonella serovars soxS with mutation conferring antibiotic resistance penem; antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; reduced permeability to antibiotic; carbapenem; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; tigecycline; glycylcycline; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1672 UPDATE TEM-211 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF513179.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1673 UPDATE QnrA6 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrA6 is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. UPDATED accession with DQ151889.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1094 UPDATE CARB-17 penam; antibiotic inactivation; CARB beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ934265.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1095 UPDATE SHV-59 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY790341.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1096 UPDATE TEM-79 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF190692.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1097 UPDATE Erm(38) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 678 UPDATE PDC-10 antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; PDC beta-lactamase; monobactam; model_sequences "UPDATED accession with FJ666073.1 " 679 UPDATE SHV-108 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM751100.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4339 UPDATE ADC-83 antibiotic inactivation; cephalosporin; ADC beta-lactamases pending classification for carbapenemase activity; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1098 UPDATE vanB glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; model_sequences; ARO_category "UPDATED accession with KF823969.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 1099 UPDATE OXA-48 antibiotic inactivation; penam; carbapenem; cephalosporin; temocillin; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-48 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTGTATTAGCCTTATCGGCTGTGTTTTTGGTGGCATCGATTATCGGAATGCCTGCGGTAGCAAAGGAATGGCAAGAAAACAAAAGTTGGAATGCTCACTTTACTGAACATAAATCACAGGGCGTAGTTGTGCTCTGGAATGAGAATAAGCAGCAAGGATTTACCAATAATCTTAAACGGGCGAACCAAGCATTTTTACCCGCATCTACCTTTAAAATTCCCAATAGCTTGATCGCCCTCGATTTGGGCGTGGTTAAGGATGAACACCAAGTCTTTAAGTGGGATGGACAGACGCGCGATATCGCCACTTGGAATCGCGATCATAATCTAATCACCGCGATGAAATATTCAGTTGTGCCTGTTTATCAAGAATTTGCCCGCCAAATTGGCGAGGCACGTATGAGCAAGATGCTACATGCTTTCGATTATGGTAATGAGGACATTTCGGGCAATGTAGACAGTTTCTGGCTCGACGGTGGTATTCGAATTTCGGCCACGGAGCAAATCAGCTTTTTAAGAAAGCTGTATCACAATAAGTTACACGTATCGGAGCGCAGCCAGCGTATTGTCAAACAAGCCATGCTGACCGAAGCCAATGGTGACTATATTATTCGGGCTAAAACTGGATACTCGACTAGAATCGAACCTAAGATTGGCTGGTGGGTCGGTTGGGTTGAACTTGATGATAATGTGTGGTTTTTTGCGATGAATATGGATATGCCCACATCGGATGGTTTAGGGCTGCGCCAAGCCATCACAAAAGAAGTGCTCAAACAGGAAAAAATTATTCCCTAG UPDATED fmax with 2985 UPDATED accession with AY236073.2 UPDATED fmin with 2187 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAP70012.1 UPDATED sequence with MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5182 UPDATE OXA-885 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3137 UPDATE MCR-3.8 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with An MCR-3 polymyxin (incl. colistin) resistance gene variant identified from an Aeromonas isolate. " 3130 UPDATE MCR-2.2 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in Great Britain. " 3139 UPDATE MCR-3.2 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with An MCR-3 polymyxin resistance gene variant identified in a colistin-resistant Salmonella isolate from Canada, located on an IncHI-2 plasmid. " 3138 UPDATE MCR-3.7 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with An MCR polymyxin (colistin) resistance gene variant identified in Aeromonas. " 4945 UPDATE OXA-619 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1533 UPDATE SHV-143 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4100 UPDATE KPC-35 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-35 [Klebsiella pneumoniae] Accession: WP_111273852.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1915 UPDATE CMY-47 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGAGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGTTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA UPDATED fmax with 2185 UPDATED accession with HM046998.2 UPDATED fmin with 1039 UPDATED strand with + UPDATED NCBI_taxonomy_name with Citrobacter freundii UPDATED NCBI_taxonomy_id with 546 UPDATED NCBI_taxonomy_cvterm_id with 36915 UPDATED accession with ADH82410.1 UPDATED sequence with MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ " 4443 UPDATE CepA-44 CepA beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_name with CepA beta-lactamase UPDATED category_aro_description with CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin. " 4103 UPDATE KPC-38 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-38 [Klebsiella pneumoniae] Accession: WP_123002101.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4982 UPDATE OXA-662 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5183 UPDATE OXA-886 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1418 UPDATE DHA-6 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with DHA-6 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with HQ322612.1 " 1419 UPDATE OXA-454 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED accession with LC037981.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5192 UPDATE OXA-896 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1410 UPDATE OXA-19 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF043381.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1411 UPDATE OXA-62 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-62 is a beta-lactamase found in Pandoraea pnomenusa. UPDATED accession with AY423074.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1412 UPDATE SHV-167 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB733453.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1413 UPDATE OXA-172 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-172 is a beta-lactamase found in A. baumannii. UPDATED accession with HM113558.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1414 UPDATE QnrB15 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB15 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with EU302865.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1415 UPDATE AAC(2')-Id antibiotic inactivation; AAC(2'); arbekacin; gentamicin B; gentamicin C; amikacin; aminoglycoside antibiotic; tobramycin; ARO_description; model_sequences "UPDATED ARO_description with AAC(2')-Id is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium smegmatis. UPDATED accession with U72743.1 " 1416 UPDATE OXA-89 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-89 is a beta-lactamase found in A. baumannii. UPDATED accession with DQ445683.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1417 UPDATE OXA-131 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-131 is a beta-lactamase found in A. baumannii. UPDATED accession with EU547446.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1322 UPDATE SHV-65 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ174305.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1323 UPDATE Salmonella serovars parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description "UPDATED ARO_description with Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance. " 1320 UPDATE Klebsiella mutant PhoP conferring antibiotic resistance to colistin antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; pmr phosphoethanolamine transferase; colistin A; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; erythromycin; ARO_description "UPDATED ARO_description with A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge. " 1321 UPDATE mecA penam; methicillin resistant PBP2; methicillin; antibiotic target replacement; model_sequences; ARO_category "UPDATED accession with KC243783.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1326 UPDATE OXA-170 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HM488991.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1327 UPDATE AAC(6')-Iq AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iq is a aminoglycoside acetyltransferase encoded by plasmids and integrons in K. pneumoniae. UPDATED accession with AF047556.1 " 1324 UPDATE LRA-2 penam; antibiotic inactivation; subclass B3 LRA beta-lactamase; cephalosporin; ARO_description; ARO_category "UPDATED ARO_description with LRA-2 is a beta-lactamase isolated from soil samples in Alaska. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1325 UPDATE OXA-65 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-65 is a beta-lactamase found in A. baumannii. UPDATED accession with AY750908.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1328 UPDATE vanSM glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSM, is a vanS variant found in the vanM gene cluster. UPDATED accession with FJ349556.1 UPDATED model_name with vanS gene in vanM cluster UPDATED ARO_name with vanS gene in vanM cluster " 1329 UPDATE ANT(4')-IIb antibiotic inactivation; aminoglycoside antibiotic; ribostamycin; paromomycin; kanamycin A; gentamicin B; lividomycin B; ANT(4'); lividomycin A; isepamicin; G418; neomycin; tobramycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ANT(4')-IIb is a transposon-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa. UPDATED accession with AY114142.1 UPDATED category_aro_description with Nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 4'. " 5180 UPDATE OXA-883 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1053 UPDATE SHV-2 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF148851.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4647 UPDATE GOB-34 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 647 UPDATE TEM-89 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY039040.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1256 UPDATE bmr antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; puromycin; acriflavine; nucleoside antibiotic; fluoroquinolone antibiotic; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with bmr is an MFS antibiotic efflux pump that confers resistance to multiple drugs including acridine dyes, fluoroquinolone antibiotics, chloramphenicol, and puromycin. UPDATED accession with M33768.1 UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 1525 UPDATE TEM-160 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF136377.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1254 UPDATE CTX-M-46 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-46 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY847147.1 " 1527 UPDATE SHV-51 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY289548.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1520 UPDATE SHV-85 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ322460.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1521 UPDATE VIM-32 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGTTAAAAGTTATTAGTAGTTTATTGGTCTACATGACCGCGTCTGTCATGGCTGTCGCAAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGACTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCGGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAAAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAGCGGGGAACGAGATTCCCACGCATTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCTGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAACGTGCTATACGGTGGTTGTGCCGTTCATGAGTTGTCAAGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCAAAGCACACAAAAATCGCTCAGTCGCCGAGTAG UPDATED fmax with 2350 UPDATED accession with JN676230.2 UPDATED fmin with 1549 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella oxytoca UPDATED NCBI_taxonomy_id with 571 UPDATED NCBI_taxonomy_cvterm_id with 36788 UPDATED accession with AEZ49857.1 UPDATED sequence with MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAAGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1522 UPDATE IMP-38 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with HQ875573.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1523 UPDATE MexD penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; trimethoprim; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; gentamicin C; chloramphenicol; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; model_sequences; ARO_category "UPDATED accession with U57969.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1528 UPDATE TEM-168 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with FJ919776.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1529 UPDATE TEM-130 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ866988.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1258 UPDATE OXA-55 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY343493.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1259 UPDATE SHV-31 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCAAACGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 927 UPDATED accession with AY277255.2 UPDATED fmin with 66 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAP33454.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 308 UPDATE CMY-118 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM087838.1 " 309 UPDATE CMY-35 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with EF394371.1 " 3959 UPDATE SHV-1b-b carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 08-JUN-2016. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3958 UPDATE SHV-207 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella penumoniae. Directly submitted to NCBI without publications on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3953 UPDATE SHV-219 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3952 UPDATE SHV-211 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 7-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3951 UPDATE SHV-196 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 19-SEP-2016. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 303 UPDATE ErmQ antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with L22689.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 3957 UPDATE SHV-214 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3956 UPDATE SHV-223 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumonia. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 306 UPDATE SHV-32 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY037778.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3954 UPDATE SHV-199 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Escherichia coli. Directly submitted to NCBI without publication on 10-AUG-2017. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4116 UPDATE KPC-55 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-55 [Klebsiella pneumoniae] Accession: WP_168247883.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4117 UPDATE KPC-56 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-56 [Klebsiella pneumoniae] Accession: WP_087744800.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4114 UPDATE KPC-52 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-52 [Klebsiella pneumoniae] Accession: WP_158208806.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4115 UPDATE KPC-54 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-54 [Klebsiella pneumoniae] Accession: WP_160164839.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4112 UPDATE KPC-50 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant class A beta-lactamase kpc-50 [Klebsiella pneumoniae] Accession: WP_171476788.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4113 UPDATE KPC-51 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-51 [Klebsiella pneumoniae] Accession: WP_158208923.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4110 UPDATE KPC-46 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-46 [Klebsiella pneumoniae] Accession: WP_148044421.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4111 UPDATE KPC-49 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-49 [Escherichia coli] Accession: WP_197749402.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 649 UPDATE OXA-115 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU029998.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4118 UPDATE KPC-57 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-57 [Klebsiella pneumoniae] Accession: WP_171476789.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1546 UPDATE Erm(43) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with Erm(43) is a macrolide, lincosamide, and streptogramin B resistance gene found in Mammaliicoccus lentus chromosome isolated from human, dog and chicken. UPDATED accession with HE650138.1 UPDATED NCBI_taxonomy_name with Mammaliicoccus lentus " 2858 UPDATE PDC-79 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 5187 UPDATE OXA-890 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 958 UPDATE OXA-418 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KJ997966.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2399 UPDATE oqxA antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; trimethoprim; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; tigecycline; glycylcycline; ciprofloxacin; tetracycline antibiotic; nitrofuran antibiotic; fluoroquinolone antibiotic; nitrofurantoin; ARO_description "UPDATED ARO_description with RND efflux pump conferring resistance to fluoroquinolone. " 5010 UPDATE OXA-698 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 852 UPDATE QnrB62 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB62 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JX987101.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 5184 UPDATE OXA-887 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5011 UPDATE OXA-699 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1209 UPDATE QnrB45 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; ARO_category "UPDATED ARO_description with QnrB45 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 5012 UPDATE OXA-700 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5013 UPDATE OXA-701 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4062 UPDATE OXA-931 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_070786.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4063 UPDATE OXA-930 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_070785.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4060 UPDATE OXA-671 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGATCATGTCGAAAAAATTAAAATGTCTGACGCTTTTTACAGCCATCTTTTTTGCAATTCCTATGGCTGCTTGTCAAAGTTTAAGCCAACAAAAGCAACAGCTCACGACAGAAAAAAATGATCAGCAGCAGATCTCAAGTTTATTCCAGAGCGCTCAAACCAGTGGTGTTTTGGTGATTTATGACGGCAAGAAAATTCAAAGCTATGGCAATGCGCTTGATCGTGCAGAGCAGCGTTATATTCCCGCCTCAACCTTTAAAATGTTGAATGCTTTGATCGGGATACAACATCATAAGACTGCACCAAATGAAGTGTTTAAATGGGATGGAAAAAAGCGAGCATTTAGTAGCTGGGAAAAAGATTTAACCTTAGCTGAAGCGATGCAGGCATCGGCGGTACCCGTTTATCAAGAGTTGGCAAGACGGATTGGTTTAGAACTGATGACCCGTGAAGTGAAGCGTGTAGGTTATGGTAATAAAAATATTGGGACGCAAGTGGATAATTTCTGGTTAGTTGGTCCCTTAAAAATCACTCCCGTAGAGGAAGTTCGCTTTGCCTATGCATTAGCAAAACAGAAATTACCCTTTGATCAGCCGACACAGCAACAAGTCAAAGCGATGTTATTGGTGGATCAGATCCAGGATACCAAAATCTATGCCAAAAGCGGTTGGGGAATGGATGTCAGCCCGCAAGTGGGTTGGTGGACGGGGTGGATTGAACAGCCAAATGGTAAGGTCATTGCATTCTCATTGAATATGCAAATGAGCCAGCCTGAACATGCAGATGCACGTAAAGCGATTGTGTATCAAGCCTTGCAACAGTTGGGATTGTTAGCCACTTAA UPDATED fmax with 943 UPDATED accession with NG_062218.2 UPDATED fmin with 100 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter gyllenbergii UPDATED NCBI_taxonomy_id with 134534 UPDATED NCBI_taxonomy_cvterm_id with 42559 UPDATED accession with WP_081401608.1 UPDATED sequence with MIMSKKLKCLTLFTAIFFAIPMAACQSLSQQKQQLTTEKNDQQQISSLFQSAQTSGVLVIYDGKKIQSYGNALDRAEQRYIPASTFKMLNALIGIQHHKTAPNEVFKWDGKKRAFSSWEKDLTLAEAMQASAVPVYQELARRIGLELMTREVKRVGYGNKNIGTQVDNFWLVGPLKITPVEEVRFAYALAKQKLPFDQPTQQQVKAMLLVDQIQDTKIYAKSGWGMDVSPQVGWWTGWIEQPNGKVIAFSLNMQMSQPEHADARKAIVYQALQQLGLLAT UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4061 UPDATE OXA-673 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_062214.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4066 UPDATE Trimethoprim-resistant dihydrofolate reductase DfrA42 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGCACAAACCAACCCCATTAAAACGGTTGTCGATGATACTTGCTCGTGACCTTAATGGTGCCATTGGTTACGAAGGTTCTTTGGCCATTAAATCGGACAATGATTTTGCGTGGTATAAGAAAATTACCAAACCATTTAAGCACGCTGTTTGTGGGCGAGTAACCTATGAGGAAGATTTGCCCGATATCGTCAAAAAACGCCACAGATTCATCATTATTACCCGTAATCCAGACAAGTACGCTAGTACTCCTGAAGCACAGTATATGACGCTCTCAGACGCGTTAAAAGAGTTACAAGTTTGGGACGTACCTGGTCACGACATTATCTGCTTAGGTGGTGCTGAAATTTACAAGGCATTATTGCCTTACGTTAGTACTGTTTACCTGACTACATTCTTTTCAGTAGCAGATGAAGCAGATACTTATTTCAATGACTTTACAGATAAATGGGAATCAGTAGGGGCCACTTGGTTTAACGACTGCTACTGCACCCGTCTGGAGCGTGTATGTCAATCTACAAACAATATTATCTAA UPDATED fmax with 8262 UPDATED accession with HQ386845.2 UPDATED fmin with 7728 UPDATED strand with + UPDATED NCBI_taxonomy_name with Gammaproteobacteria UPDATED NCBI_taxonomy_id with 1236 UPDATED NCBI_taxonomy_cvterm_id with 40536 UPDATED accession with WP_045475347.1 UPDATED sequence with MHKPTPLKRLSMILARDLNGAIGYEGSLAIKSDNDFAWYKKITKPFKHAVCGRVTYEEDLPDIVKKRHRFIIITRNPDKYASTPEAQYMTLSDALKELQVWDVPGHDIICLGGAEIYKALLPYVSTVYLTTFFSVADEADTYFNDFTDKWESVGATWFNDCYCTRLERVCQSTNNII " 4067 UPDATE OXA-496 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_050781.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4064 UPDATE OXA-895 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_067157.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4065 UPDATE OXA-641 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_057486.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4068 UPDATE OXA-915 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_068224.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4069 UPDATE oxa-647 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_name; model_sequences; model_name; ARO_category "UPDATED ARO_name with OXA-647 UPDATED accession with NG_065433.1 UPDATED model_name with OXA-647 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 732 UPDATE OXA-237 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-237 is a beta-lactamase found in A. baumannii. UPDATED accession with JQ820241.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 657 UPDATE SHV-142 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ029959.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4893 UPDATE OXA-564 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4442 UPDATE CepA-29 CepA beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_name with CepA beta-lactamase UPDATED category_aro_description with CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin. " 5019 UPDATE OXA-707 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4788 UPDATE OKP-B-34 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 980 UPDATE y56 beta-lactamase penam; antibiotic inactivation; BlaA beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Class A beta-lactamase found in Yersinia enterocolitica biovar 1A. UPDATED accession with AY954728.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3603 UPDATE GOB-2 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3602 UPDATE GOB-16 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3601 UPDATE GOB-15 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3600 UPDATE GOB-14 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3607 UPDATE GOB-6 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3606 UPDATE GOB-5 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3605 UPDATE GOB-4 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4897 UPDATE OXA-568 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3609 UPDATE GOB-8 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3608 UPDATE GOB-7 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4896 UPDATE OXA-567 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5038 UPDATE OXA-728 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 982 UPDATE TEM-153 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC149518.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 984 UPDATE Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; fluoroquinolone resistant gyrA; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; model_sequences "UPDATED accession with AF469609.1 " 3893 UPDATE CMY-158 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_062242.1 " 640 UPDATE tet(31) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AJ250203.1 " 623 UPDATE OXA-68 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-68 is a beta-lactamase found in A. baumannii. UPDATED accession with AY750910.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1489 UPDATE CMY-37 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-37 is a beta-lactamase found in Citrobacter freundii. UPDATED accession with AB280919.1 " 114 UPDATE dfrA13 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA13 is an integron-encoded dihydrofolate reductase found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGAACCCGGAATCGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGTCCCGATATCCCCTGGAAAATCCCAGGTGAGCAGAAGATTTTTCGCAGGCTCACCGAGAGCAAAGTGGTCGTTATGGGCCGCAAGACATTTGAGTCCATAGGCAAGCCCTTACCAAACCGCCACACAGTGGTGCTCTCGCGCCAAGCTGGTTATAGCGCTCCTGGTTGTGCAGTTGTTTCAACGCTGTCACACGTATCGCCATCGACAGCCGAACACGGCAAAGAACTCTACGTAGCGCGCGGAGCCGAGGTATATGCGCTGGCGCTACCGCATGCCAACGGCGTCTTTCTATCTGAGGTACATCAAACCTTTGAGGGTGACGCCTTCTTCCCAGTGCTTAACGCAGCAGAATTCGAGGTTGTCTCATCCGAAACCATTCAAGGCACAATCACGTACACGCACTCCGTCTATGCGCGTCGTAACGGCTAA UPDATED fmax with 1215 UPDATED accession with Z50802.3 UPDATED fmin with 717 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with CAA90683.1 UPDATED sequence with MNPESVRIYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVVLSRQAGYSAPGCAVVSTLSHVSPSTAEHGKELYVARGAEVYALALPHANGVFLSEVHQTFEGDAFFPVLNAAEFEVVSSETIQGTITYTHSVYARRNG " 5039 UPDATE OXA-729 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 622 UPDATE DHA-7 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with DHA-7 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with HQ456945.1 " 1049 UPDATE MOX-1 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with MOX-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGAGCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA UPDATED fmax with 1381 UPDATED accession with D13304.2 UPDATED fmin with 232 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with BAA02563.2 UPDATED sequence with MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4624 UPDATE GES-41 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4620 UPDATE GES-37 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1899 UPDATE vanYF glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanY; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanYF, is a vanY variant found in the vanF gene cluster. UPDATED accession with AF155139.1 UPDATED model_name with vanY gene in vanF cluster UPDATED ARO_name with vanY gene in vanF cluster " 1894 UPDATE Salmonella enterica ramR mutants penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1895 UPDATE CfxA3 antibiotic inactivation; cephamycin; CfxA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CfxA3 beta-lactamase is a class A beta-lactamase found in Capnocytophaga ochracea. UPDATED partial with 0 UPDATED sequence with ATGGAAAAAAACAGAAAAAAACAAATCGTAGTTTTGAGTATAGCTTTAGTTTGCATTTTCATCTTGGTATTTTCATTGTTCCATAAATCAGCGACAAAAGATAGCGCAAATCCTCCTTTAACAAATGTTTTGACTGATAGCATTTCTCAAATTGTCTCAGCTTGTCCTGGCGAAATTGGTGTGGCGGTTATTGTTAATAACAGAGATACGGTTAAGGTCAATAATAAGAGTGTTTATCCTATGATGAGTGTGTTTAAGGTTCATCAGGCATTAGCTCTTTGTAATGACTTTGACAATAAAGGAATTTCACTTGATACCTTAGTAAATATAAATAGGGATAAACTTGACCCAAAGACTTGGAGTCCTATGCTGAAAGATTATTCAGGGCCAGTCATATCATTGACAGTGAGAGATTTGCTGCGTTATACTCTTACTCAGAGTGACAACAATGCAAGCAACCTTATGTTTAAGGATATGGTTAATGTCGCTCAAACAGATAGTTTTATAGCCACACTCATTCCTCGTTCAAGTTTTCAGATAGCTTATACGGAAGAGGAAATGTCGGCTGACCATAACAAGGCTTACTCTAACTATACATCTCCTCTTGGTGCTGCAATGTTGATGAATCGTTTGTTTACTGAAGGTCTTATCGATGATGAGAAACAAAGTTTCATTAAGAATACGTTAAAAGAATGCAAAACAGGTGTAGATAGGATAGCAGCTCCACTTCTTGATAAAGAAGGGGTTGTTATAGCGCATAAGACAGGTTCAGGTGATGTTAATGAAAATGGTGTTCTTGCAGCTCACAATGATGTTGCCTATATATGTCTGCCTAATAATATCAGTTATACCTTAGCGGTATTTGTTAAGGATTTCAAGGGAAATGAATCACAAGCGTCACAATATGTTGCGCATATATCAGCTGTAGTATATTCTTTATTAATGCAAACTTCAGTAAAATCTTAA UPDATED fmax with 1018 UPDATED accession with AF472622.2 UPDATED fmin with 52 UPDATED strand with + UPDATED NCBI_taxonomy_name with Capnocytophaga ochracea UPDATED NCBI_taxonomy_id with 1018 UPDATED NCBI_taxonomy_cvterm_id with 36958 UPDATED accession with AAL79549.2 UPDATED sequence with MEKNRKKQIVVLSIALVCIFILVFSLFHKSATKDSANPPLTNVLTDSISQIVSACPGEIGVAVIVNNRDTVKVNNKSVYPMMSVFKVHQALALCNDFDNKGISLDTLVNINRDKLDPKTWSPMLKDYSGPVISLTVRDLLRYTLTQSDNNASNLMFKDMVNVAQTDSFIATLIPRSSFQIAYTEEEMSADHNKAYSNYTSPLGAAMLMNRLFTEGLIDDEKQSFIKNTLKECKTGVDRIAAPLLDKEGVVIAHKTGSGDVNENGVLAAHNDVAYICLPNNISYTLAVFVKDFKGNESQASQYVAHISAVVYSLLMQTSVKS UPDATED category_aro_description with CfxA beta-lactamases are class A beta-lactamases. " 1897 UPDATE tet(L) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with M11036.1 " 1890 UPDATE TEM-86 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ277415.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1891 UPDATE AAC(6')-Iih AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iih is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus hirae. UPDATED partial with 0 UPDATED sequence with ATGATTATCAGTGAGTTTGATCGTGATAATTTGGTTTTACGTGACCAATTAGCCGATCTTTTGAGATTGACTTGGCCAGATGAATACGGTGAACAGCCGATGAAAGAAGTAGAGCGACTGCTGGAAGATGAAAGGATCGCCGTCTCTGCAATCGAAGGAGATGAGCTGATTGGTTTTGTCGGTGCGATTCCACAATATGGTCAAACTGGTTGGGAACTGCATCCCTTAGTCGTCGAAAGTATGTACCGTAAGCAACAAGTTGGTACACGCCTAGTGAGTTATCTAGAAAAAGAGATTGCCTCACAAGGAGGAATCGTTGTCTATTTAGGAACTGATGATGTGGAAGGGCAAACAAGCTTGGCGATTGAAGAAGACCTGTTTGAAGATACCTTTGACAAGCTTGAAACGATTCAAAACAGGAAAGATCATCCTTATGAATTCTATGAGAAACTTGGCTATCAGATCGTTGGGGTAATTCCGGATGCGAATGGCTGGAACAAGCCAGATATTTGGATGGCCAAACGAATTGCTAGAAAACATGGAAGTGAATGA UPDATED fmax with 562 UPDATED accession with AJ584701.2 UPDATED fmin with 10 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterococcus durans UPDATED NCBI_taxonomy_id with 53345 UPDATED NCBI_taxonomy_cvterm_id with 39522 UPDATED accession with CAE50926.1 UPDATED sequence with MIISEFDRDNLVLRDQLADLLRLTWPDEYGEQPMKEVERLLEDERIAVSAIEGDELIGFVGAIPQYGQTGWELHPLVVESMYRKQQVGTRLVSYLEKEIASQGGIVVYLGTDDVEGQTSLAIEEDLFEDTFDKLETIQNRKDHPYEFYEKLGYQIVGVIPDANGWNKPDIWMAKRIARKHGSE " 1892 UPDATE OXA-114a carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU188842.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1893 UPDATE SHV-127 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ390809.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4691 UPDATE IMP-64 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4922 UPDATE OXA-596 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2134 UPDATE CMY-36 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description "UPDATED ARO_description with CMY-36 is a beta-lactamase found in Klebsiella pneumoniae. " 4692 UPDATE IMP-65 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4695 UPDATE IMP-69 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4694 UPDATE IMP-67 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4697 UPDATE IMP-71 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4696 UPDATE IMP-70 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4699 UPDATE IMP-74 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4698 UPDATE IMP-73 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4929 UPDATE OXA-603 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4928 UPDATE OXA-602 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 955 UPDATE SHV-96 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF373971.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 954 UPDATE APH(3')-IIb antibiotic inactivation; aminoglycoside antibiotic; paromomycin; kanamycin A; APH(3'); gentamicin B; ribostamycin; G418; neomycin; butirosin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-IIb is a chromosomal-encoded aminoglycoside phosphotransferase in P. aeruginosa. UPDATED accession with X90856.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 957 UPDATE tet(G) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AF133139.1 " 2139 UPDATE vanSD glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSD, is a mutated vanS variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. UPDATED accession with EU999036.1 UPDATED accession with ACM47284.1 UPDATED model_name with vanS gene in vanD cluster UPDATED ARO_name with vanS gene in vanD cluster " 1967 UPDATE OXA-116 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU220744.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5181 UPDATE OXA-884 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5161 UPDATE OXA-864 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5162 UPDATE OXA-865 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5163 UPDATE OXA-866 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5164 UPDATE OXA-867 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5165 UPDATE OXA-868 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5166 UPDATE OXA-869 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5167 UPDATE OXA-870 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5168 UPDATE OXA-871 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5169 UPDATE OXA-872 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1686 UPDATE OXA-34 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF350424.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4803 UPDATE OXA-114c carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4941 UPDATE OXA-615 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2781 UPDATE porin OmpC penam; carbapenem; penem; cephaloridine; reduced permeability to antibiotic; cefazolin; cephalosporin; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; model_sequences; ARO_category "UPDATED accession with KY086517.1 UPDATED accession with APB87301.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4575 UPDATE CVI-1 carbapenem; antibiotic inactivation; CVI beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 2780 UPDATE FosA7 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; ARO_description "UPDATED ARO_description with FosA7 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. " 3429 UPDATE OXA-262 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3428 UPDATE OXA-261 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2783 UPDATE Vibrio cholerae OmpT peptide antibiotic; BPI; General Bacterial Porin with reduced permeability to peptide antibiotics; reduced permeability to antibiotic; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAAAAAACTCTATTAGCACTCGCAGTGCTTGCAGCCGCAGGCTCTGTAAACGCAGCTGAAATTCTAAAATCAGATGCTGGCACTGTTGATTTTTACGGTCAGCTACGTACAGAATTGAAATTCTTAGAAGATAAAGATCCAACAATTGGTTCTGGTTCTTCGCGCGCTGGTGTTGATGCAAACTACACCGTTAACGATAGCTTAGCGTTACAAGGTAAAGTGGAATTCGCACTAAAAGACAGTGGCGATATGTATGTTCGTAACCACATTCTTGGTGTAAAAACTAATTTTGGTAAGTTTAGCTTTGGTAAACAATGGACTACATCTGACGATGTATACGGTGCTGACTACTCTTATTTCTTTGGTGGTACAGGTCTTCGTTACGGCACACTGTCTGATGCACTACACGATTCTCAAGTCAAGTATGTTTACGAAGCTGACAGCTTCTGGGTTAAAGCTGGTTACGGTTTTCCAGAAGATAATGCAAAGCAAGAGCTAGCAGAACTGTATGTAGGTGCAACATTTGGTGATTTGGCTGTGCACGCTGGTGGTGGTCAAAACCGTGATAAAGCATTCAAAGTTGGTAGTAATACGGTTGGCACAACAACCACAGATATTAAAGCTGACGTAACAAATAGTTACTTTGAAGTGACAGGTGAGTACACTATTGGTGATGCACTGATTGGTGTTACTTACTACAACGCAGAACTAGATGTAGAAAATAACCCACTAGTGATCGATGAAGACGCTATTTCTGTTGCTGGTACATACAAAGTTGCTGACAAGACAAAATTGTATGCTGGCTATGAGTATGTAATGCAAGAAGCGAACACTGGCGCAGATGAAGATGGTACTCTTGTTTACCTAGGTGTTGAATACAAATTTGCAAGCTGGGCTCGTGTATATGCTGAGTATGGCTACGGCGATGGTACAACTCTGGGTTACACCAACAAGGGTTCTGACGCAGAAGTTAAAGCAACGAAAGTCGACAGCGCTAATAACTTTGGTATCGGCGCTCGTATCTACTGGTAA UPDATED fmax with 1821 UPDATED accession with AF079766.2 UPDATED fmin with 786 UPDATED strand with + UPDATED NCBI_taxonomy_name with Vibrio cholerae UPDATED NCBI_taxonomy_id with 666 UPDATED NCBI_taxonomy_cvterm_id with 36789 UPDATED accession with AAC28105.1 UPDATED sequence with MKKTLLALAVLAAAGSVNAAEILKSDAGTVDFYGQLRTELKFLEDKDPTIGSGSSRAGVDANYTVNDSLALQGKVEFALKDSGDMYVRNHILGVKTNFGKFSFGKQWTTSDDVYGADYSYFFGGTGLRYGTLSDALHDSQVKYVYEADSFWVKAGYGFPEDNAKQELAELYVGATFGDLAVHAGGGQNRDKAFKVGSNTVGTTTTDIKADVTNSYFEVTGEYTIGDALIGVTYYNAELDVENNPLVIDEDAISVAGTYKVADKTKLYAGYEYVMQEANTGADEDGTLVYLGVEYKFASWARVYAEYGYGDGTTLGYTNKGSDAEVKATKVDSANNFGIGARIYW " 3423 UPDATE OXA-185 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3422 UPDATE OXA-158 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3421 UPDATE OXA-157 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3420 UPDATE OXA-156 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3427 UPDATE OXA-260 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3426 UPDATE OXA-259 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3425 UPDATE OXA-252 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3424 UPDATE OXA-234 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-234 is a beta-lactamase found in Acinetobacter baumannii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2002 UPDATE Bacillus pumilus cat86 antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with cat86 is a chromosome-encoded variant of the cat gene found in Bacillus pumilus. UPDATED accession with K00544.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 4417 UPDATE CARB-31 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2000 UPDATE TEM-24 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with X65253.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2001 UPDATE OXA-250 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-250 is a beta-lactamase found in A. baumannii. UPDATED accession with HE963771.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2004 UPDATE TEM-189 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN254627.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2005 UPDATE CTX-M-89 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-89 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with FJ971899.1 " 4585 UPDATE EAM-1 carbapenem; antibiotic inactivation; EAM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4587 UPDATE EBR-4 carbapenem; penam; cephalosporin; EBR beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4586 UPDATE EBR-3 carbapenem; penam; cephalosporin; EBR beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4853 UPDATE OXA-518 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4852 UPDATE OXA-517 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4851 UPDATE OXA-516 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4850 UPDATE OXA-515 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4414 UPDATE CARB-28 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4413 UPDATE CARB-27 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1855 UPDATE CTX-M-72 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-72 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY847148.1 " 4943 UPDATE OXA-617 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4411 UPDATE CARB-25 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 937 UPDATE OXA-242 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-242 is a beta-lactamase found in A. baumannii. UPDATED accession with JX025022.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4410 UPDATE CARB-24 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4825 UPDATE OXA-193 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3557 UPDATE MIR-23 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; ARO_category "UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 3555 UPDATE AST-1 penam; antibiotic inactivation; cephalosporin; AST Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3554 UPDATE ARL-6 penam; antibiotic inactivation; ARL Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3553 UPDATE ARL-5 penam; antibiotic inactivation; ARL Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3551 UPDATE ARL-3 penam; antibiotic inactivation; ARL Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3550 UPDATE ARL-2 penam; antibiotic inactivation; ARL Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 668 UPDATE CTX-M-65 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-65 is a beta-lactamase found in Escherichia coli. UPDATED accession with EF418608.1 " 3559 UPDATE BCL-1 penam; antibiotic inactivation; BCL Beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with BCL-1 is a class A beta-lactamase found in Alkalihalobacillus clausii. UPDATED NCBI_taxonomy_name with Alkalihalobacillus clausii UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 624 UPDATE Mycobacterium leprae rpoB mutations conferring resistance to rifampicin rifampin; rifapentine; rifabutin; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); antibiotic target replacement; antibiotic target alteration; rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with Point mutations that occurs in Mycobacterium leprae rpoB resulting in resistance to rifampicin. UPDATED accession with AL450380.1 " 1263 UPDATE QnrB56 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB56 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JX259317.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 666 UPDATE CTX-M-34 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-34 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY515297.1 " 2176 UPDATE glycopeptide resistance gene cluster VanN glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; ARO_description "UPDATED ARO_description with Homologous to vanC, contains a D-Ala-D-Ser ligase. The plasmid-located vanM gene cluster is inducible and confers low resistance to vancomycin. vanN organisms remain susceptible to teicoplanin. Gene orientation: N(XY)TRS. " 504 UPDATE TEM-52 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y13612.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 665 UPDATE TEM-10 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF093512.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4944 UPDATE OXA-618 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2177 UPDATE glycopeptide resistance gene cluster VanA glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vancomycin; teicoplanin; ARO_description "UPDATED ARO_description with This inducible cluster confers high resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. The vanA gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSHAXYZ. " 2910 UPDATE OXA-665 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Beta-lactamase found in Acinetobacter rudis efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2912 UPDATE OXA-274 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1798 UPDATE SHV-183 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HG934764.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2914 UPDATE Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin antibiotic target alteration; antibiotic target replacement; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifamycin antibiotic; model_name "UPDATED model_name with Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin " 719 UPDATE CMY-33 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-33 is a beta-lactamase found in Escherichia coli. UPDATED accession with EU496816.1 " 718 UPDATE LRA-8 penam; antibiotic inactivation; subclass B3 LRA beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LRA-8 is a beta-lactamase isolated from soil samples in Alaska. UPDATED accession with EU408349.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 717 UPDATE CTX-M-100 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-100 is a beta-lactamase found in Escherichia coli. UPDATED accession with FR682582.1 " 1792 UPDATE DHA-20 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087848.1 " 1791 UPDATE TEM-164 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU274580.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 713 UPDATE CTX-M-81 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-81 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGGTGACAAAGAGAGTGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTGCTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCGCAGATAATACGCAGGTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTGAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCCAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACCATGACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACCATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGTGGGTGATAAGACCGGCAGCGGCGACTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTGGTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTGGCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA UPDATED fmax with 876 UPDATED accession with EU136031.3 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with ABV57756.3 UPDATED sequence with MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLEQSETQKQLLNQPVEIQPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDHTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL " 712 UPDATE catB2 antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with catB2 is a plasmid-encoded variant of the cat gene found in Escherichia coli, Salmonella enteritidis and Pasteurella multocida. UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1795 UPDATE VEB-2 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VEB-2 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AY027870.1 UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 1794 UPDATE tmrB nucleoside antibiotic; reduced permeability to antibiotic; tunicamycin; tunicamycin resistance protein; ARO_description "UPDATED ARO_description with tmrB is an ATP-binding tunicamycin resistance protein found in Bacillus subtilis. " 4967 UPDATE OXA-642 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 661 UPDATE VIM-5 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-5 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AY144612.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5186 UPDATE OXA-889 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4966 UPDATE OXA-640 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 505 UPDATE Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol antibiotic efflux; polyamine antibiotic; Ethambutol resistant iniC; efflux pump complex or subunit conferring antibiotic resistance; ethambutol; antibiotic target alteration; model_sequences; ARO_category "UPDATED accession with AL123456.1 UPDATED category_aro_description with Mutations that occurs on the iniC genes resulting in the resistance to ethambutol. " 1264 UPDATE smeC penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with smeC is an outer membrane multidrug efflux protein of the smeABC complex in Stenotrophomonas maltophilia. UPDATED accession with AF173226.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 917 UPDATE SHV-186 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM233165.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1906 UPDATE CTX-M-17 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-17 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY033516.1 " 916 UPDATE OXA-36 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF300985.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1066 UPDATE TEM-118 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY130285.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4390 UPDATE BlaB-29 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4961 UPDATE OXA-635 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1669 UPDATE vanZF vanZ; glycopeptide resistance gene cluster; antibiotic target alteration; glycopeptide antibiotic; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanZF, is a vanZ variant found in the vanF gene cluster. UPDATED accession with AF155139.1 UPDATED model_name with vanZ gene in vanF cluster UPDATED ARO_name with vanZ gene in vanF cluster " 1668 UPDATE CMY-68 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JN714480.1 " 1667 UPDATE TEM-80 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF347054.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1666 UPDATE vanXB glycopeptide antibiotic; glycopeptide resistance gene cluster; vanX; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXB, is a vanX variant found in the vanB gene cluster. UPDATED accession with U35369.1 UPDATED model_name with vanX gene in vanB cluster UPDATED ARO_name with vanX gene in vanB cluster " 1665 UPDATE ramA penem; tetracycline antibiotic; antibiotic efflux; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; reduced permeability to antibiotic; carbapenem; cephalosporin; cefalotin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; tigecycline; glycylcycline; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; model_sequences; ARO_category "UPDATED accession with JQ727668.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 1664 UPDATE adeK antibiotic efflux; imipenem; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; trimethoprim; rifamycin antibiotic; penem; macrolide antibiotic; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; ticarcillin; tetracycline antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; model_sequences "UPDATED accession with AY769962.1 " 1663 UPDATE ACC-1 penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACC-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AJ133121.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1662 UPDATE OKP-B-17 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-17 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAGGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGCTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGTGATACCCCGGCGACCATGGTCGAGCGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAA UPDATED fmax with 885 UPDATED accession with AM850919.2 UPDATED fmin with 24 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12357.2 UPDATED sequence with MRYVRLCLISLIAALPLAVFASPQPLEQIKISEGQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTPATMVERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1661 UPDATE CARB-8 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-8 is a beta-lactamase found in Oligella urethralis. UPDATED accession with AY178993.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1660 UPDATE OXA-375 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 590 UPDATE IND-6 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-6 is a beta-lactamase found in Chryseobacterium indologenes. UPDATED partial with 0 UPDATED sequence with ATGAAAAGAAGAATTCAGTTCTTTATGGTTTCAATGATGCTTACCCCATTATTCAGTGCCCAGGTAAAAGATTTTGTAATTGAACCGCCAATAAAAAAGAACTTATATATTTATAAAACTTTCGGAGTGTTCGGGGGAAAAGAATATTCTGCCAATTCAGTGTATCTTGTCACCAAAACCGGGGTTGTTTTATTTGATGTTCCCTGGGAAAAAGCGCAATACCAAAGCCTGATGGATACCATCAAAAAACGTCATAATTTACCTGTTGTTGCGGTATTTGCGACACATTCCCATGATGACCGGGCAGGAGATTTAAGCTTTTTCAATAATAAAGGAATTAAAACCTATGCTACTCCTAAAACCAATCAATTTCTGAAAAGAGACGGAAAGGCTACTTCTACAGAGCTCATTAAGCCCGGAAAACCTTACCGCTTTGGCGGAGAGGAATTTGTAGTGGATTTTCTTGGTGAAGGGCATACTGCCGATAATGTAGTGGTATGGTTTCCAAAATATAAAGTGCTGGATGGCGGCTGCCTTGTAAAAAGCAATTCAGCTACCGATTTAGGGTATATCAAAGAAGCTAATCTAGAGCAATGGCCTAAAACCATGCATAAACTGAAAACAAAATATTCAGAAGCAGTATTAATTATTCCCGGACATGATGAATGGAAAGGCGGCGGGCACGTTGAACATACTTTGGAGCTGCTGGATAAGAAATAA UPDATED fmax with 1011 UPDATED accession with AM087455.2 UPDATED fmin with 291 UPDATED strand with + UPDATED NCBI_taxonomy_name with Chryseobacterium indologenes UPDATED NCBI_taxonomy_id with 253 UPDATED NCBI_taxonomy_cvterm_id with 36916 UPDATED accession with CAJ32373.2 UPDATED sequence with MKRRIQFFMVSMMLTPLFSAQVKDFVIEPPIKKNLYIYKTFGVFGGKEYSANSVYLVTKTGVVLFDVPWEKAQYQSLMDTIKKRHNLPVVAVFATHSHDDRAGDLSFFNNKGIKTYATPKTNQFLKRDGKATSTELIKPGKPYRFGGEEFVVDFLGEGHTADNVVVWFPKYKVLDGGCLVKSNSATDLGYIKEANLEQWPKTMHKLKTKYSEAVLIIPGHDEWKGGGHVEHTLELLDKK UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 592 UPDATE lmrB efflux pump complex or subunit conferring antibiotic resistance; ATP-binding cassette (ABC) antibiotic efflux pump; antibiotic efflux; lincosamide antibiotic; ARO_description "UPDATED ARO_description with lmrB is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Bacillus subtilis. " 1083 UPDATE OXA-323 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203097.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 594 UPDATE QnrB41 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB41 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JN166690.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1081 UPDATE IMP-30 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-30 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with DQ522237.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1080 UPDATE SHV-158 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121125.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3142 UPDATE MCR-1.3 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with An MCR-1 polymyxin resistance gene variant identified from a poultry Raoultella planticola isolate. " 3144 UPDATE MCR-8.1 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; model_name "UPDATED model_name with MCR-8.1 " 3145 UPDATE MCR-7.1 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with A novel plasmid-mediated colistin-resistant phosphoethanolamine transferase identified from a poultry isolate of Klebsiella pneumoniae. " 1709 UPDATE TEM-115 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF535127.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2824 UPDATE Mycoplasma pneumoniae 23S rRNA mutation conferring resistance to erythromycin antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; erythromycin; ARO_description "UPDATED ARO_description with Point mutation in the 23S rRNA of Mycoplasma pneumoniae shown to confer resistance to erythromycin. " 2825 UPDATE Halobacterium halobium 23S rRNA mutation conferring resistance to chloramphenicol antibiotic target alteration; phenicol antibiotic; 23S rRNA with mutation conferring resistance to phenicol antibiotics; chloramphenicol; ARO_description; ARO_category "UPDATED ARO_description with Point mutation in the 23S rRNA of Halobacterium halobium shown to confer resistance to chloramphenicol. UPDATED category_aro_description with Point mutations in the 23S rRNA subunit shown clinically to confer resistance to phenicol class antibiotics, including chloramphenicol and florfenicol, by disrupting antibiotic binding-site affinity. " 2826 UPDATE Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics pristinamycin IA; josamycin; 23S rRNA with mutation conferring resistance to macrolide antibiotics; virginiamycin M1; macrolide antibiotic; antibiotic target alteration; streptogramin antibiotic; 23S rRNA with mutation conferring resistance to streptogramins antibiotics; tylosin; ARO_description; ARO_category "UPDATED ARO_description with Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolides and streptogramins types of antibiotics. UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 2827 UPDATE Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid Para-aminosalicylic acid; aminosalicylate resistant dihydrofolate reductase; antibiotic target replacement; ARO_category "UPDATED category_aro_name with Para-aminosalicylic acid UPDATED category_aro_description with Para-aminosalicylic acid (PAS) is an anti-tubercular antibiotic agent, often used in conjunction with Isoniazid for treatment of M. tuberculosis infections. PAS diminishes bacterial cell growth by limiting folic acid production. " 2820 UPDATE Chlamydia trachomatis 23S rRNA with mutation conferring resistance to macrolide antibiotics antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; ARO_description "UPDATED ARO_description with Point mutation in the 23S rRNA of Chlamydia trachomatis shown to confer resistance to macrolide type antibiotics. " 2822 UPDATE Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; ARO_description; model_name "UPDATED ARO_description with Point mutation in the 23S rRNA of Mycoplasma hominis shown to confer resistance to macrolide type antibiotics. UPDATED model_name with Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics " 2823 UPDATE Mycoplasma fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Point mutation in the 23S rRNA of Mycoplasmopsis fermentans shown to confer resistance to macrolide type antibiotics. UPDATED NCBI_taxonomy_name with Mycoplasmopsis fermentans PG18 UPDATED model_name with Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics UPDATED ARO_name with Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics " 3382 UPDATE aadS antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); ARO_description; ARO_category "UPDATED ARO_description with A novel Tn4551 streptomycin-resistance gene that was phenotypically silent in wild-type Bacteroides; expression could be activated by a trans-acting chromosomal mutation. UPDATED category_aro_description with Nucelotidylylation of streptomycin at the hydroxyl group at position 6. " 3380 UPDATE Clostridioides difficile rpoC with mutation conferring resistance to vancomycin vancomycin-resistant beta prime subunit of RNA polymerase (rpoC); glycopeptide antibiotic; antibiotic target alteration; vancomycin; ARO_description; ARO_category "UPDATED ARO_description with Point mutations in the rpoC region of Clostridioides difficile which confer resistance to vancomycin. UPDATED category_aro_description with Point mutations in rpoC, an RNA polymerase subunit, which confer resistance to vancomycin. " 3381 UPDATE aadA27 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; ARO_category "UPDATED ARO_description with Small mobilizable plasmid pALWED1.8 containing a novel variant of the streptomycin/spectinomycin resistance gene. UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1490 UPDATE SHV-107 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM941848.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5199 UPDATE OXA-907 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3389 UPDATE MCR-1.13 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli. " 1409 UPDATE CMY-6 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-6 is a beta-lactamase found in Escherichia coli. UPDATED accession with AJ011293.1 " 1408 UPDATE TEM-124 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY327540.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5134 UPDATE OXA-832 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4622 UPDATE GES-39 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1402 UPDATE OXA-390 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4963 UPDATE OXA-637 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1407 UPDATE CMY-62 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JF460796.1 " 1406 UPDATE OXA-121 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF057027.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1086 UPDATE CMY-41 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-41 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AB429270.1 " 1491 UPDATE lnuF antibiotic inactivation; lincosamide nucleotidyltransferase (LNU); lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with lnuF is an integron-mediated nucleotidyltransferase found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGCTTCAGCAGAAAATGATCGAACGCTTCAAGGAAGCTTGCCATGAGGATGCACGAATAATCGCGGCGCTGATGTTCGGCTCATTTGCTATCGGAGAGGGTGACGAGTTCTCTGATATCGAATTTGCAGTGTTCATCCAGAATAATCATTTTGAAAATTTCGATCAGCGCTCGTGGCTTAATGCTGTAAGTCCGGTTGCAGCTTACTTTCCGGATGACTTCGGCCACCACACCGCGCTTTTTGAAAACGGCATTCGCGGTGAATTCCATTTCATGCGAAAATCGGACATACCGGTCATTTCCACTTGGCAAGGCTACGGGTGGTTTCCCTCGCTTGAGGAGGCTGTTTTGTTGGACCGATCAGGAGAGTTGTCAAGGTACGCGAGTGCTCTCGTGGGCAGTCCCCCGAAACGTGAAGGCGCGCCGCTGGTGGAAGGACTTGTATTGAACCTCATCAGCCTGATGCTCTTTGGGGCAAATCTTTTAAATCGGGGAGAGTATGCTCGCGCCTGGGCTTTGCTCAGCAAAGCACATGAAAACTTACTCAAGTTGGTTCGCCTCCATGAAGGGGCAACAGACCACTGGCCGACACCTTCACGCGCGCTCGAAAAGGATGTCTCGGAGGACTCGTATAATCGCTACCTGGCATGCACAGGCAGCGCGGAACCAAAAGCACTATGTGTAGCCTATCATGAAACGTGGAAGTGGAGTCTCGAATTGTTCAGGAGTGTGGCTGGACCTCTGAATATCGAGCTTCCGAGAATTGTAATTGCGCAGACAAAAAGGTTGCTAAATGAATCTGCGACGCCGCACAACAAGTAA UPDATED fmax with 2142 UPDATED accession with AJ561197.2 UPDATED fmin with 1320 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with CAD91132.1 UPDATED sequence with MLQQKMIERFKEACHEDARIIAALMFGSFAIGEGDEFSDIEFAVFIQNNHFENFDQRSWLNAVSPVAAYFPDDFGHHTALFENGIRGEFHFMRKSDIPVISTWQGYGWFPSLEEAVLLDRSGELSRYASALVGSPPKREGAPLVEGLVLNLISLMLFGANLLNRGEYARAWALLSKAHENLLKLVRLHEGATDHWPTPSRALEKDVSEDSYNRYLACTGSAEPKALCVAYHETWKWSLELFRSVAGPLNIELPRIVIAQTKRLLNESATPHNK " 1335 UPDATE QnrB8 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB8 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED partial with 0 UPDATED sequence with ATGACTCTGGCATTAGTTGGCGAAAAAATTGACAGAAACCGCTTCACCGGTGAAAAAGTTGAAAATAGCACTTTTTTTAACTGTGATTTTTCGGGTGCCGACCTTAGCGGTACTGAATTTATCGGCTGTCAGTTCTATGATCGAGAAAGCCAGAAAGGGTGCAATTTCAGTCGCGCAATACTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAACGTCAGTGCGTTGGGCATAGAAATTCGCCACTGCCGCGCACAGGGTGCAGATTTTCGCGGCGCAAGTTTCATGAATATGATCACCACGCGCACCTGGTTTTGCAGCGCATATATCACTAATACCAATCTAAGCTACGCCAACTTTTCGAAGGCCGTGCTTGAAAAGTGCGAATTGTGGGAAAATCGCTGGATGGGAACTCAGGTACTGGGTGCGACGTTGAGTGGTTCCGATCTCTCCGGTGGCGAGTTTTCGTCGTTCGACTGGCGGACGGCAAATTTCACGCACTGTGATTTGACCAATTCAGAACTGGGTGATTTAGATATTCGGGGCGTCGATTTACAAGGTGTCAAATTGGACAACTATCAGGCCGCATTGCTCATGGAACGTCTTGGCATCGCTGTGATTGGCTAG UPDATED fmax with 645 UPDATED accession with EU043312.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Citrobacter freundii UPDATED NCBI_taxonomy_id with 546 UPDATED NCBI_taxonomy_cvterm_id with 36915 UPDATED accession with ABW03157.2 UPDATED sequence with MTLALVGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAILKDAIFKSCDLSMADFRNVSALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKAVLEKCELWENRWMGTQVLGATLSGSDLSGGEFSSFDWRTANFTHCDLTNSELGDLDIRGVDLQGVKLDNYQAALLMERLGIAVIG UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1334 UPDATE SHV-126 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ390808.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1336 UPDATE BcII penam; antibiotic inactivation; cephalosporin; Bc beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Bacillus cereus beta-lactamase II is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 5/B/6. UPDATED accession with M19530.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 690 UPDATE OXA-347 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-347 is a beta-lactamase found in Enterobacteriaceae. UPDATED accession with JN086160.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1333 UPDATE vanHD glycopeptide antibiotic; glycopeptide resistance gene cluster; vanH; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanHD, is a vanH variant in the vanD gene cluster. UPDATED accession with AY082011.1 UPDATED model_name with vanH gene in vanD cluster UPDATED ARO_name with vanH gene in vanD cluster " 444 UPDATE AAC(6')-Ib-Suzhou AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ib-Suzhou is an aminoglycoside acetyltransferase in E. cloacae and K. pneumoniae. UPDATED accession with EU085533.1 " 1545 UPDATE Escherichia coli gyrA conferring resistance to fluoroquinolones grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; fluoroquinolone resistant gyrA; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description "UPDATED ARO_description with Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. " 4947 UPDATE OXA-621 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4623 UPDATE GES-40 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1432 UPDATE Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol ethambutol resistant embC; antibiotic target alteration; ethambutol; polyamine antibiotic; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance. UPDATED partial with 0 UPDATED sequence with ATGGCTACCGAAGCCGCCCCACCCCGTATCGCCGTCCGGCTACCATCTACCTCCGTGCGCGACGCGGGAGCAAACTACCGGATCGCCCGGTACGTCGCTGTGGTGGCGGGTCTGCTAGGCGCTGTGCTGGCCATCGCCACCCCACTGCTGCCGGTCAACCAGACCACCGCGCAATTGAACTGGCCCCAAAACGGCACGTTCGCCAGTGTCGAGGCACCGCTGATTGGCTACGTGGCCACCGACTTGAACATCACCGTCCCCTGCCAGGCCGCCGCCGGACTGGCCGGATCGCAGAACACCGGCAAGACGGTGTTGTTGTCAACGGTGCCCAAGCAGGCGCCTAAGGCCGTCGATCGCGGGCTGCTGCTGCAACGGGCCAACGACGACCTGGTGCTTGTGGTGCGTAATGTCCCGTTGGTCACCGCCCCGCTGAGTCAGGTGCTCGGCCCGACCTGTCAGCGGTTGACATTCACCGCGCACGCCGATCGGGTCGCCGCCGAATTCGTCGGACTGGTGCAGGGACCCAATGCTGAGCACCCCGGTGCACCGCTGCGCGGTGAGCGCAGCGGCTACGACTTCCGCCCGCAGATCGTCGGGGTGTTCACCGACCTGGCCGGGCCGGCGCCACCGGGTCTGAGCTTCTCGGCGAGCGTGGATACCCGCTACAGCAGCAGCCCCACGCCGCTGAAGATGGCCGCCATGATCCTCGGGGTAGCGCTCACCGGCGCCGCCCTGGTGGCGCTGCACATCCTGGACACCGCCGACGGCATGCGGCACCGGCGGTTCCTGCCCGCGCGCTGGTGGTCGACCGGCGGTCTGGACACCCTGGTTATCGCCGTGCTGGTGTGGTGGCATTTCGTCGGGGCCAACACCTCCGACGACGGCTACATCCTGACCATGGCCCGGGTGTCCGAGCATGCGGGCTATATGGCCAACTACTACCGCTGGTTCGGCACACCCGAGGCGCCTTTCGGCTGGTACTACGACCTGCTGGCGCTGTGGGCTCATGTCAGCACGGCCAGTATCTGGATGCGCCTACCCACCCTGGCGATGGCGCTCACCTGCTGGTGGGTAATCAGCCGTGAGGTCATTCCCCGGCTGGGGCACGCCGTCAAGACGAGCCGGGCAGCGGCGTGGACGGCGGCGGGCATGTTTCTGGCTGTCTGGCTGCCGCTGGACAACGGCCTTCGGCCCGAGCCGATCATCGCCCTGGGCATCCTGCTGACCTGGTGCTCGGTGGAGCGGGCGGTGGCCACCAGCCGGCTGCTGCCGGTGGCAATCGCCTGCATCATCGGTGCCTTGACCCTGTTCTCCGGGCCGACGGGCATCGCCTCGATCGGTGCGCTGCTGGTCGCGATCGGGCCGCTACGGACCATCCTGCACCGGCGTTCCAGGCGGTTCGGCGTGCTACCACTGGTGGCGCCGATCCTGGCCGCGGCCACCGTCACCGCGATCCCGATCTTTCGTGATCAGACCTTCGCGGGCGAGATCCAGGCCAACCTCCTCAAGCGTGCCGTAGGGCCCAGCCTGAAGTGGTTCGACGAACACATCCGCTACGAGCGGCTGTTCATGGCCAGCCCCGACGGCTCGATCGCCCGCCGCTTCGCCGTGCTGGCCTTGGTGCTGGCGCTCGCGGTATCGGTGGCAATGTCGTTACGTAAGGGCCGCATTCCAGGTACCGCTGCTGGACCGAGCCGCCGCATCATCGGCATCACGATCATTTCCTTCCTCGCGATGATGTTCACCCCGACAAAGTGGACCCATCACTTCGGGGTGTTCGCGGGGTTGGCCGGGTCGCTGGGGGCGCTTGCCGCGGTCGCGGTGACGGGCGCTGCGATGCGCTCGCGGCGGAACCGGACCGTGTTCGCCGCCGTGGTGGTCTTCGTGTTGGCCCTGTCGTTCGCCAGTGTCAACGGCTGGTGGTACGTGTCCAACTTCGGTGTGCCATGGTCGAACTCGTTTCCGAAGTGGCGATGGTCGCTTACCACCGCACTCCTCGAGCTGACGGTGCTGGTGCTGCTGCTAGCGGCATGGTTCCACTTCGTCGCCAACGGTGACGGGCGCCGAACAGCCAGGCCAACCCGGTTTAGGGCACGACTAGCCGGAATTGTCCAGTCCCCGTTGGCAATTGCCACGTGGTTGCTGGTGCTTTTCGAGGTGGTATCGCTGACCCAGGCGATGATTTCCCAGTACCCGGCGTGGTCGGTTGGCCGGTCTAACCTACAGGCTTTGGCCGGCAAGACCTGCGGGCTGGCCGAAGACGTGCTGGTGGAGCTGGATCCCAACGCAGGCATGCTGGCGCCGGTGACCGCGCCGTTGGCCGACGCCCTGGGAGCCGGCCTGTCTGAAGCCTTCACACCCAACGGCATTCCCGCCGACGTCACCGCCGACCCGGTGATGGAACGTCCAGGGGATCGCAGTTTCCTCAACGACGACGGGCTGATCACCGGCAGCGAACCCGGCACCGAAGGGGGCACCACGGCCGCACCGGGAATCAACGGCTCCCGCGCCCGGCTGCCCTACAACCTGGACCCGGCCCGTACACCGGTGCTGGGCAGCTGGCGAGCCGGCGTGCAGGTGCCCGCCATGCTGCGGTCGGGCTGGTACCGGCTGCCCACCAACGAGCAGCGGGACAGGGCGCCGCTGCTGGTGGTGACGGCGGCCGGGCGATTCGACTCCCGCGAGGTCCGGTTGCAGTGGGCCACCGACGAGCAAGCGGCCGCCGGACACCACGGTGGGTCGATGGAATTCGCCGACGTCGGTGCCGCGCCGGCCTGGCGCAACCTGCGCGCACCACTGTCCGCCATCCCGAGCACCGCCACCCAGGTCCGGTTGGTCGCCGACGACCAGGATCTGGCGCCGCAGCACTGGATCGCCCTCACACCACCGCGGATTCCGCGGGTGCGCACGCTGCAGAACGTGGTGGGCGCAGCGGATCCGGTGTTCCTGGACTGGCTGGTGGGGCTGGCATTCCCCTGCCAACGCCCGTTCGGCCACCAATACGGCGTCGACGAGACACCCAAGTGGCGGATCCTGCCGGACCGGTTCGGCGCCGAAGCCAACTCACCGGTGATGGATCACAATGGCGGTGGCCCGCTGGGCATCACCGAGCTGCTGATGCGCGCAACCACGGTGGCCAGCTACCTCAAAGACGACTGGTTTAGGGACTGGGGCGCGTTACAGCGGTTGACGCCTTACTACCCCGACGCCCAGCCCGCTGATCTGAACCTAGGAACGGTGACTCGCAGCGGGCTGTGGAGTCCGGCGCCGTTGCGCCGCGGCTAG UPDATED fmax with 4243325 UPDATED accession with CP003248.2 UPDATED fmin with 4240040 UPDATED strand with + UPDATED NCBI_taxonomy_name with Mycobacterium tuberculosis H37Rv UPDATED NCBI_taxonomy_id with 83332 UPDATED NCBI_taxonomy_cvterm_id with 39507 UPDATED accession with AFN51819.1 UPDATED sequence with MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLAIATPLLPVNQTTAQLNWPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGKTVLLSTVPKQAPKAVDRGLLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAHADRVAAEFVGLVQGPNAEHPGAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASVDTRYSSSPTPLKMAAMILGVALTGAALVALHILDTADGMRHRRFLPARWWSTGGLDTLVIAVLVWWHFVGANTSDDGYILTMARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVSTASIWMRLPTLAMALTCWWVISREVIPRLGHAVKTSRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATSRLLPVAIACIIGALTLFSGPTGIASIGALLVAIGPLRTILHRRSRRFGVLPLVAPILAAATVTAIPIFRDQTFAGEIQANLLKRAVGPSLKWFDEHIRYERLFMASPDGSIARRFAVLALVLALAVSVAMSLRKGRIPGTAAGPSRRIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSLGALAAVAVTGAAMRSRRNRTVFAAVVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWSLTTALLELTVLVLLLAAWFHFVANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEVVSLTQAMISQYPAWSVGRSNLQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAGLSEAFTPNGIPADVTADPVMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLPYNLDPARTPVLGSWRAGVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQWATDEQAAAGHHGGSMEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIALTPPRIPRVRTLQNVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEANSPVMDHNGGGPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTVTRSGLWSPAPLRRG UPDATED model_name with Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol " 4436 UPDATE CARB-52 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1631 UPDATE CTX-M-71 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-71 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with FJ815436.1 " 1543 UPDATE CMY-22 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with DQ256079.1 " 4425 UPDATE CARB-41 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 39 UPDATE AAC(3)-Ia antibiotic inactivation; AAC(3); plazomicin; sisomicin; gentamicin B; gentamicin C; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis. UPDATED partial with 0 UPDATED sequence with ATGGGCATCATTCGCACATGTAGGCTCGGCCCTGACCAAGTCAAATCCATGCGGGCTGCTCTTGATCTTTTCGGTCGTGAGTTCGGAGACGTAGCCACCTACTCCCAACATCAGCCGGACTCCGATTACCTCGGGAACTTGCTCCGTAGTAAGACATTCATCGCGCTTGCTGCCTTCGACCAAGAAGCGGTTGTTGGCGCTCTCGCGGCTTACGTTCTGCCCAGGTTTGAGCAGCCGCGTAGTGAGATCTATATCTATGATCTCGCAGTCTCCGGCGAGCACCGGAGGCAGGGCATTGCCACCGCGCTCATCAATCTCCTCAAGCATGAGGCCAACGCGCTTGGTGCTTATGTGATCTACGTGCAAGCAGATTACGGTGACGATCCCGCAGTGGCTCTCTATACAAAGTTGGGCATACGGGAAGAAGTGATGCACTTTGATATCGACCCAAGTACCGCCACCTAA UPDATED fmax with 5520 UPDATED accession with U12338.3 UPDATED fmin with 5055 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AAG15269.1 UPDATED sequence with MGIIRTCRLGPDQVKSMRAALDLFGREFGDVATYSQHQPDSDYLGNLLRSKTFIALAAFDQEAVVGALAAYVLPRFEQPRSEIYIYDLAVSGEHRRQGIATALINLLKHEANALGAYVIYVQADYGDDPAVALYTKLGIREEVMHFDIDPSTAT " 38 UPDATE APH(3')-Va antibiotic inactivation; aminoglycoside antibiotic; paromomycin; APH(3'); ribostamycin; G418; neomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-Va is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces fradiae. UPDATED accession with K00432.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 1492 UPDATE MOX-3 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; model_sequences; ARO_category "UPDATED accession with EU515248.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1057 UPDATE CTX-M-114 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with GQ351346.1 " 1100 UPDATE OXA-245 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-245 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with JX438001.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1241 UPDATE TEM-144 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM049399.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1534 UPDATE PER-5 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_description; ARO_category "UPDATED ARO_description with PER-5 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1245 UPDATE TEM-114 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY589495.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1244 UPDATE OXY-5-1 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-5-1 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ871869.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1531 UPDATE TEM-81 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF427127.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1530 UPDATE OXA-67 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ491200.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1249 UPDATE FOX-5 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with FOX-5 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY007369.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 648 UPDATE GES-4 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-4 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AB116260.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1632 UPDATE CTX-M-53 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-53 is a beta-lactamase found in Salmonella enterica. UPDATED partial with 0 UPDATED sequence with ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGTGGACGTACAGCAAAAACTTGCCGAATTAGAGCAGCAGTCGGGAGGAAGGCTGGGTGTGGCATTGATTAACACGGCGGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGTGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTCGAGATCAAAAAATCTGACCTGGTTAACTATAATCCGATTGCGGAAAAACACGTCAATGGGACGATGTCACTGGCTGAGCTCAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTTACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCTGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACGCTGCGTAATCTGACGCTGGGTAAAGCATTGGGTGACAGCCAACGGGCGCAGCTGGTGACGTGGATGAAAGGCAATACTACCGGTGCAGCGAGTATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGTACCACCAACGATATCGCGGTGATTTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCATTTACTTCACCCAGCCCCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAG UPDATED fmax with 6767 UPDATED accession with DQ268764.2 UPDATED fmin with 5891 UPDATED strand with + UPDATED NCBI_taxonomy_name with Salmonella enterica subsp. enterica serovar Westhampton UPDATED NCBI_taxonomy_id with 356621 UPDATED NCBI_taxonomy_cvterm_id with 35809 UPDATED accession with ABB72225.1 UPDATED sequence with MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELEQQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVIYFTQPQPKAESRRDVLASAAKIVTDGL " 1539 UPDATE aadA3 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli. UPDATED partial with 0 UPDATED sequence with ATGAGGGTAGCGGTGACCATCGAAATTTCGAACCAACTATCAGAGGTGCTAAGCGTCATTGAGCGCCATCTGGAATCAACGTTGCTGGCCGTGCATTTGTACGGCTCCGCAGTGGATGGCGGCCTGAAGCCATACAGCGATATTGATTTGTTGGTTACTGTGGCCGTAAAGCTTGATGAAACGACGCGGCGAGCATTGCTCAATGACCTTATGGAGGCTTCGGCTTTCCCTGGCGAGAGCGAGACGCTCCGCGCTATAGAAGTCACCCTTGTCGTGCATGACGACATCATCCCGTGGCGTTATCCGGCTAAGCGCGAGCTGCAATTTGGAGAATGGCAGCGCAATGACATTCTTGCGGGTATCTTCGAGCCAGCCATGATCGACATTGATCTAGCTATCCTGCTTACAAAAGCAAGAGAACATAGCGTTGCCTTGGTAGGTCCGGCAGCGGAGGAATTCTTTGACCCGGTTCCTGAACAGGATCTATTCGAGGCGCTGAGGGAAACCTTGAAGCTATGGAACTCGCAGCCCGACTGGGCCGGCGATGAGCGAAATGTAGTGCTTACGTTGTCCCGCATTTGGTACAGCGCAATAACCGGCAAAATCGCGCCGAAGGATGTCGCTGCCGACTGGGCAATAAAACGCCTACCTGCCCAGTATCAGCCCGTCTTACTTGAAGCTAAGCAAGCTTATCTGGGACAAAAAGAAGATCACTTGGCCTCACGCGCAGATCACTTGGAAGAATTTATTCACTACGTGAAAGGCGAGATCACCAAGGTAGTCGGCAAATAA UPDATED fmax with 2087 UPDATED accession with AF047479.2 UPDATED fmin with 1295 UPDATED strand with + UPDATED NCBI_taxonomy_name with Plasmid NR79 UPDATED NCBI_taxonomy_id with 2468 UPDATED NCBI_taxonomy_cvterm_id with 36872 UPDATED accession with AAC14728.1 UPDATED sequence with MRVAVTIEISNQLSEVLSVIERHLESTLLAVHLYGSAVDGGLKPYSDIDLLVTVAVKLDETTRRALLNDLMEASAFPGESETLRAIEVTLVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPAMIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLFEALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQPVLLEAKQAYLGQKEDHLASRADHLEEFIHYVKGEITKVVGK UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1538 UPDATE SHV-104 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU274581.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1493 UPDATE PER-6 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with PER-6 is a beta-lactamase found in Aeromonas allosaccharophila. UPDATED accession with GQ396303.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 339 UPDATE ANT(3'')-Ii-AAC(6')-IId fusion protein AAC(6'); antibiotic inactivation; ANT(3''); aminoglycoside antibiotic; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAGTAACGCAGTACCCGCCGAGATTTCGGTACAGCTATCACTGGCTCTCAACGCCATCGAGCGTCATCTGGAATCAACGTTGCTGGCCGTGCATTTGTACGGCTCTGCACTGGACGGTGGCCTGAAGCCATACAGTGATATTGATTTGCTGGTTACTGTGGCTGCACAGCTCGATGAGACTGTCCGACAAGCCCTGGTCGTAGATCTCTTGGAAATTTCTGCCTCCCCTGGCCAAAGTGAGGCTCTCCGCGCCTTGGAAGTTACCATCGTCGTGCATGGTGATGTTGTCCCTTGGCGTTATCCGGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGTAAAGACATTCTTGCGGGCATCTTCGAGCCCGCCACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGTAAGGCAGCATAGCCTTGCATTGGCAGGTTCGGCCGCAGAGGATTTCTTTAACCCAGTTCCGGAAGGCGATCTATTCAAGGCATTGAGCGACACTCTGAAACTATGGAATTCGCAGCCGGATTGGGAAGGCGATGAGCGGAATGTAGTGCTTACCTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCACCGAAGGATATCGTTGCCAACTGGGCAATTGAGCGTCTGCCAGATCAACATAAGCCCGTACTGCTTGAAGCCCGGCAGGCTTATCTTGGACGAGGAGAAGATTGCTTGGCCTCACGCGCGGATCAGTTGGCGGCGTTCGTTCACTTCGTGAAACATGAAGCCACTAAATTGCTTGGTGCCATGCCAGTGATGTCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA UPDATED fmax with 4946 UPDATED accession with AF453998.2 UPDATED fmin with 3554 UPDATED strand with + UPDATED NCBI_taxonomy_name with Serratia marcescens UPDATED NCBI_taxonomy_id with 615 UPDATED NCBI_taxonomy_cvterm_id with 36783 UPDATED accession with AAL51021.2 UPDATED sequence with MSNAVPAEISVQLSLALNAIERHLESTLLAVHLYGSALDGGLKPYSDIDLLVTVAAQLDETVRQALVVDLLEISASPGQSEALRALEVTIVVHGDVVPWRYPARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKVRQHSLALAGSAAEDFFNPVPEGDLFKALSDTLKLWNSQPDWEGDERNVVLTLSRIWYSAATGKIAPKDIVANWAIERLPDQHKPVLLEARQAYLGRGEDCLASRADQLAAFVHFVKHEATKLLGAMPVMSKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 3267 UPDATE Clostridioides difficile murG with mutation conferring resistance to vancomycin glycopeptide antibiotic; antibiotic target alteration; vancomycin; murG transferase; ARO_description "UPDATED ARO_description with Mutations in murG which confer resistance to vancomycin in Clostridioides difficile. " 4391 UPDATE BlaB-3 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 335 UPDATE Staphylococcus aureus parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; grepafloxacin; trovafloxacin; ofloxacin; norfloxacin; nalidixic acid; lomefloxacin; gatifloxacin; levofloxacin; sparfloxacin; antibiotic target alteration; enoxacin; ciprofloxacin; pefloxacin; fluoroquinolone antibiotic; moxifloxacin; ARO_description "UPDATED ARO_description with Point mutation in Staphylococcus aureus parE resulting in fluoroquinolones resistance. " 334 UPDATE mexX erythromycin; arbekacin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; model_sequences; ARO_category "UPDATED accession with AB015853.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3266 UPDATE CAM-1 penam; carbapenem; imipenem; cephalosporin; piperacillin-tazobactam; doripenem; cefotaxime; ceftazidime; antibiotic inactivation; cephamycin; CAM beta-lactamase; piperacillin; tazobactam; ceftolozane; cefoxitin; meropenem; ARO_description; ARO_category "UPDATED ARO_description with CAM-1 is a CAM (Central Alberta Metallo) beta-lactamase and carbapenemase identified from 4 clinical isolates of Pseudomonas aeruginosa from a Canadian hospital. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with A fifth generation cephalosporin antibiotic. " 5003 UPDATE OXA-691 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 330 UPDATE IMP-26 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-26 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with GU045307.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 333 UPDATE CARB-23 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Present in Lahey's list of beta-lactamases, not yet released. UPDATED accession with CP007005.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 332 UPDATE R39 penam; R39 beta-lactamase; antibiotic inactivation; ARO_description; model_sequences; model_name; ARO_category "UPDATED ARO_description with Class A beta-lactamase found in Actinomadura R39. UPDATED accession with X53650.1 UPDATED model_name with R39 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4101 UPDATE KPC-36 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-36 [Klebsiella pneumoniae] Accession: WP_114699267.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3269 UPDATE Clostridioides difficile rpoB with mutation conferring resistance to rifampicin antibiotic target alteration; antibiotic target replacement; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifamycin antibiotic; ARO_description "UPDATED ARO_description with Point mutations in the rpoB region of Clostridioides difficile which confer resistance to rifampin and rifampicin antibiotics. " 4625 UPDATE GES-42 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4102 UPDATE KPC-37 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-37 [Klebsiella pneumoniae] Accession: WP_116786832.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4105 UPDATE KPC-40 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-40 [Enterobacter hormaechei] Accession: WP_115470049.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4104 UPDATE KPC-39 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-39 [Klebsiella pneumoniae] Accession: WP_128268237.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4107 UPDATE KPC-42 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-42 [Klebsiella pneumoniae] Accession: WP_136512070.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4106 UPDATE KPC-41 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-41 [Klebsiella pneumoniae] Accession: WP_148044419.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4109 UPDATE KPC-45 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-45 [Enterobacter cloacae] Accession: WP_148044420.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4108 UPDATE KPC-43 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Carbapenem-hydrolyzing class A beta-lactamase kpc-43 [Klebsiella pneumoniae] Accession: WP_136512071.1. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5126 UPDATE OXA-823 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1295 UPDATE catII antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with catII is a plasmid-encoded variant of the cat gene found in Haemophilus influenzae, Agrobacterium tumefaciens and Escherichia coli. UPDATED accession with X53797.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 5178 UPDATE OXA-881 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3967 UPDATE ADC-182 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with ADC ortholog described by Nodari et al. 2020. " 5127 UPDATE OXA-824 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5002 UPDATE OXA-690 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2127 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to kanamycin kanamycin A; antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to kanamycin. " 1901 UPDATE CTX-M-51 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with DQ211987.1 " 3898 UPDATE CMY-156 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_056410.1 " 3899 UPDATE CMY-160 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_057614.1 " 1634 UPDATE CMY-78 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ733575.1 " 3892 UPDATE CMY-107 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_048777.1 " 3890 UPDATE CMY-134 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KP860987.1 " 3891 UPDATE CMY-143 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_052047.1 " 3896 UPDATE CMY-147 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_052898.1 " 3897 UPDATE CMY-146 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_052648.1 " 3894 UPDATE CMY-173 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with NG_070783.1 " 1468 UPDATE SHV-135 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ637576.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3467 UPDATE OXA-305 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3466 UPDATE OXA-304 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5001 UPDATE OXA-689 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5133 UPDATE OXA-831 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3465 UPDATE OXA-303 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3464 UPDATE OXA-302 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1085 UPDATE OKP-B-5 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-5 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAAGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACACCGCCGGCAATCTGCTGTTGAAGATCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGCTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTTGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGTGATACCCCGGCGACCATGGTCGAGCGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 885 UPDATED accession with AM850918.2 UPDATED fmin with 24 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12356.2 UPDATED sequence with MRYVRLCLISLIAALPLAVFASPQPLEQIKISESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNTAGNLLLKIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTPATMVERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1464 UPDATE aadA7 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with aadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica. UPDATED accession with AB114632.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 3463 UPDATE OXA-301 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3631 UPDATE Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam penam; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; cephamycin; ceftriaxone; model_sequences; model_name; ARO_category "UPDATED accession with LR134358.1 UPDATED model_name with Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. " 1496 UPDATE OXA-224 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-224 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGAAAAACACAATACATATCAACTTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGTATCCACAAACACTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGAGAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTAAACACACTAAATTTATAA UPDATED fmax with 3111 UPDATED accession with JN596991.2 UPDATED fmin with 2280 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AEQ73521.1 UPDATED sequence with MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDVSTNTEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2119 UPDATE LRA-10 penam; antibiotic inactivation; cephalosporin; class C LRA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with LRA-10 is a beta-lactamase isolated from soil samples in Alaska. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3462 UPDATE OXA-300 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1353 UPDATE GES-5 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-5 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY494717.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1466 UPDATE SHV-13 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF164577.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4079 UPDATE DfrA37 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED accession with NG_070720.1 " 4078 UPDATE DfrA34 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED accession with NG_062229.1 " 5000 UPDATE OXA-688 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4075 UPDATE OXA-499 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_049775.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4074 UPDATE OXA-653 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_057615.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4077 UPDATE Trimethoprim-resistant dihydrofolate reductase DfrA43 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; model_sequences "UPDATED accession with NG_070721.1 " 4076 UPDATE OXA-825 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_065436.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4071 UPDATE OXA-646 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_065432.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4070 UPDATE OXA-648 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_065434.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4073 UPDATE OXA-897 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_068017.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4072 UPDATE OXA-649 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with NG_057485.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3966 UPDATE ADC-181 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with ADC ortholog described by Nodari et al. 2020. " 841 UPDATE CTX-M-14 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-14 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED partial with 0 UPDATED sequence with ATGGTGACAAAGAGAGTGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTGCTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCGCAGATAATACGCAGGTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCCGCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATCAAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATGACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAATTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGATGAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCGAGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCATGCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGCGCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGTGGGTGATAAGACCGGCAGCGGCGACTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTGGTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTGGCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA UPDATED fmax with 2616 UPDATED accession with AF252622.2 UPDATED fmin with 1740 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAF72530.1 UPDATED sequence with MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL " 3964 UPDATE SHV-209 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3965 UPDATE SHV-215 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3962 UPDATE SHV-224 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3963 UPDATE SHV-225 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1910 UPDATE CTX-M-136 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with KC351754.1 " 3961 UPDATE SHV-193 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 08-JUN-2016. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1497 UPDATE dfrA10 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA10 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGAATATATCACTTATCTTTGCCAATGAATTAATTACCAGAGCATTCGGTAATCAAGGCAAATTACCTTGGCAATTCATTAAAGAAGATATGCAGTTCTTCCAGAAGACTACAGAAAATTCTGTAGTCGTTATGGGATTAAATACATGGAGATCTCTACCTAAGATGAAGAAGCTTGGTAGAGACTTCATTGTCATATCTTCAACTATCACAGAGCACGAAGTGCTCAACAATAATATCCAAATATTCAAATCATTTGAGAGCTTCTTAGAAGCATTCAGAGACACAACCAAACCAATCAATGTCATTGGTGGTGTTGGTTTATTATCTGAAGCGATAGAACATGCTAGCACTGTTTACATGAGTTCTATTCATATGGTTAAACCTGTTCATGCTGATGTGTATGTACCGGTAGAACTAATGAATAAACTCTATAGTGATTTCAAATATCCAGAAAATATTCTATGGGTAGGTGATCCAATAGATTCTGTGTATAGCTTGTCTATTGATAAGTTTGTTAGACCAGCTTCGCTGGTTGGGGTGCCAAATGATATTAATACGTGA UPDATED fmax with 112122 UPDATED accession with KF976462.2 UPDATED fmin with 111558 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AHG97174.1 UPDATED sequence with MNISLIFANELITRAFGNQGKLPWQFIKEDMQFFQKTTENSVVVMGLNTWRSLPKMKKLGRDFIVISSTITEHEVLNNNIQIFKSFESFLEAFRDTTKPINVIGGVGLLSEAIEHASTVYMSSIHMVKPVHADVYVPVELMNKLYSDFKYPENILWVGDPIDSVYSLSIDKFVRPASLVGVPNDINT " 1462 UPDATE LRA-19 penam; antibiotic inactivation; subclass B3 LRA beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LRA-19 is a beta-lactamase isolated from soil samples in Alaska. UPDATED accession with EU408359.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1962 UPDATE OXA-47 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-47 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY237830.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3371 UPDATE FosB5 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; ARO_description "UPDATED ARO_description with Fosfomycin resistance gene. High homology with FosB1 and FosB3. " 3968 UPDATE ADC-183 antibiotic inactivation; cephalosporin; ADC beta-lactamase without carbapenemase activity; ARO_description "UPDATED ARO_description with ADC ortholog described by Nodari et al. 2020. " 3969 UPDATE SHV-228 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2854 UPDATE PDC-75 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. " 1101 UPDATE CTX-M-21 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-21 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AJ416346.1 " 3638 UPDATE LEN-39 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Klebsiella variicola subsp. tropica UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3639 UPDATE LEN-40 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Klebsiella variicola subsp. tropica UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3636 UPDATE LEN-34 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with A class-A beta-lactamase from Klebsiella variicola. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3637 UPDATE LEN-38 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with A class-A beta-lactamase from Klebsiella. UPDATED NCBI_taxonomy_name with Klebsiella variicola subsp. tropica UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3634 UPDATE LEN-30 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with A class-A beta-lactamase from Klebsiella pneumoniae. UPDATED accession with SLY33602.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3635 UPDATE LEN-32 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with A class-A beta-lactamase from Klebsiella variicola. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3633 UPDATE OXA-724 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with An OXA-12-family class D beta-lactamase identified from Aeromonas hydrophila. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 840 UPDATE CMY-20 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-20 is a beta-lactamase found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCCGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGTTTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAACAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTCCAATAA UPDATED fmax with 1143 UPDATED accession with AY960293.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAX58682.2 UPDATED sequence with MKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ " 1400 UPDATE CTX-M-74 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-74 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with GQ149243.1 " 4611 UPDATE GES-28 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 3506 UPDATE OXA-433 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4610 UPDATE GES-27 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 3468 UPDATE OXA-306 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4613 UPDATE GES-30 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4612 UPDATE GES-29 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4615 UPDATE GES-32 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4614 UPDATE GES-31 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1649 UPDATE DHA-21 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087847.1 " 4617 UPDATE GES-34 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 4616 UPDATE GES-33 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 5005 UPDATE OXA-693 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3372 UPDATE FosB6 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; ARO_description "UPDATED ARO_description with Fosfomycin resistance gene. High homology with FosB1 and FosB3. " 1169 UPDATE OXA-360 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF421163.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3336 UPDATE qnrE2 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_category "UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3669 UPDATE NDM-28 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A class B New Delhi metallo-beta-lactamase and NDM-1 variant. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1889 UPDATE NDM-4 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; ticarcillin; NDM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with NDM-4 is a beta-lactamase found in Escherichia coli. UPDATED accession with JQ348841.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1888 UPDATE MIR-10 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087858.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 1887 UPDATE TEM-70 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF188199.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3701 UPDATE Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides antibiotic target alteration; sulfonamide resistant dihydropteroate synthase folP; sulfonamide antibiotic; model_sequences; ARO_category "UPDATED accession with WHPL01000002.1 UPDATED category_aro_description with Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. " 4462 UPDATE CMA-2 antibiotic inactivation; cephalosporin; CMA beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4463 UPDATE CME-2 penam; antibiotic inactivation; CME beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4461 UPDATE CMA-1 antibiotic inactivation; cephalosporin; CMA beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 2121 UPDATE LRA-7 penam; antibiotic inactivation; subclass B3 LRA beta-lactamase; cephalosporin; ARO_description; ARO_category "UPDATED ARO_description with LRA-7 is a beta-lactamase isolated from soil samples in Alaska. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2123 UPDATE vgaC dalfopristin; pleuromutilin; virginiamycin M1; pleuromutilin antibiotic; madumycin II; griseoviridin; ABC-F ATP-binding cassette ribosomal protection protein; macrolide antibiotic; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 948 UPDATE mecI penam; methicillin resistant PBP2; methicillin; antibiotic target replacement; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 949 UPDATE CTX-M-77 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with AM982521.1 " 2128 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to gentamicin antibiotic target alteration; gentamicin C; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description "UPDATED ARO_description with Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to gentamicin. " 944 UPDATE bcrB peptide antibiotic; ATP-binding cassette (ABC) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; bacitracin B; bacitracin F; bacitracin A; ARO_description; model_sequences "UPDATED ARO_description with bcrB is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. UPDATED accession with L20573.1 " 1084 UPDATE LEN-5 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-5 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY633109.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 942 UPDATE OXA-104 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-104 is a beta-lactamase found in A. baumannii. UPDATED accession with EF581285.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4913 UPDATE OXA-587 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4662 UPDATE GOB-50 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 941 UPDATE GES-1 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-1 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AF156486.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 1356 UPDATE dfrA22 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with dfrA22 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. " 1594 UPDATE vgbA virginiamycin S2; pristinamycin IB; quinupristin; pristinamycin IC; patricin B; patricin A; ostreogrycin B3; vernamycin C; pristinamycin IA; antibiotic inactivation; streptogramin antibiotic; streptogramin vgb lyase; model_sequences; model_name; ARO_category "UPDATED accession with M20129.1 UPDATED model_name with vgbA UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 5173 UPDATE OXA-876 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5172 UPDATE OXA-875 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5171 UPDATE OXA-874 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5170 UPDATE OXA-873 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5177 UPDATE OXA-880 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5176 UPDATE OXA-879 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5175 UPDATE OXA-878 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5174 UPDATE OXA-877 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5179 UPDATE OXA-882 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1535 UPDATE CMY-16 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-16 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with AJ781421.1 " 2656 UPDATE Escherichia coli emrE efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; small multidrug resistance (SMR) antibiotic efflux pump; macrolide antibiotic; erythromycin; ARO_description "UPDATED ARO_description with Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation. " 3416 UPDATE OXA-152 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3417 UPDATE OXA-153 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 131 UPDATE CTX-M-50 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-50 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY847146.1 " 130 UPDATE CTX-M-112 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JF274246.1 " 3412 UPDATE OXA-126 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 136 UPDATE CMY-9 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-9 is a beta-lactamase found in Escherichia coli. UPDATED accession with AB061794.1 " 135 UPDATE SME-5 carbapenem; antibiotic inactivation; SME beta-lactamase; model_sequences "UPDATED accession with KJ188748.1 " 134 UPDATE rgt1438 antibiotic inactivation; rifampin; rifapentine; rifampin glycosyltransferase; rifabutin; rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with rgt1438 is a glycosyltransferase that confers rifampin resistance in Streptomyces. UPDATED NCBI_taxonomy_name with Streptomyces sp. WAC 01438 " 5185 UPDATE OXA-888 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 139 UPDATE QnrB10 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB10 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with DQ631414.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 138 UPDATE Streptomyces lividans cmlR antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; model_name "UPDATED ARO_description with cmlR is a plasmid or chromosome-encoded chloramphenicol resistance determinant (putative transmembrane protein) that is found in Escherichia coli and Streptomyces lividans. UPDATED accession with X59968.1 UPDATED model_name with Streptomyces lividans cmlR " 5156 UPDATE OXA-859 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3418 UPDATE OXA-154 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3419 UPDATE OXA-155 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 410 UPDATE AAC(3)-IIIb kanamycin A; antibiotic inactivation; AAC(3); aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(3)-IIIb is an aminoglycoside acetyltransferase in P. aeruginosa. " 4868 UPDATE OXA-533 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4869 UPDATE OXA-534 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2019 UPDATE OXA-213 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JN861781.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2018 UPDATE CMY-76 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JQ733573.1 " 1930 UPDATE CTX-M-29 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-29 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY267213.1 " 2015 UPDATE DHA-3 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with DHA-3 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AY494945.1 " 2014 UPDATE PmrF pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; model_sequences; model_name "UPDATED accession with U00096.1 UPDATED model_name with PmrF " 2017 UPDATE CTX-M-37 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-37 is a beta-lactamase found in Salmonella enterica. UPDATED partial with 0 UPDATED sequence with ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGCATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCAGCAGTCGGGAGGAAGGCTGGGTGTGGCATTGATTAACACAGCGGATAATTCGCAAATACTTTATCGTGCAGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTGGTTAACTATAATCCGATTGCGGAAAAGCACGTCGATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGCACCGAGCCGACGTTAAACACAGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACGCTGCGTAATCTGACGCTGGGTAAAGCATTGGGTGACAGCCAACGGGCGCAGCTGGTGACGTGGATGAAAGGCAATACTACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGACTATGGTACCACCAACGATATCGCGGTGATTTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCCCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAG UPDATED fmax with 2516 UPDATED accession with AY649755.2 UPDATED fmin with 1640 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterobacter cloacae UPDATED NCBI_taxonomy_id with 550 UPDATED NCBI_taxonomy_cvterm_id with 36884 UPDATED accession with AAT70415.1 UPDATED sequence with MVKKSLRQFTLMATATVTLLLGSVPLHAQTADVQQKLAELEQQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL " 2016 UPDATE OXA-370 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-370 is a beta-lactamase found in Enterobacter hormaechei. UPDATED accession with KF900153.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2011 UPDATE QnrB60 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB60 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with AB734055.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 2010 UPDATE CTX-M-129 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JX017364.1 " 2013 UPDATE Erm(41) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED partial with 1 UPDATED sequence with GTGGATCTGGGCGCAGGACACGGCGCGCTGACGGCACATCTGGTTGCCGCTGGCGCCAGGGTGCTAGCCGTCGAGCTGCATCCGGGGCGGGCTCGACACCTTCGTTCACGGTTTGCCGAGGAAGATGTCCGGGTAGCGGAAGCGGACCTACTCGCCTTCCGGTGGCCGCGACGGCCATTTCGGGTGGTGGCGAGCCCGCCCTACCAAGTCACCAGCGCACTGATCCGGAGTCTCTTGACGCCGGAATCCCGGCTGCTGGCTGCCGACCTGGTGCTGCAGCGCGGGGCTGTGCACAAACATGCGAAGCGAGCACCTGTTCGCCATTGGACGCTACGGGCCGGAATCACATTGCCGCGAAGCGCTTTCCATCATCCACCGCAGGTGGATTCGTCGGTGCTGGTGATCAGGCGGCGCTGACCCTGTGACAGACTGCGGGCATGTTGCGTATCGGCCTAACCGGTGGAATCGGTGCGGGGAAGTCCACCGTCTCGCGGACCCTCGCCGGGTGCGGGGCTTTCATCGTGGACAGCGATGTGATCGCACGCGAGGTGGTGGAACCCGGAACGCCTGGGCTGGCGGCGCTCGTGGAGGCCTTTG UPDATED fmax with 3649 UPDATED accession with EU177504.3 UPDATED fmin with 3052 UPDATED strand with + UPDATED NCBI_taxonomy_name with Mycobacteroides abscessus UPDATED NCBI_taxonomy_id with 36809 UPDATED NCBI_taxonomy_cvterm_id with 36888 UPDATED accession with ABW06859.1 UPDATED sequence with MDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSRFAEEDVRVAEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHPPQVDSSVLVIRRR UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 2012 UPDATE SHV-178 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF705209.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5160 UPDATE OXA-863 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1937 UPDATE OXA-118 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-118 is a beta-lactamase found in Burkholderia cepacia. UPDATED accession with AF371964.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2129 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin " 3560 UPDATE BES-1 penam; antibiotic inactivation; BES Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3566 UPDATE BRO-2 penam; antibiotic inactivation; BRO Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3567 UPDATE CBP-1 penam; CBP beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3564 UPDATE BPU-1 penam; antibiotic inactivation; BPU Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3565 UPDATE BRO-1 penam; antibiotic inactivation; BRO Beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3568 UPDATE CGA-1 penam; antibiotic inactivation; CGA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 511 UPDATE dfrA3 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli. UPDATED accession with J03306.1 " 4484 UPDATE CRP-1 carbapenem; antibiotic inactivation; CRP beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1936 UPDATE CTX-M-43 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with DQ102702.1 " 4487 UPDATE CSP-1 antibiotic inactivation; cephalosporin; CSP beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4481 UPDATE CRH-1 carbapenem; antibiotic inactivation; CRH beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4482 UPDATE CRH-2 carbapenem; antibiotic inactivation; CRH beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 2900 UPDATE EBR-2 carbapenem; penam; cephalosporin; EBR beta-lactamase; antibiotic inactivation; ARO_description; ARO_category "UPDATED ARO_description with EBR-2 is a novel EBR-like class B beta-lactamase isolated from an extensively drug-resistant strain of Empedobacter falsenii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 709 UPDATE TEM-213 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF663615.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 147 UPDATE OXA-27 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-27 is a beta-lactamase found in A. baumannii. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4892 UPDATE OXA-563 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 705 UPDATE CMY-116 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM087840.1 " 706 UPDATE APH(7'')-Ia antibiotic inactivation; APH(7''); hygromycin B; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(7'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. hygroscopicus. UPDATED accession with X03615.1 UPDATED category_aro_description with Phosphorylation of hygromycin on the hydroxyl group at position 7''. " 707 UPDATE AIM-1 penam; AIM beta-lactamase; cephalosporin; antibiotic inactivation; cephamycin; model_sequences; ARO_category "UPDATED accession with AM998375.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 700 UPDATE ACT-31 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KM087843.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 701 UPDATE SHV-129 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with GU827715.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3260 UPDATE dfrA30 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with A dihydrofolate reductase and trimethoprim resistance gene from Klebsiella pneumoniae. " 703 UPDATE cmlv antibiotic inactivation; chloramphenicol phosphotransferase; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae. UPDATED accession with U09991.1 " 609 UPDATE emrK tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with D78168.1 " 89 UPDATE vanYA glycopeptide resistance gene cluster; teicoplanin; vanY; glycopeptide antibiotic; antibiotic target alteration; vancomycin; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanYA, is a vanY variant found in the vanA gene cluster. UPDATED accession with M97297.1 UPDATED model_name with vanY gene in vanA cluster UPDATED ARO_name with vanY gene in vanA cluster " 4940 UPDATE OXA-614 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 82 UPDATE PER-4 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; PER beta-lactamase; monobactam; model_sequences; ARO_category "UPDATED accession with EU748544.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 80 UPDATE ACT-29 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KM087832.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 81 UPDATE FOX-3 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with FOX-3 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with Y11068.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 86 UPDATE TEM-102 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY040093.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 87 UPDATE TEM-116 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 84 UPDATE GIM-1 penam; GIM beta-lactamase; penem; carbapenem; cephalosporin; antibiotic inactivation; cephamycin; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GIM-1 is an integron-encoded B1 beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AJ620678.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 85 UPDATE IMP-42 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with AB753456.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 796 UPDATE iri antibiotic inactivation; rifampin monooxygenase; rifampin; rifapentine; rifabutin; rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with iri is a monooxygenase that confers resistance to rifampin found in Rhodococcus hoagii. UPDATED accession with U56415.1 " 762 UPDATE CTX-M-55 antibiotic inactivation; ceftazidime; ceftriaxone; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-55 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with DQ885477.1 " 141 UPDATE vanRB glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRB, is a vanR variant found in the vanB gene cluster. UPDATED accession with U35369.1 UPDATED model_name with vanR gene in vanB cluster UPDATED ARO_name with vanR gene in vanB cluster " 1658 UPDATE OKP-B-4 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-4 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051153.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1659 UPDATE OXA-258 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGACAGTTCGACTCGTTTCGCGCGCCCTGGGCGCAGTCCTCTTTGCGTCCGCCCTGACCCTGCCCGCCCGGGCGGACGTCCTGTGCACCCTGGTGGCCGACGCCGCCGACGGCCGCATCCTGTTCCAGCAGGGCACGCGGCAGGACTGCACGCAGCGCTACACCCCCGCCTCGACCTTCAAGCTGCCCATCGCCCTGATGGGCGCGGATGCCGGCATCCTGCAGGGCCCGCACCAGCCCGTCTGGAACTACCAGCCCGCTTATCCCGACTGGGGCGGCGAGGCCTGGCGCCAGCCCACCGATCCGGCTCGCTGGATCAAGTATTCGGTGGTCTGGTACTCGCAGTTGACCGCCAGGGCGCTGGGGCAGGAGCGCTTCCAGCGCTACACCTCCGCGTTCGGTTATGGCAACGCGGACGTCTCGGGTGAACCCGGCAAGCACAACGGCACCGATGGCGCGTGGATCATCTCCTCGCTGCGCATTTCGCCGTTTGAGCAGGTGGACTTCCTGCGCAAGTTCGTCAACCGGCAACTGCCCGTCAAGGCGGCTGCCTATGACCTGGCCGAGAACCTGTTCGAGGTCGGCGAAGCCGACGGCTGGCGTCTGTACGGCAAGACCGGAACCGGCTCGCCCGGCAGCCACGGCGTCTACACGCCGGCCAACGCCTATGGCTGGTTCGTCGGCTGGGCGCGCAAGGACGACCGCCAACTGGTGTTTGCCCGCCTGCTGCAGGACGAGGGGGCGACCCAGCCCAATGCCGGCCTGCGCGCCCGCGACGGCCTGATGCGCGACTGGGCCGCCATGGTCGCGGCGCCCCGCAAATGA UPDATED fmax with 825 UPDATED accession with HE614014.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Achromobacter ruhlandii UPDATED NCBI_taxonomy_id with 72557 UPDATED NCBI_taxonomy_cvterm_id with 39091 UPDATED accession with CCE73593.2 UPDATED sequence with MTVRLVSRALGAVLFASALTLPARADVLCTLVADAADGRILFQQGTRQDCTQRYTPASTFKLPIALMGADAGILQGPHQPVWNYQPAYPDWGGEAWRQPTDPARWIKYSVVWYSQLTARALGQERFQRYTSAFGYGNADVSGEPGKHNGTDGAWIISSLRISPFEQVDFLRKFVNRQLPVKAAAYDLAENLFEVGEADGWRLYGKTGTGSPGSHGVYTPANAYGWFVGWARKDDRQLVFARLLQDEGATQPNAGLRARDGLMRDWAAMVAAPRK UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1652 UPDATE IMP-20 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with AB196988.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1653 UPDATE AAC(6')-Ip AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(6')-Ip is an aminoglycoside acetyltransferase encoded by plasmids and integrons in C. freundii, E. coli, E. faecium and Klebsiella aerogenes. " 1650 UPDATE CMY-15 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-15 is a beta-lactamase found in Proteus mirabilis. UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAACTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA UPDATED fmax with 1146 UPDATED accession with AJ555823.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Proteus mirabilis UPDATED NCBI_taxonomy_id with 584 UPDATED NCBI_taxonomy_cvterm_id with 36771 UPDATED accession with CAD88477.1 UPDATED sequence with MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ " 1651 UPDATE AAC(6')-If AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-If is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. UPDATED accession with X55353.1 " 1656 UPDATE CTX-M-79 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-79 is a beta-lactamase found in Escherichia coli. UPDATED accession with EF426798.1 " 1657 UPDATE AAC(6')-IIa AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica. UPDATED accession with AY123251.1 " 1654 UPDATE SHV-95 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF373972.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1655 UPDATE TEM-117 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY130282.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 586 UPDATE VIM-20 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with GQ414736.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5238 UPDATE OXY-2-15 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 584 UPDATE aadA21 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; model_sequences; ARO_category "UPDATED accession with AY171244.1 UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 585 UPDATE NDM-7 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with NDM-7 is a beta-lactamase found in Escherichia coli. UPDATED accession with JX262694.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 763 UPDATE catI antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with catI is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii. UPDATED accession with V00622.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 583 UPDATE SHV-100 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM941846.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 580 UPDATE TEM-110 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY072920.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1984 UPDATE SHV-144 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JQ926986.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 588 UPDATE OKP-A-7 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-7 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051146.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 589 UPDATE TEM-145 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCAGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTATGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCACGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAAGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA UPDATED fmax with 861 UPDATED accession with DQ105528.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAZ14083.2 UPDATED sequence with MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLMRSALPAGWFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1985 UPDATE SHV-7 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with U20270.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5004 UPDATE OXA-692 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2839 UPDATE GOB-18 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2838 UPDATE MCR-1.2 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with A plasmid-borne novel MCR-1 functional variant detected in a Klebsiella pneumoniae isolate collected from a rectal swab in Italy. MCR-1.2 differs from MCR-1 by a single amino acid substitution from Glutamine to Leucine at position 3 in the N-terminal region. Described by DiPilato et al. 2016. " 2837 UPDATE APH(2'')-If antibiotic inactivation; kanamycin A; aminoglycoside antibiotic; gentamicin B; isepamicin; sisomicin; arbekacin; APH(2''); netilmicin; gentamicin C; amikacin; dibekacin; gentamicin A; tobramycin; ARO_category "UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''. " 2836 UPDATE Bla2 carbapenem; penam; cephalosporin; antibiotic inactivation; subclass B1 Bacillus anthracis Bla beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY453162.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2835 UPDATE PatA-PatB antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; ciprofloxacin; fluoroquinolone antibiotic; model_description "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). " 2834 UPDATE Mycobacterium tuberculosis iniB with mutation conferring resistance to ethambutol antibiotic efflux; polyamine antibiotic; Ethambutol resistant iniB; efflux pump complex or subunit conferring antibiotic resistance; ethambutol; antibiotic target alteration; ARO_category "UPDATED category_aro_description with Point mutations occurring in the iniB region of the iniBAC operon shown to confer resistance to ethambutol. " 2833 UPDATE Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; tylosin; ARO_description "UPDATED ARO_description with Point mutation in B. hyodysenteriae 23S rRNA shown to confer resistance to tylosin and erythromycin. " 2832 UPDATE AAC(2')-Ie antibiotic inactivation; AAC(2'); arbekacin; gentamicin B; gentamicin C; amikacin; aminoglycoside antibiotic; tobramycin; ARO_description "UPDATED ARO_description with AAC(2')-Ie is a chromosomal-encoded aminoglycoside acetyltransferase in M. leprae. " 2831 UPDATE rpoB2 rifampin; rifapentine; rifabutin; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); antibiotic target replacement; antibiotic target alteration; rifaximin; rifamycin antibiotic; model_name "UPDATED model_name with rpoB2 " 1635 UPDATE vanRG glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRG, is a vanR variant found in the vanG gene cluster. UPDATED accession with DQ212986.1 UPDATED model_name with vanR gene in vanG cluster UPDATED ARO_name with vanR gene in vanG cluster " 1434 UPDATE Erm(35) antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 1435 UPDATE cmlA6 antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmlA6 is a plasmid-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa. UPDATED accession with AF294653.1 " 3399 UPDATE aadA8b antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_description; ARO_category "UPDATED ARO_description with aadA8b is an aminoglycoside nucleotidyltransferase gene encoded by plasmids in E. coli; can be created by a recombination event between aadA1 and aadA2. UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 3398 UPDATE aadA10 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. " 1637 UPDATE MOX-7 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; model_sequences; ARO_category "UPDATED accession with GQ152602.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1260 UPDATE APH(3')-IVa antibiotic inactivation; aminoglycoside antibiotic; paromomycin; kanamycin A; APH(3'); gentamicin B; ribostamycin; G418; neomycin; butirosin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in Niallia circulans. UPDATED accession with X03364.1 UPDATED NCBI_taxonomy_name with Niallia circulans UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 5230 UPDATE OXA-946 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5231 UPDATE OXA-947 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1349 UPDATE IND-2a carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-2a is a beta-lactamase found in Chryseobacterium indologenes. UPDATED accession with AF219130.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 5232 UPDATE OXA-948 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1541 UPDATE ACT-14 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with JX440354.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5233 UPDATE OXA-949 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 451 UPDATE LRA-5 class A LRA beta-lactamase; penam; cephalosporin; antibiotic inactivation; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LRA-5 is a beta-lactamase isolated from soil samples in Alaska. UPDATED accession with EU408358.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 452 UPDATE QnrVC4 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrVC4 is an integron-mediated quinolone resistance protein found in Aeromonas punctata. UPDATED accession with GQ891757.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 453 UPDATE mtrE penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; penicillin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with X95635.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 454 UPDATE KPC-4 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with KPC-4 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 456 UPDATE adeR antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; tetracycline antibiotic; tetracycline; model_sequences "UPDATED accession with HM440348.1 " 5235 UPDATE OXY-2-12 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 318 UPDATE OXA-358 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF421161.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5236 UPDATE OXY-2-13 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1886 UPDATE LEN-24 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-24 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGTGTTATCTCCCTGTTAGCCAACCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACATATCGCCGGGATCGGCGCAGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 891 UPDATED accession with AM850914.2 UPDATED fmin with 30 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12352.2 UPDATED sequence with MRYVRLCVISLLANLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 564 UPDATE IMP-22 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAAGAAATTATTTGTTTTATGTGTGTTTTTGTTTTGTAGCATTACTGCCGCAGGAGAGTCTTTGCCCGATTTAAAAATTGAAAAGCTTGAAGAAGGTGTTTATGTTCATACATCGTTTGAAGAAGTTAATGGTTGGGGCGTTGTTTCTAAACACGGTTTGGTTATTCTTGTGAATACTGACGCCTATCTGATTGACACTCCATTCACGGCTAAAGATACTGAAAAGTTAGTCACCTGGTTTGTGGAGCGCGGCTATAAAATCAAAGGTAGCATTTCCTCACATTTCCATAGCGACAGCACGGGTGGAATAGAGTGGCTTAATTCTCAATCAATTCCCACGTATGCATCTGAATTAACAAATGACCTTCTTAAACAAAACGGTAAGGTACAAGCTAAAAACTCATTTAGCGGAGTTAGTTATTGGTTAGTTAAAAATAAAATTGAAGTTTTCTATCCCGGCCCCGGGCACACTCAAGATAACGTAGTGGTTTGGTTGCCTGAAAAGAAAATTTTATTTGGTGGGTGCTTTGTTAAACCGTACGGTCTTGGAAATCTCGATGACGCAAATGTTGTAGCATGGCCACATTCTGCTGAAATATTAATGTCTAGGTATGGTAATGCAAAACTGGTTGTTCCAAGCCATAGTGACATCGGAGATGCGTCGCTCTTGAAGCTTACATGGGAGCAGGCTGTTAAAGGGCTAAAAGAAAGTAAAAAACCATCAGAGCCAAGTAACTAA UPDATED fmax with 1097 UPDATED accession with DQ361087.2 UPDATED fmin with 356 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas fluorescens UPDATED NCBI_taxonomy_id with 294 UPDATED NCBI_taxonomy_cvterm_id with 36937 UPDATED accession with ABC88434.1 UPDATED sequence with MKKLFVLCVFLFCSITAAGESLPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVILVNTDAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNDLLKQNGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPYGLGNLDDANVVAWPHSAEILMSRYGNAKLVVPSHSDIGDASLLKLTWEQAVKGLKESKKPSEPSN UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5237 UPDATE OXY-2-14 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 517 UPDATE QnrD2 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrD2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. UPDATED accession with KJ158441.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3263 UPDATE dfrA32 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with A dihydrofolate reductase and trimethoprim resistance gene identified from non-typhoidal multidrug-resistant Salmonella enterica. " 3259 UPDATE dfrA28 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with A dihydrofolate reductase and trimethoprim resistance gene from Aeromonas hydrophilia. " 832 UPDATE SHV-161 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121128.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1502 UPDATE OXA-209 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with OXA-209 is a beta-lactamase found in Riemerella anatipestifer. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1503 UPDATE LEN-4 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LEN-4 is a beta-lactamase found in Escherichia coli. UPDATED accession with AY130287.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1500 UPDATE APH(6)-Ia antibiotic inactivation; APH(6); streptomycin; aminoglycoside antibiotic; plazomicin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(6)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. UPDATED accession with Y00459.1 UPDATED category_aro_description with Phosphorylation of streptomycin on the hydroxyl group at position 6. " 1501 UPDATE CMY-49 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with GQ402541.1 " 1506 UPDATE ACT-12 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with JX440355.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1507 UPDATE smeA penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; aminoglycoside antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with smeA is the membrane fusion protein of the smeABC multidrug efflux complex in Stenotrophomonas maltophilia. UPDATED accession with AF173226.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1504 UPDATE CMY-108 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KF564648.1 " 651 UPDATE Staphylococcus aureus mprF peptide antibiotic; antibiotic target alteration; defensin resistant mprF; defensin; model_sequences "UPDATED accession with HM140977.1 " 1508 UPDATE QnrA2 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrA2 is a plasmid-mediated quinolone resistance protein found in Klebsiella oxytoca. UPDATED accession with HQ449669.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1509 UPDATE vanXF glycopeptide antibiotic; glycopeptide resistance gene cluster; vanX; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXF, is a vanX variant found in the vanF gene cluster. UPDATED partial with 0 UPDATED sequence with ATGGAAAAAGATTTTGTTTTTTTAGATGAAATATTGCATGGAGTTCGTTGGGACTCCAAATATGCCACATGGGACAATTTCACTGGAAAACCGGTAGACGGATATGAAGTCAATCGCATAGCGGGGACATATGCTTTGGCTGTTGCGCTGCTGGAGGTAAAGAAGCAGGCGGCTGCTCTAGGGTACGGCTTGCTCCTGTGGGATGGCTATCGTCCTCAACGTGCGGTAAACTGTTTCTTGCATTGGTCTGCGCAGCCGGAAGACGGCCGCACAAAAGAAAGATATTATCCCAATATTGATCGGATCGAGATGGTTACAAAGGGATATGTGGCTTCAAAATCAAGCCACAGTCGCGGAAGCGCGATTGACCTTACGCTTTATCGATTGGACACGGGTGCGCTTGTCCCTATGGGGAGCGGCTTCGATTTTATGGATGAACGTTCACATCATACCTCAAAAGGAATTTCAAGTAACGAAGCGCAAAATCGCCAGTTATTATGTTCTATTATGGAATACAGCGGATTTGAATCATATGTATATGAATGGTGGCACTACGTATTAAGAAACGAACCATACCCCAGCAGCTATTTTGATTTTCCCATTGGCGGGAACCATCTAGACCCATTTTCCAACTTTTGTGGGACAGTGCCACTTGATGCGTTGTCGCCCTAA UPDATED fmax with 7648 UPDATED accession with AF155139.2 UPDATED fmin with 6976 UPDATED strand with + UPDATED NCBI_taxonomy_name with Paenibacillus popilliae ATCC 14706 UPDATED NCBI_taxonomy_id with 1212764 UPDATED NCBI_taxonomy_cvterm_id with 39542 UPDATED accession with AAF36804.1 UPDATED sequence with MEKDFVFLDEILHGVRWDSKYATWDNFTGKPVDGYEVNRIAGTYALAVALLEVKKQAAALGYGLLLWDGYRPQRAVNCFLHWSAQPEDGRTKERYYPNIDRIEMVTKGYVASKSSHSRGSAIDLTLYRLDTGALVPMGSGFDFMDERSHHTSKGISSNEAQNRQLLCSIMEYSGFESYVYEWWHYVLRNEPYPSSYFDFPIGGNHLDPFSNFCGTVPLDALSP UPDATED model_name with vanX gene in vanF cluster UPDATED ARO_name with vanX gene in vanF cluster " 3942 UPDATE CMY-138 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KT997883.1 " 658 UPDATE CMY-104 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KF150216.1 " 516 UPDATE eptA pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; model_sequences "UPDATED accession with AP009048.1 " 3943 UPDATE mcr-3.41 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with Novel mcr-3.41 gene identified in an Aeromonas veronii C198 isolate from a patient with Septicemia in Thailand by Hatrongjit et. al. " 3369 UPDATE FosB1 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; ARO_description "UPDATED ARO_description with Subtype of FosB, fosfomycin resistant. S.aureus SA1129 carried a FosB1 identical to S. haemolyticus. " 317 UPDATE TEM-148 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM087454.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1331 UPDATE CTX-M-52 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-52 is a beta-lactamase found in Escherichia coli. UPDATED accession with DQ223685.1 " 3945 UPDATE SHV-194 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 04-AUG-2016. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3767 UPDATE FRI-5 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3946 UPDATE SHV-220 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5684 UPDATE VEB-23 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 3947 UPDATE SHV-210 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Beta-lactamase gene from Klebsiella pneumoniae. Directed submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3885 UPDATE OXA-812 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3884 UPDATE OXA-818 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3883 UPDATE OXA-668 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4862 UPDATE OXA-527 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1247 UPDATE CMY-72 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JX440352.1 " 2126 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to tobramycin antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; tobramycin; ARO_description "UPDATED ARO_description with Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to tobramycin. " 3888 UPDATE Tet(X1) tetracycline antibiotic; antibiotic inactivation; tetracycline inactivation enzyme; model_sequences "UPDATED accession with AJ311171.1 " 946 UPDATE QnrB48 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB48 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JQ762640.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4917 UPDATE OXA-591 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4935 UPDATE OXA-609 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4914 UPDATE OXA-588 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1884 UPDATE CTX-M-111 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JF274243.1 " 568 UPDATE CTX-M-20 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-20 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AJ416344.1 " 4915 UPDATE OXA-589 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4863 UPDATE OXA-528 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 752 UPDATE vanRM glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanRM, is a vanR variant found in the vanM gene cluster. UPDATED accession with FJ349556.1 UPDATED model_name with vanR gene in vanM cluster UPDATED ARO_name with vanR gene in vanM cluster " 4660 UPDATE GOB-48 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 943 UPDATE vanUG glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanU; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanUG, is a vanG variant found in the vanG gene cluster. UPDATED accession with DQ212986.1 UPDATED model_name with vanU gene in vanG cluster UPDATED ARO_name with vanU gene in vanG cluster " 4910 UPDATE OXA-584 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4663 UPDATE GOB-51 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1883 UPDATE DHA-10 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KP050490.1 " 1519 UPDATE vatE dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with vatE is a transposon-mediated acetyltransferase found in Enterococcus faecium. UPDATED accession with AF242872.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 4008 UPDATE PDC-284 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-284 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4009 UPDATE PDC-105 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-105 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4860 UPDATE OXA-525 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1376 UPDATE MOX-6 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with MOX-6 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with GQ152601.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1460 UPDATE FosB3 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; model_sequences "UPDATED accession with HQ219726.1 " 4000 UPDATE TEM-237 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4001 UPDATE TEM-238 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4002 UPDATE TEM-240 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4003 UPDATE TEM-241 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4004 UPDATE TEM-242 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4005 UPDATE TEM-243 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4006 UPDATE PDC-225 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-225 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4007 UPDATE PDC-438 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-438 is class C beta-lactamase found in Pseudomonas aeruginosa. " 3971 UPDATE SHV-203 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 21-DEC-2017. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3970 UPDATE SHV-200 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 21-DEC-2017. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3973 UPDATE SHV-213 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3972 UPDATE SHV-217 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3975 UPDATE SHV-202 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3974 UPDATE SHV-221 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumonia. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3977 UPDATE TEM-9 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3976 UPDATE TEM-5 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3979 UPDATE TEM-32 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3978 UPDATE TEM-31 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1882 UPDATE OXA-80 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-80 is a beta-lactamase found in A. baumannii. UPDATED accession with EU019535.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1904 UPDATE ACT-32 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KM087835.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3629 UPDATE Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam penam; cephamycin; cephalosporin; penicillin; antibiotic target alteration; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ARO_description; ARO_category; model_name; ARO_name "UPDATED ARO_description with Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. UPDATED model_name with Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics UPDATED ARO_name with Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics " 3628 UPDATE Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics penam; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; cephamycin; cefixime; ceftriaxone; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. " 4942 UPDATE OXA-616 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 758 UPDATE OXA-198 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-198 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGCATAAACACATGAGTAAGCTCTTCATCGCTTTTTTAGCCTTTCTGCTGTCGGTGCCAGCAGCCGCTGAAGACCAGACACTTGCCGAGCTCTTTGCCCAACAAGGCATTGACGGGACTATAGTGATTTCGTCGCTACACAACGGAAAGACATTTATCCACAACGATCCCCGCGCAAAACAGAGATTCTCGACAGCATCCACGTTCAAGATACTGAACACGCTGATCTCGCTCGAAGAAAAAGCCATCTCTGGAAAAGACGATGTGCTGAAATGGGACGGGCATATTTACGATTTTCCAGATTGGAATCGTGACCAGACGCTAGAAAGTGCGTTCAAGGTTTCCTGTGTCTGGTGTTATCAGGCGCTTGCACGCCAGGTCGGCGCGGAGAAGTATCGAAATTATTTACGCAAGTCAGTTTACGGAGAATTACGCGAGCCTTTTGAGGAAACAACATTCTGGCTTGATGGTTCACTTCAAATCAGCGCAATTGAACAAGTGAATTTCCTCAAGAAAGTTCATCTGCGCACTCTCCCATTCAGTGCATCGTCCTACGAAACGCTACGACAAATCATGCTTATCGAGCAAACGCCGGCTTTTACGCTGCGGGCCAAGACAGGCTGGGCAACAAGAGTAAAGCCGCAAGTTGGCTGGTATGTGGGCCATGTCGAAACTCCAACGGATGTATGGTTCTTTGCCACGAATATTGAAGTCCGTGACGAAAAAGACTTGCCCTTACGTCAGAAGCTAACGCGAAAAGCATTACAAGCAAAGGGGATCATCGAATAA UPDATED fmax with 3801 UPDATED accession with HQ634775.2 UPDATED fmin with 3012 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with ADT70779.1 UPDATED sequence with MHKHMSKLFIAFLAFLLSVPAAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHNDPRAKQRFSTASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDWNRDQTLESAFKVSCVWCYQALARQVGAEKYRNYLRKSVYGELREPFEETTFWLDGSLQISAIEQVNFLKKVHLRTLPFSASSYETLRQIMLIEQTPAFTLRAKTGWATRVKPQVGWYVGHVETPTDVWFFATNIEVRDEKDLPLRQKLTRKALQAKGIIE UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3623 UPDATE LEN-25 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3622 UPDATE LEN-17 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_description; ARO_category "UPDATED ARO_description with LEN-17 is a beta-lactamase found in Escherichia coli. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3625 UPDATE LEN-36 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3624 UPDATE LEN-35 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3627 UPDATE SHV-4 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3626 UPDATE LEN-37 penam; LEN beta-lactamase; antibiotic inactivation; penem; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3500 UPDATE OXA-417 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4406 UPDATE BSU-1 carbapenem; antibiotic inactivation; BSU beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 474 UPDATE dfrD trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrD is a plasmid-encoded dihydrofolate reductase found in Listeria monocytogenes. UPDATED accession with U43152.1 " 1881 UPDATE OXA-72 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAAAAAATTTATACTTCCTATATTCAGCATTTCTATTCTAGTTTCTCTCAGTGCATGTTCATCTATTAAAACTAAATCTGAAGATAATTTTCATATTTCTTCTCAGCAACATGAAAAAGCTATTAAAAGCTATTTTGATGAAGCTCAAACACAGGGTGTAATTATTATTAAAGAGGGTAAAAATCTTAGCACCTATGGTAATGCTCTTGCACGAGCAAATAAAGAATATGTCCCTGCATCAACATTTAAGATGCTAAATGCTTTAATCGGGCTAGAAAATCATAAAGCAACAACAAATGAGATTTTCAAATGGGATGGTAAAAAAAGAACTTATCCTATGTGGGAGAAAGATATGACTTTAGGTGAGGCAATGGCATTGTCAGCAGTTCCAGTATATCAAGAGCTTGCAAGACGGACTGGCCTAGAGCTAATGCAGAAAGAAGTAAAGCGGGTTAATTTTGGAAATACAAATATTGGAACACAGGTCGATAATTTTTGGTTAGTTGGCCCCCTTAAAATTACACCAGTACAAGAAGTTAATTTTGCCGATGACCTTGCACATAACCGATTACCTTTTAAATTAGAAACTCAAGAAGAAGTTAAAAAAATGCTTCTAATTAAAGAAGTAAATGGTAGTAAGATTTATGCAAAAAGTGGATGGGGAATGGATGTTACTCCACAGGTAGGTTGGTTGACTGGTTGGGTGGAGCAAGCTAATGGAAAAAAAATCCCCTTTTCGCTCAACTTAGAAATGAAAGAAGGAATGTCTGGTTCTATTCGTAATGAAATTACTTATAAGTCGCTAGAAAATCTTGGAATCATTTAA UPDATED fmax with 2033 UPDATED accession with GU199039.2 UPDATED fmin with 1205 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with ADB28892.1 UPDATED sequence with MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4714 UPDATE KLUC-1 antibiotic inactivation; KLUC beta-lactamase; cephalosporin; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4710 UPDATE IMP-85 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4711 UPDATE IMP-88 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5197 UPDATE OXA-904 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1341 UPDATE OXA-53 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-53 is a beta-lactamase found in Salmonella enterica. UPDATED accession with AY289608.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1597 UPDATE SHV-2A carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with X98102.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1596 UPDATE OXA-24 penam; antibiotic inactivation; carbapenem; BAL30072; cephalosporin; monobactam; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF509241.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4396 UPDATE BlaB-34 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1880 UPDATE adeN antibiotic efflux; imipenem; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; trimethoprim; rifamycin antibiotic; penem; macrolide antibiotic; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; ticarcillin; tetracycline antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; model_sequences "UPDATED accession with KF147862.1 " 572 UPDATE OXA-137 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU086834.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 835 UPDATE APH(3')-Ib antibiotic inactivation; aminoglycoside antibiotic; paromomycin; kanamycin A; APH(3'); gentamicin B; lividomycin B; ribostamycin; G418; neomycin; lividomycin A; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(3')-Ib is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. UPDATED accession with M20305.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 3503 UPDATE OXA-430 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1593 UPDATE CMY-99 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-99 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with KF305673.1 " 1342 UPDATE plasmid-encoded cat (pp-cat) antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; ARO_name; model_sequences; model_name; ARO_category "UPDATED ARO_description with Plasmid-encoded cat, or pp-cat, is a plasmid-encoded variant of the cat gene found in Photobacterium damselae subsp. piscicida. UPDATED ARO_name with Plasmid-encoded cat (pp-cat) UPDATED accession with D16171.1 UPDATED model_name with Plasmid-encoded cat (pp-cat) UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1592 UPDATE dfrA14 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli. " 2659 UPDATE Klebsiella pneumoniae acrA penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 4126 UPDATE ACC-1d penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2711 UPDATE MexXY-OprM erythromycin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; penam; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; model_description; ARO_category "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 1278 UPDATE TEM-45 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with X95401.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4909 UPDATE OXA-583 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4908 UPDATE OXA-582 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 947 UPDATE OXA-100 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAACATTAAAGCACTCTTACTTATAACAAGCACTATTTTTATTTCAGCCTGCTCACCTTATATAGTGACTGCTAATCCAAATCACAGCACTTCAAAATCTGATGAAAAAGCAGAGAAAATTAAAAATTTATTTAACGAAGCACACACTACGGGTGTTTTAGTTATCCAACAAGGCCAAACTCAACAAAGCTATGGTAATGATCTTGCTCGTGCTTCGACCGAGTATGTACCTGCTTCGACCTTCAAAATGCTTAATGCTTTGATCGGCCTTGAGCACCATAAGGCAACCACCACAGAAATATTTAAGTGGGACGGGCAAAAAAGGCTGTTCCCAGAATGGGAAAAGGACATGACCCTAGGTGATGCTATGAAAGCTTCCGCTATTCCGGTTTATCAAGATTTAGCTCGTCGTATTGGACTTGAACTCATGTCTAAGGAAGTGAAGCGTGTTGGTTATGGCAATGCAGATATCGGTACCCAAGTCGATAATTTTTGGCTGGTGGGTCCTTTAAAAATTACGCCTCAGCAAGAGGCACAATTTGCTTACAAGCTAGCTAATAAAACGCTTCCATTTAGCCAAAAAGTCCAAGATGAAGTGCAATCCATGCTATTCATAGAAGAAAAGAATGGAAATAAAATATACGCAAAAAGTGGTTGGGGATGGGATGTAGACCCACAAGTAGGCTGGTTAACTGGATGGGTTGTTCAGCCTCAAGGGAATATTGTAGCGTTCTCCCTTAACTTAGAAATGAAAAAAGGAATACCTAGCTCTGTTCGAAAAGAGATTACTTATAAAAGTTTAGAACAATTAGGTATTTTATAG UPDATED fmax with 825 UPDATED accession with AM231720.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with CAJ77817.2 UPDATED sequence with MNIKALLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4679 UPDATE IMP-17 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4678 UPDATE IMI-9 carbapenem; antibiotic inactivation; IMI beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4901 UPDATE OXA-575 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4900 UPDATE OXA-574 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4903 UPDATE OXA-577 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4902 UPDATE OXA-576 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4907 UPDATE OXA-581 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4865 UPDATE OXA-530 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2246 UPDATE vanRI glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanR; ARO_description; model_name; ARO_name "UPDATED ARO_description with Also known as vanRI, is the regulatory transcriptional activator in the vanSR regulator within the vanI glycopeptide resistance gene cluster. UPDATED model_name with vanR gene in vanI cluster UPDATED ARO_name with vanR gene in vanI cluster " 2241 UPDATE vanI glycopeptide antibiotic; glycopeptide resistance gene cluster; Van ligase; antibiotic target alteration; ARO_category "UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 2242 UPDATE vanWI glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanW; ARO_description; model_name; ARO_name "UPDATED ARO_description with Also known as vanWI, is a vanW variant found in the vanI gene cluster. UPDATED model_name with vanW gene in vanI cluster UPDATED ARO_name with vanW gene in vanI cluster " 2243 UPDATE vanXI glycopeptide antibiotic; glycopeptide resistance gene cluster; vanX; antibiotic target alteration; ARO_description; model_name; ARO_name "UPDATED ARO_description with Also known as vanXI, is a vanX variant found in the vanI glycopeptide resistance gene cluster. It is a D-Ala-D-Ala dipeptidase. UPDATED model_name with vanX gene in vanI cluster UPDATED ARO_name with vanX gene in vanI cluster " 995 UPDATE MexG antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; tetracycline antibiotic; fluoroquinolone antibiotic; disinfecting agents and antiseptics; tetracycline; ARO_category; model_name "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 UPDATED model_name with MexG " 994 UPDATE SHV-77 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGCGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 891 UPDATED accession with AM176552.2 UPDATED fmin with 30 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47132.2 UPDATED sequence with MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVALCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 997 UPDATE VIM-31 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-31 is a beta-lactamase found in Enterobacter cloacae. UPDATED accession with JN982330.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 996 UPDATE CMY-77 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JX440353.1 " 990 UPDATE FOX-9 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; model_sequences; ARO_category "UPDATED accession with JF896803.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 5149 UPDATE OXA-852 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5146 UPDATE OXA-848 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5147 UPDATE OXA-849 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5144 UPDATE OXA-845 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5145 UPDATE OXA-847 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5142 UPDATE OXA-843 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5143 UPDATE OXA-844 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5140 UPDATE OXA-841 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5141 UPDATE OXA-842 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3400 UPDATE vga(E) Staphylococcus cohnii dalfopristin; pleuromutilin; virginiamycin M1; pleuromutilin antibiotic; madumycin II; griseoviridin; ABC-F ATP-binding cassette ribosomal protection protein; macrolide antibiotic; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; ARO_description; ARO_category "UPDATED ARO_description with vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci. UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 3403 UPDATE Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide antibiotic target alteration; pyrazinamide resistant rpsA; pyrazinamide; model_name "UPDATED model_name with Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide " 3405 UPDATE OXA-402 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 125 UPDATE SHV-182 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP050489.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3407 UPDATE OXA-103 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3406 UPDATE OXA-140 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3409 UPDATE OXA-123 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3408 UPDATE OXA-122 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4874 UPDATE OXA-545 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4877 UPDATE OXA-548 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4876 UPDATE OXA-547 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4871 UPDATE OXA-537 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4873 UPDATE OXA-542 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4872 UPDATE OXA-538 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5018 UPDATE OXA-706 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4879 UPDATE OXA-550 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4878 UPDATE OXA-549 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5680 UPDATE VEB-19 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_category "UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 2068 UPDATE Escherichia coli 16S rRNA mutation conferring resistance to edeine 16s rRNA with mutation conferring resistance to peptide antibiotics; edeine B; edeine F; edeine D; peptide antibiotic; antibiotic target alteration; edeine A; ARO_description; model_sequences "UPDATED ARO_description with Point mutations in the 3' minor domain of the 16S rRNA in Escherichia coli can confer resistance to edeine. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 " 3377 UPDATE rmtE antibiotic target alteration; aminoglycoside antibiotic; 16S rRNA methyltransferase (G1405); ARO_description "UPDATED ARO_description with Aminoglycoside-resistance gene. " 3415 UPDATE OXA-151 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 576 UPDATE MIR-5 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP050484.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 3376 UPDATE rmtD2 antibiotic target alteration; aminoglycoside antibiotic; 16S rRNA methyltransferase (G1405); ARO_description; model_sequences "UPDATED ARO_description with The first allele of a 16S rRNA methyltransferase gene, rmtD2, confers a high resistance to all clinically available aminoglycosides. UPDATED partial with 0 UPDATED sequence with ATGAGCGAACTGAAGGAAAAACTGCTCGCTTCGAAAAAATATCGCGACGTTTGCCCGGACACGATCGAGCGCATATGGCGTGAATGCAGCGCGAAATTCAAAAAGGAAAAGGACGCGGACAAGGCGGCGCGCGAAGCGCTTCACGGTGTGACCGGCGCGTTCATGACCGAGCGCGAATACAAACGCGCGATGGAACTGGCGGCGACACGCGATTGGGAAGCGCTGCTTGGAATGCACGCGTCCACGCGCGAACGGCTGCCGGTGGAATCGATGGATCGCGTGTTCGATCAGCTGTTTGAAGCCATCGGAACGCCGGCGCGAATTCTCGATCTCGCGTGCGGGCTGAATCCGGTCTACCTCGCGCATCGATTGCCAAATGCGGCGATTGCCGGCGTGGATATCAGCGGTCAGTGCGTAAACGTAATTCGCGCGTTTGGCGGCGCGGAAGCGCGTTTGGGCGATTTGCTGTGCGAAATTCCGGAAGACGAAGCGGATGCGGCGCTGATGTTTAAGGTGCTGCCGCTTTTGGAGCGCCAGCGCACGGGCGCGGCGATGGAAGCGCTAATGCGTGTGAATGCGGAATGGATCGTCGCATCGTTTCCGACGCGTTCACTCGGCGGGCGCAACGTCGGCATGGAAAAGCACTATTCCGAATGGATGGAGGCGCACGTGCCGGAAAATCGCGCGATTGCCGCGCGGCTGACCGGCGAAAACGAGCTGTTTTACGTGCTGAAACGAAAATGA UPDATED fmax with 14882 UPDATED accession with HQ401565.1 UPDATED fmin with 14138 UPDATED strand with - UPDATED NCBI_taxonomy_name with Klebsiella aerogenes UPDATED NCBI_taxonomy_id with 548 UPDATED NCBI_taxonomy_cvterm_id with 36770 UPDATED accession with ADW66527.1 UPDATED sequence with MSELKEKLLASKKYRDVCPDTIERIWRECSAKFKKEKDADKAAREALHGVTGAFMTEREYKRAMELAATRDWEALLGMHASTRERLPVESMDRVFDQLFEAIGTPARILDLACGLNPVYLAHRLPNAAIAGVDISGQCVNVIRAFGGAEARLGDLLCEIPEDEADAALMFKVLPLLERQRTGAAMEALMRVNAEWIVASFPTRSLGGRNVGMEKHYSEWMEAHVPENRAIAARLTGENELFYVLKRK " 2793 UPDATE Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; erythromycin; model_name "UPDATED model_name with Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin " 2790 UPDATE Serratia marcescens Omp1 penam; carbapenem; reduced permeability to antibiotic; General Bacterial Porin with reduced permeability to beta-lactams; penem; resistance by absence; phenicol antibiotic; cefotaxime; tetracycline antibiotic; cephalosporin; cephamycin; ciprofloxacin; moxalactam; monobactam; fluoroquinolone antibiotic; ceftriaxone; cefoxitin; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). " 2796 UPDATE OprZ antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cefepime; fluoroquinolone antibiotic; aminoglycoside antibiotic; erythromycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAACCCGTGGCAATGACCCTGCTGGCGCTGGCATTGTCCGGCTGCTCGCTGGCGCCCACCCATGAGCGCCCCGCGGCGCCGGTGCCGGCGCAGTACGACACGCCGGCGCAGCCCGGCCAGGCCGCCGCGCCGCAGGACTGGCGCGCCTATTTCAACGATCCGGCGCTGCAGGCCTGGATCGCGGCCGCGCTGGCCAACAACCGCGACCTGCGCGTGGCGGCGCTGCGCATCGAGGAAGCGCGCGCGCTGTACGGCGTGCAGCAATCCGAACGCCTGCCGGCCATCGACGCCAGCGGCGAATTCAGCCGCGGCCGCGCGACCGAGCCGGGCCAGCCGCGCACGCCGGTGTCCAACCGCTACCGCGCGGCCGTCGGCATCACCGCGTTCGAGCTGGACTTCTTCGGCCGGGTGCGGAGCCTGTCGGACGCCGCGCTGGCGCGCTACCTGGCCAGCGAGGAAGCGCACCGCGCCGCCACGCTGGCGCTGGTGGCGGAGACGGCGACGGCCTACTTCAACCAGCGTTCGCTGGCCGAGCAACTGCGCCTGACCGACGACACGCTGGCGCTGCGCGAGACCACGCTCAAGCTGACCCAGCGCCGCTACGACGCCGGGCTGGAAACCGCCATCGGCCTGCGCACCGCGCAGATGCTGGTGGAAAGCTCGCGCGCCACGCGCGCCGAGCTGACCCGCGAGGCCAGCCTGGCGCGGCACGCGCTGGGCCTGCTGGCCGGCGATTTCGCGCTGCCGCTCGGCGTCGACCCTACGCCGCTGGAAAGCCAGAGCCTGACGCCGCTGGCGGCGGGGCTGCCGTCCGAACTGCTGACGCGCCGCCCCGACCTGCGCCAGGCAGAGCAGGCGCTGCGCGCGGCCAACGCCGACATCGGCGCGGCGCGCGCGGCGTTCTTCCCGTCGGTGCAGCTGACCACGGACATCGGCACCACCGCCGACCGCTTCTCGGATCTGTTCAGCGGCGGCACCGGCGGCTGGAGCTTCGCGCCGCGCCTGACGCTGCCGATCTTCAACGCCGGCCGCAACCGCGCCAACCTGTCGCTGGCCGAGACCCGCAAGCACATCGCGGTGGCCCAGTACGAAGGCAGCATCCAGGCCGCGTTCCGCGACGTGGCCGACGCGCTGTCGGCGCGCGACGCGCTGCGCGACCAGATCGAGGCCCAGCGCAAGGTGCGCGACGCCGACCGCGAACGCCAGCGGCTGGCCGAGCGGCGTTATGCGCGCGGGGTGGCGAACTACCTGGAGATGCTGGAGGCCCAGCGCAGCCTGTTCGAGTCGGAACAGGAATTCATCCGGCTGCAGCAGCGCCGGCTGGTCAACGCGGTGGATCTGTACAAGGCGCTGGGCGGCTGGGACGACGGCTCATCGCCGGCGTCCTGA UPDATED fmax with 23990 UPDATED accession with AFRQ01000061.1 UPDATED fmin with 22598 UPDATED strand with - UPDATED NCBI_taxonomy_name with Achromobacter insuavis AXX-A UPDATED NCBI_taxonomy_id with 1003200 UPDATED NCBI_taxonomy_cvterm_id with 41271 UPDATED accession with EGP45230.2 UPDATED sequence with MKPVAMTLLALALSGCSLAPTHERPAAPVPAQYDTPAQPGQAAAPQDWRAYFNDPALQAWIAAALANNRDLRVAALRIEEARALYGVQQSERLPAIDASGEFSRGRATEPGQPRTPVSNRYRAAVGITAFELDFFGRVRSLSDAALARYLASEEAHRAATLALVAETATAYFNQRSLAEQLRLTDDTLALRETTLKLTQRRYDAGLETAIGLRTAQMLVESSRATRAELTREASLARHALGLLAGDFALPLGVDPTPLESQSLTPLAAGLPSELLTRRPDLRQAEQALRAANADIGAARAAFFPSVQLTTDIGTTADRFSDLFSGGTGGWSFAPRLTLPIFNAGRNRANLSLAETRKHIAVAQYEGSIQAAFRDVADALSARDALRDQIEAQRKVRDADRERQRLAERRYARGVANYLEMLEAQRSLFESEQEFIRLQQRRLVNAVDLYKALGGWDDGSSPAS " 2794 UPDATE Helicobacter pylori 23S rRNA with mutation conferring resistance to clarithromycin antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; ARO_description; model_param "UPDATED ARO_description with Point mutations in Helicobacter pylori shown to confer resistance to clarithromycin, a macrolide antibiotic. UPDATED 12514 with A2143G UPDATED 12515 with A1410G UPDATED 12516 with A2167G UPDATED 12517 with C1707T UPDATED 12518 with C2922T UPDATED 12514 with A2143G UPDATED 12515 with A1410G UPDATED 12516 with A2167G UPDATED 12517 with C1707T UPDATED 12518 with C2922T UPDATED 12519 with C2248T,G2287A UPDATED param_type_id with 40330 UPDATED param_type with multiple resistance variants UPDATED param_description with A set of nucleotide or amino acid substitutions that are each required to confer resistance to an antibiotic drug or drug class by co-mutation. Compare to single resistance variant, where only one substitution is required. Multiple resistance variants parameters are indicated on appropriate models using the following notation: [wild-type 1][position 1][mutation 1],[wild-type 2][position 2][mutation 2],...,[wild-type n][position n][mutation n]. When each included substitution is detected in a protein sequence, resistance is conferred. This parameter is not currently included in any detection algorithms. " 3413 UPDATE OXA-127 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1346 UPDATE SHV-94 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF373970.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3374 UPDATE aphA15 antibiotic inactivation; streptomycin; kanamycin A; APH(3'); netilmicin; amikacin; aminoglycoside antibiotic; G418; neomycin; ARO_description; ARO_category "UPDATED ARO_description with Expression of cloned aphA15 gene in Escherichia coli reduced the susceptibility to kanamycin and neomycin, as well as to amikacin, netilmicin, and streptomycin. UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 3410 UPDATE OXA-124 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2960 UPDATE OXA-663 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3411 UPDATE OXA-125 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3950 UPDATE SHV-226 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4030 UPDATE PDC-293 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-293 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 2306 UPDATE Escherichia coli acrR with mutation conferring multidrug antibiotic resistance penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category; ARO_name "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. UPDATED ARO_name with Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime " 5098 UPDATE OXA-793 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5099 UPDATE OXA-794 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3578 UPDATE CMY-133 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description "UPDATED ARO_description with From Lahey's list of beta-lactamases, no additional information available. " 727 UPDATE ErmS antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with ErmS is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers two methyl groups. The gene is found within the tylosin biosynthetic cluster and is responsible for self-resistance. UPDATED accession with M19269.1 " 5090 UPDATE OXA-782 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5091 UPDATE OXA-783 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5092 UPDATE OXA-784 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5093 UPDATE OXA-785 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5094 UPDATE OXA-786 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5095 UPDATE OXA-787 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5096 UPDATE OXA-788 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 940 UPDATE TEM-125 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY628176.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2482 UPDATE Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin antibiotic target alteration; streptomycin; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; model_name "UPDATED model_name with Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin " 3257 UPDATE dfrB5 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with A dihydrofolate reductase and trimethoprim resistance gene identified from an integron in Pseudomonas aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGGACCAAGGCAGAAGTGAAGTCAGTAATCCAGTTGCTGGCCAGTTTGCGTTCCCTTCAAACGCCGCGTTCGGAATGGGAGATCGCGTGCGCAAGAAATCTGGCGCCGCTTGGCAAGGCCAGATTGTCGGGTGGTACTGCACAAAATTGACCCCTGAAGGGTACGCTGTCGAGTCTGAGGCTCACCCTGGCTCGGTACAGATTTATCCTGTTGCGGCACTGGAACGCATCAACTGA UPDATED fmax with 3092 UPDATED accession with AY943084.1 UPDATED fmin with 2855 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AAX46054.1 UPDATED sequence with MDQGRSEVSNPVAGQFAFPSNAAFGMGDRVRKKSGAAWQGQIVGWYCTKLTPEGYAVESEAHPGSVQIYPVAALERIN " 1397 UPDATE dfrC trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description "UPDATED ARO_description with dfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus. " 1115 UPDATE OXA-435 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KP144324.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5657 UPDATE SHV-190 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1645 UPDATE ACT-23 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACT-23 is a beta-lactamase found in Escherichia coli. UPDATED accession with KF515536.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1644 UPDATE SHV-70 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ013287.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2152 UPDATE Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences "UPDATED ARO_description with Point mutations in the 16S rRNA of Neisseria meningitidis can confer resistance to spectinomycin. UPDATED accession with NC_003112.1 " 1646 UPDATE TEM-139 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ072853.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1641 UPDATE OXA-203 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-203 is a beta-lactamase found in A. baumannii. UPDATED accession with HQ998857.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1640 UPDATE MIR-14 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087864.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 3264 UPDATE dfrB7 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with A dihydrofolate reductase and trimethoprim resistance gene identified on an integron in multidrug-resistant gram-negative bacteria. UPDATED partial with 0 UPDATED sequence with ATGGACCAAGGTAGCAATGAAGTCGGTAATCCAGTTGCGGGCCAGTTTTCGTTCCCATCGAACGCCGCGTTTAGTATGGGAGATCGCGTGCGCAAGAAATCGGGCGCCGCTTGGCAAGGTCAGATTGTCGGGTGGTACTGCACAAAGTTGACCCCTGAAGGCTACGCTGTCGAGTCTGAGGCTCACCCTGGCTCGGTACAGATTTATCCTGTTGCGGCGCTTGAACGCATCAACGGAGTTCAAGGTTGA UPDATED fmax with 1296 UPDATED accession with GU295656.1 UPDATED fmin with 1047 UPDATED strand with + UPDATED NCBI_taxonomy_name with Aeromonas hydrophila UPDATED NCBI_taxonomy_id with 644 UPDATED NCBI_taxonomy_cvterm_id with 36810 UPDATED accession with ADB54781.1 UPDATED sequence with MDQGSNEVGNPVAGQFSFPSNAAFSMGDRVRKKSGAAWQGQIVGWYCTKLTPEGYAVESEAHPGSVQIYPVAALERINGVQG " 1642 UPDATE clbC dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with clbC is a plasmid-encoded cfr gene found in Alkalihalobacillus clausii. UPDATED NCBI_taxonomy_name with Alkalihalobacillus clausii KSM-K16 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 1396 UPDATE OXA-11 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with Z22590.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1648 UPDATE CTX-M-2 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-2 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED partial with 0 UPDATED sequence with ATGATGACTCAGAGCATTCGCCGCTCAATGTTAACGGTGATGGCGACGCTACCCCTGCTATTTAGCAGCGCAACGCTGCATGCGCAGGCGAACAGCGTGCAACAGCAGCTGGAAGCCCTGGAGAAAAGTTCGGGAGGTCGGCTTGGCGTTGCGCTGATTAACACCGCCGATAATTCGCAGATTCTCTACCGTGCCGATGAACGTTTTGCGATGTGCAGTACCAGTAAGGTGATGGCGGCCGCGGCGGTGCTTAAACAGAGCGAGAGCGATAAGCACCTGCTAAATCAGCGCGTTGAAATCAAGAAGAGCGACCTGGTTAACTACAATCCCATTGCGGAGAAACACGTTAACGGCACGATGACGCTGGCTGAGCTTGGCGCAGCGGCGCTGCAGTATAGCGACAATACTGCCATGAATAAGCTGATTGCCCATCTGGGTGGTCCCGATAAAGTGACGGCGTTTGCTCGCTCGTTGGGTGATGAGACCTTCCGTCTGGACAGAACCGAGCCCACGCTCAATACCGCCATTCCAGGCGACCCGCGTGATACCACCACGCCGCTCGCGATGGCGCAGACCCTGAAAAATCTGACGCTGGGTAAAGCGCTGGCGGAAACTCAGCGGGCACAGTTGGTGACGTGGCTTAAGGGCAATACTACCGGTAGCGCGAGCATTCGGGCGGGTCTGCCGAAATCATGGGTAGTGGGCGATAAAACCGGCAGCGGAGATTATGGCACCACCAACGATATCGCGGTTATCTGGCCGGAAAACCACGCACCGCTGGTTCTGGTGACCTACTTTACCCAACCGGAGCAGAAGGCGGAAAGCCGTCGGGATATTCTGGCTGCGGCGGCGAAAATCGTAACCCACGGTTTCTGA UPDATED fmax with 7708 UPDATED accession with DQ125241.2 UPDATED fmin with 6832 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAZ95872.1 UPDATED sequence with MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF " 728 UPDATE TEM-192 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JF949915.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1526 UPDATE AAC(6')-Iaa AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(6')-Iaa is a chromosomal-encoded aminoglycoside acetyltransferase in S. typhimurium. " 1743 UPDATE OXA-338 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF048909.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5654 UPDATE SHV-132 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1838 UPDATE ACT-5 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ACT-5 is a beta-lactamase found in Escherichia coli. UPDATED accession with FJ237369.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1926 UPDATE CMY-34 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-34 is a beta-lactamase found in Escherichia coli. UPDATED accession with EF394370.1 " 579 UPDATE vgaA dalfopristin; pleuromutilin; virginiamycin M1; pleuromutilin antibiotic; madumycin II; griseoviridin; ABC-F ATP-binding cassette ribosomal protection protein; macrolide antibiotic; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 578 UPDATE SHV-11 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with X98101.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 573 UPDATE OXA-136 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with EU086830.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4428 UPDATE CARB-44 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 571 UPDATE clbA dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 570 UPDATE Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides sulfadiazine; sulfadoxine; sulfacetamide; sulfadimidine; mafenide; sulfonamide resistant dihydropteroate synthase folP; sulfisoxazole; antibiotic target alteration; sulfamethizole; sulfasalazine; sulfamethoxazole; sulfonamide antibiotic; model_sequences; ARO_category "UPDATED accession with AE009949.1 UPDATED category_aro_description with Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. " 607 UPDATE TEM-201 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX310327.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 575 UPDATE AAC(3)-Ib antibiotic inactivation; AAC(3); aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(3)-Ib is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED accession with L06157.1 " 574 UPDATE AAC(6')-Ia AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; model_sequences "UPDATED accession with M18967.1 " 2808 UPDATE Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; ARO_description "UPDATED ARO_description with Point mutation in the 23S rRNA of Propionibacteria shown clinically to confer resistance to macrolides. " 2802 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin antibiotic target alteration; telithromycin; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; erythromycin; model_name "UPDATED model_name with Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin " 2803 UPDATE Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid antibiotic target alteration; Para-aminosalicylic acid; aminosalicylate resistant thymidylate synthase; ARO_category "UPDATED category_aro_name with Para-aminosalicylic acid UPDATED category_aro_description with Para-aminosalicylic acid (PAS) is an anti-tubercular antibiotic agent, often used in conjunction with Isoniazid for treatment of M. tuberculosis infections. PAS diminishes bacterial cell growth by limiting folic acid production. " 5655 UPDATE SHV-146 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2806 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to clindamycin antibiotic target alteration; clindamycin; 23S rRNA with mutation conferring resistance to lincosamide antibiotics; lincosamide antibiotic; ARO_description "UPDATED ARO_description with Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clindamycin, a lincosamide antibiotic. " 2807 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to clarithromycin antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; ARO_description "UPDATED ARO_description with Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clarithromycin, a macrolide antibiotic. " 2804 UPDATE Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid antibiotic target alteration; aminosalicylate resistant dihydrofolate synthase; Para-aminosalicylic acid; ARO_category "UPDATED category_aro_name with Para-aminosalicylic acid UPDATED category_aro_description with Para-aminosalicylic acid (PAS) is an anti-tubercular antibiotic agent, often used in conjunction with Isoniazid for treatment of M. tuberculosis infections. PAS diminishes bacterial cell growth by limiting folic acid production. " 2805 UPDATE Mycoplasma gallisepticum 23S rRNA mutation conferring resistance to pleuromutilin antibiotics 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics; pleuromutilin; antibiotic target alteration; pleuromutilin antibiotic; ARO_category "UPDATED category_aro_description with Point mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics. " 4981 UPDATE OXA-661 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4980 UPDATE OXA-660 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3360 UPDATE catB11 antibiotic inactivation; phenicol antibiotic; chloramphenicol acetyltransferase (CAT); chloramphenicol; ARO_category "UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 2156 UPDATE NDM-14 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3362 UPDATE Staphylococcus aureus FosB fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; ARO_description "UPDATED ARO_description with The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein. " 3363 UPDATE MCR-3.3 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with MCR-3.3 is a colistin resistance gene variant in the chromosome of an Aeromonas veronii. Conferred polymyxin resistance in both E. Coli and Aeromonas salmonicida. " 731 UPDATE IMP-11 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with AB074436.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 730 UPDATE AAC(6')-IIc AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-IIc is an aminoglycoside acetyltransferase encoded by plasmids and integrons in E. cloacae. UPDATED accession with AF162771.1 " 4883 UPDATE OXA-554 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2157 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C antibiotic target alteration; gentamicin C; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to gentamicin C. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C " 735 UPDATE TEM-30 penam; antibiotic inactivation; monobactam; penem; cephalosporin; cefalotin; amoxicillin; ampicillin; clavulanic acid; TEM beta-lactamase; amoxicillin-clavulanic acid; model_sequences; ARO_category "UPDATED accession with AJ437107.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 734 UPDATE vanTC glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanT; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanTC, is a vanT variant found in the vanC gene cluster. UPDATED accession with AF162694.1 UPDATED model_name with vanT gene in vanC cluster UPDATED ARO_name with vanT gene in vanC cluster " 736 UPDATE arr-7 antibiotic inactivation; rifampin; rifapentine; rifabutin; rifampin ADP-ribosyltransferase (Arr); rifaximin; rifamycin antibiotic; ARO_description; model_sequences "UPDATED ARO_description with arr-7 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. UPDATED accession with FN397623.1 " 739 UPDATE LRA-18 penam; antibiotic inactivation; cephalosporin; class C LRA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with LRA-18 is a beta-lactamase isolated from soil samples in Alaska. UPDATED accession with EU408355.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 738 UPDATE AAC(6')-Iae AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iae is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa and S. enterica. UPDATED accession with AB104852.1 " 1217 UPDATE OXA-139 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM991978.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3390 UPDATE MCR-3.4 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with A plasmid-mediated MCR-3.1 variant. " 4984 UPDATE OXA-667 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2400 UPDATE oqxB antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; trimethoprim; efflux pump complex or subunit conferring antibiotic resistance; diaminopyrimidine antibiotic; tigecycline; glycylcycline; ciprofloxacin; tetracycline antibiotic; nitrofuran antibiotic; fluoroquinolone antibiotic; nitrofurantoin; ARO_description "UPDATED ARO_description with RND efflux pump conferring resistance to fluoroquinolone. " 465 UPDATE vanSO glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSO, is a vanS variant found in the vanO gene cluster. UPDATED accession with KF478993.1 UPDATED model_name with vanS gene in vanO cluster UPDATED ARO_name with vanS gene in vanO cluster " 464 UPDATE NDM-13 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; model_sequences; ARO_category "UPDATED accession with LC012596.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1357 UPDATE CTX-M-132 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JX313020.1 " 460 UPDATE CMY-29 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-29 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGTTCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA UPDATED fmax with 1143 UPDATED accession with EF685371.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ABS12248.1 UPDATED sequence with MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQFPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ " 1355 UPDATE TEM-149 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ369751.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 462 UPDATE Staphylococcus aureus pgsA mutations conferring resistance to daptomycin peptide antibiotic; antibiotic target alteration; daptomycin resistant pgsA; daptomycin; ARO_description "UPDATED ARO_description with Point mutations that occur within Staphylococcus aureus pgsA gene resulting in resistance to daptomycin. " 933 UPDATE OKP-A-14 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-14 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with FJ534512.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 5653 UPDATE SHV-116 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 932 UPDATE GES-8 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with GES-8 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AF329699.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 3393 UPDATE MCR-4.3 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with A plasmid-mediated MCR-4 variant and colistin resistance gene from clinical Enterobacteriaceae. " 4905 UPDATE OXA-579 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1273 UPDATE otr(A) tetracycline antibiotic; tetracycline-resistant ribosomal protection protein; antibiotic target protection; ARO_description; model_sequences "UPDATED ARO_description with otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus. UPDATED accession with X53401.1 " 4861 UPDATE OXA-526 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4866 UPDATE OXA-531 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4955 UPDATE OXA-629 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5650 UPDATE SGM-7 carbapenem; antibiotic inactivation; SGM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4864 UPDATE OXA-529 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1515 UPDATE NDM-3 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with NDM-3 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with JQ734687.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1514 UPDATE IMP-28 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-28 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with JQ407409.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1517 UPDATE OXA-33 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY008291.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2409 UPDATE Neisseria meningititis PBP2 conferring resistance to beta-lactam penam; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; cephamycin; cefixime; ceftriaxone; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. " 1274 UPDATE VIM-10 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY524989.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1510 UPDATE vanTrL glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanT; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanTrL, is a vanT variant found in the vanL gene cluster. vanTrL codes for the racemase component of vanT. UPDATED accession with EU250284.1 UPDATED model_name with vanTr gene in vanL cluster UPDATED ARO_name with vanTr gene in vanL cluster " 1513 UPDATE QnrB64 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB64 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with KC580653.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1512 UPDATE SME-3 carbapenem; antibiotic inactivation; SME beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with SME-3 is a beta-lactamase found in Serratia marcescens. UPDATED accession with AY584237.1 " 1903 UPDATE mdtE penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; oxacillin; cloxacillin; fluoroquinolone antibiotic; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 959 UPDATE OXA-64 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-64 is a beta-lactamase found in A. baumannii. UPDATED accession with AY750907.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5129 UPDATE OXA-827 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 281 UPDATE CMY-110 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description "UPDATED ARO_description with CMY-110 is a beta-lactamase found in Escherichia coli. " 3439 UPDATE OXA-272 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1253 UPDATE GES-23 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF179354.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. " 3395 UPDATE MCR-4.5 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with A plasmid-mediated MCR-4 variant and colistin resistance gene. " 1735 UPDATE vatA dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with vatA is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. UPDATED accession with L07778.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. " 4859 UPDATE OXA-524 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1511 UPDATE OXA-423 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM433672.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3394 UPDATE MCR-4.4 peptide antibiotic; MCR phosphoethanolamine transferase; antibiotic target alteration; colistin B; colistin A; ARO_description "UPDATED ARO_description with A plasmid-mediated MCR-4 variant and colistin resistance gene. " 4858 UPDATE OXA-523 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1276 UPDATE OXA-210 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with JF795487.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5646 UPDATE SGM-3 carbapenem; antibiotic inactivation; SGM beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1896 UPDATE NDM-12 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AB926431.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 582 UPDATE FOX-7 antibiotic inactivation; cephamycin; cephalosporin; FOX beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with FOX-7 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AJ703795.1 UPDATED category_aro_description with FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. " 3501 UPDATE OXA-427 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2069 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to neomycin. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin " 985 UPDATE ErmA antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 716 UPDATE QnrB32 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB32 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JN173054.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 4019 UPDATE PDC-285 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-285 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4018 UPDATE PDC-346 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-346 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4661 UPDATE GOB-49 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4013 UPDATE PDC-323 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-323 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4012 UPDATE PDC-324 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-324 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4011 UPDATE PDC-384 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-384 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4010 UPDATE PDC-118 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-118 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4017 UPDATE PDC-201 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-201 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4016 UPDATE PDC-264 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-264 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4015 UPDATE PDC-413 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-413 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 4014 UPDATE PDC-258 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; ARO_description "UPDATED ARO_description with PDC-258 is a class C beta-lactamase found in Pseudomonas aeruginosa. " 357 UPDATE VIM-38 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-38 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGTTAAAAGTTATTAGTAGTTTATTGGTCTATTTGACCGCGTCTGTCATGGCTGTAGCTAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGGCTTTACCAGATTGCTGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCGGTCTACCCATCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCCCTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGAAGGCTGGAGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCCGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAACGTGCTATACGGTGGTTGTGCCGTTCTTGCGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCACAGCACACAAAAATCGCTCAGTCGTTGAGTAG UPDATED fmax with 801 UPDATED accession with KC469971.2 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AGE83081.2 UPDATED sequence with MLKVISSLLVYLTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRKAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLALSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVTAHKNRSVVE UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 355 UPDATE TEM-1 penam; antibiotic inactivation; monobactam; penem; cephalosporin; cefazolin; piperacillin-tazobactam; cefalotin; amoxicillin; ampicillin; clavulanic acid; piperacillin; tazobactam; TEM beta-lactamase; amoxicillin-clavulanic acid; model_sequences; ARO_category "UPDATED accession with AL513383.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 354 UPDATE QnrB24 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB24 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with HM192542.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3988 UPDATE TEM-225 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3989 UPDATE TEM-226 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with TEM-226 is a beta lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 351 UPDATE SHV-6 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with Y11069.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 350 UPDATE ykkD antibiotic efflux; small multidrug resistance (SMR) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; streptomycin; aminoglycoside antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with ykkD is an SMR-type protein that is a subunit of the ykkCD efflux pump. UPDATED accession with AL009126.1 " 4420 UPDATE CARB-34 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3986 UPDATE TEM-212 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3987 UPDATE TEM-224 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with TEM-224 is a beta-lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3980 UPDATE TEM-35 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3981 UPDATE TEM-36 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3982 UPDATE TEM-37 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3983 UPDATE TEM-39 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4833 UPDATE OXA-497 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 45 UPDATE mdtP antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; puromycin; acriflavine; nucleoside antibiotic; disinfecting agents and antiseptics; ARO_description; ARO_category "UPDATED ARO_description with Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3612 UPDATE HERA-3 penam; HERA beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 43 UPDATE tet(42) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with EU523697.1 " 4855 UPDATE OXA-520 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3613 UPDATE HERA-4 penam; HERA beta-lactamase; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1354 UPDATE Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol ethambutol resistant embA; antibiotic target alteration; ethambutol; polyamine antibiotic; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Specific mutations that occurs on Mycobacterium tuberculosis embA leading to the lowered affinity of ethambutol to embA. UPDATED accession with CP003248.1 UPDATED category_aro_description with Mutations that occurs on the embA genes resulting in the resistance to ethambutol. " 4421 UPDATE CARB-35 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 41 UPDATE rmtH antibiotic target alteration; aminoglycoside antibiotic; 16S rRNA methyltransferase (G1405); ARO_description; model_sequences "UPDATED ARO_description with rmtH is a 16s ribosomal RNA methyltransferase found in Klebsiella pneumoniae strain MRSN2404 that was isolated from the chronic wound of a soldier wounded in Iraq in 2006. It confers high resistance to all aminoglycosides. UPDATED accession with KC544262.1 " 1033 UPDATE vanSN glycopeptide antibiotic; vanS; antibiotic target alteration; glycopeptide resistance gene cluster; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanSN, is a vanS variant found in the vanN gene cluster. UPDATED accession with JF802084.1 UPDATED model_name with vanS gene in vanN cluster UPDATED ARO_name with vanS gene in vanN cluster " 4707 UPDATE IMP-82 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4706 UPDATE IMP-81 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4705 UPDATE IMP-80 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4704 UPDATE IMP-79 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4703 UPDATE IMP-78 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4702 UPDATE IMP-77 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4701 UPDATE IMP-76 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4700 UPDATE IMP-75 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3504 UPDATE OXA-431 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2329 UPDATE MOX-9 penam; antibiotic inactivation; MOX beta-lactamase; cephamycin; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2328 UPDATE MUS-2 carbapenem; antibiotic inactivation; MUS beta-lactamase; model_name "UPDATED model_name with MUS-2 " 1445 UPDATE AcrE penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; ciprofloxacin; fluoroquinolone antibiotic; model_sequences; model_name; ARO_category "UPDATED accession with U00096.1 UPDATED model_name with AcrE UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4709 UPDATE IMP-84 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4854 UPDATE OXA-519 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 289 UPDATE OXA-85 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-85 is a beta-lactamase found in Fusobacterium nucleatum. UPDATED accession with AY227054.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2293 UPDATE Bacillus subtilis pgsA with mutation conferring resistance to daptomycin peptide antibiotic; antibiotic target alteration; daptomycin resistant pgsA; daptomycin; model_name "UPDATED model_name with Bacillus subtilis pgsA with mutation conferring resistance to daptomycin " 1444 UPDATE IND-12 carbapenem; antibiotic inactivation; IND beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IND-12 is a beta-lactamase found in Escherichia coli. UPDATED accession with HM245380.1 UPDATED category_aro_description with IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. " 754 UPDATE CTX-M-48 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-48 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY847144.1 " 4426 UPDATE CARB-42 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1793 UPDATE DHA-14 antibiotic inactivation; cephalosporin; cephamycin; DHA beta-lactamase; model_sequences "UPDATED accession with KM087854.1 " 280 UPDATE CTX-M-11 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with AY005110.1 " 283 UPDATE CMY-85 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KJ207202.1 " 282 UPDATE CTX-M-125 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-125 is a beta-lactamase found in Escherichia coli. UPDATED accession with JQ724542.1 " 285 UPDATE TEM-11 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY874537.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 284 UPDATE smeD antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; tetracycline antibiotic; fluoroquinolone antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia. UPDATED accession with AJ252200.1 " 287 UPDATE TEM-67 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCATTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATAAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTTGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA UPDATED fmax with 1311 UPDATED accession with AF091113.2 UPDATED fmin with 450 UPDATED strand with + UPDATED NCBI_taxonomy_name with Proteus mirabilis UPDATED NCBI_taxonomy_id with 584 UPDATED NCBI_taxonomy_cvterm_id with 36771 UPDATED accession with AAD33116.2 UPDATED sequence with MSIQHFRVALIPFFAAFCIPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSCGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1442 UPDATE mdtN antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; puromycin; acriflavine; nucleoside antibiotic; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3761 UPDATE LMB-1 carbapenem; penam; LMB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3762 UPDATE IMP-68 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3766 UPDATE FRI-4 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4415 UPDATE CARB-29 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3768 UPDATE FRI-6 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3769 UPDATE FRI-7 FRI beta-lactamase; penam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1440 UPDATE CTX-M-103 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-103 is a beta-lactamase found in Escherichia coli. UPDATED accession with HG423149.1 " 263 UPDATE dfrA24 trimethoprim; diaminopyrimidine antibiotic; trimethoprim resistant dihydrofolate reductase dfr; antibiotic target replacement; ARO_description; model_sequences "UPDATED ARO_description with dfrA24 is an integron-encoded dihydrofolate reductase found in Escherichia coli. UPDATED accession with AJ972619.1 " 262 UPDATE VIM-8 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-8 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with AY524987.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 261 UPDATE CMY-65 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with JF780936.1 " 260 UPDATE ErmN antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 267 UPDATE OXA-43 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-43 is a beta-lactamase found in Burkholderia pseudomallei. UPDATED accession with AJ488303.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 265 UPDATE SHV-128 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with GU932590.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 264 UPDATE lsaE pleuromutilin; pleuromutilin antibiotic; macrolide antibiotic; lincomycin; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; ARO_description "UPDATED ARO_description with lsaE is an ABC-F subfamily protein found in porcine MRSA isolates. It confers resistance to pleuromutilin, lincosamide, and streptogramin A. " 286 UPDATE SHV-162 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121129.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 269 UPDATE CMY-8 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-8 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA UPDATED fmax with 1761 UPDATED accession with AF167990.3 UPDATED fmin with 612 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAD50818.2 UPDATED sequence with MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG " 4435 UPDATE CARB-51 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4975 UPDATE OXA-655 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4648 UPDATE GOB-35 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4649 UPDATE GOB-36 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4632 UPDATE GOB-19 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4642 UPDATE GOB-29 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4643 UPDATE GOB-30 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4640 UPDATE GOB-27 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4641 UPDATE GOB-28 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4646 UPDATE GOB-33 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2192 UPDATE TriA efflux pump complex or subunit conferring antibiotic resistance; triclosan; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; disinfecting agents and antiseptics; ARO_category "UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 4644 UPDATE GOB-31 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4645 UPDATE GOB-32 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4424 UPDATE CARB-40 penam; antibiotic inactivation; CARB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4630 UPDATE GIL-1 carbapenem; antibiotic inactivation; cephalosporin; GIL beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1294 UPDATE Sed-1 penam; Sed beta-lactamase; cephalosporin; antibiotic inactivation; model_sequences; model_name; ARO_category "UPDATED accession with AF321608.1 UPDATED model_name with Sed-1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4712 UPDATE IMP-89 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2257 UPDATE Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A antibiotic target alteration; elfamycin antibiotic; elfamycin resistant EF-Tu; ARO_description "UPDATED ARO_description with Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A. " 4637 UPDATE GOB-24 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2254 UPDATE Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid antibiotic target alteration; fusidic acid; antibiotic resistant fusA; model_sequences; model_name "UPDATED accession with BX571856.1 UPDATED accession with CAG39573.1 UPDATED model_name with Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid " 2251 UPDATE LpxC peptide antibiotic; antibiotic target alteration; colistin B; colistin A; Acinetobacter mutant Lpx gene conferring resistance to colistin; ARO_description "UPDATED ARO_description with The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. " 4636 UPDATE GOB-23 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5159 UPDATE OXA-862 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5158 UPDATE OXA-861 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 988 UPDATE tet(J) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AF038993.1 " 989 UPDATE ErmG antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED accession with L42817.1 UPDATED category_aro_name with virginiamycin M1 UPDATED category_aro_description with Virginiamycin M1 is a streptogramin A antibiotic. UPDATED category_aro_name with pristinamycin IC UPDATED category_aro_description with Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. UPDATED category_aro_description with Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. " 4635 UPDATE GOB-22 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5151 UPDATE OXA-854 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5150 UPDATE OXA-853 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5153 UPDATE OXA-856 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5152 UPDATE OXA-855 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5155 UPDATE OXA-858 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5154 UPDATE OXA-857 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5157 UPDATE OXA-860 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2478 UPDATE Helicobacter pylori 16S rRNA mutation conferring resistance to tetracycline tetracycline antibiotic; antibiotic target alteration; 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; model_param "UPDATED 12459 with A926G UPDATED 12458 with A928C UPDATED 12459 with A926G UPDATED 12458 with A928C UPDATED 12555 with A926T,G927T,A928C UPDATED 12556 with A926G,G927G,A928C " 115 UPDATE TEM-87 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF250872.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 252 UPDATE APH(9)-Ia antibiotic inactivation; aminoglycoside antibiotic; APH(9); spectinomycin; plazomicin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with APH(9)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in L. pneumophila. UPDATED accession with U94857.1 UPDATED category_aro_description with Phosphorylation of spectinomycin on the hydroxyl group at position 9. " 1790 UPDATE vanHF glycopeptide antibiotic; glycopeptide resistance gene cluster; vanH; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanHF, is a vanH variant in the vanF gene cluster. UPDATED accession with AF155139.1 UPDATED model_name with vanH gene in vanF cluster UPDATED ARO_name with vanH gene in vanF cluster " 116 UPDATE QnrB18 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB18 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with AM919399.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 111 UPDATE Escherichia coli gyrB conferring resistance to aminocoumarin clorobiocin; aminocoumarin antibiotic; novobiocin; coumermycin A1; antibiotic target alteration; aminocoumarin resistant gyrB; ARO_description; model_sequences "UPDATED ARO_description with Point mutation in Escherichia coli resulting in aminocoumarin resistance. UPDATED accession with AP009048.1 " 110 UPDATE AAC(6')-Iu AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Iu is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 17. UPDATED accession with AF031329.1 " 113 UPDATE VEB-5 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF420108.1 UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 112 UPDATE FosA5 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; ARO_description; model_name; ARO_name "UPDATED ARO_description with fosA5 is a fosfomycin resistance gene isolated from clinical strain of Escherichia coli E265. It is susceptible to amikacin, tetracycline and imipenem, and resistant to sulphonamide, cephalosporins, gentamicin, ciprofloxacin, chloramphenicol and streptomycin. UPDATED model_name with fosA5 UPDATED ARO_name with fosA5 " 119 UPDATE VIM-12 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VIM-12 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with DQ143913.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4639 UPDATE GOB-26 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4800 UPDATE ORN-6 carbapenem; ORN beta-lactamase; cephalosporin; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 4801 UPDATE ORR-1 carbapenem; antibiotic inactivation; ORR beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 2787 UPDATE Moraxella catarrhalis M35 penam; reduced permeability to antibiotic; General Bacterial Porin with reduced permeability to beta-lactams; penem; carbapenem; cephalosporin; cephamycin; monobactam; amoxicillin; resistance by absence; model_sequences; ARO_category "UPDATED accession with AY905613.1 UPDATED accession with AAX99225.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). " 4638 UPDATE GOB-25 carbapenem; penam; GOB beta-lactamase; antibiotic inactivation; cephalosporin; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4804 UPDATE OXA-114d carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4805 UPDATE OXA-114e carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4806 UPDATE OXA-114f carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4807 UPDATE OXA-114g carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4808 UPDATE OXA-114h carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4809 UPDATE OXA-114i carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 964 UPDATE OXA-129 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-129 is a beta-lactamase found in Salmonella enterica. UPDATED accession with AM932669.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2789 UPDATE Escherichia coli mipA reduced permeability to antibiotic; nalidixic acid; kanamycin A; MipA-interacting Protein; fluoroquinolone antibiotic; streptomycin; aminoglycoside antibiotic; resistance by absence; model_sequences; model_name; ARO_category "UPDATED accession with NP_310518.1 UPDATED model_name with Escherichia coli mipA UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). " 2788 UPDATE Escherichia coli LamB chlortetracycline; nalidixic acid; balofloxacin; reduced permeability to antibiotic; Sugar Porin (SP); ciprofloxacin; tetracycline antibiotic; fluoroquinolone antibiotic; resistance by absence; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGATGATTACTCTGCGCAAACTTCCTCTGGCGGTTGCCGTCGCAGCGGGCGTAATGTCTGCTCAGGCAATGGCTGTTGATTTCCACGGCTATGCACGTTCCGGTATTGGCTGGACAGGTAGCGGCGGTGAACAACAGTGTTTCCAGACTACCGGTGCTCAAAGTAAATACCGTCTTGGCAACGAATGTGAAACTTATGCTGAATTAAAATTGGGTCAGGAAGTGTGGAAAGAGGGCGATAAGAGCTTCTATTTCGACACTAACGTGGCCTATTCCGTCGCGCAACAGAATGACTGGGAAGCTACCGACCCGGCCTTCCGTGAAGCAAACGTGCAGGGTAAAAACCTGATCGAATGGCTGCCAGGCTCCACCATCTGGGCAGGTAAGCGCTTCTACCAACGTCATGACGTTCATATGATCGACTTCTACTACTGGGATATTTCTGGTCCTGGTGCCGGTCTGGAAAACATCGATGTTGGCTTCGGTAAACTCTCTCTGGCAGCAACCCGCTCCTCTGAAGCAGGTGGTTCTTCCTCTTTCGCCAGCAACAATATTTATGACTATACCAACGAAACCGCGAACGACGTTTTCGATGTGCGTTTAGCGCAGATGGAAGTCAACCCGGGCGGCACATTAGAACTGGGTGTCGACTACGGTCGTGCCAACCTGCGTGATAACTATCGTCTGGTTGATGGCGCATCGAAAGACGGCTGGTTATTCACTGCTGAACATACTCAGAGTGTCCTGAAGGGCTTTAACAAGTTTGTTGTTCAGTACGCTACTGACTCGATGACCTCGCAGGGTAAAGGTCTGTCGCAGGGTTCTGGCGTTGCATTTGATAACGAAAAATTTGCCTACAATATCAACAACAACGGTCACATGCTGCGTATCCTCGACCACGGTGCGATCTCCATGGGCGACAACTGGGACATGATGTACGTGGGTATGTACCAGGATATCAACTGGGATAACGACAACGGCACCAAGTGGTGGACCGTCGGTATTCGCCCGATGTACAAGTGGACGCCAATCATGAGCACCGTGATGGAAATCGGCTACGACAACGTCGAATCCCAGCGCACCGGCGACAAGAACAATCAGTACAAAATTACCCTCGCACAACAATGGCAGGCTGGCGACAGCATCTGGTCACGCCCGGCTATTCGTGTCTTCGCAACCTACGCCAAGTGGGATGAGAAATGGGGTTACGACTACAACGGCGATAGCAAGGTTAACCCGAACTACGGCAAAGCCGTTCCTGCTGATTTCAACGGCGGCAGCTTCGGTCGTGGCGACAGCGACGAGTGGACCTTCGGTGCCCAGATGGAAATCTGGTGGTAA UPDATED fmax with 5102712 UPDATED accession with BA000007.3 UPDATED fmin with 5101371 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli O157:H7 str. Sakai UPDATED NCBI_taxonomy_id with 386585 UPDATED NCBI_taxonomy_cvterm_id with 36747 UPDATED accession with BAB38442.1 UPDATED sequence with MMITLRKLPLAVAVAAGVMSAQAMAVDFHGYARSGIGWTGSGGEQQCFQTTGAQSKYRLGNECETYAELKLGQEVWKEGDKSFYFDTNVAYSVAQQNDWEATDPAFREANVQGKNLIEWLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGLENIDVGFGKLSLAATRSSEAGGSSSFASNNIYDYTNETANDVFDVRLAQMEVNPGGTLELGVDYGRANLRDNYRLVDGASKDGWLFTAEHTQSVLKGFNKFVVQYATDSMTSQGKGLSQGSGVAFDNEKFAYNINNNGHMLRILDHGAISMGDNWDMMYVGMYQDINWDNDNGTKWWTVGIRPMYKWTPIMSTVMEIGYDNVESQRTGDKNNQYKITLAQQWQAGDSIWSRPAIRVFATYAKWDEKWGYDYNGDSKVNPNYGKAVPADFNGGSFGRGDSDEWTFGAQMEIWW UPDATED category_aro_description with Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). " 1797 UPDATE ErmY antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with ErmY is a plasmid-mediated methyltransferase found in Staphylococcus aureus. UPDATED accession with AB014481.1 " 2079 UPDATE sgm kanamycin A; aminoglycoside antibiotic; isepamicin; 16S rRNA methyltransferase (G1405); sisomicin; arbekacin; gentamicin B; netilmicin; antibiotic target alteration; gentamicin C; amikacin; dibekacin; G418; tobramycin; model_sequences "UPDATED accession with NG_050600.1 " 3335 UPDATE qnrE1 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_category "UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1716 UPDATE OXA-398 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087842.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2073 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to G418 antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; G418; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to G418. UPDATED accession with U00096.1 UPDATED NCBI_taxonomy_name with Escherichia coli str. K-12 UPDATED model_name with Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to G418 " 2072 UPDATE NmcR penam; carbapenem; NmcA beta-lactamase; cefazolin; cephalosporin; antibiotic inactivation; cephamycin; amoxicillin; ampicillin; clavulanic acid; cefoxitin; amoxicillin-clavulanic acid; ARO_description; ARO_category "UPDATED ARO_description with NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2071 UPDATE AAC(6')-Ib8 AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description "UPDATED ARO_description with AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. " 2077 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin antibiotic target alteration; aminoglycoside antibiotic; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; ARO_description; model_name "UPDATED ARO_description with Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to neomycin. UPDATED model_name with Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin " 2076 UPDATE Neisseria gonorrhoeae 16S rRNA mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences "UPDATED ARO_description with Point mutations in the helix 34 region of 16S rRNA of Neisseria gonorrhoeae can confer resistance against spectinomycin. UPDATED accession with CP020418.1 " 2075 UPDATE Salmonella enterica soxR with mutation conferring antibiotic resistance antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_description; ARO_category "UPDATED ARO_description with SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression of many multidrug efflux pumps. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 2074 UPDATE Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin antibiotic target alteration; aminoglycoside antibiotic; spectinomycin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_description; model_sequences; model_name "UPDATED ARO_description with Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin. UPDATED accession with AE006468.1 UPDATED model_name with Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin " 4867 UPDATE OXA-532 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4483 UPDATE CRH-3 carbapenem; antibiotic inactivation; CRH beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1796 UPDATE CMY-119 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM087845.1 " 1389 UPDATE KPC-22 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM379100.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3508 UPDATE OXA-438 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3509 UPDATE OXA-439 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Assigned by Lahey's list of beta-lactamases, no accessions or other information available. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1082 UPDATE CTX-M-7 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-7 is a beta-lactamase found in Salmonella typhimurium. UPDATED accession with AJ005045.1 " 5088 UPDATE OXA-780 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5083 UPDATE OXA-774 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5082 UPDATE OXA-773 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5081 UPDATE OXA-772 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5080 UPDATE OXA-771 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5087 UPDATE OXA-778 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3505 UPDATE OXA-432 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5085 UPDATE OXA-776 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5084 UPDATE OXA-775 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 641 UPDATE CARB-6 penam; antibiotic inactivation; CARB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CARB-6 is a beta-lactamase found in Vibrio cholerae. UPDATED accession with AF030945.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2060 UPDATE FosC2 fosfomycin; antibiotic inactivation; fosC phosphotransferase family; ARO_description; model_sequences "UPDATED ARO_description with FosC2 is an enzyme that phosphorylates fosfomycin to confer resistance in Escherichia coli. UPDATED accession with AB522969.1 " 2679 UPDATE MexAB-OprM with MexR mutations confers resistance to multiple antibiotics sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; clavulanic acid; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; amoxicillin-clavulanic acid; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; amoxicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; model_description; ARO_category; model_name "UPDATED model_description with A meta-model used to detect an efflux pump (and its subunits) along with its regulators and any determinants of overexpression (e.g., mutations in efflux pump subunits, mutations in local and global regulators, mutations in two component regulatory systems). UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED model_name with MexAB-OprM with MexR mutations confers resistance to multiple antibiotics " 8 UPDATE NDM-6 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with NDM-6 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with JN967644.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1332 UPDATE APH(3')-IIIa antibiotic inactivation; aminoglycoside antibiotic; plazomicin; paromomycin; kanamycin A; APH(3'); gentamicin B; lividomycin B; lividomycin A; ribostamycin; G418; neomycin; butirosin; model_sequences; ARO_category "UPDATED accession with CP004067.1 UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 2038 UPDATE KPC-17 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences; ARO_category "UPDATED accession with KC465200.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1252 UPDATE ceoB efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; aminoglycoside antibiotic; resistance-nodulation-cell division (RND) antibiotic efflux pump; antibiotic efflux; ARO_description; model_sequences "UPDATED ARO_description with ceoB is a cytoplasmic membrane component of the CeoAB-OpcM efflux pump. UPDATED accession with U97042.1 " 336 UPDATE tlrB conferring tylosin resistance antibiotic target alteration; non-erm 23S ribosomal RNA methyltransferase (G748); macrolide antibiotic; lincosamide antibiotic; model_sequences; ARO_category "UPDATED accession with AF055922.1 UPDATED category_aro_description with Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides. " 1986 UPDATE OXA-309 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HF947514.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1987 UPDATE QnrA1 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrA1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. UPDATED accession with DQ831141.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 3216 UPDATE mphH antibiotic inactivation; macrolide phosphotransferase (MPH); macrolide antibiotic; ARO_description "UPDATED ARO_description with A chromosomal macrolide 2'-phosphotransferase and resistance gene identified from a Brachybacterium faecium cave isolate. " 3217 UPDATE mphK antibiotic inactivation; macrolide phosphotransferase (MPH); macrolide antibiotic; ARO_description "UPDATED ARO_description with A chromosomal macrolide phosphotransferase identified from Bacillus subtilis. " 1982 UPDATE IMP-9 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-9 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED partial with 0 UPDATED sequence with ATGAGCAAGTTATTTGTATTCTTTATGTTTTTGTTTTGTAGCATTACTGCCGCAGGAGAGTCTTTGCCAGATTTAAAAATTGAGAAGCTTGACGAAGGCGTTTATGTTCATACTTCGTTTGAAGAAGTTAACGGTTGGGGTGTTATTCCTAAACACGGCTTGGTGGTTCTTGTAAATACTGATGCCTATCTGATAGACACTCCATTTACTGCTAAAGATACTGAAAATTTAGTTAATTGGTTTGTTGAGCGCGGCTATAGAATAAAAGGCAGTATTTCCTCACATTTCCATAGCGACAGCACGGGTGGAATAGAGTGGCTTAATTCTCAATCTATCCCCACGTATGCATCTGAATTAACAAATGAACTTCTTAAAAAAGACGGTAAGGTACAAGCTAAATATTCATTTAGCGGAGTTAGCTATTGGCTAGTTAAGAAAAAGATTGAAGTTTTTTATCCTGGTCCAGGGCACGCTCCAGATAACGTAGTGGTTTGGCTGCCTGAAAATAGAGTTTTGTTCGGTGGTTGTTTTGTTAAACCCTACGGTCTAGGTAATTTGGGTGACGCAAATTTAGAAGCTTGGCCAAAATCCGCCAAATTATTAATGTCAAAATATAGTAAGGCAAAACTGGTTGTACCAAGTCATAGTGACATAGGAGATTCGTCGCTCTTGAAGCTTACATGGGAGCAGACGGTAAAAGGATTCAATGAAAGCAAAAAAAGTACCACTGCACATTAA UPDATED fmax with 457877 UPDATED accession with KC543497.1 UPDATED fmin with 457139 UPDATED strand with - UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AAK59385.1 UPDATED sequence with MSKLFVFFMFLFCSITAAGESLPDLKIEKLDEGVYVHTSFEEVNGWGVIPKHGLVVLVNTDAYLIDTPFTAKDTENLVNWFVERGYRIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKYSFSGVSYWLVKKKIEVFYPGPGHAPDNVVVWLPENRVLFGGCFVKPYGLGNLGDANLEAWPKSAKLLMSKYSKAKLVVPSHSDIGDSSLLKLTWEQTVKGFNESKKSTTAH UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1983 UPDATE vanTN glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanT; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanTN, is a vanT variant found in the vanN gene cluster. UPDATED accession with JF802084.1 UPDATED model_name with vanT gene in vanN cluster UPDATED ARO_name with vanT gene in vanN cluster " 1980 UPDATE OXA-247 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-247 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with JX893517.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1981 UPDATE vanA glycopeptide resistance gene cluster; Van ligase; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; vancomycin; model_sequences; ARO_category "UPDATED accession with M97297.1 UPDATED category_aro_name with Van ligase UPDATED category_aro_description with Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. " 1638 UPDATE CMY-111 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KJ155695.1 " 1639 UPDATE SHV-84 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AM087453.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3218 UPDATE mphN antibiotic inactivation; macrolide phosphotransferase (MPH); macrolide antibiotic; ARO_description "UPDATED ARO_description with A macrolide phosphotransferase identified on a plasmid in Exiguobacterium. " 3219 UPDATE mphO antibiotic inactivation; macrolide phosphotransferase (MPH); macrolide antibiotic; ARO_description "UPDATED ARO_description with A chromosomal macrolide phosphostransferase identified in Brachybacterium paraconglomeratum. " 1988 UPDATE CMY-7 antibiotic inactivation; CMY beta-lactamase; cephamycin; ARO_description; model_sequences "UPDATED ARO_description with CMY-7 is a beta-lactamase found in Salmonella typhimurium. UPDATED accession with AJ011291.1 " 1989 UPDATE Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; model_sequences; ARO_category "UPDATED accession with CP000647.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_cvterm_id with 43746 UPDATED category_aro_accession with 3005386 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. " 704 UPDATE OprJ penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; trimethoprim; aminocoumarin antibiotic; novobiocin; macrolide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; gentamicin C; chloramphenicol; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; model_sequences; ARO_category "UPDATED accession with U57969.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 587 UPDATE TEM-73 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AJ012256.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4738 UPDATE KPC-79 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2909 UPDATE OXA-664 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; ARO_category "UPDATED ARO_description with Beta-lactamase found in Acinetobacter spp. efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2817 UPDATE Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; ARO_description "UPDATED ARO_description with Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolide type antibiotics. " 2810 UPDATE Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; model_name "UPDATED model_name with Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin " 4965 UPDATE OXA-639 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 560 UPDATE OXA-77 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-77 is a beta-lactamase found in A. baumannii. UPDATED accession with AY949202.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 561 UPDATE OKP-B-8 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-8 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051157.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 562 UPDATE TEM-187 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with TEM-187 is an extended-spectrum beta-lactamase found in P. mirabilis. UPDATED accession with HM246246.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 563 UPDATE OKP-B-6 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-6 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAAGTCAGCTGGCGGGCCGGGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACAGCGCCGGCAATCTGCTGTTGAAGAGCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGTTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTGGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGGGATACCGCAGCGACCATGGCCGAACGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAGCGCTAA UPDATED fmax with 878 UPDATED accession with AM850917.2 UPDATED fmin with 17 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12355.2 UPDATED sequence with MRYVRLCLISLIAALPLAVFASPQPLEQIKISESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAGNLLLKSVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTAATMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 2819 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics antibiotic target alteration; oxazolidinone antibiotic; 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics; ARO_description; ARO_category "UPDATED ARO_description with Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics. UPDATED category_aro_description with Point mutations in the 23S rRNA subunit may confer resistance to oxazolidinone antibiotics. " 2818 UPDATE Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics antibiotic target alteration; 23S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; ARO_description; model_name "UPDATED ARO_description with Point mutation in the 23S rRNA of Streptomyces ambofaciens shown to confer resistance to macrolide type antibiotics. UPDATED model_name with Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics " 566 UPDATE OXA-32 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-32 is a beta-lactamase found in P. aeruginosa. UPDATED accession with AF315351.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 567 UPDATE CTX-M-41 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-41 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with DQ023162.1 " 702 UPDATE CTX-M-98 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-98 is a beta-lactamase found in Escherichia coli. UPDATED accession with HM755448.1 " 5131 UPDATE OXA-829 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5086 UPDATE OXA-777 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 118 UPDATE LRA-9 penam; antibiotic inactivation; subclass B3 LRA beta-lactamase; cephalosporin; ARO_description; ARO_category "UPDATED ARO_description with LRA-9 is a beta-lactamase isolated from soil samples in Alaska. UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2006 UPDATE IMP-27 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; model_sequences; ARO_category "UPDATED accession with JF894248.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3379 UPDATE APH(3')-VIIIa antibiotic inactivation; APH(3'); aminoglycoside antibiotic; G418; neomycin; ARO_category "UPDATED category_aro_description with Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'. " 3378 UPDATE rmtE2 antibiotic target alteration; aminoglycoside antibiotic; 16S rRNA methyltransferase (G1405); ARO_description; model_sequences "UPDATED ARO_description with A 16S rRNA mathyltransferase gene with a single nucleotide mutation compared to rmtE. UPDATED partial with 0 UPDATED sequence with ATGAATATTGATGAAATGGCTGCAGAGGTTCTGTCGAGCAAAAAATATACAAGCGTTGACCCTGCTGTTGTTAGGCGTGTTTGTATGGAAACAGCACCTAAATATCCGAAGAAAAAAGAAGCAATAAAAGCGGTAAAAAATGAACTGCATATCATCCATGAGGTTTTTTTGCAAAACGAATGTTACAAAAATGCGCTTTCATTTTTATCACAGCTATCCTTAGATTTTAATAATGCGCAATTGATCGATATTACTATGCAAATCATGCAATCACATACATCAACCAAAGAGAGATTAGGCGACATTGAAGCGGTTTGTTCATTCTTAAGCACCCATATATCCAAAGAGGGTTCCGTGATGGACATCGGTTGTGGCTTCAATCCATTTGCGTTGCCATTACTGCACGAGTTCCCGGCAACGTATTATGCTTATGATATATGTTCAGAAGGAATTAACATCCTAAACAAATATTTCTCCATCCTAAAAAAAGGAGAATATAGAGCGGAGCTACTTGATGCCGTGTCTGTTACGCCGAAAGAAAAGGTGGATGTTGCCCTCCTATTCAAGCTATTACCTTTGTTGCAGCAACAGAAAAAAGGTCGAGGTTTCAGCATTTTAGAAGAACTGGACTTTGACAAAGCAATTGTATCTTTTCCAATAAAAAGCTTGGGAGGAAAGCAAAAAGGAATGGAAACCTTTTATTCGAATTTGTTTGAAGAAAACCTGCCTTCCTCATTGGAAATCATTGAGAAGCAGACTTTTTCAAATGAGATGTTCTATGTGATACAAAACAAAACCAAAAACGGAGGAAATCAATCATGA UPDATED fmax with 2668 UPDATED accession with KT428293.1 UPDATED fmin with 1846 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ALD03565.1 UPDATED sequence with MNIDEMAAEVLSSKKYTSVDPAVVRRVCMETAPKYPKKKEAIKAVKNELHIIHEVFLQNECYKNALSFLSQLSLDFNNAQLIDITMQIMQSHTSTKERLGDIEAVCSFLSTHISKEGSVMDIGCGFNPFALPLLHEFPATYYAYDICSEGINILNKYFSILKKGEYRAELLDAVSVTPKEKVDVALLFKLLPLLQQQKKGRGFSILEELDFDKAIVSFPIKSLGGKQKGMETFYSNLFEENLPSSLEIIEKQTFSNEMFYVIQNKTKNGGNQS " 5068 UPDATE OXA-759 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 726 UPDATE PC1 beta-lactamase (blaZ) penam; antibiotic inactivation; BlaZ beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with BlaZ beta-lactamase UPDATED category_aro_description with BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus. " 2036 UPDATE SHV-163 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with JX121130.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 724 UPDATE AAC(6')-Ij AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ij is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 13. UPDATED accession with L29045.1 " 1026 UPDATE SHV-74 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGACGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 891 UPDATED accession with AM176549.2 UPDATED fmin with 30 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAJ47129.2 UPDATED sequence with MRYIRLCIISLLATLPLTVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1748 UPDATE lsaC pleuromutilin; pleuromutilin antibiotic; macrolide antibiotic; lincomycin; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; clindamycin; phenicol antibiotic; lincosamide antibiotic; ARO_description; model_sequences "UPDATED ARO_description with LsaC is an ABC-F subfamily protein expressed in Streptococcus agalactiae. It confers resistance to lincomycin, clindamycin, dalfopristin, and tiamulin. UPDATED accession with HM990671.1 " 1749 UPDATE IMP-18 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-18 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with JN596991.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 720 UPDATE BcI penam; antibiotic inactivation; cephalosporin; Bc beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with Bacillus cereus beta-lactamase I is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9. UPDATED accession with X06599.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5635 UPDATE PSV-1 carbapenem; antibiotic inactivation; cephalosporin; PSV beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 1744 UPDATE cmrA antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences "UPDATED ARO_description with cmrA is a transposon-encoded chloramphenicol exporter that is found in Rhodococcus rhodochrous. UPDATED accession with AF015087.1 " 1487 UPDATE SHV-48 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY263404.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1746 UPDATE IMP-24 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-24 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with EF192154.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1747 UPDATE CMY-103 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KF526116.1 " 1740 UPDATE TEM-53 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF104441.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1741 UPDATE OXA-359 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF421162.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1742 UPDATE SHV-28 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF299299.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1486 UPDATE CARB-12 penam; antibiotic inactivation; CARB beta-lactamase; model_sequences; ARO_category "UPDATED accession with D13210.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1164 UPDATE MIR-9 antibiotic inactivation; monobactam; cephalosporin; MIR beta-lactamase; model_sequences; ARO_category "UPDATED accession with KM087860.1 UPDATED category_aro_description with MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. " 1165 UPDATE OKP-A-4 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-A-4 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED accession with AM051142.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 4393 UPDATE BlaB-31 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1160 UPDATE QnrB34 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB34 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. UPDATED accession with JN173056.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 2035 UPDATE CTX-M-15 penam; antibiotic inactivation; cephalosporin; cefazolin; ceftazidime; cefalotin; ampicillin; ceftriaxone; CTX-M beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family. UPDATED accession with AY044436.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4397 UPDATE BlaB-35 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3304 UPDATE erm(40) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; model_sequences "UPDATED partial with 0 UPDATED sequence with GTGTCATCCAAAAATCAAGGCCGGCATGAGCACGGCCAGAATTTTCTGTGCGACCGTCGCGTGGTCGCCGACATCGTCAAAATCGTCTCGCACACAACAGGTTCCATCGTCGAGATCGGCGCCGGAGACGGTGCGCTGACCGTCCCGATGCAGCGGCTCGGGCGGCCGTTGACGGCCATCGAGATCGACCGTCGACGAGCAGAGCGCCTGGCTCGCCGTACCACGGCGCATGTCGTCACCGCCGATTTCCTGCGCTACCGCCTGCCACCCACCGAGCACGTGGTGGTGGGCAACCTGCCGTTCCACCTGACCACCGCGATTTTGCGGCGGCTGCTGCACAGCCCGGCATGGACCGACGCGGTGCTGCTCATGCAGTGGGAGGTGGCGCGCCGCCGCGCCGCGGTCGGCGGCGCAACGATGATGACCGCGCAGTGGTGGCCGTGGTTCGAATTCGGCTTGGCCCGTAAGGTTTCCGCCGACGCGTTCCGTCCCCGCCCGAGCGTGGACGCCGGGTTGCTGACCATCACGCGGCGCCGGGAACCGCTGATCGACGGCGCCGACCGCCGGCGCTACCAGGCGCTGGTCCATGCAGTGTTCACCGGGCGCGGCCGCGGTGTGGCGCAGATTGTGGGTCCACGAGTCCCGCGGCACTGGTTGCGCCACAACGGCATCACACCGTCGGCGCTGCCGAGGGATCTCACGGCCGCGCAGTGGGCAGCTCTGTTCGAGGTGACGAGCGAGGCGAAGCGGTGCTAG UPDATED fmax with 2790 UPDATED accession with AY570506.1 UPDATED fmin with 2034 UPDATED strand with + UPDATED NCBI_taxonomy_name with Mycolicibacterium mageritense UPDATED NCBI_taxonomy_id with 53462 UPDATED NCBI_taxonomy_cvterm_id with 42568 UPDATED accession with AAS76623.1 UPDATED sequence with MSSKNQGRHEHGQNFLCDRRVVADIVKIVSHTTGSIVEIGAGDGALTVPMQRLGRPLTAIEIDRRRAERLARRTTAHVVTADFLRYRLPPTEHVVVGNLPFHLTTAILRRLLHSPAWTDAVLLMQWEVARRRAAVGGATMMTAQWWPWFEFGLARKVSADAFRPRPSVDAGLLTITRRREPLIDGADRRRYQALVHAVFTGRGRGVAQIVGPRVPRHWLRHNGITPSALPRDLTAAQWAALFEVTSEAKRC " 749 UPDATE SHV-97 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences; ARO_category "UPDATED accession with EF373973.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4962 UPDATE OXA-636 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3305 UPDATE EreD antibiotic inactivation; macrolide antibiotic; macrolide esterase; ARO_description "UPDATED ARO_description with EreD is an erythromycin esterase protein. " 48 UPDATE OXA-90 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-90 is a beta-lactamase found in A. baumannii. UPDATED accession with AM231719.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 49 UPDATE tsnR peptide antibiotic; antibiotic target alteration; thiostrepton; non-erm 23S ribosomal RNA methyltransferase (A1067); ARO_description; ARO_category "UPDATED ARO_description with tsnR is a 23S ribosomal RNA methyltransferase that methylates adenosine-1067 to confer resistance to thiostrepton. UPDATED category_aro_description with Non-erm 23S ribosomal RNA methyltransferases modify adenosine 1067 to confer resistance to peptide antibiotics. " 46 UPDATE CMY-114 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED accession with KM087846.1 " 44 UPDATE golS penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; penem; carbapenem; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cephamycin; monobactam; phenicol antibiotic; chloramphenicol; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 42 UPDATE OXY-6-1 penam; OXY beta-lactamase; cephalosporin; antibiotic inactivation; monobactam; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXY-6-1 is a beta-lactamase found in Klebsiella oxytoca. UPDATED accession with AJ871874.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2034 UPDATE TEM-108 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AF506748.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 40 UPDATE QnrB58 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB58 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with JX259319.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1568 UPDATE OXA-183 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with HQ111474.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1299 UPDATE AAC(6')-Ic AAC(6'); antibiotic inactivation; aminoglycoside antibiotic; ARO_description; model_sequences "UPDATED ARO_description with AAC(6')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in S. marcescens. UPDATED accession with M94066.1 " 5020 UPDATE OXA-708 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1560 UPDATE OKP-B-20 penam; antibiotic inactivation; OKP beta-lactamase; cephalosporin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OKP-B-20 is a beta-lactamase found in Klebsiella pneumoniae. UPDATED partial with 0 UPDATED sequence with ATGCGTTATGTTCGCCTGTGCCTTATCTCCCTGATTGCCGCCCTGCCACTGGCGGTATTCGCCAGCCCTCAGCCGCTTGAGCAGATTAAAATCAGCGAAAGTCAGCTGGCGGGCCGTGTGGGCTATGTTGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCAGTGAGCGCTTTCCGCTGATGAGCACCTTTAAAGTGCTGCTCTGCGGCGCGGTGCTGGCCCGGGTGGATGCCGGCGACGAACAGCTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGCCGACGGGATGACCGTTGGCGAACTCTGCGCCGCCGCCATCACCATGAGCGACAACACCGCCGGCAATCTGCTGTTGAAGATCGTCGGCGGCCCCGCGGGATTGACCGCTTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGAACTCAATGAGGCGCTTCCCGGCGACGTGCGCGACACCACCACCCCGGCCAGCATGGCCACCACCCTGCGCAAGCTGCTAACCACCCCCTCTCTGAGCGCCCGTTCGCAGCAGCAGCTGCTGCAGTGGATGGTTGACGACCGGGTGGCCGGCCCGTTGATCCGCGCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAAACCGGGGCCGGTGAGCGGGGCTCACGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAAGCGGAGCGTATCGTGGTGATCTATCTGCGTGATACCGCGGCGACCATGGTCGAGCGTAACCAGCAGATCGCCGGGATAGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 885 UPDATED accession with AM850922.2 UPDATED fmin with 24 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with CAP12360.2 UPDATED sequence with MRYVRLCLISLIAALPLAVFASPQPLEQIKISESQLAGRVGYVEMDLASGRTLAAWRASERFPLMSTFKVLLCGAVLARVDAGDEQLDRRIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNTAGNLLLKIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDVRDTTTPASMATTLRKLLTTPSLSARSQQQLLQWMVDDRVAGPLIRAVLPAGWFIADKTGAGERGSRGIVALLGPDGKAERIVVIYLRDTAATMVERNQQIAGIGAALIEHWQR UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_description with OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. " 1561 UPDATE vanTG glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vanT; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanTG, is a vanT variant found in the vanG gene cluster. UPDATED accession with DQ212986.1 UPDATED model_name with vanT gene in vanG cluster UPDATED ARO_name with vanT gene in vanG cluster " 1562 UPDATE aad(6) antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); ARO_description; model_sequences; ARO_category "UPDATED ARO_description with ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis. UPDATED accession with AY712687.1 UPDATED category_aro_description with Nucelotidylylation of streptomycin at the hydroxyl group at position 6. " 1563 UPDATE CTX-M-63 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-63 is a beta-lactamase found in Salmonella enterica. UPDATED accession with AB205197.1 " 1564 UPDATE QnrB16 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with QnrB16 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. UPDATED accession with EU136183.1 UPDATED category_aro_description with Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. " 1565 UPDATE ACT-18 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences; ARO_category "UPDATED accession with KF992028.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1566 UPDATE vanXD glycopeptide antibiotic; glycopeptide resistance gene cluster; vanX; antibiotic target alteration; ARO_description; model_sequences; model_name; ARO_name "UPDATED ARO_description with Also known as vanXD, is a vanX variant found in the vanD gene cluster. UPDATED accession with AY082011.1 UPDATED model_name with vanX gene in vanD cluster UPDATED ARO_name with vanX gene in vanD cluster " 2135 UPDATE ACT-33 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5022 UPDATE OXA-710 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1360 UPDATE Bartonella bacilliformis gyrB conferring resistance to aminocoumarin clorobiocin; aminocoumarin antibiotic; novobiocin; coumermycin A1; antibiotic target alteration; aminocoumarin resistant gyrB; ARO_description "UPDATED ARO_description with Point mutation in Bartonella bacilliformis resulting in aminocoumarin resistance. " 4693 UPDATE IMP-66 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 591 UPDATE CTX-M-122 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED accession with JN790863.1 " 2033 UPDATE mtrR penam; antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; linoleic acid; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibacterial free fatty acids; penicillin; palmitic acid; oleic acid; azithromycin; erythromycin; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4931 UPDATE OXA-605 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 795 UPDATE OXA-324 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences; ARO_category "UPDATED accession with KF203098.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1381 UPDATE CcrA carbapenem; antibiotic inactivation; CfiA beta-lactamase; model_sequences; model_name "UPDATED accession with M63556.1 UPDATED model_name with CcrA " 613 UPDATE VEB-4 antibiotic inactivation; monobactam; cephalosporin; VEB beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with VEB-4 is a beta-lactamase found in Proteus mirabilis. UPDATED accession with EF136375.1 UPDATED category_aro_description with VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. " 458 UPDATE tet(B) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_sequences "UPDATED accession with AB089595.1 " 4960 UPDATE OXA-634 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5125 UPDATE OXA-822 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4398 UPDATE BlaB-36 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; model_sequences; ARO_category "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2032 UPDATE CTX-M-62 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; ARO_description; model_sequences "UPDATED ARO_description with CTX-M-62 is a beta-lactamase found in Escherichia coli. UPDATED partial with 0 UPDATED sequence with ATGGTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGAAGACTGGGGGTGGCATTGATTAACACAGCGGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTCGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTGGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGTCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCAGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGACTATGGCACCACCAACGATATCGCGGTGATTTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA UPDATED fmax with 3001 UPDATED accession with EF219134.3 UPDATED fmin with 2125 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with ABP04245.1 UPDATED sequence with MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTESTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL " 4392 UPDATE BlaB-30 carbapenem; penam; antibiotic inactivation; BlaB beta-lactamase; ARO_category "UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5637 UPDATE RAHN-2 antibiotic inactivation; cephalosporin; RAHN beta-lactamase; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 5632 UPDATE POM-2 carbapenem; POM beta-lactamase; antibiotic inactivation; model_sequences "UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance " 472 UPDATE TEM-128 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with AY368237.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 473 UPDATE mphF antibiotic inactivation; macrolide phosphotransferase (MPH); macrolide antibiotic; ARO_description "UPDATED ARO_description with mphF is a macrolide phosphotransferase and resistance gene identified on the IncP plasmid pRSB111. " 470 UPDATE OXA-4 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-4 is a beta-lactamase found in Enterobacteriaceae and P. aeruginosa. UPDATED accession with JN129451.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 471 UPDATE TEM-151 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; ARO_category "UPDATED accession with DQ834729.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 477 UPDATE catP antibiotic inactivation; thiamphenicol; chloramphenicol acetyltransferase (CAT); azidamfenicol; phenicol antibiotic; chloramphenicol; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with catP is a transposon and chromosome-encoded variant of the cat gene found in Clostridium perfringens and Neisseria meningitidis. UPDATED accession with U15027.1 UPDATED category_aro_description with Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. " 1446 UPDATE PDC-6 PDC beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; carbapenem; model_sequences "UPDATED accession with FJ666069.1 " 475 UPDATE OXA-106 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with OXA-106 is a beta-lactamase found in A. baumannii. UPDATED accession with EF650032.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4444 UPDATE CepA-49 CepA beta-lactamase; antibiotic inactivation; cephalosporin; ARO_category "UPDATED category_aro_name with CepA beta-lactamase UPDATED category_aro_description with CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin. " 479 UPDATE IMP-29 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; ARO_description; model_sequences; ARO_category "UPDATED ARO_description with IMP-29 is a beta-lactamase found in Pseudomonas aeruginosa. UPDATED accession with JQ041634.1 UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1368 UPDATE abeM antibiotic efflux; triclosan; ofloxacin; norfloxacin; multidrug and toxic compound extrusion (MATE) transporter; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and antiseptics; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with GTGTCGAATGTCACGTCGTTTCGGTCTGAATTAAAACAACTCTTCCATTTAATGTTACCTATTTTAATTACGCAGTTTGCTCAAGCAGGGTTCGGGTTAATTGATACCATTATGGCTGGGCATTTATCTGCCGCAGACTTAGCCGCTATTGCGGTAGGTGTAGGCTTATGGATTCCAGTCATGCTCTTGTTCAGTGGCATCATGATTGCAACCACACCATTAGTTGCCGAAGCAAAAGGCGCTAGAAATACAGAGCAAATTCCAGTGATTGTCCGCCAATCATTATGGGTTGCAGTAATTCTAGGGGTATTGGCAATGCTCATTTTGCAGCTTATGCCATTTTTCTTACATGTGTTTGGCGTACCAGAAAGTTTACAACCTAAAGCCAGTTTATTCTTACATGCAATTGGTTTGGGTATGCCCGCTGTAACCATGTATGCAGCGCTCCGAGGCTATTCCGAAGCATTAGGCCATCCCCGCCCTGTCACGGTCATTAGCTTACTAGCCTTAGTGGTTTTAATCCCGCTTAACATGATTTTTATGTATGGCTTAGGACCAATACCTGCTTTGGGTAGCGCAGGCTGTGGTTTTGCAACATCCATTTTACAGTGGCTGATGCTCATTACGTTAGCAGGCTATATTTATAAGGCTTCGGCTTATCGAAACACATCTATTTTTAGCAGATTCGATAAAATTAGCCTGACTTGGGTTAAAAGAATTTTACAGCTCGGCCTGCCAATTGGTTTAGCTGTGTTTTTTGAAGTGAGTATTTTTAGTACAGGGGCATTGGTCCTTAGCCCTCTAGGGGAAGTCTTTATTGCCGCACACCAAGTAGCAATTTCAGTCACTTCGGTACTGTTTATGATTCCACTTTCTCTTGCCATTGCTTTAACCATTCGCGTGGGGACGTATTATGGTGAAAAGAACTGGGCTTCCATGTACCAAGTACAGAAAATTGGTCTAAGCACAGCAGTATTTTTTGCTCTATTGACCATGTCTTTTATTGCTTTAGGCCGTGAACAAATTGTCTCGGTTTATACTCAAGATATAAATGTTGTGCCGGTTGCCATGTATTTGCTCTGGTTTGCAATGGCATATCAATTAATGGATGCTCTACAAGTCAGCGCTGCCGGCTGTTTAAGAGGTATGCAAGATACTCAGGCACCGATGTGGATCACCTTAATGGCGTATTGGGTAATTGCTTTTCCAATCGGTCTTTATTTAGCGCGTTATACCGATTGGGGCGTAGCTGGTGTGTGGTTAGGTTTAATTATTGGTTTAAGTATTGCCTGTGTTTTATTGCTATCACGACTCTATTTGAATACCAAACGTTTAAGTCAAACCTAA UPDATED fmax with 1533 UPDATED accession with AB204810.2 UPDATED fmin with 186 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter baumannii UPDATED NCBI_taxonomy_id with 470 UPDATED NCBI_taxonomy_cvterm_id with 35507 UPDATED accession with BAD89844.2 UPDATED sequence with MSNVTSFRSELKQLFHLMLPILITQFAQAGFGLIDTIMAGHLSAADLAAIAVGVGLWIPVMLLFSGIMIATTPLVAEAKGARNTEQIPVIVRQSLWVAVILGVLAMLILQLMPFFLHVFGVPESLQPKASLFLHAIGLGMPAVTMYAALRGYSEALGHPRPVTVISLLALVVLIPLNMIFMYGLGPIPALGSAGCGFATSILQWLMLITLAGYIYKASAYRNTSIFSRFDKISLTWVKRILQLGLPIGLAVFFEVSIFSTGALVLSPLGEVFIAAHQVAISVTSVLFMIPLSLAIALTIRVGTYYGEKNWASMYQVQKIGLSTAVFFALLTMSFIALGREQIVSVYTQDINVVPVAMYLLWFAMAYQLMDALQVSAAGCLRGMQDTQAPMWITLMAYWVIAFPIGLYLARYTDWGVAGVWLGLIIGLSIACVLLLSRLYLNTKRLSQT UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_name with disinfecting agents and antiseptics UPDATED category_aro_description with Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. DELETED 36193 " 3704 DELETE Neisseria gonorrhoeae rpld antibiotic target alteration; 50S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; azithromycin; N/A N/A 5733 ADD fexB efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; florfenicol; antibiotic efflux; N/A N/A 5740 ADD salE retapamulin; pleuromutilin antibiotic; tiamulin; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; N/A N/A 5742 ADD Erm(52) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; N/A N/A 5743 ADD msr(G) pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; N/A N/A 5744 ADD msr(I) pleuromutilin antibiotic; macrolide antibiotic; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; N/A N/A 5745 ADD mefF efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; macrolide antibiotic; antibiotic efflux; N/A N/A 5746 ADD Erm(51) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; N/A N/A 5747 ADD mefH efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; macrolide antibiotic; antibiotic efflux; N/A N/A 5748 ADD mefJ efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; macrolide antibiotic; antibiotic efflux; N/A N/A 5749 ADD mreA efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; macrolide antibiotic; antibiotic efflux; N/A N/A 5762 ADD Erm(50) antibiotic target alteration; streptogramin antibiotic; Erm 23S ribosomal RNA methyltransferase; macrolide antibiotic; lincosamide antibiotic; N/A N/A 5763 ADD Neisseria gonorrhoeae rpld antibiotic target alteration; 50S rRNA with mutation conferring resistance to macrolide antibiotics; macrolide antibiotic; azithromycin; N/A N/A 5760 ADD hp1165 tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; N/A N/A 5761 ADD VAM-1 penam; carbapenem; VAM beta-lactamase; cefotaxime; tetracycline antibiotic; cephalosporin; antibiotic inactivation; amoxicillin-clavulanic acid; amoxicillin; ampicillin; clavulanic acid; ceftriaxone; tetracycline; N/A N/A 3453 ADD OXA-289 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 5728 ADD sepA efflux pump complex or subunit conferring antibiotic resistance; small multidrug resistance (SMR) antibiotic efflux pump; disinfecting agents and antiseptics; antibiotic efflux; N/A N/A 5729 ADD sdrM antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; disinfecting agents and antiseptics; N/A N/A 5726 ADD norC antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; ciprofloxacin; fluoroquinolone antibiotic; disinfecting agents and antiseptics; N/A N/A 5727 ADD mdeA penam; antibiotic efflux; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline antibiotic; nalidixic acid; kanamycin A; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; oxacillin; ciprofloxacin; ampicillin; fluoroquinolone antibiotic; aminoglycoside antibiotic; disinfecting agents and antiseptics; tetracycline; N/A N/A 5753 ADD Helicobacter pylori gyrB conferring resistance to fluoroquinolones antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrB; N/A N/A 5752 ADD Helicobacter pylori gyrA conferring resistance to fluoroquinolones levofloxacin; antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrA; N/A N/A 5737 ADD salB retapamulin; virginiamycin M1; pleuromutilin antibiotic; tiamulin; macrolide antibiotic; lincomycin; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; clindamycin; phenicol antibiotic; lincosamide antibiotic; N/A N/A 5736 ADD NDM-33 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; NDM beta-lactamase; ciprofloxacin; cephamycin; fluoroquinolone antibiotic; N/A N/A 5731 ADD qacG efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; small multidrug resistance (SMR) antibiotic efflux pump; disinfecting agents and antiseptics; benzalkonium chloride; N/A N/A 5756 ADD Helicobacter pylori pbp3 conferring resistance to amoxicillin penam; cephamycin; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; amoxicillin; N/A N/A 5755 ADD Helicobacter pylori rdxA mutation conferring resistance to metronidazole nitroimidazole antibiotic; Antibiotic resistant Helicobacter pylori nitroreductase; antibiotic target alteration; metronidazole; N/A N/A 5732 ADD SHD-1 carbapenem; antibiotic inactivation; cephalosporin; SHD beta-lactamase; N/A N/A 5759 ADD Helicobacter pylori frxA mutation conferring resistance to metronidazole nitroimidazole antibiotic; Antibiotic resistant Helicobacter pylori nitroreductase; antibiotic target alteration; metronidazole; N/A N/A 5758 ADD Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin penam; cephamycin; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; amoxicillin; N/A N/A 5739 ADD salD retapamulin; virginiamycin M1; pleuromutilin antibiotic; tiamulin; macrolide antibiotic; lincomycin; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; phenicol antibiotic; lincosamide antibiotic; N/A N/A 5738 ADD salC retapamulin; virginiamycin M1; pleuromutilin antibiotic; tiamulin; macrolide antibiotic; lincomycin; ABC-F ATP-binding cassette ribosomal protection protein; antibiotic target protection; oxazolidinone antibiotic; tetracycline antibiotic; streptogramin antibiotic; clindamycin; phenicol antibiotic; lincosamide antibiotic; N/A N/A 5734 ADD BioF PFM-like beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 5751 ADD OXA-290 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; N/A N/A 5750 ADD Helicobacter pylori rpoB mutation conferring resistance to rifampicin antibiotic target alteration; antibiotic target replacement; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifamycin antibiotic; N/A N/A 5757 ADD Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin penam; cephamycin; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; amoxicillin; N/A N/A 5730 ADD qacJ efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; small multidrug resistance (SMR) antibiotic efflux pump; disinfecting agents and antiseptics; benzalkonium chloride; N/A N/A