{"$update": {"1144": {"$update": {"ARO_category": {"$insert": {"35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1262": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"915": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "127": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "621": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "5740": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "45589": {"category_aro_name": "sal-type ABC-F protein", "category_aro_cvterm_id": "45589", "category_aro_accession": "3007030", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection."}}}}}, "5743": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "36189", "36218", "36526", "35936"], "$insert": {"41695": {"category_aro_name": "msr-type ABC-F protein", "category_aro_cvterm_id": "41695", "category_aro_accession": "3004471", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms."}}}}}, "5744": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "36189", "36218", "36526", "35936"], "$insert": {"41695": {"category_aro_name": "msr-type ABC-F protein", "category_aro_cvterm_id": "41695", "category_aro_accession": "3004471", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms."}}}}}, "200": {"$update": {"model_sequences": {"$update": {"sequence": {"8427": {"dna_sequence": {"partial": "1", "sequence": "TCCCTGTTAGCCACCCTGCCACTGGCGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCGGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACTGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGG", "fmax": "458", "accession": "AY265889.1", "fmin": "2", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550", "NCBI_taxonomy_cvterm_id": "36884"}, "protein_sequence": {"accession": "AAP93847.1", "sequence": "SLLATLPLAVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTIGELCAAAITLSDNCAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRW"}}}}}}}, "1774": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1271": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "2526": {"$update": {"ARO_category": {"$insert": {"35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "696": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "2523": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "698": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1957": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1075": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1800": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1549": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "280": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1588": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "2013": {"$update": {"model_sequences": {"$update": {"sequence": {"8379": {"dna_sequence": {"partial": "0", "sequence": "GTGGATCTGGGCGCAGGACACGGCGCGCTGACGGCACATCTGGTTGCCGCTGGCGCCAGGGTGCTAGCCGTCGAGCTGCATCCGGGGCGGGCTCGACACCTTCGTTCACGGTTTGCCGAGGAAGATGTCCGGGTAGCGGAAGCGGACCTACTCGCCTTCCGGTGGCCGCGACGGCCATTTCGGGTGGTGGCGAGCCCGCCCTACCAAGTCACCAGCGCACTGATCCGGAGTCTCTTGACGCCGGAATCCCGGCTGCTGGCTGCCGACCTGGTGCTGCAGCGCGGGGCTGTGCACAAACATGCGAAGCGAGCACCTGTTCGCCATTGGACGCTACGGGCCGGAATCACATTGCCGCGAAGCGCTTTCCATCATCCACCGCAGGTGGATTCGTCGGTGCTGGTGATCAGGCGGCGCTGA", "fmax": "3469", "accession": "EU177504.3", "fmin": "3052", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacteroides abscessus", "NCBI_taxonomy_id": "36809", "NCBI_taxonomy_cvterm_id": "36888"}, "protein_sequence": {"accession": "ABW06859.1", "sequence": "MDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSRFAEEDVRVAEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHPPQVDSSVLVIRRR"}}}}}, "ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "286": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"830": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "3760": {"$update": {"model_sequences": {"$update": {"sequence": {"8391": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACATTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGGCAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCTCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "fmax": "21380", "accession": "QCWX01000028.1", "fmin": "20234", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Citrobacter freundii", "NCBI_taxonomy_id": "546", "NCBI_taxonomy_cvterm_id": "36915"}, "protein_sequence": {"accession": "PUU64961.1", "sequence": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKHSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASLVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ"}}}}}}}, "1097": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1090": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1075": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1158": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1474": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1156": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "3484": {"$update": {"ARO_category": {"$delete": ["35919", "41687", "35945", "36189", "36218", "36526", "35936"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}}}}}, "1319": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2021": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "3400": {"$update": {"ARO_category": {"$delete": ["37018", "37716", "37013", "37016", "37017", "41687", "35919", "36189", "36218", "36526", "35936"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "36252": {"category_aro_name": "vga-type ABC-F protein", "category_aro_cvterm_id": "36252", "category_aro_accession": "3000113", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection."}}}}}, "5751": {"$update": {"model_sequences": {"$update": {"sequence": {"8401": {"dna_sequence": {"partial": "0", "sequence": "ATGATTGGACTGACGTTGCTAGGTTGCCAAAATTTGCACGCCCCAACTCAAAGCGCCGTGTCAAAAAAACACGATCAAACCGAGATCGCTTCTTTATTCCAACATACTCAAACTGTTGGCGTATTTGTTACATATGATGGGCAAACATTTCAAGAATATGGCAATGCGTTGAGTCGATCGAATACGGCTTATATTCCAGCCTCAACCTTCAAGATGTTAAATGCTCTGATTGGGATACAGCATCACAAAAGTTCGCCCAACGAAGTGTTTAAATGGGATGGCAAAAAGCGTGCTTTTGCGAGCTGGGAAAAAGATTTAACTTTAGCCGAGGCGATGCAGGCATCAGCAGTGCCTGTTTATCAGGAATTGGCTCGGCGTATCGGGTTAGAGTTGATGGCGAACGAAGTAAAACGCGTTGGCTTTGGCAATACTGAGATCGGAACGCAAGTCGATGATTTTTGGTTGGTTGGCCCGCTTAAGATTACCCCCGTTGACGAAGTGAAATTTGCTTATGCTCTGGCAAATAAGCAGCTTGCATTTGACCAATCTGTGCAAGAACAAGTGAAACAGATGGTCTTCGTTGATGAAGTTCATGGAACTAAGATTTATGCCAAAAGTGGTTGGGGTATGGATGTAACACCGCAAGTGGGTTGGTGGACGGGCTGGATTGAACAACCGAATGGACAGGTGATTGCATTTGCTTTAAATCTGGAAATAAATAAGCCTGAGCACGGTGATGCGCGTAAAGCGATTGTTTATCAAGCATTACAACAATTGAAATTGTTACAGAAGCAATAA", "fmax": "290736", "accession": "APOK01000044.1", "fmin": "289938", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter sp. CIP-A165", "NCBI_taxonomy_id": "40373", "NCBI_taxonomy_cvterm_id": "39511"}, "protein_sequence": {"accession": "ENU29139.1", "sequence": "MIGLTLLGCQNLHAPTQSAVSKKHDQTEIASLFQHTQTVGVFVTYDGQTFQEYGNALSRSNTAYIPASTFKMLNALIGIQHHKSSPNEVFKWDGKKRAFASWEKDLTLAEAMQASAVPVYQELARRIGLELMANEVKRVGFGNTEIGTQVDDFWLVGPLKITPVDEVKFAYALANKQLAFDQSVQEQVKQMVFVDEVHGTKIYAKSGWGMDVTPQVGWWTGWIEQPNGQVIAFALNLEINKPEHGDARKAIVYQALQQLKLLQKQ"}}}}}}}, "260": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1953": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1472": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "3406": {"$update": {"model_sequences": {"$update": {"sequence": {"8421": {"dna_sequence": {"partial": "1", "sequence": "TTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGCATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGATAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATAT", "fmax": "706", "accession": "KR780479.1", "fmin": "1", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae subsp. pneumoniae", "NCBI_taxonomy_id": "72407", "NCBI_taxonomy_cvterm_id": "39097"}, "protein_sequence": {"accession": "ALL27283.1", "sequence": "FAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKY"}}}}}}}, "128": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "35945", "36189", "36218", "36526", "35936"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}}}}}, "1701": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "916": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1842": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1829": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1284": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "56": {"$update": {"model_sequences": {"$update": {"sequence": {"8424": {"dna_sequence": {"partial": "1", "sequence": "TTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATAAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATAGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGA", "fmax": "783", "accession": "AF527798.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AAO33760.1", "sequence": "FFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNR"}}}}}}}, "1066": {"$update": {"model_sequences": {"$update": {"sequence": {"8422": {"dna_sequence": {"partial": "1", "sequence": "TTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCATTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACATGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGA", "fmax": "783", "accession": "AY130285.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella oxytoca", "NCBI_taxonomy_id": "571", "NCBI_taxonomy_cvterm_id": "36788"}, "protein_sequence": {"accession": "AAN05029.1", "sequence": "FFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNR"}}}}}}}, "928": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "35945", "36189", "36218", "36526", "35936"], "$insert": {"37627": {"category_aro_name": "carbomycin", "category_aro_cvterm_id": "37627", "category_aro_accession": "3001228", "category_aro_class_name": "Antibiotic", "category_aro_description": "Produced by Streptomyces halstedii and Streptomyces thermotolerans."}, "45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}}}}}, "1388": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "35945", "36189", "36218", "36526", "35936"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}}}}}, "3847": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"41696": {"category_aro_name": "lsa-type ABC-F protein", "category_aro_cvterm_id": "41696", "category_aro_accession": "3004472", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome."}}}}}, "825": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1314": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1412": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1146": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "2265": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "45589": {"category_aro_name": "sal-type ABC-F protein", "category_aro_cvterm_id": "45589", "category_aro_accession": "3007030", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection."}}}}}, "374": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1391": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "290": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "989": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "2907": {"$update": {"ARO_category": {"$delete": ["37014", "35919", "41687", "36189", "36218", "36526"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "3822": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "36189", "36218", "36526", "35936"], "$insert": {"41695": {"category_aro_name": "msr-type ABC-F protein", "category_aro_cvterm_id": "41695", "category_aro_accession": "3004471", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms."}}}}}, "3821": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "36189", "36218", "36526", "35936"], "$insert": {"41695": {"category_aro_name": "msr-type ABC-F protein", "category_aro_cvterm_id": "41695", "category_aro_accession": "3004471", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms."}}}}}, "1080": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1712": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "3944": {"$update": {"model_sequences": {"$update": {"sequence": {"8393": {"dna_sequence": {"partial": "0", "sequence": "ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGAACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACTTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA", "fmax": "3203", "accession": "LLMY01000078.1", "fmin": "2375", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "OPD39420.1", "sequence": "MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKILHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR"}}}}}}}, "190": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2003": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "985": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "271": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1179": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "279": {"$update": {"model_sequences": {"$update": {"sequence": {"8431": {"dna_sequence": {"partial": "1", "sequence": "GTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAGAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACC", "fmax": "863", "accession": "JF274244.1", "fmin": "2", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella sp. SH219", "NCBI_taxonomy_id": "1074433", "NCBI_taxonomy_cvterm_id": "39656"}, "protein_sequence": {"accession": "AEM44650.1", "sequence": "VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDRTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT"}}}}}}}, "2826": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1488": {"$update": {"model_sequences": {"$update": {"sequence": {"8423": {"dna_sequence": {"partial": "1", "sequence": "TTTTTTGCGGCATTTTGCTTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCATTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACATGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGA", "fmax": "783", "accession": "AY130284.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAN05028.1", "sequence": "FFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNR"}}}}}}}, "3300": {"$update": {"ARO_category": {"$insert": {"35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}, "35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "4046": {"$update": {"model_sequences": {"$update": {"sequence": {"8397": {"dna_sequence": {"partial": "0", "sequence": "ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGCACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACCTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA", "fmax": "946", "accession": "KJ138219.1", "fmin": "118", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Stenotrophomonas maltophilia", "NCBI_taxonomy_id": "40324", "NCBI_taxonomy_cvterm_id": "37076"}, "protein_sequence": {"accession": "AHN60085.1", "sequence": "MAIRIFAILFSIFSLATFAHAQEGTLARSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR"}}}}}}}, "2786": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"4100": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "837": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "2268": {"$update": {"ARO_category": {"$delete": ["35919", "41687", "35945", "36189", "36218", "36526", "35936"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}}}}}, "1253": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1481": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "2386": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "2263": {"$update": {"ARO_category": {"$delete": ["37014", "35919", "41687", "36189", "35945", "35936"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}, "40599": {"category_aro_name": "tedizolid", "category_aro_cvterm_id": "40599", "category_aro_accession": "3003897", "category_aro_class_name": "Antibiotic", "category_aro_description": "Tedizolid is a synthetic oxazolidinone antibiotic that is administered to the patient as a prodrug that is activated in vivo. It acts as an inhibitor of protein synthesis by binding the 50S subunit of the ribosome and preventing formation of the 70S initiation complex. It is active against Gram-positive pathogens."}, "35989": {"category_aro_name": "linezolid", "category_aro_cvterm_id": "35989", "category_aro_accession": "0000072", "category_aro_class_name": "Antibiotic", "category_aro_description": "Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes."}, "36600": {"category_aro_name": "florfenicol", "category_aro_cvterm_id": "36600", "category_aro_accession": "3000461", "category_aro_class_name": "Antibiotic", "category_aro_description": "Florfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis."}, "36524": {"category_aro_name": "chloramphenicol", "category_aro_cvterm_id": "36524", "category_aro_accession": "3000385", "category_aro_class_name": "Antibiotic", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation."}}}}}, "2260": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "1400": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1668": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1011": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2036": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1655": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"5900": {"$update": {"dna_sequence": {"$update": {"fmax": "762", "sequence": "TTTTTTGCGGCATTTTGCTTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCA"}}, "protein_sequence": {"$update": {"sequence": "FFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA"}}}}}}}}}}, "974": {"$update": {"ARO_category": {"$delete": ["37014", "35919", "41687", "35945", "36189", "36218", "36526"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}}}}}, "1231": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "36189", "36218", "36526", "35936"], "$insert": {"41695": {"category_aro_name": "msr-type ABC-F protein", "category_aro_cvterm_id": "41695", "category_aro_accession": "3004471", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms."}}}}}, "1287": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1665": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1334": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"2020": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "303": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "445": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1725": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1776": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1788": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "242": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1232": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "103": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1470": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "847": {"$update": {"model_sequences": {"$update": {"sequence": {"8429": {"dna_sequence": {"partial": "1", "sequence": "GTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGCTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACC", "fmax": "862", "accession": "JF274245.1", "fmin": "1", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella sp. SH223", "NCBI_taxonomy_id": "1074434", "NCBI_taxonomy_cvterm_id": "39657"}, "protein_sequence": {"accession": "AEM44651.1", "sequence": "VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRAEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT"}}}}}}}, "1434": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1848": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1743": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "4053": {"$update": {"model_sequences": {"$update": {"sequence": {"8396": {"dna_sequence": {"partial": "0", "sequence": "ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGAACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACCTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCTACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA", "fmax": "2766", "accession": "FM179467.1", "fmin": "1938", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas putida", "NCBI_taxonomy_id": "303", "NCBI_taxonomy_cvterm_id": "36803"}, "protein_sequence": {"accession": "CAQ77073.1", "sequence": "MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGYADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR"}}}}}}}, "1430": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1942": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "4050": {"$update": {"model_sequences": {"$update": {"sequence": {"8395": {"dna_sequence": {"partial": "0", "sequence": "ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGAACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACCTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACGGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA", "fmax": "2979", "accession": "LLTZ01000057.1", "fmin": "2151", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "OPD39435.1", "sequence": "MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYGIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR"}}}}}}}, "33": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "36189", "36218", "36526", "35936"], "$insert": {"41695": {"category_aro_name": "msr-type ABC-F protein", "category_aro_cvterm_id": "41695", "category_aro_accession": "3004471", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms."}}}}}, "_version": "3.2.1", "4059": {"$update": {"model_sequences": {"$update": {"sequence": {"8398": {"dna_sequence": {"partial": "0", "sequence": "ATGATCATGTCGAAAAAATTAAAATGTCTGACGCTGTTTACAGCCATCTTTTTTGCGATTCCCATGGCCGCTTGTCAAAGTTTTAGTCAACAAAAGCAACAGCTTTCGACACAGAAAAATGAACAGCAACAGATTTCAAGCTTATTTCAGAGTGCCCAAACCAGTGGTGTTTTGGTGATTTATGATGGCAAGAAAATTCAAAGCTATGGCAATGATATACATCGCGCAGATCAGCGCTATATTCCTGCCTCAACCTTTAAAATGCTAAACGCCTTGATTGGTATACAACATCATAAGACCACACCAGATGAAGTGTTTAAATGGGATGGCAAAAAGCGGGCATTCAGCAGTTGGGAAAAAGATTTAACCTTAGCTGAAGCGATGCAGGCATCGGCGGTACCTGTGTATCAAGAGTTGGCAAGACGTATTGGCTTGGAGTTAATGACCCGTGAAGTGAAGCGTGTGGGTTATGGCAATAAAAATATTGGGACACAAGTTGATAATTTCTGGTTAGTTGGCCCATTAAAAATCACCCCCGTAGAAGAAGTTCGCTTTGCCTATGCGTTGGCAAAACAGAAATTGCCATTTGACCAGCCAACACAGCAACAAGTCAAAGCGATGTTATTGGTGGATCAGATTCAGGGAACTAAAATCTATGCAAAAAGTGGTTGGGGCATGGATGTTAGCCCGCAAGTGGGATGGTGGACAGGCTGGATTGAACAGCCAAATGGTAAGATCACAGCCTTCTCACTGAATATGCAAATGAGCCAGCCTGAGCATGCAGATGCACGTAAAGCGATTGTGTATCAAGCCTTGCAACAGTTGGGATTGTTAGCCCATTAA", "fmax": "162247", "accession": "AYEQ01000166.1", "fmin": "161404", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter gyllenbergii", "NCBI_taxonomy_id": "134534", "NCBI_taxonomy_cvterm_id": "42559"}, "protein_sequence": {"accession": "WP_023271137.1", "sequence": "MIMSKKLKCLTLFTAIFFAIPMAACQSFSQQKQQLSTQKNEQQQISSLFQSAQTSGVLVIYDGKKIQSYGNDIHRADQRYIPASTFKMLNALIGIQHHKTTPDEVFKWDGKKRAFSSWEKDLTLAEAMQASAVPVYQELARRIGLELMTREVKRVGYGNKNIGTQVDNFWLVGPLKITPVEEVRFAYALAKQKLPFDQPTQQQVKAMLLVDQIQGTKIYAKSGWGMDVSPQVGWWTGWIEQPNGKITAFSLNMQMSQPEHADARKAIVYQALQQLGLLAH"}}}}}}}, "109": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "647": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1727": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1074": {"$update": {"model_sequences": {"$update": {"sequence": {"8409": {"dna_sequence": {"partial": "1", "sequence": "GTTATCTCCCTGTTAGCCACCCTGCCACTGGTGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACAAATCGCCGGGATCGGCGCGGCGCTGATC", "fmax": "823", "accession": "AY130286.1", "fmin": "1", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAN05030.1", "sequence": "VISLLATLPLVVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQQIAGIGAALI"}}}}}}}, "579": {"$update": {"ARO_category": {"$delete": ["37018", "37716", "37013", "37016", "37017", "41687", "35919", "36189", "36218", "36526", "35936"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "36252": {"category_aro_name": "vga-type ABC-F protein", "category_aro_cvterm_id": "36252", "category_aro_accession": "3000113", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection."}}}}}, "3751": {"$update": {"model_sequences": {"$update": {"sequence": {"8385": {"dna_sequence": {"partial": "0", "sequence": "ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "fmax": "2937", "accession": "AM743197.2", "fmin": "2076", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance", "NCBI_taxonomy_id": "2", "NCBI_taxonomy_cvterm_id": "35506"}, "protein_sequence": {"accession": "WP_000027060.1", "sequence": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}}, "model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "500"}}}}}}, "571": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "1228": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8164": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1877": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1421": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1874": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"802": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "594": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"645": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1422": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1910": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "2054": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "36189", "36218", "36526", "35936"], "$insert": {"35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}, "41695": {"category_aro_name": "msr-type ABC-F protein", "category_aro_cvterm_id": "41695", "category_aro_accession": "3004471", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms."}}}}}, "1639": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1395": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "4068": {"$update": {"model_sequences": {"$update": {"sequence": {"8390": {"dna_sequence": {"partial": "0", "sequence": "ATGAAAATTCTGATTTTGCTGCCTTTATTTAGTTGCTTGGGACTGACGGCGTGTAGTCTGCCCGTTTCATCCTCCCCCTCTCAGATCACTTCAACTCAATCGACTCAAGAAGCCATTGCCCAATTATTTGATCAGGCGCAAAGCGCTGGCGTTTTAGTGATTCAGCGTGGTCAGCAGATACAGGTCTATGGTAATGATTTAGGCCGTGCAGATACCGAATATGTTCCCGCCTCTACTTTTAAAATGCTCAATGCCCTGATTGGCCTGCAACATGGCAAAGCCACAACCAATGAAATTTTTAAATGGGATGGCAAGAAACGCAGCTTTACCACCTGGGAAAAAGACATGACTCTCGGCGAAGCCATGCAAGCTTCTGCTGTACCCGTGTATCAGGAACTGGCACGTCGCATTGGCCTTGAATTGATGCAACAGGAAGTGAGACGTATTCAATTCGGCAATCAGCAGATTGGTCAACAGGTCGATAACTTCTGGTTGGTAGGCCCTTTGAAAGTTACTCCAAAACAGGAAGTCCAATTTGTTTCTGCGTTGGCCCGAGAGCAACTGGCCTTTGATCCTCAAGTCCAGCAACAAGTCAAAGCCATGTTATTTTTACAGGAGCGGAAAGCTTATCGACTATATGTCAAATCCGGTTGGGGCATGGATGTGGAACCGCAAGTCGGCTGGCTCACCGGCTGGGTTGAAACACCGCAGGCTGAAATCGTGACATTTTCACTCAATATGCAGATGCAAAATGGTATAGATCCGGCGATCCGCCTTGAAATTTTGCAGCAGGCTTTGGCCGAATTAGGGCTTTATCCAAAAGCTGAAGGATGA", "fmax": "8116", "accession": "LC537318.1", "fmin": "7282", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter lwoffii", "NCBI_taxonomy_id": "28090", "NCBI_taxonomy_cvterm_id": "36948"}, "protein_sequence": {"accession": "WP_168370988.1", "sequence": "MKILILLPLFSCLGLTACSLPVSSSPSQITSTQSTQEAIAQLFDQAQSAGVLVIQRGQQIQVYGNDLGRADTEYVPASTFKMLNALIGLQHGKATTNEIFKWDGKKRSFTTWEKDMTLGEAMQASAVPVYQELARRIGLELMQQEVRRIQFGNQQIGQQVDNFWLVGPLKVTPKQEVQFVSALAREQLAFDPQVQQQVKAMLFLQERKAYRLYVKSGWGMDVEPQVGWLTGWVETPQAEIVTFSLNMQMQNGIDPAIRLEILQQALAELGLYPKAEG"}}}}}}}, "1732": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1145": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1735": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "1503": {"$update": {"model_sequences": {"$update": {"sequence": {"8405": {"dna_sequence": {"partial": "1", "sequence": "GTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACAAATCGCCGGGATCGGCGCGGCGCTGATC", "fmax": "823", "accession": "AY130287.1", "fmin": "1", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAN05031.1", "sequence": "VISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQQIAGIGAALI"}}}}}}}, "3892": {"$update": {"model_sequences": {"$update": {"sequence": {"8387": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTGTGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "fmax": "1997", "accession": "KR061886.1", "fmin": "851", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "WP_032494240.1", "sequence": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDCAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ"}}}}}}}, "3890": {"$update": {"model_sequences": {"$update": {"sequence": {"8392": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGATTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "fmax": "1156", "accession": "KP860987.1", "fmin": "10", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "AKA60779.1", "sequence": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRFYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ"}}}}}}}, "631": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1077": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "468": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "755": {"$update": {"model_sequences": {"$update": {"sequence": {"8408": {"dna_sequence": {"partial": "1", "sequence": "CGTCTAGTTCTGCTGTCTTGTCTCTCATGGCCGCTGGCTGGCTTTTCTGCCACCGCGCTGACCAACCTCGTCGCGGAACCATTCGCTAAACTCGAACAGGACTTTGGCGGCTCCATCGGTGTGTACGCGATGGATACCGGCTCAGGCGCAACTGTAAGTTACCGCGCTGAGGAGCGCTTCCCACTGTGCAGCTCATTCAAGGGCTTTCTTGCTGCCGCTGTGCTGGCTCGCAGCCAGCAGCAGGCCGGCTTGCTGGACACACCCATCCGTTACGGCAAAAATGCGCTGGTTCCGTGGTCACCCATCTCGGAAAAATATCTGACAACAGGCATGACGGTGGCGGAGCTGTCCGCGGCCGCCGTGCAATACAGTGATAACGCCGCCGCCAATTTGTTGCTGAAGGAGTTGGGCGGCCCGGCCGGGCTGACGGCCTTCATGCGCTCTATCGGCGATACCACGTTCCGTCTGGACCGCTGGGAGCTGGAGCTGAACTCCGCCATCCCAGGCGATGCGCGCGATACCTCATCGCCGCGCGCCGTGACGGAAAGCTTACAAAAACTGACACTGGGCTCTGCACTGGCTGCGCCGCAGCGGCAGCAGTTTGTTGATTGGCTAAAGGGAAACACGACCGGCAACCACCGCATCCGCGCGGCGGTGCCGGCAGACTGGGCAGTCGGAGACAAAACCGGAACCTGCGGAGCGTATGGCACGGCAAATGACTATGCCGTCGTCTGGCCCACTGGGCGCGCACCTATTGTGTTGGCCGTCTACACCCGGGCGCCTAACAAGGATGACAAGTACAGCGAGGCCGTCATCGCCGCTGCGGCTAGACTCGCGCTCGAGGGATTGGGC", "fmax": "854", "accession": "FJ624872.1", "fmin": "2", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ACM91559.1", "sequence": "RLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGAYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLG"}}}}}}}, "638": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1341": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1612": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "460": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8209": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1594": {"$update": {"ARO_category": {"$insert": {"35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1599": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1560": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "11": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "15": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"931": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1626": {"$update": {"ARO_category": {"$delete": ["37018", "37716", "37013", "37016", "37017", "41687", "35919", "36189", "36218", "36526", "35936"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "36252": {"category_aro_name": "vga-type ABC-F protein", "category_aro_cvterm_id": "36252", "category_aro_accession": "3000113", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection."}}}}}, "1997": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "35945", "36189", "36218", "36526"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}}}}}, "1189": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "860": {"$update": {"model_sequences": {"$update": {"sequence": {"8426": {"dna_sequence": {"partial": "1", "sequence": "CAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATAAGTTGGGTGTACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCAGTAAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACATGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAG", "fmax": "843", "accession": "X98047.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "CAA66659.1", "sequence": "QHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGVRVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIK"}}}}}}}, "1628": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1389": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "4061": {"$update": {"model_sequences": {"$update": {"sequence": {"8389": {"dna_sequence": {"partial": "0", "sequence": "ATGATCATGTCGAAAAAATTAACATGTCTGGCCCTGTTTACAGCCATCTTTTTTGCGATTCCCATGGCCGCTTGTCAAAGTTTTAGTCAACAAAAGCAACAGCTTTCGACACAGAAAAATGAACAGCAACAGATTTCAAGCTTATTTCAGAGTGCCCAAACCAGTGGTGTTTTGGTGATTTATGATGGCAAGAAAATTCAAAGCTATGGCAATGATCTTGATCGTGCAGAACAGCGCTATATTCCTGCCTCAACCTTTAAAATGTTAAACGCCTTGATCGGCATACAGCATCATAAGACCACACCAGATGAAGTGTTTAAATGGGATGGTAAAAAGCGGGCATTCAGCAGTTGGGAAAAAGATTTAACCTTGGCTGAAGCCATGCAGGCATCGGCGGTACCTGTCTATCAGGAATTGGCACGACGTATTGGCTTAGAACTGATGACCCGTGAAGTGAAGCGTGTAGGTTATGGCAATAAAAATATCGGGACGCAAGTTGATACTTTCTGGTTGGTTGGCCCATTAAAAATCACCCCCGTAGAAGAAGTTCGCTTTGCCTATGCATTGGCAAAACAGAAGCTGCCATTTGACCAGCCAACGCAGCAACAAGTCAAAGCGATGTTATTGGTGGATCAGATTCAGGGAACTAAAATCTATGCCAAAAGTGGTTGGGGCATGGATGTTAGCCCTCAAGTGGGGTGGTTGACAGGCTGGATTGAACAGCCAAACGGTAAGATCACTGCCTTCTCGCTCAATATGCAAATGAGTCAGCCTGAACATGCAGATGCACGCAAAGTGATTGTGTATCAAGCCTTGCAACAGTTGGGATTGTTAGCCCATTAA", "fmax": "297289", "accession": "AQFL01000004.1", "fmin": "296446", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "unclassified Acinetobacter", "NCBI_taxonomy_id": "196816", "NCBI_taxonomy_cvterm_id": "45627"}, "protein_sequence": {"accession": "WP_016162389.1", "sequence": "MIMSKKLTCLALFTAIFFAIPMAACQSFSQQKQQLSTQKNEQQQISSLFQSAQTSGVLVIYDGKKIQSYGNDLDRAEQRYIPASTFKMLNALIGIQHHKTTPDEVFKWDGKKRAFSSWEKDLTLAEAMQASAVPVYQELARRIGLELMTREVKRVGYGNKNIGTQVDTFWLVGPLKITPVEEVRFAYALAKQKLPFDQPTQQQVKAMLLVDQIQGTKIYAKSGWGMDVSPQVGWLTGWIEQPNGKITAFSLNMQMSQPEHADARKVIVYQALQQLGLLAH"}}}}}}}, "709": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1246": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1748": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"41696": {"category_aro_name": "lsa-type ABC-F protein", "category_aro_cvterm_id": "41696", "category_aro_accession": "3004472", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome."}}}}}, "2021": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1065": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1517": {"$update": {"model_sequences": {"$update": {"sequence": {"8425": {"dna_sequence": {"partial": "1", "sequence": "GCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGTATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGAGAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTA", "fmax": "768", "accession": "AY008291.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AAG23871.1", "sequence": "ANIIYSSASASTDISTVASPLFEGTEGCFLLYDVSTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITIL"}}}}}}}, "728": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1158": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "2904": {"$update": {"ARO_category": {"$delete": ["35945", "41687", "37014", "35919", "35936"], "$insert": {"45630": {"category_aro_name": "Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins", "category_aro_cvterm_id": "45630", "category_aro_accession": "3007068", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification."}}}}}, "881": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1161": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"41696": {"category_aro_name": "lsa-type ABC-F protein", "category_aro_cvterm_id": "41696", "category_aro_accession": "3004472", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome."}}}}}, "159": {"$update": {"ARO_category": {"$delete": ["37018", "37716", "37013", "37016", "37017", "41687", "35919", "36189", "36218", "36526", "35936"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "36252": {"category_aro_name": "vga-type ABC-F protein", "category_aro_cvterm_id": "36252", "category_aro_accession": "3000113", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection."}}}}}, "1519": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "888": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1200": {"$update": {"ARO_category": {"$delete": ["37014", "41687", "36189", "36218", "36526", "35936"], "$insert": {"35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}, "41695": {"category_aro_name": "msr-type ABC-F protein", "category_aro_cvterm_id": "41695", "category_aro_accession": "3004471", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms."}}}}}, "1438": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1147": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1893": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"828": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1817": {"$update": {"ARO_category": {"$delete": ["37716", "35919", "37017", "41687", "37016", "36189", "36218", "36526", "35936"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "36252": {"category_aro_name": "vga-type ABC-F protein", "category_aro_cvterm_id": "36252", "category_aro_accession": "3000113", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection."}}}}}, "2130": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3687": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "950": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "872": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "1194": {"$update": {"model_sequences": {"$update": {"sequence": {"8404": {"dna_sequence": {"partial": "1", "sequence": "ATCGCGTGTCTTTCGAGTACGGCATTAGCTGGTTCAATTACAGAAAATACGTCTTGGAACAAAGAGTTCTCTGCCGAAGCCGTCAATGGTGTCTTCGTGCTTTGTAAAAGTAGCAGTAAATCCTGCGCTACCAATGACTTAGCTCGTGCATCAAAGGAATATCTTCCAGCATCAACATTTAAGATCCCCAACGCAATTATCGGCCTAGAAACTGGTGTCATAAAGAATGAGCATCAGGTTTTCAAATGGGACGGAAAGCCAAGAGCCATGAAGCAATGGGAAAGAGACTTGACCTTAAGAGGGGCAATACAAGTTTCAGCTGTTCCCGTATTTCAACAAATCACCAGAGAAGTTGGCGAAGTAAGAATGCAGAAATACCTTAAAAAATTTTCCTATGGCAACCAGAATATCAGTGGTGGCATTGACAAATTCTGGTTGGAAGACCAGCTTAGAATTTCCGCAGTTAATCAAGTGGAGTTTCTAGAGTCTCTATATTTAAATAAATTGTCAGCATCTAAAGAAAACCAGCTAATAGTAAAAGAGGCTTTGGTAACGGAGGCGGCACCTGAATATCTAGTGCATTCAAAAACTGGTTTTTCTGGTGTGGGAACTGAGTCAAATCCTGGTGTCGCATGGTGGGTTGGGTGGGTTGAGAAGGAGACAGAGGTTTACTTTTTCGCCTTTAACATGGATATAGACAACGAAAGTAAGTTGCCGCTAAGAAAATCCATTCCCACCAAAATCATGGAAAGTGAGGGCATCATTGGTGGCTAA", "fmax": "775", "accession": "AF043100.1", "fmin": "1", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287", "NCBI_taxonomy_cvterm_id": "36752"}, "protein_sequence": {"accession": "AAB97924.1", "sequence": "IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQITREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG"}}}}}}}, "2036": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"916": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1298": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}, "41696": {"category_aro_name": "lsa-type ABC-F protein", "category_aro_cvterm_id": "41696", "category_aro_accession": "3004472", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome."}, "35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}, "3975": {"$update": {"model_sequences": {"$update": {"sequence": {"8394": {"dna_sequence": {"partial": "0", "sequence": "GTGGTTAAGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCGGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "fmax": "867", "accession": "MF804906.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "WP_122630839.1", "sequence": "MVKRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQRERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}}}}}}}, "1117": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "1292": {"$update": {"model_sequences": {"$update": {"sequence": {"8420": {"dna_sequence": {"partial": "1", "sequence": "GTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCGAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCAAA", "fmax": "864", "accession": "JF274248.1", "fmin": "0", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Shigella sp. SH361", "NCBI_taxonomy_id": "1074437", "NCBI_taxonomy_cvterm_id": "39658"}, "protein_sequence": {"accession": "AEM44654.1", "sequence": "VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSRILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTK"}}}}}}}, "1293": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"883": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1753": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"829": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1751": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "890": {"$update": {"model_sequences": {"$update": {"sequence": {"8428": {"dna_sequence": {"partial": "1", "sequence": "ATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGATCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAAC", "fmax": "727", "accession": "AY590467.1", "fmin": "1", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573", "NCBI_taxonomy_cvterm_id": "35915"}, "protein_sequence": {"accession": "AAT01223.1", "sequence": "IISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLISQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNN"}}}}}}}, "3628": {"$update": {"model_sequences": {"$update": {"sequence": {"8380": {"dna_sequence": {"partial": "0", "sequence": "ATGTTGATTAAAAGCGAATATAAGCCCCGGATGCTGCCCAAAGAAGAGCAGGTCAAAAAGCCGATGACCAGTAACGGACGGATTAGCTTCGTCCTGATGGCAATGGCGGTCTTGTTTGCCTGTCTGATTGCCCGCGGGCTGTATCTGCAGACGGTAACGTATAACTTTTTGAAAGAACAGGGCGACAACCGGATTGTGCGGACTCAAGCATTGCCGGCTACACGCGGTACGGTTTCGGACCGGAACGGTGCGGTTTTGGCGTTGAGCGCGCCGACGGAGTCCCTGTTTGCCGTGCCTAAAGATATGAAGGAAATGCCGTCTGCCGCCCAATTGGAACGCCTGTCCGAGCTTGTCGATGTGCCGGTCGATGTTTTGAGGAACAAACTCGAACAGAAAGGCAAGTCGTTTATTTGGATCAAGCGGCAGCTCGATCCCAAGGTTGCCGAAGAGGTCAAAGCCTTGGGTTTGGAAAACTTTGTATTTGAAAAAGAATTAAAACGCCATTACCCGATGGGCAACCTGTTTGCACACGTCATCGGATTTACCGATATTGACGGCAAAGGTCAGGAAGGTTTGGAACTTTCGCTTGAAGACAGCCTGTATGGCGAAGACGGCGCGGAAGTTGTTTTGCGGGACCGGCAGGGCAATATTGTGGACAGCTTGGACTCCCCGCGCAATAAAGCACCGCAAAACGGCAAAGACATCATCCTTTCCCTCGATCAGAGGATTCAGACCTTGGCCTATGAAGAGTTGAACAAGGCGGTCGAATACCATCAGGCAAAAGCCGGAACGGTGGTGGTTTTGGATGCCCGCACGGGGGAAATCCTCGCCTTGGCCAATACGCCCGCCTACGATCCCAACAGACCCGGCCGGGCAGACAGCGAACAGCGGCGCAACCGTGCCGTAACCGATATGATCGAACCTGGTTCGGCAATCAAACCGTTCGTGATTGCGAAGGCATTGGATGCGGGCAAAACCGATTTGAACGAACGGCTGAATACGCAGCCTTATAAAATCGGACCGTCTCCCGTGCGCGATACCCATGTTTACCCCTCTTTGGATGTGCGCGGCATTATGCAGAAATCGTCCAACGTCGGCACAAGCAAACTGTCTGCGCGTTTCGGCGCCGAAGAAATGTATGACTTCTATCATGAATTGGGCATCGGTGTGCGTATGCACTCGGGCTTTCCGGGGGAAACTGCAGGTTTGTTGAGAAATTGGCGCAGGTGGCGGCCCATCGAACAGGCGACGATGTCTTTCGGTTACGGTCTGCAATTGAGCCTGCTGCAATTGGCGCGCGCCTATACCGCACTGACGCACGACGGCGTTTTGCTGCCGCTCAGCTTTGAGAAGCAGGCGGTTGCGCCGCAAGGCAAACGCATATTCAAAGAATCGACCGCGCGCGAGGTACGCAATCTGATGGTTTCCGTAACCGAGCCGGGCGGCACCGGTACGGCGGGTGCGGTGGACGGTTTCGATGTCGGCGCTAAAACCGGCACGGCGCGCAAGTTCGTCAACGGGCGTTATGCCGACAACAAACACGTCGCTACCTTTATCGGTTTTGCCCCCGCCAAAAACCCCCGTGTGATTGTGGCGGTAACCATCGACGAACCGACTGCCCACGGCTATTACGGCGGCGTAGTGGCAGGGCCGCCCTTCAAAAAAATTATGGGCGGCAGCCTGAACATCTTGGGCATTTCCCCGACCAAGCCACTGACCGCCGCAGCCGTCAAAACACCGTCTTAA", "fmax": "1848", "accession": "M32091.1", "fmin": "102", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Neisseria gonorrhoeae", "NCBI_taxonomy_id": "485", "NCBI_taxonomy_cvterm_id": "36806"}, "protein_sequence": {"accession": "AAA25463.1", "sequence": "MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAMAVLFACLIARGLYLQTVTYNFLKEQGDNRIVRTQALPATRGTVSDRNGAVLALSAPTESLFAVPKDMKEMPSAAQLERLSELVDVPVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLYGEDGAEVVLRDRQGNIVDSLDSPRNKAPQNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSLDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLARAYTALTHDGVLLPLSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHVATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS"}}}}}}}, "1172": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1925": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "772": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"960": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1270": {"$update": {"model_sequences": {"$update": {"sequence": {"8406": {"dna_sequence": {"partial": "1", "sequence": "GAAACCTACAATCATACATATCGGCACCGCAACTTTTCACATAAAGACTTAAGTGATCTCACCTTCACCGCTTGCACATTCATTCGCAGCGACTTTCGACGTGCTAACTTGCGTGATACGACATTCGTCAACTGCAAGTTCATTGAACAGGGTGATATCGAAGGCTGCCACTTTGATGTCGCAGATCTTCGTGATGCAAGTTTCCAACAATGCCAACTTGCGATGGCAAACTTCAGTAATGCCAATTGCTACGGTATAGAGTTCCGTGCGTGTGATTTAAAAGGTGCCAACTTTTCCCGAACAAACTTTGCCCATCAAGTGAGTAATCGTATGTACTTTTGCTCAGCATTTATTTCTGGATGTAATCTTTCCTATGCCAATATGGAGAGGGTTTGTTTAGAAAAATGTGAGTTGTTTGAAAATCGCTGGATAGGAACGAACCTAGCGGGTGCATCACTGAAAGAGTCAGACTTAAGTCGAGGTGTTTTTTCCGAAGATGTCTGGGGGCAATTTAGCCTACAGGGTGCCAATTTATGCCACGCCGAACTCGACGGTTTAGATCCCCGCAAAGTCGATACATCAGGTATCAAAATTGCAGCCTGGCAGCAAGAACTGATTCTCGAAGCACTGGGTATTGTTGTTTATCCTGACTAA", "fmax": "656", "accession": "EU077611.1", "fmin": "2", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "ABU52984.1", "sequence": "ETYNHTYRHRNFSHKDLSDLTFTACTFIRSDFRRANLRDTTFVNCKFIEQGDIEGCHFDVADLRDASFQQCQLAMANFSNANCYGIEFRACDLKGANFSRTNFAHQVSNRMYFCSAFISGCNLSYANMERVCLEKCELFENRWIGTNLAGASLKESDLSRGVFSEDVWGQFSLQGANLCHAELDGLDPRKVDTSGIKIAAWQQELILEALGIVVYPD"}}}}}}}, "610": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1312": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1686": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1931": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1275": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "35967": {"category_aro_name": "streptogramin B antibiotic", "category_aro_cvterm_id": "35967", "category_aro_accession": "0000050", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides.  Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics."}}}}}, "5737": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "45589": {"category_aro_name": "sal-type ABC-F protein", "category_aro_cvterm_id": "45589", "category_aro_accession": "3007030", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection."}}}}}, "486": {"$update": {"model_sequences": {"$update": {"sequence": {"8399": {"dna_sequence": {"partial": "0", "sequence": "GTGCGCTCAAAGAACTGTAATTGGCGGTATTCCCTTGCCGTCACTGTGTTGTTGTTATCACCTTTCGATTTACTGGCATCACTCGGCATGGACATGTACTTGCCAGCGGTGCCTTTCATGCCACATGCTCTTGGTACGACAGCGGGCACAATTCAGCTTACGCTGACAACGTATTTGGTCATGATAGGGGCCGGTCAGCTTTTGTTTGGGCCACTGTCGGACCGGCTGGGACGTCGTCCCGTGCTACTGGCGGGCGGTGCCGCCTACGTTGCGGCCTCAATCGGCCTCGTCGTCACGTCATCGGCTGGAGTATTTCTGGGTTTTCGGATTCTCCAAGCTTGTGGTGCCTCGGCATGCCTTGTTGCCACATTTGCAACAGTGCGTGATATCTACGCAGGTCGCAAGGAAAGTAACGTCATCTACGGCTTGCTTGGCTCTATGCTTGCTATGGTTCCGGCGATAGGCCCATTGCTGGGAGCGGTCATAGACACCTGGTTCGGGTGGCGGGCGATCTTTGCGTTCTTGGGATTGGGAATGATCGCTGCATTGACAGCAGCGTGGCGGCTCTGGCCTGAGACCCGGGTGCAGCGACCAGCAGCTTTGCAATGGTCACAACTTCTGCTTCCCATCAAGCACCTTAACTTCTGGTTGTACACAGTGTGTTATGCCGCAGGAATGGGCAGCTTCTTCGTCTTCTTCTCCATAGCGCCCGGATTGATGATGGGTAGGCAAGGCATGTCCCAGTTTGGCTTCAGTCTGTTGTTCGCAACAGTGGCAATTGCGATGATGCTTGCGGCCCGCTTCATGGGGCGCGTAATCGCCAAGTGGGGCAGCCTGAGTGCCTTGCGAATGGGGATGGGCTGCCTGATAGCAGGCGCAGTCTTGCTTGTCATCACCGAGCTATGGATTCCGCAGTCCGTGTTGGGCTTTATTGCCCCAATGTGGCTAGTGGGCGTCGGCGTCGCGACAGCGGTATCCGTTGCACCCAATGGTGCGCTTCGAGGGTTCGACCATATTGCAGGAGCCGTTACGGCAGTCTACTTCTGCTTGGGGGGGCTGCTGCTGGGGAGTGTTGGAACGCTCATCATTTCGCTGTTGCCGCGCGACACGGCCTGGCCAGTTATCGCGTATTGTTTGGTTCTTGCAACAATCGTGCTTGGACTGTCGTGTGTTTCCCGAGCGAGAGACCTTCGCGGTCACGGGGAGTATGATGCGGTTGCACGCACATAG", "fmax": "3871", "accession": "AF034958.3", "fmin": "2641", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Klebsiella aerogenes", "NCBI_taxonomy_id": "548", "NCBI_taxonomy_cvterm_id": "36770"}, "protein_sequence": {"accession": "AAD22144.1", "sequence": "MRSKNCNWRYSLAVTVLLLSPFDLLASLGMDMYLPAVPFMPHALGTTAGTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLAGGAAYVAASIGLVVTSSAGVFLGFRILQACGASACLVATFATVRDIYAGRKESNVIYGLLGSMLAMVPAIGPLLGAVIDTWFGWRAIFAFLGLGMIAALTAAWRLWPETRVQRPAALQWSQLLLPIKHLNFWLYTVCYAAGMGSFFVFFSIAPGLMMGRQGMSQFGFSLLFATVAIAMMLAARFMGRVIAKWGSLSALRMGMGCLIAGAVLLVITELWIPQSVLGFIAPMWLVGVGVATAVSVAPNGALRGFDHIAGAVTAVYFCLGGLLLGSVGTLIISLLPRDTAWPVIAYCLVLATIVLGLSCVSRARDLRGHGEYDAVART"}}}}}}}, "5739": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "45589": {"category_aro_name": "sal-type ABC-F protein", "category_aro_cvterm_id": "45589", "category_aro_accession": "3007030", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection."}}}}}, "5738": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "45589": {"category_aro_name": "sal-type ABC-F protein", "category_aro_cvterm_id": "45589", "category_aro_accession": "3007030", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection."}}}}}, "2123": {"$update": {"ARO_category": {"$delete": ["37018", "37716", "37013", "37016", "37017", "41687", "35919", "36189", "36218", "36526", "35936"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "36252": {"category_aro_name": "vga-type ABC-F protein", "category_aro_cvterm_id": "36252", "category_aro_accession": "3000113", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection."}}}}}, "_timestamp": "2022-04-25T16:09:23+00:00", "1046": {"$update": {"ARO_category": {"$delete": ["37018", "37716", "37013", "37016", "37017", "41687", "35919", "36189", "36218", "36526", "35936"], "$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}, "36252": {"category_aro_name": "vga-type ABC-F protein", "category_aro_cvterm_id": "36252", "category_aro_accession": "3000113", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection."}}}}}, "942": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1122": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1578": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1773": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1476": {"$update": {"model_sequences": {"$update": {"sequence": {"8407": {"dna_sequence": {"partial": "1", "sequence": "CAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATAAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTAAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATTGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCAGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "fmax": "853", "accession": "JX050178.1", "fmin": "1", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Proteus mirabilis", "NCBI_taxonomy_id": "584", "NCBI_taxonomy_cvterm_id": "36771"}, "protein_sequence": {"accession": "AFN69127.1", "sequence": "QHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNIGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW"}}}}}}}, "351": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1875": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "877": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1851": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "264": {"$update": {"ARO_category": {"$delete": ["36189", "36218", "41687", "36526", "35919"], "$insert": {"41696": {"category_aro_name": "lsa-type ABC-F protein", "category_aro_cvterm_id": "41696", "category_aro_accession": "3004472", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome."}}}}}, "806": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1064": {"$update": {"dna_sequence": {"$update": {"partial": "1"}}}}}}}}}}, "1642": {"$update": {"ARO_category": {"$insert": {"35952": {"category_aro_name": "streptogramin A antibiotic", "category_aro_cvterm_id": "35952", "category_aro_accession": "0000034", "category_aro_class_name": "Drug Class", "category_aro_description": "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics."}}}}}}}