Model_id Action ARO_name ARO_category Changes To Summary 1144 UPDATE vgbB virginiamycin S2; pristinamycin IB; quinupristin; pristinamycin IC; patricin B; patricin A; ostreogrycin B3; vernamycin C; streptogramin B antibiotic; pristinamycin IA; antibiotic inactivation; streptogramin antibiotic; streptogramin vgb lyase; ARO_category "UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1262 UPDATE SHV-149 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 127 UPDATE clbB dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; streptogramin A antibiotic; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 579 UPDATE vgaA streptogramin antibiotic; pleuromutilin antibiotic; streptogramin A antibiotic; antibiotic target protection; vga-type ABC-F protein; ARO_category "DELETED 37018 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with vga-type ABC-F protein UPDATED category_aro_cvterm_id with 36252 UPDATED category_aro_accession with 3000113 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. " 5740 UPDATE salE retapamulin; sal-type ABC-F protein; pleuromutilin antibiotic; tiamulin; streptogramin A antibiotic; antibiotic target protection; streptogramin antibiotic; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with sal-type ABC-F protein UPDATED category_aro_cvterm_id with 45589 UPDATED category_aro_accession with 3007030 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. " 5743 UPDATE msr(G) streptogramin antibiotic; macrolide antibiotic; msr-type ABC-F protein; antibiotic target protection; ARO_category "DELETED 37014 UPDATED category_aro_name with msr-type ABC-F protein UPDATED category_aro_cvterm_id with 41695 UPDATED category_aro_accession with 3004471 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. " 5744 UPDATE msr(I) streptogramin antibiotic; macrolide antibiotic; msr-type ABC-F protein; antibiotic target protection; ARO_category "DELETED 37014 UPDATED category_aro_name with msr-type ABC-F protein UPDATED category_aro_cvterm_id with 41695 UPDATED category_aro_accession with 3004471 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. " 1774 UPDATE CTX-M-106 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 " 2526 UPDATE vgbC virginiamycin S2; pristinamycin IB; quinupristin; pristinamycin IC; patricin B; patricin A; ostreogrycin B3; vernamycin C; streptogramin B antibiotic; pristinamycin IA; antibiotic inactivation; streptogramin antibiotic; streptogramin vgb lyase; ARO_category "UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 696 UPDATE cfrA dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; streptogramin A antibiotic; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 2523 UPDATE VatI dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin A antibiotic; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 698 UPDATE TEM-205 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 1075 UPDATE TEM-20 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 1549 UPDATE ErmB streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 280 UPDATE CTX-M-11 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 " 2013 UPDATE Erm(41) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; model_sequences; ARO_category "UPDATED partial with 0 UPDATED sequence with GTGGATCTGGGCGCAGGACACGGCGCGCTGACGGCACATCTGGTTGCCGCTGGCGCCAGGGTGCTAGCCGTCGAGCTGCATCCGGGGCGGGCTCGACACCTTCGTTCACGGTTTGCCGAGGAAGATGTCCGGGTAGCGGAAGCGGACCTACTCGCCTTCCGGTGGCCGCGACGGCCATTTCGGGTGGTGGCGAGCCCGCCCTACCAAGTCACCAGCGCACTGATCCGGAGTCTCTTGACGCCGGAATCCCGGCTGCTGGCTGCCGACCTGGTGCTGCAGCGCGGGGCTGTGCACAAACATGCGAAGCGAGCACCTGTTCGCCATTGGACGCTACGGGCCGGAATCACATTGCCGCGAAGCGCTTTCCATCATCCACCGCAGGTGGATTCGTCGGTGCTGGTGATCAGGCGGCGCTGA UPDATED fmax with 3469 UPDATED accession with EU177504.3 UPDATED fmin with 3052 UPDATED strand with + UPDATED NCBI_taxonomy_name with Mycobacteroides abscessus UPDATED NCBI_taxonomy_id with 36809 UPDATED NCBI_taxonomy_cvterm_id with 36888 UPDATED accession with ABW06859.1 UPDATED sequence with MDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSRFAEEDVRVAEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHPPQVDSSVLVIRRR UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 286 UPDATE SHV-162 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 3760 UPDATE CMY-150 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACATTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGGCAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCTCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA UPDATED fmax with 21380 UPDATED accession with QCWX01000028.1 UPDATED fmin with 20234 UPDATED strand with - UPDATED NCBI_taxonomy_name with Citrobacter freundii UPDATED NCBI_taxonomy_id with 546 UPDATED NCBI_taxonomy_cvterm_id with 36915 UPDATED accession with PUU64961.1 UPDATED sequence with MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKHSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASLVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ " 1097 UPDATE Erm(38) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1090 UPDATE TEM-169 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 1158 UPDATE SHV-22 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1156 UPDATE Erm(31) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 3484 UPDATE tva(A) Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; pleuromutilin antibiotic; antibiotic target protection; pleuromutilin; ARO_category "DELETED 35919 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. " 1319 UPDATE SHV-147 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 3400 UPDATE vga(E) Staphylococcus cohnii streptogramin antibiotic; pleuromutilin antibiotic; streptogramin A antibiotic; antibiotic target protection; vga-type ABC-F protein; ARO_category "DELETED 37018 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with vga-type ABC-F protein UPDATED category_aro_cvterm_id with 36252 UPDATED category_aro_accession with 3000113 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. " 5751 UPDATE OXA-290 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATTGGACTGACGTTGCTAGGTTGCCAAAATTTGCACGCCCCAACTCAAAGCGCCGTGTCAAAAAAACACGATCAAACCGAGATCGCTTCTTTATTCCAACATACTCAAACTGTTGGCGTATTTGTTACATATGATGGGCAAACATTTCAAGAATATGGCAATGCGTTGAGTCGATCGAATACGGCTTATATTCCAGCCTCAACCTTCAAGATGTTAAATGCTCTGATTGGGATACAGCATCACAAAAGTTCGCCCAACGAAGTGTTTAAATGGGATGGCAAAAAGCGTGCTTTTGCGAGCTGGGAAAAAGATTTAACTTTAGCCGAGGCGATGCAGGCATCAGCAGTGCCTGTTTATCAGGAATTGGCTCGGCGTATCGGGTTAGAGTTGATGGCGAACGAAGTAAAACGCGTTGGCTTTGGCAATACTGAGATCGGAACGCAAGTCGATGATTTTTGGTTGGTTGGCCCGCTTAAGATTACCCCCGTTGACGAAGTGAAATTTGCTTATGCTCTGGCAAATAAGCAGCTTGCATTTGACCAATCTGTGCAAGAACAAGTGAAACAGATGGTCTTCGTTGATGAAGTTCATGGAACTAAGATTTATGCCAAAAGTGGTTGGGGTATGGATGTAACACCGCAAGTGGGTTGGTGGACGGGCTGGATTGAACAACCGAATGGACAGGTGATTGCATTTGCTTTAAATCTGGAAATAAATAAGCCTGAGCACGGTGATGCGCGTAAAGCGATTGTTTATCAAGCATTACAACAATTGAAATTGTTACAGAAGCAATAA UPDATED fmax with 290736 UPDATED accession with APOK01000044.1 UPDATED fmin with 289938 UPDATED strand with - UPDATED NCBI_taxonomy_name with Acinetobacter sp. CIP-A165 UPDATED NCBI_taxonomy_id with 40373 UPDATED NCBI_taxonomy_cvterm_id with 39511 UPDATED accession with ENU29139.1 UPDATED sequence with MIGLTLLGCQNLHAPTQSAVSKKHDQTEIASLFQHTQTVGVFVTYDGQTFQEYGNALSRSNTAYIPASTFKMLNALIGIQHHKSSPNEVFKWDGKKRAFASWEKDLTLAEAMQASAVPVYQELARRIGLELMANEVKRVGFGNTEIGTQVDDFWLVGPLKITPVDEVKFAYALANKQLAFDQSVQEQVKQMVFVDEVHGTKIYAKSGWGMDVTPQVGWWTGWIEQPNGQVIAFALNLEINKPEHGDARKAIVYQALQQLKLLQKQ " 260 UPDATE ErmN streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1953 UPDATE SHV-155 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 3406 UPDATE OXA-140 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with TTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGCATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGATAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATAT UPDATED fmax with 706 UPDATED accession with KR780479.1 UPDATED fmin with 1 UPDATED strand with - UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae subsp. pneumoniae UPDATED NCBI_taxonomy_id with 72407 UPDATED NCBI_taxonomy_cvterm_id with 39097 UPDATED accession with ALL27283.1 UPDATED sequence with FAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKY " 128 UPDATE srmB Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; spiramycin; antibiotic target protection; macrolide antibiotic; ARO_category "DELETED 37014 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. " 1701 UPDATE Erm(39) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1400 UPDATE CTX-M-74 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 " 1829 UPDATE CMY-87 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 1 " 56 UPDATE TEM-7 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with TTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATAAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATAGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGA UPDATED fmax with 783 UPDATED accession with AF527798.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AAO33760.1 UPDATED sequence with FFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNR " 1066 UPDATE TEM-118 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with TTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCATTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACATGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGA UPDATED fmax with 783 UPDATED accession with AY130285.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella oxytoca UPDATED NCBI_taxonomy_id with 571 UPDATED NCBI_taxonomy_cvterm_id with 36788 UPDATED accession with AAN05029.1 UPDATED sequence with FFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNR " 928 UPDATE carA carbomycin; Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; antibiotic target protection; macrolide antibiotic; ARO_category "DELETED 37014 UPDATED category_aro_name with carbomycin UPDATED category_aro_cvterm_id with 37627 UPDATED category_aro_accession with 3001228 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Produced by Streptomyces halstedii and Streptomyces thermotolerans. UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. " 1388 UPDATE oleB Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; macrolide antibiotic; oleandomycin; antibiotic target protection; ARO_category "DELETED 37014 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. " 3847 UPDATE lsa(D) streptogramin antibiotic; pleuromutilin antibiotic; lsa-type ABC-F protein; antibiotic target protection; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with lsa-type ABC-F protein UPDATED category_aro_cvterm_id with 41696 UPDATED category_aro_accession with 3004472 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome. " 825 UPDATE SHV-20 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1412 UPDATE SHV-167 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 2265 UPDATE salA retapamulin; sal-type ABC-F protein; virginiamycin M1; pleuromutilin antibiotic; tiamulin; streptogramin A antibiotic; lincomycin; antibiotic target protection; streptogramin antibiotic; clindamycin; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with sal-type ABC-F protein UPDATED category_aro_cvterm_id with 45589 UPDATED category_aro_accession with 3007030 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. " 374 UPDATE SHV-21 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 290 UPDATE vatD dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin A antibiotic; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 877 UPDATE SHV-124 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 989 UPDATE ErmG streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 2907 UPDATE vmlR virginiamycin S2; Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; streptogramin B antibiotic; lincomycin; antibiotic target protection; streptogramin antibiotic; lincosamide antibiotic; ARO_category "DELETED 37014 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 3822 UPDATE msrH streptogramin antibiotic; macrolide antibiotic; msr-type ABC-F protein; antibiotic target protection; ARO_category "DELETED 37014 UPDATED category_aro_name with msr-type ABC-F protein UPDATED category_aro_cvterm_id with 41695 UPDATED category_aro_accession with 3004471 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. " 3821 UPDATE msrF streptogramin antibiotic; macrolide antibiotic; msr-type ABC-F protein; antibiotic target protection; ARO_category "DELETED 37014 UPDATED category_aro_name with msr-type ABC-F protein UPDATED category_aro_cvterm_id with 41695 UPDATED category_aro_accession with 3004471 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. " 1080 UPDATE SHV-158 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 3944 UPDATE OXA-544 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGAACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACTTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA UPDATED fmax with 3203 UPDATED accession with LLMY01000078.1 UPDATED fmin with 2375 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with OPD39420.1 UPDATED sequence with MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKILHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR " 190 UPDATE OXA-195 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 " 985 UPDATE ErmA streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 271 UPDATE CMY-4 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 1 " 279 UPDATE CTX-M-107 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with GTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAGAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACC UPDATED fmax with 863 UPDATED accession with JF274244.1 UPDATED fmin with 2 UPDATED strand with - UPDATED NCBI_taxonomy_name with Shigella sp. SH219 UPDATED NCBI_taxonomy_id with 1074433 UPDATED NCBI_taxonomy_cvterm_id with 39656 UPDATED accession with AEM44650.1 UPDATED sequence with VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDRTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT " 2826 UPDATE Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics pristinamycin IA; josamycin; 23S rRNA with mutation conferring resistance to macrolide antibiotics; virginiamycin M1; macrolide antibiotic; streptogramin A antibiotic; antibiotic target alteration; streptogramin antibiotic; 23S rRNA with mutation conferring resistance to streptogramins antibiotics; tylosin; streptogramin B antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1488 UPDATE TEM-75 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with TTTTTTGCGGCATTTTGCTTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCATTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACATGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGA UPDATED fmax with 783 UPDATED accession with AY130284.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAN05028.1 UPDATED sequence with FFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNR " 3300 UPDATE clcD dalfopristin; quinupristin; quinupristin-dalfopristin; streptogramin B antibiotic; pleuromutilin antibiotic; tiamulin; linezolid; streptogramin A antibiotic; florfenicol; oxazolidinone antibiotic; antibiotic target alteration; streptogramin antibiotic; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; lincosamide antibiotic; ARO_category "UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 4046 UPDATE OXA-540 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGCACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACCTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA UPDATED fmax with 946 UPDATED accession with KJ138219.1 UPDATED fmin with 118 UPDATED strand with + UPDATED NCBI_taxonomy_name with Stenotrophomonas maltophilia UPDATED NCBI_taxonomy_id with 40324 UPDATED NCBI_taxonomy_cvterm_id with 37076 UPDATED accession with AHN60085.1 UPDATED sequence with MAIRIFAILFSIFSLATFAHAQEGTLARSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR " 2786 UPDATE Burkholderia pseudomallei Omp38 penam; reduced permeability to antibiotic; imipenem; penem; benzylpenicillin; cephalosporin; carbapenem; ceftazidime; cephamycin; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; cefoxitin; model_sequences "UPDATED partial with 1 " 837 UPDATE vatH dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin A antibiotic; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 2268 UPDATE eatAv Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; pleuromutilin antibiotic; antibiotic target protection; pleuromutilin; ARO_category "DELETED 35919 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. " 1253 UPDATE GES-23 carbapenem; penam; cephalosporin; antibiotic inactivation; GES beta-lactamase; model_sequences "UPDATED partial with 1 " 2386 UPDATE cipA dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; streptogramin A antibiotic; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 2263 UPDATE optrA tedizolid; antibiotic target protection; Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; linezolid; florfenicol; oxazolidinone antibiotic; phenicol antibiotic; chloramphenicol; ARO_category "DELETED 37014 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. UPDATED category_aro_name with tedizolid UPDATED category_aro_cvterm_id with 40599 UPDATED category_aro_accession with 3003897 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tedizolid is a synthetic oxazolidinone antibiotic that is administered to the patient as a prodrug that is activated in vivo. It acts as an inhibitor of protein synthesis by binding the 50S subunit of the ribosome and preventing formation of the 70S initiation complex. It is active against Gram-positive pathogens. UPDATED category_aro_name with chloramphenicol UPDATED category_aro_cvterm_id with 36524 UPDATED category_aro_accession with 3000385 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation. UPDATED category_aro_name with florfenicol UPDATED category_aro_cvterm_id with 36600 UPDATED category_aro_accession with 3000461 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Florfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. UPDATED category_aro_name with linezolid UPDATED category_aro_cvterm_id with 35989 UPDATED category_aro_accession with 0000072 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. " 2260 UPDATE vatF dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin A antibiotic; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 916 UPDATE OXA-36 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 " 1011 UPDATE TEM-29 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 1655 UPDATE TEM-117 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED fmax with 762 UPDATED sequence with TTTTTTGCGGCATTTTGCTTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCA UPDATED sequence with FFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA " 1231 UPDATE mel macrolide antibiotic; telithromycin; msr-type ABC-F protein; antibiotic target protection; streptogramin antibiotic; erythromycin; ARO_category "DELETED 37014 UPDATED category_aro_name with msr-type ABC-F protein UPDATED category_aro_cvterm_id with 41695 UPDATED category_aro_accession with 3004471 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. " 1334 UPDATE SHV-126 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 303 UPDATE ErmQ streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 445 UPDATE TEM-22 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 1776 UPDATE SHV-159 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 2123 UPDATE vgaC streptogramin antibiotic; pleuromutilin antibiotic; streptogramin A antibiotic; antibiotic target protection; vga-type ABC-F protein; ARO_category "DELETED 37018 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with vga-type ABC-F protein UPDATED category_aro_cvterm_id with 36252 UPDATED category_aro_accession with 3000113 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. " 242 UPDATE SHV-152 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 103 UPDATE SHV-12 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; cefalotin; ceftriaxone; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 872 UPDATE vatC dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin A antibiotic; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 847 UPDATE CTX-M-108 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with GTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGCTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACC UPDATED fmax with 862 UPDATED accession with JF274245.1 UPDATED fmin with 1 UPDATED strand with + UPDATED NCBI_taxonomy_name with Shigella sp. SH223 UPDATED NCBI_taxonomy_id with 1074434 UPDATED NCBI_taxonomy_cvterm_id with 39657 UPDATED accession with AEM44651.1 UPDATED sequence with VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRAEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT " 1434 UPDATE Erm(35) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1848 UPDATE CTX-M-75 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 " 4053 UPDATE OXA-541 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGAACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACCTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCTACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA UPDATED fmax with 2766 UPDATED accession with FM179467.1 UPDATED fmin with 1938 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas putida UPDATED NCBI_taxonomy_id with 303 UPDATED NCBI_taxonomy_cvterm_id with 36803 UPDATED accession with CAQ77073.1 UPDATED sequence with MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGYADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR " 1430 UPDATE SHV-125 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 4050 UPDATE OXA-543 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGAACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACCTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACGGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA UPDATED fmax with 2979 UPDATED accession with LLTZ01000057.1 UPDATED fmin with 2151 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with OPD39435.1 UPDATED sequence with MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYGIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR " 33 UPDATE msrE streptogramin antibiotic; antibiotic target protection; macrolide antibiotic; msr-type ABC-F protein; erythromycin; ARO_category "DELETED 37014 UPDATED category_aro_name with msr-type ABC-F protein UPDATED category_aro_cvterm_id with 41695 UPDATED category_aro_accession with 3004471 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. " 4059 UPDATE OXA-672 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATCATGTCGAAAAAATTAAAATGTCTGACGCTGTTTACAGCCATCTTTTTTGCGATTCCCATGGCCGCTTGTCAAAGTTTTAGTCAACAAAAGCAACAGCTTTCGACACAGAAAAATGAACAGCAACAGATTTCAAGCTTATTTCAGAGTGCCCAAACCAGTGGTGTTTTGGTGATTTATGATGGCAAGAAAATTCAAAGCTATGGCAATGATATACATCGCGCAGATCAGCGCTATATTCCTGCCTCAACCTTTAAAATGCTAAACGCCTTGATTGGTATACAACATCATAAGACCACACCAGATGAAGTGTTTAAATGGGATGGCAAAAAGCGGGCATTCAGCAGTTGGGAAAAAGATTTAACCTTAGCTGAAGCGATGCAGGCATCGGCGGTACCTGTGTATCAAGAGTTGGCAAGACGTATTGGCTTGGAGTTAATGACCCGTGAAGTGAAGCGTGTGGGTTATGGCAATAAAAATATTGGGACACAAGTTGATAATTTCTGGTTAGTTGGCCCATTAAAAATCACCCCCGTAGAAGAAGTTCGCTTTGCCTATGCGTTGGCAAAACAGAAATTGCCATTTGACCAGCCAACACAGCAACAAGTCAAAGCGATGTTATTGGTGGATCAGATTCAGGGAACTAAAATCTATGCAAAAAGTGGTTGGGGCATGGATGTTAGCCCGCAAGTGGGATGGTGGACAGGCTGGATTGAACAGCCAAATGGTAAGATCACAGCCTTCTCACTGAATATGCAAATGAGCCAGCCTGAGCATGCAGATGCACGTAAAGCGATTGTGTATCAAGCCTTGCAACAGTTGGGATTGTTAGCCCATTAA UPDATED fmax with 162247 UPDATED accession with AYEQ01000166.1 UPDATED fmin with 161404 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter gyllenbergii UPDATED NCBI_taxonomy_id with 134534 UPDATED NCBI_taxonomy_cvterm_id with 42559 UPDATED accession with WP_023271137.1 UPDATED sequence with MIMSKKLKCLTLFTAIFFAIPMAACQSFSQQKQQLSTQKNEQQQISSLFQSAQTSGVLVIYDGKKIQSYGNDIHRADQRYIPASTFKMLNALIGIQHHKTTPDEVFKWDGKKRAFSSWEKDLTLAEAMQASAVPVYQELARRIGLELMTREVKRVGYGNKNIGTQVDNFWLVGPLKITPVEEVRFAYALAKQKLPFDQPTQQQVKAMLLVDQIQGTKIYAKSGWGMDVSPQVGWWTGWIEQPNGKITAFSLNMQMSQPEHADARKAIVYQALQQLGLLAH " 109 UPDATE ErmE streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 647 UPDATE TEM-89 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 1074 UPDATE LEN-3 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences "UPDATED partial with 1 UPDATED sequence with GTTATCTCCCTGTTAGCCACCCTGCCACTGGTGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTGTCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACAAATCGCCGGGATCGGCGCGGCGCTGATC UPDATED fmax with 823 UPDATED accession with AY130286.1 UPDATED fmin with 1 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAN05030.1 UPDATED sequence with VISLLATLPLVVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQQIAGIGAALI " 621 UPDATE ErmF streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 3751 UPDATE TEM-181 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences; model_param "UPDATED partial with 0 UPDATED sequence with ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA UPDATED fmax with 2937 UPDATED accession with AM743197.2 UPDATED fmin with 2076 UPDATED strand with - UPDATED NCBI_taxonomy_name with Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance UPDATED NCBI_taxonomy_id with 2 UPDATED NCBI_taxonomy_cvterm_id with 35506 UPDATED accession with WP_000027060.1 UPDATED sequence with MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW UPDATED param_value with 500 " 1422 UPDATE ACC-3 penam; monobactam; cephalosporin; ACC beta-lactamase; antibiotic inactivation; model_sequences "UPDATED partial with 1 " 571 UPDATE clbA dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; streptogramin A antibiotic; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 1228 UPDATE CMY-30 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 1 " 1877 UPDATE CMY-12 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 1 " 1874 UPDATE OXA-196 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 " 594 UPDATE QnrB41 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; model_sequences "UPDATED partial with 1 " 974 UPDATE lmrC celesticetin; Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; lincomycin; antibiotic target protection; clindamycin; lincosamide antibiotic; ARO_category "DELETED 37014 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. " 2054 UPDATE msrC quinupristin; macrolide antibiotic; streptogramin B antibiotic; msr-type ABC-F protein; antibiotic target protection; streptogramin antibiotic; erythromycin; ARO_category "DELETED 37014 UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. UPDATED category_aro_name with msr-type ABC-F protein UPDATED category_aro_cvterm_id with 41695 UPDATED category_aro_accession with 3004471 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. " 1639 UPDATE SHV-84 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 4068 UPDATE OXA-915 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAAAATTCTGATTTTGCTGCCTTTATTTAGTTGCTTGGGACTGACGGCGTGTAGTCTGCCCGTTTCATCCTCCCCCTCTCAGATCACTTCAACTCAATCGACTCAAGAAGCCATTGCCCAATTATTTGATCAGGCGCAAAGCGCTGGCGTTTTAGTGATTCAGCGTGGTCAGCAGATACAGGTCTATGGTAATGATTTAGGCCGTGCAGATACCGAATATGTTCCCGCCTCTACTTTTAAAATGCTCAATGCCCTGATTGGCCTGCAACATGGCAAAGCCACAACCAATGAAATTTTTAAATGGGATGGCAAGAAACGCAGCTTTACCACCTGGGAAAAAGACATGACTCTCGGCGAAGCCATGCAAGCTTCTGCTGTACCCGTGTATCAGGAACTGGCACGTCGCATTGGCCTTGAATTGATGCAACAGGAAGTGAGACGTATTCAATTCGGCAATCAGCAGATTGGTCAACAGGTCGATAACTTCTGGTTGGTAGGCCCTTTGAAAGTTACTCCAAAACAGGAAGTCCAATTTGTTTCTGCGTTGGCCCGAGAGCAACTGGCCTTTGATCCTCAAGTCCAGCAACAAGTCAAAGCCATGTTATTTTTACAGGAGCGGAAAGCTTATCGACTATATGTCAAATCCGGTTGGGGCATGGATGTGGAACCGCAAGTCGGCTGGCTCACCGGCTGGGTTGAAACACCGCAGGCTGAAATCGTGACATTTTCACTCAATATGCAGATGCAAAATGGTATAGATCCGGCGATCCGCCTTGAAATTTTGCAGCAGGCTTTGGCCGAATTAGGGCTTTATCCAAAAGCTGAAGGATGA UPDATED fmax with 8116 UPDATED accession with LC537318.1 UPDATED fmin with 7282 UPDATED strand with + UPDATED NCBI_taxonomy_name with Acinetobacter lwoffii UPDATED NCBI_taxonomy_id with 28090 UPDATED NCBI_taxonomy_cvterm_id with 36948 UPDATED accession with WP_168370988.1 UPDATED sequence with MKILILLPLFSCLGLTACSLPVSSSPSQITSTQSTQEAIAQLFDQAQSAGVLVIQRGQQIQVYGNDLGRADTEYVPASTFKMLNALIGLQHGKATTNEIFKWDGKKRSFTTWEKDMTLGEAMQASAVPVYQELARRIGLELMQQEVRRIQFGNQQIGQQVDNFWLVGPLKVTPKQEVQFVSALAREQLAFDPQVQQQVKAMLFLQERKAYRLYVKSGWGMDVEPQVGWLTGWVETPQAEIVTFSLNMQMQNGIDPAIRLEILQQALAELGLYPKAEG " 1732 UPDATE SHV-151 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1735 UPDATE vatA dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin A antibiotic; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 1503 UPDATE LEN-4 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences "UPDATED partial with 1 UPDATED sequence with GTTATCTCCCTGTTAGCCACCCTGCCACTGGCGGTAGACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCCGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACAGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGGGAAACGGCACTGAATGAGGCGCTTCCCGGCGACGCGCGCGACACCACCACCCCGGCCAGCATGGCCGCCACGCTGCGCAAACTACTGACCGCGCAGCATCTGAGCGCCCGTTCGCAACAGCAACTCCTGCAGTGGATGGTGGACGATCGGGTTGCCGGCCCGCTGATCCGCGCCGTGCTGCCGCCGGGCTGGTTTATCGCCGACAAAACCGGGGCTGGCGAACGGGGTGCGCGCGGCATTGTCGCCCTGCTCGGCCCGGACGGCAAACCGGAGCGCATTGTGGTGATCTATCTGCGGGATACCCCGGCGAGTATGGCCGAGCGTAATCAACAAATCGCCGGGATCGGCGCGGCGCTGATC UPDATED fmax with 823 UPDATED accession with AY130287.1 UPDATED fmin with 1 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAN05031.1 UPDATED sequence with VISLLATLPLAVDAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQQIAGIGAALI " 3892 UPDATE CMY-107 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTGTGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA UPDATED fmax with 1997 UPDATED accession with KR061886.1 UPDATED fmin with 851 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with WP_032494240.1 UPDATED sequence with MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDCAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ " 3890 UPDATE CMY-134 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGATTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA UPDATED fmax with 1156 UPDATED accession with KP860987.1 UPDATED fmin with 10 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with AKA60779.1 UPDATED sequence with MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRFYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ " 631 UPDATE TEM-21 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 468 UPDATE Erm(37) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 755 UPDATE KPC-9 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with CGTCTAGTTCTGCTGTCTTGTCTCTCATGGCCGCTGGCTGGCTTTTCTGCCACCGCGCTGACCAACCTCGTCGCGGAACCATTCGCTAAACTCGAACAGGACTTTGGCGGCTCCATCGGTGTGTACGCGATGGATACCGGCTCAGGCGCAACTGTAAGTTACCGCGCTGAGGAGCGCTTCCCACTGTGCAGCTCATTCAAGGGCTTTCTTGCTGCCGCTGTGCTGGCTCGCAGCCAGCAGCAGGCCGGCTTGCTGGACACACCCATCCGTTACGGCAAAAATGCGCTGGTTCCGTGGTCACCCATCTCGGAAAAATATCTGACAACAGGCATGACGGTGGCGGAGCTGTCCGCGGCCGCCGTGCAATACAGTGATAACGCCGCCGCCAATTTGTTGCTGAAGGAGTTGGGCGGCCCGGCCGGGCTGACGGCCTTCATGCGCTCTATCGGCGATACCACGTTCCGTCTGGACCGCTGGGAGCTGGAGCTGAACTCCGCCATCCCAGGCGATGCGCGCGATACCTCATCGCCGCGCGCCGTGACGGAAAGCTTACAAAAACTGACACTGGGCTCTGCACTGGCTGCGCCGCAGCGGCAGCAGTTTGTTGATTGGCTAAAGGGAAACACGACCGGCAACCACCGCATCCGCGCGGCGGTGCCGGCAGACTGGGCAGTCGGAGACAAAACCGGAACCTGCGGAGCGTATGGCACGGCAAATGACTATGCCGTCGTCTGGCCCACTGGGCGCGCACCTATTGTGTTGGCCGTCTACACCCGGGCGCCTAACAAGGATGACAAGTACAGCGAGGCCGTCATCGCCGCTGCGGCTAGACTCGCGCTCGAGGGATTGGGC UPDATED fmax with 854 UPDATED accession with FJ624872.1 UPDATED fmin with 2 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ACM91559.1 UPDATED sequence with RLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGAYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLG " 638 UPDATE ACT-16 antibiotic inactivation; carbapenem; penam; ACT beta-lactamase; cephalosporin; cephamycin; model_sequences "UPDATED partial with 1 " 460 UPDATE CMY-29 antibiotic inactivation; CMY beta-lactamase; cephamycin; model_sequences "UPDATED partial with 1 " 1594 UPDATE vgbA virginiamycin S2; pristinamycin IB; quinupristin; pristinamycin IC; patricin B; patricin A; ostreogrycin B3; vernamycin C; streptogramin B antibiotic; pristinamycin IA; antibiotic inactivation; streptogramin antibiotic; streptogramin vgb lyase; ARO_category "UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1599 UPDATE SHV-23 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 11 UPDATE Erm(34) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 15 UPDATE TEM-59 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 1626 UPDATE vgaE streptogramin antibiotic; pleuromutilin antibiotic; streptogramin A antibiotic; antibiotic target protection; vga-type ABC-F protein; ARO_category "DELETED 37018 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with vga-type ABC-F protein UPDATED category_aro_cvterm_id with 36252 UPDATED category_aro_accession with 3000113 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. " 1997 UPDATE tlrC mycinamicin; Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; macrolide antibiotic; lincomycin; antibiotic target protection; tylosin; lincosamide antibiotic; ARO_category "DELETED 37014 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. " 1189 UPDATE vatB dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin A antibiotic; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 860 UPDATE TEM-42 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with CAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATAAGTTGGGTGTACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCAGTAAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACATGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAG UPDATED fmax with 843 UPDATED accession with X98047.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with CAA66659.1 UPDATED sequence with QHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGVRVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIK " 1628 UPDATE SHV-154 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 709 UPDATE TEM-213 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 1748 UPDATE lsaC pleuromutilin; pleuromutilin antibiotic; lsa-type ABC-F protein; lincomycin; antibiotic target protection; streptogramin antibiotic; clindamycin; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with lsa-type ABC-F protein UPDATED category_aro_cvterm_id with 41696 UPDATED category_aro_accession with 3004472 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome. " 2021 UPDATE SHV-165 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1517 UPDATE OXA-33 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with GCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGTATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGAGAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTA UPDATED fmax with 768 UPDATED accession with AY008291.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AAG23871.1 UPDATED sequence with ANIIYSSASASTDISTVASPLFEGTEGCFLLYDVSTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITIL " 728 UPDATE TEM-192 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 " 2904 UPDATE poxtA antibiotic target protection; Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; linezolid; tetracycline; florfenicol; tetracycline antibiotic; oxazolidinone antibiotic; phenicol antibiotic; doxycycline; chloramphenicol; ARO_category "DELETED 35945 UPDATED category_aro_name with Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins UPDATED category_aro_cvterm_id with 45630 UPDATED category_aro_accession with 3007068 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. " 881 UPDATE ErmC streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1161 UPDATE lsaB pleuromutilin; pleuromutilin antibiotic; lsa-type ABC-F protein; antibiotic target protection; streptogramin antibiotic; clindamycin; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with lsa-type ABC-F protein UPDATED category_aro_cvterm_id with 41696 UPDATED category_aro_accession with 3004472 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome. " 159 UPDATE vgaALC streptogramin antibiotic; pleuromutilin antibiotic; streptogramin A antibiotic; antibiotic target protection; vga-type ABC-F protein; ARO_category "DELETED 37018 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with vga-type ABC-F protein UPDATED category_aro_cvterm_id with 36252 UPDATED category_aro_accession with 3000113 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. " 1519 UPDATE vatE dalfopristin; antibiotic inactivation; streptogramin vat acetyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin A antibiotic; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 888 UPDATE Erm(36) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1200 UPDATE msrA quinupristin; macrolide antibiotic; streptogramin B antibiotic; msr-type ABC-F protein; antibiotic target protection; streptogramin antibiotic; erythromycin; ARO_category "DELETED 37014 UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. UPDATED category_aro_name with msr-type ABC-F protein UPDATED category_aro_cvterm_id with 41695 UPDATED category_aro_accession with 3004471 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. " 3628 UPDATE Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics penam; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; cephamycin; cefixime; ceftriaxone; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGTTGATTAAAAGCGAATATAAGCCCCGGATGCTGCCCAAAGAAGAGCAGGTCAAAAAGCCGATGACCAGTAACGGACGGATTAGCTTCGTCCTGATGGCAATGGCGGTCTTGTTTGCCTGTCTGATTGCCCGCGGGCTGTATCTGCAGACGGTAACGTATAACTTTTTGAAAGAACAGGGCGACAACCGGATTGTGCGGACTCAAGCATTGCCGGCTACACGCGGTACGGTTTCGGACCGGAACGGTGCGGTTTTGGCGTTGAGCGCGCCGACGGAGTCCCTGTTTGCCGTGCCTAAAGATATGAAGGAAATGCCGTCTGCCGCCCAATTGGAACGCCTGTCCGAGCTTGTCGATGTGCCGGTCGATGTTTTGAGGAACAAACTCGAACAGAAAGGCAAGTCGTTTATTTGGATCAAGCGGCAGCTCGATCCCAAGGTTGCCGAAGAGGTCAAAGCCTTGGGTTTGGAAAACTTTGTATTTGAAAAAGAATTAAAACGCCATTACCCGATGGGCAACCTGTTTGCACACGTCATCGGATTTACCGATATTGACGGCAAAGGTCAGGAAGGTTTGGAACTTTCGCTTGAAGACAGCCTGTATGGCGAAGACGGCGCGGAAGTTGTTTTGCGGGACCGGCAGGGCAATATTGTGGACAGCTTGGACTCCCCGCGCAATAAAGCACCGCAAAACGGCAAAGACATCATCCTTTCCCTCGATCAGAGGATTCAGACCTTGGCCTATGAAGAGTTGAACAAGGCGGTCGAATACCATCAGGCAAAAGCCGGAACGGTGGTGGTTTTGGATGCCCGCACGGGGGAAATCCTCGCCTTGGCCAATACGCCCGCCTACGATCCCAACAGACCCGGCCGGGCAGACAGCGAACAGCGGCGCAACCGTGCCGTAACCGATATGATCGAACCTGGTTCGGCAATCAAACCGTTCGTGATTGCGAAGGCATTGGATGCGGGCAAAACCGATTTGAACGAACGGCTGAATACGCAGCCTTATAAAATCGGACCGTCTCCCGTGCGCGATACCCATGTTTACCCCTCTTTGGATGTGCGCGGCATTATGCAGAAATCGTCCAACGTCGGCACAAGCAAACTGTCTGCGCGTTTCGGCGCCGAAGAAATGTATGACTTCTATCATGAATTGGGCATCGGTGTGCGTATGCACTCGGGCTTTCCGGGGGAAACTGCAGGTTTGTTGAGAAATTGGCGCAGGTGGCGGCCCATCGAACAGGCGACGATGTCTTTCGGTTACGGTCTGCAATTGAGCCTGCTGCAATTGGCGCGCGCCTATACCGCACTGACGCACGACGGCGTTTTGCTGCCGCTCAGCTTTGAGAAGCAGGCGGTTGCGCCGCAAGGCAAACGCATATTCAAAGAATCGACCGCGCGCGAGGTACGCAATCTGATGGTTTCCGTAACCGAGCCGGGCGGCACCGGTACGGCGGGTGCGGTGGACGGTTTCGATGTCGGCGCTAAAACCGGCACGGCGCGCAAGTTCGTCAACGGGCGTTATGCCGACAACAAACACGTCGCTACCTTTATCGGTTTTGCCCCCGCCAAAAACCCCCGTGTGATTGTGGCGGTAACCATCGACGAACCGACTGCCCACGGCTATTACGGCGGCGTAGTGGCAGGGCCGCCCTTCAAAAAAATTATGGGCGGCAGCCTGAACATCTTGGGCATTTCCCCGACCAAGCCACTGACCGCCGCAGCCGTCAAAACACCGTCTTAA UPDATED fmax with 1848 UPDATED accession with M32091.1 UPDATED fmin with 102 UPDATED strand with + UPDATED NCBI_taxonomy_name with Neisseria gonorrhoeae UPDATED NCBI_taxonomy_id with 485 UPDATED NCBI_taxonomy_cvterm_id with 36806 UPDATED accession with AAA25463.1 UPDATED sequence with MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAMAVLFACLIARGLYLQTVTYNFLKEQGDNRIVRTQALPATRGTVSDRNGAVLALSAPTESLFAVPKDMKEMPSAAQLERLSELVDVPVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLYGEDGAEVVLRDRQGNIVDSLDSPRNKAPQNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSLDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLARAYTALTHDGVLLPLSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHVATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS " 1438 UPDATE SHV-19 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1893 UPDATE SHV-127 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1817 UPDATE vgaB dalfopristin; virginiamycin M1; pleuromutilin antibiotic; vga-type ABC-F protein; streptogramin A antibiotic; antibiotic target protection; streptogramin antibiotic; ARO_category "DELETED 37716 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with vga-type ABC-F protein UPDATED category_aro_cvterm_id with 36252 UPDATED category_aro_accession with 3000113 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. " 2130 UPDATE opcM efflux pump complex or subunit conferring antibiotic resistance; fluoroquinolone antibiotic; aminoglycoside antibiotic; resistance-nodulation-cell division (RND) antibiotic efflux pump; antibiotic efflux; model_sequences "UPDATED partial with 1 " 950 UPDATE ErmX streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1612 UPDATE ErmR streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1194 UPDATE OXA-16 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with ATCGCGTGTCTTTCGAGTACGGCATTAGCTGGTTCAATTACAGAAAATACGTCTTGGAACAAAGAGTTCTCTGCCGAAGCCGTCAATGGTGTCTTCGTGCTTTGTAAAAGTAGCAGTAAATCCTGCGCTACCAATGACTTAGCTCGTGCATCAAAGGAATATCTTCCAGCATCAACATTTAAGATCCCCAACGCAATTATCGGCCTAGAAACTGGTGTCATAAAGAATGAGCATCAGGTTTTCAAATGGGACGGAAAGCCAAGAGCCATGAAGCAATGGGAAAGAGACTTGACCTTAAGAGGGGCAATACAAGTTTCAGCTGTTCCCGTATTTCAACAAATCACCAGAGAAGTTGGCGAAGTAAGAATGCAGAAATACCTTAAAAAATTTTCCTATGGCAACCAGAATATCAGTGGTGGCATTGACAAATTCTGGTTGGAAGACCAGCTTAGAATTTCCGCAGTTAATCAAGTGGAGTTTCTAGAGTCTCTATATTTAAATAAATTGTCAGCATCTAAAGAAAACCAGCTAATAGTAAAAGAGGCTTTGGTAACGGAGGCGGCACCTGAATATCTAGTGCATTCAAAAACTGGTTTTTCTGGTGTGGGAACTGAGTCAAATCCTGGTGTCGCATGGTGGGTTGGGTGGGTTGAGAAGGAGACAGAGGTTTACTTTTTCGCCTTTAACATGGATATAGACAACGAAAGTAAGTTGCCGCTAAGAAAATCCATTCCCACCAAAATCATGGAAAGTGAGGGCATCATTGGTGGCTAA UPDATED fmax with 775 UPDATED accession with AF043100.1 UPDATED fmin with 1 UPDATED strand with + UPDATED NCBI_taxonomy_name with Pseudomonas aeruginosa UPDATED NCBI_taxonomy_id with 287 UPDATED NCBI_taxonomy_cvterm_id with 36752 UPDATED accession with AAB97924.1 UPDATED sequence with IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQITREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG " 2036 UPDATE SHV-163 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1298 UPDATE lsaA dalfopristin; pleuromutilin; quinupristin; streptogramin B antibiotic; pleuromutilin antibiotic; lsa-type ABC-F protein; streptogramin A antibiotic; antibiotic target protection; streptogramin antibiotic; clindamycin; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. UPDATED category_aro_name with lsa-type ABC-F protein UPDATED category_aro_cvterm_id with 41696 UPDATED category_aro_accession with 3004472 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome. UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. " 3975 UPDATE SHV-202 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with GTGGTTAAGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCGGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGGATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA UPDATED fmax with 867 UPDATED accession with MF804906.1 UPDATED fmin with 0 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with WP_122630839.1 UPDATED sequence with MVKRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQRERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR " 1117 UPDATE ErmD streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 1292 UPDATE CTX-M-109 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with GTTAAAAAATCACTGCGTCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCGAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCAAA UPDATED fmax with 864 UPDATED accession with JF274248.1 UPDATED fmin with 0 UPDATED strand with - UPDATED NCBI_taxonomy_name with Shigella sp. SH361 UPDATED NCBI_taxonomy_id with 1074437 UPDATED NCBI_taxonomy_cvterm_id with 39658 UPDATED accession with AEM44654.1 UPDATED sequence with VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSRILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTK " 1293 UPDATE OXA-197 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 " 1753 UPDATE SHV-148 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1751 UPDATE Erm(33) streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 890 UPDATE SHV-53 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with ATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGATCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGCATTGTCGCCCTGCTTGGCCCGAATAAC UPDATED fmax with 727 UPDATED accession with AY590467.1 UPDATED fmin with 1 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella pneumoniae UPDATED NCBI_taxonomy_id with 573 UPDATED NCBI_taxonomy_cvterm_id with 35915 UPDATED accession with AAT01223.1 UPDATED sequence with IISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLISQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNN " 200 UPDATE LEN-14 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences "UPDATED partial with 1 UPDATED sequence with TCCCTGTTAGCCACCCTGCCACTGGCGGTATACGCCGGTCCACAGCCGCTTGAGCAGATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTGGGGATGGTGGAAATGGATCTGGCCAGCGGCCGCACGCTGGCGGCCTGGCGCGCCGATGAACGCTTTCCCATGGTGAGCACCTTTAAAGTGCTGCTGTGCGGCGCGGTGCTGGCGCGGGTGGATGCCGGGCTCGAACAACTGGATCGGCGGATCCACTACCGCCAGCAGGATCTGGTGGACTACTCCCCGGTCAGCGAAAAACACCTTACCGACGGGATGACGATCGGCGAACTCTGCGCCGCCGCCATCACCCTGAGCGATAACTGCGCTGGCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCGGGATTAACTGCCTTTCTGCGCCAGATCGGTGACAACGTCACCCGTCTTGACCGCTGG UPDATED fmax with 458 UPDATED accession with AY265889.1 UPDATED fmin with 2 UPDATED strand with + UPDATED NCBI_taxonomy_name with Enterobacter cloacae UPDATED NCBI_taxonomy_id with 550 UPDATED NCBI_taxonomy_cvterm_id with 36884 UPDATED accession with AAP93847.1 UPDATED sequence with SLLATLPLAVYAGPQPLEQIKQSESQLSGRVGMVEMDLASGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLTDGMTIGELCAAAITLSDNCAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRW " 1172 UPDATE OXA-194 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 " 772 UPDATE LEN-6 penam; LEN beta-lactamase; antibiotic inactivation; penem; model_sequences "UPDATED partial with 1 " 1270 UPDATE QnrS3 sparfloxacin; norfloxacin; quinolone resistance protein (qnr); gatifloxacin; levofloxacin; antibiotic target protection; ciprofloxacin; fluoroquinolone antibiotic; nalidixic acid; moxifloxacin; model_sequences "UPDATED partial with 1 UPDATED sequence with GAAACCTACAATCATACATATCGGCACCGCAACTTTTCACATAAAGACTTAAGTGATCTCACCTTCACCGCTTGCACATTCATTCGCAGCGACTTTCGACGTGCTAACTTGCGTGATACGACATTCGTCAACTGCAAGTTCATTGAACAGGGTGATATCGAAGGCTGCCACTTTGATGTCGCAGATCTTCGTGATGCAAGTTTCCAACAATGCCAACTTGCGATGGCAAACTTCAGTAATGCCAATTGCTACGGTATAGAGTTCCGTGCGTGTGATTTAAAAGGTGCCAACTTTTCCCGAACAAACTTTGCCCATCAAGTGAGTAATCGTATGTACTTTTGCTCAGCATTTATTTCTGGATGTAATCTTTCCTATGCCAATATGGAGAGGGTTTGTTTAGAAAAATGTGAGTTGTTTGAAAATCGCTGGATAGGAACGAACCTAGCGGGTGCATCACTGAAAGAGTCAGACTTAAGTCGAGGTGTTTTTTCCGAAGATGTCTGGGGGCAATTTAGCCTACAGGGTGCCAATTTATGCCACGCCGAACTCGACGGTTTAGATCCCCGCAAAGTCGATACATCAGGTATCAAAATTGCAGCCTGGCAGCAAGAACTGATTCTCGAAGCACTGGGTATTGTTGTTTATCCTGACTAA UPDATED fmax with 656 UPDATED accession with EU077611.1 UPDATED fmin with 2 UPDATED strand with + UPDATED NCBI_taxonomy_name with Escherichia coli UPDATED NCBI_taxonomy_id with 562 UPDATED NCBI_taxonomy_cvterm_id with 35914 UPDATED accession with ABU52984.1 UPDATED sequence with ETYNHTYRHRNFSHKDLSDLTFTACTFIRSDFRRANLRDTTFVNCKFIEQGDIEGCHFDVADLRDASFQQCQLAMANFSNANCYGIEFRACDLKGANFSRTNFAHQVSNRMYFCSAFISGCNLSYANMERVCLEKCELFENRWIGTNLAGASLKESDLSRGVFSEDVWGQFSLQGANLCHAELDGLDPRKVDTSGIKIAAWQQELILEALGIVVYPD " 610 UPDATE SHV-153 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1275 UPDATE ErmT streptogramin A antibiotic; antibiotic target alteration; virginiamycin S2; vernamycin C; pristinamycin IC; patricin B; patricin A; oleandomycin; ostreogrycin B3; macrolide antibiotic; telithromycin; tylosin; lincosamide antibiotic; dirithromycin; clarithromycin; clindamycin; dalfopristin; pristinamycin IB; quinupristin; pristinamycin IA; Erm 23S ribosomal RNA methyltransferase; virginiamycin M1; madumycin II; griseoviridin; streptogramin B antibiotic; lincomycin; streptogramin antibiotic; roxithromycin; spiramycin; azithromycin; erythromycin; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with streptogramin B antibiotic UPDATED category_aro_cvterm_id with 35967 UPDATED category_aro_accession with 0000050 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. " 5737 UPDATE salB retapamulin; sal-type ABC-F protein; virginiamycin M1; pleuromutilin antibiotic; tiamulin; streptogramin A antibiotic; lincomycin; antibiotic target protection; streptogramin antibiotic; clindamycin; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with sal-type ABC-F protein UPDATED category_aro_cvterm_id with 45589 UPDATED category_aro_accession with 3007030 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. " 486 UPDATE cmlB antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; phenicol antibiotic; chloramphenicol; model_sequences "UPDATED partial with 0 UPDATED sequence with GTGCGCTCAAAGAACTGTAATTGGCGGTATTCCCTTGCCGTCACTGTGTTGTTGTTATCACCTTTCGATTTACTGGCATCACTCGGCATGGACATGTACTTGCCAGCGGTGCCTTTCATGCCACATGCTCTTGGTACGACAGCGGGCACAATTCAGCTTACGCTGACAACGTATTTGGTCATGATAGGGGCCGGTCAGCTTTTGTTTGGGCCACTGTCGGACCGGCTGGGACGTCGTCCCGTGCTACTGGCGGGCGGTGCCGCCTACGTTGCGGCCTCAATCGGCCTCGTCGTCACGTCATCGGCTGGAGTATTTCTGGGTTTTCGGATTCTCCAAGCTTGTGGTGCCTCGGCATGCCTTGTTGCCACATTTGCAACAGTGCGTGATATCTACGCAGGTCGCAAGGAAAGTAACGTCATCTACGGCTTGCTTGGCTCTATGCTTGCTATGGTTCCGGCGATAGGCCCATTGCTGGGAGCGGTCATAGACACCTGGTTCGGGTGGCGGGCGATCTTTGCGTTCTTGGGATTGGGAATGATCGCTGCATTGACAGCAGCGTGGCGGCTCTGGCCTGAGACCCGGGTGCAGCGACCAGCAGCTTTGCAATGGTCACAACTTCTGCTTCCCATCAAGCACCTTAACTTCTGGTTGTACACAGTGTGTTATGCCGCAGGAATGGGCAGCTTCTTCGTCTTCTTCTCCATAGCGCCCGGATTGATGATGGGTAGGCAAGGCATGTCCCAGTTTGGCTTCAGTCTGTTGTTCGCAACAGTGGCAATTGCGATGATGCTTGCGGCCCGCTTCATGGGGCGCGTAATCGCCAAGTGGGGCAGCCTGAGTGCCTTGCGAATGGGGATGGGCTGCCTGATAGCAGGCGCAGTCTTGCTTGTCATCACCGAGCTATGGATTCCGCAGTCCGTGTTGGGCTTTATTGCCCCAATGTGGCTAGTGGGCGTCGGCGTCGCGACAGCGGTATCCGTTGCACCCAATGGTGCGCTTCGAGGGTTCGACCATATTGCAGGAGCCGTTACGGCAGTCTACTTCTGCTTGGGGGGGCTGCTGCTGGGGAGTGTTGGAACGCTCATCATTTCGCTGTTGCCGCGCGACACGGCCTGGCCAGTTATCGCGTATTGTTTGGTTCTTGCAACAATCGTGCTTGGACTGTCGTGTGTTTCCCGAGCGAGAGACCTTCGCGGTCACGGGGAGTATGATGCGGTTGCACGCACATAG UPDATED fmax with 3871 UPDATED accession with AF034958.3 UPDATED fmin with 2641 UPDATED strand with + UPDATED NCBI_taxonomy_name with Klebsiella aerogenes UPDATED NCBI_taxonomy_id with 548 UPDATED NCBI_taxonomy_cvterm_id with 36770 UPDATED accession with AAD22144.1 UPDATED sequence with MRSKNCNWRYSLAVTVLLLSPFDLLASLGMDMYLPAVPFMPHALGTTAGTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLAGGAAYVAASIGLVVTSSAGVFLGFRILQACGASACLVATFATVRDIYAGRKESNVIYGLLGSMLAMVPAIGPLLGAVIDTWFGWRAIFAFLGLGMIAALTAAWRLWPETRVQRPAALQWSQLLLPIKHLNFWLYTVCYAAGMGSFFVFFSIAPGLMMGRQGMSQFGFSLLFATVAIAMMLAARFMGRVIAKWGSLSALRMGMGCLIAGAVLLVITELWIPQSVLGFIAPMWLVGVGVATAVSVAPNGALRGFDHIAGAVTAVYFCLGGLLLGSVGTLIISLLPRDTAWPVIAYCLVLATIVLGLSCVSRARDLRGHGEYDAVART " 5739 UPDATE salD retapamulin; sal-type ABC-F protein; virginiamycin M1; pleuromutilin antibiotic; tiamulin; streptogramin A antibiotic; lincomycin; antibiotic target protection; streptogramin antibiotic; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with sal-type ABC-F protein UPDATED category_aro_cvterm_id with 45589 UPDATED category_aro_accession with 3007030 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. " 5738 UPDATE salC retapamulin; sal-type ABC-F protein; virginiamycin M1; pleuromutilin antibiotic; tiamulin; streptogramin A antibiotic; lincomycin; antibiotic target protection; streptogramin antibiotic; clindamycin; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with sal-type ABC-F protein UPDATED category_aro_cvterm_id with 45589 UPDATED category_aro_accession with 3007030 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. " 1287 UPDATE CTX-M-110 antibiotic inactivation; cephalosporin; CTX-M beta-lactamase; model_sequences "UPDATED partial with 1 " 4061 UPDATE OXA-673 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGATCATGTCGAAAAAATTAACATGTCTGGCCCTGTTTACAGCCATCTTTTTTGCGATTCCCATGGCCGCTTGTCAAAGTTTTAGTCAACAAAAGCAACAGCTTTCGACACAGAAAAATGAACAGCAACAGATTTCAAGCTTATTTCAGAGTGCCCAAACCAGTGGTGTTTTGGTGATTTATGATGGCAAGAAAATTCAAAGCTATGGCAATGATCTTGATCGTGCAGAACAGCGCTATATTCCTGCCTCAACCTTTAAAATGTTAAACGCCTTGATCGGCATACAGCATCATAAGACCACACCAGATGAAGTGTTTAAATGGGATGGTAAAAAGCGGGCATTCAGCAGTTGGGAAAAAGATTTAACCTTGGCTGAAGCCATGCAGGCATCGGCGGTACCTGTCTATCAGGAATTGGCACGACGTATTGGCTTAGAACTGATGACCCGTGAAGTGAAGCGTGTAGGTTATGGCAATAAAAATATCGGGACGCAAGTTGATACTTTCTGGTTGGTTGGCCCATTAAAAATCACCCCCGTAGAAGAAGTTCGCTTTGCCTATGCATTGGCAAAACAGAAGCTGCCATTTGACCAGCCAACGCAGCAACAAGTCAAAGCGATGTTATTGGTGGATCAGATTCAGGGAACTAAAATCTATGCCAAAAGTGGTTGGGGCATGGATGTTAGCCCTCAAGTGGGGTGGTTGACAGGCTGGATTGAACAGCCAAACGGTAAGATCACTGCCTTCTCGCTCAATATGCAAATGAGTCAGCCTGAACATGCAGATGCACGCAAAGTGATTGTGTATCAAGCCTTGCAACAGTTGGGATTGTTAGCCCATTAA UPDATED fmax with 297289 UPDATED accession with AQFL01000004.1 UPDATED fmin with 296446 UPDATED strand with - UPDATED NCBI_taxonomy_name with unclassified Acinetobacter UPDATED NCBI_taxonomy_id with 196816 UPDATED NCBI_taxonomy_cvterm_id with 45627 UPDATED accession with WP_016162389.1 UPDATED sequence with MIMSKKLTCLALFTAIFFAIPMAACQSFSQQKQQLSTQKNEQQQISSLFQSAQTSGVLVIYDGKKIQSYGNDLDRAEQRYIPASTFKMLNALIGIQHHKTTPDEVFKWDGKKRAFSSWEKDLTLAEAMQASAVPVYQELARRIGLELMTREVKRVGYGNKNIGTQVDTFWLVGPLKITPVEEVRFAYALAKQKLPFDQPTQQQVKAMLLVDQIQGTKIYAKSGWGMDVSPQVGWLTGWIEQPNGKITAFSLNMQMSQPEHADARKVIVYQALQQLGLLAH " 1046 UPDATE vgaD streptogramin antibiotic; pleuromutilin antibiotic; streptogramin A antibiotic; antibiotic target protection; vga-type ABC-F protein; ARO_category "DELETED 37018 UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. UPDATED category_aro_name with vga-type ABC-F protein UPDATED category_aro_cvterm_id with 36252 UPDATED category_aro_accession with 3000113 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. " 942 UPDATE OXA-104 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 " 1578 UPDATE SHV-123 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1476 UPDATE TEM-199 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; model_sequences "UPDATED partial with 1 UPDATED sequence with CAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATAAGTTGGGTGCACGAGTGGGTTACATCGAGCTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGTGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTAAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATTGGGGATCATGTAACCCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCAGTGAGCGTGGATCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA UPDATED fmax with 853 UPDATED accession with JX050178.1 UPDATED fmin with 1 UPDATED strand with + UPDATED NCBI_taxonomy_name with Proteus mirabilis UPDATED NCBI_taxonomy_id with 584 UPDATED NCBI_taxonomy_cvterm_id with 36771 UPDATED accession with AFN69127.1 UPDATED sequence with QHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNIGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW " 351 UPDATE SHV-6 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1686 UPDATE OXA-34 carbapenem; penam; cephalosporin; antibiotic inactivation; OXA beta-lactamase; model_sequences "UPDATED partial with 1 " 264 UPDATE lsaE pleuromutilin; pleuromutilin antibiotic; lsa-type ABC-F protein; lincomycin; antibiotic target protection; streptogramin antibiotic; lincosamide antibiotic; ARO_category "DELETED 36189 UPDATED category_aro_name with lsa-type ABC-F protein UPDATED category_aro_cvterm_id with 41696 UPDATED category_aro_accession with 3004472 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome. " 806 UPDATE SHV-150 carbapenem; penam; cephalosporin; antibiotic inactivation; SHV beta-lactamase; model_sequences "UPDATED partial with 1 " 1642 UPDATE clbC dalfopristin; thiamphenicol; oxazolidinone antibiotic; virginiamycin M1; pleuromutilin antibiotic; tiamulin; madumycin II; griseoviridin; streptogramin A antibiotic; lincomycin; streptogramin antibiotic; antibiotic target alteration; lincosamide antibiotic; azidamfenicol; clindamycin; phenicol antibiotic; Cfr 23S ribosomal RNA methyltransferase; chloramphenicol; ARO_category "UPDATED category_aro_name with streptogramin A antibiotic UPDATED category_aro_cvterm_id with 35952 UPDATED category_aro_accession with 0000034 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. "