Model_id Action ARO_name ARO_category Changes To Summary 3783 UPDATE YajC glycopeptide antibiotic; tetracycline antibiotic; antibiotic efflux; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; cephalosporin; cefalotin; disinfecting agents and antiseptics; linezolid; ampicillin; oxazolidinone antibiotic; chloramphenicol; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; fluoroquinolone antibiotic; vancomycin; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_name with glycopeptide antibiotic UPDATED category_aro_cvterm_id with 36220 UPDATED category_aro_accession with 3000081 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria. This inhibits transglycosylation leading to cell death due to osmotic stress. UPDATED category_aro_name with linezolid UPDATED category_aro_cvterm_id with 35989 UPDATED category_aro_accession with 0000072 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. UPDATED category_aro_name with vancomycin UPDATED category_aro_cvterm_id with 35947 UPDATED category_aro_accession with 0000028 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin inhibits the synthesis of peptidoglycan, the major component of the cell wall of gram-positive bacteria. Its mechanism of action is unusual in that it acts by binding precursors of peptidoglycan, rather than by interacting with an enzyme. UPDATED category_aro_name with oxazolidinone antibiotic UPDATED category_aro_cvterm_id with 36218 UPDATED category_aro_accession with 3000079 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. " 1643 UPDATE arnA pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; polymyxin B; ARO_category "DELETED 36001 " 3804 UPDATE cprS antibiotic efflux; colistin B; polymyxin B; protein(s) and two-component regulatory system modulating antibiotic efflux; pmr phosphoethanolamine transferase; colistin A; peptide antibiotic; antibiotic target alteration; ARO_category "UPDATED category_aro_name with colistin B UPDATED category_aro_cvterm_id with 36968 UPDATED category_aro_accession with 3000624 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. UPDATED category_aro_name with polymyxin B UPDATED category_aro_cvterm_id with 36593 UPDATED category_aro_accession with 3000454 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Polymyxin B is mixture of mostly polymyxins B1 and B2, mainly used for resistant gram-negative infections. They are polypeptides with cationic detergent action on cell membranes. UPDATED category_aro_name with colistin A UPDATED category_aro_cvterm_id with 36966 UPDATED category_aro_accession with 3000622 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. " 5758 UPDATE Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin penam; cephamycin; cephalosporin; Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; antibiotic target alteration; amoxicillin; model_param "DELETED 12550 DELETED 12550 UPDATED 12712 with +E464-465 UPDATED 12713 with +N464-465 UPDATED 12716 with +A595-596 UPDATED 12714 with +G595-596 UPDATED 12715 with +S595-596 UPDATED param_type_id with 41340 UPDATED param_type with insertion mutation UPDATED param_description with A detection model parameter to describe a set of mapped insertion mutations. A insertion mutation refers to the addition of one or more nucleotides to a DNA strand. In publications, insertion mutations may be reported in nucleotide or in peptide format. Insertion mutations not of a multiple of 3 cause frameshifts in the nucleotide open reading frame. However, the insertion mutation parameter only refers to insertions which modify the peptide sequence and/or change its function, but do not result in premature termination or functional protein knockout. " 3803 UPDATE cprR antibiotic efflux; colistin B; polymyxin B; protein(s) and two-component regulatory system modulating antibiotic efflux; pmr phosphoethanolamine transferase; colistin A; peptide antibiotic; antibiotic target alteration; ARO_category "UPDATED category_aro_name with colistin B UPDATED category_aro_cvterm_id with 36968 UPDATED category_aro_accession with 3000624 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. UPDATED category_aro_name with polymyxin B UPDATED category_aro_cvterm_id with 36593 UPDATED category_aro_accession with 3000454 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Polymyxin B is mixture of mostly polymyxins B1 and B2, mainly used for resistant gram-negative infections. They are polypeptides with cationic detergent action on cell membranes. UPDATED category_aro_name with colistin A UPDATED category_aro_cvterm_id with 36966 UPDATED category_aro_accession with 3000622 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. " 5712 UPDATE VIM-63 penam; carbapenem; imipenem; penem; faropenem; cephalosporin; cefotaxime; ceftazidime; cefepime; cephamycin; antibiotic inactivation; ampicillin; VIM beta-lactamase; ertapenem; meropenem; ARO_category "UPDATED category_aro_name with imipenem UPDATED category_aro_cvterm_id with 36309 UPDATED category_aro_accession with 3000170 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes. UPDATED category_aro_name with faropenem UPDATED category_aro_cvterm_id with 40361 UPDATED category_aro_accession with 3003707 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Faropenem is an orally active beta-lactam antibiotic belonging to the penem group. UPDATED category_aro_name with cefotaxime UPDATED category_aro_cvterm_id with 36989 UPDATED category_aro_accession with 3000645 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups. UPDATED category_aro_name with ceftazidime UPDATED category_aro_cvterm_id with 35977 UPDATED category_aro_accession with 0000060 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. UPDATED category_aro_name with cefepime UPDATED category_aro_cvterm_id with 35976 UPDATED category_aro_accession with 0000059 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. UPDATED category_aro_name with meropenem UPDATED category_aro_cvterm_id with 35990 UPDATED category_aro_accession with 0000073 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. UPDATED category_aro_name with ertapenem UPDATED category_aro_cvterm_id with 35987 UPDATED category_aro_accession with 0000070 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis. " 2743 UPDATE Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime tetracycline antibiotic; antibiotic target alteration; antibiotic efflux; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; ceftazidime; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_name with ceftazidime UPDATED category_aro_cvterm_id with 35977 UPDATED category_aro_accession with 0000060 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. UPDATED category_aro_name with ciprofloxacin UPDATED category_aro_cvterm_id with 35954 UPDATED category_aro_accession with 0000036 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. " 3658 UPDATE NDM-16 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; ARO_description; CARD_short_name; model_name; ARO_name "UPDATED ARO_description with New Delhi class B metallo-beta-lactamase-16a variant of NDM-1. UPDATED CARD_short_name with NDM-16a UPDATED model_name with NDM-16a UPDATED ARO_name with NDM-16a " 2744 UPDATE Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ciprofloxacin; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_name with ciprofloxacin UPDATED category_aro_cvterm_id with 35954 UPDATED category_aro_accession with 0000036 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. " 2660 UPDATE Enterobacter cloacae acrA penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_description "UPDATED ARO_description with AcrA is a subunit of the AcrAB-TolC multidrug efflux system in E. cloacae. " 2092 UPDATE Klebsiella aerogenes acrR with mutation conferring multidrug antibiotic resistance antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; tigecycline; protein(s) and two-component regulatory system modulating antibiotic efflux; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; acriflavine; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category; model_name; ARO_name "UPDATED category_aro_name with norfloxacin UPDATED category_aro_cvterm_id with 37006 UPDATED category_aro_accession with 3000662 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes. UPDATED category_aro_name with acriflavine UPDATED category_aro_cvterm_id with 35963 UPDATED category_aro_accession with 0000045 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish. UPDATED category_aro_name with ciprofloxacin UPDATED category_aro_cvterm_id with 35954 UPDATED category_aro_accession with 0000036 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. UPDATED model_name with Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance UPDATED ARO_name with Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance " 1894 UPDATE Salmonella enterica ramR mutants penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ciprofloxacin; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_name with ciprofloxacin UPDATED category_aro_cvterm_id with 35954 UPDATED category_aro_accession with 0000036 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. " 2014 UPDATE PmrF pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; polymyxin B; ARO_category "DELETED 36001 " 1005 UPDATE Escherichia coli soxR with mutation conferring antibiotic resistance antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; nalidixic acid; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_name with nalidixic acid UPDATED category_aro_cvterm_id with 37005 UPDATED category_aro_accession with 3000661 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments. " 2306 UPDATE Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime tetracycline antibiotic; antibiotic target alteration; antibiotic efflux; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; ceftazidime; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; ARO_category "UPDATED category_aro_name with ceftazidime UPDATED category_aro_cvterm_id with 35977 UPDATED category_aro_accession with 0000060 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. UPDATED category_aro_name with ciprofloxacin UPDATED category_aro_cvterm_id with 35954 UPDATED category_aro_accession with 0000036 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. " 2066 UPDATE Escherichia coli soxS with mutation conferring antibiotic resistance penem; antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; reduced permeability to antibiotic; carbapenem; cephalosporin; cefalotin; ciprofloxacin; enrofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; tigecycline; glycylcycline; General Bacterial Porin with reduced permeability to beta-lactams; monobactam; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_name with enrofloxacin UPDATED category_aro_cvterm_id with 45604 UPDATED category_aro_accession with 3007045 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Enrofloxacin is a board-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats but is sometimes used for other animals. " 431 UPDATE Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline penam; antibiotic efflux; triclosan; rifampin; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; disinfecting agents and antiseptics; tetracycline antibiotic; cephalosporin; cefalotin; tigecycline; glycylcycline; ciprofloxacin; ampicillin; fluoroquinolone antibiotic; rifamycin antibiotic; phenicol antibiotic; tetracycline; chloramphenicol; ARO_category "UPDATED category_aro_name with ciprofloxacin UPDATED category_aro_cvterm_id with 35954 UPDATED category_aro_accession with 0000036 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. " 5821 ADD Nocardia farcinica rox antibiotic inactivation; rifampin monooxygenase; rifampin; rifamycin antibiotic; N/A N/A 5820 ADD Streptomyces venezuelae rox antibiotic inactivation; rifampin monooxygenase; rifampin; rifapentine; rifaximin; rifamycin antibiotic; N/A N/A 5823 ADD NDM-35 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5822 ADD NDM-34 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5825 ADD NDM-37 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5827 ADD NDM-39 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5830 ADD NDM-42 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5831 ADD NDM-43 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5829 ADD NDM-41 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5828 ADD NDM-40 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5826 ADD NDM-38 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5818 ADD KBL-1 penam; antibiotic inactivation; KBL beta-lactamase; benzylpenicillin; ampicillin; amoxicillin; piperacillin; N/A N/A 5819 ADD HelR rifampin; rifabutin; helicase-like RNA polymerase protection protein; antibiotic target protection; rifaximin; rifamycin antibiotic; N/A N/A 5824 ADD NDM-36 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5811 ADD KPC-123 penam; carbapenem; avibactam; ceftazidime-avibactam; cephalosporin; cefotaxime; ceftazidime; cefepime; antibiotic inactivation; monobactam; KPC beta-lactamase; N/A N/A 5812 ADD PAM-1 antibiotic inactivation; PAM beta-lactamase; cephalosporin; carbapenem; ceftazidime; doripenem; N/A N/A 5813 ADD PAM-2 carbapenem; antibiotic inactivation; ceftazidime; PAM beta-lactamase; cephalosporin; N/A N/A 5814 ADD PAM-3 carbapenem; antibiotic inactivation; cephalosporin; PAM beta-lactamase; N/A N/A 5815 ADD NDM-16b antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5816 ADD Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; colistin B; polymyxin B; protein(s) and two-component regulatory system modulating antibiotic efflux; pmr phosphoethanolamine transferase; colistin A; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; resistance by absence; erythromycin; N/A N/A 5817 ADD AAC(6')-Iap antibiotic inactivation; kanamycin A; gentamicin A; AAC(6'); aminoglycoside antibiotic; sisomicin; arbekacin; netilmicin; amikacin; dibekacin; neomycin; tobramycin; N/A N/A