Model_id Action ARO_name ARO_category Changes To Summary 2079 UPDATE sgm kanamycin A; aminoglycoside antibiotic; isepamicin; gentamicin; 16S rRNA methyltransferase (G1405); sisomicin; arbekacin; gentamicin B; netilmicin; antibiotic target alteration; gentamicin C; amikacin; dibekacin; G418; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 3856 UPDATE OXA-846 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 343 UPDATE OXA-31 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 813 UPDATE OXA-216 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3494 UPDATE OXA-409 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 816 UPDATE OXA-3 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2910 UPDATE OXA-665 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4839 UPDATE OXA-504 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2912 UPDATE OXA-274 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1260 UPDATE APH(3')-IVa antibiotic inactivation; aminoglycoside antibiotic; paromomycin; kanamycin A; APH(3'); ribostamycin; neomycin; butirosin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36999 " 4969 UPDATE OXA-644 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 965 UPDATE OXA-333 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 715 UPDATE PDC-3 penam; carbapenem; cephalosporin; cefazolin; ampicillin; ceftazidime; cefalotin; cephamycin; antibiotic inactivation; PDC beta-lactamase; monobactam; cefixime; ceftriaxone; cefoxitin; ARO_category "DELETED 40951 " 967 UPDATE AAC(6')-Isa 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 5180 UPDATE OXA-883 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1266 UPDATE ANT(4')-IIa antibiotic inactivation; isepamicin; ANT(4'); amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 4'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 4-hydroxyl group of the compound. DELETED 37001 " 1327 UPDATE AAC(6')-Iq 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 2072 UPDATE NmcR penam; carbapenem; NmcA beta-lactamase; cefazolin; cephalosporin; antibiotic inactivation; cephamycin; ampicillin; cefoxitin; ARO_category "DELETED 35981 " 5181 UPDATE OXA-884 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1496 UPDATE OXA-224 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3334 UPDATE AAC(6')-Il 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 1995 UPDATE AAC(6')-Iz 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 3338 UPDATE AAC(6')-Iag 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 2178 UPDATE glycopeptide resistance gene cluster VanO glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vancomycin; model_description "UPDATED model_description with Gene Cluster Meta-Models (GCM) are used to curate spatial clusters of individual genes within operons, such as for glycopeptide resistance gene clusters. The individual genes will have their own individual detection models (e.g. PHM, PVM, POM, etc.) while the GCM checks to see if all the component genes of the cluster have a Strict or Perfect hit and are ordered correctly within an operon. GCMs are encoded using the gene order parameter. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software. " 4935 UPDATE OXA-609 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3485 UPDATE OXA-392 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1068 UPDATE AAC(6')-Ib3 antibiotic inactivation; AAC(6'); kanamycin A; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 1703 UPDATE FosK fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; phosphonic acid antibiotic; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 4936 UPDATE OXA-610 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1706 UPDATE OXA-142 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1361 UPDATE OXA-223 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5232 UPDATE OXA-948 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1065 UPDATE OXA-384 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4962 UPDATE OXA-636 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4075 UPDATE OXA-499 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2184 UPDATE glycopeptide resistance gene cluster VanC glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vancomycin; model_description "UPDATED model_description with Gene Cluster Meta-Models (GCM) are used to curate spatial clusters of individual genes within operons, such as for glycopeptide resistance gene clusters. The individual genes will have their own individual detection models (e.g. PHM, PVM, POM, etc.) while the GCM checks to see if all the component genes of the cluster have a Strict or Perfect hit and are ordered correctly within an operon. GCMs are encoded using the gene order parameter. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software. " 1258 UPDATE OXA-55 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5222 UPDATE OXA-937 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 295 UPDATE OXA-145 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5221 UPDATE OXA-935 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 291 UPDATE APH(3')-Ia antibiotic inactivation; aminoglycoside antibiotic; gentamicin; lividomycin; paromomycin; kanamycin A; APH(3'); gentamicin B; ribostamycin; neomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 UPDATED category_aro_name with gentamicin B UPDATED category_aro_cvterm_id with 36999 UPDATED category_aro_accession with 3000655 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin B is a semisynthetic aminoglycoside antibacterial. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with lividomycin UPDATED category_aro_cvterm_id with 37002 UPDATED category_aro_accession with 3000658 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. " 1128 UPDATE OXA-23 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5189 UPDATE OXA-892 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1083 UPDATE OXA-323 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1121 UPDATE APH(3')-VIa antibiotic inactivation; aminoglycoside antibiotic; isepamicin; gentamicin; paromomycin; kanamycin A; APH(3'); gentamicin B; amikacin; ribostamycin; neomycin; butirosin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 3779 UPDATE Yrc-1 penam; antibiotic inactivation; cephalosporin; cefoxitin; ceftazidime; cefalotin; cephamycin; cefuroxime; amoxicillin; YRC Beta-lactamase; ARO_category "UPDATED category_aro_name with ceftazidime UPDATED category_aro_cvterm_id with 35977 UPDATED category_aro_accession with 0000060 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with cephamycin UPDATED category_aro_cvterm_id with 35962 UPDATED category_aro_accession with 0000044 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases. UPDATED category_aro_name with cefuroxime UPDATED category_aro_cvterm_id with 35980 UPDATED category_aro_accession with 0000063 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefuroxime is a second-generation cephalosporin antibiotic with increased stability with beta-lactamases than first-generation cephalosporins. Cefuroxime is active against Gram-positive organisms but less active against methicillin-resistant strains. UPDATED category_aro_name with amoxicillin UPDATED category_aro_cvterm_id with 35981 UPDATED category_aro_accession with 0000064 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. UPDATED category_aro_name with cefoxitin UPDATED category_aro_cvterm_id with 35927 UPDATED category_aro_accession with 0000008 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. " 5084 UPDATE OXA-775 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 191 UPDATE OXA-199 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 190 UPDATE OXA-195 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1126 UPDATE OXA-184 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4070 UPDATE OXA-648 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5028 UPDATE OXA-716 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 274 UPDATE OXA-174 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5225 UPDATE OXA-940 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4072 UPDATE OXA-649 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1413 UPDATE OXA-172 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4930 UPDATE OXA-604 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3382 UPDATE aadS antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 6-hydroxyl group of the compound. " 3381 UPDATE aadA27 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 48 UPDATE OXA-90 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 922 UPDATE AAC(6')-30/AAC(6')-Ib' fusion protein antibiotic inactivation; aminoglycoside antibiotic; aminoglycoside bifunctional resistance protein; gentamicin; gentamicin A; ARO_category; model_name; ARO_name "DELETED 36484 UPDATED category_aro_name with aminoglycoside bifunctional resistance protein UPDATED category_aro_cvterm_id with 46171 UPDATED category_aro_accession with 3007419 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Bifunctional aminoglycoside-inactivating enzymes composed of two separate functional domains. These proteins possess activity from both enzyme components, thereby conferring resistance to the combination of antibiotics from both domains, and may include acetylation, phosphorylation or nucleotidylation activity. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED model_name with AAC(6')-30/AAC(6')-Ib' bifunctional protein UPDATED ARO_name with AAC(6')-30/AAC(6')-Ib' bifunctional protein " 2383 UPDATE ANT(4')-Ib antibiotic inactivation; tobramycin; dibekacin; ANT(4'); amikacin; isepamicin; aminoglycoside antibiotic; ARO_description; ARO_category "UPDATED ARO_description with Aminoglycoside nucleotidyltransferase sequence from Staphylococcus aureus plasmid. UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 4'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 4-hydroxyl group of the compound. DELETED 37001 UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1018 UPDATE APH(3')-IIc antibiotic inactivation; aminoglycoside antibiotic; gentamicin; paromomycin; kanamycin A; APH(3'); gentamicin B; ribostamycin; neomycin; butirosin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 521 UPDATE OXA-386 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 426 UPDATE aadK antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); ARO_description; ARO_category "UPDATED ARO_description with aadK is a chromosomal-encoded aminoglycoside nucleotidyltransferase gene in B. subtilis and Bacillus spp. This enzyme confers low-level resistance to streptomycin. UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 6-hydroxyl group of the compound. " 523 UPDATE OXA-75 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1403 UPDATE OXA-388 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1402 UPDATE OXA-390 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1016 UPDATE OXA-255 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1406 UPDATE OXA-121 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1405 UPDATE armA kanamycin A; aminoglycoside antibiotic; isepamicin; gentamicin; 16S rRNA methyltransferase (G1405); sisomicin; arbekacin; gentamicin B; netilmicin; antibiotic target alteration; gentamicin C; amikacin; dibekacin; G418; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1013 UPDATE APH(2'')-IIIa antibiotic inactivation; gentamicin; kanamycin A; APH(2''); amikacin; aminoglycoside antibiotic; gentamicin A; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 35953 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 5003 UPDATE OXA-691 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1235 UPDATE AAC(6')-Ib' AAC(6'); antibiotic inactivation; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 5001 UPDATE OXA-689 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5000 UPDATE OXA-688 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5007 UPDATE OXA-695 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5006 UPDATE OXA-694 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5005 UPDATE OXA-693 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2524 UPDATE AAC(2')-IIb antibiotic inactivation; aminoglycoside antibiotic; AAC(2'); kasugamycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound. " 5009 UPDATE OXA-697 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5008 UPDATE OXA-696 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1238 UPDATE OXA-397 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1332 UPDATE APH(3')-IIIa antibiotic inactivation; aminoglycoside antibiotic; isepamicin; gentamicin; lividomycin; paromomycin; kanamycin A; APH(3'); gentamicin B; amikacin; ribostamycin; neomycin; butirosin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with isepamicin UPDATED category_aro_cvterm_id with 36996 UPDATED category_aro_accession with 3000652 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae. UPDATED category_aro_name with lividomycin UPDATED category_aro_cvterm_id with 37002 UPDATED category_aro_accession with 3000658 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. " 5770 UPDATE KPC-90 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "DELETED 35977 " 104 UPDATE OXA-61 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5776 UPDATE KPC-93 antibiotic inactivation; penam; carbapenem; cephalosporin; monobactam; KPC beta-lactamase; ARO_category "DELETED 35977 " 4813 UPDATE OXA-114m penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2047 UPDATE OXA-322 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 39 UPDATE AAC(3)-Ia antibiotic inactivation; AAC(3); gentamicin; sisomicin; astromicin; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. DELETED 35933 UPDATED category_aro_name with astromicin UPDATED category_aro_cvterm_id with 35922 UPDATED category_aro_accession with 0000003 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Astromicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Astromicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 4810 UPDATE OXA-114j penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4817 UPDATE OXA-114r penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2043 UPDATE aadA8 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 4815 UPDATE OXA-114p penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2041 UPDATE OXA-424 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1843 UPDATE rmtD gentamicin; 16S rRNA methyltransferase (G1405); arbekacin; antibiotic target alteration; amikacin; aminoglycoside antibiotic; gentamicin A; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 4819 UPDATE OXA-114t penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4818 UPDATE OXA-114s penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2048 UPDATE OXA-57 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1844 UPDATE OXA-128 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4832 UPDATE OXA-494 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1536 UPDATE OXA-421 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4958 UPDATE OXA-632 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 642 UPDATE aadA25 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 1532 UPDATE OXA-249 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1530 UPDATE OXA-67 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4952 UPDATE OXA-626 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4953 UPDATE OXA-627 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4950 UPDATE OXA-624 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4951 UPDATE OXA-625 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4956 UPDATE OXA-630 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4957 UPDATE OXA-631 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 430 UPDATE OXA-87 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4955 UPDATE OXA-629 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2143 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin antibiotic target alteration; aminoglycoside antibiotic; gentamicin C; gentamicin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1596 UPDATE OXA-24 penam; antibiotic inactivation; carbapenem; BAL30072; cephalosporin; cefalotin; oxacillin; monobactam; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 339 UPDATE ANT(3'')-Ii-AAC(6')-IId fusion protein 2'-N-ethylnetilmicin; 5-episisomicin; aminoglycoside antibiotic; gentamicin; sisomicin; antibiotic inactivation; spectinomycin; netilmicin; aminoglycoside bifunctional resistance protein; streptomycin; dibekacin; gentamicin A; tobramycin; ARO_description; CARD_short_name; ARO_category; model_name; ARO_name "UPDATED ARO_description with ANT(3'')-II-AAC(6')-IId is an integron-encoded aminoglycoside acetyltransferase in S. marcescens. UPDATED CARD_short_name with ANT3II_ANT6II DELETED 36484 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with aminoglycoside bifunctional resistance protein UPDATED category_aro_cvterm_id with 46171 UPDATED category_aro_accession with 3007419 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Bifunctional aminoglycoside-inactivating enzymes composed of two separate functional domains. These proteins possess activity from both enzyme components, thereby conferring resistance to the combination of antibiotics from both domains, and may include acetylation, phosphorylation or nucleotidylation activity. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED model_name with ANT(3'')-II-AAC(6')-IId bifunctional protein UPDATED ARO_name with ANT(3'')-II-AAC(6')-IId bifunctional protein " 3805 UPDATE ParS erythromycin; penem; tetracycline antibiotic; meropenem; antibiotic efflux; imipenem; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; reduced permeability to antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; penam; gentamicin; Outer Membrane Porin (Opr); efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 334 UPDATE mexX erythromycin; arbekacin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; penam; gentamicin; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1093 UPDATE AAC(6')-31 antibiotic inactivation; kanamycin A; AAC(6'); aminoglycoside antibiotic; gentamicin; sisomicin; netilmicin; amikacin; isepamicin; neomycin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 40942 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 3806 UPDATE ParR erythromycin; penem; tetracycline antibiotic; meropenem; antibiotic efflux; imipenem; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; reduced permeability to antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; penam; gentamicin; Outer Membrane Porin (Opr); efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 3801 UPDATE AAC(3)-IVb antibiotic inactivation; AAC(3); gentamicin; aminoglycoside antibiotic; gentamicin A; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 3800 UPDATE OXA-837 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; ampicillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3802 UPDATE ANT(3'')-Ib antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 1372 UPDATE ANT(2'')-Ia antibiotic inactivation; kanamycin A; aminoglycoside antibiotic; gentamicin; sisomicin; ANT(2''); dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 2''-hydroxyl group of the compound. DELETED 35933 UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 3298 UPDATE Klebsiella pneumoniae KpnG penem; piperacillin; antibiotic efflux; imipenem; major facilitator superfamily (MFS) antibiotic efflux pump; norfloxacin; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; spectinomycin; ciprofloxacin; gentamicin C; streptomycin; aminoglycoside antibiotic; polymyxin B1; polymyxin B; peptide antibiotic; ticarcillin; ertapenem; penam; gentamicin; efflux pump complex or subunit conferring antibiotic resistance; polymyxin B2; polymyxin B3; polymyxin B4; fluoroquinolone antibiotic; erythromycin; azithromycin; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 4907 UPDATE OXA-581 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5139 UPDATE OXA-840 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5138 UPDATE OXA-839 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3294 UPDATE erm(32) methymycin; narbomycin; Erm 23S ribosomal RNA methyltransferase; pikromycin; macrolide antibiotic; antibiotic target alteration; streptogramin antibiotic; lincosamide antibiotic; ARO_category "UPDATED category_aro_name with methymycin UPDATED category_aro_cvterm_id with 37631 UPDATED category_aro_accession with 3001232 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Produced by Streptomyces venezuelae ATCC 15439. UPDATED category_aro_name with narbomycin UPDATED category_aro_cvterm_id with 37625 UPDATED category_aro_accession with 3001226 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Produced by Streptomyces narbonensis. UPDATED category_aro_name with pikromycin UPDATED category_aro_cvterm_id with 37632 UPDATED category_aro_accession with 3001233 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Produced by Streptomyces venezuelae ATCC 15439. " 5136 UPDATE OXA-834 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5135 UPDATE OXA-833 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5134 UPDATE OXA-832 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1902 UPDATE OXA-246 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5132 UPDATE OXA-830 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5131 UPDATE OXA-829 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5130 UPDATE OXA-828 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3452 UPDATE OXA-288 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3453 UPDATE OXA-289 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3450 UPDATE OXA-285 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3518 UPDATE OXA-449 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 850 UPDATE OXA-26 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3457 UPDATE OXA-294 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3454 UPDATE OXA-291 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3455 UPDATE OXA-292 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3513 UPDATE OXA-443 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3512 UPDATE OXA-442 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3511 UPDATE OXA-441 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3510 UPDATE OXA-440 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3517 UPDATE OXA-448 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3516 UPDATE OXA-447 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3515 UPDATE OXA-446 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3514 UPDATE OXA-444 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1186 UPDATE OXA-327 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4854 UPDATE OXA-519 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2688 UPDATE ArmR sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 2685 UPDATE Pseudomonas aeruginosa CpxR sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; aminoglycoside antibiotic; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; penam; ceftriaxone; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 2686 UPDATE MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 5123 UPDATE OXA-820 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2680 UPDATE MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 2682 UPDATE MexAB-OprM with NalC mutations conferring resistance to aztreonam sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 2683 UPDATE MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; penam; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; nalidixic acid; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 3508 UPDATE OXA-438 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5173 UPDATE OXA-876 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3509 UPDATE OXA-439 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5089 UPDATE OXA-781 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1187 UPDATE OXA-248 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5088 UPDATE OXA-780 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 96 UPDATE OXA-426 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5182 UPDATE OXA-885 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5183 UPDATE OXA-886 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5229 UPDATE OXA-945 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5228 UPDATE OXA-943 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5186 UPDATE OXA-889 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5187 UPDATE OXA-890 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1625 UPDATE OXA-179 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5185 UPDATE OXA-888 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5223 UPDATE OXA-938 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4074 UPDATE OXA-653 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5188 UPDATE OXA-891 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4076 UPDATE OXA-825 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5227 UPDATE OXA-942 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5226 UPDATE OXA-941 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4073 UPDATE OXA-897 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5224 UPDATE OXA-939 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3500 UPDATE OXA-417 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3501 UPDATE OXA-427 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 461 UPDATE OXA-13 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5811 UPDATE KPC-123 penam; carbapenem; cephalosporin; cefotaxime; ceftazidime; cefepime; antibiotic inactivation; monobactam; KPC beta-lactamase; ARO_category "DELETED 45634 " 1293 UPDATE OXA-197 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3502 UPDATE OXA-429 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5817 UPDATE AAC(6')-Iap 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. " 1317 UPDATE CTX-M-3 penam; antibiotic inactivation; cephalosporin; cefazolin; ceftazidime; cefalotin; cephamycin; ampicillin; cefixime; ceftriaxone; cefoxitin; CTX-M beta-lactamase; ARO_category "DELETED 35981 " 742 UPDATE AAC(3)-Id antibiotic inactivation; AAC(3); gentamicin; sisomicin; astromicin; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. DELETED 35933 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 5080 UPDATE OXA-771 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 746 UPDATE AAC(2')-Ib antibiotic inactivation; aminoglycoside antibiotic; gentamicin; AAC(2'); 6'-N-ethylnetilmicin; netilmicin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound. DELETED 35932 UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with 6'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46127 UPDATED category_aro_accession with 3007377 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. " 4889 UPDATE OXA-560 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 555 UPDATE OXA-133 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 554 UPDATE OXA-163 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1185 UPDATE OXA-176 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3633 UPDATE OXA-724 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5086 UPDATE OXA-777 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5054 UPDATE OXA-745 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1314 UPDATE OXA-214 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 239 UPDATE OXA-83 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5026 UPDATE OXA-714 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5055 UPDATE OXA-746 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 235 UPDATE OXA-181 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "DELETED 40951 UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3507 UPDATE OXA-437 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 230 UPDATE OXA-422 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 231 UPDATE OXA-178 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5060 UPDATE OXA-751 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1050 UPDATE AAC(6')-Ii 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 40307 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1052 UPDATE OXA-206 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 909 UPDATE OXA-5 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 993 UPDATE AAC(6')-Ib9 antibiotic inactivation; AAC(6'); kanamycin A; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with kanamycin A UPDATED category_aro_cvterm_id with 35966 UPDATED category_aro_accession with 0000049 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 2227 UPDATE VCC-1 penam; antibiotic inactivation; imipenem; aztreonam; VCC beta-lactamase; carbapenem; monobactam; ertapenem; doripenem; meropenem; ARO_category "UPDATED category_aro_name with imipenem UPDATED category_aro_cvterm_id with 36309 UPDATED category_aro_accession with 3000170 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes. UPDATED category_aro_name with meropenem UPDATED category_aro_cvterm_id with 35990 UPDATED category_aro_accession with 0000073 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. UPDATED category_aro_name with doripenem UPDATED category_aro_cvterm_id with 36984 UPDATED category_aro_accession with 3000640 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Doripenem is a carbapenem with a broad range of activity against Gram-positive and Gram-negative bacteria, and along with meropenem, it is the most active beta-lactam antibiotic against Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis. UPDATED category_aro_name with ertapenem UPDATED category_aro_cvterm_id with 35987 UPDATED category_aro_accession with 0000070 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis. UPDATED category_aro_name with aztreonam UPDATED category_aro_cvterm_id with 36689 UPDATED category_aro_accession with 3000550 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death. " 3340 UPDATE aacA43 AAC(6'); kanamycin A; antibiotic inactivation; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 5062 UPDATE OXA-753 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2223 UPDATE MexZ erythromycin; arbekacin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; penam; gentamicin; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1196 UPDATE OXA-71 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5146 UPDATE OXA-848 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1694 UPDATE OXA-353 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 784 UPDATE AAC(6')-Iv 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 1690 UPDATE OXA-317 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1758 UPDATE OXA-326 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5144 UPDATE OXA-845 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1750 UPDATE OXA-254 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 146 UPDATE OXA-98 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1176 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid isoniazid; isoniazid resistant katG; antibiotic target alteration; isoniazid-like antibiotic; ARO_category; model_param "UPDATED category_aro_name with isoniazid UPDATED category_aro_cvterm_id with 36659 UPDATED category_aro_accession with 3000520 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. DELETED 3758 UPDATED 12838 with N596S,Y597H " 145 UPDATE OXA-229 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1172 UPDATE OXA-194 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 140 UPDATE AAC(6')-IIb 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; gentamicin; sisomicin; antibiotic inactivation; netilmicin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1271 UPDATE AAC(6')-Iw 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 611 UPDATE OXA-328 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 617 UPDATE OXA-147 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1276 UPDATE OXA-210 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 149 UPDATE aadA12 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 5140 UPDATE OXA-841 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5141 UPDATE OXA-842 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1610 UPDATE OXA-74 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1882 UPDATE OXA-80 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1881 UPDATE OXA-72 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1212 UPDATE OXA-141 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5085 UPDATE OXA-776 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1281 UPDATE OXA-110 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3438 UPDATE OXA-271 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4918 UPDATE OXA-592 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4919 UPDATE OXA-593 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4916 UPDATE OXA-590 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4917 UPDATE OXA-591 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4914 UPDATE OXA-588 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4915 UPDATE OXA-589 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4912 UPDATE OXA-586 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1288 UPDATE OXA-82 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4910 UPDATE OXA-584 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4911 UPDATE OXA-585 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1967 UPDATE OXA-116 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2060 UPDATE FosC2 fosfomycin; phosphonic acid antibiotic; antibiotic inactivation; fosC phosphotransferase family; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 1474 UPDATE MexR sulfonamide antibiotic; penem; panipenem; antibiotic target alteration; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; colistin B; protein(s) and two-component regulatory system modulating antibiotic efflux; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ampicillin; penam; sulfamethoxazole; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 1190 UPDATE OXA-354 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 685 UPDATE OXA-239 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1572 UPDATE OXA-205 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 687 UPDATE APH(3')-Vc antibiotic inactivation; aminoglycoside antibiotic; paromomycin; APH(3'); ribostamycin; neomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 " 686 UPDATE OXA-162 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1577 UPDATE AAC(6')-32 antibiotic inactivation; AAC(6'); gentamicin; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 40942 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1576 UPDATE OXA-17 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1575 UPDATE OXA-91 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1574 UPDATE Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid isoniazid; antibiotic target alteration; isoniazid-like antibiotic; isoniazid resistant inhA; ARO_category "UPDATED category_aro_name with isoniazid UPDATED category_aro_cvterm_id with 36659 UPDATED category_aro_accession with 3000520 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. " 2712 UPDATE MexXY-OprA antibiotic efflux; tobramycin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; ofloxacin; norfloxacin; meropenem; macrolide antibiotic; carbapenem; gentamicin; arbekacin; ciprofloxacin; tetracycline antibiotic; gentamicin C; amikacin; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1305 UPDATE OprM sulfonamide antibiotic; tetracycline; erythromycin; penem; panipenem; thiamphenicol; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; ofloxacin; norfloxacin; nalidixic acid; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; gentamicin C; amikacin; ceftriaxone; disinfecting agents and antiseptics; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; penam; aminoglycoside antibiotic; sulfamethoxazole; gentamicin; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; acriflavine; monobactam; fluoroquinolone antibiotic; chloramphenicol; trimethoprim; azithromycin; tobramycin; ARO_category "DELETED 35996 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 5171 UPDATE OXA-874 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5170 UPDATE OXA-873 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5177 UPDATE OXA-880 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5176 UPDATE OXA-879 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5175 UPDATE OXA-878 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5174 UPDATE OXA-877 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5179 UPDATE OXA-882 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5178 UPDATE OXA-881 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2655 UPDATE Pseudomonas aeruginosa emrE antibiotic efflux; small multidrug resistance (SMR) antibiotic efflux pump; gentamicin; efflux pump complex or subunit conferring antibiotic resistance; gentamicin C; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1194 UPDATE OXA-16 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3416 UPDATE OXA-152 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3417 UPDATE OXA-153 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5078 UPDATE OXA-769 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5079 UPDATE OXA-770 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5744 UPDATE msr(I) macrolide antibiotic; phosphonic acid antibiotic; msr-type ABC-F protein; antibiotic target protection; fosfomycin; streptogramin antibiotic; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. UPDATED category_aro_name with phosphonic acid antibiotic UPDATED category_aro_cvterm_id with 45731 UPDATED category_aro_accession with 3007149 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with A group of antibiotics derived from phosphonic acids. " 3413 UPDATE OXA-127 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3410 UPDATE OXA-124 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3411 UPDATE OXA-125 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5072 UPDATE OXA-763 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5073 UPDATE OXA-764 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5070 UPDATE OXA-761 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5071 UPDATE OXA-762 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5076 UPDATE OXA-767 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5077 UPDATE OXA-768 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3418 UPDATE OXA-154 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5075 UPDATE OXA-766 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1833 UPDATE OXA-374 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1830 UPDATE APH(3'')-Ib antibiotic inactivation; APH(3''); streptomycin; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 3''-hydroxyl group of the compound. " 1831 UPDATE AAC(6')-Iid 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1836 UPDATE OXA-201 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 21 UPDATE OXA-329 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 23 UPDATE OXA-371 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 914 UPDATE ANT(6)-Ia antibiotic inactivation; streptomycin; aminoglycoside antibiotic; ANT(6); ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 6-hydroxyl group of the compound. " 1839 UPDATE aadA14 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 28 UPDATE OXA-45 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3412 UPDATE OXA-126 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 137 UPDATE APH(2'')-Ie antibiotic inactivation; gentamicin; kanamycin A; APH(2''); amikacin; aminoglycoside antibiotic; gentamicin A; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 35953 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 407 UPDATE OXA-352 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4980 UPDATE OXA-660 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 405 UPDATE OXA-202 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4869 UPDATE OXA-534 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4985 UPDATE OXA-669 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4984 UPDATE OXA-667 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4987 UPDATE OXA-674 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4986 UPDATE OXA-670 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1379 UPDATE OXA-313 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1378 UPDATE AAC(3)-IIc 2'-N-ethylnetilmicin; antibiotic inactivation; AAC(3); aminoglycoside antibiotic; gentamicin; 6'-N-ethylnetilmicin; sisomicin; netilmicin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with 6'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46127 UPDATED category_aro_accession with 3007377 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 931 UPDATE OXA-316 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2016 UPDATE OXA-370 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 937 UPDATE OXA-242 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4867 UPDATE OXA-532 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 935 UPDATE OXA-314 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 408 UPDATE OXA-380 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3834 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide thioamide antibiotic; antibiotic target alteration; prothionamide resistant katG; prothionamide; ARO_category "UPDATED category_aro_name with prothionamide UPDATED category_aro_cvterm_id with 40958 UPDATED category_aro_accession with 3004025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Prothionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections. " 3836 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid isoniazid; isoniazid-like antibiotic; antibiotic target alteration; isoniazid resistant ethA; ARO_category "UPDATED category_aro_name with isoniazid UPDATED category_aro_cvterm_id with 36659 UPDATED category_aro_accession with 3000520 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. " 3837 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide thioamide antibiotic; antibiotic target alteration; prothionamide; prothionamide resistant ethA; ARO_category "UPDATED category_aro_name with prothionamide UPDATED category_aro_cvterm_id with 40958 UPDATED category_aro_accession with 3004025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Prothionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections. " 3832 UPDATE FosB2 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; phosphonic acid antibiotic; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 2179 UPDATE glycopeptide resistance gene cluster VanE glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vancomycin; model_description "UPDATED model_description with Gene Cluster Meta-Models (GCM) are used to curate spatial clusters of individual genes within operons, such as for glycopeptide resistance gene clusters. The individual genes will have their own individual detection models (e.g. PHM, PVM, POM, etc.) while the GCM checks to see if all the component genes of the cluster have a Strict or Perfect hit and are ordered correctly within an operon. GCMs are encoded using the gene order parameter. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software. " 3838 UPDATE Mycobacterium tuberculosis mshA mutations conferring resistance to prothionamide thioamide antibiotic; antibiotic target alteration; prothionamide; prothionamide resistant mshA; ARO_category "UPDATED category_aro_name with prothionamide UPDATED category_aro_cvterm_id with 40958 UPDATED category_aro_accession with 3004025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Prothionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections. " 1955 UPDATE OXA-29 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1937 UPDATE OXA-118 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1952 UPDATE OXA-1 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; amoxicillin; ampicillin; cloxacillin; piperacillin; OXA beta-lactamase; ARO_category "DELETED 35996 UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 457 UPDATE OXA-93 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 916 UPDATE OXA-36 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4893 UPDATE OXA-564 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 379 UPDATE OXA-148 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3840 UPDATE AAC(6')-Ib-cr3 antibiotic inactivation; AAC(6')-Ib-cr; AAC(6'); kanamycin A; ciprofloxacin; fluoroquinolone antibiotic; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_name with AAC(6') UPDATED category_aro_cvterm_id with 36484 UPDATED category_aro_accession with 3000345 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 5690 UPDATE VHW-1 antibiotic inactivation; penam; carbapenem; cephalosporin; VHW beta-lactamase; ampicillin; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. " 3842 UPDATE AAC(6')-Ib-cr5 antibiotic inactivation; AAC(6')-Ib-cr; AAC(6'); kanamycin A; ciprofloxacin; fluoroquinolone antibiotic; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_name with AAC(6') UPDATED category_aro_cvterm_id with 36484 UPDATED category_aro_accession with 3000345 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 3845 UPDATE AAC(6')-Ib-cr8 antibiotic inactivation; AAC(6')-Ib-cr; AAC(6'); kanamycin A; ciprofloxacin; fluoroquinolone antibiotic; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_name with AAC(6') UPDATED category_aro_cvterm_id with 36484 UPDATED category_aro_accession with 3000345 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 3844 UPDATE AAC(6')-Ib-cr7 antibiotic inactivation; AAC(6')-Ib-cr; AAC(6'); kanamycin A; ciprofloxacin; fluoroquinolone antibiotic; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_name with AAC(6') UPDATED category_aro_cvterm_id with 36484 UPDATED category_aro_accession with 3000345 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 3846 UPDATE AAC(6')-Ib-cr9 antibiotic inactivation; AAC(6')-Ib-cr; AAC(6'); kanamycin A; ciprofloxacin; fluoroquinolone antibiotic; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_name with AAC(6') UPDATED category_aro_cvterm_id with 36484 UPDATED category_aro_accession with 3000345 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 826 UPDATE TolC tetracycline; erythromycin; penem; tetracycline antibiotic; piperacillin; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; nalidixic acid; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; cefalotin; spectinomycin; glycylcycline; oxacillin; ciprofloxacin; cloxacillin; gentamicin C; streptomycin; aminoglycoside antibiotic; disinfecting agents and antiseptics; polymyxin B3; polymyxin B1; polymyxin B; rifamycin antibiotic; imipenem; peptide antibiotic; rifampin; ticarcillin; ampicillin; ertapenem; penam; triclosan; gentamicin; novobiocin; efflux pump complex or subunit conferring antibiotic resistance; polymyxin B2; tigecycline; polymyxin B4; cephamycin; fluoroquinolone antibiotic; tobramycin; phenicol antibiotic; azithromycin; chloramphenicol; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 4062 UPDATE OXA-931 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 605 UPDATE OXA-96 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 147 UPDATE OXA-27 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 704 UPDATE OprJ penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; aminocoumarin antibiotic; trimethoprim; gentamicin; novobiocin; macrolide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; gentamicin C; chloramphenicol; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 4879 UPDATE OXA-550 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 706 UPDATE APH(7'')-Ia antibiotic inactivation; APH(7''); hygromycin B; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 7''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 7''-hydroxyl group of the compound. " 1483 UPDATE AAC(3)-Xa kanamycin A; antibiotic inactivation; AAC(3); aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. " 392 UPDATE TUS-1 penam; antibiotic inactivation; TUS beta-lactamase; penem; carbapenem; cephalosporin; cephamycin; ticarcillin; amoxicillin; piperacillin; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with amoxicillin UPDATED category_aro_cvterm_id with 35981 UPDATED category_aro_accession with 0000064 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. UPDATED category_aro_name with piperacillin UPDATED category_aro_cvterm_id with 35995 UPDATED category_aro_accession with 0000078 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria. UPDATED category_aro_name with penem UPDATED category_aro_cvterm_id with 40360 UPDATED category_aro_accession with 3003706 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur. UPDATED category_aro_name with ticarcillin UPDATED category_aro_cvterm_id with 40523 UPDATED category_aro_accession with 3003832 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death. " 391 UPDATE VIM-2 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; cephamycin; VIM beta-lactamase; ARO_category "DELETED 36727 " 397 UPDATE OXA-357 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 394 UPDATE OXA-130 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 795 UPDATE OXA-324 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4047 UPDATE OXA-779 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1717 UPDATE OXA-230 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1716 UPDATE OXA-398 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1715 UPDATE OXA-73 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4048 UPDATE OXA-838 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4049 UPDATE OXA-539 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1659 UPDATE OXA-258 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1653 UPDATE AAC(6')-Ip 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1651 UPDATE AAC(6')-If 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 1657 UPDATE AAC(6')-IIa 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; gentamicin; sisomicin; antibiotic inactivation; netilmicin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 410 UPDATE AAC(3)-IIIb antibiotic inactivation; kanamycin A; AAC(3); 5-episisomicin; aminoglycoside antibiotic; gentamicin; lividomycin; paromomycin; sisomicin; dibekacin; neomycin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with lividomycin UPDATED category_aro_cvterm_id with 37002 UPDATED category_aro_accession with 3000658 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. UPDATED category_aro_name with paromomycin UPDATED category_aro_cvterm_id with 37001 UPDATED category_aro_accession with 3000657 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with neomycin UPDATED category_aro_cvterm_id with 35924 UPDATED category_aro_accession with 0000005 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 584 UPDATE aadA21 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 4944 UPDATE OXA-618 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1132 UPDATE OXA-88 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1131 UPDATE AAC(3)-Ic antibiotic inactivation; AAC(3); gentamicin; sisomicin; astromicin; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. DELETED 35933 UPDATED category_aro_name with astromicin UPDATED category_aro_cvterm_id with 35922 UPDATED category_aro_accession with 0000003 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Astromicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Astromicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 2284 UPDATE Escherichia coli murA with mutation conferring resistance to fosfomycin fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; antibiotic-resistant murA transferase; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 2285 UPDATE Staphylococcus aureus murA with mutation conferring resistance to fosfomycin fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; antibiotic-resistant murA transferase; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 2286 UPDATE Borreliella burgdorferi murA with mutation conferring resistance to fosfomycin fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; antibiotic-resistant murA transferase; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 1384 UPDATE OXA-382 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4946 UPDATE OXA-620 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4071 UPDATE OXA-646 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 243 UPDATE OXA-9 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2837 UPDATE APH(2'')-If antibiotic inactivation; kanamycin A; aminoglycoside antibiotic; gentamicin; sisomicin; APH(2''); dibekacin; gentamicin A; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36998 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 4941 UPDATE OXA-615 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 615 UPDATE OXA-211 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 675 UPDATE OXA-25 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2832 UPDATE AAC(2')-Ie antibiotic inactivation; aminoglycoside antibiotic; gentamicin; AAC(2'); 6'-N-ethylnetilmicin; netilmicin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound. DELETED 35932 UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with 6'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46127 UPDATED category_aro_accession with 3007377 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. " 2276 UPDATE Staphylococcus aureus ileS with mutation conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); antibiotic target alteration; mupirocin-like antibiotic; mupirocin; ARO_category "UPDATED category_aro_name with mupirocin UPDATED category_aro_cvterm_id with 36693 UPDATED category_aro_accession with 3000554 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Mupirocin, also known as pseudomonic acid, is a bacteriostatic polyketide antibiotic from Pseudomonas fluorescens used to treat S. aureus and MRSA. It inhibits Ile tRNA synthetase. " 4943 UPDATE OXA-617 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3399 UPDATE aadA8b antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 3398 UPDATE aadA10 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 4942 UPDATE OXA-616 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 925 UPDATE AAC(3)-IIb 2'-N-ethylnetilmicin; antibiotic inactivation; AAC(3); aminoglycoside antibiotic; gentamicin; 6'-N-ethylnetilmicin; sisomicin; netilmicin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. DELETED 35932 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with 6'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46127 UPDATED category_aro_accession with 3007377 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 4972 UPDATE OXA-651 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5231 UPDATE OXA-947 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 927 UPDATE OXA-381 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1003 UPDATE OXA-18 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1002 UPDATE AAC(6')-Ib4 antibiotic inactivation; AAC(6'); kanamycin A; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 40942 UPDATED category_aro_name with kanamycin A UPDATED category_aro_cvterm_id with 35966 UPDATED category_aro_accession with 0000049 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1000 UPDATE AAC(6')-Ib-Hangzhou antibiotic inactivation; AAC(6'); kanamycin A; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with kanamycin A UPDATED category_aro_cvterm_id with 35966 UPDATED category_aro_accession with 0000049 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1227 UPDATE aadA2 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 1087 UPDATE OXA-253 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 620 UPDATE OXA-320 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5038 UPDATE OXA-728 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5039 UPDATE OXA-729 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5036 UPDATE OXA-726 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5037 UPDATE OXA-727 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5034 UPDATE OXA-722 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1343 UPDATE OXA-166 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5032 UPDATE OXA-720 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5033 UPDATE OXA-721 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5030 UPDATE OXA-718 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5031 UPDATE OXA-719 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1862 UPDATE OXA-109 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1874 UPDATE OXA-196 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1870 UPDATE OXA-66 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1871 UPDATE OXA-389 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 978 UPDATE OXA-134 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4895 UPDATE OXA-566 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1879 UPDATE AAC(3)-IIIa antibiotic inactivation; kanamycin A; AAC(3); 5-episisomicin; aminoglycoside antibiotic; gentamicin; lividomycin; paromomycin; sisomicin; dibekacin; neomycin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. DELETED 35933 UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with lividomycin UPDATED category_aro_cvterm_id with 37002 UPDATED category_aro_accession with 3000658 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. UPDATED category_aro_name with paromomycin UPDATED category_aro_cvterm_id with 37001 UPDATED category_aro_accession with 3000657 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes. UPDATED category_aro_name with kanamycin A UPDATED category_aro_cvterm_id with 35966 UPDATED category_aro_accession with 0000049 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with neomycin UPDATED category_aro_cvterm_id with 35924 UPDATED category_aro_accession with 0000005 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 977 UPDATE OXA-112 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2050 UPDATE OXA-331 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4947 UPDATE OXA-621 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2052 UPDATE APH(3'')-Ic antibiotic inactivation; APH(3''); streptomycin; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 3''-hydroxyl group of the compound. " 973 UPDATE OXA-378 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4940 UPDATE OXA-614 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4828 UPDATE OXA-396 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4829 UPDATE OXA-489 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4826 UPDATE OXA-307 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4827 UPDATE OXA-395 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4824 UPDATE OXA-159 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4825 UPDATE OXA-193 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4822 UPDATE OXA-114w penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4823 UPDATE OXA-114x penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4820 UPDATE OXA-114u penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4821 UPDATE OXA-114v penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1502 UPDATE OXA-209 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1500 UPDATE APH(6)-Ia antibiotic inactivation; APH(6); streptomycin; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 6-hydroxyl group of the compound. DELETED 40307 " 655 UPDATE OXA-243 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 186 UPDATE OXA-12 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 187 UPDATE OXA-348 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 650 UPDATE aadA antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 185 UPDATE OXA-232 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 853 UPDATE OXA-160 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2114 UPDATE APH(3')-IIa antibiotic inactivation; aminoglycoside antibiotic; gentamicin; paromomycin; kanamycin A; APH(3'); gentamicin B; ribostamycin; neomycin; butirosin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 UPDATED category_aro_name with kanamycin A UPDATED category_aro_cvterm_id with 35966 UPDATED category_aro_accession with 0000049 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1122 UPDATE OXA-180 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 659 UPDATE AAC(6')-29b antibiotic inactivation; aminoglycoside antibiotic; AAC(6'); dibekacin; kanamycin A; amikacin; isepamicin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 3879 UPDATE APH(3')-XV kanamycin A; APH(3'); amikacin; aminoglycoside antibiotic; antibiotic inactivation; ARO_description; CARD_short_name; ARO_category; model_name; ARO_name "UPDATED ARO_description with APH(3')-XVa is an aminoglycoside O-phosphotransferase found in Pseudomonas aeruginosa. UPDATED CARD_short_name with APH(3')-XVa UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 UPDATED model_name with APH(3')-XVa UPDATED ARO_name with APH(3')-XVa " 3545 UPDATE OXA-484 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 676 UPDATE AAC(6')-Ih 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 5019 UPDATE OXA-707 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3526 UPDATE OXA-459 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1918 UPDATE spd antibiotic inactivation; aminoglycoside antibiotic; spectinomycin; ANT(9); ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 9-hydroxyl group of the compound. " 3524 UPDATE OXA-457 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5109 UPDATE OXA-804 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3522 UPDATE OXA-453 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3523 UPDATE OXA-455 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3520 UPDATE OXA-451 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3521 UPDATE OXA-452 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5102 UPDATE OXA-797 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5103 UPDATE OXA-798 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5100 UPDATE OXA-795 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5101 UPDATE OXA-796 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5106 UPDATE OXA-801 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5107 UPDATE OXA-802 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3528 UPDATE OXA-461 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3529 UPDATE OXA-464 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3885 UPDATE OXA-812 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3884 UPDATE OXA-818 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3886 UPDATE FosA7.5 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; phosphonic acid antibiotic; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 3449 UPDATE OXA-284 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3448 UPDATE OXA-283 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3883 UPDATE OXA-668 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 861 UPDATE OXA-215 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 18 UPDATE OXA-212 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3447 UPDATE OXA-282 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3446 UPDATE OXA-281 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 865 UPDATE OXA-244 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3440 UPDATE OXA-273 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3443 UPDATE OXA-277 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3442 UPDATE OXA-276 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2026 UPDATE OXA-84 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2755 UPDATE ANT(3'')-IIc antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 2752 UPDATE ANT(3'')-IIa antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 2750 UPDATE APH(3')-VIIIb kanamycin A; APH(3'); amikacin; aminoglycoside antibiotic; antibiotic inactivation; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 " 2128 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to gentamicin antibiotic target alteration; aminoglycoside antibiotic; gentamicin C; gentamicin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 2695 UPDATE MexCD-OprJ with type B NfxB mutation penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; aminocoumarin antibiotic; trimethoprim; gentamicin; novobiocin; macrolide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; gentamicin C; chloramphenicol; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 2117 UPDATE AAC(6')-Ib7 antibiotic inactivation; AAC(6'); kanamycin A; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with kanamycin A UPDATED category_aro_cvterm_id with 35966 UPDATED category_aro_accession with 0000049 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 2693 UPDATE Type B NfxB penam; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; protein(s) and two-component regulatory system modulating antibiotic efflux; ofloxacin; aminocoumarin antibiotic; trimethoprim; gentamicin; novobiocin; macrolide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; diaminopyrimidine antibiotic; tetracycline antibiotic; gentamicin C; chloramphenicol; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 656 UPDATE OXA-219 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 880 UPDATE APH(6)-Ib antibiotic inactivation; APH(6); streptomycin; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 6-hydroxyl group of the compound. " 4863 UPDATE OXA-528 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 942 UPDATE OXA-104 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2256 UPDATE Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid antibiotic resistant fusE; antibiotic target alteration; fusidic acid; fusidane antibiotic; ARO_category "UPDATED category_aro_name with fusidic acid UPDATED category_aro_cvterm_id with 37139 UPDATED category_aro_accession with 3000759 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to block protein synthesis. " 2087 UPDATE aadA13 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 5216 UPDATE OXA-925 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5217 UPDATE OXA-927 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5214 UPDATE OXA-923 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5215 UPDATE OXA-924 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5212 UPDATE OXA-921 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5213 UPDATE OXA-922 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5210 UPDATE OXA-919 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5211 UPDATE OXA-920 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5011 UPDATE OXA-699 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5218 UPDATE OXA-928 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5219 UPDATE OXA-929 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5199 UPDATE OXA-907 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5198 UPDATE OXA-905 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1618 UPDATE OXA-362 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 30 UPDATE OXA-226 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5195 UPDATE OXA-902 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5194 UPDATE OXA-901 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5197 UPDATE OXA-904 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1615 UPDATE APH(2'')-IIa antibiotic inactivation; APH(2''); aminoglycoside antibiotic; plazomicin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 35953 " 5191 UPDATE OXA-894 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5190 UPDATE OXA-893 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1962 UPDATE OXA-47 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5192 UPDATE OXA-896 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 323 UPDATE aadA9 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 5809 UPDATE glycopeptide resistance gene cluster vanP glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vancomycin; teicoplanin; model_description "UPDATED model_description with Gene Cluster Meta-Models (GCM) are used to curate spatial clusters of individual genes within operons, such as for glycopeptide resistance gene clusters. The individual genes will have their own individual detection models (e.g. PHM, PVM, POM, etc.) while the GCM checks to see if all the component genes of the cluster have a Strict or Perfect hit and are ordered correctly within an operon. GCMs are encoded using the gene order parameter. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software. " 326 UPDATE OXA-225 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 352 UPDATE PDC-5 penam; carbapenem; cephalosporin; cefazolin; ampicillin; ceftazidime; cefalotin; cephamycin; antibiotic inactivation; PDC beta-lactamase; monobactam; cefixime; ceftriaxone; cefoxitin; ARO_category "DELETED 35981 " 5098 UPDATE OXA-793 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2877 UPDATE OXA-535 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2876 UPDATE OXA-436 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5099 UPDATE OXA-794 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 209 UPDATE AAC(3)-Ib/AAC(6')-Ib'' fusion protein antibiotic inactivation; kanamycin A; gentamicin; sisomicin; astromicin; aminoglycoside bifunctional resistance protein; amikacin; aminoglycoside antibiotic; tobramycin; ARO_description; ARO_category; ARO_name "UPDATED ARO_description with AAC(3)-Ib/AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. DELETED 36484 UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with astromicin UPDATED category_aro_cvterm_id with 35922 UPDATED category_aro_accession with 0000003 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Astromicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Astromicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with aminoglycoside bifunctional resistance protein UPDATED category_aro_cvterm_id with 46171 UPDATED category_aro_accession with 3007419 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Bifunctional aminoglycoside-inactivating enzymes composed of two separate functional domains. These proteins possess activity from both enzyme components, thereby conferring resistance to the combination of antibiotics from both domains, and may include acetylation, phosphorylation or nucleotidylation activity. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED ARO_name with AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein " 4069 UPDATE OXA-647 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2878 UPDATE almG colistin B; colistin A; polymyxin resistance operon; peptide antibiotic; antibiotic target alteration; lipid A acyltransferase; ARO_category "DELETED 36593 UPDATED category_aro_name with colistin B UPDATED category_aro_cvterm_id with 36968 UPDATED category_aro_accession with 3000624 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. UPDATED category_aro_name with colistin A UPDATED category_aro_cvterm_id with 36966 UPDATED category_aro_accession with 3000622 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. UPDATED category_aro_name with polymyxin resistance operon UPDATED category_aro_cvterm_id with 46184 UPDATED category_aro_accession with 3007428 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Operon or gene clusters confering resistance to polymyxin antibiotics. " 779 UPDATE OXA-350 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1398 UPDATE OXA-108 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3356 UPDATE OXA-296 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 73 UPDATE OXA-35 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5065 UPDATE OXA-756 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4892 UPDATE OXA-563 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4835 UPDATE OXA-500 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4866 UPDATE OXA-531 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1570 UPDATE OprA antibiotic efflux; tobramycin; resistance-nodulation-cell division (RND) antibiotic efflux pump; efflux pump complex or subunit conferring antibiotic resistance; ofloxacin; norfloxacin; meropenem; macrolide antibiotic; carbapenem; gentamicin; arbekacin; ciprofloxacin; tetracycline antibiotic; gentamicin C; amikacin; aminoglycoside antibiotic; fluoroquinolone antibiotic; tetracycline; erythromycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 834 UPDATE FosA3 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; phosphonic acid antibiotic; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 3527 UPDATE OXA-460 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 835 UPDATE APH(3')-Ib antibiotic inactivation; aminoglycoside antibiotic; gentamicin; lividomycin; paromomycin; kanamycin A; APH(3'); gentamicin B; ribostamycin; neomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with lividomycin UPDATED category_aro_cvterm_id with 37002 UPDATED category_aro_accession with 3000658 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. " 1341 UPDATE OXA-53 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5108 UPDATE OXA-803 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1681 UPDATE APH(4)-Ib antibiotic inactivation; hygromycin B; aminoglycoside antibiotic; APH(4); ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 4-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 4-hydroxyl group of the compound. " 1682 UPDATE aadA24 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 3423 UPDATE OXA-185 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1686 UPDATE OXA-34 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1762 UPDATE aadA16 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 2201 UPDATE PvrR penam; gentamicin; kanamycin A; phenotypic variant regulator; gentamicin A; carbenicillin; tetracycline antibiotic; resistance by absence; amikacin; aminoglycoside antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 1761 UPDATE OXA-351 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5167 UPDATE OXA-870 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1764 UPDATE OXA-97 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1765 UPDATE OXA-56 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1143 UPDATE OXA-7 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1269 UPDATE OXA-192 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1141 UPDATE OXA-169 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2180 UPDATE glycopeptide resistance gene cluster VanL glycopeptide antibiotic; glycopeptide resistance gene cluster; antibiotic target alteration; vancomycin; model_description "UPDATED model_description with Gene Cluster Meta-Models (GCM) are used to curate spatial clusters of individual genes within operons, such as for glycopeptide resistance gene clusters. The individual genes will have their own individual detection models (e.g. PHM, PVM, POM, etc.) while the GCM checks to see if all the component genes of the cluster have a Strict or Perfect hit and are ordered correctly within an operon. GCMs are encoded using the gene order parameter. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software. " 3498 UPDATE OXA-414 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3499 UPDATE OXA-416 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3496 UPDATE OXA-412 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3497 UPDATE OXA-413 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1148 UPDATE OXA-363 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3495 UPDATE OXA-411 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3492 UPDATE OXA-407 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3493 UPDATE OXA-408 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3490 UPDATE OXA-405 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3491 UPDATE OXA-406 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1911 UPDATE AAC(6')-Iad 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1221 UPDATE OXA-231 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2711 UPDATE MexXY-OprM erythromycin; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; ofloxacin; norfloxacin; macrolide antibiotic; carbapenem; cephalosporin; ciprofloxacin; gentamicin C; amikacin; aminoglycoside antibiotic; disinfecting agents and antiseptics; penam; gentamicin; efflux pump complex or subunit conferring antibiotic resistance; cephamycin; acriflavine; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 2091 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to gentamicin C antibiotic target alteration; aminoglycoside antibiotic; gentamicin C; gentamicin; 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 653 UPDATE AAC(3)-VIIa antibiotic inactivation; AAC(3); aminoglycoside antibiotic; paromomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. " 3286 UPDATE Klebsiella pneumoniae KpnF peptide antibiotic; triclosan; rifampin; small multidrug resistance (SMR) antibiotic efflux pump; antibiotic efflux; aminoglycoside antibiotic; rifamycin antibiotic; colistin A; macrolide antibiotic; colistin B; efflux pump complex or subunit conferring antibiotic resistance; cephalosporin; cefepime; benzalkonium chloride; tetracycline antibiotic; chlorhexidine; streptomycin; ceftriaxone; disinfecting agents and antiseptics; tetracycline; erythromycin; ARO_category "DELETED 36003 UPDATED category_aro_name with small multidrug resistance (SMR) antibiotic efflux pump UPDATED category_aro_cvterm_id with 36004 UPDATED category_aro_accession with 0010003 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain. " 3654 UPDATE Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin antibiotic target alteration; Zoliflodacin; Zoliflodacin resistant gyrB; zoliflodacin-like antibiotic; ARO_category "UPDATED category_aro_name with Zoliflodacin UPDATED category_aro_cvterm_id with 42994 UPDATED category_aro_accession with 3004858 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Experimental antibiotic in phase two trial for Neisseria gonorrhoeae treatment. " 3653 UPDATE SCO-1 penam; cefalotin; antibiotic inactivation; penem; cephalosporin; cefotaxime; ceftazidime; cefepime; penicillin; ticarcillin; amoxicillin; cefuroxime; SCO beta-lactamase; piperacillin; ARO_category "DELETED 35996 " 2525 UPDATE AAC(6')-34 AAC(6'); kanamycin A; antibiotic inactivation; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 693 UPDATE OXA-22 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 690 UPDATE OXA-347 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 947 UPDATE OXA-100 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1540 UPDATE rmtC kanamycin A; aminoglycoside antibiotic; isepamicin; gentamicin; 16S rRNA methyltransferase (G1405); sisomicin; arbekacin; gentamicin B; netilmicin; antibiotic target alteration; gentamicin C; amikacin; dibekacin; G418; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 2138 UPDATE NmcA penam; carbapenem; NmcA beta-lactamase; cefazolin; cephalosporin; antibiotic inactivation; cephamycin; ampicillin; cefoxitin; ARO_category "DELETED 35981 " 4901 UPDATE OXA-575 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4900 UPDATE OXA-574 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4903 UPDATE OXA-577 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4902 UPDATE OXA-576 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4905 UPDATE OXA-579 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4904 UPDATE OXA-578 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1548 UPDATE APH(3')-Vb antibiotic inactivation; aminoglycoside antibiotic; paromomycin; APH(3'); ribostamycin; neomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 " 4906 UPDATE OXA-580 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5095 UPDATE OXA-787 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 639 UPDATE AAC(3)-IV 2'-N-ethylnetilmicin; antibiotic inactivation; AAC(3); aminoglycoside antibiotic; gentamicin; 6'-N-ethylnetilmicin; sisomicin; netilmicin; apramycin; dibekacin; tobramycin; CARD_short_name; ARO_category; model_name; ARO_name "UPDATED CARD_short_name with AAC(3)-IVa UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. DELETED 40307 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). UPDATED category_aro_name with 6'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46127 UPDATED category_aro_accession with 3007377 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED model_name with AAC(3)-IVa UPDATED ARO_name with AAC(3)-IVa " 5104 UPDATE OXA-799 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 544 UPDATE AAC(6')-Is 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 4064 UPDATE OXA-895 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1464 UPDATE aadA7 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 5105 UPDATE OXA-800 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1460 UPDATE FosB3 fosfomycin; fosfomycin thiol transferase; antibiotic inactivation; phosphonic acid antibiotic; ARO_category "UPDATED category_aro_name with fosfomycin UPDATED category_aro_cvterm_id with 35944 UPDATED category_aro_accession with 0000025 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. " 1040 UPDATE OXA-95 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4888 UPDATE OXA-559 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5064 UPDATE OXA-755 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5067 UPDATE OXA-758 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5066 UPDATE OXA-757 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5061 UPDATE OXA-752 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1312 UPDATE OXA-111 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5148 UPDATE OXA-851 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5149 UPDATE OXA-852 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4880 UPDATE OXA-551 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4881 UPDATE OXA-552 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4882 UPDATE OXA-553 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5145 UPDATE OXA-847 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5069 UPDATE OXA-760 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5068 UPDATE OXA-759 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4886 UPDATE OXA-557 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4887 UPDATE OXA-558 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 120 UPDATE aadA4 antibiotic inactivation; aminoglycoside antibiotic; ANT(3''); streptomycin; spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. " 3403 UPDATE Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide antibiotic target alteration; pyrazinamide resistant rpsA; pyrazinamide; pyrazine antibiotic; ARO_category "UPDATED category_aro_name with pyrazinamide UPDATED category_aro_cvterm_id with 39997 UPDATED category_aro_accession with 3003413 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Pyrazinamide is an antimycobacterial. It is highly specific and active only against Mycobacterium tuberculosis. This compound is a prodrug and needs to be activated inside the cell. It interferes with the bacterium's ability to synthesize new fatty acids, causing cell death. " 3405 UPDATE OXA-402 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 218 UPDATE npmA aminoglycoside antibiotic; gentamicin; 16S rRNA methyltransferase (A1408); neomycin; antibiotic target alteration; amikacin; ribostamycin; gentamicin A; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 3407 UPDATE OXA-103 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3406 UPDATE OXA-140 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3409 UPDATE OXA-123 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3408 UPDATE OXA-122 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4875 UPDATE OXA-546 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4874 UPDATE OXA-545 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4877 UPDATE OXA-548 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4876 UPDATE OXA-547 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4871 UPDATE OXA-537 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4870 UPDATE OXA-536 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4873 UPDATE OXA-542 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4872 UPDATE OXA-538 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1825 UPDATE CTX-M-27 penam; carbapenem; cephalosporin; cefazolin; ceftazidime; cefalotin; ampicillin; antibiotic inactivation; cefixime; CTX-M beta-lactamase; ertapenem; ARO_category "DELETED 40951 " 1821 UPDATE AAC(6')-Ir 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 4878 UPDATE OXA-549 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 414 UPDATE OXA-377 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3445 UPDATE OXA-280 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 416 UPDATE OXA-204 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3415 UPDATE OXA-151 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4978 UPDATE OXA-658 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4979 UPDATE OXA-659 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 412 UPDATE OXA-117 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 413 UPDATE OXA-144 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4974 UPDATE OXA-654 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4975 UPDATE OXA-655 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4976 UPDATE OXA-656 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4977 UPDATE OXA-657 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4970 UPDATE OXA-645 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4971 UPDATE OXA-650 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1382 UPDATE rmtG gentamicin; 16S rRNA methyltransferase (G1405); arbekacin; antibiotic target alteration; amikacin; aminoglycoside antibiotic; gentamicin A; tobramycin; ARO_category "UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 4973 UPDATE OXA-652 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3827 UPDATE OXA-898 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3826 UPDATE OXA-899 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 319 UPDATE OXA-366 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 318 UPDATE OXA-358 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1059 UPDATE APH(9)-Ib antibiotic inactivation; aminoglycoside antibiotic; APH(9); spectinomycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of spectinomycin, by the ATP-dependent phosphorylation of the 9-hydroxyl group of the compound. " 5002 UPDATE OXA-690 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 313 UPDATE OXA-143 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3441 UPDATE OXA-275 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3944 UPDATE OXA-544 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1923 UPDATE APH(3'')-Ia antibiotic inactivation; APH(3''); streptomycin; aminoglycoside antibiotic; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 3''-hydroxyl group of the compound. DELETED 40307 " 867 UPDATE OXA-175 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1928 UPDATE OXA-50 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; ampicillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 475 UPDATE OXA-106 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3474 UPDATE OXA-340 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3475 UPDATE OXA-341 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3476 UPDATE OXA-342 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 497 UPDATE OXA-79 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3470 UPDATE OXA-308 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3471 UPDATE OXA-336 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3472 UPDATE OXA-337 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3473 UPDATE OXA-339 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5090 UPDATE OXA-782 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5091 UPDATE OXA-783 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5092 UPDATE OXA-784 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5093 UPDATE OXA-785 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3478 UPDATE OXA-344 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3479 UPDATE OXA-345 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5096 UPDATE OXA-788 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5097 UPDATE OXA-789 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1365 UPDATE AAC(6')-I30 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 40942 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 5689 UPDATE VHH-1 antibiotic inactivation; penam; carbapenem; cephalosporin; VHH beta-lactamase; ampicillin; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. " 5074 UPDATE OXA-765 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3841 UPDATE AAC(6')-Ib-cr4 antibiotic inactivation; AAC(6')-Ib-cr; AAC(6'); kanamycin A; ciprofloxacin; fluoroquinolone antibiotic; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_name with AAC(6') UPDATED category_aro_cvterm_id with 36484 UPDATED category_aro_accession with 3000345 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. " 3419 UPDATE OXA-155 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 441 UPDATE OXA-54 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 360 UPDATE AAC(6')-Iy 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 361 UPDATE OXA-278 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 440 UPDATE MexA sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; penam; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; nalidixic acid; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 2019 UPDATE OXA-213 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 2023 UPDATE OXA-132 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 902 UPDATE OXA-92 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3319 UPDATE AAC(6')-Ian 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. DELETED 35966 UPDATED category_aro_name with 2'-N-ethylnetilmicin UPDATED category_aro_cvterm_id with 46128 UPDATED category_aro_accession with 3007378 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. UPDATED category_aro_name with 5-episisomicin UPDATED category_aro_cvterm_id with 46129 UPDATED category_aro_accession with 3007379 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. UPDATED category_aro_name with sisomicin UPDATED category_aro_cvterm_id with 35953 UPDATED category_aro_accession with 0000035 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with dibekacin UPDATED category_aro_cvterm_id with 35926 UPDATED category_aro_accession with 0000007 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with netilmicin UPDATED category_aro_cvterm_id with 35956 UPDATED category_aro_accession with 0000038 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. " 4850 UPDATE OXA-515 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 384 UPDATE APH(2'')-IVa antibiotic inactivation; gentamicin; kanamycin A; APH(2''); amikacin; aminoglycoside antibiotic; gentamicin A; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 35953 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 385 UPDATE OXA-46 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 5133 UPDATE OXA-831 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3799 UPDATE LptD antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; aminocoumarin antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; rifamycin antibiotic; ARO_description; ARO_category "UPDATED ARO_description with LptD is involved in LPS transport in a ABC Transporter efflux system. It confers resistance to rifamycin, aminocoumarin, and peptide antibiotics. DELETED 35939 " 444 UPDATE AAC(6')-Ib-Suzhou antibiotic inactivation; AAC(6'); kanamycin A; amikacin; aminoglycoside antibiotic; tobramycin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with kanamycin A UPDATED category_aro_cvterm_id with 35966 UPDATED category_aro_accession with 0000049 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. " 1925 UPDATE MexB sulfonamide antibiotic; penem; panipenem; tetracycline antibiotic; meropenem; antibiotic efflux; resistance-nodulation-cell division (RND) antibiotic efflux pump; aztreonam; trimethoprim; aminocoumarin antibiotic; cephalosporin; macrolide antibiotic; carbapenem; ceftazidime; ciprofloxacin; cephamycin; ceftriaxone; colistin B; colistin A; peptide antibiotic; diaminopyrimidine antibiotic; ticarcillin; ampicillin; penam; sulfamethoxazole; novobiocin; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; trimethoprim-sulfamethoxazole; tetracycline; monobactam; fluoroquinolone antibiotic; erythromycin; nalidixic acid; azithromycin; chloramphenicol; ARO_category "DELETED 35996 " 4056 UPDATE OXA-570 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4055 UPDATE OXA-926 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4054 UPDATE OXA-835 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4053 UPDATE OXA-541 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4052 UPDATE OXA-737 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1728 UPDATE OXA-42 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4050 UPDATE OXA-543 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 1079 UPDATE OXA-161 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4057 UPDATE OXA-573 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4059 UPDATE OXA-672 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 4058 UPDATE OXA-571 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 924 UPDATE AAC(6')-33 AAC(6'); antibiotic inactivation; amikacin; aminoglycoside antibiotic; tobramycin; ARO_description; CARD_short_name; ARO_category; model_name; ARO_name "UPDATED ARO_description with AAC(6')-I33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. UPDATED CARD_short_name with AAC(6')-I33 UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. UPDATED category_aro_name with amikacin UPDATED category_aro_cvterm_id with 35932 UPDATED category_aro_accession with 0000013 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED category_aro_name with tobramycin UPDATED category_aro_cvterm_id with 35969 UPDATED category_aro_accession with 0000052 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. UPDATED model_name with AAC(6')-I33 UPDATED ARO_name with AAC(6')-I33 " 1077 UPDATE OXA-420 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3477 UPDATE OXA-343 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 3759 UPDATE APH(3')-VIb antibiotic inactivation; aminoglycoside antibiotic; isepamicin; gentamicin; paromomycin; kanamycin A; APH(3'); gentamicin B; amikacin; ribostamycin; neomycin; butirosin; ARO_category "UPDATED category_aro_description with A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. DELETED 36997 UPDATED category_aro_name with gentamicin UPDATED category_aro_cvterm_id with 46133 UPDATED category_aro_accession with 3007382 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). " 3758 UPDATE VMB-1 penam; carbapenem; imipenem; cefotaxime; VMB beta-lactamase; cephalosporin; antibiotic inactivation; ampicillin; amoxicillin; ceftriaxone; meropenem; ARO_category "UPDATED category_aro_name with penam UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_accession with 3000008 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_name with imipenem UPDATED category_aro_cvterm_id with 36309 UPDATED category_aro_accession with 3000170 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes. UPDATED category_aro_name with cefotaxime UPDATED category_aro_cvterm_id with 36989 UPDATED category_aro_accession with 3000645 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups. UPDATED category_aro_name with cephalosporin UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_accession with 0000032 UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_name with ampicillin UPDATED category_aro_cvterm_id with 36981 UPDATED category_aro_accession with 3000637 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. UPDATED category_aro_name with amoxicillin UPDATED category_aro_cvterm_id with 35981 UPDATED category_aro_accession with 0000064 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. UPDATED category_aro_name with ceftriaxone UPDATED category_aro_cvterm_id with 35979 UPDATED category_aro_accession with 0000062 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. UPDATED category_aro_name with meropenem UPDATED category_aro_cvterm_id with 35990 UPDATED category_aro_accession with 0000073 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. " 573 UPDATE OXA-136 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. UPDATED category_aro_name with oxacillin UPDATED category_aro_cvterm_id with 35973 UPDATED category_aro_accession with 0000056 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. " 572 UPDATE OXA-137 penam; antibiotic inactivation; carbapenem; cephalosporin; cefalotin; oxacillin; cloxacillin; OXA beta-lactamase; ARO_category "UPDATED category_aro_name with cloxacillin UPDATED category_aro_cvterm_id with 35930 UPDATED category_aro_accession with 0000011 UPDATED category_aro_class_name with Antibiotic UPDATED category_aro_description with Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. UPDATED category_aro_name with cefalotin UPDATED category_aro_cvterm_id with 37084 UPDATED category_aro_accession with 3000704 UPDATED category_aro_class_name with Antibiotic UPDAT