Model_id Action ARO_name ARO_category Changes To Summary 3834 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide thioamide antibiotic; antibiotic target alteration; prothionamide resistant katG; prothionamide; model_param "UPDATED 12888 with G279V,L436P UPDATED 12889 with P92S,S315T UPDATED 12886 with S315T,V581G UPDATED 12887 with S315T,G466R UPDATED 12884 with T275A,S315T UPDATED 12885 with S211G,S315T UPDATED 12882 with C20R,S315T UPDATED 12883 with S134S,T308P UPDATED 12890 with V431A,G490S " 1176 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid isoniazid; isoniazid resistant katG; antibiotic target alteration; isoniazid-like antibiotic; model_param "DELETED 10004 UPDATED 12877 with S315T,V581G UPDATED 12876 with S211G,S315T UPDATED 12875 with C20R,S315T UPDATED 12874 with M126I,R496L UPDATED 12879 with G279V,L436P UPDATED 12878 with S315T,G466R UPDATED 12880 with P92S,S315T UPDATED 12881 with V431A,G490S " 3836 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid isoniazid; isoniazid-like antibiotic; antibiotic target alteration; isoniazid resistant ethA; model_param "UPDATED 12895 with R239Q,S266R UPDATED 12894 with S266R,P454L UPDATED 12896 with Q246R,L446P UPDATED 12891 with I161V,G324R UPDATED 12893 with S266R,M373T UPDATED 12892 with Q254P,S266R " 1138 UPDATE tet(D) tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; antibiotic efflux; model_param "UPDATED param_value with 700 " 3795 UPDATE ArnT pmr phosphoethanolamine transferase; peptide antibiotic; antibiotic target alteration; colistin B; colistin A; model_param "UPDATED param_value with 400 " 3340 UPDATE aacA43 AAC(6'); kanamycin A; antibiotic inactivation; aminoglycoside antibiotic; tobramycin; ARO_description; CARD_short_name; model_name; ARO_name "UPDATED ARO_description with AAC(6')-I-43 (aacA43) is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae. UPDATED CARD_short_name with AAC(6')-I-43 UPDATED model_name with AAC(6')-I-43 UPDATED ARO_name with AAC(6')-I-43 " 2395 UPDATE apmA antibiotic inactivation; aminoglycoside antibiotic; AAC(2'); apramycin; ARO_category "DELETED 41422 UPDATED category_aro_name with AAC(2') UPDATED category_aro_cvterm_id with 36480 UPDATED category_aro_accession with 3000341 UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound. " 1737 UPDATE ANT(4')-Ia antibiotic inactivation; tobramycin; dibekacin; ANT(4'); amikacin; isepamicin; aminoglycoside antibiotic; model_sequences "UPDATED partial with 0 UPDATED sequence with GTGAATGGACCAATAATAATGACTAGAGAAGAAAGAATGAAGATTGTTCATGAAATTAAGGAACGAATATTGGATAAATATGGGGATGATGTTAAGGCTATTGGTGTTTATGGCTCTCTTGGTCGTCAGACTGATGGGCCCTATTCGGATATTGAGATGATGTGTGTCATGTCAACAGAGGAAGCAGAGTTCAGCCATGAATGGACAACCGGTGAGTGGAAGGTGGAAGTGAATTTTGATAGCGAAGAGATTCTACTAGATTATGCATCTCAGGTGGAATCAGATTGGCCGCTTACACATGGTCAATTTTTCTCTATTTTGCCGATTTATGATTCAGGTGGATACTTAGAGAAAGTGTATCAAACTGCTAAATCGGTAGAAGCCCAAAAGTTCCACGATGCGATTTGTGCCCTTATCGTAGAAGAGCTGTTTGAATATGCAGGCAAATGGCGTAATATTCGTGTGCAAGGACCGACAACATTTCTACCATCCTTGACTGTACAGGTAGCAATGGCAGGTGCCATGTTGATTGGTCTGCATCATCGCATCTGTTATACGACGAGCGCTTCGGTCTTAACTGAAGCAGTTAAGCAATCAGATCTTCCTTCAGGTTATGACCATCTGTGCCAGTTCGTAATGTCTGGTCAACTTTCCGACTCTGAGAAACTTCTGGAATCGCTAGAGAATTTCTGGAATGGGATTCAGGAGTGGACAGAACGACACGGATATATAGTGGATGTGTCAAAACGCATACCATTTTGA UPDATED fmax with 1002 UPDATED accession with K02551.1 UPDATED fmin with 240 UPDATED strand with + UPDATED NCBI_taxonomy_name with Plasmid pTB913 UPDATED NCBI_taxonomy_id with 2641 UPDATED NCBI_taxonomy_cvterm_id with 46192 UPDATED accession with AAA92254.1 UPDATED sequence with MNGPIIMTREERMKIVHEIKERILDKYGDDVKAIGVYGSLGRQTDGPYSDIEMMCVMSTEEAEFSHEWTTGEWKVEVNFDSEEILLDYASQVESDWPLTHGQFFSILPIYDSGGYLEKVYQTAKSVEAQKFHDAICALIVEELFEYAGKWRNIRVQGPTTFLPSLTVQVAMAGAMLIGLHHRICYTTSASVLTEAVKQSDLPSGYDHLCQFVMSGQLSDSEKLLESLENFWNGIQEWTERHGYIVDVSKRIPF " 2037 UPDATE tet(T) chlortetracycline; demeclocycline; oxytetracycline; tetracycline antibiotic; tetracycline; antibiotic target protection; minocycline; tetracycline-resistant ribosomal protection protein; doxycycline; model_param "UPDATED param_value with 1200 " 5752 UPDATE Helicobacter pylori gyrA conferring resistance to fluoroquinolones levofloxacin; antibiotic target alteration; fluoroquinolone antibiotic; fluoroquinolone resistant gyrA; model_param "DELETED 12361 UPDATED 12899 with D91N,V77A UPDATED 12898 with N87K,H57Y UPDATED 12907 with S63P,R130K UPDATED 12906 with D91N,R130K UPDATED 12905 with N87K,D91N,V172I UPDATED 12904 with S63P,N87K,P188S UPDATED 12903 with S63P,D91N UPDATED 12902 with N87A,A88N,V65I UPDATED 12901 with D91Y,A97V UPDATED 12900 with D91N,A97V " 2383 UPDATE ANT(4')-Ib antibiotic inactivation; tobramycin; dibekacin; ANT(4'); amikacin; isepamicin; aminoglycoside antibiotic; model_sequences "UPDATED partial with 0 UPDATED sequence with ATGAATATGAATGGACCTGCATCAATGGCGCAAAAAGAAAGACTTCAAACTTGCCAAGAAATTGCCAAGAGATTACACGAGGTTTATGGCAACGACGTTCTCGCCATTGGCGTCTACGGTTCTGTGTCCAGAGGCACAGATGGCCCTTTCTCAGATATTGAGATGTTTTGCGTACTCCGTGACTCGGCTGAAACGGTAGATAAAAGTTATGAATGGTCAGCTGGACCGTGGAAAGCGGAAGTTAACGTTTGCAGTGCGAGTATACTGTTAAAAGACGCTGCAACCGTTGAAGACCGATGGCCGCTGACACATGGGCCTTACTTCTCTCCGCTTCGTCTCTATGATCCTGAAGGCTTCTTTCAACGCTTGCGGCTCGCAGCGGAATCGCCGACAAAAGAAGATTTCCGCCAAGCTATTCATGAAATTCTTGTAGGGGAAATGTATGAATATGTTGGCAAGCTTCGAAATGTAAATCGAAATGGCCCTTCTACCTACTTGCCATCCTTGGCATTGCGCTTTGCCCACTATGGCGCAATGTTGATCGGCCTCCACAATCAGACACTCTTTTCTACGGGCGCTATGGTTTTGCCTGAAGCGCTGAAACTGCCGCATCGGCCAAAAGGGTTCGACCATGTTGCTGAGTTAGCGATGTCTGGAGACTTAGCACAACCAGCGAAGATCGTGTCAGCGTGCGAAGATTTCTGGAAAGGCCTAGTCGCGTGGGCAGCGGAGCATGATTACGTCATTCACTCAAAACGAATCCCGTTTTGA UPDATED fmax with 985 UPDATED accession with EF540343.1 UPDATED fmin with 214 UPDATED strand with + UPDATED NCBI_taxonomy_name with Alkalihalobacillus clausii UPDATED NCBI_taxonomy_id with 79880 UPDATED NCBI_taxonomy_cvterm_id with 36882 UPDATED accession with AAO83986.1 UPDATED sequence with MNMNGPASMAQKERLQTCQEIAKRLHEVYGNDVLAIGVYGSVSRGTDGPFSDIEMFCVLRDSAETVDKSYEWSAGPWKAEVNVCSASILLKDAATVEDRWPLTHGPYFSPLRLYDPEGFFQRLRLAAESPTKEDFRQAIHEILVGEMYEYVGKLRNVNRNGPSTYLPSLALRFAHYGAMLIGLHNQTLFSTGAMVLPEALKLPHRPKGFDHVAELAMSGDLAQPAKIVSACEDFWKGLVAWAAEHDYVIHSKRIPF " 5750 UPDATE Helicobacter pylori rpoB mutation conferring resistance to rifampicin rifampin; levofloxacin; rifamycin-resistant beta-subunit of RNA polymerase (rpoB); antibiotic target replacement; antibiotic target alteration; fluoroquinolone antibiotic; rifamycin antibiotic; model_param "UPDATED 12897 with V148I,V149F " 1321 UPDATE mecA penam; methicillin resistant PBP2; methicillin; antibiotic target replacement; ARO_description "UPDATED ARO_description with A foreign PBP2a acquired by lateral gene transfer that is able to perform peptidoglycan synthesis in the presence of beta-lactams. " 3837 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide thioamide antibiotic; antibiotic target alteration; prothionamide; prothionamide resistant ethA; model_param "UPDATED 12909 with R239Q,S266R UPDATED 12908 with S266R,P454L UPDATED 12910 with Q246R,L446P UPDATED 12911 with I161V,G324R UPDATED 12912 with S266R,M373T UPDATED 12913 with Q254P,S266R " 1005 UPDATE Escherichia coli soxR with mutation conferring antibiotic resistance antibiotic target alteration; tetracycline antibiotic; antibiotic efflux; ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; norfloxacin; nalidixic acid; cephalosporin; cefalotin; ciprofloxacin; disinfecting agents and antiseptics; protein(s) and two-component regulatory system modulating antibiotic efflux; rifampin; ampicillin; penam; triclosan; efflux pump complex or subunit conferring antibiotic resistance; tigecycline; glycylcycline; fluoroquinolone antibiotic; chloramphenicol; phenicol antibiotic; tetracycline; rifamycin antibiotic; model_param "UPDATED 12870 with T38S,G74R " 3338 UPDATE AAC(6')-Iag 2'-N-ethylnetilmicin; 5-episisomicin; AAC(6'); aminoglycoside antibiotic; sisomicin; antibiotic inactivation; netilmicin; amikacin; dibekacin; tobramycin; ARO_description; CARD_short_name; model_name; ARO_name "UPDATED ARO_description with AAC(6')-I-48 (AAC(6')-Iag) is an aminoglycoside acetyltransferase encoded by integrons in Pseudomonas aeruginosa. UPDATED CARD_short_name with AAC(6')-I-48 UPDATED model_name with AAC(6')-I-48 UPDATED ARO_name with AAC(6')-I-48 " 2372 UPDATE Escherichia coli GlpT with mutation conferring resistance to fosfomycin fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; antibiotic-resistant GlpT; model_param "UPDATED 12873 with E448K,G302D UPDATED 12872 with E448K,Q444E,E443Q,L297F UPDATED 12871 with E448K,G33R " 3879 DELETE APH(3')-XVa kanamycin A; APH(3'); amikacin; aminoglycoside antibiotic; antibiotic inactivation; N/A N/A 5946 ADD TEM-245 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 5947 ADD dfrL iclaprim; trimethoprim; diaminopyrimidine antibiotic; antibiotic target replacement; tetracycline antibiotic; streptomycin; aminoglycoside antibiotic; trimethoprim resistant dihydrofolate reductase dfr; tetracycline; tobramycin; N/A N/A 5944 ADD TEM-244 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 5945 ADD KPC-99 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; monobactam; KPC beta-lactamase; N/A N/A 5942 ADD KPC-98 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; monobactam; KPC beta-lactamase; N/A N/A 5943 ADD TEM-247 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 5940 ADD TEM-246 penam; antibiotic inactivation; penem; cephalosporin; monobactam; ampicillin; TEM beta-lactamase; N/A N/A 5941 ADD KPC-97 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; monobactam; KPC beta-lactamase; N/A N/A 5948 ADD EstT antibiotic inactivation; macrolide esterase; macrolide antibiotic; tigecycline; glycylcycline; tetracycline antibiotic; N/A N/A 5949 ADD IMP-91 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A 5951 ADD IMP-92 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A 5950 ADD IMP-96 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A 5953 ADD IMP-94 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A 5952 ADD IMP-93 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A 5955 ADD IND-17 carbapenem; antibiotic inactivation; IND beta-lactamase; N/A N/A 5954 ADD IMP-95 penam; antibiotic inactivation; penem; carbapenem; cephalosporin; IMP beta-lactamase; cephamycin; N/A N/A 5956 ADD Mycobacterium avium gyrA with mutation conferring resistance to Fluoroquinolone fluoroquinolone resistant gyrA; levofloxacin; ciprofloxacin; antibiotic target alteration; fluoroquinolone antibiotic; moxifloxacin; N/A N/A 5937 ADD KPC-100 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; monobactam; KPC beta-lactamase; N/A N/A 5936 ADD NDM-45 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5935 ADD NDM-44 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5934 ADD SSA penam; antibiotic inactivation; cephalosporin; SSA beta-lactamase; ceftazidime; cephamycin; ampicillin; amoxicillin; cefoxitin; N/A N/A 5933 ADD WUS-1 penam; WUS beta-lactamase; imipenem; carbapenem; antibiotic inactivation; carbenicillin; ampicillin; N/A N/A 5932 ADD LAQ-1 LAQ beta lactamase; penam; cephalosporin; cefazolin; benzylpenicillin; cefepime; cephamycin; ampicillin; antibiotic inactivation; cefoxitin; N/A N/A 5931 ADD EBR-5 penam; antibiotic inactivation; EBR beta-lactamase; cephalosporin; carbapenem; ampicillin; ceftazidime; cefalotin; cefuroxime; piperacillin; ceftiofur; N/A N/A 5930 ADD KPC-96 penam; antibiotic inactivation; cephalosporin; carbapenem; ceftazidime; monobactam; KPC beta-lactamase; N/A N/A 5939 ADD NDM-47 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A 5938 ADD NDM-46 antibiotic inactivation; penam; carbapenem; cephalosporin; cephamycin; NDM beta-lactamase; N/A N/A